DE69430384D1 - Nukleinsäurevermittelter elektronentransfer - Google Patents

Nukleinsäurevermittelter elektronentransfer

Info

Publication number
DE69430384D1
DE69430384D1 DE69430384T DE69430384T DE69430384D1 DE 69430384 D1 DE69430384 D1 DE 69430384D1 DE 69430384 T DE69430384 T DE 69430384T DE 69430384 T DE69430384 T DE 69430384T DE 69430384 D1 DE69430384 D1 DE 69430384D1
Authority
DE
Germany
Prior art keywords
nucleic acid
complexes
electron transfer
acid mediated
mediated electron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430384T
Other languages
English (en)
Other versions
DE69430384T2 (de
Inventor
J Meade
F Kayyem
E Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22601539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69430384(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of DE69430384D1 publication Critical patent/DE69430384D1/de
Application granted granted Critical
Publication of DE69430384T2 publication Critical patent/DE69430384T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69430384T 1993-12-10 1994-12-05 Nukleinsäurevermittelter elektronentransfer Expired - Lifetime DE69430384T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/166,036 US5591578A (en) 1993-12-10 1993-12-10 Nucleic acid mediated electron transfer
PCT/US1994/013893 WO1995015971A2 (en) 1993-12-10 1994-12-05 Nucleic acid mediated electron transfer

Publications (2)

Publication Number Publication Date
DE69430384D1 true DE69430384D1 (de) 2002-05-16
DE69430384T2 DE69430384T2 (de) 2002-12-12

Family

ID=22601539

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430384T Expired - Lifetime DE69430384T2 (de) 1993-12-10 1994-12-05 Nukleinsäurevermittelter elektronentransfer

Country Status (10)

