DE69900714D1 - Verfahren und vorrichtung zur laminaren strömung an einer sensoroberfläche - Google Patents

Verfahren und vorrichtung zur laminaren strömung an einer sensoroberfläche

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Publication number
DE69900714D1
DE69900714D1 DE69900714T DE69900714T DE69900714D1 DE 69900714 D1 DE69900714 D1 DE 69900714D1 DE 69900714 T DE69900714 T DE 69900714T DE 69900714 T DE69900714 T DE 69900714T DE 69900714 D1 DE69900714 D1 DE 69900714D1
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DE
Germany
Prior art keywords
sensor surface
laminary flow
laminary
flow
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69900714T
Other languages
English (en)
Other versions
DE69900714T2 (de
Inventor
Magnus Malmqvist
Hakan Roos
Stefan Sjoelander
Mattias Tidare
Hakan Sjoedin
Ralph Stalberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Biacore AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore AB filed Critical Biacore AB
Application granted granted Critical
Publication of DE69900714D1 publication Critical patent/DE69900714D1/de
Publication of DE69900714T2 publication Critical patent/DE69900714T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
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    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00675—In-situ synthesis on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
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    • G01N2021/058—Flat flow cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/01—Micromixers: continuous laminar flow with laminar boundary mixing in the linear direction parallel to the fluid propagation with or without conduit geometry influences from the pathway
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/03—Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69900714T 1998-01-20 1999-01-19 Verfahren und vorrichtung zur laminaren strömung an einer sensoroberfläche Expired - Lifetime DE69900714T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/009,139 US6200814B1 (en) 1998-01-20 1998-01-20 Method and device for laminar flow on a sensing surface
PCT/SE1999/000063 WO1999036766A1 (en) 1998-01-20 1999-01-19 Method and device for laminar flow on a sensing surface

Publications (2)

Publication Number Publication Date
DE69900714D1 true DE69900714D1 (de) 2002-02-21
DE69900714T2 DE69900714T2 (de) 2002-06-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69900714T Expired - Lifetime DE69900714T2 (de) 1998-01-20 1999-01-19 Verfahren und vorrichtung zur laminaren strömung an einer sensoroberfläche

Country Status (5)

