EP2277625A1 - Retaining device for blood, body fluids, tissue samples or tissue cultures - Google Patents

Abstract

The method for the assembly of a cap (20) of a sealing device (9) with the open end (6) of a receptacle (5) to form a holding unit for body fluids or tissue cultures entails exerting a pressure force (F) orientated in the direction of the longitudinal axis (14) on at least one of the components (5,20) being assembled to produce a relative movement between them. The pressure force may be exerted on the cap, in which case during the application of the pressure force the cap is held stationary in relation to the receptacle and the receptacle is set in a relative rotational or pivoting movement. Independent claims are also included for the following: (A) a cap to form a sealing device on the open end of a receptacle; (B) a receptacle for the forming with the sealing device of a sealable holding unit for body fluids, tissue or tissue cultures; and (C) a holding unit with a sealing cap and receptacle.

Description

The invention relates to a receiving device comprising a closure device, a receptacle and a threaded arrangement arranged between them, as described in claim 1.

Various recording devices, which describe from a receptacle and a coupling device can be coupled with it, are from the EP 867 678 B1 . EP 1 174 084 B1 . EP 1 174 085 B1 as well as the US 6,017,317 A1 known. In this case, a coupling device in the form of a threaded arrangement is described between the closure device, in particular the cap, and the end of the receptacle to be closed, wherein the threaded arrangement in the region of the receptacle distributed over the circumference arranged thread segments, which are each arranged spaced apart in the circumferential direction. In the region of the inside of the cap, the sealing device composed of a plurality of layers is arranged, which comprises a resealable layer, a connecting layer arranged between the latter and a gas barrier element, and a further connecting layer between the gas barrier element and the receiving container. In addition, the resealable element is glued in the cap by means of a hot melt adhesive. In this case, the connection or holding force of the further connection position between the gas barrier element and the receptacle is less than the connection force of the arranged between the resealable element and the cap hot melt adhesive. For guiding and pre-positioning of the cap with respect to the threads on the receptacle guide projections are arranged within the cap, which are seen in the circumferential direction shorter than the gap between the individual threads. The joining process of the cap with the receptacle takes place by means of a rotary or pivoting movement, which is applied to the cap.

Other closure devices of the same applicant are, for example, from EP 0 915 737 B1 have become known in which the conical sealing element used in the bottom region of the receptacle and held biased by means of engaging in the outer periphery of the receptacle cap so as to achieve sufficient tightness. The coupling takes place via a pure snap action between the cap-like closure element and the receptacle.

Another closure device of the same applicant is from the EP 0 445 707 B1 respectively. US 5,294,011 A become known, in which between the cap and the sealing element, a coupling device is arranged, which is formed in the region of the cap by over the inner surface in the direction of the longitudinal axis projecting projections and the sealing plug superior approach. In addition, an additional retaining ring is provided between the flange-shaped approach of the sealing plug and the remote from the receptacle arranged extension of the cap. For placing or screwing the cap on the receptacle on the inside of the cap guide webs or threads are arranged, which cooperate with guide projections on the receptacle. In this case, the placement of the cap by means of a Aufschraubvorganges, caused by a relative rotational movement between the cap and the receptacle, or simply pushing the cap over the guide projections on the receptacle done.

Finally, other closure devices of the same applicant from the EP 0 419 490 B1 . US 5,275,299 A . US 5,522,518 A such as US 5,495,958 A known. From these documents, on the one hand a coupling device between the cap and the receptacle and a further coupling device between the arranged in the cap sealing device and this is described. The coupling device between the cap and the receptacle is again formed here by guide projections in the region of the receptacle and thus engageable guide webs, such as threads, on the cap inside. In this case, the screwing-on movement takes place until the cap is applied far enough beyond the open front side of the receptacle, so that the guide extensions of the receptacle are moved in the free space between the end of the guide web or thread turn and the end wall of the cap. As a result, a free rotation of the cap relative to the receptacle is possible without engagement of the coupling device is present. Again, the placement of the cap by a Aufschraubvorgang or a sliding over the cap with the guide web arranged thereon could be done on the or the guide extensions on the receptacle again. This is possible due to the elasticity of the cap.

From the EP 0 753 741 A1 is a receiving device with a receptacle known has, which has two spaced apart in a longitudinal axis ends, at least one of which is formed with an opening. The inner dimension of the receptacle in the region of the first open end in the plane aligned perpendicular to the longitudinal axis is greater than the inner dimension in the region of the further end in the plane aligned parallel thereto in the same spatial direction. Furthermore, an annular component is used in the open end, which covers the open end side of the receptacle with a collar and a cylindrical wall portion projects into the interior of the receptacle at least partially. The annular component has, following the cylindrical wall part, a shoulder and, connected thereto, a cross-sectional widening on which the elastic sealing element of the separating device is supported in the starting position. In the center, the separator has a recess which is closed with a thin cover plate in the region of the upper end of the receptacle. The joining of the individual components, in particular the onset of the separating device, takes place in a vacuum chamber, since after insertion of the separating device without damaging it, access to the interior is no longer possible. In addition, a film is still glued to the collar-shaped projection of the annular member and attached a cap. The filling of the interior is carried out by means of a puncture of the thin cover plate of the separator, the thin film and possibly the cap. Through this filling process, the vacuum is reduced in the interior, which also air is sucked into the interior. Subsequently, there is the centrifuging process, in which the separating device emerges from the annular member in the direction of the closed end and further comes with its sealing element on the inner surface of the receptacle to the plant. The rate of descent in the mixture or the already separated components is determined by the contact pressure of the elastic sealing element on the inner surface. By choosing the density of the entire separation device with respect to the components of the mixture to be separated, they float at the interface between the two different density media. A passage of the lighter medium during the centrifuging process is possible between the inner surface of the receptacle and the elastic sealing element.

Another receiving device with a separator is from the EP 1 005 910 A2 become known, which has a cylindrical receptacle with almost having a constant inner diameter. At the open end of the receptacle, a pierceable closure device is arranged, on which, even in the starting position, the separation device is arranged almost fitting. This separator is formed of a flexible recoverable material, wherein on the outer periphery of the separator, a sealing device is provided for sealing with the inner surface of the receptacle. In addition, a deformable element is still used in the interior, which is pressed during the application of the centrifugal force by the pressure exerted by the medium to the inner wall of the outer container and between the separator and the inserted deformed insert a flow channel is formed, which after removal of the Centrifugal force again assumes a sealing position with the arranged on the separator sealing elements, whereby the separated media remain separated from each other.

It is already a receiving device for a mixture of at least two media, according to DE 195 13 453 A1 known, which has a eprouvettenartigen receptacle which is closed in an open Stirnendbereich with a closure device and in which a separation device for separating the different media of the mixture is used after separation. In order to prevent the subsequently coming into contact with a medium face of the separator is contaminated when filling the mixture into the interior of the container, the separator is provided in the central region with a through hole through which the mixture in the remaining interior of the receptacle can be introduced. During the subsequent separation process by centrifugation in a conventional manner with a radial centrifugal force (rcf) of 1,000 g to 5,000 g - g being gravity and 1 g a value of 9,81 m / s ² - this becomes a medium separated from the mixture transferred by the breakthrough in the separating device in the area located between the sealing device and the separating device and decreases as a result in the direction of the closed end of the receptacle from. In order to prevent that after separation by the breakthrough, the other medium located between the closed end and the separating device can mix again with the medium separated therefrom, in one of the usual remaining amount of the other medium corresponding height is in the direction of the closed End cone-shaped widening end stop provided, with which the separator on the end stop, which penetrates through the aperture, runs up. As soon as the outer diameter of the end stop corresponds to the inner diameter of the opening, the separating device remains in this position and thereby the opening is closed with the stop and there can be no exchange or re-mixing of the two media. A disadvantage of this embodiment, that a tube must be made with an internal stop and no safe function of the medium separation, due to the arranged in the separator breakthrough, can be ensured. Furthermore, a subsequent insertion of the separator into the interior of the receptacle is difficult to implement.

Other recording devices for centrifuging mixtures to be separated from at least two different media, in which the receptacle is closed in both Stirnendbereichen with a closure device are known from WO 96/05770 A1 known. Inside a separating device formed by a sealing disc is arranged, which is formed by a gel. During the centrifuging operation, this gel piston migrates due to its specific gravity, which is higher than the specific gravity of the medium of lower specific gravity and lower than the specific gravity of the higher specific gravity medium, due to the centrifugal forces acting on it between the two different, separate media. In this position positioned so that a separation of the one medium from the other medium of the mixture take place. The disadvantage here is that the storage time, due to the separation device made of gel, in many cases is not sufficient for the normal duration of use.

Further receiving devices having therein separating devices, which are formed with a variety of valve assemblies and filter elements, are from the EP 0 311 011 A2 , of the US Pat. No. 3,897,343 , of the US 3,897,340 A . US 4,202,769 A as well as the US 3,897 . 337 A known.

Other recording devices with therein separation devices are from the EP 1 106 250 A2 . EP 1 106 251 A2 . EP 1 106 252 A2 . EP 1 106 253 A2 and the EP 1 107 002 A2 have become known, the separation devices are formed in a variety of embodiments and based on the principle of deformability of a component of the separation device during the centrifugation and the density of votes between the media to be separated.

The present invention has for its object to provide a recording device formed from a closure device and a receptacle, in which the operator safety is increased for the person handling.

The object of the invention is achieved by a receiving device according to the features indicated in claim 1. The resulting from the combination of features of the characterizing part of this claim advantages are that thereby still engaging threads the withdrawal movement of the cap can be supported together with the sealing device from the receptacle and at the same time already a pressure equalization between the interior of the receptacle and the outer atmospheric environment take place without aerosols being transferred to the person handling it. These are derived between the outer surface of the receptacle and the inner surface of the cap skirt. As a result of the threads, which are always in engagement with one another, mutual guidance is ensured over the entire rotary or pivoting movement as far as reaching the completely screwed-on position and during release.

Another advantage is that only by applying a directed in the direction of the longitudinal axis of the receptacle or the cap pressure force (F) in cooperation of arranged between these components of the assembly thread assembly, this axially acting pressure force (F) a relative pivoting or rotational movement between generates these components and so the screwing up or screwing is performed. As a result, otherwise necessary assembly machines, which perform the previously required for this rotation or pivoting movements can be saved. This method according to the invention leads to a reduction in costs in the field of automatic assembly machines, since only a simple longitudinal movement with corresponding application of force is to be carried out here. Furthermore, a cost reduction by the smaller footprint and by the possible with this method shorter cycle times can be achieved. In addition, however, the cost of the resulting maintenance or repairs are reduced by the simplified joining process.

Furthermore, a procedure according to the features indicated in claims 2 to 4 is advantageous, because thereby the handling of the joining or mounting operation of the receiving device better and easier to perform. By the predetermined retention of the cap or the receptacle can optionally be brought to the receptacle and / or the cap in the relative pivoting or rotational movement by the application of the predeterminable compressive force (F). In addition, but here also the cap loosely placed on the receptacle, then the one or more receptacles fixedly held and by subsequent application of the compressive force (F) the cap are moved in a rotational movement relative to the receptacle, whereby the joining process performed and at corresponding Selection until fully unscrewed. As a result, a multiple arrangement of recording devices to be screwed is possible, whereby in addition a simple and quick installation can be carried out at low machine cost.

A further advantageous procedure is described in claim 5, whereby in the interaction of the coupling device between the cap and the receptacle in the form of the threaded arrangement a definite pre-definable Aufschraubbewegung is performed. By choosing the amount of pressure and the Aufsetzgeschwindigkeit a definite definable end position between the components to be joined can be achieved.

Another, advantageous procedure is described in claim 6, as a tight closure device for the receptacle can be created, which can be introduced in a simple manner by a pure implementation of a linear movement in a rotary motion in the receptacle.

By the procedure according to the method step according to claim 7, a uniform conversion of the axial compressive force is achieved in a rotary motion.

A further, advantageous procedure is described in claim 8, since thereby the components to be joined together or assembled to each other always assume the same starting position and thus always a predefined end position can be achieved.

Also advantageous is a variant of the method according to claim 10 or 11, because characterized depending on the coating and selected pitch angle of the mutually engaged

Threads the required compressive force for assembly can be reduced or reduced, whereby a safe and rapid joining process is possible. Likewise, however, this can additionally influence the sealing behavior between the sealing plug and the receptacle.

Further, a procedure according to the features indicated in claims 12 to 17 is advantageous, since thereby the coating can be applied in a selective manner depending on the different friction conditions between the components to be joined and thereby depending on the application the corresponding friction values with a suitable choice of the coating can be reduced.

Finally, a procedure according to the features indicated in claim 18 is advantageous, since so in a single operation a large number of receiving devices can be completed, which in short cycle times a large number of assembled receiving devices can be achieved. Likewise, so can be found even with a small footprint for the joint joining process Auslangen.

However, this object of the invention is also achieved independently by the features of claim 19. The resulting from the features of the characterizing part of claim 19 surprising advantage is that by the choice of the pitch angle in cooperation with the applied compressive force by pure axial application of the compressive force (F) of the joining process between the components to be mounted can take place. When choosing the pitch angle on the one hand, the implementation of the pure axial compressive force in a relative rotational or pivotal movement between the cap and the receptacle and on the other hand to take into account the unique insertion movement of the sealing plug into the receptacle. Due to the exact selection can thus be carried out in a simple manner, the joining or screwing.

Due to the development according to claim 20 or 21, the pitch angle can be varied in other limits and so depending on the components to be joined, an exact fine tuning can be performed.

Due to the design according to claim 22 can simultaneously with a low material savings also the screwing or joining process can be facilitated.

Also advantageous is a further embodiment according to claim 23 or 24, characterized in that with a shorter pivoting angle a complete Aufschraub- or Aufsetzvorgang the cap on the receptacle is achieved. Likewise, the compressive force necessary for the joining or screwing operation is better distributed over the entire circumference of the cap or the receptacle and thus achieves a uniform loading of the components to be joined by the multi-threaded assembly.

A further advantageous embodiment is that a simpler and better pre-centering of the cap relative to the receptacle is made possible at the beginning of the joining process.

