DE69842040D1 - Verfahren mit Beziehung zu linearen Baken - Google Patents
Verfahren mit Beziehung zu linearen BakenInfo
- Publication number
- DE69842040D1 DE69842040D1 DE69842040T DE69842040T DE69842040D1 DE 69842040 D1 DE69842040 D1 DE 69842040D1 DE 69842040 T DE69842040 T DE 69842040T DE 69842040 T DE69842040 T DE 69842040T DE 69842040 D1 DE69842040 D1 DE 69842040D1
- Authority
- DE
- Germany
- Prior art keywords
- probe
- target sequence
- linear beacons
- donor
- method related
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6328397P | 1997-10-27 | 1997-10-27 | |
| US09/179,162 US6485901B1 (en) | 1997-10-27 | 1998-10-26 | Methods, kits and compositions pertaining to linear beacons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69842040D1 true DE69842040D1 (de) | 2011-01-20 |
Family
ID=26743242
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69828432T Expired - Lifetime DE69828432T2 (de) | 1997-10-27 | 1998-10-27 | Verfahren, kits und zusammenfassungen mit beziehung zu linearen baken |
| DE69842040T Expired - Lifetime DE69842040D1 (de) | 1997-10-27 | 1998-10-27 | Verfahren mit Beziehung zu linearen Baken |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69828432T Expired - Lifetime DE69828432T2 (de) | 1997-10-27 | 1998-10-27 | Verfahren, kits und zusammenfassungen mit beziehung zu linearen baken |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6485901B1 (de) |
| EP (2) | EP1484337B1 (de) |
| JP (2) | JP4372341B2 (de) |
| AT (2) | ATE490978T1 (de) |
| AU (1) | AU1121499A (de) |
| DE (2) | DE69828432T2 (de) |
| DK (1) | DK1027372T3 (de) |
| ES (1) | ES2235375T3 (de) |
| WO (1) | WO1999021881A1 (de) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6485901B1 (en) * | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US6361942B1 (en) | 1998-03-24 | 2002-03-26 | Boston Probes, Inc. | Method, kits and compositions pertaining to detection complexes |
| ATE449868T1 (de) | 1998-04-29 | 2009-12-15 | Boston Probes Inc | Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen |
| US6287772B1 (en) * | 1998-04-29 | 2001-09-11 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
| GB9815933D0 (en) | 1998-07-23 | 1998-09-23 | Secr Defence | Detection method |
| US6441152B1 (en) | 1998-12-08 | 2002-08-27 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
| US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
| US20040081959A9 (en) * | 1999-12-08 | 2004-04-29 | Epoch Biosciences, Inc. | Fluorescent quenching detection reagents and methods |
| US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| GB2359625B (en) | 1999-12-10 | 2004-10-20 | Molecular Light Tech Res Ltd | Monitoring oligonucleotide binding process using chemiluminescence quenching |
| US6579680B2 (en) | 2000-02-28 | 2003-06-17 | Corning Incorporated | Method for label-free detection of hybridized DNA targets |
| US6887664B2 (en) | 2000-06-06 | 2005-05-03 | Applera Corporation | Asynchronous primed PCR |
| CA2383939C (en) * | 2000-06-27 | 2009-12-01 | National Institute Of Advanced Industrial Science And Technology | Novel nucleic acid probes, method for determining nucleic acids by using the probes, and method for analyzing data obtained by the method |
| DE60138916D1 (de) | 2000-09-26 | 2009-07-16 | Boston Probes Inc | Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien |
| EP1356113B1 (de) | 2000-12-15 | 2012-07-18 | Life Technologies Corporation | Verfahren zum nachweis von organismen |
| CN100523216C (zh) * | 2001-03-02 | 2009-08-05 | 匹兹堡大学 | Pcr方法 |
