EP1804865B1 - Dial-down mechanism for wind-up pen - Google Patents

Dial-down mechanism for wind-up pen Download PDF

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Publication number
EP1804865B1
EP1804865B1 EP05807260A EP05807260A EP1804865B1 EP 1804865 B1 EP1804865 B1 EP 1804865B1 EP 05807260 A EP05807260 A EP 05807260A EP 05807260 A EP05807260 A EP 05807260A EP 1804865 B1 EP1804865 B1 EP 1804865B1
Authority
EP
European Patent Office
Prior art keywords
dial
cam
key
down mechanism
injection device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP05807260A
Other languages
German (de)
French (fr)
Other versions
EP1804865A1 (en
Inventor
Claus Schmidt MØLLER
Christian Peter Enggaard
Bo Radmer
Tom Hede Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
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Publication date
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Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to PL05807260T priority Critical patent/PL1804865T3/en
Priority to EP05807260A priority patent/EP1804865B1/en
Publication of EP1804865A1 publication Critical patent/EP1804865A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • the dial-down mechanism may further comprise a first and a second dial-down cam, and a first and a second dial-down key.
  • the first dial-down key may be adapted to engage and cooperate with the first dial-down cam, whereas the second dial-down key may be adapted to engage and cooperate with the second dial-down cam.
  • Fig. 3 shows another radial embodiment according to the present invention.
  • the movement of the arm 26 is controlled by a track 23 in the nut 27.
  • the track 23 is engaged by the track/cam follower 24 which precisely guides the dial-down key 28 from one tooth to the neighboring tooth during dial-down.
  • the opening 25 in the center of the nut 27 is provided with a track follower 29.
  • This track follower is adapted to engage with a track in the outer surface of a piston rod (not shown).
  • a dose is set by rotating the dose setting member 30 and the nut 32 whereby the torsion spring 35 is strained.
  • the dose setting member 30 is prevented from returning to its initial position due the toothing mechanism 37 positioned between the nut 32 and the drive member 33.
  • the dose setting member 30 is simply rotated in the opposite direction. The interaction between ratchet 38 and nut 32 during dial-down is described in connection with Fig. 2 .

Abstract

The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising dial-up cam arranged to receive and engage with a dial-up key, wherein the dial-up cam and the dial-up key are adapted to, upon rotation of a dose setting member in a first direction, cooperate to strain the torsion spring of the injection device, and a dial-down cam arranged to receive and engage with a dial-down key, wherein the dial-down cam and the dial-down key are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring of the injection device, the second rotation direction being opposite to the first rotation direction.

