EP1438029A2 - Method and system for non-vascular sensor implantation - Google Patents
Method and system for non-vascular sensor implantationInfo
- Publication number
- EP1438029A2 EP1438029A2 EP02780519A EP02780519A EP1438029A2 EP 1438029 A2 EP1438029 A2 EP 1438029A2 EP 02780519 A EP02780519 A EP 02780519A EP 02780519 A EP02780519 A EP 02780519A EP 1438029 A2 EP1438029 A2 EP 1438029A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- sensor
- implant unit
- sensing elements
- area
- physiological parameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6879—Means for maintaining contact with the body
- A61B5/6882—Anchoring means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
Definitions
- Embodiments of the present invention claim priority from a U.S. Provisional Application, Serial No. 60/335,627, filed October 23, 2001 and from a U.S. Application, Serial No. 10/034,627, filed December 27, 2001, each entitled “Method and System for Non- Vascular Sensor Implantation,” and from a U.S. Provisional Application, Serial No. 60/414,290, filed September 27, 2002, the contents of all of which are incorporated by reference herein.
- the present invention relates to the field of in vivo sensors and, in particular, to in vivo sensors that are implanted in non- vascular areas of the body.
- the present invention also relates to a system and method for accurately measuring a physiological parameter in areas of a body (or external to the body) where amounts of the physiological parameter are heterogeneous in nature.
- vascular placement of a physiological parameter sensor typically rely on vascular placement of a physiological parameter sensor.
- a sensing element such as, for example, a biomolecule
- Such sensing capabilities have greatly facilitated analysis, diagnosis and treatment of many debilitating diseases and medical conditions.
- vascular placement of a physiological parameter sensor may suffer from several disadvantages.
- a physiological parameter sensor is not inserted into a vein without great difficulty and painstaking effort by an attending physician.
- a physiological parameter sensor is not adjusted within or extracted from a vein without similar difficulty and effort.
- vascular placement of a physiological parameter sensor subjects the sensor to a constant fluid environment.
- Such an environment may have several detrimental effects on the sensor. Due to constant fluidic contact, the sensor may suffer from decreased sensitivity, stability and effective life. Should a characteristic of the sensor be diminished to an extent rendering the sensor ineffective, the sensor must be removed and replaced, introducing the difficulties for both patient and physician associated with such removal and replacement.
- every time a physiological parameter sensor is removed and replaced it must be disconnected and reconnected to an implant unit utilizing the sensor output.
- integrated sensor/implant unit systems have been developed. Such systems may be placed in or near a body cavity and may provide non- vascular sensing of physiological parameters.
- physiological parameter sensors allow the sensing elements to sense a relatively homogenous amount of oxygen or other physiological parameter as it flows past the sensing elements.
- the physiological parameter may have a more heterogeneous nature, i.e., the amount of the physiological parameter may vary significantly at different locations within the non-vascular area.
- the sensing element may sense the physiological parameter through diffusion from, for example, fluid around the sensing element.
- the amount of the physiological parameter sensed by the sensing element may more or less accurately represent the "overall amount" of the physiological parameter within the non- vascular area, i.e., an amount that accurately represents, for example, an average amount or other suitable statistical measure of the physiological parameter in the particular area of the body.
- an amount that accurately represents, for example, an average amount or other suitable statistical measure of the physiological parameter in the particular area of the body may be more or less accurately represent the "overall amount" of the physiological parameter within the non- vascular area.
- an amount that accurately represents, for example, an average amount or other suitable statistical measure of the physiological parameter in the particular area of the body may induce noise in the signal obtained from the sensing element.
- Embodiments of the present invention relate to systems and methods for non- vascular sensor implantation and to a system and method for accurately measuring a physiological parameter in areas of a body (or external to the body) where amounts of the physiological parameter are heterogeneous in nature.
- a method for non-vascular implant of a sensor may include implanting an implant unit in an area of a body; allowing a foreign body capsule to form around the area of the implant unit; and directing the sensor into the foreign body capsule.
- Implanting an implant unit may include incising an area of the body large enough for the implant unit. Allowing a foreign body capsule to form may comprise inserting materials around the implant unit to promote growth characteristics. A material may be placed around the implant unit for promoting growth characteristics.
- the implant unit may include electronics and/or a pump.
- the electronics may be sensor electronic or other electronics.
- the electronics may be integrated with the pump or may be mutually exclusive from the pump.
- the sensor may be attached to the implant unit.
- the sensor may be attached to the implant unit prior to formation of the foreign body capsule or may be attached to the implant unit subsequent to formation of the foreign body capsule.
