EP1210138A4 - Controlled delivery of bisphosphonates - Google Patents

Controlled delivery of bisphosphonates

Info

Publication number: EP1210138A4
Authority: EP; European Patent Office
Prior art keywords: bisphosphonates; controlled delivery; delivery; controlled
Prior art date: 1999-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00928260A

Other languages

German (de)

French (fr)

Other versions

EP1210138A1 (en

Inventor

Petr Kuzma

Agis Kydonieus

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Valera Pharmaceuticals Inc

Original Assignee

Valera Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-22

Filing date

2000-04-19

Publication date

2003-05-07

2000-04-19 Application filed by Valera Pharmaceuticals Inc filed Critical Valera Pharmaceuticals Inc

2002-06-05 Publication of EP1210138A1 publication Critical patent/EP1210138A1/en

2003-05-07 Publication of EP1210138A4 publication Critical patent/EP1210138A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes

EP00928260A 1999-04-22 2000-04-19 Controlled delivery of bisphosphonates Withdrawn EP1210138A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13072899P	1999-04-22	1999-04-22
US130728P		1999-04-22
PCT/US2000/010696 WO2000064516A1 (en)	1999-04-22	2000-04-19	Controlled delivery of bisphosphonates

Publications (2)

Publication Number	Publication Date
EP1210138A1 EP1210138A1 (en)	2002-06-05
EP1210138A4 true EP1210138A4 (en)	2003-05-07

Family

ID=22446043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00928260A Withdrawn EP1210138A4 (en)	1999-04-22	2000-04-19	Controlled delivery of bisphosphonates

Country Status (4)

Country	Link
EP (1)	EP1210138A4 (en)
AU (1)	AU4652100A (en)
CA (1)	CA2370769A1 (en)
WO (1)	WO2000064516A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6984400B2 (en)	1998-07-14	2006-01-10	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of treating restenosis using bisphosphonate nanoparticles
IL125336A0 (en)	1998-07-14	1999-03-12	Yissum Res Dev Co	Compositions for inhibition and treatment of restinosis
US7008645B2 (en)	1998-07-14	2006-03-07	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Method of inhibiting restenosis using bisphosphonates
FR2803521B1 (en) *	2000-01-12	2002-10-25	Ceva Sante Animale	USE OF TILUDRONIC ACID AND ITS DERIVATIVES IN POULTRY FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR PREVENTING AND TREATING OSTEOPOROSIS
US7829074B2 (en)	2001-10-18	2010-11-09	Nektar Therapeutics	Hydroxypatite-targeting poly(ethylene glycol) and related polymers
CA2438208A1 (en) *	2001-02-07	2002-08-15	Durect Corporation	Devices and methods for management of bone density
KR20020080018A (en) *	2001-04-10	2002-10-23	한국화학연구원	A controlled/sustained implant delivery containing bisphosphonate
US10517883B2 (en)	2003-06-27	2019-12-31	Zuli Holdings Ltd.	Method of treating acute myocardial infarction
FI20031120A0 (en) *	2003-07-31	2003-07-31	Bci Bioabsorbable Concepts Ltd	Multifunctional implant device
ES2561463T3 (en) *	2003-08-21	2016-02-26	Addbio Ab	Implant device coated with bisphosphonate and method for it
WO2010111627A1 (en) *	2009-03-26	2010-09-30	Psivida Us, Inc.	Implantable formulations of bisphosphonic acids
US20160016982A1 (en)	2009-07-31	2016-01-21	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
US9169279B2 (en)	2009-07-31	2015-10-27	Thar Pharmaceuticals, Inc.	Crystallization method and bioavailability
NO2459176T3 (en)	2009-07-31	2018-02-24
WO2011103307A1 (en) *	2010-02-17	2011-08-25	Georgia Tech Research Corporation	Compositions and methods for modifying in vivo calcification of hydrogels
WO2012071517A2 (en)	2010-11-24	2012-05-31	Thar Pharmaceuticals, Inc.	Novel crystalline forms
US9993427B2 (en)	2013-03-14	2018-06-12	Biorest Ltd.	Liposome formulation and manufacture
JO3394B1 (en) *	2014-07-04	2019-10-20	Osteo Pharma B V	Compositions and products for use in the treatment of bone fractures and defects
US10195218B2 (en)	2016-05-31	2019-02-05	Grunenthal Gmbh	Crystallization method and bioavailability
US20210205459A1 (en) *	2018-06-01	2021-07-08	The University Of North Carolina At Chapel Hill	Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3d printing bioink