| JP4408628B2 (ja) | 2001-03-09 | 2010-02-03 | ボストン プローブス，インコーポレイテッド | 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 |
| AU2007200335B2 (en) * | 2001-03-09 | 2009-01-22 | Boston Probes, Inc. | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation |
| US8026051B2 (en) | 2001-05-18 | 2011-09-27 | Boston Probes, Inc. | PNA probes, probe sets, methods and kits pertaining to the detection of Candida |
| US7297494B2 (en) * | 2001-06-25 | 2007-11-20 | Georgia Tech Research Corporation | Activatable probes and methods for in vivo gene detection |
| US20030129626A1 (en) | 2001-09-24 | 2003-07-10 | Nielsen Kirsten Vang | Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid |
| EP1444365A4 (de) * | 2001-10-25 | 2005-07-20 | Gorilla Genomics Inc | Asymmetrische pcr mit nukleasefreier polymerase oder nukleaseresistenten molecular beacons |
| JP2005520554A (ja) * | 2002-03-21 | 2005-07-14 | ボストン プローブス，インコーポレイテッド | ＢａｃｉｌｌｕｓＡｎｔｈｒａｃｉｓの検出に関するＰＮＡオリゴマー、オリゴマーセット、方法およびキット |
| US20030211509A1 (en) * | 2002-03-26 | 2003-11-13 | Wiley Steven R. | TNF-delta ligand and uses thereof |
| JP4457001B2 (ja) * | 2002-05-31 | 2010-04-28 | セクレタリー・デパートメント・オブ・アトミック・エナジー | ドナー／アクセプター部分が相補鎖上となる標的核酸検出のｍｅｔ／ｆｒｅｔに基づく方法 |
| EP2161276A3 (de) | 2002-09-08 | 2010-05-26 | Applera Corporation | PNA enthaltende Verbindungen, Bibliotheken und Methoden und PNA Oligomersynthese |
| US7803536B2 (en) * | 2002-09-20 | 2010-09-28 | Integrated Dna Technologies, Inc. | Methods of detecting fluorescence with anthraquinone quencher dyes |
| US20040259132A1 (en) * | 2002-11-22 | 2004-12-23 | Henrik Stender | Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto) |
| US8323897B2 (en) | 2002-12-04 | 2012-12-04 | Applied Biosystems, Llc | Multiplex amplification of polynucleotides |
| ATE488604T1 (de) * | 2003-05-20 | 2010-12-15 | Investigen Inc | System zum nachweis von polynukleotiden |
| WO2005020890A2 (en) * | 2003-07-11 | 2005-03-10 | Surromed, Inc. | Multiplexed molecular beacon assay for detection of pathogens |
| CN1860241A (zh) * | 2003-07-30 | 2006-11-08 | 财团法人理工学振兴会 | 部分双链型核酸分子 |
| US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
| WO2005029041A2 (en) * | 2003-09-19 | 2005-03-31 | Applera Corporation | High density sequence detection methods and apparatus |
| US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| WO2005049849A2 (en) | 2003-11-14 | 2005-06-02 | Integrated Dna Technologies, Inc. | Fluorescence quenching azo dyes, their methods of preparation and use |
| WO2005052193A2 (en) * | 2003-11-19 | 2005-06-09 | Applera Corporation | Methods for determining the degradation state or concentration of nucleic acids |
| EP1689764B1 (de) * | 2003-11-19 | 2013-01-02 | AlleLogic Biosciences Corporation | Mit mehreren fluorophoren markierte oligonukleotide |
| KR20150005720A (ko) * | 2004-02-18 | 2015-01-14 | 크로모셀 코포레이션 | 신호 프로브를 이용하는 방법 및 물질 |
| EP2208797A3 (de) | 2004-03-01 | 2010-11-24 | Applied Biosystems, LLC | Verfahren, Zusammensetzungen und Kits für Polynukleotidamplifikation |
| US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
| AU2005250432B2 (en) | 2004-05-28 | 2011-09-15 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US20060003337A1 (en) * | 2004-06-30 | 2006-01-05 | John Brandis | Detection of small RNAS |
| DE602005025782D1 (de) | 2004-09-21 | 2011-02-17 | Life Technologies Corp | Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas) |
| ES2534304T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| EP1885892A2 (de) * | 2005-05-03 | 2008-02-13 | Ensemble Discovery Corporation | Umsatzsonden und ihre verwendung zum nachweis von nukleinsäuren |