- the method may further include incising an area of the body large enough for the sensor. The incised area of the body large enough for the sensor is smaller than an incised area of the body large enough for the implant unit.
- a method for non-vascular implant of a sensor may also include incising an area of a body large enough for inserting an implant unit; incising an area remote from a sensor location for inserting a sensor; directing the sensor into a body cavity; connecting the sensor to the implant unit; and inserting the implant unit into the body.
- the method may further include fixing the sensor in place using suture.
- the implant unit may be inserted into a pocket formed when incising an area of the body large enough for inserting the implant unit.
- Systems for non-vascular implant may include an implant unit for delivering drug to a human body and a sensor for detecting a physiological parameter.
- the sensor may be separate from and connectable to the implant unit and the sensor is placed in a non-vascular area of the human body.
- the implant unit may include a pump and/or electronics.
- the drug delivered by the implant unit may be insulin.
- the sensor may include a biomolecule, a lead and a sensing element.
- the sensing element may be a biomolecule and the biomolecule may be a glucose oxidase enzyme.
- the physiological parameter sensed may be oxygen or glucose.
- the non- vascular area of the human body where the sensor is placed may be the peritoneum or subcutaneous tissue.
- a plurality of spatially separated sensing elements may be used for detecting the physiological parameter.
- the sensing elements may be connectable to the implant unit.
- the sensing elements may be implanted in a non- vascular area of the body such that each of the sensing elements sense an individual amount of the physiological parameter within the area.
- the sensing elements may substantially simultaneously sense individual amounts of the physiological parameter or may sense the individual amounts in succession within a given time period. An overall amount of the physiological parameter in the area may then be determined by employing a combination of the individual sensed amounts in a statistical analysis, such as in an algorithm or combined calculation.
- the plurality of spatially separated sensing elements may be a one, two, or three-dimensional array of spatially separated sensing elements. Two or more sensing elements may be spatially separated in a sensor lead by a pre-determined distance.
- the sensor lead may include a first sensing element located at a proximal end of the sensor lead and a second sensing element located at a distal end of the sensor lead.
- the sensing elements may be connected to the implant unit in a daisy chain fashion.
- Each of the plurality of spatially separated sensing elements may generate a signal representing an individual sensed amount of the physiological parameter.
- the overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts represented by the generated signals.
- the statistical measurement may be, but is not limited to, a maximum amount for the individual sensed amounts, an average amount of the individual sensed amounts, a median of the individual sensed amounts, an arithmetic mean of the individual sensed amounts, a weighted arithmetic mean of the individual sensed amounts, or the like. In this manner, a more accurate overall measurement of the physiological parameter is possible.
- noise induced in the signals produced by the sensing elements may be reduced by averaging the amounts of each of the plurality of spatially separated sensing elements.
- Embodiments of the present invention may also include a method for non-vascular implant of a sensor including incising an area of a body large enough for inserting an implant unit; creating a tunnel in subcutaneous tissue; directing the sensor through the tunnel; connecting the sensor to the implant unit; and inserting the implant unit into the body.
- the tunnel may be created using a blunt instrument such as, for example, a trocar, or other blunt instrument which minimizes trauma to the subcutaneous tissue.
- Embodiments of the present invention may also include a structure for defining an in vivo implant site, the structure including a cylinder having a hollow area in an interior portion thereof, wherein a portion of the cylinder is covered with a coating.
- the coating may be silicone rubber and the cylinder may be a right circular cylinder.
- the hollow area may be sufficiently large to accept a sensor.
- the cylinder may have at least one hole in an outer surface thereof.
- Figure 1 shows a general position of an implant unit and a sensor in the human body according to an embodiment of the present invention.
- Figure 2 shows a generalized implant unit and a sensor according to an embodiment of the present invention.
- Figure 3 A shows a process for making a non-vascular placement of a sensor into a foreign body capsule according to an embodiment of the present invention
- Figure 3B shows a process for making a non-vascular placement of a sensor into a body cavity such as, for example, the peritoneal space, according to an embodiment of the present invention.
- Figure 3C shows a process for making a non-vascular placement of a sensor into subcutaneous tissue according to an embodiment of the present invention.
- Figure 4 shows a biopsy trocar used according to an embodiment of the present invention.
- Figure 5 A shows glucose data over a period of several days for a sensor implanted into a foreign body capsule according to an embodiment of the present invention.
- Figure 5B shows glucose data over a period of several days for a sensor implanted into subcutaneous tissue according to an embodiment of the present invention.
