DE69420394D1 - Pyrrolopyridinderivate als dopaminrezeptor liganden - Google Patents

Pyrrolopyridinderivate als dopaminrezeptor liganden

Info

Publication number: DE69420394D1
Authority: DE; Germany
Prior art keywords: pct; dopamine receptor; image; receptor ligands; pyrrolopyridine derivatives
Prior art date: 1993-03-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69420394T

Other languages

English (en)

Other versions

DE69420394T2 (de

Inventor

Raymond Baker

Neil CURTIS

Janusz Kulagowski

Paul Leeson

Adrian Smith

Mark Ridgill

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon Pharma UK Ltd

Original Assignee

Merck Sharp and Dohme Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-01

Filing date

1994-02-25

Publication date

1999-10-07

1993-03-01 Priority claimed from GB939304110A external-priority patent/GB9304110D0/en

1993-08-05 Priority claimed from GB939316260A external-priority patent/GB9316260D0/en

1994-02-25 Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd

1994-02-25 Priority claimed from PCT/GB1994/000384 external-priority patent/WO1994020459A2/en

1999-10-07 Application granted granted Critical

1999-10-07 Publication of DE69420394D1 publication Critical patent/DE69420394D1/de

2000-04-13 Publication of DE69420394T2 publication Critical patent/DE69420394T2/de

2014-02-26 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000015554 Dopamine receptor Human genes 0.000 title abstract 2
108050004812 Dopamine receptor Proteins 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
150000005255 pyrrolopyridines Chemical class 0.000 title 1
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

DE69420394T 1993-03-01 1994-02-25 Pyrrolopyridinderivate als dopaminrezeptor liganden Expired - Fee Related DE69420394T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939304110A GB9304110D0 (en)	1993-03-01	1993-03-01	Therapeutic agents
GB939316260A GB9316260D0 (en)	1993-08-05	1993-08-05	Therapeutic agents
PCT/GB1994/000384 WO1994020459A2 (en)	1993-03-01	1994-02-25	Pyrrolo-pyridine derivatives as dopamine receptor ligands

Publications (2)

Publication Number	Publication Date
DE69420394D1 true DE69420394D1 (de)	1999-10-07
DE69420394T2 DE69420394T2 (de)	2000-04-13

Family

ID=26302518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69420394T Expired - Fee Related DE69420394T2 (de)	1993-03-01	1994-02-25	Pyrrolopyridinderivate als dopaminrezeptor liganden

Country Status (4)

