DE69530283T2 - Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen - Google Patents

Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen Download PDF

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Publication number
DE69530283T2
DE69530283T2 DE69530283T DE69530283T DE69530283T2 DE 69530283 T2 DE69530283 T2 DE 69530283T2 DE 69530283 T DE69530283 T DE 69530283T DE 69530283 T DE69530283 T DE 69530283T DE 69530283 T2 DE69530283 T2 DE 69530283T2
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DE
Germany
Prior art keywords
cells
electrodes
drugs
genes
blood vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69530283T
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English (en)
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DE69530283D1 (de
Inventor
Gunter A Hofmann
Lois J Crandell
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Genetronics Inc
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Genetronics Inc
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Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Publication of DE69530283D1 publication Critical patent/DE69530283D1/de
Application granted granted Critical
Publication of DE69530283T2 publication Critical patent/DE69530283T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
DE69530283T 1994-01-21 1995-01-20 Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen Expired - Lifetime DE69530283T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/183,963 US5507724A (en) 1992-07-01 1994-01-21 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
PCT/US1995/000799 WO1995019805A1 (en) 1994-01-21 1995-01-20 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells

Publications (2)

Publication Number Publication Date
DE69530283D1 DE69530283D1 (de) 2003-05-15
DE69530283T2 true DE69530283T2 (de) 2004-01-29

Family

ID=22675037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530283T Expired - Lifetime DE69530283T2 (de) 1994-01-21 1995-01-20 Elektroporation und iontophorese vorrichtung für die abgabe von medikamenten und genen in zellen

Country Status (11)

Country Link
US (1) US5507724A (de)
EP (1) EP0740564B1 (de)
JP (1) JP3223321B2 (de)
AT (1) ATE236681T1 (de)
AU (1) AU1605295A (de)
CA (1) CA2177655C (de)
DE (1) DE69530283T2 (de)
DK (1) DK0740564T3 (de)
ES (1) ES2196057T3 (de)
PT (1) PT740564E (de)
WO (1) WO1995019805A1 (de)

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AU1605295A (en) 1995-08-08
DE69530283D1 (de) 2003-05-15
ATE236681T1 (de) 2003-04-15
JPH09511385A (ja) 1997-11-18
JP3223321B2 (ja) 2001-10-29
EP0740564A1 (de) 1996-11-06
ES2196057T3 (es) 2003-12-16
US5507724A (en) 1996-04-16
CA2177655A1 (en) 1995-07-27
PT740564E (pt) 2003-08-29
CA2177655C (en) 2001-09-25
WO1995019805A1 (en) 1995-07-27
DK0740564T3 (da) 2003-07-28
EP0740564B1 (de) 2003-04-09

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