DE69824842D1 - Kontrastmittel, die auf angiogenese-rezeptoren zielen - Google Patents
Kontrastmittel, die auf angiogenese-rezeptoren zielenInfo
- Publication number
- DE69824842D1 DE69824842D1 DE69824842T DE69824842T DE69824842D1 DE 69824842 D1 DE69824842 D1 DE 69824842D1 DE 69824842 T DE69824842 T DE 69824842T DE 69824842 T DE69824842 T DE 69824842T DE 69824842 D1 DE69824842 D1 DE 69824842D1
- Authority
- DE
- Germany
- Prior art keywords
- contrast agent
- contrast agents
- moiety
- agents targeting
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9708265.5A GB9708265D0 (en) | 1997-04-24 | 1997-04-24 | Contrast agents |
GB9708265 | 1997-04-24 | ||
PCT/GB1998/001197 WO1998047541A1 (en) | 1997-04-24 | 1998-04-24 | Contrast agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69824842D1 true DE69824842D1 (de) | 2004-08-05 |
DE69824842T2 DE69824842T2 (de) | 2005-11-17 |
Family
ID=10811256
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69824842T Expired - Lifetime DE69824842T2 (de) | 1997-04-24 | 1998-04-24 | Kontrastmittel, die auf angiogenese-rezeptoren zielen |
DE69837975T Expired - Lifetime DE69837975T2 (de) | 1997-04-24 | 1998-04-24 | Diagnostisches Abbildungsverfahren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69837975T Expired - Lifetime DE69837975T2 (de) | 1997-04-24 | 1998-04-24 | Diagnostisches Abbildungsverfahren |
Country Status (10)
Country | Link |
---|---|
US (2) | US6610269B1 (de) |
EP (2) | EP1442751B1 (de) |
JP (1) | JP4993419B2 (de) |
AT (2) | ATE270116T1 (de) |
AU (1) | AU7068798A (de) |
DE (2) | DE69824842T2 (de) |
DK (1) | DK1442751T3 (de) |
ES (2) | ES2224379T3 (de) |
GB (1) | GB9708265D0 (de) |
WO (1) | WO1998047541A1 (de) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
CA2324555A1 (en) | 1998-03-31 | 1999-11-18 | Du Pont Pharmaceuticals Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
US6652836B2 (en) | 1998-10-15 | 2003-11-25 | Fluoroprobe, Inc. | Method for viewing tumor tissue located within a body cavity |
US6284223B1 (en) * | 1998-10-15 | 2001-09-04 | Fluoroprobe, Inc. | Method for viewing tumor tissue located within a body cavity |
US6299860B1 (en) | 1998-10-15 | 2001-10-09 | Fluoro Probe, Inc. | Method for viewing diseased tissue located within a body cavity |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
JP2002532440A (ja) | 1998-12-18 | 2002-10-02 | デュポン ファーマシューティカルズ カンパニー | ビトロネクチン受容体拮抗剤薬剤 |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6558649B1 (en) | 1998-12-18 | 2003-05-06 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
DE19924138A1 (de) | 1999-05-26 | 2000-11-30 | Henkel Kgaa | Lösbare Klebeverbindungen |
GB9922173D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
EP1239887A1 (de) * | 1999-10-15 | 2002-09-18 | Mayo Foundation For Medical Education And Research | Cobalamin-konjugate geeignet zur verwendung wie bilderzeugungs- oder therapeutische mitteln |
DE19951599A1 (de) * | 1999-10-27 | 2001-05-23 | Henkel Kgaa | Verfahren zur adhesiven Trennung von Klebeverbunden |
EP1267935A2 (de) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Behandlung von augenerkrankungen |
US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
US6989139B2 (en) | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
DK1272507T3 (da) | 2000-04-12 | 2005-10-03 | Amersham Health As | Integrinbindende peptidderivater |
CA2410906C (en) | 2000-06-02 | 2012-10-02 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (ec)-drug conjugates |
US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
EP1289565B1 (de) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Arzneimitteln zur zielgerichtung von endothelzellen |
AU7002501A (en) * | 2000-06-21 | 2002-01-02 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals for use in combination therapy |
DE10037884A1 (de) * | 2000-08-03 | 2002-02-21 | Henkel Kgaa | Verfahren zur beschleunigten Klebstoffaushärtung |
NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
PL207834B1 (pl) | 2001-07-10 | 2011-02-28 | Ge Healthcare As | Związki na bazie peptydów, ich zastosowanie oraz zawierająca je kompozycja farmaceutyczna |
US7087212B2 (en) * | 2001-08-17 | 2006-08-08 | Mallinckrodt, Inc | Multicomponent assemblies having enhanced binding properties for diagnosis and therapy |
US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) * | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7666979B2 (en) | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
EP1369134A1 (de) * | 2002-06-05 | 2003-12-10 | Bracco Imaging S.p.A. | Mittel fur magnetisches Bildformungsverfahren |
JP2004138397A (ja) * | 2002-10-15 | 2004-05-13 | Kyowa Hakko Kogyo Co Ltd | 特定部位に集積する化合物のスクリーニング方法 |
CA2517939C (en) | 2003-03-03 | 2015-11-24 | Dyax Corp. | Peptides that specifically bind hgf receptor (cmet) and uses thereof |
EP1635878B1 (de) * | 2003-06-25 | 2010-12-29 | Guerbet | Peptid-konjugat für die magnetresonanztomographie von matrix metalloproteinasen |
FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
NO20034350D0 (no) * | 2003-09-29 | 2003-09-29 | Amersham Health As | Optisk avbilding av kolorektal kreft |
US9695251B2 (en) | 2003-10-31 | 2017-07-04 | The Regents Of The University Of California | Activatable cell penetrating peptides with quenched fluorophores |
US7985401B2 (en) | 2003-10-31 | 2011-07-26 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
US7431915B2 (en) | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
NO20035683D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av prostatakreft |
NO20035682D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av ösofagkreft og Barretts ösofag |
NO20035681D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av lungekreft |
NO20035748D0 (no) * | 2003-12-19 | 2003-12-19 | Amersham Health As | Optisk avbildning av sårbar arteriosklerose |
US20070098631A2 (en) * | 2004-04-28 | 2007-05-03 | Guerbet | Diagnostic compounds comprising a scaffold coupled to a signal entity for medical imaging diagnostic |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281799A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US7766938B2 (en) * | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
EP1619501B1 (de) * | 2004-07-22 | 2007-09-26 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Cyanin-farbstoffen zur Diagnose von Krankheiten, welche mit Angiogenese assoziert sind |
GB0421308D0 (en) * | 2004-09-24 | 2004-10-27 | Amersham Plc | Enzyme inhibitor imaging agents |
KR20080009682A (ko) * | 2005-04-01 | 2008-01-29 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 킬레이트제인 폴리(펩티드): 제조 방법과 용도 |
CA2606270A1 (en) * | 2005-04-19 | 2006-10-26 | Massachusetts Institute Of Technology | Amphiphilic polymers and methods of use thereof |
WO2007030012A2 (en) * | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Extracellular matrix imaging |
US20070140974A1 (en) * | 2005-12-15 | 2007-06-21 | General Electric Company | Targeted nanoparticles for magnetic resonance imaging |
EP2510943B1 (de) | 2006-02-06 | 2016-04-20 | The Burnham Institute for Medical Research | Verfahren und Zusammensetzungen in Verbindung mit Targeting von Tumoren und Wunden |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
WO2008136869A2 (en) | 2006-12-06 | 2008-11-13 | Burnham Institute For Medical Research | Methods and compositions related to targeting wounds, regenerating tissue, and tumors |
EP2117575A4 (de) | 2007-01-03 | 2013-06-05 | Burnham Inst Medical Research | Verfahren und zusammensetzungen in verbindung mit gerinnselbindenden verbindungen |
DE102007036570A1 (de) * | 2007-08-03 | 2009-02-19 | Siemens Ag | Screeningtest zur Erkennung von Prostataerkrankungen sowie Vorrichtung und Diagnosesubstanz zur Durchführung des Tests |