Due to the embodiment according to claim 26 or 27, it is possible that a sufficient pitch angle can be achieved over the height of the extending thread, which converts the force acting on the cap pressure force in a pivoting or rotational movement.

According to another embodiment variant according to claim 28 is seen over the circumference simpler production and associated demolding of the cap from the mold allows.

Due to the construction according to claim 29, it is possible to favor the pre-positioning of the cap relative to the receptacle and further facilitate the subsequent joining process also.

Also advantageous is a development according to claim 30, since, depending on the choice of the coating, the static friction and / or sliding friction between the components to be joined is easy and can be determined beforehand in particular for the joining operation.

Through the development according to claim 31, it is possible even better to coordinate the coating on preferably different, mutually engaged materials, thus further reducing the coefficient of friction and so facilitate the joining process or simplify.

Also advantageous is an embodiment according to claim 32, since so the friction-reducing components are kept in stock within the cap in stock and, for example, can only be used in the first joining operation. This allows a predefined placement within the cap anywhere.

Through the development according to claim 33 ensures that already in the entire material or the material for the formation of the cap, the lubricant or lubricant additive in a corresponding distribution at least over the entire inner surface of the cap is incorporated or incorporated, whereby the application of a additional coating can be saved.

In the embodiment according to claim 34, it is advantageous that, due to the selected low surface roughness between the cooperating sections of the thread arrangement, the friction and the pressure force (F) to be applied can additionally be reduced for the joining process.

Through the development according to claim 35 it is achieved that the sealing device can be kept clearly positioned by the coupling device in the cap, whereby a common joining operation of the cap together with the sealing device is made possible with the end of the receptacle to be closed in one operation.

It is also advantageous embodiment according to claim 36, since thereby parts of the coupling device for holding the sealing device are created within the same within the cap, so as to prevent accidental release of the cap of the sealing device for the joining operation and the subsequent handling operations in the intended use ,

Due to the construction according to claim 37, it is possible to achieve an even more effective coupling and thus tighter attachment between the sealing device and the cap. In addition, when projecting the approach of the sealing device over the outer cap coat beyond a rolling backup, for example, on a flat surface, for the entire recording device are created in their intended use.

Finally, an embodiment of the cap according to the features specified in claim 38 is advantageous, since on the one hand improves the handling of the closure device for the removal of the receptacle and on the other hand, the support of the entire receiving device is improved in the storage position on a storage surface.

Also advantageous is an embodiment according to claim 39, since thereby the approach of the sealing device also comes in the region of this facing end face of the receptacle to a sealing abutment and thereby reduces the sealing surface in the region between the inner wall of the receptacle and the sealing surface of the plug inserted into the interior can be.

However, this object of the invention is also achieved independently by the features of claim 40. The resulting from the features of the characterizing part of claim 40 surprising advantage is that as determined by the choice of the pitch angle or the associated distancing of the thread beginning towards the threaded end in the direction of the longitudinal axis clearly and predictable and so the joining process by applying an exclusive compressive force is converted into a relative rotational or pivoting movement between the components to be joined or converted.

Due to the development according to claim 41 or 42, the pitch angle can be varied in other limits and so depending on the components to be joined an exact fine tuning can be performed.

In accordance with claim 43, a portion of the thread assembly is formed for the receptacle, at the same time achieved with a low material savings associated weight saving and the Aufschraub- or joining process can be facilitated.

Due to the construction according to claim 44 or 45, a complete Aufschraub- or Aufsetzvorgang the cap can be achieved on the receptacle with a shorter pivoting angle. Likewise, the multi-start thread arrangement distributes the pressure force necessary for the joining or screwing operation over the entire circumference of the cap or receptacle, thus achieving uniform loading of the components to be joined.

Also advantageous is an embodiment according to claim 46, as a simpler and better pre-centering of the cap is made possible relative to the receptacle already at the beginning of the joining process.

According to one embodiment, as described in claims 47 to 49, a threaded arrangement is achieved in which seen over the circumference, the individual threads extend only over a portion of the circumference and a predeterminable gap remains between the threads. Due to this design, it is possible to arrange the mold parting plane of the tool to form the threads along the same and at the spaced apart locations in the region of the gap, the mold parting plane by the pitch-related displacement of the threaded ends or thread starts inclined to arrange between them. As a result, a simpler tool design and an associated easier opening movement is achieved. Due to the multiple arrangement of the cavities in a narrower space additional production and manufacturing costs for the tools can be saved.

In this case, an embodiment according to claim 50 or 51 proves to be advantageous because thereby jamming or jamming during the joining process in the region of the coupling device between the cap and the receptacle is avoided.

According to an advantageous embodiment according to claim 52, a mutual jamming between the individual threads during the placement or Aufschraubvorganges is avoided.

Of advantage, however, is also an embodiment according to claim 53, because this without a high Vorpositionieraufwand the cap on the receptacle is placed and then the joining process to the end position is easy to carry out.

According to claim 54, in connection with the introduced compressive force (F) converted relative rotational movement is additionally facilitated.

In the embodiment according to claim 55 improved guidance, in particular during the unscrewing of the cap from the receptacle is achieved.

But are also possible embodiments according to claims 56 to 59, as this facilitates the implementation of the axial force in the rotational movement when screwing and the interaction with the thread assembly in the cap is improved.

It is also possible an embodiment according to claim 60, since so when unscrewing the cap at the same time the sealing plug is completely removed from the receptacle. In addition, the handling during assembly is not adversely affected.

By the formation of claim 61, it is possible to favor the pre-positioning of the cap relative to the receptacle and further facilitate the subsequent joining process also.

Also advantageous is a development according to claim 62, since thereby, depending on the choice of the coating, the static friction and / or sliding friction between the components to be joined easily and especially for the joining process is determined beforehand safely.

In the embodiment according to claim 63, it is advantageous that thereby also the insertion of the plug of the sealing device into the interior of the receptacle can be substantially facilitated.

By the development according to claim 64, it is possible even better to coordinate the coating on preferably different, mutually engaged materials, thus further reduce the friction coefficient and thus facilitate the joining process or simplify.

The embodiment according to claim 65 allows a further reduction of the friction coefficient even before the joining process, whereby a subsequent application of a coating can optionally be saved.

But are also advantageous embodiments according to claims 66 to 71, as this already in the starting position or starting position of the separation device, a predefined retention force can be ensured for the inserted into the interior separator before the start of the centrifuging and thus during the filling. An improved position fixation of the movable relative to the receptacle separation device in the working position is achieved with advantage according to the features specified in the claims 72 to 74 features. In this case, the separating device with its end of the receptacle facing the end portion or even with the sealing device on this preferably designed as a stop surface positioning come upon reaching the predeterminable working position to the plant. This is a further movement and thus a possible unwanted mixing in any case secured prevented.

But is also advantageous development according to claim 75, since by the choice of the size of the taper or the decrease of the inner cross-sectional dimension of the receptacle of the predeterminable Verstellweg the separator up to its working position in which an all-round continuous sealing separation between the interior, which is arranged between the separating device and the closed end or the separating device and the open end of the receptacle, is easy to fix.

The object of the invention can also be achieved independently by the features of claim 76. The surprising advantage resulting from the features of the characterizing part of claim 76 is that by providing at least one flow channel between the inside of the container wall of the receiving container and the insertable separating device, a flow connection between the portion of the interior on both sides of the separator to be used, namely between the separator and the closed end of the receptacle and between the separating device and the end closable by the closing device. As a result, it is now possible to create a receiving device from the receiving container and the closure device with a separating device inserted therein, which makes it possible already during the filling during the intended use - such as the blood collection - on the one hand a flow of residual air from the arranged below the separator interior into the allow above trained interior and on the other hand to allow passage of subsets of the material to be filled into the interior through this or these flow channels. This countercurrent flow can also through the flow channel at the same time respectively. This allows a so-called rearrangement of residual amounts of air between the two sections on both sides of the separation device in a simple manner to thereby facilitate the filling process of the material to be recorded, in particular blood, additionally.

In accordance with claim 77, a minimum flow cross-section is defined which, with regard to the material to be filled, in the present case blood, has a sufficient size or a corresponding cross-section which causes the flow channel to be displaced due to the surface tension inherent in the blood or the density thereof during the process Filling process prevented.

In the embodiment according to claim 78, at least one through-flow channel is created, which allows unimpeded insertion of the separating device into the interior in its initial position, without any inadvertent closing of the same being connected thereto.

In the embodiment according to claim 79, a sufficient tightness of the entire receiving device is achieved even in the region of the sealing plug used.

It is also possible an embodiment according to claim 80, as well as in the work or separation position of the separation device a perfect seal is provided on both sides of the separator arranged subspaces of the interior.

Of advantage is also an embodiment according to claim 81, characterized as a function of the selected wall thickness of the container wall and in the recess of the receptacle has a sufficient permeability, so as to ensure the longest possible storage time before use and use for its intended use.

But there are also embodiments, as described in claims 82 to 84, possible, since here by the arrangement a plurality of recesses a larger flow volume and with a relative arrangement relative to each other also a position-independent use during the filling without a separate orientation is made possible.

However, it is also advantageous embodiments as characterized in the claims 85 to 89, as so in a flat or rounded transition from the base surface toward the inner surface of the receptacle in that of the open end facing or closer area better demoldability for the Receptacle is made possible during manufacture. Correspondingly circular or planar boundary surfaces or transition surfaces while avoiding sharp edges prevents bursting of the erythrocytes, which otherwise falsifies subsequent analysis processes or even prevented. Likewise, by appropriate training and arrangement of the boundary surfaces or transition surfaces and an attachment of blood cells and thus avoiding residues in the region of the recesses prevented.

But are also advantageous embodiments according to claims 90 and 91, as this one hand, an additional retaining device is made possible with simultaneous formation of the or the flow channels in cooperation with the separator to be inserted into the receptacle. Due to the parallel arrangement, a rectilinear passage of the residual air quantities and, on the other hand, the material to be filled in, in particular blood, is additionally created.

However, it is also possible to have an embodiment according to claim 92, since the at least partially formed surface structure causes a beading of the material to be filled on the structured surface, wherein the surface structure embedded either in the nanometer or micrometer waveform or by additionally embedded in the material of the receptacle or embedded micro- or nanoparticles is created. In order for an adhesion and associated falsification of the subsequent analysis process is largely prevented.

But are also advantageous embodiments of the receptacle, as they are characterized in the claims 93 and 94, since so in combination with the appropriate choice of the pitch angle of the joining process with the cap by applying an exclusive compressive force and converting the same into a relative rotation or Pivoting movement between the components to be joined takes place.

The object of the invention is also solved by the features of claim 95.

The resulting from the combination of features of the characterizing part of this claim advantages are that by the combination of the cap with the receptacle of the joining process and the associated assembly effort can be greatly simplified, which otherwise conventional automatic assembly machines, the relative rotational or pivotal movement between the could be saved to be joined components. Likewise, however, the cycle times are increased and thus a higher output achieved, which additionally savings can be achieved.

It is also possible an embodiment according to claim 96, since the additional coating substantially facilitates the insertion or screwing of the plug of the sealing device into the interior of the receptacle and so the pressure forces can be minimized.

It is also an education, as characterized in claim 97, of advantage, since so in a known manner with appropriate choice of negative pressure, a suction of the material to be filled into the interior, especially blood, supported during the removal process and so otherwise occurring friction losses and in more Consequence a proper filling process is made possible.

Due to the construction according to claim 98, the insertion of the sealing plug into the cap from this side can be substantially facilitated because the radially projecting approach of the sealing plug must be minimally compressed and then a secure mounting of the sealing plug in the cap can be achieved.

Also advantageous is a further embodiment according to claim 99, since on the one hand the cap is positioned relative to the receptacle and on the other hand, the approach of the sealing device can be additionally brought to the end face of the receptacle for sealing engagement.

By the formation according to claim 101, it is possible to have already spent the interior of the plug of the sealing device out of engagement with the receptacle and yet the threads for safe handling of the entire receiving device are engaged with each other.

According to another embodiment according to claim 102, the Abschraubweg and the associated axial displacement of the sealing plug in the direction of the longitudinal axis is minimized so far that at least one channel is formed and still the threads of the thread assembly are engaged.

Also advantageous is a development according to claim 103, as a sufficient investment or sealing surface between the plug used and the inner wall of the receptacle can be created.

By the formation according to claim 104, it is possible to ensure the formation of the channel to form the flow connection between the interior and the outer atmospheric environment while using the thread assembly according to the invention while maintaining the previously used sealing plugs.

Of advantage, however, is an embodiment of the receiving device, as this is characterized in claim 105, since on the one hand, a sufficient sealing surface between the sealing device and the receptacle can be maintained and on the other hand with still engaged threads already a flow connection between the interior of the receptacle and the external atmospheric environment can be created.

The embodiment according to claim 106, it is possible to achieve an even more effective coupling and associated firmer support between the sealing device and the cap. In addition, when projecting the approach of the sealing device over the outer cap coat beyond a rolling backup, for example, on a flat surface, for the entire recording device are created in their intended use.

Finally, an embodiment as characterized in claim 107, an advantage, since so between the approach of the sealing plug and the cap an additional rotation can be created, whereby a common Aufsetzbewegung the entire closure device is always achievable on the receptacle.

The invention will be explained in more detail below with reference to the embodiments illustrated in the drawings.