Country Link
US (6) US6200814B1 (de)
EP (1) EP1021703B1 (de)
JP (1) JP4340766B2 (de)
DE (1) DE69900714T2 (de)
WO (1) WO1999036766A1 (de)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69737883T2 (de) 1996-04-25 2008-03-06 Bioarray Solutions Ltd. Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
US6200814B1 (en) * 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
US6937341B1 (en) 1998-09-29 2005-08-30 J. A. Woollam Co. Inc. System and method enabling simultaneous investigation of sample with two beams of electromagnetic radiation
EP1117991A4 (de) 1998-10-02 2005-04-27 California Inst Of Techn Organische leitende sensoren, sensormatrix und verfahren zu ihrer gebrauch
FR2790092B1 (fr) * 1999-02-24 2001-03-30 Commissariat Energie Atomique Procede de determination d'un analyte present dans une solution
US7122152B2 (en) * 1999-05-10 2006-10-17 University Of Florida Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids
EP1192454B1 (de) 1999-05-10 2006-03-01 California Institute of Technology Verwendung eines räumlich-zeitlichen reaktionsverhaltens in sensor-arrays zur detektion von analyten in fluiden
US6631333B1 (en) * 1999-05-10 2003-10-07 California Institute Of Technology Methods for remote characterization of an odor
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
JP4684507B2 (ja) 1999-07-05 2011-05-18 ノバルティス アーゲー センサープラットホームを使用する方法
WO2001013096A1 (de) * 1999-08-13 2001-02-22 Zeptosens Ag Vorrichtung und verfahren zur multianalytbestimmung
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6890715B1 (en) * 1999-08-18 2005-05-10 The California Institute Of Technology Sensors of conducting and insulating composites
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US7349092B1 (en) 2000-02-22 2008-03-25 J.A. Woollam Co., Inc System for reducing stress induced effects during determination of fluid optical constants
EP1281047A4 (de) * 2000-04-24 2004-03-24 Nathan S Lewis Raumzeitliche und geometrische optimierung von sensor-arrays zur erkennung von analyten in fluiden
JP4744778B2 (ja) 2000-06-21 2011-08-10 バイオアレイ ソルーションズ リミテッド 特定のランダム粒子アレイを適用した複数の被検体分子の分析方法
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20010055546A1 (en) * 2000-06-23 2001-12-27 Weigl Bernhard H. Method and apparatus for controlling fluid flow rate in a microfluidic circuit
GB0016247D0 (en) * 2000-06-30 2000-08-23 Torsana Biosensor Diagnostics Flow cell assemblies and methods of spatially directed interaction between liquids and solid surfaces
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
SE0100889D0 (sv) 2001-03-14 2001-03-14 Biacore Ab Method and apparatus for attenuated total reflection spectrosopy
SE0100875D0 (sv) * 2001-03-14 2001-03-14 Biacore Ab Method of preparing supported lipid film membranes and use thereof
US7179659B2 (en) * 2001-04-02 2007-02-20 Agilent Technologies, Inc. Sensor surfaces for detecting analytes and methods of use
AU2002258702A1 (en) * 2001-04-02 2002-10-15 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
US7314718B1 (en) * 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002345465B2 (en) * 2001-06-29 2007-04-26 Ge Healthcare Bio-Sciences Ab Flow cell method
SE0102331D0 (sv) * 2001-06-29 2001-06-29 Biacore Ab Flow cell method
WO2003014711A1 (fr) * 2001-08-07 2003-02-20 Mitsubishi Chemical Corporation Puce de detection a resonance de plasmon de surface et procede et dispositif d'analyse d'echantillon utilisant cette puce
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US20040028559A1 (en) * 2001-11-06 2004-02-12 Peter Schuck Sample delivery system with laminar mixing for microvolume biosensing
US20030157586A1 (en) * 2002-02-21 2003-08-21 Martin Bonde Device and method for conducting cellular assays using multiple fluid flow
US7560267B2 (en) * 2002-03-18 2009-07-14 City University Of Hong Kong Apparatus and methods for on-chip monitoring of cellular reactions
US7112444B2 (en) * 2002-04-24 2006-09-26 Wisconsin Alumni Research Foundation Method of performing gradient-based assays in a microfluidic device
US20060127278A1 (en) * 2002-04-26 2006-06-15 Gast Alice P System and method of measuring molecular interactions
DE10222334A1 (de) * 2002-05-18 2003-12-04 Leica Microsystems Vorrichtung zum Einbringen einer Probe in ein Durchfluss-Analysensystem
WO2003102580A1 (en) 2002-05-31 2003-12-11 Biacore Ab Method of coupling binding agents to a substrate surface
AU2003276870A1 (en) * 2002-09-07 2004-03-29 Lightwave Bioapplications Bioanalysis systems including optical integrated circuit
JP2004113874A (ja) * 2002-09-24 2004-04-15 National Institute Of Advanced Industrial & Technology マイクロ流路利用反応方法
AU2003287236A1 (en) * 2002-10-31 2004-06-07 Luna Innovations, Inc. Fiber-optic flow cell and method relating thereto
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20050150778A1 (en) * 2002-11-18 2005-07-14 Lewis Nathan S. Use of basic polymers in carbon black composite vapor detectors to obtain enhanced sensitivity and classification performance for volatile fatty acids
EP1594694A4 (de) 2002-12-30 2010-01-20 Univ California Verfahren und vorrichtung zum nachweis und zur analyse von krankheitserregern