DE102007037008B4 (de) * | 2007-08-06 | 2015-09-10 | Siemens Aktiengesellschaft | Diagnosesubstanz zur Anwendung in einem Verfahren zur Bestimmung der Aggressivität eines Prostatatumors |
DE102007041836A1 (de) * | 2007-09-03 | 2009-03-05 | Siemens Ag | Verfahren zur Abbildung eines Prostatatumors und dafür geeignetes Kontrastmittel |
US20090074672A1 (en) * | 2007-09-17 | 2009-03-19 | Sri International | Tumor Boundary Imaging |
JP2010538798A (ja) | 2007-09-19 | 2010-12-16 | オンコフルーア インコーポレイテッド | 臓器および組織を撮像および処置するための方法 |
US20100143258A1 (en) * | 2008-12-05 | 2010-06-10 | General Electric Company | Tumor margin imaging agents |
US8753604B2 (en) * | 2008-12-23 | 2014-06-17 | Sanford-Burnham Medical Research Institute | Methods and compositions for synaphically-targeted treatment for cancer |
EP2374002A1 (de) | 2008-12-23 | 2011-10-12 | GE Healthcare UK Limited | Anwendung einer auf 99mtc-peptid basierenden verbindung als knochenmark-bildgebungsmittel |
US11096901B2 (en) | 2009-03-06 | 2021-08-24 | Metaqor Llc | Dynamic bio-nanoparticle platforms |
US11235062B2 (en) * | 2009-03-06 | 2022-02-01 | Metaqor Llc | Dynamic bio-nanoparticle elements |
EP2454271A4 (de) | 2009-07-15 | 2015-08-12 | Univ California | Peptide mit steuerbarer zellulärer aufnahme |
WO2011043980A1 (en) | 2009-10-07 | 2011-04-14 | Sanford Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
WO2011049964A1 (en) | 2009-10-19 | 2011-04-28 | Lab Scientific Group | Rna detection and quantitation |
US8912136B2 (en) | 2009-12-18 | 2014-12-16 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding compounds |
EP2515944B1 (de) | 2009-12-23 | 2020-04-22 | Sanford-Burnham Medical Research Institute | Verfahren und zusammensetzungen im zusammenhang mit annexin 1-bindenden verbindungen |
JP2013525285A (ja) | 2010-04-08 | 2013-06-20 | サンフォード−バーナム メディカル リサーチ インスティテュート | 化合物の送達を増強するための方法および組成物 |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
EP2717909B1 (de) | 2011-06-04 | 2017-12-06 | Rochester General Hospital Research Institute | Zusammensetzungen und verfahren in zusammenhang mit p6 von haemophilus influenzae |
US20140308342A1 (en) * | 2011-11-11 | 2014-10-16 | Yale University | Reprogramming urokinase into an antibody-recruiting anticancer agent |
WO2014120837A2 (en) | 2013-01-29 | 2014-08-07 | The Regents Of The University Of California | Pretargeted activatable cell penetrating peptide with intracellulary releaseable prodrug |
KR102278630B1 (ko) | 2013-01-30 | 2021-07-16 | 아벨라스 바이오사이언시즈 인코포레이티드 | 선택적 전달 분자 및 사용 방법 |
US20170151339A1 (en) * | 2014-06-30 | 2017-06-01 | Tarveda Therapeutics, Inc. | Targeted conjugates and particles and formulations thereof |
WO2016041558A1 (en) * | 2014-09-17 | 2016-03-24 | Rigshospitalet | Upar targeting peptide for use in peroperative optical imaging of invasive cancer |
US10385380B2 (en) | 2014-10-02 | 2019-08-20 | The Regents Of The University Of California | Personalized protease assay to measure protease activity in neoplasms |
EP3037820A1 (de) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Zellerkennungsverfahren und Reagenzien mit lösbarem Etikettierungsteil |
WO2016149363A1 (en) * | 2015-03-16 | 2016-09-22 | Northwestern University | Contrast-agent-labeled peptide amphiphile nanofibers |
US10596259B2 (en) | 2015-05-20 | 2020-03-24 | The Regents Of The University Of California | Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof |
US10548881B2 (en) | 2016-02-23 | 2020-02-04 | Tarveda Therapeutics, Inc. | HSP90 targeted conjugates and particles and formulations thereof |
EP3490615A4 (de) * | 2016-07-27 | 2020-04-01 | The Trustees of Columbia University in the City of New York | Gelgebundene zusammensetzungen für strahlentherapie und verwendungen davon |
EP3412303A1 (de) | 2017-06-08 | 2018-12-12 | Medizinische Universität Innsbruck | Verbessertes pharmakokinetik- und cholecystokinin-2-rezeptor (cck2r)-zielverfahren für diagnose und therapie |