Fig. 1

eine erfindungsgemäß ausgebildeten Aufnahmeeinrichtung, umfassend einen Aufnahmebehälter mit vollständig aufgesetzter Verschlussvorrichtung, in Ansicht geschnitten und schematisch vereinfachter Darstellung;

Fig. 2

den Aufnahmebehälter und die Kappe mit entferntem Dichtstopfen im Bereich einer Fertigungs- bzw. Fügeanlage in voneinander getrennter Stellung, in An- sicht, teilweise geschnitten und vereinfachter, schematischer Darstellung;

Fig. 3

eine erfindungsgemäße Kappe in schaubildlich vereinfachter und geschnittener Darstellung;

Fig. 4

die Kappe nach Fig. 3 in Ansicht geschnitten;

Fig. 5

die Kappe nach den Fig. 3 und 4 in schaubildlich vereinfachter Darstellung;

Fig. 6

einen erfindungsgemäßen Aufnahmebehälter in schaubildlich vereinfachter Dar- stellung;

Fig. 7

einen Teilbereich des Aufnahmebehälters nach Fig. 6 in Ansicht und schematisch vereinfachter Darstellung;

Fig. 8

den Aufnahmebehälter nach den Fig. 6 und 7 in Draufsicht auf das zu verschlie- ßende Ende;

Fig. 9

einen Teilabschnitt des Aufnahmebehälters nach den Fig. 6 bis 8 im Bereich des Gewindeganges in Ansicht geschnitten und vergrößerter, schematisch vereinfach- ter Darstellung;

Fig. 10

den Aufnahmebehälter und die Kappe mit entferntem Dichtstopfen im Bereich

Fig. 11

einer anderen Fertigungs- bzw. Fügeanlage in noch voneinander getrennter Stel- lung, in Ansicht, teilweise geschnitten und vereinfachter, schematischer Darstel- lung; mehrere mögliche und gegebenenfalls für sich eigenständige Ausbildungen des Aufnahmebehälters mit einer zusätzlichen in den Innenraum einzusetzenden Trennvorrichtung, in Ansicht geschnitten und schematisch vereinfachter Darstel- lung;

Fig. 12

einen Teilbereich einer weiteren möglichen Ausbildung des Aufnahmebehälters, in schaubildlich vereinfachter Darstellung;

Fig. 13

den Aufnahmebehälter nach der Fig. 12 mit darin eingesetzter Trennvorrichtung, in Ansicht geschnitten und schematisch vereinfachter Darstellung;

Fig. 14

den Aufnahmebehälter nach den Fig. 12 und 13 mit einer zusätzlichen Positio- niervorrichtung für die Trennvorrichtung, in Ansicht geschnitten und schematisch vereinfachter Darstellung;

Fig. 15

einen Teilbereich des Aufnahmebehälters nach Fig. 13, jedoch ohne Trennvor- richtung, in Ansicht geschnitten und vereinfachter vergrößerter Darstellung;

Fig. 16

einen anderen Teilbereich des Aufnahmebehälters im Bereich der Ausnehmung, in Draufsicht geschnitten gemäß den Linien XVI - XVI in Fig. 14 sowie verein- fachter vergrößerter Darstellung;

Fig. 17

eine weitere erfindungsgemäße Kappe mit segmentweise ausgebildeten Gewin- degängen, in Ansicht geschnitten und vereinfachter vergrößerter Darstellung;

Fig. 18

einen anderen erfindungsgemäßen Aufnahmebehälter mit segmentweise ausge- bildeten Gewindegängen, in schaubildlich vereinfachter Darstellung;

Fig. 19

eine weitere erfindungsgemäße Kappe mit einer darin gehalterten Dichtungsvor-

Fig. 20

richtung sowie einem schürzenförmigen Fortsatz, in Ansicht geschnitten und ver- einfachter vergrößerter Darstellung; einen weiteren Teilbereich einer anderen Ausführungsform des Aufnahmebehäl- ters zur Ausbildung des Durchströmkanals, in Ansicht geschnitten und schema- tisch vereinfachter Darstellung.

Fig. 21

eine Möglichkeit zum Aufbringen einer Beschichtung auf die Dichtungsvorrich- tung, in Ansicht, teilweise geschnitten und stark schematisch vereinfachter Dar- stellung;

Fig. 22

eine andere Möglichkeit zum Aufbringen der Beschichtung auf den Aufnahme- behälter, in Ansicht geschnitten und stark schematisch vereinfachter Darstellung;

Fig. 23

einen Teilbereich einer anderen erfindungsgemäßen Aufnahmeeinrichtung mit einer Kappe in deren vollständig aufgeschraubter Position am Aufnahmebehälter, in Ansicht geschnitten und stark vereinfachter schematischer Darstellung;

Fig. 24

die Aufnahmeeinrichtung nach Fig. 23, jedoch in einer teilweise abgeschraubten Position der Kappe, mit noch in Eingriff befindlichen Gewindegängen.

Show it:

Fig. 1

an inventive receiving device, comprising a receptacle with fully attached closure device, cut in view and schematically simplified representation;

Fig. 2

the receptacle and the cap with removed sealing plug in the region of a manufacturing or joining system in a separate position, in view, partially cut and simplified, schematic representation;

Fig. 3

a cap according to the invention in diagrammatically simplified and cut representation;

Fig. 4

the cap after Fig. 3 cut in view;

Fig. 5

the cap after the 3 and 4 in a graphically simplified representation;

Fig. 6

a receptacle according to the invention in diagrammatically simplified representation;

Fig. 7

a portion of the receptacle after Fig. 6 in view and schematically simplified representation;

Fig. 8

the receptacle after the 6 and 7 in plan view of the end to be closed off;

Fig. 9

a portion of the receptacle after the Fig. 6 to 8 in the area of the thread in view cut and enlarged, schematically simplified representation;

Fig. 10

the receptacle and the cap with the sealing plug removed in the area

Fig. 11

another manufacturing or joining plant in still separate position, in view, partially cut and simplified, schematic representation; several possible and possibly independent constructions of the receptacle with an additional to be used in the interior separator, cut into view and schematically simplified representation;

Fig. 12

a portion of a further possible embodiment of the receptacle, in perspective simplified representation;

Fig. 13

the receptacle after the Fig. 12 with inserted therein separation device, cut in view and schematically simplified representation;

Fig. 14

the receptacle after the Fig. 12 and 13 with an additional positioning device for the separating device, in view cut and schematically simplified representation;

Fig. 15

a portion of the receptacle after Fig. 13 , but without separator, cut in elevation and simplified enlarged view;

Fig. 16

another portion of the receptacle in the region of the recess, cut in plan view according to the lines XVI - XVI in Fig. 14 as well as simplified enlarged representation;

Fig. 17

a further cap according to the invention with segmented thread turns, cut in view and simplified enlarged view;

Fig. 18

another receptacle according to the invention with segmentally formed threads, in a graphically simplified representation;

Fig. 19

a further cap according to the invention with a sealing projection held therein;

Fig. 20

direction and a skirt-shaped extension, cut in elevation and simplified enlarged view; a further portion of another embodiment of the receiving container for forming the flow channel, cut in view and schematically simplified representation.

Fig. 21

a possibility for applying a coating to the sealing device, in view, partially cut and very schematically simplified representation;

Fig. 22

another possibility for applying the coating on the receiving container, cut in view and highly simplified schematic representation;

Fig. 23

a portion of another receiving device according to the invention with a cap in its fully screwed position on the receptacle, cut in view and highly simplified schematic representation;

Fig. 24

the receiving device after Fig. 23 but in a partially unscrewed position of the cap, with threads still engaged.

By way of introduction, it should be noted that in the differently described embodiments, the same parts are provided with the same reference numerals or the same component names, wherein the disclosures contained in the entire description can be mutatis mutandis to the same parts with the same reference numerals or component names. Also, the location information chosen in the description, such as top, bottom, side, etc. related to the immediately described and illustrated figure and are to be transferred to the new situation mutatis mutandis when a change in position. Furthermore, individual features or combinations of features from the various exemplary embodiments shown and described can also represent separate, inventive or inventive solutions or can also be combined with one another as desired.

In the Fig. 1 to 9 is a receiving device 1 eg for a mixture 2 of at least two to each other different components or media 3, 4, such as body fluids, tissue parts or tissue cultures shown.

The receiving device 1 consists of an approximately cylindrical receptacle 5 with two mutually distanced ends 6, 7, wherein in this embodiment, the end 6 is formed open and the end 7 is formed by an end wall 8 closed. The open end 6 here is closed with a closure device 9 shown in a simplified manner, if necessary, and can, for example, according to the EP 0 445 707 B1 , of the EP 0 419 490 B1 , of the US 5,275,299 A , of the US 5,495,958 A as well as the US 5,522,518 A to avoid repetition, reference is made to the disclosure for the formation of the cap, the sealing device, the housing, the coupling device between the cap and the sealing device and the cap and the receptacle 5 and the arrangement of the retaining ring and is incorporated in the subject application. In a space enclosed by the receptacle 5 interior 10 may additionally be used a separator, which is not shown here. The procedural procedure for the assembly or assembly between the closure device 9 and the receptacle 5 will be described in more detail below. This receptacle 5 with the closure device 9 may for example be designed or used as an evacuated blood sampling tube in various embodiments.

The receptacle 5, for example, bottle, vial, piston-shaped or the like. Formed and made of a variety of materials, such as plastic or glass, be formed. Is selected for the receptacle 5 as the material plastic, this may be liquid-tight, in particular waterproof and optionally gas-tight and for example of polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), polystyrene (PS), high-density polyethylene (PE -HD), acrylonitrile-butadiene-styrene copolymers (ABS) or the like or a combination thereof. Furthermore, the receptacle 5 has a container wall 11 with a wall thickness 12, wherein the container wall 11, starting from the one end 6 with an inner dimension 13 in a direction perpendicular to a running between the two ends 6, 7 longitudinal axis 14 level 15 out to a further, arranged in the region of the end 7 and extending parallel to the first plane 16 extending further level 16 with a smaller dimension 17 extends. The container wall 11 of the receptacle 5 has an inner surface 18 facing the inner space 10 and an outer surface 18 facing away from it, which thus defines an outer circumference for the receptacle 5. Due to the inner surface of the container wall 11 with the inner clear dimension 13, 17 is thus an internal cross section, which may have a variety of cross-sectional shapes, such as circular, elliptical, oval, polygonal, etc., set. The shape of the outer cross section may also be circular, elliptical, oval, polygonal, etc., but it is also possible to make the shape of the outer cross section different from the shape of the inner cross section.

It is advantageous if the inner dimension 13 of the receptacle 5, starting from one end 6 to the distant from this further end 7 is continuously minimally reducing to the inner dimension 17 is formed, for example, the receptacle 5, if this plastic material in a Injection molding process is made to be able to easily remove from the injection molding tool. Further, by this tapered taper between the two planes 15, 16, the extent of the decrease of the inner dimension from the larger dimension 13 to the smaller dimension 17 is predetermined. The taper or taper angle is, based on the inner opposite surfaces of the receptacle 5, between 0.1 ° and 3.0 °, preferably between 0.6 ° and 1.0 °. It should be noted at this point that the dimensions described are based on the distance between the opposing inner or outer surfaces 18 of the components, the diameter, the circumference along an envelope or a Hüll line and the cross-section or the cross-sectional area respectively in one of the aligned perpendicular to the longitudinal axis 14 planes and always the same spatial direction for determining the dimensions 13, 17 can relate.

As can further be seen from this illustration, the end 6 has an open front side 19, which can be closed by the closure device 9, which can be opened as required. For this purpose, the closure device 9 consists of a cap 20 enclosing the open end 19 and a sealing device 21 held therein, such as a sealing plug 22 made of a pierceable, highly elastic and self-sealing material, such as pharmaceutical rubber, silicone rubber or bromobutyl rubber. This cap 20 is usually arranged concentrically to the longitudinal axis 14 and formed by a circular ring Cap jacket 23 formed. Between the cap 20 and the sealing device 21 are means for coupling, such as coupling parts 24 to 27 of a coupling device 28, consisting in the cap 20 from at least over the inner circumference partially arranged projections 29, 30, optionally a retaining ring 31, and in the sealing device 21st from an at least partially projecting over its outer periphery approach 32nd

The sealing device 21 is formed in the present embodiment by the sealing plug 22 and has a circumferential and approximately concentric with the longitudinal axis 15 arranged cylindrical sealing surface 33, which comes in its sealing position in the section of the end 6 on the inner surface of the receptacle 5 to the plant. As a result, the inner surface of the receptacle 5 should be formed in its surface quality as a sealing surface 34 in this section. Furthermore, the sealing device 21 has an approximately perpendicular to the longitudinal axis 14 aligned, further sealing surface, which closes in cooperation with the voltage applied to the inner surface or sealing surface 34 sealing surface 33, the interior 10 of the receptacle 5 at the open end face 19 against the outside environment or seals. As a result of the at least regional arrangement of the extension 30 between the projection 32 protruding beyond the sealing surface 33 and the open end 19 of the receptacle 5, adhesion or strong adhesion of the projection 32 directly to the end face 19 can be avoided.

Furthermore, the sealing device 21 may preferably have on the side facing the retaining ring 31, a recess 35 which has approximately the same cross-sectional area as an opening 36, wherein this opening 36 is formed in its dimension such that unimpeded passage of a not shown here Cannula and a subsequent piercing through the sealing device 21 is possible.

The coupling part 26 forming the projection 32 of the sealing plug 22, which protrudes over the sealing surface 33 at least in portions of the circumference flange is supported between the projections 29 and 30 and optionally the retaining ring 31, the distance from each other in two in the direction of the longitudinal axis 14 and perpendicular arranged to this aligned planes and, for example, as at least partially or annular circumferential projections or Arretierfortsätze are formed which a groove-shaped receiving area on the inside of the cap jacket 23 for the projection 32 of the sealing plug 22 form. For secure mounting of the sealing device 21 in the cap 20, it is additionally possible to insert the retaining ring 31 between the projection 32 and the extension 29 which is further distanced from the receptacle 5. In this case, the retaining ring 31 has a larger outer diameter than an extending between the extensions 29 and 30 inner dimension in the direction perpendicular to the longitudinal axis 14. Similarly, the diameter of the opening 36 of the retaining ring 31 is smaller than a largest outer dimension of the projection 32 in a plane perpendicular to the longitudinal axis 14. However, this outer dimension of the sealing device 21 is dimensioned so that it is greater than the inner dimension 13 of the inner cross-section and thus of the inner space 10 at least twice the wall thickness 12 of the receiving container 5 After the extension 30, the Forming coupling part 25, having an inner opening width, which substantially corresponds to the inner dimension 13 of the receptacle 5 in its upper end 6, there is a very good support of the projection 32 in the cap 20 and a good seal between the interior 10 of the Receiving container 5 and the receiving device 1 surrounding atmosphere. This inner opening width can also be chosen to be larger than the inner dimension 13 of the receptacle 5, whereby a lateral abutment of the extension 30 on the outer surface 18 of the receptacle 5 is possible.

