DE69330879D1 - Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen - Google Patents

Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen

Info

Publication number
DE69330879D1
DE69330879D1 DE69330879T DE69330879T DE69330879D1 DE 69330879 D1 DE69330879 D1 DE 69330879D1 DE 69330879 T DE69330879 T DE 69330879T DE 69330879 T DE69330879 T DE 69330879T DE 69330879 D1 DE69330879 D1 DE 69330879D1
Authority
DE
Germany
Prior art keywords
pct
hyaluronic acid
replacements
hydrogels
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330879T
Other languages
English (en)
Other versions
DE69330879T2 (de
Inventor
Luigi Nicolais
Luigi Ambrosio
Antonio Netti
Lanfranco Callegaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Application granted granted Critical
Publication of DE69330879D1 publication Critical patent/DE69330879D1/de
Publication of DE69330879T2 publication Critical patent/DE69330879T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
DE69330879T 1992-05-20 1993-05-21 Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen Expired - Lifetime DE69330879T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPD920088A IT1259100B (it) 1992-05-20 1992-05-20 Uso di idrogeli per il bloccaggio di sistemi protesici
PCT/EP1993/001288 WO1993023094A1 (en) 1992-05-20 1993-05-21 Use of hydrogels to fix bone replacements

Publications (2)

Publication Number Publication Date
DE69330879D1 true DE69330879D1 (de) 2001-11-08
DE69330879T2 DE69330879T2 (de) 2002-06-13

Family

ID=11389935

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330879T Expired - Lifetime DE69330879T2 (de) 1992-05-20 1993-05-21 Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen

Country Status (6)