US7655477B1 (en) * 2003-02-26 2010-02-02 Science Applications International Corporation System and method for the separation of analytes
ATE510605T1 (de) * 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
NZ580449A (en) * 2003-09-11 2011-06-30 Theranos Inc Ingestible medical device with biocompatible polymer coating, device with microarray to interact with disease marker
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
NZ546072A (en) 2003-09-22 2009-08-28 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
EP1694859B1 (de) 2003-10-29 2015-01-07 Bioarray Solutions Ltd Multiplex-nukleinsäureanalyse mittels fragmentierung doppelsträngiger dna
JP4341372B2 (ja) * 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 液体の混合方法および混合装置ならびに混合システム
US7396512B2 (en) * 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
EP1682261B1 (de) * 2003-11-12 2012-08-15 BIO-RAD Haifa Ltd. Verfahren zur durchführung mehrerer bindungsreaktionen in arrayformat
WO2005049582A1 (en) * 2003-11-14 2005-06-02 Auspex Pharmaceuticals, Inc. Method of preparation of novel nucleoside analogs and uses
SE0303319D0 (sv) 2003-12-10 2003-12-10 Biacore Ab Sample flow positioning method and analytical system using the method
JP4870571B2 (ja) * 2003-12-10 2012-02-08 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ サンプルの流れの位置決め法及び該方法を用いた分析システム
JP4632400B2 (ja) * 2003-12-16 2011-02-16 キヤノン株式会社 細胞培養用基板、その製造方法、それを用いた細胞スクリーニング法
GB0329220D0 (en) * 2003-12-17 2004-01-21 Inverness Medical Switzerland System
WO2005086703A2 (en) * 2004-03-05 2005-09-22 Creatv Microtech, Inc. Flow-through chemical and biological sensor
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
WO2006047591A2 (en) * 2004-10-25 2006-05-04 University Of Washington Rapid microfluidic assay for analyte interactions
US7285420B2 (en) * 2004-11-18 2007-10-23 Corning Incorporated System and method for self-referencing a sensor in a micron-sized deep flow chamber
DE102005018337A1 (de) * 2005-04-20 2006-11-02 Micronas Gmbh Mikrooptisches Detektionssystem und Verfahren zur Bestimmung temperaturabhängiger Parameter von Analyten
CA2505657A1 (en) * 2005-04-28 2006-10-28 York University Method for mixing inside a capillary and device for achieving same
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
KR101762424B1 (ko) * 2005-05-09 2017-07-28 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070042406A1 (en) * 2005-07-18 2007-02-22 U.S. Genomics, Inc. Diffusion mediated clean-up of a target carrier fluid
JP5184353B2 (ja) * 2005-07-20 2013-04-17 コーニング インコーポレイテッド ラベルフリーハイスループット生体分子スクリーニングシステム及び方法
WO2007024485A2 (en) * 2005-08-11 2007-03-01 Eksigent Technologies, Llc Microfluidic reduction of diffusion and complience effect in a fluid mixing region
DOP2006000277A (es) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Anticuerpos anti mn y métodos para su utilización
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
EP1979079A4 (de) 2006-02-03 2012-11-28 Integenx Inc Mikrofluidische vorrichtungen
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
EP2012923A1 (de) * 2006-04-07 2009-01-14 Corning Incorporated Geschlossene durchflussmikroplatte sowie verfahren zu ihrer verwendung und herstellung
US8974748B2 (en) * 2007-04-05 2015-03-10 Corning Incorporated Dual inlet microchannel device and method for using same
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
CN101534917A (zh) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 采用萃取流体排出流过滤的微流无膜交换系统和方法
WO2008005292A1 (en) * 2006-06-30 2008-01-10 Corning Incorporated Fluid handling system for flow-through assay
US8263415B2 (en) * 2006-09-14 2012-09-11 Ge Healthcare Bio-Sciences Ab Method of determining analyte concentration
US7976217B2 (en) * 2006-09-15 2011-07-12 Corning Incorporated Screening system and method for analyzing a plurality of biosensors
WO2008052138A2 (en) 2006-10-25 2008-05-02 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated dna analysis system using same
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008085991A2 (en) 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
JP4767196B2 (ja) * 2007-02-21 2011-09-07 シャープ株式会社 流路反応方法および流路反応装置
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
DE102007012866A1 (de) 2007-03-09 2008-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Flusskanalsystem und Verfahren zum Anbinden von Analyten an Liganden
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8298496B2 (en) * 2007-07-23 2012-10-30 Flir Systems, Inc. Fluidic configuration for flow injection analysis
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
DE102007038777A1 (de) * 2007-08-10 2009-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Zellkulturmesssystem und Verfahren für vergleichende Untersuchungen an Zellkulturen
US8354280B2 (en) * 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
EP2238165B1 (de) 2008-01-07 2017-07-05 Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Anti-hiv-domäne-antikörper sowie verfahren zu ihrer herstellung und verwendung
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
US8397762B2 (en) * 2008-02-04 2013-03-19 Bioscale, Inc. Fluidic system with improved flow characteristics
