DE69828392D1 - Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters - Google Patents

Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters

Info

Publication number
DE69828392D1
DE69828392D1 DE69828392T DE69828392T DE69828392D1 DE 69828392 D1 DE69828392 D1 DE 69828392D1 DE 69828392 T DE69828392 T DE 69828392T DE 69828392 T DE69828392 T DE 69828392T DE 69828392 D1 DE69828392 D1 DE 69828392D1
Authority
DE
Germany
Prior art keywords
preparation
standard diagnostic
diagnostic gene
gene transcription
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828392T
Other languages
English (en)
Other versions
DE69828392T2 (de
Inventor
Praveen Sharma
Anders Loenneborg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diagenic AS
Original Assignee
Diagenic AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagenic AS filed Critical Diagenic AS
Application granted granted Critical
Publication of DE69828392D1 publication Critical patent/DE69828392D1/de
Publication of DE69828392T2 publication Critical patent/DE69828392T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
DE69828392T 1997-04-30 1998-04-30 Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters Expired - Lifetime DE69828392T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO972006A NO972006D0 (no) 1997-04-30 1997-04-30 Ny metode for diagnose av sykdommer
NO972006 1997-04-30
PCT/GB1998/001261 WO1998049342A1 (en) 1997-04-30 1998-04-30 Method of preparing a standard diagnostic gene transcript pattern

Publications (2)

Publication Number Publication Date
DE69828392D1 true DE69828392D1 (de) 2005-02-03
DE69828392T2 DE69828392T2 (de) 2005-12-01

Family

ID=19900683

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69840154T Expired - Lifetime DE69840154D1 (de) 1997-04-30 1998-04-30 Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters
DE69828392T Expired - Lifetime DE69828392T2 (de) 1997-04-30 1998-04-30 Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69840154T Expired - Lifetime DE69840154D1 (de) 1997-04-30 1998-04-30 Verfahren zur Diagnose der Alzheimer Erkrankung auf der Basis eines Gen Transkriptionsmusters

Country Status (13)

