DE69713597T2 - Zusammensetzungen enthaltend eine kombination von knochenmorphogenetischem protein und parathyroid-ähnlichem peptid - Google Patents

Zusammensetzungen enthaltend eine kombination von knochenmorphogenetischem protein und parathyroid-ähnlichem peptid

Info

Publication number
DE69713597T2
DE69713597T2 DE69713597T DE69713597T DE69713597T2 DE 69713597 T2 DE69713597 T2 DE 69713597T2 DE 69713597 T DE69713597 T DE 69713597T DE 69713597 T DE69713597 T DE 69713597T DE 69713597 T2 DE69713597 T2 DE 69713597T2
Authority
DE
Germany
Prior art keywords
proteins
compositions
combination
bone morphogenetic
parathyroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69713597T
Other languages
English (en)
Other versions
DE69713597D1 (de
Inventor
Gary Hattersley
A Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE69713597D1 publication Critical patent/DE69713597D1/de
Application granted granted Critical
Publication of DE69713597T2 publication Critical patent/DE69713597T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
DE69713597T 1996-03-26 1997-03-17 Zusammensetzungen enthaltend eine kombination von knochenmorphogenetischem protein und parathyroid-ähnlichem peptid Expired - Lifetime DE69713597T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/622,101 US5700774A (en) 1996-03-26 1996-03-26 Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
PCT/US1997/004162 WO1997035607A1 (en) 1996-03-26 1997-03-17 Methods of tissue induction using a combination of bone morphogenetic protein and parathyroid hormone-related peptide

Publications (2)

Publication Number Publication Date
DE69713597D1 DE69713597D1 (de) 2002-08-01
DE69713597T2 true DE69713597T2 (de) 2003-02-20

Family

ID=24492945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69713597T Expired - Lifetime DE69713597T2 (de) 1996-03-26 1997-03-17 Zusammensetzungen enthaltend eine kombination von knochenmorphogenetischem protein und parathyroid-ähnlichem peptid

Country Status (12)