Description

    FIELD OF THE INVENTION
  • The present invention relates to a dial-down mechanism for automatic wind-up pens. In particular, the present invention relates to integrated axial and radial dial-down mechanisms for wind-up pens.
    • BACKGROUND OF THE INVENTION
  • In known injection devices, such as wind-up pens, based on torsion springs, the use of dial down mechanisms rely on that the user of the injection device applies a force to a rotatable dose setting member of the injection device. The force must be applied in order to axially withdraw the dose setting member a certain distance to release the dose setting member from a toothing mechanism or ratchet positioned within the body of the injection device. By releasing the dose setting member from this toothing mechanism the dose setting member can be reversed by rotation and set at a new and lower dose.
  • An example of a known wind-up pen applying a torsion spring may for example be found in US 5,104,380 . However, the pen suggested in US 5,104,380 does not offer a dial-down mechanism. A dial-down mechanism is provided in WO 02/053214 . However, the proposed solution in WO 02/053214 involves a linear spring.
  • It is a disadvantage of known torsion spring-based dial-down systems that the user must apply a force to withdraw the dose setting member a certain axial distance and, at the same time, adjust the angular position of the dose setting member. Especially for persons having reduced motoric skills or reduced finger strength, such as children, elderly people or disabled people this is a rather complicated procedure.
  • US 2004/199117 discloses a medication delivery pen including an arrangement where incorrect dosage settings may be corrected by a user via a dial-back feature that enables the user to reset the dose amount without expelling medication and without having to dial a dose knob to an extended, reset position. The medication delivery pen of US 2004/199117 is a so-called manual pen where the injection of a medicament from the pen is driven by a force purely provided by the user of the pen. Thus, the Injection of a medicament is not assisted by any resilient member, such as a spring, and the dial-down arrangement disclosed in US 2004/199117 is not arranged to maintain a resilient member in a given strained position.
  • It is an object of the present invention to provide a dial-down mechanism for automatic wind-up pens. Automatic wind-up pens are here to be understood as pens having a resilient member, such as a spring, to assist injecti ng a medicament from an injection device.
    • SUMMARY OF THE INVENTION
  • The above-mentioned object is complied with by providing, in a first aspect, a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising
    • dial-up cam arranged to receive and engage with a dial-up key, wherein the dial-up cam and the dial-up key are adapted to, upon rotation of a dose setting member in a first direction, cooperate to strain the torsion spring of the injection device, and
    • a dial-down cam arranged to receive and engage with a dial-down key, wherein the dial-down cam and the dial-down key are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring of the injection device, the second rotation direction being opposite to the first rotation direction.
  • Generally speaking the dial-down mechan ism may be implemented as a radial dial-down mechanism or as an axial dial-down mechanism. In the radial dial-down mechanism the dial-down key or keys are arranged to move in the radial direction of the mechanism. This may also be the radial direction of the injection device. In the axial dial-down mechanism, the dial-down key or keys are arranged to move in the axial direction of the injection device.
  • Also it should be noted that the dial-up key or keys, and the dial-down key or keys may be different keys - i.e. physically separated keys. However, it may also be that the dial-up and dial-down key is constituted by the same key. Thus, it may be that the mechanism accord ing to the present invention comprises only a single key which is used for both dial-up and dial down.
  • The dial-up and dial-down cams may be arranged as openings or indentations in an outer surface part of a disc-shaped cam member. The cam member may, alternatively, also be shaped as a substantially cylindrical mem ber. In particular, the dial-up and dial-down cams may be arranged in a substantially plane surface part of the cam member. This substantially plane surface part may be substantially perpendicular to an axial direction of the disc or cylindrical shaped cam member. The cam member may be a hollow construction, or alternatively, the cam member may be a solid construction.
  • In both the radial and the axial mechanism, the dial-up ca m may form a curved track, such as part of a circular, elliptical or parabolic track. The dial-down cam may form part of a V-shaped track, or alternative, it may have a rectangular shape.
  • The dial-down mechanism may comprise a first and a second dial-up cam. Furthermore, the dial-down mechanism may comprise a first and a second dial-up key, wherein the first dial-up key may be adapted to engage and cooperate with the first dial-up cam, and wherein the second dial-up key may be adapted to engage and cooperate with the second dial-up cam.
  • The dial-down mechanism may further comprise a first and a second dial-down cam, and a first and a second dial-down key. The first dial-down key may be adapted to engage and cooperate with the first dial-down cam, whereas the second dial-down key may be adapted to engage and cooperate with the second dial-down cam.
  • It may also be that the dial-up and dial-down cams form part of regions of the same track. Furthermore, the dial-up and dial-down keys may be constituted by the same key, said key being adapted to engage and cooperate with dial-up and dial-down cams of the same track.
  • In the axial mechanism, the dial-up and dial-down cams may be arranged as cams having an axial component parallel to an axial direction of the injection device. The dial-up and dial-down cams may be arranged on an outer and curved surface part of a substantially cylindrical cam member. This substantially cylindrical cam member may be the dose setting member of the injection device, or it may be a separate component cooperating with the dose setting member of the injection device.
  • In the axial mechanism, the dial-up cam may be substantially parallel to an axial direction of the injection device. In order to be able to release an associated ratchet from a toothing the dial-down cam may form an angle, such as around 45 degrees, to the dial-up cam.
  • In a third aspect, the present invention relates to a medication delivery device, such as a handheld medication delivery device, comprising a dial-down mechanism according to the first aspect of the present invention.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • The present invention will now be described in further details with reference to th e accompanying figures, wherein
    • Fig. 1 shows the principle of a radial dial-up and dial-down mechanism where the keys on the flexible arm are used for both dial-up and dial-down,
    • Fig. 2 shows a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down,
    • Fig. 3 shows a radial dial-up/dial down mechanism with separate keys for dial-up and dial-down where the movements of the dial-down key is determined by a track in the nut,
    • Fig. 4 shows a n injection device having an integrated radial dial-down mechanism, and
    • Fig. 5 shows a n injection device having an integrated axial dial-down mechanism.
  • While the invention is susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, a nd alternatives falling within the scope of the invention as defined by the appended claims.
    • DETAILED DESCRIPTION OF THE INVENTION
  • The dial-down mechanism according to the present invention may be implemented as an axial or a radial mechanism. Both of these mechanisms may be integrated into an injection device, such as an injection pen.
  • A radial solution is shown in Fig. 1. Fig. 1a shows a rotatable inner part 2 biased against a fixed outer part 1. The biasing force is provided by a torsion spring (not shown) in the counter-clockwise direction. The inner part 2, which is rotatable around a center axis 6, has one or more flexible arms 3 adapted to engage with the edges 5 in the fixed outer part 1. Fig. 1b shows the arrangement of Fig. 1a with a rotatable disc 7 (hatched region) placed on top of the inner part 2 and outer part 1. The disc 7 has an opening 8. The edges defining the opening 8 constitute dial-up and dial-down cams. A pick-up key 4 attached to, or integrated with, the flexible arm 3 operates as a cam follower when the disc 7 is rotated relative to the outer part 1.
  • The system illustrated in Fig. 1 is operated in the following manner:
  • When a dose is to be set (dial-up), the inner part 2 is rotated in the clockwise direction whereby the flexible arm 3 will move from one edge 5 to the neighboring edge or edges - depending on the angle of rotation. The inner part 2 is driven by disc 7 - thus, when disc 7 is rotated the inner part 2 rotates with it. During rotation in the clockwise direction, the pick-up key 4 moves in and out along the radial direction.
  • When the disc 7 is rotated in the counter clockwise direction (dial-down direction) the pick-up key 4, and thereby the flexible arm 3, is lifted out of its engaging position with the edge 5 of the outer part 1. When the arm 3 is fully disengaged from the edge 5 the inner part 2 may be rotated in the counter clockwise direction relative to the outer part 1. It is a characteristic of the system shown in Fig. 1 that the pick-up key 4 is used for both dial-up (increasing a dose) and dial-down (resetting or reducing a dose).
  • It should be noted that the directions of rotation could be reversed so that dial-up is achieved by rotating the inner portion 2 in the counter clockwise direction. In such a configuration dial-down could be achieved by rotating disc 7 in the clockwise direction.
  • Fig. 2 shows an exploded drawing of the radial embodiment of the dial-down mechanism according to the present invention. The main difference compared to the embodiment shown in Fig. 1 is that the embodiment of Fig. 2 applies different pick-up keys for dial-up (pick-up key 11) and dial-down (pick-up key 12). The dial-up key 11 engages with track 15 of the disc 14, whereas dial-down key 12 engages with track 16 of the disc 14. Tracks 15 and 16 are formed as through-going openings or indentations in a planar surface of the disc 14. The dial-up tracks 15 take the form of curved tracks whereas the dial-down tracks 16 are V-shaped. An obvious alternative to the V-shape is a rectangular shape. It should be noted that the general idea is that the dial-up tracks 15 should be capable of transferring a momentum to a torsion spring 18. In the same manner, the dial-down tracks 16 should be capable of releasing the dial-down keys (and thereby release energy) in case the disc 14 is rotated just a few degrees relative to the nut 10.
  • The dial-down keys 12 are integrated with the flexible arms 19. These arms are fabricated of a resilient material such as for example plastic. The flexible arms 19 with integrated dial-down keys 12 form an integral part of the ratchet 13. Thus, the ratchet including arms and dial-down keys may preferably be fabricated of the same material, such as of plastic. In order to bias the dial-down keys 12 against the teeth 20 of the nut 10 a torsion spring 18 is arranged coaxially with the ratchet 13. An opening 21 is provided in the center part of the nut 10. The side wall of this opening is provided with threads 22 which are adapted to engage with a threaded outer surface of a piston rod (not shown).
  • Fig. 3 shows another radial embodiment according to the present invention. In this embodiment, the movement of the arm 26 is controlled by a track 23 in the nut 27. The track 23 is engaged by the track/cam follower 24 which precisely guides the dial-down key 28 from one tooth to the neighboring tooth during dial-down. In contrast to Fig. 2 the opening 25 in the center of the nut 27 is provided with a track follower 29. This track follower is adapted to engage with a track in the outer surface of a piston rod (not shown).
  • Fig. 4 shows an injection device having a radial dial-down mechanism according to the present invention. Among other components the injection device shown in Fig. 4 shows a dose setting member 30, a piston rod 31 having a threaded outer surface and a drive track arranged in the axial direction of the piston rod, a nut 32, a torsion spring 35, a drive member 33, the threaded portion 34 of the housing, a lease mechanism 36, a toothing mechanism 37, and ratchet 38.
  • A dose is set by rotating the dose setting member 30 and the nut 32 whereby the torsion spring 35 is strained. The dose setting member 30 is prevented from returning to its initial position due the toothing mechanism 37 positioned between the nut 32 and the drive member 33. In case the user wants to reduce a preset dose, the dose setting member 30 is simply rotated in the opposite direction. The interaction between ratchet 38 and nut 32 during dial-down is described in connection with Fig. 2.
  • Fig. 5 shows an injection device having an axial dial-down mechanism according to the present invention. Among other components the injection device shown in Fig. 5 comprising a dose setting member 40, an opening 41 defining dial-up and dial-down cam surfaces, a cam follower 42, a torsion spring 43, a ratchet 44, and a piston rod 45. The general idea behind the axial dial-down mechanism is to use the torsion spring 43 to both drive and rotate the piston rod 45 and to ensure that the upper and lower parts of the toothing 48 re main together.
  • When a dose is to be set, the cam follower 42 engages with cam surface 46. As a result the torsion spring 43 is strained because the ratchet 44 is prevented from reversing due to the toothing 48. During dial-up the ratchet 44 will move up and down along cam surface 46 as the upper and lower parts of the toothing 48 rotate relative to each other. In case of dial-down the cam surface 47 will lift and thereby release the upper part of the toothing from the lower part of the toothing thereby the ratchet 44 is allowed to rotate an angle corresponding to one tooth.