- Figure 5C shows glucose data over a period of several days for a sensor implanted into a body cavity such as a peritoneal space according to an embodiment of the present invention.
- Figure 6 shows a blood oxygenator in which a sensing element may be placed, according to an embodiment of the present invention.
- Figure 7 shows a sensor lead including two sensing elements according to an embodiment of the present invention.
- Figure 8 shows a graphical representation of glucose data over a period of several days for each of two sensing elements of a sensor lead implanted into the peritoneum according to an embodiment of the present invention.
- Figure 9 shows a graphical representation of the average of the glucose data for the two sensing elements of Figure 7 over the same period according to an embodiment of the present invention.
- Figure 10 shows a graphical representation of unfiltered glucose data over a period of several days for a sensing element of a sensor lead implanted into the peritoneum according to an embodiment of the present invention.
- Figure 11 shows a graphical representation of filtered glucose data for the sensing element of Figure 10 over the same period according to an embodiment of the present invention.
- Figure 12 shows a graphical representation of the unfiltered average of the glucose data for the two sensing elements of Figure 7 over a period of several days according to an embodiment of the present invention.
- Figure 13 shows a graphical representation of the filtered average of the glucose data for the two sensing elements of Figure 7 over the same period according to an embodiment of the present invention.
- Figure 14 shows a perspective view of a placement site structure according to an embodiment of the present invention.
- FIG. 1 shows a general placement of an implant unit 10 and a sensor 12 in the human body according to an embodiment of the present invention.
- the implant unit 10 may be placed into a human body in a variety of locations such as, for example, adjacent to the abdominal cavity 14, or in other locations such as, for example, the spinal cavity or chest cavity.
- a sensor 12 connecting to the implant unit 10 may be located in the peritoneum 13, the membrane lining the abdominal cavity and connecting and supporting internal organs; in subcutaneous tissue 13, i.e., tissue beneath the skin; in a foreign body capsule; or in another area of the body.
- the sensor 12 may be implanted into the shoulder area .
- the implant unit 10 may contain electronics for data acquisition, data storage, data processing or other functions as may be required for physiological parameter sensing.
- the implant unit 10 may also contain, for example, a drug delivery system including a drug reservoir and a pumping mechanism to move a drug from the reservoir to a patient through, for example, a delivery catheter.
- the sensor 12 may sense a variety of physiological parameters.
- the sensor 12 may sense glucose and oxygen and may be used in connection with the implant unit 10 to pump insulin for diabetics.
- Figure 2 shows a generalized implant unit 10 and a sensor 12 according to an embodiment of the present invention.
- the implant unit 10 and the sensor 12 are not integrated. They are discreet devices and may or may not be used independently of one another.
- the implant unit 10 and the sensor 12 may be used in conjunction with one another and may be inserted into a patient at separate times. The ability to insert the implant unit 10 and the sensor 12 into a patient at different times gives physicians and patients enhanced flexibility when implanting the devices.
- the senor 12 includes a connector 18, a sensor lead 20 connected to the connector at one end, and a sensing element 22 connected to the sensor lead 20 at another end.
- the sensing element 22 of the sensor 12 may be located away from the implant unit 10 which, as will be seen shortly, offers enhanced functionality in sensing physiological parameters.
- the implant unit 10 may include a receptacle 16 for accepting the connector 18 portion of the sensor 12.
- the sensor lead 20 is not limited to any particular length.
- the sensor lead 20 may be approximately nine inches long, permitting the sensing element 22 to be approximately nine inches from the implant unit 10.
- FIG. 3 A shows a process for making a non-vascular placement of the sensor 12 into a foreign body capsule according to an embodiment of the present invention.
- a large incision may be made in the body at a desired or convenient location for the implant unit 10.
- a pocket may be made in the subcutaneous tissue that is large enough to support the implant unit 10.
- the implant unit 10 may be inserted into the subcutaneous tissue pocket.
- the pocket may then be closed.
- the implant unit 10 may be left in the body for a period of time long enough that a foreign body capsule forms around the implant unit 10.
- the implant unit 10 may need to be left undisturbed in its position in the body for up to several weeks, a month, or longer in order to allow the foreign body capsule to form.
- the foreign body capsule is made up of scar tissue, primarily collagen and fibrin.
- a sensor 12 may or may not be attached to the implant unit 10. If a sensor 12 is not attached to the implant unit 10, it may still be possible to use the implant unit 10 in an open- loop configuration.
