DE69840154D1 - Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters - Google Patents

Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters

Info

Publication number
DE69840154D1
DE69840154D1 DE69840154T DE69840154T DE69840154D1 DE 69840154 D1 DE69840154 D1 DE 69840154D1 DE 69840154 T DE69840154 T DE 69840154T DE 69840154 T DE69840154 T DE 69840154T DE 69840154 D1 DE69840154 D1 DE 69840154D1
Authority
DE
Germany
Prior art keywords
disease
gene transcription
disease based
diagnosing alzheimer
transcription pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840154T
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English (en)
Inventor
Praveen Sharma
Anders Loenneborg
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Diagenic AS
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Diagenic AS
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Publication of DE69840154D1 publication Critical patent/DE69840154D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
DE69840154T 1997-04-30 1998-04-30 Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters Expired - Lifetime DE69840154D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO972006A NO972006D0 (no) 1997-04-30 1997-04-30 Ny metode for diagnose av sykdommer

Publications (1)

Publication Number Publication Date
DE69840154D1 true DE69840154D1 (de) 2008-12-04

Family

ID=19900683

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69828392T Expired - Lifetime DE69828392T2 (de) 1997-04-30 1998-04-30 Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters
DE69840154T Expired - Lifetime DE69840154D1 (de) 1997-04-30 1998-04-30 Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69828392T Expired - Lifetime DE69828392T2 (de) 1997-04-30 1998-04-30 Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters

Country Status (13)