Above all, the tightness of the closure device 9 for the open end face 19 of the receiving device 1 is further improved if an outer diameter of the sealing device 21 in the region of its sealing surface 33 in the relaxed state outside of the receptacle 5 is greater than the inner dimension 13 of the receptacle 5 in the sealing device 21 facing area.

Furthermore, in the relaxed, unmounted state, a longitudinal or vertical extent of the projection 32 of the sealing device 21 in the direction of the longitudinal axis 14 is greater than a distance of a groove-shaped receiving area or a groove-shaped depression between the two extensions 29, 30 and optionally minus a thickness of the retaining ring 31. Due to the above-described dimensional differences between the groove-shaped receiving area or the groove-shaped recess and the length dimensions of the projection 32 and the thickness of the retaining ring 31 in the direction of the longitudinal axis 14, there is a bias of the projection 32 between the two extensions 29, 30th This simultaneously causes compression and bias of the sealing device 21 with respect to the cap 20 and causes optionally in addition a tight fit of the retaining ring 31 as well as a whopping conditioning of the two end faces of the projection 32 in the region of the two extensions 29, 30th

It is advantageous, furthermore, if the cap casing 23 is designed as a cylinder stump sheath or as a truncated cone casing, whereby an overstretching of the cap casing 23 in the region of the upper end face 19 is ensured.

In addition to the coupling device 28 described above between the cap 20 and the sealing plug 22, a further coupling device 37 is provided between the receptacle 5 and the cap 20, which has been shown here only simplified. The detailed description of the coupling device 37 forming parts takes place in the following figures.

Thus, the cap 20 has two spaced apart in the direction of the longitudinal axis 14 of each other end portions 38, 39, wherein in the illustrated embodiment, the open end portion 39 is arranged across the open end 19 of the receptacle 5 cross and the end face 19 to close or even adjacent the extension 30 comes up. In the position shown here, the end face 19 fits snugly against the surface of the extension 30 facing this. To achieve this applied or almost adjacent position is further provided between the cap 20 and the receptacle 5, a threaded assembly 40. A first part of the thread assembly 40 is disposed on an inner surface 41 of the cap skirt 23 and a second part of the thread assembly 40 on the outer surface 18 of the receptacle 5 extending. It should be noted at this point that the threaded arrangement 40 or the parts forming it have only been shown schematically in this figure in a simplified manner.

In previously known coupling devices between the cap 20 and the receptacle 5 5 parts of a threaded assembly 40 were both in the region of the inner surface 41 of the cap skirt 23 and in the region of the outer surface 18 of the receptacle known, wherein the assembly of the cap 20 and the closure device. 9 with the receptacle 5 either by transferring and applying a torque to the cap 20 and / or the receptacle 5 about the longitudinal axis 14 or brought by a simple Aufschiebevorgang in the direction of the longitudinal axis 14 with each other have been. Thus, in the choice of the first joining possibility by the torque acting on the cap 20 and the receptacle 5, a rotational movement is achieved, wherein by the thread assembly 40, a relative axial movement in the direction of the longitudinal axis 14 was achieved during the Aufschraubvorganges. The rotational movement could be carried out until the open end 19 in the in Fig. 1 shown position has been moved into the interior of the cap 20. In this case briefly described here mounting process, it was always necessary to apply at least one of the components to be assembled with a torque and the associated rotational movement about the longitudinal axis 14, so as to accomplish the Aufschraubvorgang.

The further described joining possibility, namely the overlapping of the closure device 9, in particular the cap 20 on the open end 19 of the receptacle 5 is made possible by the elasticity of the cap 20 and the cap skirt 23, which in turn also the threaded assembly 40 is engaged with each other, However, the full final positioning of the cap 20 relative to the receptacle 5 was not perfectly accessible in all applications. In addition to pushing over or screwing the cap 20 onto the receptacle 5, insertion of the sealing plug 22 of the sealing device 21 into the open region of the interior 10 of the same always takes place. Thereby, the above-described sealing of the inner space 10 with respect to the external environmental conditions in the region between the sealing surface 33 of the sealing plug 22 and the inner surface of the inner space 10 is achieved.

These two known joining options described above have the disadvantage that for screwing or unscrewing the cap 20 on the receptacle 5, a torque must be applied or that when sliding the cap 20 over the threads as a result of the elastic deformation of the cap 20 and des Cap casing 23 not in all cases, the cap or closure device 9 has taken the fully patched end position or even damage to the threads have occurred.

In the Fig. 2 are the according to the Fig. 1 shown components for assembly to form the receiving device 1, namely the closure device 9 with the open here end 6 of the receptacle 5 in a still separated position, Again, to avoid unnecessary repetition, refer to the detailed description of each component on the previous Fig. 1 is referred to or referred to. Likewise, for the same parts the same component designation as in the previous Fig. 1 used.

In the region of the open front side 19 of the receptacle 5, a first part of the thread assembly 40, such as a thread 42, is shown in simplified form. In the cap 20 shown in half section is on the inner surface 41 between the receiving container 5 facing end portion 39 and the extension 30, a further part of the thread assembly 40, such as another simplified thread 43 shown also shown.

The receptacle 5 is held by means of a holding device 44 shown in a preferred vertical position shown here, wherein it is additionally possible to support the closed here end 7 of the receptacle 5 to a support surface 45 shown in simplified form.

In the illustration of the cap 20 selected here, the sealing plug 22 has been omitted for the sake of better clarity, in order to make the thread arrangement 40, in particular the thread 43 shown here, more readily apparent. Thus, for the assembly or joining process, the cap 20 with the sealing plug 22 arranged therein can be applied to the end 6 of the receiving container 5 open here by means of devices or devices, not shown in detail. Assembly machines or similar from the known prior art manufacturing facilities are placed.

Furthermore, a part of a mounting device 46 is shown here in simplified manner above the cap 20, which in the direction of the longitudinal axis 14 according to the double arrow in the direction of the receptacle 5 or in the opposite direction by means of one or more adjustment means not shown here via adjusting means in its position relative to the stationary held receptacle 5 is designed to be adjustable or are. This mounting device 46 may be formed for example by a corresponding pressure plate, which by means of known adjusting means, such as a cylinder-piston assembly, spindle drives, gear arrangement, magnetic or hydraulic drives, etc. in the predeterminable movement is offset. Both a simple but also multiple arrangement is possible.

Between the mounting device 46, in particular the pressure plate, and facing away from the receptacle 5 end portion 38 of the cap 20 is further simplified a thrust bearing 47 is shown, with which it is possible, via the actuating means or the mounting device 46 impacted on the cap pressure force in cooperation with the threads 42, 43 of the threaded assembly 40 to bring the cap 20 in a relative to the receptacle 5 relative rotational or pivotal movement or to generate this and so to achieve the joining operation or assembly of the closure device 9 with the receptacle 5. In this case, several of these thrust bearing 47 may be kept in a corresponding division of the pressure plate, which can be done in a corresponding multiple arrangement of units to be mounted of the receiving devices 1 space saving the joining or assembly process.

By applying a pure compressive force in the direction of the longitudinal axis 14 and the implementation of this compressive force on the cooperating parts of the thread assembly 40, the relative rotational or pivotal movement and associated screwing the closure device 9 is effected on the receptacle 5.

In this embodiment shown here, the threads 42 project beyond the outer surface 18 of the receptacle 5 in the direction away from the longitudinal axis 14 direction. The first threads 43 of the thread assembly 40 in the region of the inner surface 41 of the cap 20 and the cap jacket 23 protrude in the opposite direction, ie, starting from the inner surface 41 in the direction of the longitudinal axis 14. In the joining or assembly position, the individual co-operating threads 42 and 43 overlap.

In this insertion process is still on it to make sure that the sealing plug 22, not shown here with his inserted into the interior 10, or as this from the Fig. 1 can be seen already used plugs 48 always assumes a sealing position relative to the receptacle 5. Likewise, attention must be paid to a perfect retention of the sealing surface 33 of the plug 48 superior projection 32 within the cap 20.

As already described above, the plug 48 of the sealing plug 22 inserted into the interior 10 has a larger outer dimension in its untensioned state than the receptacle 5 in the area to be used, whereby in selecting the pressure force to be used for overcoming the resistance due to the between the plug 48 and the inner wall of the interior 10 caused friction is considered. As a result, the pressure force to be used for generating the relative rotational or pivoting movement between the closure device 9 and the receptacle 5 should be between 10 N and 50 N in size.

To facilitate the insertion movement, it is advantageous if, prior to assembly, at least one component forming the receiving device 1 is applied at least in regions in the region of the coupling device 37 to a coating (not illustrated here). For example, this coating can be applied to the part of the thread arrangement 40 formed on the receptacle 5 and / or to the part of the thread arrangement 40 arranged in the cap 20 and / or to at least one of the mutually facing sealing surfaces 33, 34 in the region of the plug 48 or Receiving container 5 may be applied. This coating serves to reduce the friction between the components to be assembled. It is possible, e.g. to choose different coatings in the range of the thread assembly 40 and between the sealing plug 22 and the receptacle 5.

The coating can be applied to at least one component forming the receiving device 1 (closure device 9 with cap 20 and sealing device 21 or receiving container 5). This is preferably applied in the region of the coupling device 37 at least in regions, whereby this can be done on the part of the thread arrangement 40 formed on the receptacle 5 and / or in the cap 20. Not only the threads 42, 43 of the thread assembly 40 but also at least partially the inner surface 41 of the cap skirt 23 and / or at least partially the outer surface 18 of the receptacle 5 may be provided with the coating at least in the region of the thread assembly 40. However, this coating can also be applied to the inner surface 18 of the receptacle 5 facing the sealing surface 33 of the plug 48 of the sealing device 21, which is facing the sealing surface 33 of the plug 48 of the sealing device 21. It is also advantageous if the coating in the respective coating area is continuous or continuous is formed with a predeterminable layer thickness.

Before the application of the compressive force (F) is one of the components to be assembled (closure device 9, in particular cap 20, or receptacle 5) relative to the other of the components to be assembled (receptacle 5 and closure device 9, in particular cap 20) relative to this by free rotation to pre-position the common longitudinal axis 14. This is done by holding one of the two components, wherein in the interaction of the threads 42, 43, the mutual alignment takes place and so a perfect repeatable Aufschraubvorgang until reaching the end position can be achieved. During the relative rotational or pivotal movement about the common longitudinal axis 14, the threads 42, 43 of the thread assembly 40 are engaged over the entire length of the Einschraubweges until reaching the fully screwed position with each other.

If the cap 20 and the sealing device 21 inserted therein with the receptacle 5 only pushed in a pure axial movement, an exact mutual alignment of the threads 42, 43 can not be achieved and this can be a Aufeinander- or superimposed of the threads 42, 43 in the plane oriented perpendicular to the longitudinal axis 14 by the elastic expansion of the cap skirt 23 lead. This has the disadvantage that the cap casing 23 sits on the receptacle 5 through the expansion with a higher radial clamping force so that the release of the closure device 9 from the receptacle 5 takes place jerkily and this causes an inadvertent escape of the mixture 2 contained in the interior 10 or of the media 3. 4 result.

As a coating for facilitating the insertion movement of the sealing plug 22 of the sealing device 21, for example, silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides can be used. Likewise, however, also lubricants or lubricant additives can be mixed or introduced into the coating and applied to the cap 20 and / or the receptacle 5 and / or the sealing device 21 for reducing the frictional forces. Thus, the coating comprises at least one lubricant or lubricant additive. Regardless, it is also possible to add at least one lubricant or lubricant additive already provided for the preparation of the cap 5 mixture or granules and the lubricant together melt or soften with the mixture or granules to form the plastic melt in a known form, whereby the lubricant or the lubricant is already part of the cap material or are.

The coating and / or the lubricant additives or the lubricant (s) mixed or incorporated therein and / or dissolved therein can be designed such that they not only greatly reduce the sliding friction between the components to be joined but also increase the static friction prevent accidental release of the components during normal use. As a result, however, a specific opening movement of the closure device 9, in particular the cap 20 from the receptacle 5, can also be carried out simply for a later access to the interior 10, as is described, for example. is necessary for sampling from the collected medium.

Furthermore, in the region of the inner surface 41 of the cap 20 at the thread 43 is shown in simplified form that this to a perpendicular to the longitudinal axis 14 aligned plane 49 a pitch angle 50 from a selected area with a lower limit of 2 °, preferably 3 °, in particular 5 ° , preferably of 8 °, 10 °, 13 °, 15 ° and having an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably of 16 °, 13 ° or 12 °. For test series, pitch angles 50 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable.

Regardless of this, it would also be possible to leave the mounting device 46 and the pressure force not on the cap 20 but on the here closed end 7 of the receptacle 5 act and in the reverse manner, the cap 20 to hold stationary and the receptacle 5 by means of the thread assembly 40th to rotate under the influence of the generated compressive force on the receptacle 5 in the intended position in the cap 20 into it

Instead of here in the Fig. 2 However, another principle of operation can be applied as described below in the assembly Fig. 10 will be shown and described.

In the Fig. 3 to 5 is now the cap 20 to form the receiving device 1 in different Views are shown, again with like parts having the same reference numerals as in the preceding Fig. 1 and 2 be designated.

In this embodiment shown here, the thread assembly 40 is designed to be more continuous in the region of the cap 20. In this case, three threads 42 distributed over the inner surface 41 are preferably provided, wherein thread starts 51 to 53 of the individual threads 43 are arranged offset in the circumferential direction relative to each other by approximately 120 °.

A thread length of the individual threads or threads 43 forming the thread arrangement 40 is equal to or smaller than an inner circumference of the cap jacket 23 in the region of the thread arrangement 40 in the plane 49 aligned perpendicular to the longitudinal axis 14. This is due to the above-described three-start thread advantageous if a thread 43 extends approximately over half the inner circumference of the cap skirt 23. Furthermore, from the presentation, in particular the 3 and 4 to see that the one or more threads 43 are formed projecting beyond the inner surface 41 of the cap skirt 23 in the direction of the longitudinal axis 14. To reduce the friction between the threads 43 shown here in the region of the cap 20 and the previously briefly in the Fig. 1 and 2 described threads 42, it is advantageous if the thread assembly 40, in particular the threads 42 and / or 43, at least partially provided with a coating not shown here. In this case, only the mutually interacting sections of the individual threads 42 and / or 43 may be provided with this coating, not shown.