Claims (10)

  1. A dial-down mechanism for an injection device comprising a torsion spring (18) for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising
    - dial-up cam (15) arranged to receive and engage with a dial-up key (11), wherein the dial-up cam (15) and the dial-up key (11) are adapted to, upon rotation of a dose setting member (x) in a first direction, cooperate to strain the torsion spring (18) of the injection device, and
    - a dial-down cam (16) arranged to receive and engage with a dial-down key (12), wherein the dial-down cam (16) and the dial-down key (12) are adapted to, upon rotation of the dose setting member in a second direction, cooperate to release the torsion spring (18) of the injection device, the second rotation direction being opposite to the first rotation direction.
  2. A dial-down mechanism according to claim 1, wherein the dial-up cam (15) forms a curved track.
  3. A dial-down mechanism according to claim 2, wherein the curved dial-up cam (15) forms part of a circular, elliptical or parabolic track.
  4. A dial-down mechanism according to any of claims 1-3 comprising a first and a second dial-up cam.
  5. A dial-down mechanism according to claim 4 comprising a first and a second dial-up key, wherein the first dial-up key is adapted to engage and cooperate with the first dial-up cam, and wherein the second dial-up key is adapted to engage and cooperate with the second dial-up cam.
  6. A dial-down mechanism according any of the preceding claims, wherein the dial-down cam (16) forms a V-shaped track.
  7. A dial-down mechanism according to any of the preceding claims comprising a first and a second dial-down cam.
  8. A dial-down mechanism according to claim 7 comprising a first and a second dial-down key, wherein the first dial-down key is adapted to engage and cooperate with the first dial-down cam, and wherein the second dial-down key is adapted to engage and cooperate with the second dial-down cam.
  9. A dial-down mechanism according any of the preceding claims, wherein the dial-up and dial-down cams form part of regions of the same track.
  10. A medication delivery device comprising a dial-down mechanism according to any of claims 1- 9.
EP05807260A 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen Active EP1804865B1 (en)

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PL05807260T PL1804865T3 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
EP05807260A EP1804865B1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen

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EP04077900 2004-10-21
PCT/EP2005/011285 WO2006045526A1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen
EP05807260A EP1804865B1 (en) 2004-10-21 2005-10-20 Dial-down mechanism for wind-up pen

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EP1804865A1 EP1804865A1 (en) 2007-07-11
EP1804865B1 true EP1804865B1 (en) 2009-09-30

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Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
RU2388498C2 (en) 2004-10-21 2010-05-10 Ново Нордиск А/С Device for injections furnished with torsional spring and rotary indicator
ATE444090T1 (en) 2004-10-21 2009-10-15 Novo Nordisk As SELECTION MECHANISM FOR A ROTARY PIN
PL208660B1 (en) * 2005-05-25 2011-05-31 Kappa Medilab Społka Z Ograniczoną Odpowiedzialnością Automatic applicator, particularly for application of the insulin
ATE499962T1 (en) 2005-07-27 2011-03-15 Novo Nordisk As DOSE MECHANISM FOR AN INJECTION DEVICE FOR LIMITING A DOSE SETTING ACCORDING TO THE REMAINING AMOUNT OF DRUG
CN101227942B (en) † 2005-07-27 2010-10-20 诺沃-诺迪斯克有限公司 Syringe device with a dose limiting mechanism and an additional safety mechanism
DE102005060929A1 (en) * 2005-09-14 2007-03-15 Tecpharma Licensing Ag Product e.g. insulin, injecting device, has housing and operating knob with locking units that are formed such that movement of operating knob in one direction has smaller resistance in contrast to movement in other direction
GB0524604D0 (en) * 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
JP5253387B2 (en) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー／エス Injection device with mode locking means
EP2029199B1 (en) * 2006-05-29 2015-07-08 Novo Nordisk A/S Mechanism for injection device
EP2249905B1 (en) * 2008-02-07 2011-10-19 Novo Nordisk A/S Injection device having mode defining elements
CN102196835B (en) * 2008-10-24 2014-08-27 诺沃—诺迪斯克有限公司 Dial-down mechanism for wind-up pen
GB2465390A (en) 2008-11-17 2010-05-19 Owen Mumford Ltd Syringe needle cover remover
EP2266647A1 (en) * 2009-06-25 2010-12-29 Sanofi-Aventis Deutschland GmbH Drive mechanism for drug delivery device
EP2470245B1 (en) * 2009-08-24 2018-05-16 SHL Group AB Dose reset mechanism
PL215310B1 (en) * 2009-10-30 2013-11-29 Kappa Medilab Spolka Z Ograniczona Odpowiedzialnoscia Automatic applicator, especially for insulin
EP2329857A1 (en) * 2009-12-03 2011-06-08 Sanofi-Aventis Deutschland GmbH A drug delivery device
GB0921295D0 (en) 2009-12-04 2010-01-20 Owen Mumford Ltd Injection appaeratus
JP5795775B2 (en) 2010-02-17 2015-10-14 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Injection device
WO2011101376A1 (en) * 2010-02-18 2011-08-25 Sanofi-Aventis Deutschland Gmbh Clutch mechanism
WO2011114343A1 (en) * 2010-03-19 2011-09-22 Pawan Trilokchand Agrawal Multi dose parental drug delivery system with exchangeable glass cartridge
NZ629637A (en) 2010-05-27 2015-12-24 J&J Solutions Inc Closed fluid transfer system
GB201018827D0 (en) * 2010-11-08 2010-12-22 Owen Mumford Ltd Injection device
US9072839B2 (en) * 2010-11-29 2015-07-07 Sanofi-Aventis Deutschland Gmbh Automatic delivery device with triggering mechanism
USD729930S1 (en) 2011-03-08 2015-05-19 Novo Nordisk A/S Injection device