Country	Link
US (1)	US5700809A (de)
AT (1)	ATE184008T1 (de)
DE (1)	DE69420394T2 (de)
ES (1)	ES2134929T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9605065D0 (en) *	1996-03-11	1996-05-08	Merck Sharp & Dohme	Therapeutic agents
PL1696920T3 (pl) *	2003-12-19	2015-03-31	Plexxikon Inc	Związki i sposoby opracowywania modulatorów Ret
US20070066641A1 (en) *	2003-12-19	2007-03-22	Prabha Ibrahim	Compounds and methods for development of RET modulators
WO2006009755A2 (en) *	2004-06-17	2006-01-26	Plexxikon, Inc.	Azaindoles modulating c-kit activity and uses therefor
US7498342B2 (en) *	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
DE102004060659A1 (de) *	2004-12-15	2006-07-06	Lanxess Deutschland Gmbh	Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung
NZ563444A (en) *	2005-05-17	2011-04-29	Plexxikon Inc	Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors
CA2611105A1 (en) *	2005-06-09	2006-12-21	Mallinckrodt Inc.	Method for separation and purification of naltrexone by preparative chromatography
DK1893612T3 (da)	2005-06-22	2011-11-21	Plexxikon Inc	Pyrrol [2,3-B]pyridin-derivater som proteinkinasehæmmere
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
EP2094701A2 (de)	2006-12-21	2009-09-02	Plexxikon, Inc.	Verbindungen und verfahren zur kinase-modulation und anzeigen dafür
PE20121126A1 (es) *	2006-12-21	2012-08-24	Plexxikon Inc	Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en)	2006-12-21	2008-07-03	Plexxikon, Inc.	Pyrrolo [2,3-b] pyridines as kinase modulators
US20100190777A1 (en)	2007-07-17	2010-07-29	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
MX349923B (es)	2009-04-03	2017-08-21	Hoffmann La Roche	Composiciones del ácido propano-1-sulfónico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil]-amida y el uso de las mismas.
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja)	2009-11-06	2013-03-21	プレキシコンインコーポレーテッド	キナーゼ調節のための化合物、方法およびその適用
PL2672967T3 (pl)	2011-02-07	2019-04-30	Plexxikon Inc	Związki i sposoby modulacji kinaz i wskazania ku temu
AR085279A1 (es)	2011-02-21	2013-09-18	Plexxikon Inc	Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
EP4077306A1 (de) *	2019-12-18	2022-10-26	CHDI Foundation, Inc.	Verbindungen und sonden zur bildgebung von huntingtin-protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2044254B (en) *	1979-01-26	1983-01-26	Wyeth John & Brother Ltd	Piperidine derivatives
US5124335A (en) *	1991-01-30	1992-06-23	Merck & Co., Inc.	Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists
US5622950A (en) *	1993-03-01	1997-04-22	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
US5576319A (en) *	1993-03-01	1996-11-19	Merck, Sharp & Dohme Ltd.	Pyrrolo-pyridine derivatives
CZ224195A3 (en) *	1993-03-01	1996-03-13	Merck Sharp & Dohme	The use of pyrrolopyridine derivatives for preparing pharmaceutical preparations
GB9416189D0 (en) *	1994-08-10	1994-09-28	Merck Sharp & Dohme	Therapeutic agents
AU699196B2 (en) *	1994-08-10	1998-11-26	Merck Sharp & Dohme Limited	Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine
GB9416162D0 (en) *	1994-08-10	1994-09-28	Merck Sharp & Dohme	Therapeutic agents

1994
- 1994-02-25 US US08/513,828 patent/US5700809A/en not_active Expired - Fee Related
- 1994-02-25 ES ES94906978T patent/ES2134929T3/es not_active Expired - Lifetime
- 1994-02-25 DE DE69420394T patent/DE69420394T2/de not_active Expired - Fee Related
- 1994-02-25 AT AT94906978T patent/ATE184008T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE184008T1 (de)	1999-09-15
DE69420394T2 (de)	2000-04-13
US5700809A (en)	1997-12-23
ES2134929T3 (es)	1999-10-16

Legal Events

Date	Code	Title	Description
2000-09-21	8364	No opposition during term of opposition
2004-12-09	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69420394T2 (de)	2000-04-13	Pyrrolopyridinderivate als dopaminrezeptor liganden
MX9401408A (es)	1994-08-31	Nuevos derivados heterociclicos.
ES2121193T3 (es)	1998-11-16	Derivados de bencimidazoles.
KR960701051A (ko)	1996-02-24	이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases)
GR3035621T3 (en)	2001-06-29	New pyrimidone derivatives with antifungal activity
WO1994020459A3 (en)	1994-10-13	Pyrrolo-pyridine derivatives as dopamine receptor ligands
ES2145289T3 (es)	2000-07-01	Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina.
DE69322250D1 (de)	1999-01-07	3-hydroxypyridin-4-on-derivate als chelatbildner
GB9305641D0 (en)	1993-05-05	Therapeutic agents
DE69412073D1 (de)	1998-09-03	Xanthinderivate als adenosin-a1 rezeptor antagonisten
DE69431471T2 (de)	2003-07-10	Amidderivate als 5-HT1A-Liganden
ES2104509A1 (es)	1997-10-01	Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina.
DE69430074T2 (de)	2002-09-05	Analgetische 4-arylisoindolen
DE69403896D1 (de)	1997-07-24	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten
DK0691846T3 (da)	2001-10-08	Imidazoquinoxalinoner til behandling af sygdomme i centralnervesystemet
ES2101644A1 (es)	1997-07-01	Nuevo compuesto derivado del cromeno