Country Link
US (4) US6720138B2 (de)
EP (3) EP1323728B1 (de)
JP (1) JP4163758B2 (de)
AT (2) ATE412003T1 (de)
AU (1) AU7222698A (de)
CY (1) CY1108716T1 (de)
DE (2) DE69840154D1 (de)
DK (2) DK1323728T3 (de)
ES (2) ES2230688T3 (de)
HK (2) HK1026003A1 (de)
NO (2) NO972006D0 (de)
PT (2) PT979308E (de)
WO (1) WO1998049342A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US20060134635A1 (en) * 2001-02-28 2006-06-22 Chondrogene Limited Method for the detection of coronary artery disease related gene transcripts in blood
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
WO2000040749A2 (en) * 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
US20040248169A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of obesity related gene transcripts in blood
US20040265868A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of depression related gene transcripts in blood
US20050003394A1 (en) * 1999-01-06 2005-01-06 Chondrogene Limited Method for the detection of rheumatoid arthritis related gene transcripts in blood
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US20070031841A1 (en) * 2001-02-28 2007-02-08 Choong-Chin Liew Method for the detection of gene transcripts in blood and uses thereof
US20040241726A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US20040248170A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of hyperlipidemia related gene transcripts in blood
US20040241728A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US6365376B1 (en) * 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
DE60024629T2 (de) * 1999-03-10 2006-09-07 Cold Spring Harbor Laboratory Genchiptechnologie zur bestimmung von gedächtnisgenen
US7005256B1 (en) 1999-03-10 2006-02-28 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
AU5150300A (en) * 1999-05-19 2000-12-05 Mitokor Differential gene expression in specific regions of the brain in neurodegenerative diseases
US7514209B2 (en) 2001-06-18 2009-04-07 Rosetta Inpharmatics Llc Diagnosis and prognosis of breast cancer patients
US20050064446A1 (en) * 2001-11-01 2005-03-24 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
GB0227238D0 (en) * 2002-11-21 2002-12-31 Diagenic As Product and method
US7217807B2 (en) * 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
FR2853907B1 (fr) * 2003-04-18 2007-08-03 Commissariat Energie Atomique Procede de preparation de fragments d'adn par fragmentation selective d'acides nucleiques et ses applications
US7888497B2 (en) * 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
WO2005076939A2 (en) * 2004-02-09 2005-08-25 University Of Kentucky Research Foundation Assay and method for diagnosing and treating alzheimer’s disease
US7593483B2 (en) * 2004-05-07 2009-09-22 Broadcom Corporation Nonlinear mapping in digital-to-analog and analog-to-digital converters
EP1784501B1 (de) 2004-05-14 2015-11-18 Rosetta Genomics Ltd Micro-rnas und deren verwendung
US7687616B1 (en) 2004-05-14 2010-03-30 Rosetta Genomics Ltd Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
US7795419B2 (en) 2004-05-26 2010-09-14 Rosetta Genomics Ltd. Viral and viral associated miRNAs and uses thereof
EP2290071B1 (de) 2004-05-28 2014-12-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
GB0412301D0 (en) * 2004-06-02 2004-07-07 Diagenic As Product and method
US7867703B2 (en) * 2004-08-26 2011-01-11 Agilent Technologies, Inc. Element defined sequence complexity reduction
US7713693B1 (en) 2004-09-01 2010-05-11 University Of Louisiana At Monroe Human cancer cell specific gene transcript
DK2302055T3 (da) 2004-11-12 2014-10-13 Asuragen Inc Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
EP2520669A3 (de) * 2005-02-07 2013-02-27 GeneNews Inc. Biomarker für milde Arthrose und Verwendungen davon
US20070082350A1 (en) * 2005-02-09 2007-04-12 Philip Landfield Assay and method for diagnosing and treating alzheimer's disease
WO2007100913A2 (en) * 2006-02-28 2007-09-07 The Regents Of The University Of California Genes differentially expressed in bipolar disorder and/or schizophrenia
EP2115138A2 (de) 2006-09-19 2009-11-11 Asuragen, Inc. Bei pankreatischen erkrankungen differentiell exprimierte mikro-rnas und verwendungen davon
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US20090029868A1 (en) * 2006-10-31 2009-01-29 Applera Corporation Expression signature in peripheral blood for detection of aortic aneurysm
EP2104734A2 (de) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-20-regulierte gene und pfade als ziele für therapeutische interventionen
CA2671294A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
AU2008261951A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US20110172501A1 (en) * 2008-08-27 2011-07-14 Irina Antonijevic System and methods for measuring biomarker profiles
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
GB201000688D0 (en) 2010-01-15 2010-03-03 Diagenic Asa Product and method
ES2631458T3 (es) 2010-03-04 2017-08-31 Interna Technologies B.V. Molécula de ARNmi definida por su fuente y sus usos terapéuticos en el cáncer asociado a la EMT
CA2804599C (en) 2010-07-06 2023-01-31 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