Country Link
US (6) US5591578A (de)
EP (2) EP0733058B1 (de)
JP (2) JPH09506510A (de)
AT (1) ATE215959T1 (de)
AU (1) AU703329B2 (de)
CA (1) CA2178618A1 (de)
DE (1) DE69430384T2 (de)
DK (1) DK0733058T3 (de)
ES (1) ES2174917T3 (de)
WO (1) WO1995015971A2 (de)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69132843T2 (de) * 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identifizierung von Nukleinsäuren in Proben
ATE319853T1 (de) * 1992-11-27 2006-03-15 Canon Kk Verfahren und sonde zum nachweis von nukleinsäuren
US5824473A (en) * 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6028190A (en) * 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
EP0684239B1 (de) * 1994-05-26 2003-12-10 Canon Kabushiki Kaisha Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6361951B1 (en) * 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
DE19525632C2 (de) * 1995-07-14 1997-07-17 Bag Biolog Analysensystem Gmbh Sequenzspezifisches Nukleinsäurenachweisverfahren und Reagenz-System zu dessen Durchführung
ATE308553T1 (de) * 1996-06-07 2005-11-15 Amersham Biosciences Sv Corp Nukleinsäurevermittelter elektronentransfer
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
EP0837141B1 (de) 1996-10-03 2003-01-08 Canon Kabushiki Kaisha Verfahren zur Detektion von Zielnukleinsäure, Verfahren zu ihrer Quantifizierung und Pyrylium-Verbindungen zur Chemilumineszenz-Analyse
GB2333597B (en) * 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
US5874046A (en) * 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
AU739375B2 (en) * 1996-11-05 2001-10-11 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6001570A (en) * 1997-02-18 1999-12-14 Invitro Diagnostics, Inc. Compositions, methods, kits and apparatus for determining the presence or absence of target molecules
AU6822598A (en) * 1997-02-24 1998-09-09 Georgia Tech Research Corporation Method for determining a nucleic acid
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US6649350B2 (en) 1997-04-09 2003-11-18 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6221586B1 (en) 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US6699667B2 (en) 1997-05-14 2004-03-02 Keensense, Inc. Molecular wire injection sensors
US7220550B2 (en) * 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
US7560237B2 (en) 1997-06-12 2009-07-14 Osmetech Technology Inc. Electronics method for the detection of analytes
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6203983B1 (en) * 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
IL121312A (en) * 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
US6031098A (en) 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
AU9393398A (en) * 1997-09-16 1999-04-05 Egea Biosciences, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
CA2229386A1 (en) * 1997-12-16 1999-06-16 The University Of Saskatchewan Conductive metal-containing nucleic acids
JP2002508386A (ja) * 1997-12-16 2002-03-19 ザ・ユニバーシティー・オブ・サスカチワン・テクノロジーズ・インコーポレーテッド 導電性金属含有核酸
US6200752B1 (en) * 1998-01-14 2001-03-13 Joseph R. Lakowicz Method and composition for detecting the presence of a nucleic acid sequence in a sample
AU2559599A (en) * 1998-01-20 1999-08-02 Bruce Parkinson Detection of genetic information
US6063573A (en) * 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
JP2002500897A (ja) 1998-01-27 2002-01-15 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
DE69939629D1 (de) * 1998-05-05 2008-11-06 Massachusetts Inst Technology Emittierende Polymere und Vorrichtungen diese Polymere enthaltend
EP1075549B1 (de) 1998-05-06 2008-09-03 Clinical Micro Sensors, Inc. Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6180350B1 (en) * 1998-05-26 2001-01-30 Georgia University Research Foundation Inc. Methods and apparatus for the photo-electrochemical detection of nucleic acid
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6288221B1 (en) 1998-08-20 2001-09-11 Duke University Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
AU5492499A (en) * 1998-08-21 2000-03-14 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
WO2000024941A1 (en) * 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
DE19964220C2 (de) 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
US7160869B2 (en) * 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
DE19860547C1 (de) * 1998-12-23 2000-10-12 Genetrix B V I O Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6468785B1 (en) * 1999-02-19 2002-10-22 New Mexico State University Technology Transfer Corporation Doped conducting polymers applications and methods
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
CA2370123C (en) 1999-05-03 2010-09-14 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of actinomycetes
AU5267800A (en) 1999-05-03 2000-11-17 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae
US6821770B1 (en) * 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6376186B1 (en) 1999-05-03 2002-04-23 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of staphylococcus
EP1925678B1 (de) 1999-05-03 2009-07-22 Gen-Probe Incorporated Polynukleotidmatrix-basiertes Verfahren zur Identifizierung von Mikroorganismen
AU5459000A (en) * 1999-06-03 2000-12-28 Lockheed Martin Corporation Highly sensitive biological agent probe
US6399305B1 (en) * 1999-06-07 2002-06-04 Fuji Photo Film Co., Ltd. Protection of partial complementary nucleic acid fragment using a electroconductive chip and intercalator
WO2001007665A2 (en) 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
DE19938138C2 (de) * 1999-08-16 2003-02-13 November Ag Molekulare Medizin Verfahren und Vorrichtung zur Identifikation einer Biopolymersequenz auf Festkörperoberflächen
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
DE19960076C2 (de) * 1999-12-13 2002-12-05 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
JP2003525449A (ja) * 2000-03-01 2003-08-26 ノヴェンバー アクティエンゲゼルシャフト ゲゼルシャフト フューア モレクラーレ メディツィーン 液体中に存在する標的分子の定量
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US6677606B1 (en) * 2000-06-28 2004-01-13 University Of Chicago Dopa and dopamine modification of metal oxide semiconductors, method for attaching biological molecules to semiconductors
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
US6783814B2 (en) 2000-08-21 2004-08-31 Massachusetts Institute Of Technology Polymers with high internal free volume
US6787339B1 (en) 2000-10-02 2004-09-07 Motorola, Inc. Microfluidic devices having embedded metal conductors and methods of fabricating said devices
AU2002241803A1 (en) * 2000-10-20 2002-06-18 The Board Of Trustees Of The Leland Stanford Junior University Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
AU3054502A (en) 2000-10-23 2002-05-06 Gen Probe Inc Compositions and methods for detecting human immunodeficiency virus 2 (hiv-2)
JP2004522739A (ja) * 2000-12-08 2004-07-29 カリフォルニア インスティテュート オブ テクノロジー ポリヌクレオチド二本鎖損傷を検出するための方法および組成物
DE60227361D1 (de) * 2001-01-19 2008-08-14 Centocor Inc Computer vermitteltes assembly von polynucleotiden kodierend für ein zielgerichtetes polypeptide
