DE69133574D1 - Verfahren zur Unterscheidung von Sequenz Varianten - Google Patents

Verfahren zur Unterscheidung von Sequenz Varianten

Info

Publication number
DE69133574D1
DE69133574D1 DE69133574T DE69133574T DE69133574D1 DE 69133574 D1 DE69133574 D1 DE 69133574D1 DE 69133574 T DE69133574 T DE 69133574T DE 69133574 T DE69133574 T DE 69133574T DE 69133574 D1 DE69133574 D1 DE 69133574D1
Authority
DE
Germany
Prior art keywords
sequence variants
nucleic acid
distinguishing sequence
distinguishing
identify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133574T
Other languages
English (en)
Other versions
DE69133574T2 (de
Inventor
David Gelfand
Pamela Holland
Randall Saiki
Robert Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24251781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133574(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69133574D1 publication Critical patent/DE69133574D1/de
Publication of DE69133574T2 publication Critical patent/DE69133574T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
DE69133574T 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten Expired - Lifetime DE69133574T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US563758 1990-08-06
US07/563,758 US5210015A (en) 1990-08-06 1990-08-06 Homogeneous assay system using the nuclease activity of a nucleic acid polymerase

Publications (2)

Publication Number Publication Date
DE69133574D1 true DE69133574D1 (de) 2007-08-09
DE69133574T2 DE69133574T2 (de) 2008-03-06

Family

ID=24251781

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69133574T Expired - Lifetime DE69133574T2 (de) 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten
DE69133329T Expired - Lifetime DE69133329T3 (de) 1990-08-06 1991-08-06 Markierte Oligonukleotide
DE69132521T Expired - Lifetime DE69132521T3 (de) 1990-08-06 1991-08-06 Homogenes testsystem

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69133329T Expired - Lifetime DE69133329T3 (de) 1990-08-06 1991-08-06 Markierte Oligonukleotide
DE69132521T Expired - Lifetime DE69132521T3 (de) 1990-08-06 1991-08-06 Homogenes testsystem

Country Status (10)

Country Link
US (6) US5210015A (de)
EP (3) EP0543942B2 (de)
JP (1) JP2825976B2 (de)
AT (3) ATE365812T1 (de)
AU (1) AU666837B2 (de)
CA (1) CA2088683C (de)
DE (3) DE69133574T2 (de)
DK (3) DK0919565T4 (de)
ES (3) ES2209033T5 (de)
WO (1) WO1992002638A1 (de)