| CA2601554A1 (en) | 2005-05-20 | 2006-11-30 | Integrated Dna Technologies, Inc. | Compounds and methods for labeling oligonucleotides |
| AU2006252346B2 (en) * | 2005-06-02 | 2012-06-28 | Advandx, Inc. | Peptide nucleic acid probes for analysis of microorganisms |
| EP1994182B1 (de) | 2006-03-15 | 2019-05-29 | Siemens Healthcare Diagnostics Inc. | Abgleit-nucleobase-analoga |
| EP2004847B1 (de) | 2006-03-16 | 2017-05-03 | Pentabase Aps | Oligonukleotide mit signalpaaren und hydrophoben nukleotiden, stammlosen leuchttürmen zur detektion von nukleinsäuren, methylierungsstatus und mutanten von nukleinsäuren |
| US20080038783A1 (en) * | 2006-06-29 | 2008-02-14 | Applera Corporation | Compositions and Methods Pertaining to Guanylation of PNA Oligomers |
| EP2484781B1 (de) | 2006-08-01 | 2017-08-23 | Applied Biosystems, LLC | Nachweis von Analyten und Nukleinsäuren |
| AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
| US9938641B2 (en) * | 2006-12-18 | 2018-04-10 | Fluidigm Corporation | Selection of aptamers based on geometry |
| US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| EP2285960B1 (de) | 2008-05-08 | 2015-07-08 | Asuragen, INC. | Zusammensetzungen und verfahren in zusammenhang mit der mirna-184modulation von neovaskularisation oder angiogenese |
| EP2376659B1 (de) * | 2008-12-17 | 2015-12-02 | Life Technologies Corporation | Verfahren, zusammensetzungen und kits für den nachweis von allelen varianten |
| JP5805064B2 (ja) | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
| EP2634266B1 (de) | 2009-05-22 | 2015-10-14 | Asuragen, INC. | miRNA-Biomarker für Erkrankungen der Prostata |
| JP2012529908A (ja) | 2009-06-15 | 2012-11-29 | ネットバイオ・インコーポレーテッド | 法医学的ｄｎａの定量化のための改善された方法 |
| WO2011017567A1 (en) | 2009-08-05 | 2011-02-10 | Life Technologies Corporation | Methods for the analysis of proximity binding assay data |
| EP2775300A3 (de) | 2009-08-28 | 2015-04-01 | Asuragen, INC. | miRNA-Biomarker für Lungenerkrankungen |
| US9845492B2 (en) * | 2009-12-21 | 2017-12-19 | Seegene, Inc. | TSG primer target detection |
| US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
| US20120108799A1 (en) | 2010-09-07 | 2012-05-03 | Integrated Dna Technologies, Inc. | Modifications for Antisense Compounds |
| AU2011230496B2 (en) | 2010-03-26 | 2015-09-17 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
| US20110276317A1 (en) | 2010-04-11 | 2011-11-10 | Life Technologies Corporation | SYSTEMS AND METHODS FOR MODEL-BASED qPCR |
| US20110287425A1 (en) * | 2010-05-14 | 2011-11-24 | Kromatid, Inc. | Assays to Detect Small-Scale Mutations in Individual Cells |
| ES2908415T3 (es) | 2010-06-21 | 2022-04-29 | Life Technologies Corp | Composición y método para la síntesis y amplificación de ácidos nucleicos mediante el uso de RT |
| EP3502272A1 (de) | 2010-06-21 | 2019-06-26 | Life Technologies Corporation | Zusammensetzungen, kits und verfahren zur synthese und/oder zum nachweis von nukleinsäuren |
| JP5978220B2 (ja) | 2010-10-29 | 2016-08-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸ナノ構造バーコードプローブ |
| EP2641201B1 (de) | 2010-11-16 | 2018-12-26 | Life Technologies Corporation | Systeme und verfahren zur analyse von näherungsbindenden testdaten |
| EP2658998B1 (de) | 2010-12-29 | 2015-04-22 | Life Technologies Corporation | Ddao-verbindungen als fluorezenzreferenzstandards |
| ES2632768T3 (es) | 2011-01-17 | 2017-09-15 | Life Technologies Corporation | Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos |
| CN103459598B (zh) | 2011-02-03 | 2016-08-10 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| WO2012135620A2 (en) * | 2011-04-01 | 2012-10-04 | Advandx. Inc. | Molecular gram stain |
| US20140170653A1 (en) | 2011-04-15 | 2014-06-19 | Life Technologies Corporation | Chemical ligation |
| WO2012170907A2 (en) | 2011-06-08 | 2012-12-13 | Life Technologies Corporation | Polymerization of nucleic acids using proteins having low isoelectric points |
| CN103796987B (zh) | 2011-06-08 | 2016-09-21 | 生命技术公司 | 用于pcr系统的新型去污剂的设计和开发 |
| JP6154809B2 (ja) | 2011-06-27 | 2017-06-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アルツハイマー病を示すマイクロｒｎａバイオマーカー |
| EP2744912B1 (de) | 2011-08-18 | 2016-11-02 | Nestec S.A. | Zusammensetzungen und verfahren für den nachweis von allelvarianten |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| US20130179086A1 (en) | 2011-11-29 | 2013-07-11 | Life Technologies Corporation | Systems and methods for the determination of a copy number of a genomic sequence |
| WO2013131083A1 (en) | 2012-03-02 | 2013-09-06 | Winthrop-University Hospital | METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES |
| KR20210072137A (ko) | 2012-06-14 | 2021-06-16 | 라이프 테크놀로지스 코포레이션 | 폴리머라제 연쇄 반응 (pcr)을 위한 신규 조성물, 방법 및 키트 |
| WO2014059011A1 (en) | 2012-10-09 | 2014-04-17 | Advandx, Inc. | Devices, compositions and methods pertaining to microscopic analysis of microorganisms and other analytes of interest |
| EP3628746A1 (de) | 2012-11-02 | 2020-04-01 | Life Technologies Corporation | Erfassung, detektion und quantifizierung von kleiner rna |
| EP2929050A1 (de) | 2012-12-10 | 2015-10-14 | AdvanDx, Inc. | Verwendung von sonden zur massenspektrometrischen identifizierung von mikroorganismen oder zellen und relevanten erkrankungen von interesse |
| US11254977B2 (en) | 2013-03-12 | 2022-02-22 | Life Technologies Corporation | Universal reporter-based genotyping methods and materials |
| US20150080239A1 (en) | 2013-09-13 | 2015-03-19 | Life Technologies Corporation | Classification and Actionability Indices for Cancer |
| AU2014227883B9 (en) | 2013-03-15 | 2020-09-10 | Life Technologies Corporation | Classification and actionability indices for lung cancer |
| EP2981621B1 (de) | 2013-04-05 | 2019-05-22 | Life Technologies Corporation | Genfusionen |
| JP5928906B2 (ja) | 2013-08-27 | 2016-06-01 | 横河電機株式会社 | 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置 |
| JP6742238B2 (ja) | 2013-10-25 | 2020-08-19 | ライフ テクノロジーズ コーポレーション | Ｐｃｒシステムにおいて使用するための新規化合物及びその用途 |
| WO2015075198A1 (en) * | 2013-11-22 | 2015-05-28 | Orion Diagnostica Oy | Detection of nucleic acids by strand invasion based amplification |
| EP3090059B1 (de) | 2014-01-05 | 2018-06-06 | Biomirna Holdings Ltd. | Micro-rna quotienten zur bestimmung von lungenkrebs |
| US10619210B2 (en) | 2014-02-07 | 2020-04-14 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
| EP3438288A1 (de) | 2014-03-27 | 2019-02-06 | Life Technologies Corporation | Mit krebs assoziierte genfusionen und genvarianten |
| JP6523429B2 (ja) * | 2014-04-04 | 2019-05-29 | パナジン インコーポレイテッドＰａｎａｇｅｎｅ Ｉｎｃ． | Ｐｎａプローブを用いた融解曲線分析方法、融解曲線分析による塩基多型分析方法および塩基多型分析キット |
| CN107109474B (zh) | 2014-08-19 | 2021-03-19 | 豪夫迈·罗氏有限公司 | 用于核酸检测的方法和组合物 |
| WO2016094330A2 (en) | 2014-12-08 | 2016-06-16 | 20/20 Genesystems, Inc | Methods and machine learning systems for predicting the liklihood or risk of having cancer |
| WO2016092045A1 (en) | 2014-12-11 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting medically refractory acute severe colitis |
| US11639522B2 (en) | 2015-01-30 | 2023-05-02 | President And Fellows Of Harvard College | Microscope-free imaging |