US20030003476A1 (en) * 2001-03-23 2003-01-02 Fuji Photo Film Co., Ltd. Waste water inspecting agent and waste water inspecting apparatus using the same
US7077982B2 (en) * 2001-03-23 2006-07-18 Fuji Photo Film Co., Ltd. Molecular electric wire, molecular electric wire circuit using the same and process for producing the molecular electric wire circuit
US20020168667A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Antigen detecting agent and antigen detecting kit, antigen detecting apparatus and antigen detecting method using the same
US20020168756A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Particle size variable reactor
US20020168291A1 (en) * 2001-03-23 2002-11-14 Fuji Photo Film Co., Ltd. Agent for health inspection and health inspection apparatus using the same
US7018795B2 (en) * 2001-03-23 2006-03-28 Fuji Photo Film Co., Ltd. Hybridization probe and target nucleic acid detecting kit, target nucleic acid detecting apparatus and target nucleic acid detecting method using the same
US7029919B2 (en) * 2001-05-04 2006-04-18 Agilent Technologies, Inc. Electro-optical device and methods for hybridization and detection
JP2004532527A (ja) * 2001-05-24 2004-10-21 ユニバーシティ・オブ・サスカチェワン・テクノロジーズ・インコーポレイテッド 核酸回路素子及び方法
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
JP2005515468A (ja) * 2001-08-20 2005-05-26 リジェネシス バイオリメディエイション プロダクツ 微分子の分析物のバイオセンサ
AU2002360272A1 (en) * 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US20040086924A1 (en) * 2001-10-26 2004-05-06 Research Development Foundation In vitro selection of signaling aptamers
JP2005508198A (ja) * 2001-11-06 2005-03-31 インテグレイティド ナノ−テクノロジーズ エルエルシー 試料中の生物物質を検出するためのシステム
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US6756223B2 (en) * 2001-12-18 2004-06-29 Motorola, Inc. Electro-chemical analysis device with integrated thermal sensor and method for monitoring a sample using the device
GB0205455D0 (en) * 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
US20030179381A1 (en) * 2002-03-18 2003-09-25 Fuji Photo Film Co., Ltd. Sensor, color sensor and apparatus for inspection using the same
US20030198960A1 (en) * 2002-04-01 2003-10-23 Wenhong Fan Signal amplifying targeted reporters for biological and chemical sensor applications
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
AU2003228649A1 (en) * 2002-04-23 2003-11-10 U.S.Genomics, Inc. Compositions and methods related to two-arm nucleic acid probes
US7785776B2 (en) 2002-05-13 2010-08-31 Idaho Technology, Inc. Genotyping by amplicon melting curve analysis
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
WO2004007634A2 (en) * 2002-07-15 2004-01-22 Massachusetts Institute Of Technology Emissive, high charge transport polymers
JP2005533256A (ja) * 2002-07-17 2005-11-04 ユー．エス． ジェノミクス， インコーポレイテッド キメラタグを用いるポリマーを分析するための方法と組成物
US20060110819A1 (en) * 2002-09-30 2006-05-25 Lomas Lee O Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces
EP3241915B1 (de) 2002-10-16 2021-06-23 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis des west-nil-viruses
JP4294946B2 (ja) * 2002-12-13 2009-07-15 富士フイルム株式会社 標的検出装置及び標的検出方法並びに標的検出用基材
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
EP1579516B1 (de) * 2002-12-23 2007-03-28 University of Saskatchewan Chemische schaltung von nukleinsäureschaltungselementen
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
WO2004111602A2 (en) * 2003-05-16 2004-12-23 University Of Rochester Colorimetric and fluorescent methods for sensing of oligonucleotides
US20060166249A1 (en) * 2003-05-16 2006-07-27 University Of Rochester Methods for separating short single-stranded nucleic acid from long single-and double-stranded nucleic acid, and associated biomolecular assays
US20100000881A1 (en) * 2003-10-30 2010-01-07 North Carolina State University Electrochemical detection of nucleic acid hybridization
JP4699384B2 (ja) 2003-12-19 2011-06-08 ジェン−プロウブ インコーポレイテッド Ｈｉｖ−１およびｈｉｖ−２の核酸を検出するための組成物、方法およびキット
US8617819B2 (en) * 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
US20060068380A1 (en) 2004-09-30 2006-03-30 Gen-Probe Incorporated Assay for detecting and quantifying HIV-1
CA2582661C (en) * 2004-11-09 2015-08-11 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
US20060205061A1 (en) * 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
CA2651815A1 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
WO2008019086A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Detection of explosives, toxins and other compositions
US8034563B1 (en) * 2006-09-12 2011-10-11 Steven Albert Benner Activated joining of nucleic acid probes
WO2008042289A2 (en) 2006-09-29 2008-04-10 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) * 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) * 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
EP1970378A1 (de) * 2007-03-16 2008-09-17 Universite Libre De Bruxelles Auf Oligonukleotiden verankerte lichtreaktive Ru (II)-Komplexe, Verfahren zu ihrer Gewinnung und ihre Verwendung
CA2691451C (en) * 2007-06-21 2015-03-24 Sara H. Fan Instrument and receptacles for performing processes
EP3957754A1 (de) 2008-04-21 2022-02-23 Gen-Probe Incorporated Verfahren zur erkennung des chikungunya-virus
US20100003765A1 (en) * 2008-05-13 2010-01-07 Pacific Biosciences Of California, Inc. Methods and systems for mitigating oxygen enhanced damage in real-time analytical operations
GB0900526D0 (en) * 2009-01-14 2009-02-11 Perkinelmer Ltd Fluorescence microscopy methods and apparatus
CA2750900C (en) 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
WO2010114599A1 (en) 2009-04-01 2010-10-07 Dx Terity Diagnostics Inc. Chemical ligation dependent probe amplification (clpa)
WO2012003289A1 (en) 2010-06-30 2012-01-05 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
EP3438289A1 (de) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
EP2710145B1 (de) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Verfahren und zusammensetzungen zum nachweis von zielnukleinsäuren
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
CA2889415C (en) 2012-10-24 2020-06-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
EP2969217A2 (de) 2013-03-15 2016-01-20 Genmark Diagnostics Inc. Systeme, verfahren und vorrichtung zur manipulation verformbarer flüssigkeitsgefässe
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
AU2015274660B2 (en) 2014-06-10 2020-07-16 Dxterity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
WO2016077364A2 (en) 2014-11-11 2016-05-19 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system
WO2018053501A1 (en) 2016-09-19 2018-03-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
EP4219771A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren für den multiplexnachweis viraler krankheitserreger in proben
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
EP3673086A1 (de) 2017-08-24 2020-07-01 Clinical Micro Sensors, Inc. (DBA GenMark Diagnostics, Inc.) Elektrochemischer nachweis von bakteriellen und / oder pilzinfektionen
WO2023237641A1 (en) 2022-06-07 2023-12-14 F. Hoffmann-La Roche Ag Ferrocene labelled primers for electrochemical detection