US9421334B2 (en) * 2011-03-16 2016-08-23 Becton, Dickinson And Company Multiple use disposable injection pen
WO2012129120A1 (en) * 2011-03-18 2012-09-27 Becton Dickinson And Company End of injection indicator for injection pen
AR085486A1 (en) * 2011-03-25 2013-10-02 Sanofi Aventis Deutschland MECHANISM OF DOSE ESTABLISHMENT AND INJECTION DEVICE
EP2707063B1 (en) * 2011-05-12 2019-06-26 SHL Medical AG Medical delivery device with dose re-setting
USD734450S1 (en) 2011-11-01 2015-07-14 Novo Nordisk A/S Injection device
US9533106B2 (en) * 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
PL220720B1 (en) * 2012-02-08 2015-12-31 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Injection device with a reset mechanism of the dose
RU2608908C2 (en) * 2012-03-15 2017-01-26 Бектон, Дикинсон Энд Компани Disposable syringe-pen for several doses
GB2501897B (en) * 2012-05-09 2014-09-03 Owen Mumford Ltd Injection devices
CH706567A2 (en) * 2012-05-16 2013-11-29 Tecpharma Licensing Ag Improved device to set a dose a limiting mechanism for an apparatus for administering a product.
MX2014013842A (en) 2012-05-31 2015-02-18 Novo Nordisk As Dial-down mechanism for wind-up pen.
EP2692379B1 (en) * 2012-08-01 2014-07-16 TecPharma Licensing AG Injection device with a coupling
CN104955505B (en) * 2013-02-01 2018-01-30 诺和诺德股份有限公司 Non axial work inclusion emptying mechanism and the injection device for including the non axial work inclusion emptying mechanism
DE202013001350U1 (en) * 2013-02-08 2014-05-09 Haselmeier Gmbh injection device
CN105102037A (en) * 2013-04-10 2015-11-25 赛诺菲 Drive mechanism of a drug delivery device
TW201509468A (en) * 2013-04-10 2015-03-16 Sanofi Sa Injection device
JP6448623B2 (en) * 2013-05-27 2019-01-09 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Assembly for a drug delivery device and drug delivery device
EP3007747B1 (en) * 2013-06-14 2017-05-10 Novo Nordisk A/S Drug delivery device with dual layer spring
KR102375565B1 (en) * 2013-09-23 2022-03-17 사노피-아벤티스 도이칠란트 게엠베하 Assembly for a drug delivery device and drug delivery device
EP3057634A1 (en) * 2013-10-16 2016-08-24 Novo Nordisk A/S Drug delivery device with improved dose reset mechanism
JP6577942B2 (en) * 2013-10-18 2019-09-18 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Injection device
RU2674085C1 (en) * 2013-11-22 2018-12-04 Санофи-Авентис Дойчланд Гмбх Spring assisted drug delivery mechanism
KR20160088317A (en) * 2013-11-22 2016-07-25 사노피-아벤티스 도이칠란트 게엠베하 Spring assisted drug delivery device
CN105764545B (en) * 2013-11-22 2019-12-10 赛诺菲-安万特德国有限公司 Spring assisted drug delivery device
AR098642A1 (en) 2013-12-09 2016-06-01 Sanofi Aventis Deutschland DRIVE AND MECHANISM ELEMENT FOR A DRUG SUPPLY DEVICE AND DRUG SUPPLY DEVICE
DE202014001135U1 (en) * 2014-02-05 2015-05-06 Haselmeier Gmbh injection device
ES2731642T3 (en) * 2014-02-20 2019-11-18 Medirio Sa Rotor for medical flow regulation devices
WO2016036600A1 (en) * 2014-09-05 2016-03-10 Min Wei Automatic injection device with variable dosing
WO2016055505A1 (en) 2014-10-08 2016-04-14 Novo Nordisk A/S A torsion spring for an injection device and an injection device comprising such torsion spring
US10576212B2 (en) * 2014-12-08 2020-03-03 Sanofi Dose setting mechanism and drug delivery device herewith
DE102014225687B3 (en) * 2014-12-12 2016-01-21 Vetter Pharma-Fertigung GmbH & Co. KG injection device
WO2016135237A1 (en) 2015-02-27 2016-09-01 Novo Nordisk A/S Drug delivery device with dose reset mechanism
US10441722B2 (en) 2015-04-29 2019-10-15 Novo Nordisk A/S Drug delivery device with spring mechanism
WO2017055492A1 (en) * 2015-10-01 2017-04-06 Novo Nordisk A/S Torsion spring fixation in automatic drug delivery device
JP6893507B2 (en) 2015-10-09 2021-06-23 ノボ・ノルデイスク・エー／エス Drug delivery device with a slender drive mechanism
PL414383A1 (en) 2015-10-15 2017-04-24 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Setting mechanism, in particular for dosing pharmaceuticals
PL414382A1 (en) 2015-10-15 2017-04-24 Copernicus Spółka Z Ograniczoną Odpowiedzialnością Setting mechanism, in particular for dosing
PL227678B1 (en) 2015-12-22 2018-01-31 Copernicus Spolka Z Ograniczona Odpowiedzialnoscia Control and drive system for the device intended for injection and the device for making injections equipped with such a system
EP3429665A1 (en) * 2016-03-15 2019-01-23 Sanofi Dosing mechanism for multi-shot injection device comprising flexible ratchet element
PL3108914T3 (en) 2016-07-07 2019-08-30 Copernicus Sp. Z O.O. Injection device for delivering a defined number of equal doses of a liquid substance
WO2018041899A1 (en) 2016-08-31 2018-03-08 Novo Nordisk A/S Drug delivery device with over-torque protection mechanism
GB201615439D0 (en) 2016-09-12 2016-10-26 Norton Healthcare Ltd Dose setting mechanism
GB201615442D0 (en) 2016-09-12 2016-10-26 Norton Healthcare Ltd Dose setting mechanism
EP3515408A1 (en) 2016-09-23 2019-07-31 Delpor, Inc. Stable compositions for incretin mimetic compounds
RU2653688C1 (en) * 2017-01-19 2018-05-11 Бектон, Дикинсон Энд Компани Disposable syringe-pen for several doses
CN110869076A (en) 2017-06-27 2020-03-06 诺和诺德股份有限公司 Torsion spring driven injection device
US10688247B2 (en) * 2017-07-13 2020-06-23 Haselmeier Ag Injection device with flexible dose selection
PL232651B1 (en) 2017-07-18 2019-07-31 Copernicus Spolka Z Ograniczona Odpowiedzialnoscia Coupling with locking system for the medical injecting device
US10265471B2 (en) 2017-08-30 2019-04-23 Pirouette Medical LLC Compact auto-injector
US10441714B2 (en) 2017-10-05 2019-10-15 Pirouette Medical LLC Protective case for an auto-injector
AU2019283460A1 (en) * 2018-06-06 2020-11-19 Datamars Limited Improvements in, or relating to, applicators
USD926973S1 (en) 2019-09-05 2021-08-03 Novo Nordisk A/S Injection device