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4753652A (en) *	1984-05-04	1988-06-28	Children's Medical Center Corporation	Biomaterial implants which resist calcification
US5338731A (en) *	1989-08-20	1994-08-16	Yissum, Research Development Company Of The Hebrew University Of Jerusalem	Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same
JPH08141067A (en) *	1994-11-16	1996-06-04	Olympus Optical Co Ltd	Vital implantation member
US5733564A (en) *	1993-04-14	1998-03-31	Leiras Oy	Method of treating endo-osteal materials with a bisphosphonate solution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2151240A1 (en) *	1992-12-23	1994-07-07	Donna T. Whiteford	Biophosphonate/estrogen therapy for treating and preventing bone loss
US5646134A (en) *	1994-04-21	1997-07-08	Merck & Co., Inc.	Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
AU5973496A (en) *	1995-06-06	1996-12-24	Merck & Co., Inc.	Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
US5898038A (en) *	1996-03-19	1999-04-27	Board Of Regents, The University Of Texas System	Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
GB2324726A (en) *	1997-05-01	1998-11-04	Merck & Co Inc	Combination Therapy for the Treatment of Osteoporosis

2000
- 2000-04-19 EP EP00928260A patent/EP1210138A4/en not_active Withdrawn
- 2000-04-19 CA CA002370769A patent/CA2370769A1/en not_active Abandoned
- 2000-04-19 AU AU46521/00A patent/AU4652100A/en not_active Abandoned
- 2000-04-19 WO PCT/US2000/010696 patent/WO2000064516A1/en not_active Application Discontinuation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4753652A (en) *	1984-05-04	1988-06-28	Children's Medical Center Corporation	Biomaterial implants which resist calcification
US5338731A (en) *	1989-08-20	1994-08-16	Yissum, Research Development Company Of The Hebrew University Of Jerusalem	Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same
US5733564A (en) *	1993-04-14	1998-03-31	Leiras Oy	Method of treating endo-osteal materials with a bisphosphonate solution
JPH08141067A (en) *	1994-11-16	1996-06-04	Olympus Optical Co Ltd	Vital implantation member

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199632, Derwent World Patents Index; Class B07, AN 1996-316679, XP002233498 *
DENISSEN H ET AL: "ALVEOLAR BONE RESPONSE TO SUBMERGED BISPHOSPHONATE-COMPLEXED HYDROXYAPATITE IMPLANTS", JOURNAL OF PERIODONTOLOGY, AMERICAN ACADEMY OF PERIODONTOLOGY, CHICAGO, IL, US, vol. 71, no. 2, February 2000 (2000-02-01), pages 279 - 286, XP008010275, ISSN: 0022-3492 *
GOLOMB G ET AL: "CHARACTERIZATION AND ANTICALCIFICATION EFFECTS OF IMPLANTABLE POLYURETHANE MATRICES CONTAINING AMORPHOUS DISPERSION OF BISPHOSPHONIC ACID", CLINICAL MATERIALS, ELSEVIER, GB, vol. 8, no. 1/2, 1991, pages 33 - 42, XP002063577, ISSN: 0267-6605 *
GOLOMB G ET AL: "CONTROLLED RELEASE OF DIPHOSPHONATE TO INHIBIT BIOPROSTHETIC HEART VALVE CALCIFICATION: DOSE-RESPONSE AND MECHANISTIC STUDIES", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 4, no. 3, 1986, pages 181 - 194, XP000653819, ISSN: 0168-3659 *
JOHNSTON T P ET AL: "SITE-SPECIFIC DELIVERY OF ETHANEHYDROXY DIPHOSPHONATE FROM REFILLABLE POLYURETHANE RESERVOIRS TO INHIBIT BIOPROSTHETIC TISSUE CALCIFICATION", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 25, no. 3, 1 June 1993 (1993-06-01), pages 227 - 240, XP000369909, ISSN: 0168-3659 *
PATASHNIK S ET AL: "PREPARATION AND EVALUATION OF CHITOSAN MICROSPHERES CONTAINING BISPHOSPHONATES", JOURNAL OF DRUG TARGETING, HARWOOD ACADEMIC PUBLISHERS GMBH, DE, vol. 4, no. 6, 1997, pages 371 - 380, XP000874480, ISSN: 1061-186X *
SABOKBAR A ET AL: "Bisphosphonates in bone cement inhibit PMMA particle induced bone resorption", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 57, no. 10, October 1998 (1998-10-01), pages 614 - 618, XP002953301, ISSN: 0003-4967 *
See also references of WO0064516A1 *
VYAVAHARE N R ET AL: "Synergism of calcium-ethanehydroxybisphosphonate (CaEHBP) and FeCl3: controlled release polymers for preventing calcification of bioprosthetic aortic wall", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 34, no. 2, 1 May 1995 (1995-05-01), pages 97 - 108, XP004037508, ISSN: 0168-3659 *

