DE69307730T2 - Verfahren zur herstellung von taxanderivaten, die so erlangten neuen derivate und diese enthaltende zusammensetzungen - Google Patents

Verfahren zur herstellung von taxanderivaten, die so erlangten neuen derivate und diese enthaltende zusammensetzungen

Info

Publication number: DE69307730T2
Authority: DE; Germany
Prior art keywords: derivatives; pct; formula; date; production
Prior art date: 1992-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69307730T

Other languages

English (en)

Other versions

DE69307730D1 (de

Inventor

Herve Bouchard

Jean-Dominique Bourzat

Alain Commercon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Rhone Poulenc Rorer SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-23

Filing date

1993-11-22

Publication date

1997-06-05

1993-11-22 Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA

1997-03-06 Application granted granted Critical

1997-03-06 Publication of DE69307730D1 publication Critical patent/DE69307730D1/de

1997-06-05 Publication of DE69307730T2 publication Critical patent/DE69307730T2/de

2013-11-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title 1
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000000719 anti-leukaemic effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1
-1 tiazole Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

DE69307730T 1992-11-23 1993-11-22 Verfahren zur herstellung von taxanderivaten, die so erlangten neuen derivate und diese enthaltende zusammensetzungen Expired - Fee Related DE69307730T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9214023A FR2698363B1 (fr)	1992-11-23	1992-11-23	Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
PCT/FR1993/001145 WO1994012484A1 (fr)	1992-11-23	1993-11-22	Nouveau procede de preparation de derives du taxane, nouveaux derives ainsi obtenus et les compositions qui les contiennent

Publications (2)

Publication Number	Publication Date
DE69307730D1 DE69307730D1 (de)	1997-03-06
DE69307730T2 true DE69307730T2 (de)	1997-06-05

Family

ID=9435782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69307730T Expired - Fee Related DE69307730T2 (de)	1992-11-23	1993-11-22	Verfahren zur herstellung von taxanderivaten, die so erlangten neuen derivate und diese enthaltende zusammensetzungen

Country Status (23)

Country	Link
US (1)	US5606083A (de)
EP (1)	EP0669916B1 (de)
JP (1)	JPH08503486A (de)
KR (1)	KR950704286A (de)
AT (1)	ATE148111T1 (de)
AU (1)	AU680455B2 (de)
CA (1)	CA2149758A1 (de)
CZ (1)	CZ131795A3 (de)
DE (1)	DE69307730T2 (de)
DK (1)	DK0669916T3 (de)
ES (1)	ES2096440T3 (de)
FI (1)	FI952482A (de)
FR (1)	FR2698363B1 (de)
GR (1)	GR3022359T3 (de)
HU (1)	HUT74069A (de)
NO (1)	NO952017D0 (de)
NZ (1)	NZ258144A (de)
PL (1)	PL309037A1 (de)
RU (1)	RU95113421A (de)
SK (1)	SK68195A3 (de)
TW (1)	TW254938B (de)
WO (1)	WO1994012484A1 (de)
ZA (1)	ZA938728B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5698582A (en) *	1991-07-08	1997-12-16	Rhone-Poulenc Rorer S.A.	Compositions containing taxane derivatives
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5677470A (en)	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) *	1995-03-22	1996-09-23	John K. Thottathil	Novel methods for the preparation of taxanes using oaxzolidine intermediates
US20030157187A1 (en) *	1996-12-02	2003-08-21	Angiotech Pharmaceuticals, Inc.	Compositions and methods for treating or preventing inflammatory diseases
US6515016B2 (en)	1996-12-02	2003-02-04	Angiotech Pharmaceuticals, Inc.	Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en)	1996-12-02	2002-12-17	Angiotech Pharmaceuticals, Inc.	Method for treating multiple sclerosis
US7288665B1 (en)	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
ATE234800T1 (de)	1997-08-21	2003-04-15	Univ Florida State	Verfahren zur synthese von taxanen
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20040132991A1 (en) *	2002-10-09	2004-07-08	Phytogen Life Sciences Inc.	Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2008033466A2 (en) *	2006-09-14	2008-03-20	Combinatorx (Singapore) Pre. Ltd.	Compositions and methods for treatment of viral diseases
FR2986526A1 (fr)	2012-02-03	2013-08-09	Sanofi Sa	Procede de preparation de derives du taxol et certains composes intermediaires
CN104650109B (zh) *	2013-11-22	2019-01-01	江苏天士力帝益药业有限公司	紫杉烷类化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides

1992
- 1992-11-23 FR FR9214023A patent/FR2698363B1/fr not_active Expired - Fee Related
1993
- 1993-11-22 EP EP94900862A patent/EP0669916B1/de not_active Expired - Lifetime
- 1993-11-22 CA CA002149758A patent/CA2149758A1/fr not_active Abandoned
- 1993-11-22 HU HU9501500A patent/HUT74069A/hu unknown
- 1993-11-22 WO PCT/FR1993/001145 patent/WO1994012484A1/fr not_active Application Discontinuation
- 1993-11-22 DE DE69307730T patent/DE69307730T2/de not_active Expired - Fee Related
- 1993-11-22 JP JP6512841A patent/JPH08503486A/ja active Pending
- 1993-11-22 PL PL93309037A patent/PL309037A1/xx unknown
- 1993-11-22 AU AU55659/94A patent/AU680455B2/en not_active Ceased
- 1993-11-22 NZ NZ258144A patent/NZ258144A/en unknown
- 1993-11-22 CZ CZ951317A patent/CZ131795A3/cs unknown
- 1993-11-22 RU RU95113421/04A patent/RU95113421A/ru unknown
- 1993-11-22 AT AT94900862T patent/ATE148111T1/de not_active IP Right Cessation
- 1993-11-22 ES ES94900862T patent/ES2096440T3/es not_active Expired - Lifetime
- 1993-11-22 ZA ZA938728A patent/ZA938728B/xx unknown
- 1993-11-22 DK DK94900862.7T patent/DK0669916T3/da active
- 1993-11-22 SK SK681-95A patent/SK68195A3/sk unknown
- 1993-11-22 US US08/424,512 patent/US5606083A/en not_active Expired - Fee Related
- 1993-11-22 TW TW082109812A patent/TW254938B/zh active
1995
- 1995-05-22 KR KR1019950702091A patent/KR950704286A/ko not_active Application Discontinuation
- 1995-05-22 FI FI952482A patent/FI952482A/fi not_active Application Discontinuation
- 1995-05-22 NO NO952017A patent/NO952017D0/no unknown
1997
- 1997-01-23 GR GR960403091T patent/GR3022359T3/el unknown

Also Published As

Publication number	Publication date
NO952017L (no)	1995-05-22
EP0669916B1 (de)	1997-01-22
AU680455B2 (en)	1997-07-31
RU95113421A (ru)	1997-03-20
DK0669916T3 (da)	1997-02-10
FR2698363B1 (fr)	1994-12-30
PL309037A1 (en)	1995-09-18
ZA938728B (en)	1994-06-28
CA2149758A1 (fr)	1994-06-09
SK68195A3 (en)	1995-10-11
HU9501500D0 (en)	1995-07-28
HUT74069A (en)	1996-10-28
TW254938B (de)	1995-08-21
WO1994012484A1 (fr)	1994-06-09
EP0669916A1 (de)	1995-09-06
CZ131795A3 (en)	1995-10-18
US5606083A (en)	1997-02-25
GR3022359T3 (en)	1997-04-30
FI952482A (fi)	1995-05-24
ES2096440T3 (es)	1997-03-01
NZ258144A (en)	1996-10-28
JPH08503486A (ja)	1996-04-16
FR2698363A1 (fr)	1994-05-27
FI952482A0 (fi)	1995-05-22
AU5565994A (en)	1994-06-22
ATE148111T1 (de)	1997-02-15
NO952017D0 (no)	1995-05-22
KR950704286A (ko)	1995-11-17
DE69307730D1 (de)	1997-03-06

Legal Events

Date	Code	Title	Description
1998-02-19	8364	No opposition during term of opposition
2000-02-10	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69307730D1 (de)	1997-03-06	Verfahren zur herstellung von taxanderivaten, die so erlangten neuen derivate und diese enthaltende zusammensetzungen
DE69308154T2 (de)	1997-09-25	Verfahren zur herstellung von taxan-derivaten
DK0687259T3 (da)	1997-05-26	Fremgangsmåde til fremstilling af taxoider
HU9501585D0 (en)	1995-08-28	Azoxycyanobenzene-derivatives, process for their preparation, fungicidal compositions containing them
DE69300766T2 (de)	1996-04-18	Verfahren zur herstellung von taxanderivaten.
DE69504341T2 (de)	1999-03-11	Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
NO951840L (no)	1995-05-10	Fremgangsmåte for fremstilling av 1,3-oksazolidin-5-karboksylsyre
AR004406A1 (es)	1998-11-04	Nuevos taxoides, su preparacion y las composiciones farmaceuticas que los contienen.