Family Cites Families (425)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
GB574705A (en) 1940-04-26 1946-01-17 Boulton Aircraft Ltd Improvements in and relating to machine guns
US2392196A (en) 1945-02-24 1946-01-01 Arthur E Smith Syringe
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3556099A (en) 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
CH563690A5 (en) 1973-03-09 1975-06-30 Radioelectrique Comp Ind
US3880162A (en) 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
DE2812729A1 (en) 1978-03-23 1979-09-27 Michael Becker INJECTION DEVICE FOR INTRAMUSCULAR INJECTION, PRESENTLY OF INSULIN
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4430079A (en) 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
WO1980001643A1 (en) 1979-02-12 1980-08-21 American Hospital Supply Corp Capacitive switching circuit for energizing remote controlled device
DE2906830C2 (en) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen Device for continuous infusions
NL7901750A (en) 1979-03-06 1980-09-09 Stamicarbon DEVICE FOR MIXING TWO FLUIDA.
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
USRE31315E (en) 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
JPS5733A (en) 1980-05-28 1982-01-05 Sanyo Electric Co Charger for battery
US4368731A (en) 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
JPS56163486A (en) 1980-05-21 1981-12-16 Citizen Watch Co Ltd Electronic timepiece
DE3048135A1 (en) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Intravenous liquid administration by pump - with external pressure sensing cartridge regulating discharge pressure
IT1168101B (en) 1981-01-15 1987-05-20 Domenico Colombo PERFECTED MANUAL PRESSURE SYRINGE, FOR DENTAL USE
IE52621B1 (en) 1981-02-12 1988-01-06 Turner Robert Charles Dose metering plunger devices for use with syringes
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
AR228395A1 (en) 1981-05-07 1983-02-28 Merck & Co Inc SYRINGE TO REGULATE THE AMOUNT SUPPLIED OF A PLASTIC SUBSTANCE
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
DE3204178C2 (en) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipetting device
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (en) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Security paper
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
JPS5997672A (en) 1982-11-29 1984-06-05 テルモ株式会社 Syringe injection apparatus
US4493704A (en) 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
EP0143895B1 (en) 1983-09-07 1987-12-23 Disetronic Ag Portable infusion apparatus
US4648872A (en) 1983-11-15 1987-03-10 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4584439A (en) 1983-12-01 1986-04-22 Floating Membranes, Inc. Audio transducer with controlled flexibility diaphragm
ES277095Y (en) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. SUPPLIER-DISPENSER OF INJECTABLE PRODUCTS
US4676122A (en) 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4812724A (en) 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (en) 1985-06-14 1986-12-19 Hazon Bernard Device for step-by-step advance of syringe plungers by means of a double coaxial screw with control of the injection rate. Application to repetitive intradermic medicinal injections
AU6541986A (en) 1985-11-08 1987-06-02 Disetronic A.G. Injection instrument
DE3609555A1 (en) 1986-03-21 1987-09-24 Josef Porner Blood-collecting syringe
DE3638984C3 (en) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injection device
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
NL8701091A (en) 1987-05-08 1988-12-01 Spruyt Hillen Bv INJECTION PEN.
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
GB8720477D0 (en) 1987-08-29 1987-10-07 Bick P A Resynchronisation of body clock
JPH01100495A (en) 1987-10-13 1989-04-18 Seiko Epson Corp Stop watch
FR2622457A1 (en) 1987-11-03 1989-05-05 Piccinali Eric Mesotherapeutic injector with microprocessor
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
CH675078A5 (en) 1988-01-22 1990-08-31 Nosta Ag
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
DE8801613U1 (en) 1988-02-09 1988-04-21 Wegu Gummi- Und Kunststoffwerke Walter Draebing Kg, 3500 Kassel, De
DK166948B1 (en) 1988-02-10 1993-08-09 Dcp Af 1988 As DOSING UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A FLUID, SUCH AS INSULIN, FROM A GLASS STUBLE
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
JP2717808B2 (en) 1988-08-10 1998-02-25 テルモ株式会社 Syringe pump
DE3833821A1 (en) 1988-10-05 1990-04-12 Braun Melsungen Ag INJECTION DEVICE
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
JPH02126184A (en) 1988-11-04 1990-05-15 Casio Comput Co Ltd Stop watch device
JPH02182267A (en) 1989-01-06 1990-07-16 Oriental Kiden Kk Drip monitor apparatus
FR2642786B1 (en) 1989-02-07 1991-05-10 Europ Agence Spatiale LINEAR OR CIRCULAR LOCKING DEVICE, OF THE SAID RATCHET TYPE, SELF-LOCKING AND WITH AUTOMATIC RELEASE
DK68789A (en) 1989-02-14 1990-08-15 Novo Nordisk As injector
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
DE3908892A1 (en) 1989-03-17 1990-09-20 Siemens Ag CIRCUIT ARRANGEMENT AND DEVICE FOR CONTACTLESS SETPOINT SETTING FOR AN INTEGRATED CIRCUIT COVERED WITH NON-MAGNETIC MATERIAL
US4924737A (en) 1989-03-20 1990-05-15 Gummow Tool Company Positive drive ratchet
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
DE3923079A1 (en) 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid
US5011479A (en) 1989-10-06 1991-04-30 Son Le Cover and connector for hypodermic needle
DE3933542A1 (en) 1989-10-07 1991-04-18 Kg Catts Ges Fuer Erkennungs & CODE ARRANGEMENT AND DEVICES FOR READING AND CODING THE SAME
US5002537A (en) 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US4990142A (en) 1989-10-23 1991-02-05 Gte Products Corporation Hypodermic syringe
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
DE4001238A1 (en) 1990-01-18 1991-07-25 Basf Ag METHOD FOR ENRICHMENT OR CLEANING OF BIOMOLECULES
DK17890A (en) 1990-01-22 1991-07-23 Novo Nordisk As METHOD AND APPARATUS FOR MIXTURE AND INJECTION OF A MEDICINE
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
US4998922A (en) 1990-02-23 1991-03-12 Kuracina Thomas C Safety syringe cap minimizing needle-stick probability
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5104388A (en) 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
EP0485345B1 (en) 1990-10-19 1998-03-04 Patrizio Compagnucci A single-use syringe incorporating a sliding protection cap for the needle
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
JPH04256757A (en) 1991-02-07 1992-09-11 Terumo Corp Quantitative dispenser
DE69203472T2 (en) 1991-02-07 1996-01-04 Terumo Corp Dosing device for injector.
US5176646A (en) 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
DE4112259A1 (en) 1991-04-15 1992-10-22 Medico Dev Investment Co INJECTION DEVICE
DK68991D0 (en) 1991-04-17 1991-04-17 Novo Nordisk As HEADER
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5270685A (en) 1991-07-02 1993-12-14 Mallinckrodt Medical, Inc. Syringe pressure monitor
DE59202070D1 (en) 1991-07-24 1995-06-08 Medico Dev Investment Co Injector.
IL102941A0 (en) 1991-08-27 1993-01-31 Thomas R Johnson Injection syringe
DK175491D0 (en) 1991-10-18 1991-10-18 Novo Nordisk As APPARATUS
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
DK194291D0 (en) 1991-11-29 1991-11-29 Novo Nordisk As SPRAY FOR AUTOMATIC INJECTION.
WO1993010839A1 (en) 1991-11-29 1993-06-10 Novo Nordisk A/S A pen-shaped syringe
KR0152279B1 (en) 1991-11-30 1998-10-15 히로가즈 마츠이 Edge light panel and its production
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
CH682806A5 (en) 1992-02-21 1993-11-30 Medimpex Ets Injection device.
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
JPH0634825A (en) 1992-07-20 1994-02-10 Shiyoudenshiya:Kk Optical fiber connection box
JP3132910B2 (en) 1992-08-07 2001-02-05 積水化学工業株式会社 Nozzle for spraying resin liquid in plate manufacturing equipment
US5404380A (en) * 1992-08-25 1995-04-04 Alcatel Network Systems, Inc. Desynchronizer for adjusting the read data rate of payload data received over a digital communication network transmitting payload data within frames