Country Link
US (4) US6720138B2 (de)
EP (3) EP2050825A1 (de)
JP (1) JP4163758B2 (de)
AT (2) ATE286143T1 (de)
AU (1) AU7222698A (de)
CY (1) CY1108716T1 (de)
DE (2) DE69828392T2 (de)
DK (2) DK1323728T3 (de)
ES (2) ES2230688T3 (de)
HK (2) HK1026003A1 (de)
NO (2) NO972006D0 (de)
PT (2) PT1323728E (de)
WO (1) WO1998049342A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US20040248169A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of obesity related gene transcripts in blood
US20040248170A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of hyperlipidemia related gene transcripts in blood
WO2000040749A2 (en) 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
US20050003394A1 (en) * 1999-01-06 2005-01-06 Chondrogene Limited Method for the detection of rheumatoid arthritis related gene transcripts in blood
US20060134635A1 (en) * 2001-02-28 2006-06-22 Chondrogene Limited Method for the detection of coronary artery disease related gene transcripts in blood
US20040265868A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of depression related gene transcripts in blood
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
US20040241728A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US20070031841A1 (en) * 2001-02-28 2007-02-08 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US20040241726A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US6365376B1 (en) * 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
US7005256B1 (en) 1999-03-10 2006-02-28 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
AU782926B2 (en) * 1999-03-10 2005-09-08 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
EP1208228A2 (de) * 1999-05-19 2002-05-29 Mitokor Differentielle genexpression in spezifischen regionen vom gehirn in neurodegenerativen erkrankungen
DK1410011T3 (da) * 2001-06-18 2011-07-18 Netherlands Cancer Inst Diagnose og prognose for brystcancerpatienter
US20050064446A1 (en) * 2001-11-01 2005-03-24 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
GB0227238D0 (en) * 2002-11-21 2002-12-31 Diagenic As Product and method
US7790867B2 (en) 2002-12-05 2010-09-07 Rosetta Genomics Inc. Vaccinia virus-related nucleic acids and microRNA
FR2853907B1 (fr) * 2003-04-18 2007-08-03 Commissariat Energie Atomique Procede de preparation de fragments d'adn par fragmentation selective d'acides nucleiques et ses applications
US7888497B2 (en) * 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
WO2005076939A2 (en) * 2004-02-09 2005-08-25 University Of Kentucky Research Foundation Assay and method for diagnosing and treating alzheimer’s disease
US7593483B2 (en) * 2004-05-07 2009-09-22 Broadcom Corporation Nonlinear mapping in digital-to-analog and analog-to-digital converters
US7687616B1 (en) 2004-05-14 2010-03-30 Rosetta Genomics Ltd Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
AU2005243410B2 (en) 2004-05-14 2010-04-22 Rosetta Genomics Ltd. Micronas and uses thereof
US7795419B2 (en) 2004-05-26 2010-09-14 Rosetta Genomics Ltd. Viral and viral associated miRNAs and uses thereof
CA2572450A1 (en) 2004-05-28 2005-12-15 Ambion, Inc. Methods and compositions involving microrna
GB0412301D0 (en) * 2004-06-02 2004-07-07 Diagenic As Product and method
US7867703B2 (en) * 2004-08-26 2011-01-11 Agilent Technologies, Inc. Element defined sequence complexity reduction
US7713693B1 (en) 2004-09-01 2010-05-11 University Of Louisiana At Monroe Human cancer cell specific gene transcript
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
EP2520669A3 (de) * 2005-02-07 2013-02-27 GeneNews Inc. Biomarker für milde Arthrose und Verwendungen davon
US20070082350A1 (en) * 2005-02-09 2007-04-12 Philip Landfield Assay and method for diagnosing and treating alzheimer's disease
GB2449819A (en) * 2006-02-28 2008-12-03 Univ California Genes differentially expressed in bipolar disorder and/or schizophrenia
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
EP2145001A2 (de) * 2006-09-19 2010-01-20 Asuragen, Inc. Von mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulierte gene und stoffwechselwege als ziele für einen therapeutischen eingriff
US20090029868A1 (en) * 2006-10-31 2009-01-29 Applera Corporation Expression signature in peripheral blood for detection of aortic aneurysm
CA2671194A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
EP2104737B1 (de) * 2006-12-08 2013-04-10 Asuragen, INC. Funktionen und ziele von let-7-mikro-rnas
CA2671294A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
EP2167138A2 (de) * 2007-06-08 2010-03-31 Asuragen, INC. Mir-34-regulierte gene und pfade als targets für therapeutische intervention
US8361714B2 (en) * 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20090186015A1 (en) * 2007-10-18 2009-07-23 Latham Gary J Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
EP2990487A1 (de) 2008-05-08 2016-03-02 Asuragen, INC. Zusammensetzungen und verfahren in zusammenhang mit der mirna-modulation von neovaskularisation oder angiogenese
KR20110057188A (ko) * 2008-08-27 2011-05-31 하. 룬트벡 아크티에 셀스카브 바이오마커 프로파일 측정 시스템 및 방법
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
GB201000688D0 (en) 2010-01-15 2010-03-03 Diagenic Asa Product and method
EP3214174B1 (de) 2010-03-04 2019-10-16 InteRNA Technologies B.V. Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten
NZ704322A (en) 2010-07-06 2016-07-29 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CA2817882C (en) 2010-11-17 2022-08-23 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
US9222085B2 (en) 2011-02-03 2015-12-29 Mirna Therapeutics, Inc. Synthetic mimics of MIR-124
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
US9746458B2 (en) * 2011-04-27 2017-08-29 Loma Linda University Medical Center Dynactin subunit p62 biomarker for neurological conditions
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
WO2013063544A1 (en) 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
WO2013064702A2 (en) 2011-11-03 2013-05-10 Diagenic Asa Probes for diagnosis and monitoring of neurodegenerative disease
WO2014007623A1 (en) 2012-07-03 2014-01-09 Interna Technologies B.V. Diagnostic portfolio and its uses
WO2014055117A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
WO2014151551A1 (en) 2013-03-15 2014-09-25 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
EP2970909A4 (de) 2013-03-15 2017-02-15 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität
CA3079524A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
JP2802125B2 (ja) 1989-06-23 1998-09-24 キヤノン株式会社 核酸の検出方法
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
EP0534640B1 (de) * 1991-09-23 1996-10-02 Pfizer Inc. Verfahren für die Detektion von spezifische mRNS und DNS in Zellen
GB2260811B (en) 1991-10-23 1995-07-05 Yorkshire Cancer Research Camp Detection of malignant tumours
JPH07507446A (ja) 1992-03-04 1995-08-24 シナプティック・ファーマスーティカル・コーポレーション タウリン及びgabaの輸送体をコードするdna並びにその使用
US6114114A (en) 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
EP0667920B1 (de) * 1992-10-29 2003-01-15 Thomas Jefferson University Methoden zur detektion von mikrometastasen bei prostata-krebs
US5633137A (en) 1992-12-01 1997-05-27 The University Of South Florida Method for measuring specific gene expression: transcriptional activity per gene dose
US5677125A (en) 1994-01-14 1997-10-14 Vanderbilt University Method of detection and diagnosis of pre-invasive cancer
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6156502A (en) 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
US6228575B1 (en) 1996-02-08 2001-05-08 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
AU4327697A (en) 1996-08-20 1998-03-06 Motorola, Inc. Method and apparatus for detecting predetermined molecular structures in a sample
AU722819B2 (en) * 1996-12-06 2000-08-10 Urocor, Inc. Diagnosis of disease state using mRNA profiles
US6235474B1 (en) 1996-12-30 2001-05-22 The Johns Hopkins University Methods and kits for diagnosing and determination of the predisposition for diseases
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
WO1999006831A2 (en) 1997-07-29 1999-02-11 Dorssers Lambert C J Breast cancer resistance genes, methods for their detection and uses thereof
US6607879B1 (en) * 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
DE69934222T2 (de) 1998-02-25 2007-10-25 The United States Government As Represented By The Department Human Services Zellulare anordnungen für schnelle molekulare profilidentifizierung
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
CN1313908A (zh) 1998-08-21 2001-09-19 纳克斯科尔公司 使用可交联的固定的核酸的检测法
US6593084B2 (en) 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
AU1115200A (en) 1998-10-13 2000-05-01 Clontech Laboratories, Inc. Nucleic acid arrays
EP1131470A4 (de) 1998-10-28 2004-11-10 Vysis Inc Zelluläre arrays sowie verfahren zur detektion und verwendung von markern für genetische störungen
WO2000026412A1 (en) 1998-11-02 2000-05-11 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
US20040241727A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of schizophrenia related gene transcripts in blood
US20040248170A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of hyperlipidemia related gene transcripts in blood
US20040241728A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US20040241726A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US20050003394A1 (en) * 1999-01-06 2005-01-06 Chondrogene Limited Method for the detection of rheumatoid arthritis related gene transcripts in blood
WO2000040749A2 (en) * 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
US20040265869A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of type II diabetes related gene transcripts in blood
US7473528B2 (en) * 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US20040248169A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of obesity related gene transcripts in blood
US20040265868A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of depression related gene transcripts in blood
US20050042630A1 (en) * 1999-01-06 2005-02-24 Chondrogene Limited Method for the detection of asthma related gene transcripts in blood
US20020169560A1 (en) * 2001-05-12 2002-11-14 X-Mine Analysis mechanism for genetic data