| WO2016177774A1 (en) | 2015-05-04 | 2016-11-10 | Academisch Medisch Centrum | Method of quantifying mirnas using normalization |
| CN116949140A (zh) | 2016-02-17 | 2023-10-27 | 哈佛学院院长及董事 | 分子编程工具 |
| WO2017177025A1 (en) | 2016-04-06 | 2017-10-12 | Life Technologies Corporation | Compositions, methods, and kits for synthesis and detection of nucleic acids |
| US20170362640A1 (en) | 2016-06-16 | 2017-12-21 | Life Technologies Corporation | Novel compositions, methods and kits for microorganism detection |
| CN109689886A (zh) | 2016-08-26 | 2019-04-26 | 生命技术公司 | 核酸提取和扩增对照及其使用方法 |
| WO2018045162A1 (en) | 2016-09-01 | 2018-03-08 | Biogen Ma Inc. | Biomarkers predictive of primary progressive multiple sclerosis and uses thereof |
| CN110168101A (zh) | 2017-01-10 | 2019-08-23 | 哈佛学院院长及董事 | 多重信号放大 |
| CN111527216A (zh) | 2017-11-13 | 2020-08-11 | 生命技术公司 | 用于尿路微生物检测的组合物、方法和试剂盒 |
| US20200075129A1 (en) | 2018-08-30 | 2020-03-05 | Life Technologies Corporation | Machine learning system for genotyping pcr assays |
| US11836614B2 (en) | 2018-08-31 | 2023-12-05 | Life Technologies Corporation | Image driven quality control for array-based PCR |
| EP3719144A1 (de) | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung |
| US20220267857A1 (en) | 2019-07-19 | 2022-08-25 | Fundación Para La Investigación Biomédikca Del Hospital Universitario La Paz (Fibhulp) | Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc) |
| EP4185858A2 (de) | 2020-07-23 | 2023-05-31 | Life Technologies Corporation | Zusammensetzungen, systeme und verfahren zur biologischen analyse unter verwendung von farbstoffen |
| US20240060117A1 (en) | 2020-07-23 | 2024-02-22 | Life Technologies Corporation | Energy transfer dye conjugates for use in biological assays |
| EP4294833A2 (de) | 2021-02-22 | 2023-12-27 | Cotropia, Joseph | Coronavirus-antigene und epitope und proteine, die an diese binden |
| WO2022197882A1 (en) | 2021-03-18 | 2022-09-22 | Cotropia Joseph | Human immunodeficiency virus (hiv) antigens and epitopes and proteins that bind thereto |
| WO2023004400A1 (en) | 2021-07-21 | 2023-01-26 | Life Technologies Corporation | Dibenzoxanthene quenchers, uses, and methods of preparation |
| WO2023004356A2 (en) | 2021-07-21 | 2023-01-26 | Life Technologies Corporation | Azaindole cyanine dyes, uses, and methods of preparation |
| WO2023031770A1 (en) | 2021-08-30 | 2023-03-09 | Galderma Holding SA | Treatments for atopic dermatitis |
| WO2023039525A1 (en) | 2021-09-10 | 2023-03-16 | Life Technologies Corporation | Master mix compositions, kits, and methods |
| WO2023081221A1 (en) | 2021-11-02 | 2023-05-11 | Life Technologies Corporation | Compositions and methods for reducing master mix contamination |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4174384A (en) | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4261968A (en) | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US5601984A (en) | 1983-01-10 | 1997-02-11 | Gen-Probe Incorporated | Method for detecting, the presense or amount of a taxonomic group of organisms using specific R-RNA subsequences as probes |
| US5288611A (en) | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US4666862A (en) | 1984-08-14 | 1987-05-19 | Ortho Diagnostic Systems Inc. | Fluorescent energy transfer with phycobiliproteins |
| FR2572180B1 (fr) * | 1984-10-24 | 1987-03-20 | Eric Marteau D Autry | Procede et appareil de reparation d'echantillons a des fins d'analyse |
| US4822733A (en) | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