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
DE69329774T2 (en) 1992-10-15 2001-06-21 Gen Hospital Corp INFUSION PUMP WITH ELECTRONICALLY LOADABLE MEDICINE LIBRARY
US5545147A (en) 1992-10-20 1996-08-13 Eli Lilly And Company Anti-backup improvement for hypodermic syringes
FR2697434A1 (en) 1992-11-02 1994-05-06 Godillon Jean Francois Surgical syringe plunger withdrawal attachment - has lever and transmission member which allow plunger to be withdrawn with one hand, leaving other one free
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
DK145792D0 (en) 1992-12-03 1992-12-03 Dumex Ltd As fluid dispensing apparatus
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
JP2530150Y2 (en) 1993-01-06 1997-03-26 城田電気炉材株式会社 Injection device for dental anesthetic, etc.
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5292976A (en) 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
SE9301494D0 (en) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A DEVICE FOR DOSING LIQUID PREPARATION
GB9309151D0 (en) 1993-05-04 1993-06-16 Zeneca Ltd Syringes and syringe pumps
ATE209052T1 (en) 1993-06-30 2001-12-15 Hamilton Co MANUAL DISPENSING AID FOR AN INJECTION SYRINGE
DK83093D0 (en) 1993-07-09 1993-07-09 Novo Nordisk As COURSE OF ACTION
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2129284C (en) 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
JPH09510775A (en) 1993-12-22 1997-10-28 アイティーティー・オートモーティブ・ヨーロップ・ゲーエムベーハー Device for detecting rotational or angular movement
US5505697A (en) 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
AUPM348594A0 (en) 1994-01-21 1994-02-17 University Of Melbourne, The Improvements in syringe pumps
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
DE4414744C1 (en) 1994-04-27 1995-11-02 Eppendorf Geraetebau Netheler Repeater pipette
EP1228777B1 (en) 1994-05-30 2003-10-29 B D Medico S.a.r.l. Injection device
DE4419235C2 (en) 1994-06-01 1999-03-11 Thomas Braeger Hypodermic syringe with a receptacle
AU1595395A (en) 1994-06-15 1996-01-05 Interventional Research Technologies, Inc. Locking device for syringe or like instrument
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US5496286A (en) 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
CA2186869A1 (en) 1994-08-24 1996-02-29 Hideto Yamagata Injection apparatus
GB9418122D0 (en) 1994-09-08 1994-10-26 Owen Mumford Ltd Improvements relating to injection devices
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
BR9508847A (en) 1994-09-20 1999-11-30 Novo Nordisk A S E Slagterisel Process to treat an aqueous protein solution and to produce a meat-based foodstuff, heat-treated protein / hydrolyzate mixture, or heat-treated liquid hydrolyzate, meat-based foodstuff and use of the meat solution mixture heat-treated protein / hydrolyzate, or heat-treated liquid hydrolyzate
US5533970A (en) 1994-09-28 1996-07-09 Becton, Dickinson And Company Retractable needle syringe
ZA958073B (en) 1994-09-28 1996-04-23 Anthony William Manicom Method of and apparatus for administering a drug to a patient
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
DE19503230A1 (en) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Syringe with a damping and pressure measuring device integrated in the piston and method for uniform and pressure-controlled injection by means of this syringe
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
CA2213682C (en) * 1995-03-07 2009-10-06 Eli Lilly And Company Recyclable medication dispensing device
GB2309644B (en) 1995-05-22 2000-05-31 Wolfgang Wagner A method and device for diagnosis and injection
CA2222411C (en) 1995-06-02 2007-09-11 Novo Nordisk A/S A syringe with an exchangeable cartridge
US5700904A (en) 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (en) 1995-08-21 1997-01-02 Adamaszek Franz Heinz Dosing and automatic injection system
US5779675A (en) 1995-08-25 1998-07-14 Medrad, Inc. Front load pressure jacket system with syringe holder
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
KR100469207B1 (en) 1995-10-20 2005-03-16 화이자 헬스 에이비 Arrangement in electronically controlled injection devices
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
FR2740345A1 (en) 1995-10-26 1997-04-30 Neftel Frederic AUTOMATION DEVICE
JPH09166474A (en) 1995-12-19 1997-06-24 Omron Corp Residual-quantity sensor
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
JP4472026B2 (en) 1996-02-23 2010-06-02 ノボ ノルディスク アクティーゼルスカブ Syringe with electronic representation of parameters
FR2745637B1 (en) 1996-03-04 1998-05-22 Motorola Semiconducteurs SEMICONDUCTOR CHEMICAL SENSOR DEVICE AND THERMOCOUPLE FORMING METHOD THEREFOR
BR9707986A (en) 1996-03-12 1999-07-27 Novo Nordisk Injection device
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
JP2000506534A (en) 1996-03-15 2000-05-30 ノボ ノルディスク アクティーゼルスカブ Method for purifying protein from protein-containing solution
ATE224216T1 (en) 1996-04-02 2002-10-15 Disetronic Licensing Ag INJECTION DEVICE
WO1997036626A1 (en) 1996-04-02 1997-10-09 Disetronic Licensing Ag Injection device
DE29606540U1 (en) 1996-04-10 1997-08-07 Muehlbauer Ernst Dental mass application device
WO1997039787A1 (en) 1996-04-24 1997-10-30 Novo Nordisk A/S Injection needle
CA2258309A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Flexible piston rod
CA2258491A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Automatic needle insertion mechanism
DE69729300T2 (en) 1996-07-05 2005-08-04 Novo Nordisk A/S DOSING
DE19632402C1 (en) 1996-08-02 1998-04-09 Schering Ag Method of making a prefilled, sterile syringe
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
DK0927057T3 (en) 1996-09-13 2003-09-01 Novo Nordisk As Dose display means for a syringe
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
JP2001501504A (en) 1996-09-20 2001-02-06 ノボ ノルディスク アクティーゼルスカブ Working cylinder
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
US6030368A (en) 1996-09-20 2000-02-29 Azam Anwar Power syringe having a base and a lever
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
EP0971760A1 (en) 1997-02-04 2000-01-19 Novo Nordisk A/S A device for the administration of a liquid medicament suspension
DE29703820U1 (en) 1997-03-03 1998-07-02 Medico Dev Investment Co Injection device
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
RU2111019C1 (en) 1997-05-22 1998-05-20 Сергей Александрович Хворостов General-purpose injector
DE19723647C1 (en) 1997-06-05 1998-12-24 Disetronic Licensing Ag Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
AU7331598A (en) 1997-07-11 1999-02-08 Novo Nordisk A/S An apparatus for the registration of the setting of a medical device
ATE240755T1 (en) 1997-07-14 2003-06-15 Novo Nordisk As CYLINDRICAL AMPOULE
JP2003514587A (en) 1997-07-14 2003-04-22 ノボ ノルディスク アクティーゼルスカブ Injection parts
DE19730999C1 (en) 1997-07-18 1998-12-10 Disetronic Licensing Ag Injection pen dosing selected volume of fluid, especially insulin
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
SE9702872D0 (en) 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5957896A (en) 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
FR2767479B1 (en) 1997-08-22 1999-10-22 Aguettant Lab DRUG INJECTION DEVICE
AU9202398A (en) 1997-09-29 1999-04-23 Becton Dickinson & Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
CH692543A5 (en) 1997-09-25 2002-07-31 Disetronic Licensing Ag Dispenser with auto switch.
US5896789A (en) 1997-10-09 1999-04-27 Chicago Pneumatic Tool Company Ratchet wrench head
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
AU748277B2 (en) 1998-01-30 2002-05-30 Novo Nordisk A/S An injection syringe
US6770288B2 (en) 1998-02-13 2004-08-03 Pfizer Products Inc. Drug delivery system
US6096010A (en) 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
JP3436683B2 (en) 1998-03-17 2003-08-11 株式会社日立ユニシアオートモティブ Rotation angle detector
JP4425465B2 (en) 1998-03-23 2010-03-03 エラン コーポレーション ピーエルシー Drug delivery device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE19822031C2 (en) 1998-05-15 2000-03-23 Disetronic Licensing Ag Auto injection device