- the implant unit 10 contains telemetry circuitry, it may be possible to communicate with the implant unit 10 from a remote location.
- the implant unit 10 is an insulin pump, and no sensor 12 is attached to the implant unit 10 during the period in which the foreign body capsule is forming around the implant unit 10, the patient may still analyze his or her insulin levels by traditional methods, such as, for example, using a home analysis system to take a blood sample and analyze the levels of insulin in the blood. If it is determined that the patient needs a dosage of insulin, and if the insulin pump which has been placed into the patient's body is equipped with telemetry electronics, the patient may communicate with the insulin pump telemetrically using a portable transmitting unit and command the pump to deliver a dosage of insulin.
- the patient may begin to immediately use the insulin pump, without having a sensor 12 attached to the pump, in an open-loop configuration.
- An oxygen sensor may be used in the vicinity of the foreign body capsule to determine if the foreign body capsule has formed and the area has healed. Generally, no oxygen will be detected during formation of the foreign body capsule.
- a small incision may be made in the vicinity of the implant unit 10 pocket allowing access to the receptacle 16 of the implant unit 10. If a sensor has been previously connected to the implant unit 10, it may be disconnected at this time.
- the sensor 12 may be directed into the foreign body capsule.
- the sensing element 22 may be introduced into the foreign body capsule surrounding the implant unit through the small incision made at step 34.
- the sensing element 22 may be placed within the foreign body capsule.
- the connector 18 may reside in the subcutaneous pocket created for the implant unit 10 by the body.
- a silicone plug may be used to plug the receptacle so that it remains open during the period of time the foreign body capsule is forming around the implant unit. If a silicone plug has been inserted into the receptacle 16, it may also be removed at this time.
- the sensor 12 may be connected to the implant unit 10 at the receptacle 16 on the implant unit 10 designed for connecting to the sensor 12 by connecting the connector 18 to the receptacle 16.
- the small incision may be closed at step 40.
- the implant unit 10 and the sensor 12 may be used in a closed- loop configuration.
- the implant unit 10 is an insulin pump and the sensing element 22 of the sensor 12 contains a glucose oxidase enzyme for sensing glucose and oxygen in order to determine insulin levels in the patient, the glucose and oxygen levels and, consequently, the insulin levels in the patient may be determined by the sensing element 22 in the foreign body capsule.
- Vascular placement of the sensor 12 is not required.
- Figure 3B shows a process for making a non- vascular placement of the sensor 12 into a body cavity such as, for example, the peritoneal space, according to an embodiment of the present invention.
- a large incision may be made in the body at a desired or convenient location for the implant unit 10. While making the incision of step 50, a pocket may be made in the subcutaneous tissue above the cavity to be used that is large enough to support the implant unit 10.
- a small incision may be made in a muscle wall of the cavity such as, for example, the peritoneal space, for allowing implantation of the sensor 12. The small incision may be far or remote from final placement of the sensor 12.
- the sensor 12 may be directed into the cavity.
- the sensing element 22 may be introduced into the cavity through the small incision made at step 52.
- the connector 18 may reside in the subcutaneous pocket created for the implant unit 10 by the body.
- the sensor 12 may be connected to the implant unit 10 at the receptacle 16 on the implant unit 10 designed for connecting to the sensor 12 by connecting the connector 18 to the receptacle 16.
- the implant unit 10 may be inserted into the subcutaneous tissue pocket created at step 50. After the implant unit 10 has been inserted into the subcutaneous tissue pocket, the pocket may be closed at step 60.
- FIG. 3C shows a process for making a non-vascular placement of the sensor 12 into subcutaneous tissue according to an embodiment of the present invention.
- a large incision may be made in the body at a desired or convenient location for the implant unit 10. While making the incision of step 70, a pocket may be made in the subcutaneous tissue above the cavity to be used that is large enough to support the implant unit 10.
- a small tunnel may be made for the sensor at the edge of pocket created for the implant unit 10. An incision for the tunnel may be made far or remote from final placement of the sensor 12.
- the tunnel may be made using a blunt, minimally traumatic tissue implant.
- the sensor 12 may be tunneled through the subcutaneous tissue by starting at an edge of the implant unit 10 pocket and tunneling into the subcutaneous tissue parallel to the skin. It may be desirable to stay within the subcutaneous tissue while tunneling. If the blunt, minimally traumatic tissue implant device used includes an introducer, the introducer may be left in the subcutaneous tissue while the remaining portion of the blunt, minimally traumatic tissue implant device may be removed. After the tunnel has been made, at step 74 the sensing element 22 of sensor 12 may be directed into the introducer of the blunt, minimally traumatic tissue implant device.