EP3941580A1 (de) | 2019-03-22 | 2022-01-26 | Reflexion Pharmaceuticals, Inc. | D-peptidische verbindungen für vegf |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
EP0436005B1 (de) * | 1989-07-20 | 1995-03-29 | Sandoz Ltd. | Markierte polypeptidderivate |
US5183900A (en) | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
DK0627940T3 (da) | 1992-03-05 | 2003-09-01 | Univ Texas | Anvendelse af immunokonjugater til diagnose og/eller terapi af vaskulariserede tumorer |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
CN1173991C (zh) * | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US5512591A (en) * | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
JP3670309B2 (ja) * | 1993-04-01 | 2005-07-13 | 第一製薬株式会社 | 二環性複素環化合物 |
US5480970A (en) | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
GB9502065D0 (en) * | 1995-02-02 | 1995-03-22 | Nycomed Imaging As | Contrast media |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
DE19522774A1 (de) * | 1995-06-27 | 1997-01-02 | Ifu Gmbh | Einrichtung zur spektroskopischen Untersuchung von Proben, die dem menschlichen Körper entnommen wurden |
AU719434B2 (en) * | 1996-02-13 | 2000-05-11 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
AU735900B2 (en) * | 1996-03-12 | 2001-07-19 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
ATE227268T1 (de) * | 1996-04-10 | 2002-11-15 | Merck & Co Inc | Alpha v beta 3 antagonisten |
ES2206689T3 (es) * | 1996-10-28 | 2004-05-16 | Amersham Health As | Agentes de contraste. |
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
WO1998039469A1 (en) * | 1997-03-04 | 1998-09-11 | Bio-Technology General Corp. | Isolation of tissue specific peptide ligands and their use for targeting pharmaceuticals to organs |
EP1056773A2 (de) | 1998-02-11 | 2000-12-06 | Resolution Pharmaceuticals Inc. | Für angiogenese spezifische moleküle |
-
1997
- 1997-04-24 GB GBGB9708265.5A patent/GB9708265D0/en active Pending
-
1998
- 1998-04-24 AT AT98917461T patent/ATE270116T1/de not_active IP Right Cessation
- 1998-04-24 DK DK04007226T patent/DK1442751T3/da active
- 1998-04-24 AT AT04007226T patent/ATE365054T1/de not_active IP Right Cessation
- 1998-04-24 DE DE69824842T patent/DE69824842T2/de not_active Expired - Lifetime
- 1998-04-24 ES ES98917461T patent/ES2224379T3/es not_active Expired - Lifetime
- 1998-04-24 ES ES04007226T patent/ES2287599T3/es not_active Expired - Lifetime
- 1998-04-24 EP EP04007226A patent/EP1442751B1/de not_active Expired - Lifetime
- 1998-04-24 JP JP54530798A patent/JP4993419B2/ja not_active Expired - Fee Related
- 1998-04-24 WO PCT/GB1998/001197 patent/WO1998047541A1/en active IP Right Grant
- 1998-04-24 AU AU70687/98A patent/AU7068798A/en not_active Abandoned
- 1998-04-24 DE DE69837975T patent/DE69837975T2/de not_active Expired - Lifetime
- 1998-04-24 EP EP98917461A patent/EP0977600B1/de not_active Expired - Lifetime
-
1999
- 1999-10-22 US US09/422,977 patent/US6610269B1/en not_active Expired - Fee Related
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2003
- 2003-06-17 US US10/462,836 patent/US7413727B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7413727B2 (en) | 2008-08-19 |
DK1442751T3 (da) | 2007-09-24 |
JP2002511845A (ja) | 2002-04-16 |
ATE270116T1 (de) | 2004-07-15 |
AU7068798A (en) | 1998-11-13 |
EP1442751B1 (de) | 2007-06-20 |
EP0977600A2 (de) | 2000-02-09 |
US6610269B1 (en) | 2003-08-26 |
US20040009122A1 (en) | 2004-01-15 |
EP0977600B1 (de) | 2004-06-30 |
JP4993419B2 (ja) | 2012-08-08 |
ATE365054T1 (de) | 2007-07-15 |
ES2224379T3 (es) | 2005-03-01 |
DE69824842T2 (de) | 2005-11-17 |
GB9708265D0 (en) | 1997-06-18 |
ES2287599T3 (es) | 2007-12-16 |
DE69837975T2 (de) | 2008-02-28 |
DE69837975D1 (de) | 2007-08-02 |
WO1998047541A1 (en) | 1998-10-29 |
EP1442751A1 (de) | 2004-08-04 |
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