DE69322708T2 - Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen - Google Patents
Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinenInfo
- Publication number
- DE69322708T2 DE69322708T2 DE69322708T DE69322708T DE69322708T2 DE 69322708 T2 DE69322708 T2 DE 69322708T2 DE 69322708 T DE69322708 T DE 69322708T DE 69322708 T DE69322708 T DE 69322708T DE 69322708 T2 DE69322708 T2 DE 69322708T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- deoxytetracyclines
- demethyl
- amido
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/928,588 US5284963A (en) | 1992-08-13 | 1992-08-13 | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69322708D1 DE69322708D1 (de) | 1999-02-04 |
DE69322708T2 true DE69322708T2 (de) | 1999-04-29 |
Family
ID=25456483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69322708T Expired - Lifetime DE69322708T2 (de) | 1992-08-13 | 1993-05-12 | Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen |
Country Status (27)
Country | Link |
---|---|
US (1) | US5284963A (de) |
EP (1) | EP0582790B1 (de) |
JP (1) | JP3590643B2 (de) |
KR (1) | KR100250603B1 (de) |
CN (1) | CN1037680C (de) |
AT (1) | ATE174903T1 (de) |
AU (1) | AU674689B2 (de) |
CA (1) | CA2103837C (de) |
CZ (1) | CZ286261B6 (de) |
DE (1) | DE69322708T2 (de) |
DK (1) | DK0582790T3 (de) |
ES (1) | ES2125927T3 (de) |
FI (1) | FI115722B (de) |
GR (1) | GR3029764T3 (de) |
HU (1) | HU222886B1 (de) |
IL (3) | IL119551A (de) |
LV (1) | LV12273B (de) |
MX (1) | MX9304649A (de) |
NO (1) | NO303574B1 (de) |
NZ (1) | NZ248358A (de) |
PH (1) | PH30150A (de) |
PL (2) | PL173606B1 (de) |
RU (1) | RU2111958C1 (de) |
SG (1) | SG68556A1 (de) |
SK (1) | SK281698B6 (de) |
TW (1) | TW221285B (de) |
ZA (1) | ZA935891B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5248797A (en) * | 1992-08-13 | 1993-09-28 | American Cyanamid Company | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6946118B1 (en) * | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
HUP0202798A3 (en) * | 1999-09-14 | 2003-11-28 | Trustees Of Tufts College Medf | Methods of preparing substituted tetracyclines with transition metal-based reactions |
AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
KR100997596B1 (ko) * | 2000-07-07 | 2010-11-30 | 파라테크 파마슈티컬스, 인크. | 7-치환 테트라사이클린 화합물 |
US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
MXPA03000055A (es) * | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
EP2298732A1 (de) * | 2001-03-13 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | 7, 9-substituierte Tetracyclin-Verbindungen |
EP1241160A1 (de) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
EP2332547A1 (de) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclinverbindungen zur Behandlung von entzündlicher Darmerkrankung |
WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
EP2995610A1 (de) * | 2002-01-08 | 2016-03-16 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino-tetracyclin-verbindungen |
JP2005526754A (ja) * | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
WO2003079984A2 (en) | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
US20050143352A1 (en) * | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
EP2295419A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclinverbindungen |
US7534766B2 (en) | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
JP2008530023A (ja) | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の11a,12−誘導体 |
US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
PE20070072A1 (es) * | 2005-06-16 | 2007-02-25 | Wyeth Corp | Proceso de manufactura para tigeciclina como polvo reconstituible |
CN101340917A (zh) * | 2005-12-22 | 2009-01-07 | 惠氏公司 | 用替加环素治疗胃肠道感染的方法 |
CN101489987A (zh) * | 2006-04-17 | 2009-07-22 | 特瓦制药工业有限公司 | 四环素衍生物的分离 |
TW200812943A (en) * | 2006-04-24 | 2008-03-16 | Teva Pharma | Processes for preparation of tigecycline crystalline forms I and II |
US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
WO2007133797A2 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
US20070286818A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via an aerosol drug |
US20070286817A1 (en) * | 2006-06-07 | 2007-12-13 | Wyeth | Treating cystic fibrosis with antibiotics via a swirler delivery |
AR061485A1 (es) * | 2006-06-15 | 2008-08-27 | Serenex Inc | Composiciones estabilizadas de tetraciclina |
WO2008066935A2 (en) * | 2006-11-29 | 2008-06-05 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
BRPI0706517A2 (pt) * | 2006-11-30 | 2011-03-29 | Teva Pharma | processos para preparação de f 9-haloacetamidominociclinas |
WO2008106234A1 (en) * | 2007-03-01 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
AT13157U1 (de) * | 2007-04-24 | 2013-07-15 | Teva Pharma | Tigecyclin, kristalline Formen und Herstellungsverfahren dafür |
US20090076153A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched tigecycline |
AR069494A1 (es) | 2007-11-29 | 2010-01-27 | Actelion Pharmaceuticals Ltd | Derivados de acidos fosfonicos |
CN102177134B (zh) | 2008-08-08 | 2014-04-16 | 麻州四期制药公司 | C7-氟取代的四环素化合物 |
DK2427425T3 (en) | 2009-05-08 | 2017-06-12 | Tetraphase Pharmaceuticals Inc | tetracycline |