- the connector 18 may reside in the subcutaneous pocket created for the implant unit 10 by the body.
- the sensor 12 may be connected to the implant unit 10 at the receptacle 16 on the implant unit 10 designed for connecting to the sensor 12 by connecting the connector 18 to the receptacle 16.
- the implant unit 10 maybe inserted into the subcutaneous tissue pocket created at step 70.
- the pocket may be closed at step 80. As before, at this point the implant unit 10 and the sensor 12 may be used in a closed-loop configuration.
- the blunt, minimally traumatic tissue implant device used to tunnel the sensor 12 into a subcutaneous region may be a biopsy trocar 90 shown generally in Figure 4.
- the biopsy trocar 90 includes an introducer 92 into which the main body 94 of the trocar 90, having a sharp end 100, and a secondary body 96 of the trocar 90, having a blunt end 98, may be inserted.
- the introducer 92 may be made of plastic while the main body 94 and the secondary body 96 may be made of metal.
- the secondary body 96 having the blunt end 98 may be inserted into the main body 94 having the sharp end 100, and both the secondary body 96 and the main body 94 may be inserted into the introducer 92.
- All three portions of the trocar 90 may then be tunneled into the subcutaneous tissue.
- the sharp end 100 of the main body 94 of the trocar 90 may make an initial incision, while the blunt end 98 of the secondary body 96 may tunnel through the subcutaneous tissue.
- By tunneling through the subcutaneous tissue with the blunt end 98 of the secondary body 96 less damage occurs to the subcutaneous tissue than would occur if the subcutaneous tissue were tunneled with the sharp end 100 of the main body 94, resulting in less bleeding and less trauma to the tissue and the patient.
- the sensor 12 is then guided through the introducer 92 so that the sensing element 22 eventually arrives at its desired location.
- the introducer 92 may then be removed from the body and the connector 18 may then be connected to the implant unit 10. Because the sensing element 22 of the sensor 12 is not located in the vicinity of the main incision that was made to insert the implant unit 10, the difficulties associated with obtaining a signal from the sensing element 22 due to the trauma of the area are avoided. Because the sensing element 22 is located away from the implant unit 10 incision, there is nothing to prevent obtaining a signal from the sensing element 22 in a very short period of time.
- the implant unit 10 is an insulin pump and the sensing element 22 of the sensor 12 is a glucose oxidase enzyme for sensing insulin levels in diabetics
- automated insulin analysis and insulin delivery in a diabetic patient may be feasible within 24 hours of in vivo implantation of the implant unit 10 and the sensor 12.
- a variety of materials may be placed around the implant unit 10 or sensor 12 to promote different characteristics of the foreign body capsule or sensor area.
- the implant unit 10 or sensor 12 may be covered with GORE-TEX or PTFE. Other materials may also be used to cover the implant unit 10 or sensor 12 depending on the nature of the characteristics of the foreign body capsule or area around the sensor 12 desired. In addition, various chemicals may be pumped into the area of the foreign body capsule in order to promote different characteristics of the foreign body capsule, such as, for example, blood vessel growth. .
- the implant unit 10 and the sensor 12 are modular units and may connect to each other via a mechanical interface. Because of the modularity of the implant unit 10 and the sensor 12, the sensor 12 may be removed or replaced without removing the implant unit 10.
- FIGS. 5 A, 5B and 5C Data for sensors used in glucose sensing applications may be seen in FIGS. 5 A, 5B and 5C.
- FIG. 5 A glucose data over a period of several days for a sensor implanted into a foreign body capsule may be seen.
- FIG. 5B glucose data over a period of several days for a sensor implanted into subcutaneous tissue may be seen.
- FIG. 5C glucose data over a period of several days for a sensor implanted into a body cavity such as a peritoneal space may be seen.
- a physiological parameter sensing element may be placed in any medical article or device that has surfaces that contact tissue, blood, or other bodily fluids in the course of their operation, which fluids are subsequently used in patients.
- This may include, for example, extracorporeal devices for use in surgery such as blood oxygenators, blood pumps, tubing used to carry blood and the like which contact blood which is then returned to the patient.
- FIG. 6 shows a blood oxygenator 30.
- Blood oxygenators are well known in the medical field. Usually they are disposable components of so-called “heart-lung machines.” These machines mechanically pump a patient's blood 32 and oxygenate the blood during major surgery such as a heart bypass operation. The oxygenated blood 34 is then returned to the patient.