Country Link
US (1) US5645592A (de)
EP (1) EP0642363B1 (de)
AT (1) ATE206316T1 (de)
DE (1) DE69330879T2 (de)
IT (1) IT1259100B (de)
WO (1) WO1993023094A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ITPD940011A1 (it) * 1994-01-28 1995-07-28 Fidia Advanced Biopolymers Srl Rivestimento di oggetti biomedicali mediante microsfere ottenute da polimeri biocompatibili
EP0700671B1 (de) * 1994-09-08 2001-08-08 Stryker Technologies Corporation Bandscheibenkern aus Hydrogel
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
DE59903490D1 (de) * 1998-09-11 2003-01-02 Schmidmaier Gerhard Biologisch aktive implantate
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6358283B1 (en) 1999-06-21 2002-03-19 Hoegfors Christian Implantable device for lengthening and correcting malpositions of skeletal bones
WO2001010302A2 (en) 1999-08-04 2001-02-15 Cbyon, Inc. Biodegradable spinal fiducial implant
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
EP1223990B1 (de) * 1999-10-15 2004-07-28 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
US6579533B1 (en) 1999-11-30 2003-06-17 Bioasborbable Concepts, Ltd. Bioabsorbable drug delivery system for local treatment and prevention of infections
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US7094251B2 (en) 2002-08-27 2006-08-22 Marctec, Llc. Apparatus and method for securing a suture
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US9155544B2 (en) 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
US7820638B2 (en) * 2002-08-09 2010-10-26 Arthrex, Inc. Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density
US7497864B2 (en) 2003-04-30 2009-03-03 Marctec, Llc. Tissue fastener and methods for using same
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
CA2524271C (en) 2003-05-02 2012-09-04 Surmodics, Inc. Controlled release bioactive agent delivery device
CN1878565B (zh) * 2003-09-12 2011-01-12 惠氏公司 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
US20090240276A1 (en) * 2003-11-04 2009-09-24 Parviz Robert Ainpour Gel Plug For Blockage Of The Canaliculus
US20050095269A1 (en) * 2003-11-04 2005-05-05 Ainpour Parviz R. Gel plug for blockage of the canaliculus
US7670377B2 (en) 2003-11-21 2010-03-02 Kyphon Sarl Laterally insertable artifical vertebral disk replacement implant with curved spacer
WO2005077013A2 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Surface directed cellular attachment
WO2005077304A1 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Load bearing biocompatible device
WO2005084748A1 (en) 2004-03-04 2005-09-15 Hadasit Medical Research Services & Development Company Ltd. Safe device for iontophoretic delivery of drugs
US20080039873A1 (en) 2004-03-09 2008-02-14 Marctec, Llc. Method and device for securing body tissue
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
EP1796753B1 (de) * 2004-10-06 2019-03-13 Nobil Bio Ricerche S.r.l. Knochenimplantat beschichtet mit hyaluronsäure
US20060089646A1 (en) 2004-10-26 2006-04-27 Bonutti Peter M Devices and methods for stabilizing tissue and implants
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
WO2006081379A1 (en) * 2005-01-26 2006-08-03 Wyeth Use of sfrps as markers of bmp activity
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US8552100B2 (en) * 2005-02-23 2013-10-08 The Regents Of The University Of California Flexible hydrogel-based functional composite materials
EP1863518A2 (de) * 2005-03-30 2007-12-12 Wyeth VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs
US20060224244A1 (en) * 2005-03-31 2006-10-05 Zimmer Technology, Inc. Hydrogel implant
US20060235542A1 (en) * 2005-04-15 2006-10-19 Zimmer Technology, Inc. Flexible segmented bearing implant
US20060257358A1 (en) * 2005-05-13 2006-11-16 Depuy Products, Inc. Suspension of calcium phosphate particulates for local delivery of therapeutic agents
US20060257492A1 (en) * 2005-05-13 2006-11-16 Depuy Products, Inc. Suspension of calcium phosphate particulates for local delivery of therapeutic agents
AU2006286501B2 (en) * 2005-08-31 2012-12-13 Zimmer Gmbh Implant
US20070088444A1 (en) * 2005-10-13 2007-04-19 Robert A Hodorek Method for repairing a bone defect using a formable implant which hardens in vivo
EP1973498B1 (de) * 2005-11-09 2014-04-23 Zimmer GmbH Implantat
US20070179607A1 (en) * 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
US7967820B2 (en) 2006-02-07 2011-06-28 P Tech, Llc. Methods and devices for trauma welding
US8496657B2 (en) 2006-02-07 2013-07-30 P Tech, Llc. Methods for utilizing vibratory energy to weld, stake and/or remove implants
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US20090048679A1 (en) * 2006-02-09 2009-02-19 Zimmer Gmbh Implant
US8632601B2 (en) * 2006-04-28 2014-01-21 Zimmer, Gmbh Implant
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
CA2618125A1 (en) * 2007-02-08 2008-08-08 Zimmer, Inc. Hydrogel proximal interphalangeal implant
US8617185B2 (en) 2007-02-13 2013-12-31 P Tech, Llc. Fixation device
WO2009018128A2 (en) * 2007-07-31 2009-02-05 Zimmer, Inc. Joint space interpositional prosthetic device with internal bearing surfaces
AU2008318833B2 (en) * 2007-10-29 2014-02-13 Zimmer, Inc. Medical implants and methods for delivering biologically active agents
US20090265016A1 (en) * 2008-04-21 2009-10-22 Lasse Daniel Efskind Material for surgical use in traumatology
US10022164B2 (en) * 2008-06-11 2018-07-17 Eventions, Llc Orthopedic fastener device
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
KR20110040969A (ko) 2008-08-05 2011-04-20 바이오미메디카, 인코포레이티드 폴리우레탄-그라프트된 하이드로겔
WO2010099222A1 (en) 2009-02-24 2010-09-02 P Tech, Llc Methods and devices for utilizing bondable materials
US8668739B2 (en) 2010-08-20 2014-03-11 Zimmer, Inc. Unitary orthopedic implant
CA2808528A1 (en) 2010-08-27 2012-03-01 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
US8676319B2 (en) 2010-10-29 2014-03-18 Medtronic, Inc. Implantable medical device with compressible fixation member
EP3235522A1 (de) * 2011-01-10 2017-10-25 Biomimedica, Inc Orthopädische implantate mit gradienten-polymerlegierungen
CA3048443C (en) 2011-05-26 2021-01-05 Cartiva, Inc. Tapered joint implant and related tools
CA2885996A1 (en) 2011-10-03 2013-04-11 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
US9114024B2 (en) 2011-11-21 2015-08-25 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US9682035B2 (en) 2012-02-23 2017-06-20 The Board Of Trustees Of The Leland Stanford Junior University Injectable hydrogel system to modulate host response at bone implant interface
MX351261B (es) 2012-06-01 2017-10-06 Surmodics Inc Aparato y método para recubrir catéteres con globo.
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
JP6411454B2 (ja) * 2013-03-27 2018-10-24 センター ホスピタリアー ユニヴェルシテール ヴァルド（シー．エイチ．ユー．ヴィ） 再狭窄の治療および／または予防に用いられる医薬製剤
DE102015102210A1 (de) 2015-02-16 2016-08-18 Heraeus Medical Gmbh Antimykotischer polymerisierbarer Knochenzement und ein Verfahren zu seiner Herstellung
CA2981064C (en) 2015-03-31 2024-01-02 Cartiva, Inc. Carpometacarpal (cmc) implants and methods
EP3753531A1 (de) 2015-03-31 2020-12-23 Cartiva, Inc. Hydrogelimplantate mit porösen materialien
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
EP3655474B1 (de) * 2017-07-20 2023-05-24 Sika Technology AG Hydrogele mit verbesserter mechanischer festigkeit
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071242B1 (de) * 1981-07-30 1986-12-03 CERAVER Société anonyme dite: Protheseschaft aus Titan oder Titanlegierung für zementfreie Befestigung in einem langen Knochen
DE3362627D1 (en) * 1982-11-30 1986-04-24 Lrc Products Method of coating rubber or polymer articles
US4527293A (en) * 1983-05-18 1985-07-09 University Of Miami Hydrogel surface of urological prosthesis
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
FR2649404B1 (fr) * 1984-08-23 1994-05-20 Universal High Technologies Procede de revetement hydrophile de matieres plastiques et ses applications medicales
DE3445738A1 (de) * 1984-12-14 1986-06-19 Draenert Klaus Implantat zur knochenverstaerkung und verankerung von knochenschrauben, implantaten oder implantatteilen
DE3533369A1 (de) * 1985-09-19 1987-03-19 Alois Prof Dr Med Bloemer Antibioticahaltiges mittel und seine verwendung als chirurgisches kunststoffmaterial
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
IT1198162B (it) * 1986-11-25 1988-12-21 Luigi Ambrosio Protesi ortopedica per la riduzione di fratture ossee,materiale per la sua fabbricazione e procedimenti per ottenerli
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5329846A (en) * 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system

