DE69909519T2 - Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe - Google Patents

Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe

Info

Publication number
DE69909519T2
DE69909519T2 DE69909519T DE69909519T DE69909519T2 DE 69909519 T2 DE69909519 T2 DE 69909519T2 DE 69909519 T DE69909519 T DE 69909519T DE 69909519 T DE69909519 T DE 69909519T DE 69909519 T2 DE69909519 T2 DE 69909519T2
Authority
DE
Germany
Prior art keywords
biologically active
block
biodegradable
active substances
delayed release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69909519T
Other languages
English (en)
Other versions
DE69909519D1 (de
Inventor
Subodh Shah
Weiguo Dai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority claimed from PCT/US1999/029401 external-priority patent/WO2000038651A1/en
Application granted granted Critical
Publication of DE69909519D1 publication Critical patent/DE69909519D1/de
Publication of DE69909519T2 publication Critical patent/DE69909519T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
DE69909519T 1998-12-23 1999-12-10 Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe Expired - Fee Related DE69909519T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/221,178 US6451346B1 (en) 1998-12-23 1998-12-23 Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
PCT/US1999/029401 WO2000038651A1 (en) 1998-12-23 1999-12-10 BIODEGRADABLE pH/THERMOSENSITIVE HYDROGELS FOR SUSTAINED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS

Publications (2)

Publication Number Publication Date
DE69909519D1 DE69909519D1 (de) 2003-08-14
DE69909519T2 true DE69909519T2 (de) 2003-12-24

Family

ID=22826693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909519T Expired - Fee Related DE69909519T2 (de) 1998-12-23 1999-12-10 Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe

Country Status (9)

Country Link
US (2) US6451346B1 (de)
JP (1) JP2002533377A (de)
AT (1) ATE244556T1 (de)
AU (1) AU769347B2 (de)
CA (1) CA2355657C (de)
DE (1) DE69909519T2 (de)
ES (1) ES2197711T3 (de)
PT (1) PT1143929E (de)
TW (1) TWI250028B (de)

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ES2197711T3 (es) 2004-01-01
CA2355657C (en) 2005-05-03
US20030099709A1 (en) 2003-05-29
TWI250028B (en) 2006-03-01
US6451346B1 (en) 2002-09-17
AU2708100A (en) 2000-07-31
DE69909519D1 (de) 2003-08-14
CA2355657A1 (en) 2000-07-06
JP2002533377A (ja) 2002-10-08
AU769347B2 (en) 2004-01-22
ATE244556T1 (de) 2003-07-15

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