DE69516311D1 - Hämolyse vorbeugung durch tenside - Google Patents

Hämolyse vorbeugung durch tenside

Info

Publication number
DE69516311D1
DE69516311D1 DE69516311T DE69516311T DE69516311D1 DE 69516311 D1 DE69516311 D1 DE 69516311D1 DE 69516311 T DE69516311 T DE 69516311T DE 69516311 T DE69516311 T DE 69516311T DE 69516311 D1 DE69516311 D1 DE 69516311D1
Authority
DE
Germany
Prior art keywords
pct
surfactants
emulsion
sec
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69516311T
Other languages
English (en)
Other versions
DE69516311T2 (de
Inventor
Timothy Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of DE69516311D1 publication Critical patent/DE69516311D1/de
Application granted granted Critical
Publication of DE69516311T2 publication Critical patent/DE69516311T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
DE69516311T 1994-12-23 1995-12-15 Hämolyse vorbeugung durch tenside Expired - Fee Related DE69516311T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426104.7A GB9426104D0 (en) 1994-12-23 1994-12-23 Use of surfactants and emulsions
PCT/GB1995/002936 WO1996019970A1 (en) 1994-12-23 1995-12-15 Hemolysis prevention by surfactants and emulsions

Publications (2)

Publication Number Publication Date
DE69516311D1 true DE69516311D1 (de) 2000-05-18
DE69516311T2 DE69516311T2 (de) 2000-11-09

Family

ID=10766511

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69516311T Expired - Fee Related DE69516311T2 (de) 1994-12-23 1995-12-15 Hämolyse vorbeugung durch tenside

Country Status (9)

Country Link
US (1) US5880123A (de)
EP (1) EP0799026B1 (de)
JP (1) JPH10511382A (de)
AT (1) ATE191645T1 (de)
AU (1) AU714121B2 (de)
DE (1) DE69516311T2 (de)
ES (1) ES2144648T3 (de)
GB (1) GB9426104D0 (de)
WO (1) WO1996019970A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759641B2 (en) * 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
IN188843B (de) * 2000-06-22 2002-11-09 Vinod Daftary Gautam Dr
AU2002218535A1 (en) * 2000-12-12 2002-06-24 Japan Tobacco Inc. Pharmaceutical composition containing an active with a hemolytic action and a surfactant
US6982256B2 (en) 2001-09-07 2006-01-03 Boehringer Ingelheim Pharma Kg Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
DE10144030A1 (de) * 2001-09-07 2003-03-27 Boehringer Ingelheim Pharma Verbesserung der lokalen Verträglichkeit bei intravenöser Verabreichung von 4-(4-(2-Pyrrolylcarbonyl-1-piperazinyl)-3-trifluormethyl-benzoylguanidin
DE102006029573A1 (de) 2006-06-22 2007-12-27 Bayer Schering Pharma Ag Neue Quinazoline als Kinase-Inhibitoren
WO2010020052A1 (en) * 2008-08-21 2010-02-25 Edouard Kouassi Methods and compounds for increasing red blood cell survival

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
JPS5919525B2 (ja) * 1976-09-03 1984-05-07 武田薬品工業株式会社 注射剤
JPS6117512A (ja) * 1984-07-03 1986-01-25 Ss Pharmaceut Co Ltd 低溶血性ビタミンｅ注射液
JPS6336826A (ja) * 1986-07-30 1988-02-17 Shiseido Co Ltd 可溶化組成物
JPH03106812A (ja) * 1989-09-16 1991-05-07 Shiseido Co Ltd 注射剤用低刺激性組成物
JPH07173079A (ja) * 1992-12-22 1995-07-11 Nippon Oil & Fats Co Ltd 両親媒性ポリエチレングリコール誘導体および用途
JP3534199B2 (ja) * 1993-11-10 2004-06-07 株式会社薬研 界面活性剤組成物
DE69434063D1 (de) * 1993-12-29 2004-11-11 Merck Sharp & Dohme Substituierte Morpholinderivate und ihre Verwendung als therapeutische Mittel

Also Published As

Publication number Publication date
EP0799026B1 (de) 2000-04-12
ES2144648T3 (es) 2000-06-16
AU714121B2 (en) 1999-12-16
ATE191645T1 (de) 2000-04-15
DE69516311T2 (de) 2000-11-09
US5880123A (en) 1999-03-09
JPH10511382A (ja) 1998-11-04
AU4185996A (en) 1996-07-19
EP0799026A1 (de) 1997-10-08
WO1996019970A1 (en) 1996-07-04
GB9426104D0 (en) 1995-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee