DE69133575D1 - Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen - Google Patents

Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen

Info

Publication number
DE69133575D1
DE69133575D1 DE69133575T DE69133575T DE69133575D1 DE 69133575 D1 DE69133575 D1 DE 69133575D1 DE 69133575 T DE69133575 T DE 69133575T DE 69133575 T DE69133575 T DE 69133575T DE 69133575 D1 DE69133575 D1 DE 69133575D1
Authority
DE
Germany
Prior art keywords
nitric oxide
newborn
treatment
pulmonary hypertension
persistent pulmonary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133575T
Other languages
English (en)
Other versions
DE69133575T2 (de
Inventor
Warren M Zapol
Claes Frostell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27089304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133575(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE69133575D1 publication Critical patent/DE69133575D1/de
Application granted granted Critical
Publication of DE69133575T2 publication Critical patent/DE69133575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
DE69133575T 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen Expired - Lifetime DE69133575T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62286590A 1990-12-05 1990-12-05
US76723491A 1991-09-27 1991-09-27
US767234 1991-09-27
US622865 1996-03-29

Publications (2)

Publication Number Publication Date
DE69133575D1 true DE69133575D1 (de) 2007-09-06
DE69133575T2 DE69133575T2 (de) 2008-04-17

Family

ID=27089304

Family Applications (9)

Application Number Title Priority Date Filing Date
DE69133584A Expired - Lifetime DE69133584D1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE122007000103C Pending DE122007000103I1 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen
DE69133575T Expired - Lifetime DE69133575T2 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen
DE200812000012 Active DE122008000012I2 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma.
DE69133584T Expired - Lifetime DE69133584T4 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE69127756T Expired - Lifetime DE69127756T2 (de) 1990-12-05 1991-12-05 Verwendung von no zur behandlung oder prävention der bronchokonstriktion
DE2002199002 Pending DE10299002I1 (de) 1990-12-05 1991-12-05 Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion
DE0786264T Pending DE786264T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE0560928T Pending DE560928T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum behandeln einer lungengefässverengung und von asthma.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69133584A Expired - Lifetime DE69133584D1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE122007000103C Pending DE122007000103I1 (de) 1990-12-05 1991-12-05 Verwendung von NO zur Behandlung der persistenten pulmonalen Hypertonie des Neugeborenen

Family Applications After (6)

Application Number Title Priority Date Filing Date
DE200812000012 Active DE122008000012I2 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefassverengung und von Asthma.
DE69133584T Expired - Lifetime DE69133584T4 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE69127756T Expired - Lifetime DE69127756T2 (de) 1990-12-05 1991-12-05 Verwendung von no zur behandlung oder prävention der bronchokonstriktion
DE2002199002 Pending DE10299002I1 (de) 1990-12-05 1991-12-05 Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion
DE0786264T Pending DE786264T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum Behandeln einen Lungengefässverengung und von Asthma
DE0560928T Pending DE560928T1 (de) 1990-12-05 1991-12-05 Vorrichtung zum behandeln einer lungengefässverengung und von asthma.

Country Status (17)

Country Link
US (2) US5873359A (de)
EP (4) EP1875917A3 (de)
JP (3) JP2701978B2 (de)
AT (3) ATE158509T1 (de)
AU (1) AU657726B2 (de)
CA (1) CA2097823C (de)
DE (9) DE69133584D1 (de)
DK (3) DK0786264T3 (de)
EE (1) EE03119B1 (de)
ES (3) ES2082732T3 (de)
GR (3) GR960300032T1 (de)
HK (3) HK1020686A1 (de)
LU (3) LU90886I2 (de)
LV (1) LV12201B (de)
NL (3) NL300081I2 (de)
SG (1) SG47527A1 (de)
WO (1) WO1992010228A1 (de)

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US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation

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CA2097823C (en) 1999-06-29
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GR960300032T1 (en) 1996-06-30
HK1010101A1 (en) 1999-06-11
ATE376850T1 (de) 2007-11-15
AU9149891A (en) 1992-07-08
DE69133584T4 (de) 2009-11-19
DK0560928T3 (da) 1997-12-01
EP1875917A2 (de) 2008-01-09
US5873359A (en) 1999-02-23
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EP1516639A1 (de) 2005-03-23
ATE367842T2 (de) 2007-08-15
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HK1020686A1 (en) 2003-06-19
LU91404I2 (fr) 2008-02-21
EP0560928B1 (de) 1997-09-24
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DE122007000103I1 (de) 2008-04-03
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