Also Published As

Publication number Publication date
ES2230688T3 (es) 2005-05-01
ES2316693T3 (es) 2009-04-16
ATE412003T1 (de) 2008-11-15
US20020022222A1 (en) 2002-02-21
ATE286143T1 (de) 2005-01-15
JP4163758B2 (ja) 2008-10-08
JP2001526534A (ja) 2001-12-18
EP1323728A3 (de) 2004-02-04
US20130337446A1 (en) 2013-12-19
EP0979308A1 (de) 2000-02-16
DE69828392D1 (de) 2005-02-03
NO327084B1 (no) 2009-04-20
WO1998049342A1 (en) 1998-11-05
PT1323728E (pt) 2009-01-23
EP0979308B1 (de) 2004-12-29
NO20040371L (no) 1999-12-14
PT979308E (pt) 2005-03-31
US20040121390A1 (en) 2004-06-24
DK1323728T3 (da) 2009-03-02
CY1108716T1 (el) 2014-04-09
AU7222698A (en) 1998-11-24
US6720138B2 (en) 2004-04-13
US20050227286A1 (en) 2005-10-13
EP2050825A1 (de) 2009-04-22
NO972006D0 (no) 1997-04-30
EP1323728B1 (de) 2008-10-22
DE69828392T2 (de) 2005-12-01
EP1323728A2 (de) 2003-07-02
HK1026003A1 (en) 2000-12-01
DK0979308T3 (da) 2005-04-18
HK1057217A1 (en) 2004-03-19

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