| US4725536A (en) | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
| US4725537A (en) | 1985-09-19 | 1988-02-16 | Allied Corporation | Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage |
| US4725538A (en) * | 1985-10-25 | 1988-02-16 | The Beth Israel Hospital Association | Method of assaying the presence of cancer cells |
| US4996143A (en) | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
| US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5635347A (en) | 1986-04-30 | 1997-06-03 | Igen, Inc. | Rapid assays for amplification products |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| EP0537270B1 (de) | 1990-07-02 | 1998-09-09 | The Regents Of The University Of California | Bestimmung von analyten durch übertragung von fluoreszenzenergie |
| US5439793A (en) | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5237515A (en) | 1991-04-10 | 1993-08-17 | University Of Utah Research Foundation | Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| CA2073630C (en) | 1991-08-30 | 2007-12-11 | Atsushi Ohshima | Method for synthesizing single-stranded stem-loop dnas, the products and uses therefor |
| US5787032A (en) | 1991-11-07 | 1998-07-28 | Nanogen | Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group |
| AU658962B2 (en) | 1991-11-15 | 1995-05-04 | Igen, Inc. | Rapid assays for amplification products |
| US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
| CA2087413A1 (en) | 1992-01-17 | 1993-07-18 | Joseph R. Lakowicz | Fluorescent energy transfer immunoassay |
| ATE244259T1 (de) | 1992-02-12 | 2003-07-15 | Chromagen Inc | Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen |
| DE69207580T2 (de) | 1992-03-23 | 1996-08-08 | Hoffmann La Roche | Verfahren zum DNS-Nachweis |
| US6020124A (en) | 1992-04-27 | 2000-02-01 | Trustees Of Dartmouth College | Detection of soluble gene sequences in biological fluids |
| GB9211979D0 (en) | 1992-06-05 | 1992-07-15 | Buchard Ole | Uses of nucleic acid analogues |
| WO1994002634A1 (en) | 1992-07-24 | 1994-02-03 | University Of South Australia | Amplification and detection process |
| JPH06153997A (ja) | 1992-11-27 | 1994-06-03 | Canon Inc | 検出信号増幅による標的核酸の検出方法 |
| EP0601889A2 (de) | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nukleinsäure-Sonden |
| GB9311386D0 (en) | 1993-06-02 | 1993-07-21 | Pna Diagnostics As | Nucleic acid analogue assay procedures |
| ATE218893T1 (de) * | 1993-08-12 | 2002-06-15 | Neurotech Sa | Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| CA2105364A1 (en) | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US6309823B1 (en) | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| EP0728218B1 (de) | 1993-11-12 | 2008-01-02 | PHRI Properties, Inc. | Hybridisierungsprobe zur nukleinsäuredetektion, universelle stammstrukturen, methoden und reagentiensätze |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| AU2522095A (en) | 1994-05-19 | 1995-12-18 | Dako A/S | Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US5629178A (en) | 1994-10-28 | 1997-05-13 | Genetics & Ivf Institute | Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA) |
| US5675517A (en) | 1995-04-25 | 1997-10-07 | Systemix | Fluorescence spectral overlap compensation for high speed flow cytometry systems |
| DE69610304T2 (de) | 1995-05-05 | 2001-04-05 | Perkin Elmer Corp | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| US5879885A (en) | 1995-06-07 | 1999-03-09 | Gen-Probe Incorporated | Compositions for detecting and quantifying biological samples |
| EP0845047A2 (de) | 1995-08-14 | 1998-06-03 | Abbott Laboratories | Eintopf-amplifikationstestverfahren für nukleinsäuren |