Country Link
US (2) US5700774A (de)
EP (1) EP0906120B1 (de)
JP (1) JP2000507944A (de)
KR (1) KR19990087489A (de)
AT (1) ATE219685T1 (de)
AU (1) AU727312B2 (de)
CA (1) CA2249212A1 (de)
DE (1) DE69713597T2 (de)
FI (1) FI981916A0 (de)
NO (1) NO984345L (de)
OA (1) OA10885A (de)
WO (1) WO1997035607A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
GB9721797D0 (en) * 1997-10-14 1997-12-17 Univ Cardiff Materials and methods relating to cartilage repair
EP1034269A1 (de) 1997-11-28 2000-09-13 Roche Diagnostics GmbH Aktive hedgehog-protein-mutante, verfahren zur herstellung und verwendung als arzneimittel
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
US6171340B1 (en) 1998-02-27 2001-01-09 Mcdowell Charles L. Method and device for regenerating cartilage in articulating joints
DE69928040T2 (de) * 1998-04-30 2006-07-27 Curis, Inc., Cambridge Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
WO2000002905A2 (en) 1998-07-13 2000-01-20 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) * 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US7067144B2 (en) * 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
DE60036863T2 (de) 1999-03-25 2008-07-31 Metabolix, Inc., Cambridge Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
US6315992B1 (en) 1999-06-30 2001-11-13 Tissuegene Co. Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
US7338655B1 (en) 1999-06-30 2008-03-04 Tissuegene, Inc. Gene therapy using TGF-β
KR20080099355A (ko) * 1999-07-21 2008-11-12 오메로스 코포레이션 동통, 염증 및 연골 퇴화를 억제하기 위한 용액 및 억제방법
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US7635390B1 (en) 2000-01-14 2009-12-22 Marctec, Llc Joint replacement component having a modular articulating surface
US6770078B2 (en) 2000-01-14 2004-08-03 Peter M. Bonutti Movable knee implant and methods therefor
US6702821B2 (en) 2000-01-14 2004-03-09 The Bonutti 2003 Trust A Instrumentation for minimally invasive joint replacement and methods for using same
WO2002013865A1 (fr) * 2000-08-16 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Agents destines a soulager les symptomes provoques par des maladies articulaires
US7708741B1 (en) 2001-08-28 2010-05-04 Marctec, Llc Method of preparing bones for knee replacement surgery
US7476257B2 (en) 2001-09-15 2009-01-13 Rush University Medical Center Methods to engineer stratified cartilage tissue
WO2003028655A2 (en) * 2001-10-04 2003-04-10 Massachusetts Institute Of Technology Effect of bone morphogenetic proteins on engineered cartilage
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
US7015195B2 (en) * 2002-01-10 2006-03-21 Osteotrophin, Llc Treatment of bone disorders with skeletal anabolic drugs
EP1485487A4 (de) * 2002-03-12 2005-11-09 Tissuegene Inc Knorpelregeneration mit chondrozyt und tgf-beta
US7005127B2 (en) * 2002-03-29 2006-02-28 Tissuegene, Inc. Mixed-cell gene therapy
US7431922B2 (en) * 2002-03-29 2008-10-07 Tissuegene, Inc. Bioadhesive directed somatic cell therapy
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
EP1542711A4 (de) * 2002-08-13 2009-07-01 Wyeth Corp Peptide als solubilisierende hilfsstoffe zur umwandlung von wachstumsfaktor-proteinen
US20050209142A1 (en) * 2002-11-20 2005-09-22 Goran Bertilsson Compounds and methods for increasing neurogenesis
US7837690B2 (en) 2003-01-15 2010-11-23 Biomet Manufacturing Corp. Method and apparatus for less invasive knee resection
US7887542B2 (en) 2003-01-15 2011-02-15 Biomet Manufacturing Corp. Method and apparatus for less invasive knee resection
US7789885B2 (en) 2003-01-15 2010-09-07 Biomet Manufacturing Corp. Instrumentation for knee resection
US8551100B2 (en) 2003-01-15 2013-10-08 Biomet Manufacturing, Llc Instrumentation for knee resection
CA2520460A1 (en) * 2003-03-27 2004-10-14 Children's Hospital Medical Center Use of fgf- 18 protein, target proteins and their respective encoding nucleotide sequences to induce cartilage formation
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US7488324B1 (en) 2003-12-08 2009-02-10 Biomet Manufacturing Corporation Femoral guide for implanting a femoral knee prosthesis
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
JP2008530227A (ja) 2005-02-16 2008-08-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨状態を治療または予防する薬剤組成物
US7695479B1 (en) 2005-04-12 2010-04-13 Biomet Manufacturing Corp. Femoral sizer
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP2009502782A (ja) 2005-07-18 2009-01-29 アコロジックス インコーポレイティッド 硬組織形成を促進するためのタンパク質製剤
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US7780672B2 (en) 2006-02-27 2010-08-24 Biomet Manufacturing Corp. Femoral adjustment device and associated method
US9918740B2 (en) 2006-02-27 2018-03-20 Biomet Manufacturing, Llc Backup surgical instrument system and method
US9345548B2 (en) 2006-02-27 2016-05-24 Biomet Manufacturing, Llc Patient-specific pre-operative planning
US8070752B2 (en) 2006-02-27 2011-12-06 Biomet Manufacturing Corp. Patient specific alignment guide and inter-operative adjustment
US20150335438A1 (en) 2006-02-27 2015-11-26 Biomet Manufacturing, Llc. Patient-specific augments
US8603180B2 (en) 2006-02-27 2013-12-10 Biomet Manufacturing, Llc Patient-specific acetabular alignment guides
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US10278711B2 (en) 2006-02-27 2019-05-07 Biomet Manufacturing, Llc Patient-specific femoral guide
US9113971B2 (en) 2006-02-27 2015-08-25 Biomet Manufacturing, Llc Femoral acetabular impingement guide
US9173661B2 (en) 2006-02-27 2015-11-03 Biomet Manufacturing, Llc Patient specific alignment guide with cutting surface and laser indicator
US9289253B2 (en) 2006-02-27 2016-03-22 Biomet Manufacturing, Llc Patient-specific shoulder guide
US9907659B2 (en) 2007-04-17 2018-03-06 Biomet Manufacturing, Llc Method and apparatus for manufacturing an implant
US9339278B2 (en) 2006-02-27 2016-05-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
US8407067B2 (en) 2007-04-17 2013-03-26 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US7695520B2 (en) 2006-05-31 2010-04-13 Biomet Manufacturing Corp. Prosthesis and implementation system
US9795399B2 (en) 2006-06-09 2017-10-24 Biomet Manufacturing, Llc Patient-specific knee alignment guide and associated method
AU2008209473B2 (en) * 2007-01-22 2012-10-25 Orthotrophix, Inc. A peptide composition and a method of promoting cartilage formation
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP2265220A1 (de) 2008-03-05 2010-12-29 Musculoskeletal Transplant Foundation Spongiosa-konstrukte, knorpelteilchen und kombinationen von spongiosa-konstrukten und knorpelteilchen
WO2010045229A2 (en) 2008-10-13 2010-04-22 University Of Rochester Protecting and repairing cartilage and musculoskeletal soft tissues
KR20110089876A (ko) 2008-11-25 2011-08-09 티슈진, 인코포레이티드 감작 세포 치료요법
US8530420B2 (en) * 2008-12-16 2013-09-10 Kaohsiung Medical University Treatment of arthritis with parathyroid hormone
US9968376B2 (en) 2010-11-29 2018-05-15 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9241745B2 (en) 2011-03-07 2016-01-26 Biomet Manufacturing, Llc Patient-specific femoral version guide
CA2918486C (en) * 2012-07-20 2020-12-08 The Regents Of The University Of California Methods for producing cartilage and bone
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2018144719A1 (en) * 2017-02-01 2018-08-09 The Johns Hopkins University Parathyroid hormone and regeneration of degenerative discs disease
US10722310B2 (en) 2017-03-13 2020-07-28 Zimmer Biomet CMF and Thoracic, LLC Virtual surgery planning system and method