- the physiological parameter sensing element may be placed in the blood oxygenator 30 in order to detect oxygen or other physiological parameters in the patient's blood.
- the physiological parameter sensing element may be placed in an input line which feeds the patient's blood 32 to the blood oxygenator 30 or an output line that delivers the oxygenated blood 34 to the patient.
- the physiological parameter sensing element may sense a physiological parameter in the blood.
- Other embodiments of the present invention address the problems described above in relation to the placement of a sensor in non-vascular areas of a body. As discussed above, when the sensing element is used in a vascular area of the body, the sensing element senses an homogenous amount of oxygen or other physiological parameter as it flows past the sensing element.
- the amount of a physiological parameter in non-vascular areas of the body may be more heterogeneous.
- the sensing element may sense the physiological parameter through diffusion from, for example, fluid around the sensing element.
- the heterogeneous nature of a physiological parameter in that area may result in varying amounts of the physiological parameter.
- the amount of a physiological parameter sensed may vary depending on the location of the sensing element within that particular area of the body.
- the particular area of the body is the peritoneum and the physiological parameter is oxygen
- the capillaries of the peritoneum are the sources of the oxygen.
- the topology of capillaries within the peritoneum may vary in different areas of the peritoneum.
- the oxygen levels may also vary in different areas of the peritoneum. Therefore, using only one sensing element it may be difficult to accurately determine an "overall amount" of the physiological parameter in the non-vascular areas of the body, i.e., an amount that accurately represents, for example, an average amount or other suitable statistical measure of the physiological parameter in the particular area of the body. This is because the amount of the physiological parameter may vary depending on the location of the sensing element in the particular area of the body.
- another problem results from the fact that the heterogeneous nature of the physiological parameter being sensed by the sensing element may induce noise in the signal obtained from the sensing element.
- sensor lead 40 may include two or more sensing elements.
- one sensing element may be a proximal sensing element 42, i.e., one located closest to an end of the sensor lead 40 that is attached to the implant unit 10.
- the other sensing element may be a distal sensing element 44, i.e., one located closest to an end of the sensor lead 40 furthest away from the point of attachment of the sensor lead 30 to implant unit 10.
- the distance between one sensing element and another sensing element may be approximately 5 or 6 inches.
- the distance between sensing elements may vary depending on the particular application in which the sensing elements are used, as well as the location of the sensing elements.
- the spatial separation of sensing elements 42, 44 in sensor lead 40 is employed in order to sense the physiological parameters at different locations within the environment in which the sensor lead 40 is situated.
- the sensing elements 42, 44 may be situated within the peritoneum and the physiological parameter to be sensed may be oxygen.
- each of the sensing elements may generate a signal representing an amount of oxygen at different spatial points within the peritoneum.
- signals representing sensed amounts of oxygen may be taken from the two or more sensing elements.
- the individual sensed amounts of oxygen may then be used to determine an overall amount of the physiological parameter. This may be done, as an example, through use of an algorithm or algorithms which determine the overall amount based on the individual sensed amounts at the different locations within the environment.
- the algorithm or algorithms may determine the overall amount of the physiological parameter by calculating a statistical measurement of the individual sensed amounts represented by the generated signals.
- the statistical measurement may be, but is not limited to, a maximum amount for the individual sensed amounts, an average amount of the individual sensed amounts, a median of the individual sensed amounts, an arithmetic mean of the individual sensed amounts, or a weighted arithmetic mean of the individual sensed amounts.
- the algorithm may be executed, for example, by a computing element comprising software, hardware, firmware or a combination of software, hardware, and firmware.
- the computing element for executing the algorithm or algorithms may be implemented by electronics within an implant unit associated with the sensing elements 42 and 44, such as the electronics in implant unit 10 described above.
- the sensing elements may be used in or with an extracorporeal device such as a blood oxygenator and the algorithm or algorithms may be executed by a computing element associated with the extracorporeal device or by a dedicated computing element associated with the sensing elements.
- the variance of oxygen levels may induce noise in the individual sensing elements 42, 44 of the sensor lead 40.
- FIG. 8 a graphical representation of glucose data over a period of several days may be seen for sensor lead 40 implanted into the peritoneum. The glucose data is shown for both the proximal sensing element 42 and the distal sensing element 44. The glucose data was obtained by detecting a first and a second signal from the proximal sensing element 42 and the distal sensing element 44, respectively.
- the first and second signals represent, respectively, first and second individual amounts of glucose. As can be seen in FIG. 8, the first and second signals contain a first and a second noise level, respectively.