| US5770365A (en) | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
| DE69637086T2 (de) | 1995-10-12 | 2008-01-10 | Lansdorp, Peter M., Vancouver | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
| US5888733A (en) | 1995-11-16 | 1999-03-30 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
| JP4494529B2 (ja) | 1995-11-16 | 2010-06-30 | ダコ デンマーク アクティーゼルスカブ | 真核系サンプル中の特異的核酸配列を検出するためのｉｎ ｓｉｔｕハイブリダイゼーション |
| JP3439221B2 (ja) | 1995-12-18 | 2003-08-25 | ワシントン ユニヴァーシティ | 蛍光共鳴エネルギー移動を利用する核酸分析方法 |
| US5723294A (en) | 1996-03-05 | 1998-03-03 | Gull Laboratories | Methods for detection and discrimination of multiple analytes using fluorescent technology |
| DE69738687D1 (de) | 1996-04-12 | 2008-06-26 | Phri Properties Inc | Sonden, kits und assays |
| WO1998010096A1 (en) | 1996-04-12 | 1998-03-12 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| EP0912766B2 (de) | 1996-06-04 | 2011-12-14 | University of Utah Research Foundation | Überwachung der hybridisierung während pcr |
| US5780233A (en) | 1996-06-06 | 1998-07-14 | Wisconsin Alumni Research Foundation | Artificial mismatch hybridization |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5827660A (en) | 1996-08-09 | 1998-10-27 | University Of Massachusetts | Caged fluorochrome-labeled probes and subtraction of autoflourescence background |
| US5691145A (en) | 1996-08-27 | 1997-11-25 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets |
| US5853992A (en) | 1996-10-04 | 1998-12-29 | The Regents Of The University Of California | Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels |
| DE19782089T1 (de) | 1996-10-29 | 1999-12-23 | Univ Nebraska At Lincoln Linco | Verfahren zum Nachweisen von Punktmutationen in DNA unter Verwendung von Fluoreszenzenergieübergang |
| US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| US6451530B1 (en) | 1996-12-13 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent nucleotide analog hairpin formation for detection of nucleic acid hybridization |
| US5837466A (en) | 1996-12-16 | 1998-11-17 | Vysis, Inc. | Devices and methods for detecting nucleic acid analytes in samples |
| US6025133A (en) | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| US5804386A (en) | 1997-01-15 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Sets of labeled energy transfer fluorescent primers and their use in multi component analysis |
| DE69826992T2 (de) | 1997-02-24 | 2005-10-20 | Georgia Tech Research Corp. | Verfahren zur bestimmung einer nukleinsäure |
| US5846729A (en) | 1997-02-27 | 1998-12-08 | Lorne Park Research, Inc. | Assaying nucleotides in solution using a fluorescent intensity quenching effect |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| ATE478090T1 (de) | 1997-10-27 | 2010-09-15 | Boston Probes Inc | SICH AUF ßPNA MOLECULAR BEACONSß BEZIEHENDE VERFAHREN, TESTSÄTZE UND ZUSAMMENSETZUNGEN |
| US6361942B1 (en) | 1998-03-24 | 2002-03-26 | Boston Probes, Inc. | Method, kits and compositions pertaining to detection complexes |
-
1998
- 1998-10-26 US US09/179,162 patent/US6485901B1/en not_active Expired - Lifetime
- 1998-10-27 EP EP04019661A patent/EP1484337B1/de not_active Expired - Lifetime
- 1998-10-27 DE DE69828432T patent/DE69828432T2/de not_active Expired - Lifetime
- 1998-10-27 DK DK98953983T patent/DK1027372T3/da active
- 1998-10-27 AT AT04019661T patent/ATE490978T1/de not_active IP Right Cessation
- 1998-10-27 WO PCT/US1998/022630 patent/WO1999021881A1/en active IP Right Grant
- 1998-10-27 EP EP98953983A patent/EP1027372B1/de not_active Expired - Lifetime