MX2010008591A (es) 2008-02-04 2010-08-30 Univ Columbia Dispositivos, sistemas y metodos de separacion de fluidos.
GB0802084D0 (en) * 2008-02-05 2008-03-12 Univ Dublin City Microfluidic device for assessing cell surface interactions
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
CN102341691A (zh) 2008-12-31 2012-02-01 尹特根埃克斯有限公司 具有微流体芯片的仪器
WO2010141326A1 (en) 2009-06-02 2010-12-09 Integenx Inc. Fluidic devices with diaphragm valves
RU2559541C2 (ru) 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
NZ599873A (en) 2009-10-19 2014-09-26 Theranos Inc Integrated health data capture and analysis system
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
EP2524230A4 (de) * 2010-01-13 2013-07-24 Nomadics Inc In-situ-verdünnungsverfahren und system zur messung molekularer und chemischer interaktionen
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8748191B2 (en) * 2010-08-02 2014-06-10 Ecolab Usa Inc. Stop-flow analytical systems and methods
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
US20130295587A1 (en) * 2011-01-24 2013-11-07 Ge Healthcare Bio-Sciences Ab Method of coupling binding agents to a substrate surface
JP5283729B2 (ja) * 2011-04-28 2013-09-04 シャープ株式会社 流路反応方法および流路反応装置
JP6145096B2 (ja) 2011-09-28 2017-06-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面プラズモン共鳴バイオセンサシステム
US9958438B2 (en) 2011-09-30 2018-05-01 Ge Healthcare Bio-Sciences Ab Multi-channel flowcell
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US8795605B2 (en) 2012-01-12 2014-08-05 Fred C. Senftleber Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths
US9632026B2 (en) 2012-01-23 2017-04-25 Flir Systems, Inc. Optical biosensor referencing method
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
EP2859325A2 (de) 2012-06-10 2015-04-15 Bio-Rad Laboratories, Inc. Optisches detektionssystem für flüssigkeitsproben
WO2014003689A1 (en) * 2012-06-28 2014-01-03 Nanyang Technological University Detection device and method for detection of particles
KR20140021899A (ko) * 2012-08-13 2014-02-21 삼성전자주식회사 컨텐츠를 이동시키기 위한 방법 및 그 전자 장치
US9990464B1 (en) 2012-10-09 2018-06-05 Pall Corporation Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method
CN102886236B (zh) * 2012-10-31 2014-06-04 厦门大学 一种纳米尺度的微通道内流体的驱动方法
CN103308426B (zh) * 2013-05-20 2015-12-09 中南大学 液体分子扩散系数的微流控测试方法
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US9377400B2 (en) 2014-03-31 2016-06-28 Redshift Systems Corporation Motion modulation fluidic analyzer system
EP3123148B1 (de) 2014-03-31 2020-05-27 Redshift Systems Corporation Flüssigkeitsanalysegerät mit modulation für flüssigkeiten und gase
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
EP3209410A4 (de) 2014-10-22 2018-05-02 IntegenX Inc. Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben
WO2017045703A1 (en) * 2015-09-15 2017-03-23 Siemens Healthcare Gmbh A technique for focusing a sample in a flow
US10334967B2 (en) 2016-07-25 2019-07-02 Retail Space Solutions Llc Merchandiser and methods relating to same
EP3857199A4 (de) * 2018-09-28 2022-09-07 Nicoya Lifesciences, Inc. Plasmonenresonanzsystem, instrument und vorrichtung zur messung von molekularen wechselwirkungen
DE102020107645A1 (de) * 2020-03-19 2021-09-23 Bruker Daltonics GmbH & Co. KG Betrieb einer Mikrofluidik-Vorrichtung bei der Analyse von Probesubstanzen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK150802C (da) * 1974-09-16 1988-02-01 Bifok Ab Fremgangsmaade og apparat til kontinuerlig hoejhastighedsanalyse af en vaeskeproeve i en baererstroem
DE2521236C3 (de) * 1975-05-10 1978-12-14 Hildegard Dr. 4400 Muenster Goehde Geb. Kuhl Einrichtung zum Zählen und Messen von in einer Flüssigkeit suspendierten Teilchen
NL8700851A (nl) 1987-04-10 1988-11-01 Tno Werkwijze en inrichting voor het detecteren van zeer lage concentraties van een in een meetmedium aanwezige chemische component onder toepassing van oppervlakte-plasmonresonantie en elektrochemisch gestimuleerde adsorptie.
CA1321488C (en) 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE462408B (sv) 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
DE4024476C1 (de) 1990-08-02 1992-02-27 Boehringer Mannheim Gmbh, 6800 Mannheim, De
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
DE69429262T2 (de) 1993-05-18 2002-07-25 Univ Utah Res Found Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
DE4411268C2 (de) * 1994-03-31 2001-02-01 Danfoss As Analyseverfahren und Analysevorrichtung
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
SE9403245D0 (sv) 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
EP1890130A3 (de) 1995-05-12 2008-02-27 Novartis AG Sensorenplattform zur parallelen Erkennung mehrerer Analyte mittels sehr schwach leuchtender Lumineszenzen
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
AU6354796A (en) 1995-06-23 1997-01-22 Novartis Ag Flow cell
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface

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US6200814B1 (en) 2001-03-13
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US8021626B2 (en) 2011-09-20
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