Irrespective of this or, moreover, it is advantageous for reducing the friction between the threads 42, 43 if they have a surface roughness in the limits of between 0.0125 μm and 0.05 μm at least at the respectively interacting sections.

The individual thread starts 51 to 53 are arranged close to the open and the receptacle 5 facing or cross-end portion 39 and extend due to their above-described slope or the pitch angle 50 to close to the extension 30 zoom. The pitch angle 50 and the circumferential extent of the individual threads 43 is in the present embodiment for the cap 20 of the receptacle 5 for a nominal size of 13 mm, as this is currently a common standard size for the receiving device 1. Likewise, it should be mentioned at this point that the holder of the sealing plug 22, in particular of the projection 32 between the two extensions 29 and 30 may optionally be made with the interposition of the retaining ring 31 but other mounting options are not excluded.

In the Fig. 6 to 9 the receptacle 5 to form the receiving device 1 is shown and described in more detail, again for like parts, the same reference numerals and component names, as in the preceding Fig. 1 to 5 , be used.

By way of introduction, it should be mentioned here that the description for the formation of the threads 42 relates to a receptacle 5, in particular blood sampling tube, with a nominal size in its diameter of 13 mm. In the event of deviations, in particular in diameter, the values described here must be correspondingly transferred to other nominal sizes.

As already described above, it has been found to be advantageous in this nominal size of the receiving device 1, when the thread assembly 40 is more stable, in particular dreigängig, whereby the cap 20 with the receptacle 5 by applying a previously described assembly or joining operation exclusive pressure force in the direction of the longitudinal axis 14 can be connected or coupled.

As if from a synopsis of Fig. 6 and 8th can be seen, the individual threads 42 are arranged to form the threaded assembly 40 on the outer surface 18 of the receptacle 5 evenly distributed. In this case, thread starts 54 to 56 and threaded ends 57 to 59 limit the individual threads 42 in their longitudinal extent over the circumference. So is from a synopsis of Fig. 7 and 8th It can be seen that a pitch angle 60 of the threads 42 for forming the thread assembly 40 relative to a plane 49 oriented perpendicular to the longitudinal axis 14 is selected from a selected range having a lower limit of 2 °, preferably 3 °, especially 5 °, preferably 8 °, 10 °, 13 °, 15 ° and with an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably of 16 °, 13 ° or 12 °. For test series also pitch angle 60 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable. As before described, the threaded assembly 40 is formed more continuous, wherein the second part of the threaded assembly 40 also comprises three distributed over the outer surface 18 and the outer surface arranged threads 42.

As described above, the two selected pitch angles 50, 60 are in the same limits and, in order to achieve a perfect Aufschraubvorgang, each chosen the same size. However, as preferred pitch angles 50, 60, values with lower or upper limits of 3 ° and 20 °, 5 ° and 16 °, 8 ° and 13 °, and 10 ° and 12 ° have also been found, wherein the size of the selected pitch angle 50 , 60 is dependent on the combination of materials of the receptacle 5, the cap 20 and the sealing device 21 and the proposed coating.

The thread starts 54 to 56 of the individual threads 42 are arranged offset in the circumferential direction to each other approximately at 120 °. The same also applies to the threaded ends 57 to 59. Furthermore, directly adjacent to each other thread roots 54 to 56 and threaded ends 57 to 59 each spaced apart in the circumferential direction, whereby a sum of the thread lengths of the thread assembly 40 forming threads 42 in the direction perpendicular to the longitudinal axis 14 aligned Level 49 seen over the circumference equal to or smaller than an outer circumference of the receptacle 5 in the region of the thread assembly 40. Thus, the respectively circumferentially immediately adjacent arranged threads 42 are spaced from each other in the circumferential direction.

In this embodiment shown here, the threads 42 extend between their thread beginning 54 to 56 and their threaded end 57 to 59 seen over the circumference over an angle 61, which may be for example between 50 ° and 80 °. Favor this angle 61 is selected to be in about 65 °. In this section, the threads 42 have their full thread height 62, as shown in the enlarged view of Fig. 9 best seen.

Looking now at the top view of Fig. 8 , it can be seen from this further that the thread 42 in the section of its thread beginning 54 to 56 starting from the full thread height 62 toward the outer surface 18 of the receptacle 5 has a threaded outlet 63 which is formed in its height steadily decreasing. It is the same advantageous if the thread or the threads 42 in the section of their threaded ends 57 to 59, starting from their full thread height 62, towards the outer surface 18 of the receptacle 5 have a further threaded outlet 64, which is also formed in its height steadily decreasing. In most cases, the threaded outlet 63 and / or 64 is formed by a transition radius 65. But this thread outlet can also have any other form technical training to facilitate the joining process. This can also be selected differently depending on the material.

Due to the fact that the individual threads 42 do not overlap or overlap in their longitudinal extent over the circumference and thus the respectively adjacent thread starts 54 to 56 are distanced from the threaded ends 57 to 59, it is possible for the manufacturing process, in particular the Injection molding process to arrange the mold parting plane to form the receptacle 5 in the threads in each case at their highest point or the highest line thereof and between the immediately adjacent threaded starts 54 to 56 and threaded ends 57 to 59 this through a connecting line in the region of the outer surface 18 extending to connect with each other and continue to form the mold parting plane in this connection line. As a result, a significant share of costs can be saved in the production of molds, which also additionally higher cycle times are possible. Such an arrangement of the mold parting plane for the formation of external threads is for example from the US 3,926,401 A as well as the US 2001/0055632 A1 known. A similar training for internal thread is from the DE 30 47 856 C2 . DE 296 18 639 U1 of the US 2,133,019 A . US 4,079,475 A . US 4,188,178 A such as US 5,667,870 A known.

As a result of the threads 42 which are distanced from one another over the circumference and thus do not overlap one another or not overlapping, removal of the receiving container 5 from the molding tool (not illustrated here) can take place through a mold opening in a pure axial direction, ie in the direction of the longitudinal axis 14. As a result, a simpler tool design and a cost reduction associated with it while saving space is achieved. Likewise, the cycle time due to simpler and shorter movements for opening and closing the mold can be achieved thereby. Likewise, a multiple arrangement of cavities for the formation of the receptacle 5 in a single mold is possible and thus may even higher and more favorable output performance can be achieved.

How better of the Fig. 9 can be seen, the thread 42 has seen or seen in its cross section, ie in a parallel to and centrally through the longitudinal axis 14 extending plane, starting from its full thread height 62, toward the outer surface 18 of the receptacle 5 to a mutually different transition region , whereby a thread cross section of the thread 42 is formed asymmetrically in this plane.

The thread 42 has in the region of the outer surface 18 in a nearly parallel direction to the longitudinal axis 14 or in the reference plane described above, a base width 66, which may be 1.3 mm in the present embodiment. Starting from this base width 66, the thread 42 in the considered plane on the open end 19 of the receptacle 5 side facing an exclusive radius 67, which leads, starting from the outer surface 18 toward full thread height 62. In the section of the full thread height 62, the thread 42 has a likewise parallel to the longitudinal axis 14 extending vertex width 68, in the region of the mold parting plane can be arranged to extend. This vertex width 68 is approximately 0.6 mm in the above-described base width 66 of 1.3 mm. On the side facing away from the open end face 19, the thread 42, starting from the outer surface 18, towards the full thread height 62 on a direction towards the open end face 19 inclined transition surface 69, said angle 70 in the present embodiment 5 ° the perpendicular to the longitudinal axis 14 aligned plane 49. Between the parallel to the longitudinal axis 14 extending vertex width 68 and the transition surface 69, a further radius 71 is provided, which has a size of 0.3 mm in the present embodiment.

Due to the different choice of the two radii 67, 71 to obtain an asymmetric thread 42, in which the first radius 67 is selected to be greater than the other radius 71. Thus, the first radius 67 in this embodiment 0.7 mm and passes from starting the outer surface 18 to the parallel vertex width 68 of the thread 42 via. This vertex width 68 of the thread 42 may also be referred to as a vertex surface 72 become.

The apex surface 72 and the transition surface 69, in a view of the thread cross-section can also be referred to as a crest line or transition line or boundary line.

Furthermore, is from the Fig. 7 can still be seen that the thread beginning 54 of the thread 42, in particular the threaded outlet 63 of the same, comes close to close to the open end face 19 of the receptacle 5. This ensures that the joining process or assembly process with the closure device 9, the mutually engaging threads 42, 43 to form the thread assembly 40 up to the full closure position, as shown in the Fig. 1 can be seen, are always in engagement, whereby a clear screwing and unscrewing the closure device 9 from the receptacle 5 is always possible.

In the Fig. 10 is another and possibly independent solution for joining or mounting the receiving device 1 similar to the training as in the Fig. 2 shown. In this case, illustrated components for assembly to form the receiving device 1, namely the closure device 9 are shown with the open end 6 of the receptacle 5 in a still separate position, in turn, to avoid unnecessary repetition, to the detailed description of the individual components on the previous one Fig. 1 to 9 is referred to or referred to. Likewise, for the same parts the same component designation as in the previous Fig. 1 to 9 used.

Also in this illustration, the cap 20 is simplified in half section and shown without sealing device 21, wherein the cap 20 is still seen in a distant position from the receptacle 5 in the direction of the longitudinal axis 14. Likewise, the thread assembly 40 is shown simplified. The reference numerals were analogous to those in Fig. 2 Registered training, wherein, in order to avoid unnecessary repetition, here omitted a detailed description and reference is made to the preceding embodiments and reference is made.

In this embodiment shown here is in contrast to that in the Fig. 2 assembly shown 46, the cap 20 in the region of its outer cap jacket 23 in a receptacle 73 a holding plate 74 on the one hand rotationally fixed about the longitudinal axis 14 and on the other hand held stationary in the direction of the longitudinal axis 14 relative to the holding plate 74. The application of the compressive force (F) is again effected by means not shown here adjusting, such as adjusting means. Again, a multiple arrangement of the receptacles 73 in the holding plate 74 is possible, even advantageous, whereby a plurality of caps 20 or already fully assembled closure devices 9 inserted therein and are held stationary both about the longitudinal axis 14 and in the same direction.

As a result of the here conical or frusto-conical outer surface of the cap 20 and cap jacket 23 and the corresponding opposite trained receiving 73 can be made with respect to tolerances a positional fixation of the cap 20 with respect to the longitudinal axis 14 and in the same direction. However, a sufficient positional fixation is also possible with almost cylindrical caps 20. In this case, an outer surface of the cap 20 that is profiled over the circumference can favor the positional fixation for the assembly or joining process.

Regardless, it would also be possible to perform the support plate 74 divided accordingly and provide in these attacks in the direction of the longitudinal axis 14 to specify a clear longitudinal positioning of the cap 20 and closure device 9 in the holding plate 74 provided in the holding or locking position can. For this purpose, appropriate stops or approaches can be provided, which have not been shown here in detail. By a shared executed holding plate 74 in the area of the receptacles 73 so a clamping and thus radial fixation of the closure device 9 and cap 20 with respect to the longitudinal axis 14 within the holding plate 74 can be achieved.

Due to this selected arrangement, a compelling mutual alignment of the threaded arrangement 40 of the receptacle 5 and the closure device 9 against each other before the joining process is no longer necessary, which also costs for the otherwise necessary alignment operations can be saved here. This cost reduction is not only due to the shortening of the cycle times.

The receptacle 5 is rotatably supported in this embodiment via the thrust bearing 47 on the support surface 45 about the longitudinal axis 14, wherein the axial alignment or pre-positioning of the same with respect to the cap 20 and closure device 9 this is associated with a positioning device 75. In this positioning device 75, a guide hole 76 shown in simplified form is arranged, which ensures, for example, a vertical orientation of the receptacle 5 for the assembly or Fügelage. This guide opening 76 has a sufficient clearance to the outer surface 18 of the receptacle 5 so as to be able to perform about the fixed cap 20 generated rotational or pivotal movement about the longitudinal axis 14 can. In addition, different coatings may be provided on the outer surface 18 facing the inner surface of the guide opening 76, which are not shown here. Likewise, it is also possible to provide the guide opening 76 only partially over the entire outer circumference of the receptacle 5, wherein for a multiple arrangement of receptacles 5 and closure devices 9 but for example only individual vertical webs between the immediately adjacent receptacles 5 may be provided, which ensure a sufficient secure guidance or positioning and rotation or pivoting with respect to the closure device 9 to be joined.

To simplify the automated assembly, it is also possible to provide the thrust bearing 47 or on a movable mounting base, being filled in a separate filling the mounting bracket with a corresponding number of receptacles 5, in a further station to be joined closure devices 9 also in a separate mounting support on which the support plate 74 is required to pivot or rotatably supported, also to load or insert them into the receptacles 73, then subsequently to move the so pre-filled mounting bracket to its own assembly station, in which the joining process according to the invention, namely Application of a pure compressive force to screw together. This has the advantage that a plurality of receptacles 5 and / or closure devices 9 and caps 20 can be pre-loaded independently of one another in the holding plates 74 and / or positioning devices 75 arranged on the mounting supports or workpiece carriers and the joining process in a separate one thereof to carry out a separate assembly station.

As described in detail in the individual figures, the placement process takes place the closure device 9 on the receptacle 5 by a pure implementation of acting in the direction of the longitudinal axis 14 axial force in a relative rotational or pivotal movement between the components to be joined until the maximum Einschraubweg eg by a mechanical stop between the receptacle 5 and the cap 20th and / or the sealing device 21 is limited. By this mechanical definition of the length of the Einschraubweges by at least partially co-operating threads 42, 43 of the thread assembly 40 they are over the entire up or Einschraubweg engaged with each other, which starting from the fully screwed position unscrewing or loosening the closure device 9 of Receptacle 5 can be performed by a relative rotational or pivotal movement between the components to be separated. Due to the uniquely predetermined relative position, in the fully screwed position between the cap 20 and the receptacle 5 necessary for releasing Abschraubweg is determined by the circumferential length or the angular extent of the overlapping or cross threads 42, 43 and takes place in an opposite relative movement between the components.