- 1998-10-27 DE DE69842040T patent/DE69842040D1/de not_active Expired - Lifetime
- 1998-10-27 ES ES98953983T patent/ES2235375T3/es not_active Expired - Lifetime
- 1998-10-27 AT AT98953983T patent/ATE286066T1/de not_active IP Right Cessation
- 1998-10-27 AU AU11214/99A patent/AU1121499A/en not_active Abandoned
- 1998-10-27 JP JP2000517989A patent/JP4372341B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-10 US US09/950,459 patent/US6649349B2/en not_active Expired - Lifetime
-
2003
- 2003-06-30 US US10/610,337 patent/US7422852B2/en not_active Expired - Fee Related
-
2008
- 2008-09-08 US US12/206,393 patent/US7892741B2/en not_active Expired - Fee Related
- 2008-11-25 JP JP2008299911A patent/JP2009082137A/ja active Pending
-
2011
- 2011-01-13 US US13/006,345 patent/US20110250596A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE286066T1 (de) | 2005-01-15 |
| US7892741B2 (en) | 2011-02-22 |
| JP4372341B2 (ja) | 2009-11-25 |
| EP1027372B1 (de) | 2004-12-29 |
| DE69828432D1 (de) | 2005-02-03 |
| US6485901B1 (en) | 2002-11-26 |
| JP2003526597A (ja) | 2003-09-09 |
| ES2235375T3 (es) | 2005-07-01 |
| US6649349B2 (en) | 2003-11-18 |
| US20020064772A1 (en) | 2002-05-30 |
| EP1484337A2 (de) | 2004-12-08 |
| EP1484337B1 (de) | 2010-12-08 |
| ATE490978T1 (de) | 2010-12-15 |
| AU1121499A (en) | 1999-05-17 |
| EP1027372A1 (de) | 2000-08-16 |
| EP1484337A3 (de) | 2005-06-29 |
| US20070178471A1 (en) | 2007-08-02 |
| US7422852B2 (en) | 2008-09-09 |
| DE69828432T2 (de) | 2006-01-12 |
| US20090136941A1 (en) | 2009-05-28 |
| US20110250596A1 (en) | 2011-10-13 |
| JP2009082137A (ja) | 2009-04-23 |
| DK1027372T3 (da) | 2005-05-09 |
| WO1999021881A1 (en) | 1999-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69842040D1 (de) | Verfahren mit Beziehung zu linearen Baken | |
| WO1999022018A3 (en) | Methods, kits and compositions pertaining to pna molecular beacons | |
| NO900582L (no) | Maalemetode. | |
| DK0613502T3 (da) | Fremgangsmåde og reagenser til detektering af bakterier i cerebrospinalvæske | |
| ES2157229T3 (es) | Metodo, reactivos y kits para la deteccion de la neisseria gonorrhoeae y la chlamydia trachomatis. | |
| DE60232323D1 (de) | Verbessertes verfahren zum nachweis von atp | |
| ATE351921T1 (de) | Verfahren für fluoreszenzerkennungstest | |
| DK1921169T3 (da) | Hybridiseringssonder til nukleinsyredetektion, universelle stamceller, fremgangsmåder og kits | |
| DK0666927T3 (da) | Fremgangsmåde til påvisning af en nukleinsyresekvens. | |
| CY1107621T1 (el) | Μεθοδος ανιχνευσης αντισωματων σε ενα δειγμα | |
| CY1105025T1 (el) | Αναλυση λεπτινης βασιζομενη στην ανιχνευση εκφρασης ang-2 | |
| DE69105978D1 (de) | Verfahren zur verminderung von störungen in einer fluoreszenzbestimmung. | |
| DK0696642T3 (da) | Fremgangsmåde til påvisning af forstyrrelser i protein C/protein S-systemet | |
| EP0707075A3 (de) | Spezies-spezifischer Nachweis von Mycobacterium Kansasii | |
| DE50115528D1 (de) | Verfahren zur identifizierung einer auf einen körper aufgebrachten markierung | |
| DK1560929T3 (da) | Polynucleotider til amplifikation og detektion af chlamydia trachomatis og neisseria gonore | |
| DE59903466D1 (de) | Verfahren und vorrichtung zum identifizieren einer markierung | |
| ATE186600T1 (de) | Phosphattest | |
| ES2179948T3 (es) | Metodo para determinar la predisposicion genetica para espondiloartropatias seronegativas y productos utiles para el mismo. | |
| NO964803D0 (no) | Fremgangsmåte for måling av konsentrasjonen av glykoler/polyglykoler i fluiden, måleinstrument samt analysesett |