- FIG. 9 a graphical representation of glucose data over the same period for both the distal and proximal sensing elements is shown.
- the glucose data shown in FIG. 9 is a third signal representing an average amount of glucose calculated using the first and second signals representing individual sensed amounts of glucose. This average amount may be calculated using an algorithm, according to an embodiment of the present invention described above.
- an average noise level of the third signal (a third noise level) is less than that of the first and second noise levels of the first and second signals, according to embodiments of the present invention.
- the noise level of the averaged signal produced by the sensing elements may be reduced, producing a smoother signal.
- the statistical measurement used to obtain the third signal above is an average amount of the individual sensed amounts
- other statistical measurements may be used, including, but not limited to, a maximum amount for the individual sensed amounts, a median of the individual sensed amounts, an arithmetic mean of the individual sensed amounts, and a weighted arithmetic mean of the individual sensed amounts.
- FIG. 7 the sensing elements are shown in a one-dimensional straight line, the invention is not so limited.
- multiple element spatial sensing may be realized using any geometry or array of sensing elements, including two and three- dimensional arrays.
- multiple element spatial sensing may be performed when the sensing elements are used in a vascular area of the body and is not restricted to use in the peritoneum or other non- vascular area.
- digital signal processing may also be used either alone or in combination with a multiple element spatial sensing method according to embodiments of the present invention to reduce the noise level of the signal produced by the sensing elements, producing a smoother signal.
- a digital signal processor may use known noise reduction techniques such as filtering, as well as other signal smoothing techniques.
- the DSP may be located within an implant unit associated with the sensing elements 42 and 44, such as the implant unit 10.
- the DSP may be associated with the extracorporeal device or may be a dedicated DSP associated with the sensing elements.
- more aggressive frequency based filtering may be used either alone or in combination with the multiple element spatial sensing and/or digital signal processing to reduce the noise level.
- the central frequency of the noise may be determined and the filter may be used to cut off the noise at that frequency.
- a single-pole IRR filter is used for this purpose.
- other filters may be used depending on the application. In FIG.
- a graphical representation of unfiltered glucose data over a period of several days may be seen for proximal sensing element 42 of sensor lead 40 implanted into the peritoneum.
- a graphical representation of filtered glucose data may be seen for proximal sensing element 42 over the same period.
- the noise level of the signal produced by proximal sensing element 42 has been reduced by filtering the signal according to embodiments of the present invention.
- FIG. 12 a graphical representation of the unfiltered average of the glucose data over the same period for both the distal and proximal sensing elements is shown.
- FIG. 13 a graphical representation of the filtered average of the glucose data over the same period for both the distal and proximal sensing elements is shown.
- a placement site structure 110 used to structurally engineer a sensor placement site according to an embodiment of the present invention is shown in Figure 14.
- the placement site structure 110 may be viewed as a mechanical "scaffold" within a tissue mass around which forms a vascular bed in close proximity to the sensor.
- a sensor (not shown in Figure 14) may be placed within an interior space 116 of the placement site structure 110, providing easy sensor removal and reinsertion into a non- vascular area of the body.
- the placement site structure 110 may be formed into a variety of shapes to accommodate any of a variety of sensors.
- the placement site structure 110 is formed as a right circular cylinder having an interior space 116.
- the placement site structure 110 may be a tube or a stent.
- an interior diameter of the placement site structure 110 may be 0.010" to 0.030' greater than an outer diameter of the sensor.
- a layer of silicone rubber tubing 112 may surround the body of the placement site structure 110, except in a region of the sensor containing an opening to an enzyme electrode.
- the silicone rubber tubing 112 may provide a barrier for tissue ingress and may also provide direction for tissue growth between the outer surface of the sensor and inner surface of the placement site structure 110. Openings 114 in the placement site structure 110 may also be positioned about 0.60" away from a sensor electrode to facilitate tissue anchoring. Vascularization around the placement site structure 110 may be promoted by coating the silicone rubber tubing 112 with angiogenic factors or endothelial cells. Openings or holes 114 may be provided in the silicone rubber tubing 112 as an additional pathway to the implant site for angiogenic factors or plasmids which encode such factors. The size of the holes 114 may be in the mil or micron range.
- the holes 114 may also provide openings for tissue ingress into the area between the sensor and the interior walls of the placement site structure 110. Hole density and placement may be designed to satisfy both the need for tissue growth in the interior portion of the placement site structure 110 and the need to direct blood vessels feeding the tissue to the openings of the placement site structure 110 closest to the sensor electrodes.