Also Published As

Publication number	Publication date
CA2370769A1 (en)	2000-11-02
AU4652100A (en)	2000-11-10
WO2000064516A1 (en)	2000-11-02
EP1210138A1 (en)	2002-06-05

Legal Events

Date	Code	Title	Description
2002-04-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2002-06-05	17P	Request for examination filed	Effective date: 20011217
2002-06-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-06-05	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-09-25	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HYDRO MED SCIENCES, INC.,
2003-05-02	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61K 9/00 B Ipc: 7A 61L 27/12 B Ipc: 7A 61K 47/32 B Ipc: 7A 61K 31/66 A Ipc: 7A 61L 27/54 B
2003-05-07	A4	Supplementary search report drawn up and despatched	Effective date: 20030320
2003-06-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2003-07-23	18W	Application withdrawn	Effective date: 20030526

Publication	Publication Date	Title
EP1210138A4 (en)	2003-05-07	Controlled delivery of bisphosphonates
IL142807A0 (en)	2002-03-10	Controlled delivery of active agents
IL137650A0 (en)	2001-10-31	Drug delivery devices
AU7892001A (en)	2002-02-13	Vaginal delivery of bisphosphonates
IL149663A0 (en)	2002-11-10	Devices for the delivery of drugs having antiprogestinic properties
HK1079718A1 (en)	2006-04-13	Intracardiac drug delivery
GB0003427D0 (en)	2000-04-05	Medical nebulizer
GB2335583B (en)	2002-05-29	Controlling delivery of radiotherapy
GB9900222D0 (en)	1999-02-24	Therapeutic compounds
GB2352314B (en)	2003-11-26	Delivery system
GB0011066D0 (en)	2000-06-28	Delivery system
GB0025039D0 (en)	2000-11-29	Nebuliser
GB9930160D0 (en)	2000-02-09	Drug delivery
GB9914960D0 (en)	1999-08-25	Delivery system
GB9927525D0 (en)	2000-01-19	Delivery of substances
GB9804768D0 (en)	1998-04-29	Drug delivery
GB9904304D0 (en)	1999-04-21	Drug delivery
GB9923578D0 (en)	1999-12-08	Nebulizers
GB9913060D0 (en)	1999-08-04	Aromatherapy
GB9905134D0 (en)	1999-04-28	Medicament delivery system
GB9917470D0 (en)	1999-09-29	Medicament delivery system
GB9923273D0 (en)	1999-12-08	Medicament delivery system
GB9916886D0 (en)	1999-09-22	Therapeutic compounds
GB9903090D0 (en)	1999-03-31	Therapeutic compounds
GB9914952D0 (en)	1999-08-25	Therapeutic compounds