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5175269A (en) * 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US5002885A (en) * 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US4952685A (en) * 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5013831A (en) * 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5112974A (en) * 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
EP0235301B1 (de) * 1985-09-09 1992-07-22 Teijin Limited Pyridopyrimidin-nukleotid-abkömmlinge
US5595908A (en) * 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (en) * 1986-02-27 1989-05-30 Marco F. Cardosi Application of tetrathiafulvalenes in bioelectrochemical processes
DE3708767A1 (de) * 1987-03-18 1988-09-29 Hoechst Ag Wasserloesliche azoverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbstoffe
JPS63238166A (ja) * 1987-03-26 1988-10-04 Mitsubishi Electric Corp 有機電子素子材料
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US6153737A (en) * 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
CA2033692A1 (en) * 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
DE69125441T2 (de) * 1990-09-28 1997-11-06 Toshiba Kawasaki Kk Verfahren zum Gennachweis
DE4039677A1 (de) * 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5272056A (en) * 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
WO1993010267A1 (en) * 1991-11-15 1993-05-27 Igen, Inc. Rapid assays for amplification products
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
EP0566751B1 (de) * 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag Verfahren zum DNS-Nachweis
CA2094785A1 (en) * 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
JPH0641183A (ja) * 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
JPH06121404A (ja) * 1992-10-06 1994-04-28 Hitachi Ltd 電気車の制御装置
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
ATE319853T1 (de) * 1992-11-27 2006-03-15 Canon Kk Verfahren und sonde zum nachweis von nukleinsäuren
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) * 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
JP2000501601A (ja) * 1995-06-27 2000-02-15 ザ ユニヴァーシティ オブ ノース カロライナ アット チャペル ヒル 核酸ハイブリッド形成の電気化学的検出
WO1997044651A1 (en) * 1996-05-22 1997-11-27 Australian Membrane And Biotechnology Research Institute Nucleic acid sensor
EP0970375A2 (de) * 1997-02-06 2000-01-12 The University of North Carolina at Chapel Hill Elektrochemische sonde zum nachweis von molekularen interaktionen und zum auffinden von medikamenten
US6361671B1 (en) * 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

Also Published As

Publication number Publication date
CA2178618A1 (en) 1995-06-15
DK0733058T3 (da) 2002-08-05
US5780234A (en) 1998-07-14
DE69430384T2 (de) 2002-12-12
JP2005013222A (ja) 2005-01-20
US5591578A (en) 1997-01-07
WO1995015971A3 (en) 1995-08-03
EP1172446A3 (de) 2002-04-10
ATE215959T1 (de) 2002-04-15
AU1215295A (en) 1995-06-27
EP1172446A2 (de) 2002-01-16
ES2174917T3 (es) 2002-11-16
EP0733058B1 (de) 2002-04-10
AU703329B2 (en) 1999-03-25
US20010034033A1 (en) 2001-10-25
EP0733058A1 (de) 1996-09-25
JPH09506510A (ja) 1997-06-30
US5705348A (en) 1998-01-06
US6087100A (en) 2000-07-11
WO1995015971A2 (en) 1995-06-15
US6268149B1 (en) 2001-07-31

Similar Documents

Publication Publication Date Title
DE69430384D1 (de) Nukleinsäurevermittelter elektronentransfer
ATE238337T1 (de) Durch nukleinsäure vermittelter elektronen- transfer
DE69734520D1 (de) Nukleinsäurevermittelter elektronentransfer
ZA918965B (en) Nucleic acid amplification by two-enzyme,self-sustained sequence replication
NO791140L (no) Tioetiansyrederivater.
AU505135B2 (en) 2, 3-dihydrobenzofuran-2-carboxylic acid derivatives
DE3872937T2 (de) Benzoylaminophenoxybuttersaeure-derivate.
IE41383L (en) Piperidinylimidazolinone derivatives
ES370305A1 (es) Procedimiento para preparar composiciones pesticidas.
NL7902910A (nl) Gemodificeerd desoxyribonucleinezuur uit lambda-bacte- riofagen.
DE69018375D1 (de) Pro-drugs von 6-Mercaptopurin und 6-Thioguanin.
DE68913498T2 (de) 1,1-dioxo-cephem-4-carbothiolsäure-derivate.
NO884361D0 (no) Katechol-karboksylsyrederivater.
NO883233L (no) Hydrokanelsyrederivater.
IT8026355A0 (it) Composizioni a base di mercaptoorganosilossani, vulcanizzabili in presenza di ossigeno, contenenti sia composti redox che composti di ferrocarbonile, e metodo per la formazione di prodotti a peso molecolare superiore a partire da dette composizioni.
IT7819222A0 (it) Composizione contenente anidride maleica, ad elevato punto di rammollimento.
IL49718A (en) 7-( -amino- -(2,3-methyenedioxy-phenyl)-acylamido)cephalosporanic acid derivatives
NO880088D0 (no) 2,1-benzotiazepin-2,2-dioksyd-5-karboksylsyrederivater.
AU503922B2 (en) 1, 3-benzodioxan-prostanoic acid derivatives
NO882949D0 (no) Dobbelttraadede nukleinsyrederivater.
ATE67482T1 (de) Carbonsaeure-derivate.
AU507074B2 (en) 1, 2-diphneylcyclohex-1-ene carboxylic acid derivatives
AU492122B2 (en) 7-[-amino -w-(2,3-methylene-dioxyphenyl)-acylamido]cephalosporanic acid derivatives
NO794232L (no) Sitronsyrederivater.
ATE102207T1 (de) 1,1-dioxo-cephem-4-carbothiolsaeure-derivate.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee
8370 Indication related to discontinuation of the patent is to be deleted