- the opening 114 in the placement site structure 110 near the sensor electrodes may be exposed to an infusion of angiogenic factors, plasmids encoding for angiogenic factors, and endothelial cells. Infusion may be timed to occur at some time after implant which is suitable for the healing of the implant wound to begin.
- Infusion of angiogenic factors, plasmids encoding for angiogenic factors, and endothelial cells to a region close to sensor electrodes may promote vascular growth near the active enzyme of the sensor.
- Angiogenic factors, plasmids encoding for angiogenic factors, and endothelial cells may actually be incorporated within an enzyme matrix to promote blood vessel growth into the enzyme region of the sensor.
- Blood vessel density may be maximized in areas of the placement site structure 110 not covered with a silicone rubber tubing 112. Blood flow rate through any openings in the placement site structure 110 should be sufficient to supply the tissue growing in the interior portion of the placement site structure 110 between the interior walls of the placement site structure 110 and the sensor.
- the size and spacing between anchor openings in the placement site structure 110 and the sensor opening may be optimized to allow sufficient analyte flux to the sensor.
- the sensor itself may be designed to overcome oxygen deficit through its own design or by its design in connection with the design of the placement site structure 110.
- Embodiments of the present invention may be used in a variety of ways. For example, embodiments of the present invention may be used in connection with THERACYTE, INC. products. THERACYTE, INC., develops and manufactures biocompatible medical device implants that deliver therapies for treatment of chronic and/or deficiency diseases, such as, for example, diabetes.
- implants may include biocompatible membranes that induce the development of capillaries close to the membranes, i.e., the implant may be vascularized. Such vascularization promotes a supply of blood to nourish the tissues within the membranes.
- the implant may have a thin fluid layer around a sensor placed inside of the implant or infusion site.
- Current products available from THERACYTE, INC. include 4.5, 20 and 40 microliter size implants.
- embodiments of the present invention can be used in connection with modifications to these products, such as, for example, implants with fewer or greater layers than the implants currently available from THERACYTE, INC.
- Embodiments of the present invention may also be used in connection with reusable and non-reusable implant sites or sensor sites.
- embodiments of the present invention may be used in connection with single or one-time implantations.
- the site housing material may be formed to have an interior cavity with an opening and a conduit that is connected to the opening of the interior tissue ingrowth and vascularization, and yet be free of tissue ingress.
- the site housing material may permit the analyte to pass through the site housing material to the interior cavity, thus permitting measurement by the replaceable analyte sensor.
- the conduit may have a predetermined length to inhibit trauma and encapsulation of tissue occurring at the conduit, which is associated with placing the replaceable analyte sensor in the interior cavity of the site housing, from interfering with the tissue ingrowth and vascularization surrounding the interior cavity of the site housing material.
- embodiments of the present invention may be used in connection with a closed vascularized site that includes a thin layer of fluid around the sensor, or a site that has a thin fluid layer on the interior of the site that is used to transmit an analyte to the sensor from the vascularized site in the body.
- Embodiments of the invention such as those described above are related to U.S.
- Patent #6,368,274 Reusable Analyte Sensor Site and Method of Using The Same, which is hereby incorporated herein by reference. While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that the invention is not limited to the particular embodiments shown and described and that changes and modifications may be made without departing from the spirit and scope of the appended claims.
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Abstract
Description
Claims
Applications Claiming Priority (7)
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US335627P | 2001-10-23 | ||
US10/034,627 US7025760B2 (en) | 2001-09-07 | 2001-12-27 | Method and system for non-vascular sensor implantation |
US34627 | 2001-12-27 | ||
US41429002P | 2002-09-27 | 2002-09-27 | |
US414290P | 2002-09-27 | ||
PCT/US2002/033923 WO2003034902A2 (en) | 2001-10-23 | 2002-10-23 | Method and system for non-vascular sensor implantation |
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JP (1) | JP2005525139A (en) |
AU (1) | AU2002343567A1 (en) |
CA (1) | CA2458966C (en) |
WO (1) | WO2003034902A2 (en) |
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Also Published As
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WO2003034902A3 (en) | 2004-03-11 |
WO2003034902A2 (en) | 2003-05-01 |
AU2002343567A1 (en) | 2003-05-06 |
CA2458966A1 (en) | 2003-05-01 |
CA2458966C (en) | 2013-02-26 |
JP2005525139A (en) | 2005-08-25 |
EP1438029A4 (en) | 2009-01-14 |
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