Also Published As

Publication number Publication date
EP0642363A1 (de) 1995-03-15
IT1259100B (it) 1996-03-11
ITPD920088A1 (it) 1993-11-20
ITPD920088A0 (it) 1992-05-20
WO1993023094A1 (en) 1993-11-25
DE69330879T2 (de) 2002-06-13
US5645592A (en) 1997-07-08
ATE206316T1 (de) 2001-10-15
EP0642363B1 (de) 2001-10-04

Similar Documents

Publication Publication Date Title
DE69330879T2 (de) Verwendung von hydrogelen für die befestigung von knochenersatzmaterialen
ATE188128T1 (de) Die verwendung von monomerem/polymerem material zur herstellung einer härtbaren zusammensetzung für die reparatur von knorpeln
ATE175441T1 (de) Bmp-9 zusammensetzungen
TR199800353T1 (xx) Ameliyat sonras� adhasyon �nleyici biyo-malzemeler.
DE59507122D1 (de) Verfahren zur Herstellung von Überzügen
BR9916146A (pt) Produto de revestimento constituìdo de três componentes, processo para sua produção, bem como utilização do mesmo
DE69635609D1 (de) Nukleinsäure enthaltende zusammensetzung, herstellung und verwendung
DE3880922T2 (de) Faktor viii-analog, verfahren zu dessen herstellung und dieses enthaltende zusammensetzung.
ATE201602T1 (de) Verbessertes verfahren zur fixierung von verkalkungsbestendigen biologischen geweben
ATE267619T1 (de) Kollagenlaminat material und verfahren zu dessen herstellung
ES2125979T3 (es) Nuevos revestimientos bioactivos y su preparacion y empleo.
ES533647A0 (es) Procedimiento para la obtencion de recubrimientos sinteticos a base de polihidroxipoliacrilato y poliisocianatos.
ATE85225T1 (de) Chirurgisches biokompositmaterial und dessen herstellung.
DE69716745D1 (de) Ester von hyaluronsäure, sie enthaltende faden und biomaterialen, ihre verwendung in der chirurgie
BR8300257A (pt) Processo de preparacao de uma nova composicao termoplastica de memoria a partir de policaprolactona e de poliuretano produto obtido de acordo com este processo e sua utilizacao principalmente em ortopedia
DE69125810T2 (de) Verfahren zur enzymatischen herstellung von basischen fibroblasten-wachstumsfaktors
DE59405677D1 (de) Verfahren zur Herstellung von Isocyanaten und kontinuierlicher Aufarbeitung des Rückstandes
BR9812774A (pt) Corpos formados para uso como implantes em medicina humana e método para a produção de tais corpos formados
Doumit et al. The expansile properties of kryptonite relating to cranioplasty
DE60000501D1 (de) Verwendung von melanomhemmendem faktor zur reparatur von knorpelgewebe und knochen
PT96238A (pt) Processo para a preparacao de um material ortopedico para moldacao a base de um pre-polimero de poli-isocianato que possui uma reduzida aderencia e um reduzido deslizamento
DE69535263D1 (de) Angiotensin ii zur verbesserung der befruchtung
DE59606567D1 (de) Neuer Mikroorganismus, dessen Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren
DE69415687T2 (de) Hitzehärtbares beschichtungsmittel
Thomsen et al. Morphological Studies on Titanium Implants Inserted in Rabbit Knee-Joints

Legal Events

Date Code Title Description
8364 No opposition during term of opposition