JP3017167B2 (en) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Method and apparatus for binarizing a read signal from a data storage medium
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
US6743202B2 (en) 1998-06-15 2004-06-01 Medrad, Inc. Encoding of syringe information
DE69913344T2 (en) 1998-06-15 2004-10-14 Medrad, Inc. CODING SYRINGE INFORMATION
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
EP1094857B1 (en) 1998-07-08 2003-10-08 Novo Nordisk A/S A medical delivery device and a cartridge assembly for use in the same
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
DE19838760A1 (en) 1998-08-26 2000-04-20 Bauer Jlona Injection unit, especially for injecting medicines such as insulin, consists of a housing with a chamber for holding a needle, a cartridge and a release mechanism.
CN1317967A (en) 1998-09-17 2001-10-17 伊莱利利公司 Protein formulations
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
AU1794700A (en) 1998-12-22 2000-07-12 Alcor Medical Instruments Ltd. Method and device for monitoring fluid level
DK1140148T3 (en) 1998-12-22 2006-01-30 Lilly Co Eli Stable storage formulation of glucagon-like peptide-1
DE19900792C1 (en) 1999-01-12 2000-06-15 Disetronic Licensing Ag Injection unit forming part of e.g. pen-type self-injection syringe has continuous dosing stop in spiral form with constant pitch ensuring close fine control and accuracy in use
DE29900482U1 (en) 1999-01-14 2000-08-31 Medico Dev Investment Co Injection device
US6036675A (en) 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
JP2000237308A (en) 1999-02-22 2000-09-05 Ckd Corp Infusion pump
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
AU3721500A (en) 1999-03-05 2000-09-21 Accumed Systems, Inc. High pressure syringe
DE19909602A1 (en) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Device for drawing blood for diagnostic purposes
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
SE9901736D0 (en) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
JP4290366B2 (en) 1999-08-05 2009-07-01 ベクトン・ディキンソン・アンド・カンパニー Drug delivery pen
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
IL148956A0 (en) 1999-10-12 2002-11-10 Novo Nordisk As Air shot mechanism for electronic injection devices
JP4236842B2 (en) 1999-10-22 2009-03-11 アンタレス・ファーマ・インコーポレーテッド Medical syringe and drug loading system used therewith
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
JP2003525667A (en) 2000-02-16 2003-09-02 ベー デー メディコ エス．アー．エル．エル． Injection reconstitution method and injection device for performing the method
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
DE10018827A1 (en) 2000-04-15 2001-10-25 Vetter & Co Apotheker Syringe used in medicine comprises cylinder with thin tube at one end, movable plunger with piston rod, and protective sleeve.
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
AU2001278417A1 (en) 2000-07-14 2002-01-30 Novo-Nordisk A/S A liquid medication delivery device and a method of delivering an intended dose
CN1466471A (en) 2000-07-28 2004-01-07 MDCͶ�ʿعɹ�˾ Retractable needle medical device for injecting fluid from a pre-filled cartridge
WO2002011629A1 (en) 2000-08-10 2002-02-14 Synthes Ag Chur Device for the introduction of medical items
US6994261B2 (en) 2000-08-10 2006-02-07 Novo Nirdisk A/S Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
WO2002024257A1 (en) 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
JP4975208B2 (en) 2000-10-03 2012-07-11 株式会社根本杏林堂 Automatic injection equipment
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
JP2004522497A (en) 2000-11-24 2004-07-29 シー ケー エム ダイアグノスティクス インコーポレーテッド Neurostimulator output control needle with depth determination function and method of using same
ATE555185T1 (en) 2000-12-21 2012-05-15 Rentech Inc BIOMASS GASIFICATION PROCESS TO REDUCE ASH AGGLOMERATION
US6461328B2 (en) 2000-12-21 2002-10-08 Uniqsafe Medical Technology Group Ltd. Safety syringe
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
DE60224167T2 (en) 2001-02-14 2008-12-04 Novo Nordisk A/S ELECTRONICALLY CONTROLLED INJECTION OR INFUSION DEVICE
GB0107607D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
GB0107601D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to and injection device
GB0107600D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
GB0107604D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to injection device
WO2002083209A1 (en) 2001-04-13 2002-10-24 Nipro Diabetes Systems Drive system for an infusion pump
CA2689022C (en) 2001-05-16 2012-09-18 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US6752781B2 (en) 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
DE10133216B4 (en) 2001-07-09 2005-01-27 Tecpharma Licensing Ag position detection
DE10163326A1 (en) 2001-07-30 2003-02-27 Disetronic Licensing Ag Administration device with dosing device
US7235063B2 (en) 2001-08-21 2007-06-26 D'antonio Consultants International, Inc. Hypodermic injection system
EP2319562B1 (en) 2001-12-13 2012-05-30 Panasonic Corporation Administration instrument for medical use
GB0130138D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in an relating to a medicament injection apparatus
DE20209051U1 (en) 2001-12-21 2003-04-24 Disetronic Licensing Ag Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop
GB0200444D0 (en) * 2002-01-10 2002-02-27 Owen Mumford Ltd Improvements relating to medical injection devices
GB0200637D0 (en) 2002-01-12 2002-02-27 Dca Design Int Ltd Improvements in and relating to medicament injection apparatus
DE10201875C1 (en) 2002-01-18 2003-05-22 Austriamicrosystems Ag Magnetic or electrical field sensor system has modulators with non-inverting and inverting conditions providing for different sensor configurations
US7169107B2 (en) 2002-01-25 2007-01-30 Karen Jersey-Willuhn Conductivity reconstruction based on inverse finite element measurements in a tissue monitoring system
AU2003209475A1 (en) 2002-03-07 2003-09-16 Vectura Limited Fast melt multiparticulate formulations for oral delivery
EP1487520A1 (en) 2002-03-18 2004-12-22 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
JP4064138B2 (en) 2002-03-28 2008-03-19 スーガン株式会社 Medical tube opener
US20040010204A1 (en) 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP2003296915A (en) 2002-03-29 2003-10-17 Tdk Corp Magnetic recording medium
AU2003233504A1 (en) 2002-05-24 2003-12-12 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
DE10226643A1 (en) 2002-06-14 2004-01-15 Disetronic Licensing Ag Piston stopper for injection device, product container and injection device
DE10229122B4 (en) 2002-06-28 2006-09-07 Tecpharma Licensing Ag Administration device with resettable actuation lock
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
EP1521607A1 (en) 2002-07-10 2005-04-13 Novo Nordisk A/S An injection device with a dose setting limiter
AU2003239784A1 (en) 2002-07-10 2004-02-02 Novo Nordisk A/S An injection device
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
US6929619B2 (en) 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
DE10237258B4 (en) 2002-08-14 2006-09-21 Tecpharma Licensing Ag injection device
JP2005536300A (en) 2002-08-29 2005-12-02 ノボ・ノルデイスク・エー／エス Forward retractable injection device
DE10240166A1 (en) 2002-08-30 2004-03-18 Disetronic Licensing Ag Injection syringe for dispensing insulin to treat diabetes has piston operated by flexible belt which is moved by manually-operated wheel with teeth which cooperate with catches set to give predetermined dose
DE10240165A1 (en) 2002-08-30 2004-03-18 Disetronic Licensing Ag Dispensing unit for use in infusion pumps comprises reservoir for infusion liquid fitted with spring-loaded piston, toothed wheel cooperating with locking bar to prevent piston moving
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
DK1542744T3 (en) 2002-09-24 2009-09-28 Shl Group Ab injection device
EP1557163A4 (en) 2002-09-26 2009-03-18 Japan Science & Tech Agency Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
EP1554000A2 (en) 2002-10-15 2005-07-20 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
