EP1417329A4 - Methods for generating antibiotic resistant microbes and novel antibiotics - Google Patents

Methods for generating antibiotic resistant microbes and novel antibiotics

Info

Publication number
EP1417329A4
EP1417329A4 EP01963754A EP01963754A EP1417329A4 EP 1417329 A4 EP1417329 A4 EP 1417329A4 EP 01963754 A EP01963754 A EP 01963754A EP 01963754 A EP01963754 A EP 01963754A EP 1417329 A4 EP1417329 A4 EP 1417329A4
Authority
EP
European Patent Office
Prior art keywords
methods
antibiotic resistant
novel antibiotics
resistant microbes
generating antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01963754A
Other languages
German (de)
French (fr)
Other versions
EP1417329A1 (en
Inventor
Nicholas C Nicolaides
Philip M Sass
Luigi Grasso
J Bradford Kline
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphotek Inc
Original Assignee
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphotek Inc filed Critical Morphotek Inc
Publication of EP1417329A1 publication Critical patent/EP1417329A1/en
Publication of EP1417329A4 publication Critical patent/EP1417329A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C12Q1/20—Testing for antimicrobial activity of a material using multifield media
EP01963754A 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics Withdrawn EP1417329A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/023888 WO2003012130A1 (en) 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics

Publications (2)

Publication Number Publication Date
EP1417329A1 EP1417329A1 (en) 2004-05-12
EP1417329A4 true EP1417329A4 (en) 2005-05-11

Family

ID=21742739

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01963754A Withdrawn EP1417329A4 (en) 2001-07-25 2001-07-25 Methods for generating antibiotic resistant microbes and novel antibiotics

Country Status (3)

Country Link
EP (1) EP1417329A4 (en)
CA (1) CA2455686A1 (en)
WO (1) WO2003012130A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60329526D1 (en) 2002-11-15 2009-11-12 Morphotek Inc METHOD OF GENERATING HIGH ANTIBODY PRODUCTION OF HYBRIDOMAS RESULTING FROM IN VITRO IMMUNIZATION
TWI778025B (en) * 2017-02-24 2022-09-21 碁米庫斯生物科技股份有限公司 Antibiotic testing and screening system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
WO2002054856A1 (en) * 2001-01-15 2002-07-18 Morphotek Inc. Chemical inhibitors of mismatch repair

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY103919A (en) * 1988-03-30 1993-10-30 Kao Corp Mutant resistant to cell membrane synthesis inhibitor and process for preparing the same.
DE19717346C2 (en) * 1997-04-24 1999-05-20 Max Planck Gesellschaft DNA probes, methods and kit for identifying antibiotic resistant bacterial strains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
WO2002054856A1 (en) * 2001-01-15 2002-07-18 Morphotek Inc. Chemical inhibitors of mismatch repair

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DRUMMOND ET AL.: "DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutS alpha /hMutS beta ratio and reduces the efficiency of base-base mismatch repair.", PROC. NATL. ACAD. SCI. USA, vol. 94, July 1997 (1997-07-01), pages 10144 - 10149, XP002320277 *
DRUMMOND J T ET AL: "CISPLATIN AND ADRIAMYCIN RESISTANCE ARE ASSOCIATED WITH MUTL-ALPHA AND MISMATCH REPAIR DEFICIENCY IN AN OVARIAN TUMOR CELL LINE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 33, 16 August 1996 (1996-08-16), pages 19645 - 19648, XP002939396, ISSN: 0021-9258 *
PETER KARRAN: "Mechanisms of tolerance to DNA damaging therapeutic drugs", CARCINOGENESIS, vol. 22, no. 12, December 2001 (2001-12-01), pages 1931 - 1937, XP002320360 *
See also references of WO03012130A1 *

Also Published As

Publication number Publication date
CA2455686A1 (en) 2003-02-13
EP1417329A1 (en) 2004-05-12
WO2003012130A1 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
IL163749A0 (en) Novel florfenicol-type antibiotics
EP1438080A4 (en) Antibiotic calcium phosphate coating
EP1482957A4 (en) Antibiotic conjugates
AU2001257490A1 (en) Improved beta-lactam antibiotics
AU2002355284A8 (en) Direct-fed microbial
IL158971A0 (en) Identifying micro-organisms
GB0011186D0 (en) Modification of bacteria
AU2002367969A8 (en) Toxin-phage bacteriocide antibiotic and uses thereof
AU2001285693A1 (en) Bio-reactor
EP1487414A4 (en) Antibiotic composition
AU2002359761A8 (en) Antibiotic compounds
AU7272900A (en) Phage resistant bacteria
AU2003267948A1 (en) Aminoglycoside antibiotics and methods of using same
EP1417329A4 (en) Methods for generating antibiotic resistant microbes and novel antibiotics
AU2001284679A1 (en) Methods for generating antibiotic resistant microbes and novel antibiotics
GB0220235D0 (en) Glycopeptide antibiotics
GB0104140D0 (en) Timed-release cryptography
AU2002303498A1 (en) Antibiotics aa-896
GB0103315D0 (en) Antibiotics
IL146725A0 (en) Antibiotic spray
GB0028570D0 (en) Bacterial gene
AU2002303468A1 (en) Antibiotics aa-896
AU2003284577A1 (en) Novel antibiotic muraminomicin
GB9929744D0 (en) Modifying micro-organisms
AU2002313668A1 (en) Launcher for compressible materials and associated process

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040209

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20050401

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060522