WO2012068400A2 (en) 2010-11-17 2012-05-24 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
EP2670849A1 (de) 2011-02-03 2013-12-11 Mirna Therapeutics, Inc. Synthetische mimetika von mir-124
CA2828532A1 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
US9746458B2 (en) * 2011-04-27 2017-08-29 Loma Linda University Medical Center Dynactin subunit p62 biomarker for neurological conditions
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
WO2013063544A1 (en) 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
WO2013064702A2 (en) 2011-11-03 2013-05-10 Diagenic Asa Probes for diagnosis and monitoring of neurodegenerative disease
WO2014007623A1 (en) 2012-07-03 2014-01-09 Interna Technologies B.V. Diagnostic portfolio and its uses
WO2014055117A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
ES2935257T3 (es) 2013-03-15 2023-03-03 Univ Chicago Métodos y composiciones relacionadas con la actividad de las células T
WO2014145612A1 (en) 2013-03-15 2014-09-18 Ajay Goel Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
CA2905949A1 (en) 2013-03-15 2014-09-25 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
US11497762B2 (en) 2017-11-03 2022-11-15 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
JP2802125B2 (ja) 1989-06-23 1998-09-24 キヤノン株式会社 核酸の検出方法
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
EP0534640B1 (de) * 1991-09-23 1996-10-02 Pfizer Inc. Verfahren für die Detektion von spezifische mRNS und DNS in Zellen
GB2260811B (en) 1991-10-23 1995-07-05 Yorkshire Cancer Research Camp Detection of malignant tumours
WO1993018143A1 (en) 1992-03-04 1993-09-16 Synaptic Pharmaceutical Corporation Dna encoding taurine and gaba transporters and uses thereof
US6114114A (en) 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
CA2148350A1 (en) * 1992-10-29 1994-05-11 Carlo Croce Methods of detecting micrometastasis of prostate cancer
US5633137A (en) 1992-12-01 1997-05-27 The University Of South Florida Method for measuring specific gene expression: transcriptional activity per gene dose
US5677125A (en) 1994-01-14 1997-10-14 Vanderbilt University Method of detection and diagnosis of pre-invasive cancer
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6156502A (en) 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
AU2253397A (en) 1996-01-23 1997-08-20 Affymetrix, Inc. Nucleic acid analysis techniques
EP0937159A4 (de) 1996-02-08 2004-10-20 Affymetrix Inc Speziesbestimmung und phenotypische charakterisierung von mikroorganismen auf der basis eines chips
WO1998008083A1 (en) 1996-08-20 1998-02-26 Motorola Inc. Method and apparatus for detecting predetermined molecular structures in a sample
EP0960214A4 (de) * 1996-12-06 2004-08-04 Urocor Inc Diagnose des Krankheitszustandesan HAnd von mRNA-Profilen
US6235474B1 (en) 1996-12-30 2001-05-22 The Johns Hopkins University Methods and kits for diagnosing and determination of the predisposition for diseases
US6190857B1 (en) 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
AU9071098A (en) 1997-07-29 1999-02-22 Lambert C. J. Dorssers Breast cancer resistance genes, methods for their detection and uses thereof
US6607879B1 (en) * 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
CA2318789C (en) 1998-02-25 2011-05-10 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
AU5779399A (en) 1998-08-21 2000-03-27 Naxcor Assays using crosslinkable immobilized nucleic acids
US6593084B2 (en) 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
AU1115200A (en) 1998-10-13 2000-05-01 Clontech Laboratories, Inc. Nucleic acid arrays
WO2000024940A1 (en) 1998-10-28 2000-05-04 Vysis, Inc. Cellular arrays and methods of detecting and using genetic disorder markers
WO2000026412A1 (en) 1998-11-02 2000-05-11 Kenneth Loren Beattie Nucleic acid analysis using sequence-targeted tandem hybridization
US20040248169A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of obesity related gene transcripts in blood
US20050042630A1 (en) * 1999-01-06 2005-02-24 Chondrogene Limited Method for the detection of asthma related gene transcripts in blood
US7473528B2 (en) * 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US20040265868A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of depression related gene transcripts in blood
US20040265869A1 (en) * 1999-01-06 2004-12-30 Chondrogene Limited Method for the detection of type II diabetes related gene transcripts in blood
US20040241726A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US20040241728A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US20040241727A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of schizophrenia related gene transcripts in blood
US20050003394A1 (en) * 1999-01-06 2005-01-06 Chondrogene Limited Method for the detection of rheumatoid arthritis related gene transcripts in blood
WO2000040749A2 (en) * 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
US20040248170A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of hyperlipidemia related gene transcripts in blood
US20020169560A1 (en) * 2001-05-12 2002-11-14 X-Mine Analysis mechanism for genetic data