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5457092A (en) * 1987-07-30 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
WO1990010067A1 (de) * 1989-02-23 1990-09-07 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung
DE69132823T2 (de) * 1990-05-16 2002-07-18 Genetics Inst Knochen- und knorpel-bildung hervorrufende proteine
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
ATE142460T1 (de) * 1991-06-21 1996-09-15 Genetics Inst Osteogene proteine enthaltende arzneimittel
ES2127757T3 (es) * 1991-06-25 1999-05-01 Genetics Inst Composiciones bmp-9.
JP3504263B2 (ja) * 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
ES2141761T3 (es) * 1992-02-12 2000-04-01 Bioph Biotech Entw Pharm Gmbh Secuencias de dna codificantes de nuevos factores de crecimiento/diferenciacion.
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
JP3645258B2 (ja) * 1993-01-12 2005-05-11 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−5
WO1994015966A1 (en) * 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-9
JPH08505771A (ja) * 1993-01-12 1996-06-25 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−3
EP1333035A3 (de) * 1993-03-19 2004-07-07 The Johns Hopkins University School Of Medicine Wachstumsdifferenzierungsfaktor-8
EP1378572B1 (de) * 1993-05-12 2006-10-25 Genetics Institute, LLC BMP-11 Zusammenstellungen
ATE265529T1 (de) * 1993-05-12 2004-05-15 Inst Genetics Llc Bmp-10 zusammensetzungen
US5986058A (en) * 1993-07-09 1999-11-16 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-7 and protein encoded thereby
CA2165776A1 (en) * 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-6
JP3717930B2 (ja) * 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Bmp−12、bmp−13およびそれらの腱誘導組成物

Also Published As

Publication number Publication date
EP0906120A1 (de) 1999-04-07
ATE219685T1 (de) 2002-07-15
EP0906120B1 (de) 2002-06-26
NO984345D0 (no) 1998-09-18
AU727312B2 (en) 2000-12-07
FI981916A (fi) 1998-09-08
FI981916A0 (fi) 1998-09-08
NO984345L (no) 1998-09-18
CA2249212A1 (en) 1997-10-02
DE69713597D1 (de) 2002-08-01
OA10885A (en) 2003-02-18
US5700774A (en) 1997-12-23
AU2329097A (en) 1997-10-17
WO1997035607A1 (en) 1997-10-02
KR19990087489A (ko) 1999-12-27
JP2000507944A (ja) 2000-06-27
US5846931A (en) 1998-12-08

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