This unscrewing operation is controlled by the at least partially co-operating threads 42, 43, wherein in addition also held on the coupling device 28 in the cap 20 sealing device 21 also mitentfernt simultaneously removed from the receptacle 5 and is lifted. For a simultaneous secure decrease or separation of the closure device 9 from the receptacle 5 is possible. Furthermore, a jerky opening or loosening of the sealing device 21 is avoided by the cooperating threads 42, 43 from the receptacle 5, wherein an inadvertent leakage of stored in the interior 10 of media 3, 4 and the mixture 2 is avoided. As a result, the handling of the operating personnel is safer, which possible infection by leaking subsets and thus possible connected infections are ignored. By this predeterminable screwed-on end position but also a decapping of the closure device 9 from the receptacle 5 by mechanical devices or devices is possible, as always a predeterminable Abschraubweg and thus defined, relative rotation or swivel angle between the components to be separated is clearly defined.

In the Fig. 11 are different training options of the receptacle 5 in a simplified representation of a single figure, but these can also be arbitrarily combined with each other as well as with each other as well as with the training options described above. For better clarity, the illustration of the closure device 9 is omitted in this figure. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 10 referred or referred. In addition, the same reference numerals or component designations are used for the same parts as in the preceding FIG.

In addition to the previously in the Fig. 1 to 10 described embodiments, it is also possible to use the receptacle 5 in conjunction with the closure device 9 not shown here for a receiving device 1. In this illustration, a separating device 77 is provided, which is to be inserted into the receptacle 5 before closing the inner space 10 and is shown here in a position distant from the receptacle 5. In this case, this separating device 77 according to the statements, as shown in the WO 02/078848 A2 the same applicant is described to be formed. For the special design of the separator, the receptacle and the closure device is on the aforementioned WO 02/078848 A2 Reference is made and incorporated this disclosure in the present application. The selected terms are analogously to the terms and representations chosen here.

The separating device 77 is inserted into the inner space 10 or a receiving space 78 in the region of the open end face 19 in the receptacle 5 and is there in the so-called starting position, in which after completion of the receptacle 5 with the closure device 9 also additionally simultaneously or even before the interior 10 is lowered to a lower pressure relative to the ambient pressure, in particular evacuated is. The filling of the receiving device 1 is carried out in a conventional manner, for example in the form of a blood sample, with the associated piercing of the sealing device 21 with a cannula, not shown here, whereby the in the Fig. 1 shown mixture 2 from the media 3 and 4, in particular blood, flows through the flow channel or connection opening through the separator 77. Thereafter, the separation of the mixture by centrifuging, as already described in detail in the WO 02/078848 A2 has been described. In the sealing position of the separator 77 within the The receptacle 5 is located in the so-called working position, which is dependent on the total filling volume of the receptacle and the volume proportion of the components of the mixture to be separated 2. Usually, the working position in about half of the longitudinal extent of the available receiving space 78 of the receptacle. 5 be elected.

In the region of the starting position adjacent to the end 6 of the receptacle 5 for the separating device 77 to be inserted into the inner space 10 or the receiving space 78, different embodiments of the retaining device 79 are shown for the latter. It is shown here in the right part of the figure that the retaining device 79 by at least one over the circumference of an inner surface 80 in the direction of the longitudinal axis 14 projecting projection 81 and / or by at least partially over the circumference of the inner surface 80 in the direction the longitudinal axis 14 projecting web 82 is formed. In this case, both the projection 81 and / or the web 82 can only be arranged in a continuous manner over the circumference and possibly also continuously over the entire circulation of the inner surface 80 over certain regions.

In the upper left area of the here Fig. 11 a further embodiment of the retaining device 79 is shown, which is formed by a reduction of the inner dimension 13 of the receiving space 78, starting from the open end face 19, the sealing surface 34 for the sealing device 21, not shown here, in particular the sealing surface 33 of the sealing plug 22, is trained. This reduction can be effected by, for example, starting from the end 6 of the receptacle 5 to the retaining device 79, the normal wall thickness 12 of the receptacle 5 and from the retainer 79 in the direction of the other end 7 has a greater wall thickness, the magnification of the Wall thickness 12 by an offset of the inner surface 80 in the direction of the longitudinal axis 14 takes place. Regardless, it is also possible to choose the wall thickness 12 of the receptacle 5 between the starting position and the other end 7 in the range of the usual wall thickness 12 and only the wall thickness between the starting position and the open end 6 of the receptacle 5 form less.

Depending on the design of the retaining device 79 is a positional positioning of the separating device 77 in the direction of the longitudinal axis 14 until reaching a predeterminable centrifugal force, in which the restraining forces are overcome and the displacement of the separating device 77 takes place relative to the receptacle 5 up to reaching the working position, predeterminable.

To achieve a different secure positioning or relative position fixation of the separating device 77 in the region of the starting position, the retaining device 79 between the receptacle 5 and the separator 77 by a groove-shaped recess, not shown here, which all around the inner circumference of the inner surface 80 in this is recessed, be formed.

To achieve a secure positioning or relative positional fixation of the separating device 77 in the region of its working position, a positioning device 83 can be arranged between the receiving container 5 and the separating device 77, which is preferably formed by a mechanically acting stop. This positioning device 83 can be formed, for example, by reducing an inner dimension 84 of the receiving space 78 or inner space 10, optionally forming a stop surface 85 oriented approximately perpendicular to the longitudinal axis 14. At this stop surface 85, both the sealing device arranged in the first end region of the separating device 77, in particular the sealing lips, as well as the further end region thereof or its components can be brought into abutment. Thus, a sealing, in particular liquid-tight sealing of the separate media 2, 3 is achieved after completion of the centrifuging process over a longer storage life. This positioning device 83 thus forms a mechanical stop for the separating device 77 for terminating the relative adjustment movement relative to the receiving container 5 in the direction of the longitudinal axis 14 toward the further end 7.

The reduction of the interior 10, starting from the starting position towards the working position or between the first and further end 6, 7, is also realized in this receptacle 5 shown here and forms a control cam for the self-closing of the flow channels or in the region of the separator 77 off. The tapering of the receptacle 5 described above in its inner space 10 or receiving space 78 between the two mutually spaced planes 15, 16 may be between 0.1 ° and 3.0 °, preferably between 0.6 ° and 1.0 °. For a receptacle of nominal size 13 mm (diameter) with the nominal length 100 mm may be the cone or cone angle relative to the longitudinal axis 14 and the outer surface 18, for example 0.34 °. This conical or cone angle is chosen to be constant over the entire outer longitudinal extent between the two ends 6, 7. The conical or cone angle of the inner surface 80, also with respect to the longitudinal axis 14, can also be 0.46 in the first partial area between the first end 6 and the positioning device 83, for example 0.46 ° and between the positioning device 83 and the plane 16 ° amount. Likewise, it is also possible to form the portion of the sealing surface 34 cylindrically, so as to insert the sealing plug 22 of the sealing device 21 - see Fig. 1 - to facilitate.

In the Fig. 12 to 16 is another possible and possibly independent training of the receptacle 5 for forming a closable with a closure device 9 receiving means 1 for body fluids, tissue parts or tissue cultures shown, again for like parts, the same reference numerals or component names, as in the preceding Fig. 1 to 11 be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 11 referred or referred. It need not be emphasized that this embodiment of the receptacle 5 described here but also with all other forms contained in this description can be combined with each other arbitrarily.

This receptacle 5 in turn serves as a receptacle 1 for body fluids, tissue parts or tissue cultures, in particular for the use of a mixture to be separated 2, consisting of at least the, a different density having media 3, 4, as already in the Fig. 1 has been shown simplified and described. Instead of the thread arrangement 40 described above, in the area of the open end 19 in the area of the first end 6 evenly distributed over the circumference are several, in the present case three, the outer surface 18 projecting beyond the direction away from the longitudinal axis 14 protruding extensions 86, such as this can already be deduced from the known state of the art. But it would also be possible, instead of the extensions 86, to use the previously described threads 42 in connection with the threads 43 in the cap 20, as already described in detail in the preceding Fig. 1 to 10 has been explained. Starting from the open end face 19 extends in the region of the interior 10, the sealing surface 34, which serves to bear the sealing surface 33 of the sealing stopper 22 of the sealing device 21 not shown here. Following this, the further area of the interior 10 for the insertion of in the Fig. 11 simplified illustrated separating device 77 provided as best of the Fig. 13 can be seen. In order to facilitate the filling process of the mixture through the or in the separation device or through this formed flow channel or connection opening, at least one through-flow channel 87 in the region between the container wall 11 of the receptacle in the starting position of the inserted or deployable separation device 77 5 and the separator 77 is formed. This flow-through channel 87 serves to spend the remaining in the interior 10 between the separator 77 and the other end 7 remaining amount of air to the separator 77 over into the interior 10 between the separator 77 and sealed by the sealing device 21 interior 10. Likewise, the flow-through channels 87 can also serve to allow residual quantities of the mixture 2, which have not flowed through the flow channel or the connection opening in the region of the separating device 77, also into the interior 10 of the receiving container 5 formed between the separating device 77 and the further end 7 spend.

As if from a synopsis of Fig. 12 to 16 can be seen, here the flow-through channel 87 is formed by at least one recessed 88 formed in the inner surface 80 of the container wall 11. This recess 88, recessed in relation to the inner surface 80, has, starting from the inner surface 80 in the radial direction towards the outer surface 18, a depth 89 between 0.1 mm and 1.0 mm, preferably between 0.2 mm and 0.5 mm , on. Preferably, a plurality of distributed over the inner circumference arranged recesses 88 are provided, in which case a symmetrical division in relation to the longitudinal axis 14 over the inner circumference is advantageous. However, it would also be possible to arrange the recess 88 continuously over the inner circumference and thus to form it in the form of a groove-shaped depression or hollow cylinder.

The recess 88 has a coaxial with the sealing surface 34 arranged base surface 90, which thus limits the recess 88 in depth. Between the base surface 90 and at least one of those in the direction of the longitudinal axis 14 spaced from each other boundary surfaces 91, 92, a first transition surface 93 is arranged in each case. Furthermore, at least one further transition surface 94 can be arranged between one of the boundary surfaces 91, 92 of the recess 88, distanced from one another in the direction of the longitudinal axis 14, and the inner surface 80. These two transition surfaces 93, 94 may be selected such that they already form the mutually distanced boundary surfaces 91, 92. These boundary surfaces 91, 92 are in the direction of the longitudinal axis 14 as viewed across a longitudinal extent 95 distanced from each other. In this case, the longitudinal extent 95 ends before the sealing surface 33 of the sealing plug 22 zuwendbaren sealing surface 34. In the direction away from the longitudinal extent 95 of the recess 88 can reach a maximum until reaching the working or disconnected position of the separator 77. Preferably, however, this is chosen to be shorter, only to form the flow passage 87 in the region of the inner surface 80 and the separator 77 during the filling process and only after a slight adjustment of the separator 77 towards its working position, only a passage of a component of the mixture through the To allow flow channel or the connection opening in the region of the separator 77. Otherwise, a sealing contact of the sealing lips of the separating device 77 on the inner surface 80 of the receptacle 5 to achieve a perfect separation result is preferable.

In a possible embodiment, five recesses 88 are provided in the receptacle 5 over the inner periphery, which have a size or extent in the circumferential direction of 1.9 mm seen at a depth of 0.4 mm. These recesses have in the direction of the longitudinal axis 14, the longitudinal extent 95 of 3 mm. It is essential in the choice of the depth 89 of the recess 88, that in this area, the container wall 11 still has sufficient strength that is sufficient to ensure the shelf life of the receiving device 1 in its unused state (maintenance of the vacuum). Here, depending on the manufacturer, a period of e.g. Guaranteed 18 months, within which the interior 10 preset vacuum is maintained. In this design, attention must be paid to the oxygen and water vapor permeability of the material, especially in this area.

How best of all Fig. 12 and 16 can be seen limit parallel to the longitudinal axis 14 aligned boundary surfaces 96, 97, the recess 88 seen in the circumferential direction. In cooperation of the two boundary surfaces 96, 97 and the depth 89 of the recess 88, a flow cross-section 98 is limited or fixed, which is dimensioned such that both subsets of the mixture 2 and residual amounts of air can flow simultaneously, but in the opposite direction, without a Clogging or laying of this flow-through channel 87 and the flow-through channels 87 associated therewith. In this case, the minimum flow cross-section 98 of the at least one flow-through channel 87 in the plane 49 oriented perpendicular to the longitudinal axis 14 is at least 0.4 mm ² . This size represents the minimum extent of that cross-sectional area which is necessary when using the receiving device 1 as a blood sampling tube to allow a proper flow of a portion of the mixture or medium to be filled and a simultaneous displacement of residual amounts of air in the opposite direction of flow.

In order to reduce or prevent the adhesion or deposition of constituents of the mixture 2 in the region of the recess 88, in particular of the boundary surfaces 91, 92 and / or 96 or 97, it is advantageous if at least one of these boundary surfaces 91, 92 , 96, 97 and transition surfaces 93, 94 is concavely curved. But it would also be possible, one of these boundary surfaces 91, 92, 96, 97 and / or transition surfaces 93, 94 planar form. For the removal of the receptacle 5, in particular its core for forming the interior 10, it is advantageous if the boundary surface 91 closer to the open end 19 or the transition surfaces 93, 94 form a relatively shallow transition towards the sealing surface 34 or inner surface 80 like this best of all Fig. 15 can be seen. In this case, the boundary surface 91 is planar and the transition surface 94 arranged between the latter and the sealing surface 34 or inner surface 80 is convex, in particular by a radius, and the transition surface 93 formed between the base surface 90 and the boundary surface 91 is concave, preferably also by a radius. educated.

In order to reduce or prevent adhesion of the constituents of the mixture 2 in the region of the inner surface 80, in particular of the flow-through channel 87 or the recess 88, it is advantageous if this surface has a surface structure which makes adhesion more difficult or prevented. Here, in particular, a surface structure according to the "lotus flower effect" can be used. This is just in this very sensitive area a deposition or adhesion of residues of the mixture 2 prevented. However, this repellent surface structure can also be provided on the sealing device 21, the sealing surfaces 33, 34, the cap 20 and the separating device 77, wherein only a region-wise arrangement is possible.