GB0229345D0 (en) 2002-12-17 2003-01-22 Safe T Ltd Hollow needle applicators
US20050019400A1 (en) 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
EP1603458A1 (en) 2003-03-06 2005-12-14 Lifescan, Inc. System and method for piercing dermal tissue
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
DE602004015432D1 (en) 2003-03-24 2008-09-11 Novo Nordisk As TRANSPARENT ELECTRONIC MARKING OF A MEDICATION CONTAINER
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
MXPA05011377A (en) 2003-04-23 2006-01-30 Vasogen Ireland Ltd Dispensing systems.
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
FR2857654B1 (en) 2003-07-16 2007-04-27 Prodonta DEVICE FOR EJECTING A LIQUID OR PASTY PRODUCT
DK1656170T3 (en) 2003-08-12 2019-04-29 Lilly Co Eli Drug delivery device with three screw threads for mechanical advantage
US7708732B2 (en) 2003-10-16 2010-05-04 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
DE20317377U1 (en) 2003-11-03 2005-03-17 B D Medico S A R L injection device
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
CN105641776B (en) 2004-03-03 2021-03-30 株式会社根本杏林堂 Chemical solution injection system, chemical solution injection device, and chemical solution heat-insulating device
GB0406088D0 (en) 2004-03-18 2004-04-21 Smiths Group Plc Infusion apparatus and methods
DK1732628T3 (en) 2004-03-30 2011-10-24 Lilly Co Eli Medication dispenser with gear set with opening for a drive element
AU2005231731B2 (en) 2004-03-30 2010-12-23 Eli Lilly And Company Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
DE202004006611U1 (en) 2004-04-23 2005-08-25 Tecpharma Licensing Ag Injection device for administering an injectable product with secured dosing device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
JP4836947B2 (en) 2004-07-05 2011-12-14 ノボ・ノルデイスク・エー／エス Credit card size injection device
EP1782853A4 (en) 2004-07-14 2009-09-16 Nemoto Kyorindo Co Ltd Medical liquid injection system
AU2005279795A1 (en) 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl PDE4B inhibitors
DE102004046003A1 (en) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmaceutical package, as a syringe or vial or capsule, has an integrated microchip and antenna to give a unique and tamper-proof identity
PT1799287E (en) 2004-10-04 2013-08-30 Sanofi Aventis Deutschland Drive mechanism for a drug delivery device
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
EP1819384A1 (en) 2004-10-14 2007-08-22 Novo Nordisk A/S Syringe with dosis mechanism
JP4990151B2 (en) 2004-10-21 2012-08-01 ノボ・ノルデイスク・エー／エス Syringe with internal dose indicator
ATE444090T1 (en) 2004-10-21 2009-10-15 Novo Nordisk As SELECTION MECHANISM FOR A ROTARY PIN
DE602005018518D1 (en) 2004-10-21 2010-02-04 Novo Nordisk As INJECTION DEVICE WITH A PROCESSOR FOR COLLECTING OUTPUT INFORMATION
RU2388498C2 (en) 2004-10-21 2010-05-10 Ново Нордиск А/С Device for injections furnished with torsional spring and rotary indicator
ITVR20040168A1 (en) 2004-10-25 2005-01-25 C M Tecnologie S R L SELECTOR, PARTICULARLY BUT NOT ONLY FOR AUTOMATIC DRINK DISTRIBUTORS
WO2006052737A1 (en) 2004-11-04 2006-05-18 Sid Technologies, Llc Automatic injector
DE102004063648A1 (en) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Injection or infusion device with life-determining device
CA2594764C (en) 2005-01-21 2014-01-14 Novo Nordisk A/S An automatic injection device with a top release mechanism
JP2006250582A (en) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd Rfid tag with load sensor
WO2006114396A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S Injection device
US20080221530A1 (en) 2005-04-24 2008-09-11 Novo Nordisk A/S Injection Device With A GearBox
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK200500116U3 (en) 2005-05-23 2005-06-24 Novo Nordisk As Motor-powered injection apparatus
PL208660B1 (en) 2005-05-25 2011-05-31 Kappa Medilab Społka Z Ograniczoną Odpowiedzialnością Automatic applicator, particularly for application of the insulin
CN101184519B (en) 2005-05-31 2011-08-31 诺和诺德公司 Injection device with visual end-of-content indication
EP1728529B2 (en) 2005-06-01 2016-07-27 SHL Group AB Device for delivering medicament
CN101227942B (en) 2005-07-27 2010-10-20 诺沃-诺迪斯克有限公司 Syringe device with a dose limiting mechanism and an additional safety mechanism
NO332933B1 (en) 2005-08-18 2013-02-04 Rolls Royce Marine As System for handling a wire, chain and cable on board a vessel
DE102005060929A1 (en) 2005-09-14 2007-03-15 Tecpharma Licensing Ag Product e.g. insulin, injecting device, has housing and operating knob with locking units that are formed such that movement of operating knob in one direction has smaller resistance in contrast to movement in other direction
US20090043253A1 (en) 2005-10-11 2009-02-12 Blake Podaima Smart medical compliance method and system
GB0524604D0 (en) 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
US20070167916A1 (en) 2006-01-16 2007-07-19 Linfair Engineering (Hk) Co., Ltd. Outer barrel for a syringe
EP1996259B1 (en) 2006-03-10 2012-08-15 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
CN101400394B (en) 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 An injection device having a gearing arrangement
US20090069756A1 (en) 2006-03-20 2009-03-12 Novo Nordisk A/S Determination of Cartridge Content by Capacitive Means
WO2007107561A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of position of injection needle
WO2007132019A1 (en) 2006-05-16 2007-11-22 Novo Nordisk A/S A gearing mechanism for an injection device
JP5253387B2 (en) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー／エス Injection device with mode locking means
WO2008003130A1 (en) 2006-07-05 2008-01-10 Kaliopi Papantoniou A method and composition for treating the scalp
CN101563123B (en) 2006-09-15 2012-08-29 特克法马许可公司 Injection device comprising an improved delivery element
CN102895718B (en) 2006-09-29 2015-01-14 诺沃—诺迪斯克有限公司 An injection device with electronic detecting means
CN101528285B (en) 2006-10-26 2012-10-31 马林克罗特有限公司 Medical fluid injector having a thermo-mechanical drive
US7621842B2 (en) 2007-02-14 2009-11-24 Shimano Inc. Bicycle hub assembly
DE102007016811A1 (en) 2007-04-05 2008-10-09 Tecpharma Licensing Ag Device for administering a fluid substance from a multi-chamber ampoule
US20080306443A1 (en) 2007-06-06 2008-12-11 Mallinckrodt Inc. Medical Fluid Injector Having Wireless Pressure Monitoring Feature
US8992484B2 (en) 2008-01-23 2015-03-31 Novo Nordisk A/S Device for injecting apportioned doses of liquid drug
AT506690B1 (en) 2008-06-16 2009-11-15 Pharma Consult Ges M B H & Co INJECTION DEVICE
CN102196835B (en) 2008-10-24 2014-08-27 诺沃—诺迪斯克有限公司 Dial-down mechanism for wind-up pen
EP2470245B1 (en) 2009-08-24 2018-05-16 SHL Group AB Dose reset mechanism
PL215310B1 (en) 2009-10-30 2013-11-29 Kappa Medilab Spolka Z Ograniczona Odpowiedzialnoscia Automatic applicator, especially for insulin
CN102946931B (en) 2010-04-26 2015-09-16 Shl集团有限责任公司 Medicament delivery device
EP2438940A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
GB2484490A (en) 2010-10-12 2012-04-18 Owen Mumford Ltd Frangible needle shield for syringe
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
MX2014013842A (en) 2012-05-31 2015-02-18 Novo Nordisk As Dial-down mechanism for wind-up pen.

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CN101060874A (en) 2007-10-24
ATE444090T1 (en) 2009-10-15
KR20070084393A (en) 2007-08-24
WO2006045526A1 (en) 2006-05-04
US7686786B2 (en) 2010-03-30
DK1804865T3 (en) 2010-02-01
IL182613B (en) 2019-09-26
PL1804865T3 (en) 2010-03-31
USRE46363E1 (en) 2017-04-11
JP4698677B2 (en) 2011-06-08
CN100571804C (en) 2009-12-23
CA2584760C (en) 2013-12-24
US20080147005A1 (en) 2008-06-19
DE602005016952D1 (en) 2009-11-12
AU2005298944A1 (en) 2006-05-04
CA2584760A1 (en) 2006-05-04
JP2008516712A (en) 2008-05-22
AU2005298944B2 (en) 2010-12-23
KR101300496B1 (en) 2013-09-02
ES2334046T3 (en) 2010-03-04
RU2007114761A (en) 2008-11-27
ZA200703707B (en) 2009-02-25
EP1804865A1 (en) 2007-07-11
RU2389514C2 (en) 2010-05-20

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