PT2470500T (pt) | 2009-08-28 | 2018-01-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina |
AU2013308504B2 (en) | 2012-08-31 | 2016-11-10 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
US10961190B2 (en) | 2016-10-19 | 2021-03-30 | Tetraphase Pharmaceuticals, Inc. | Crystalline forms of eravacycline |
EP3976050A1 (de) | 2019-05-24 | 2022-04-06 | Stichting Radboud universitair medisch centrum | Verbesserte verabreichung von glycylcyclinen durch inhalation |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
US3007965A (en) * | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
FR1430859A (de) * | 1960-05-23 | 1966-05-25 | ||
US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
US3360557A (en) * | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
DE69232302D1 (de) * | 1991-10-04 | 2002-01-31 | American Cyanamid Co | 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline |
US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
-
1992
- 1992-08-13 US US07/928,588 patent/US5284963A/en not_active Expired - Lifetime
- 1992-11-03 TW TW081108731A patent/TW221285B/zh active
-
1993
- 1993-05-12 DE DE69322708T patent/DE69322708T2/de not_active Expired - Lifetime
- 1993-05-12 DK DK93107719T patent/DK0582790T3/da active
- 1993-05-12 ES ES93107719T patent/ES2125927T3/es not_active Expired - Lifetime
- 1993-05-12 EP EP93107719A patent/EP0582790B1/de not_active Expired - Lifetime
- 1993-05-12 AT AT93107719T patent/ATE174903T1/de not_active IP Right Cessation
- 1993-05-12 SG SG1996003389A patent/SG68556A1/en unknown
- 1993-06-17 CN CN93107463A patent/CN1037680C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304649A patent/MX9304649A/es unknown
- 1993-08-04 CZ CZ19931577A patent/CZ286261B6/cs not_active IP Right Cessation
- 1993-08-06 SK SK849-93A patent/SK281698B6/sk not_active IP Right Cessation
- 1993-08-09 NZ NZ248358A patent/NZ248358A/en not_active IP Right Cessation
- 1993-08-10 JP JP21816793A patent/JP3590643B2/ja not_active Expired - Fee Related
- 1993-08-10 PH PH46662A patent/PH30150A/en unknown
- 1993-08-11 CA CA002103837A patent/CA2103837C/en not_active Expired - Fee Related
- 1993-08-12 FI FI933566A patent/FI115722B/fi active IP Right Grant
- 1993-08-12 HU HU9302331A patent/HU222886B1/hu active IP Right Grant
- 1993-08-12 KR KR1019930015643A patent/KR100250603B1/ko not_active IP Right Cessation
- 1993-08-12 PL PL93300064A patent/PL173606B1/pl not_active IP Right Cessation
- 1993-08-12 ZA ZA935891A patent/ZA935891B/xx unknown
- 1993-08-12 PL PL93316522A patent/PL173923B1/pl not_active IP Right Cessation
- 1993-08-12 IL IL11955193A patent/IL119551A/xx not_active IP Right Cessation
- 1993-08-12 RU RU93043144A patent/RU2111958C1/ru not_active IP Right Cessation
- 1993-08-12 AU AU44603/93A patent/AU674689B2/en not_active Ceased
- 1993-08-12 NO NO932870A patent/NO303574B1/no not_active IP Right Cessation
- 1993-08-12 IL IL10667493A patent/IL106674A/en not_active IP Right Cessation
-
1996
- 1996-11-03 IL IL11955196A patent/IL119551A0/xx unknown
-
1999
- 1999-02-08 LV LVP-99-19A patent/LV12273B/en unknown
- 1999-03-22 GR GR990400850T patent/GR3029764T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69322708T2 (de) | Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen | |
ATE58896T1 (de) | Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2azetidinonen. | |
ATE153332T1 (de) | Verfahren zur herstellung von oxetanonen | |
DE69530242D1 (de) | Verfahren zur Herstellung von Glutaminsäure durch Fermentation | |
DE69210347T2 (de) | Verfahren zur Herstellung von Zwischenprodukten zur Verwendung in der Herstellung von Alkoxyiminoacetamide | |
ATE194142T1 (de) | Verfahren zur herstellung von nukleotiden | |
DE69231815T2 (de) | Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren | |
DE69531308D1 (de) | Verfahren zur Herstellung von gereinigten papillomavirus Proteinen | |
DE3576952D1 (de) | Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten. | |
ATE407127T1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
DE69635057D1 (de) | Verfahren zur herstellung von campothecinderivate | |
DE60015563D1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
ATE229006T1 (de) | Verfahren zur herstellung von schwefelhaltigen imidazolderivaten und erhaltene zwischenprodukte | |
ATE234288T1 (de) | Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür | |
DE69404932D1 (de) | Zwischenprodukte zur Herstellung von Vitamin A und von Carotenoiden und Verfahren zu deren Herstellung | |
ATE157967T1 (de) | Zwischenprodukte zur herstellung von vitamin a und von carotenoiden und verfahren zu deren herstellung | |
ATE160147T1 (de) | Verfahren zur herstellung von enantiomer reinem imidazo (4,5,1-jk) (1,4)-benzodiazepin-2(1h)- thionen | |
ATE240937T1 (de) | Gamma-oxohomophenylalanin derivate und ein verfahren zur herstellung von homophenylalanin derivaten durch reduktion derselben | |
ATE404540T1 (de) | Verfahren zur herstellung von 1-substituierten 5- chlor-4methylpyrazolen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US |