In the FIGS. 17 and 18 In each case, a further and possibly independent training of the cap 20 and the receptacle 5 is shown in simplified form, again in order to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 16 is referred to or referred to. Likewise, the same reference numerals and component names for the same parts, as in the preceding Fig. 1 to 16 , used.

That's how it shows Fig. 17 the cap 20 with its cap skirt 23, wherein on the longitudinal axis 14 facing inner surface 41 in the region between the receiving container 5 facing end portion 39 and the extension 30 parts of the threaded assembly 40 are formed. The one or more threads 43 are seen here over their longitudinal course, formed by a plurality of circumferentially successively arranged and spaced from each other, first thread segments 99. The shape of the thread segments chosen here is chosen only as an example for a variety of possible embodiments and these can have a wide variety of spatial forms. Thus, these thread segments 99 also project beyond the inner surface 41 of the cap jacket 23 in the direction of the longitudinal axis 14.

In the Fig. 18 is the thread 42 on the receptacle 5 also seen over its longitudinal course formed by a plurality of circumferentially successively arranged and spaced from each other further thread segments 100. These thread segments 100 may in turn have a variety of spatial forms and the outer surface 18 of the receptacle 5 project beyond the direction of the longitudinal axis facing away.

Furthermore, in the Fig. 17 in the region of the thread 43 shown in dashed lines yet simplified that the previously described in detail coating or a lubricant or a lubricant additive can be stored in at least one recess 101 in the region of the thread 43. The recesses 101 are simplified only schematically and can be arranged, for example, between the individual thread segments 99 in the cap casing 23 and / or also directly in the region of the thread 43. Thus, for example, several recesses 101 distributed over the circumference in the cap casing 23 and the threads 43 may be arranged, which serve to receive the coating and / or the lubricant or a lubricant additive.

In the Fig. 19 is shown a further possible and possibly independent formation of the cap 20 in conjunction with the sealing device 21 inserted therein, again to avoid unnecessary repetition, to the previously detailed description in the Fig. 1 to 18 is referred to or referred to. Likewise, the same reference numerals and the same component designations are used for the same parts, as in the preceding Fig. 1 to 18 used.

As already described above, the two projections 29, 30 distanced from one another in the direction of the longitudinal axis 14 and optionally the retaining ring 31 inserted therebetween delimit the groove-shaped receiving region for the projection 32 of the sealing device 21 on the inside of the cap jacket 23. In this section of the groove-shaped receiving region in this embodiment, in the cap casing 23 at least one enforcement 102 is arranged, which forms an opening or an opening or even form a recess in the cap casing 23.

In this enforcement 102 projects in the inserted or assembled state of the sealing device 21, a projection 32 superior projection 103 into it, which in addition to the holder or coupling of the sealing device 21 in the direction of the longitudinal axis 14 against rotation or further coupling of the sealing device 21 against the cap 20 forms about the longitudinal axis 14. This enforcement 102 may have a variety of cross-sectional shapes and be formed, for example, round, polygonal, oval, etc., wherein the enforcement is preferably a window-like opening in the cap jacket 23. If, viewed over the circumference, a plurality of openings 102 are provided in the cap casing 23, it is advantageous if they are distributed uniformly over the circumference. Thus, the individual projections 103 projecting through the passages 102 may also project beyond the outer surface of the cap jacket 23 and at the same time as preventing the entire receiving device from rolling or rotating be used on a flat or sloping surface. If the projections 103 protrude beyond the outer surface of the cap jacket 23 to a certain extent, they can also simultaneously serve as a handle or grip element for unscrewing the entire closure device 9 from the receptacle 5 and thus improve handling or even make it safer.

Another additional and possibly independent training of the cap 20 is simplified in the Fig. 19 represented here, in which the receptacle 5 zuwendbaren and cross-end portion 39 of the cap 20 is a preferably all-round, and the end portion 39 superior apron-shaped protective element 104 is shown simplified. This apron-shaped protective element 104 can only be arranged or formed on the cap jacket 23 in regions over the circumference, but preferably all around. It is possible to form the protective element 104 as a separate component on the cap casing 23 or to form the protective element 104 as an integral part of the cap casing 23. As shown in simplified form here, the protective element 104 has a continuously decreasing cross section with increasing distance from the end region 39.

An inner diameter 105 of the protective element 104 may correspond approximately to the outer diameter or the outer dimension of the receptacle 5, optionally in addition, the projection of the threads 42 on the outer surface 18 of the receptacle 5. This protective element 104 serves to form an additional leakage protection or splash protection for a user of the receiving device 1 in order to avoid unwanted contact when taking off the closure device 9, which is possible by ejecting the contents from the receiving container 5. As a result, contagions or infection of the operating personnel can be reduced or avoided at all.

In the Fig. 20 is another possible and possibly independent training of the receptacle 5 is shown, again to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 19 is referred to or referred to. Likewise, the same reference numerals and component names are used for the same parts, as in the preceding Fig. 1 to 19 , used.

The receptacle 5 shown here is again preferably designed for insertion of a separation device 77, not shown here, and instead has the in the Fig. 12 to 16 shown and described recess 88 for forming the flow passage 87 in contrast to at least one, but preferably several, the inner surface 80 of the receptacle 5 in the direction of the longitudinal axis 14 projecting ribs 106 on. The ribs 106 are web-shaped and preferably aligned parallel to the longitudinal axis 14. In most cases, a plurality of ribs 106 distributed over the circumference are arranged on the inner surface 80 of the container wall 11 and form between them - so seen in the circumferential direction - the flow-through channels 87 from. The separation device 77, not shown here, abuts the boundary surfaces of the ribs closer to the longitudinal axis 14 and thus faces, whereby between the separating device 77, the circumferentially spaced apart ribs 106 and the inner surface 80 of the container wall 11 or the flow channels 87th is limited or are. A minimum cross-section of this flow-through channel 87 can again amount to at least 0.4 mm ² , but can also be made larger.

In the Fig. 21 and 22 possible and possibly independent embodiments for applying the coating already described above are shown, again for the same parts the same reference numerals or the same part designations as in the Fig. 1 to 20 be used. Likewise, to avoid unnecessary repetition, the detailed description of the Fig. 1 to 20 referred or referred.

That's how it shows Fig. 21 a possibility for applying the coating on the sealing surface 33 of the sealing device 21, in particular of the plug 48, which is the inner surface 18 of the receptacle 5 in the inserted state facing and thereby seals the inner space 10 from the outside atmospheric environment. In this case, the projection 32 of the sealing device 21 may be held in a holder 107 shown here only in a simplified manner, wherein the sealing surface 33 to be coated is assigned a coating element 108 shown in a simplified manner. This is independently rotatable about a simple axis of rotation about its own axis and / or also additionally coupled with a drive. The holder 107 with the sealing device 21 performs a rotational movement and it is by the system of the coating element 108 on the surface to be coated - here the sealing surface 33 - the coating material of the coating element 108 transmitted from. On the presentation of the drive was omitted for better clarity. However, it would also be possible to drive the coating element 108 and to let the sealing device 21 held in the holder 107 rotate together with it through the system. It is also a superposition of the rotational movement with a movement gem. Registered double arrow in the direction of the longitudinal axis 14 of the sealing device 21 possible.

Furthermore, a supply device 109 is assigned to the coating element 108 for storing the coating agent. When a liquid coating agent, e.g. Silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides or the like used, this is stored in a container 110 and fed via a feed line 111, in which also a metering element 112 may be arranged. The thereby supplied amount may be supplied dropwise in dependence on the number of pieces and the surface to be coated of the sealing plug 22 to be coated. In this case, cycle times can be selected in the supply line between 50 and 300 pieces, which means that after reaching the coated number of sealing plug 22 again a predeterminable unit of quantity of the coating composition, e.g. a drop or more is supplied. The coating element 108 stores the coating agent supplied to it and delivers it to the surface or body to be coated in order to form the coating.

In addition, it may be advantageous if in the surface to be coated - here the sealing surface 33 - receiving openings 113, such. Pores, distributed over the sealing surface 33 are provided in order to bring in these additional coating agent for forming the coating can. This causes after the first insertion of the plug 48 into the receptacle 5 and a first removal, if the coating on the sealing surface 33 is already partially scraped, further coating agent is stored for a further easy insertion process.

However, it would also be possible to insert the sealing device 21 in a preferably rectilinear guide rail such that the projection 32 rests on the guide rail, the plug 48 projects through the guide rail and the sealing surface 33 is brought into contact with the coating element 108 and thus transfers the coating agent becomes. In this case, the coating element 108 may be formed as a strip-shaped component, which rests on the sealing surface 33 on one side and by a parallel movement of the coating member 108 to the guide rail, a combined rotational and longitudinal movement of the sealing device 21 is effected relative to the guide rail. The sealing device 21 rotates on the one hand about its longitudinal axis 14 and on the other hand it is moved along the guide slot. In this case, a plurality of sealing devices 21 may preferably be arranged at a distance from each other in succession in the guide slot, whereby then a plurality of sealing devices 21 can be coated simultaneously in a coating movement.

In the Fig. 22 a possibility for applying the coating on the inner surface 18 of the receptacle 5 in the region of the open end face 19 is shown. The surface to be coated, in particular the sealing surface 34, may correspond to that which faces the sealing surface 33 of the plug 48 in its inserted state.

On an outer side of a mandrel 114, the mandrel 114 radially protruding coating element 108 is arranged at approximately trained receptacle 5, wherein this is to be matched in its outer dimension to the inner dimension 13 of the receptacle 5. The coating element 108 is held fixed in a groove-shaped recess 115 on the mandrel 114 and projects beyond the mandrel 114 in the radial direction. Thus, an exclusive contact of the surface 18 to be coated of the receptacle 5 with the coating element 108 can be achieved with aligned alignment. The coating element 108 is tubular in this case. The feed and the quantitative dosage can be as described in the Fig. 21 respectively. Also, a superimposed movement of the mandrel 114 in the direction of the longitudinal axis 14 as possible around them, as indicated by corresponding double arrows.

The application of the coating to the outer surface 18 of the receptacle 5 in the region of the thread arrangement 40 can be carried out analogously to the coating on the inner surface 18, in which case the coating element has an opening adapted to the outer dimension of the receptacle 5.

On the inner surface 18 of the receptacle 5, for example, at a rate of 300 coatings per replenishment, a silicone amount between 0.1 mg and 0.001 mg, preferably between 0.07 mg and 0.04 mg, in particular of 0.055583 mg. At the outer surface 18 in the region of the thread arrangement 40, for example, with a cycle number of 60 coatings per replenishment, a silicon amount of between 0.6 mg and 0.1 mg, preferably between 0.4 mg and 0.2 mg, in particular of 0.27917 be applied mg. These weights refer to a nominal size of the receptacle 5 of 13 mm and only those surface areas which are also provided with the coating. The coated surface area on the receiving container 5 is about 75 mm ² at the immersion depth between 1 to 2 mm on the inner surface and about 70 mm ² on the outer surface. At the plug 48 of the sealing plug 22 an area of about 146 mm ^{2 is} coated.

In the Fig. 23 and 24 is a further possible and possibly independent training of the receiving device 1, in particular the closure device 9 for the receptacle 5, shown in an enlarged, schematically simplified representation, in turn, the same parts the same reference numerals or component names, as in the previous Fig. 1 to 22nd be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 22nd referred or referred.

In this embodiment shown here, the projection 32 of the sealing device 21 in the region of the cap 20 on the one hand by the projecting beyond the inner surface 41 of the cap jacket 23 in the direction of the longitudinal axis 14 extension 30 and on the other hand by the distance therefrom, further extension 29 and optionally in between arranged retaining ring 31 in its position relative thereto, as already detailed in the Fig. 1 has been described.

In contrast to the illustration for Fig. 1 Here, the extension 30 is arranged laterally next to the outer surface 18 of the receptacle 5 in the region of the open end face 19 and may also be formed adjacent thereto. The plug 48 of the sealing plug 22 has in its central region - ie in the region of the longitudinal axis 14 - in the direction of the same thickness or thickness of about 3.0 to 4.0 mm, said thickness depends on the selected material of the sealing plug 22, in particular of the plug 48, is. This is, as described above, formed from a re-closing after the piercing process material, so even after the piercing the closure of the passage opening of Cannula or needle and thus a passage of liquid or gaseous substances secured over a predeterminable period of time to prevent.

The plug 48 has the sealing surface 33 facing or facing the inner sealing surface 34 of the receptacle 5, which in this embodiment is shorter in the direction of the longitudinal axis 14 relative to the previously described embodiments. Thus, the sealing surface 33 can be formed shorter in its longitudinal extent in the direction of the longitudinal axis 14, for example, by half. But it is also an extent in this direction between 1.0 mm and 2.5 mm, preferably 1.5 mm possible.

By reducing the sealing surface 33 in the region of the plug 48, a further sealing surface 116 is provided in the region of the radially projecting shoulder 32 at the end face 19 facing the open end 19 of the receptacle 5 in the fully inserted position of the sealing plug 22 cooperates in the interior 10 of the receptacle 5. This makes it possible, at least partially, to compensate for the reduction of the sealing surface 33 in the region of the plug 48. This has in the inserted state of the sealing plug 22 has the advantage that despite the reduction of the inner surface 18 and the sealing surface 34 of the receptacle 5 facing sealing surface 33 an additional sealing surface 116 in the region of the open end face 19 is created. Furthermore, the shortening of the sealing surface 33 on the stopper 48, the relative displacement between the receptacle 5 and the closure device 9 is reduced so far that, as best of the Fig. 24 can be seen, with still engaged threads 42, 43 of the thread assembly 40 between the plug 48, in particular the sealing surface 34, and the open end 6 of the receptacle 5 in the region of the sealing surface 34 and the end face 19 at least one channel 117 is formed or is released. Thus, at least one channel 117 is formed between the sealing device 21 and the open end 6 of the receptacle 5 in still engaged threads 42, 43 of the threaded assembly 40 on the receptacle 5 and the cap 20. Thus, a pressure equalization between the interior 10 of the receptacle 5 and the external atmospheric environment is possible in still-overlapping position between the cap 20 and the receptacle 5, as shown schematically by a corrugated arrow in the Fig. 24 is shown.