Also Published As

Publication number Publication date
DE69828392T2 (de) 2005-12-01
EP1323728B1 (de) 2008-10-22
JP4163758B2 (ja) 2008-10-08
NO327084B1 (no) 2009-04-20
US20040121390A1 (en) 2004-06-24
EP1323728A2 (de) 2003-07-02
JP2001526534A (ja) 2001-12-18
HK1026003A1 (en) 2000-12-01
US20020022222A1 (en) 2002-02-21
EP0979308B1 (de) 2004-12-29
ES2230688T3 (es) 2005-05-01
EP1323728A3 (de) 2004-02-04
ATE286143T1 (de) 2005-01-15
HK1057217A1 (en) 2004-03-19
US6720138B2 (en) 2004-04-13
AU7222698A (en) 1998-11-24
US20130337446A1 (en) 2013-12-19
DK0979308T3 (da) 2005-04-18
EP0979308A1 (de) 2000-02-16
ATE412003T1 (de) 2008-11-15
DE69840154D1 (de) 2008-12-04
ES2316693T3 (es) 2009-04-16
PT979308E (pt) 2005-03-31
NO20040371L (no) 1999-12-14
US20050227286A1 (en) 2005-10-13
EP2050825A1 (de) 2009-04-22
PT1323728E (pt) 2009-01-23
NO972006D0 (no) 1997-04-30
WO1998049342A1 (en) 1998-11-05
DK1323728T3 (da) 2009-03-02
CY1108716T1 (el) 2014-04-09

Similar Documents

Publication Publication Date Title
DE69828392D1 (de) Verfahren zur Herstellung eines diagnostischen Standard-Gentranskriptionsmusters
WO2000077260A8 (en) Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
US5650277A (en) Method of determining the presence and quantifying the number of di- and trinucleotide repeats
NZ786185A (en) Determination of base modifications of nucleic acids
ATE361996T1 (de) Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
ATE333517T1 (de) Verfahren und sondenset zur erkennung von krebs
CA2437737A1 (en) Methods and compositions of amplifying rna
DE60126090D1 (de) Diagnostische methode zur identifizierung von fötaler dna in einer maternalen probe
WO2008039071A3 (en) High-throughput diagnostic testing using arrays
CN109852667A (zh) 基于单分子力谱探测核酸末端结构的方法
CN112779320A (zh) 多区域dna甲基化检测探针设计及其检测方法
ATE220427T1 (de) Verfahren zum nachweis von nukleinsäure- zielsequenzen mittels in vitro transkription von einem rna-promoter
CN107893067A (zh) 用于高通量测序的基于固相载体膜富集目标核酸的方法
JPWO2005118791A1 (ja) 微量試料を用いる網羅的遺伝子発現プロフィール解析法
DE50206574D1 (de) Verfahren zur herstellung eines arrays zur detektion von komponenten aus einer biologischen probe
DE60121547T2 (de) Elektrochemisches Verfahren zum Nachweis von Nukleinsäuren
EP4265721A1 (de) Verfahren zur beurteilung der adapterligationseffizienz in einer sequenz einer dna-probe
CN108728555A (zh) 一种外周血与月经血鉴别用试剂盒及其应用
WO2007133189A3 (en) Methods and agents for detecting parechovirus
DE69535023D1 (de) Ein diagnose-verfahren und ein testsatz für die bestimmung des kell blutgruppln-nenotyps
EP0991780A2 (de) Verfahren und testkit zum nachweis bösartiger tumore
CN114438219A (zh) 长链非编码rna作为人源胚胎干细胞标志物的应用
DE19937234A1 (de) Borna Disease Virus (BDV)- spezifische Nukleinsäuresequenzen - ihre Anwendung in Diagnostik und Therapie
US20020012941A1 (en) Method for screening for unknown organisms
WO1999024607A3 (en) DETECTION AND TYPING OF THE iceA GENE OF $i(HELICOBACTER PYLORI)

Legal Events

Date Code Title Description
8364 No opposition during term of opposition