By still in this position engaged threads 42, 43 of the threaded assembly 40 can be made to reach or formation of the channel 117 a controlled extension movement of the plug 48 from the receptacle 5, in which case even on a corresponding holder of the entire sealing plug 22nd in the cap 20 is pay attention. Would this mutual support is not sufficient, the sealing plug 22 would remain on or in the receptacle 5 and only the cap 20 are separated from the sealing plug 22 deducted. The extension 30, which is preferably arranged to run continuously over the entire inner circumference of the cap jacket 23, has in this embodiment shown here a clear inner width 118 which corresponds approximately to an outer dimension 119 of the receptacle 5 in the region of the open end 6. The smaller the difference between the clear width 118 and the outer dimension 119, the smaller the gap between the extension 30 and the outer surface 18 of the receptacle 5 in the screwed-on position of the closure device 9. In this case, the extension 30 may also be adjacent to the outer surface 18 of the receptacle 5 may be formed, in which case the inner clear width 118 of the extension 30 corresponds to the outer dimension 119 of the receptacle 5. If, however, the inner clear width 118 of the extension 30 is selected to be slightly smaller than the outer dimension 119 of the receptacle 5, there is a slight interference fit between the cap 20 and the receptacle 5. In these cases, then for the formation of the channel or channels 117 of the extension 30 viewed over the circumference formed at least partially interrupted or provide recesses on the receiving container 5 facing or adjacent surface.

How best of all Fig. 24 can be seen, is at the stopper 48 of the sealing device 21 between the receptacle 5 facing or zuwendbaren sealing surface 33 and the aligned approximately perpendicular to the longitudinal axis 14 and the interior 10 facing further sealing surface, a tapered in the direction of the longitudinal axis 14 bevel 120th arranged. In this case, the bevel 120 may be formed, for example, as part of a conical surface. However, any other forms of space for forming the bevel 120 would also be possible. By this bevel 120, the sealing surface 33, which is preferably formed cylindrical to the longitudinal axis 14, reduced in size or their size, in which case, for example, the sealing surface 33 on the plug 48 in the direction of the longitudinal axis 14, a longitudinal extent or an extent 121 between 1 , 0 mm and 2.5 mm, preferably 1.5 mm. This length in the direction of the longitudinal axis 14 or the extent 121 is to be chosen such that when fully inserted sealing plug 22, the facing sealing surfaces 33, 34 and 116 and the open end 19 ensure sufficient gas tightness and liquid tightness over a predeterminable period of storage and a plant of the same is circumferentially continuous ,

In the Fig. 23 is indicated in dash-dotted lines in the region of the chamfer 120 that instead of this it is possible to form the channel or channels 117 by at least one groove-shaped recess 122 arranged in the region of the sealing surface 33 of the plug 48. It is also possible for a plurality of groove-shaped recesses 122 distributed over the circumference of the plug 48 or sealing surface 33 to be provided. This depression 122 extends or extends from an edge region 123 facing the interior 10 of the receptacle 5 in the direction of the projection 32 and ends or ends at a distance 124 in front of the projection 32. The distance 124 can also be between 1 , 0 mm and 2.5 mm, preferably 1.5 mm, while the extent of 121 correspond. Thus, in turn, the sealing surface 33 passing over the circumference is formed on the stopper 48.

Thus, again with a slight unscrewing of the cap 20 from the receptacle 5 with still engaged threads 42, 43 of the thread assembly 40, a withdrawal of the plug 48 from the receptacle 5 done so far that on the one or more channels 117 in turn a flow connection between the interior 10 of the receptacle 5 and the external atmospheric environment is made.

Furthermore, it is also possible that between the projection 32, in particular its radially outer circumferential surface, and the inner surface 41 of the cap skirt 23 additional locking means are arranged for mutual rotation, so as always to ensure a common relative displacement of the closure device 9 relative to the receptacle 5 as this simplifies in the Fig. 24 is indicated. These latching means can be formed by mutual toothing, cooperating projections and recesses or else by larger surface roughnesses, which can be combined with an additional radial bias of the projection 32 within the receiving area in the cap jacket 23.

Finally, it should be added that these previously described embodiments of the receiving device 1 are blood sampling tubes, the interior 10 after closing with the closure device 9 has a relation to the local atmospheric pressure lower pressure, that is evacuated. For certain applications, it may also be advantageous if the interior 10 is filled only sterile, or in this one for the treatment of the material to be filled stocked active ingredient, and this is not evacuated. But it can also be filled in the evacuated interior 10 only or the active ingredients.

The embodiments show possible embodiments of the receiving device 1, wherein it should be noted at this point that the invention is not limited to the specifically illustrated embodiments thereof, but also various combinations of the individual embodiments are possible with each other and this possibility of variation due to the teaching of technical action representational invention in the skill of those skilled in this technical field. There are therefore also all possible embodiments, which are possible by combinations of individual details of the illustrated and described embodiment, the scope of protection.

For the sake of order, it should finally be pointed out that, for better understanding of the construction of the receiving device 1, these or their components, such as the closure device 9 and the receiving container 5, have been shown partially unevenly and / or enlarged and / or reduced in size.

The task underlying the independent inventive solutions can be taken from the description.

Above all, the individual in the Fig. 1 . 2 ; 3, 4 . 5 ; 6, 7 . 8, 9 ; 10 ; 11 . 12 . 13 . 14 . 15, 16 ; 17; 18 ; 19; 20 ; 21 ; 22 ; 23 . 24 shown embodiments form the subject of independent solutions according to the invention and are combined with each other as desired. The relevant objects and solutions according to the invention can be found in the detailed descriptions of these figures.

REFERENCE NUMBERS

1

recording device

2

mixture

3

medium

4

medium

5

receptacle

36

opening

37

coupling device

38

end

39

end

40

thread arrangement

6

The End

7

The End

8th

bulkhead

9

closure device

10

inner space

41

palm

42

thread

43

thread

44

holder

45

support surface

11

container wall

12

Wall thickness

13

dimension

14

longitudinal axis

15

level

46

mounter

47

thrust bearing

48

Plug

49

level

50

lead angle

16

level

17

dimension

18

surface

19

front

20

cap

51

thread start

52

thread start

53

thread start

54

thread start

55

thread start

21

sealing device

22

sealing plug

23

cap casing

24

coupling part

25

coupling part

56

thread start

57

threaded end

58

threaded end

59

threaded end

60

lead angle

26

coupling part

27

coupling part

28

coupling device

29

extension

30

extension

61

angle

62

thread height

63

thread run

64

thread run

65

Transition radius

31

retaining ring

32

approach

33

sealing surface

34

sealing surface

35

deepening

66

base width

67

radius

68

peak width

69

Transition surface

70

angle

71

radius

72

apex surface

73

admission

74

Retaining plate

75

positioning

111

supply

112

metering

113

receiving opening

114

mandrel

115

deepening

76

guide opening

77

separating device

78

accommodation space

79

Restraint

80

surface

116

sealing surface

117

channel

118

clear width

119

dimension

120

bevel

81

approach

82

web

83

positioning

84

inner dimension

85

stop surface

121

extent

122

deepening

123

border area

124

distance

86

extension

87

flow-through

88

recess

89

depth

90

footprint

91

boundary surface

92

boundary surface

93

Transition surface

94

Transition surface

95

longitudinal extension

96

boundary surface

97

boundary surface

98

flow cross-section

99

thread segment

100

thread segment

101

deepening

102

enforcement

103

head Start

104

protection element

105

Inner diameter

106

rib

107

holder

108

coating member

109

feeding apparatus

110

container

Claims (21)

Receiving device (1) for blood, body fluids, tissue parts or tissue cultures, comprising A closure device (9) which has at least one cap (20) with a cap jacket (23), two end regions (38, 39) spaced apart in the direction of a longitudinal axis (14) and a sealing device (21) made of a pierceable, highly elastic and self-sealing material, A receptacle (5) which is approximately cylindrical in shape, the receptacle (5) having two ends (6, 7) distanced from one another in the direction of a longitudinal axis (14) and delimiting an inner space (10) and at least one of the two ends (6 , 7) has an open end face (19), A threaded assembly (40) disposed between the cap (20) and the receptacle (5) with cooperating threads (42, 43) having a first portion of the thread assembly (40) secured to an inner surface (41) of the cap skirt (23) and a second part of the thread arrangement (40) is arranged to run on the outer surface (18) of the receptacle (5), and in that a peripheral sealing surface (33) of the sealing device (21) arranged approximately concentrically with the longitudinal axis (14) seals against the inner surface of the receptacle (5) in the section of the open end (6),
characterized in that
in the relative rotational or pivotal movement about the common longitudinal axis (14) the threads (42, 43) of the threaded assembly (40) over the entire length of the Einschraubweges until reaching the fully screwed position engage with each other
and that between the sealing device (21) and the open end (6) of the receptacle (5) with at least engaged threads (42, 43) of the threaded assembly (40) on the receptacle (5) and on the cap (20) at least one Channel (117) is formed. Receiving device (1) according to claim 1, characterized in that the at least one thread (42, 43) seen over its longitudinal course by several in Circumferentially arranged one behind the other and spaced from each other first thread segments (99, 100) is formed. Receiving device (1) according to claim 1 or 2, characterized in that the thread arrangement (40) is designed to be more continuous and that the thread arrangement (40) has three over the inner surface (41) of the cap (20) and three over the outer surface (18). the receiving container (5) arranged distributed threads (42, 43). Receiving device (1) according to one of the preceding claims, characterized in that the-inserted into the cap (20) sealing device (21) before insertion at least in the region of the inner surface of the receptacle (5) facing the sealing surface (33) with a coating is provided. Receiving device (1) according to one of the preceding claims, characterized in that the inner surface (41) of the cap skirt (23) is provided with a coating at least in the region of the thread turn (43). Receiving device (1) according to claim 5, characterized in that the coating and / or a lubricant in at least one recess (101) in the region of the thread (43) is stored. Receiving device (1) according to one of the preceding claims, characterized in that the material for forming the cap (20) is already added or admixed with the lubricant or lubricant additive. Receiving device (1) according to one of the preceding claims, characterized in that the at least one thread (42, 43) of the thread arrangement (40) at least at one with the other thread (42, 43) cooperating portion has a surface roughness between 0.0125 microns and 0.05 μm. Receiving device (1) according to one of the preceding claims, characterized in that the sealing device (21) in the cap (20) via a coupling device (28) is held, wherein the coupling device (28) through in the direction the longitudinal axis (14) spaced from each other and at least partially over the inner circumference, the cap skirt (23) in the direction of the longitudinal axis (14) projecting projections (29, 30) is formed, which a groove-shaped receiving portion on the inside of the cap skirt (23) and that a clear inner width (118) of the open end (6) of a receptacle (5) zuwendbaren extension (30) corresponds approximately to an outer dimension (119) of the receptacle (5) in the region of its open end (6). Receiving device (1) according to one of the preceding claims, characterized in that the sum of the thread lengths of the threaded arrangement (40) forming threads (42) of the receptacle (5) in the plane perpendicular to the longitudinal axis (14) aligned plane (49) over the circumference is equal to or smaller than an outer circumference of the receptacle (5) in the region of the threaded arrangement (40). Receiving device (1) according to one of the preceding claims, characterized in that the thread (42) with its full thread height (62) between its threaded beginning (54 to 56) and its threaded end (57 to 59) seen over the circumference over an angle (61) extends between 50 ° and 80 °. Receiving device (1) according to any one of the preceding claims, characterized in that a threaded cross-section of the thread (42) in a parallel to and through the longitudinal axis (14) extending aligned plane is formed asymmetrically. Receiving device (1) according to one of the preceding claims, characterized in that the threaded cross section in the portion of the full thread height (62) of the thread (42) has a parallel to the longitudinal axis (14) aligned vertex surface (72), wherein the threaded cross-section on the open Front side (19) of the receptacle (5) facing side with a first radius (67) starting from the apex surface (72) towards the outer surface (18) and on the from the open end face (19) of the receptacle (5) side facing away is limited with a starting from the outer surface (18) towards the open end face (19) inclined rectilinear transition surface (69). Receiving device (1) according to claim 13, characterized in that the thread cross section between the parallel to the longitudinal axis (14) aligned vertex surface (72) and the transition surface (69) with a further radius (71) is limited and that the first radius (67) is greater than the other radius (71). Receiving device (1) according to one of the preceding claims, characterized in that the outer surface (18) of the receptacle (5) at least in the region of the thread (42) and / or the receptacle (5) at least in the region of the sealing surface (33). the sealing device (21) facing the inner surface is provided with a coating. Receiving device (1) according to one of the preceding claims, characterized in that a relative to the outer atmosphere closed interior (10) is lowered to a lower pressure relative to the outer ambient pressure, in particular evacuated. Receiving device (1) according to one of the preceding claims, characterized in that the channel (117) between a in the interior (10) to be inserted plug (48) of the sealing device (21) and the open end (6) of the receptacle (5) is. Receiving device (1) according to one of the preceding claims, characterized in that the stopper (48) of the sealing device (21) between a receiving container (5) facing the sealing surface (33) and an approximately perpendicular to a longitudinal axis (14) aligned and the Interior (10) facing, further sealing surface in the direction of the longitudinal axis (14) tapered chamfer (120) is arranged. Receiving device (1) according to one of the preceding claims, characterized in that the sealing surface (33) on the plug (48) in the direction of the longitudinal axis (14) has a dimension (121) between 1.0 mm and 2.5 mm, preferably 1, 5 mm. Receiving device (1) according to one of claims 1 to 16, characterized that the channel (117) by at least one arranged in the region of the sealing surface (33) of the plug (48) groove-shaped recess (122) is formed. Receiving device (1) according to claim 20, characterized in that the recess (122), starting from a the interior (10) of the receptacle (5) facing the edge region (123) towards the projection (32) extends and at a distance (124) between 1.0 mm and 2.5 mm, preferably 1.5 mm, before ends.

Images