Families Citing this family (1331)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US5795762A (en) * 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5466591A (en) * 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US6872816B1 (en) * 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
DE69231853T2 (de) * 1991-11-07 2001-09-13 Nanotronics Inc Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
FI115214B (fi) * 1992-01-22 2005-03-31 Hoechst Ag Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
US6033909A (en) * 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
EP0654093B1 (de) * 1992-08-03 2001-01-03 Abbott Laboratories Nachweis und amplifikation bestimmter nukleinsäuren mittels exonukleolytischer aktivität
DE4239531A1 (de) * 1992-11-25 1994-05-26 Gabor Dr Igloi Reagenz zur Kupplung verschiedener Substanzen an Nukleinsäuren sowie Verfahren zu dessen Herstellung
US5888780A (en) * 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US5422253A (en) * 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US7785852B2 (en) * 1992-12-07 2010-08-31 Third Wave Technologies, Inc. Cleavage of nucleic acids
US6372424B1 (en) * 1995-08-30 2002-04-16 Third Wave Technologies, Inc Rapid detection and identification of pathogens
US5614402A (en) * 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US6673616B1 (en) 1992-12-07 2004-01-06 Third Wave Technologies, Inc. Methods and compositions for characterizing nucleic acids
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US20060084092A1 (en) * 1993-01-05 2006-04-20 Gelfand David H Homogeneous assay system
JP3099853B2 (ja) * 1993-02-19 2000-10-16 株式会社日立製作所 核酸の測定試薬及び測定方法
WO1994023069A1 (en) * 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
DE4344742A1 (de) * 1993-06-09 1994-12-15 Boehringer Mannheim Gmbh Verfahren zur Immobilisierung von Nukleinsäuren
JPH0723800A (ja) * 1993-07-08 1995-01-27 Tanabe Seiyaku Co Ltd 核酸の検出方法
US6576419B1 (en) * 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
ATE208658T1 (de) * 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
EP0724717B1 (de) * 1993-10-21 1998-08-19 Abbott Laboratories Vorrichtung und verfahren zur überführung einer probe eines fluids
US5645801A (en) * 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US6821727B1 (en) 1993-11-15 2004-11-23 Applera Corporation Hybridization assay using self-quenching fluorescence probe
WO1995014106A2 (en) * 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
DE69432919T2 (de) * 1993-12-28 2004-05-27 Tanabe Seiyaku Co., Ltd. Verfahren für den Nachweis spezifischer Polynukleotiden
US5869255A (en) 1994-02-01 1999-02-09 The Regents Of The University Of California Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
CA2159830C (en) * 1994-04-29 2001-07-03 Timothy M Woudenberg System for real time detection of nucleic acid amplification products
DE69427876T2 (de) * 1994-05-23 2002-04-11 Biotronics Corp Methode zur detektion einer gezielten nukleinsäure
NZ287118A (en) * 1994-05-28 1999-01-28 Tepnel Medical Ltd Method of detecting and amplifying oligonucleotides
US5773213A (en) * 1994-06-06 1998-06-30 Brigham & Women's Hospital Method for conducting sequential nucleic acid hybridization steps
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5580730A (en) * 1994-08-19 1996-12-03 Olympus America, Inc. Enzyme digestion method for the detection of amplified DNA
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
CA2203627C (en) * 1994-11-09 2000-06-06 James E. Dahlberg Rapid detection and identification of nucleic acid variants and pathogens
US5512441A (en) * 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5571673A (en) * 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5786139A (en) * 1994-12-09 1998-07-28 Panvera Corporation Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
EP0842294B1 (de) * 1994-12-23 2002-10-23 Dade Behring Inc. Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
WO1996021144A1 (en) * 1994-12-30 1996-07-11 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US5952238A (en) * 1995-02-02 1999-09-14 Chugai Seiyaku Kabushiki Kaisha Method of assaying specimen substance by controlling dose of chemiluminescence
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
WO1996034983A1 (en) * 1995-05-05 1996-11-07 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
US5994063A (en) * 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US6027879A (en) * 1995-08-09 2000-02-22 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
EP0790861A1 (de) * 1995-09-12 1997-08-27 Becton, Dickinson and Company Verfahren und vorrichtung zur dns-amplifikation und test
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
DE19548680A1 (de) * 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Verfahren zum quantitativen Nachweis von spezifischen Nukleinsäuresequenzen
CA2243989A1 (en) * 1996-01-23 1997-07-31 Rapigene, Inc. Methods and compositions for detecting binding of ligand pair using non-fluorescent label
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US7432048B2 (en) * 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US6913881B1 (en) 1996-01-24 2005-07-05 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
EP1634890B1 (de) * 1996-01-24 2008-11-19 Third Wave Technologies, Inc. Invasive Spaltung von Nukleinsäuren
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US7527928B2 (en) * 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US5763184A (en) 1996-01-30 1998-06-09 Roche Molecular Systems, Inc. Nucleotide sequence variation in the ABO glycosyltransferase gene
US5716784A (en) * 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
US5874216A (en) 1996-02-23 1999-02-23 Ensys Environmental Products, Inc. Indirect label assay device for detecting small molecules and method of use thereof
ATE309387T1 (de) * 1996-03-01 2005-11-15 Du Pont Methode zur vervielfältigung und zum nachweis eines gewünschten nukleinsäurefragments
CA2199213C (en) 1996-03-11 2007-04-17 John Wesley Backus Amplifying and detecting target nucleic acids using a post amplification incubation step
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
AU2735797A (en) * 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
EP0892808B1 (de) * 1996-04-12 2008-05-14 PHRI Properties, Inc. Sonden, kits und assays
US5955268A (en) * 1996-04-26 1999-09-21 Abbott Laboratories Method and reagent for detecting multiple nucleic acid sequences in a test sample
US5887385A (en) 1996-05-28 1999-03-30 Rite-Hite Holding Corporation Release mechanism for industrial doors
ATE428801T1 (de) * 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
DE69738605T2 (de) * 1996-06-04 2009-04-30 University Of Utah Research Foundation, Salt Lake City Behälter zum Durchführen und Beobachten biologischer Prozesse
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US5853990A (en) 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
US20050202499A1 (en) * 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
CA2273204C (en) 1996-11-29 2008-10-14 Third Wave Technologies, Inc. Fen-1 endonucleases, mixtures and cleavage methods
US5840879A (en) * 1996-12-06 1998-11-24 Wang; Edge R. Reagents and solid supports for improved synthesis and labeling of polynucleotides
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
JP3948503B2 (ja) * 1997-08-01 2007-07-25 誠 鶴岡 蛍光偏光法による核酸の測定方法およびＶｅｒｏ毒素生産菌の検出方法
JP3174751B2 (ja) * 1997-09-30 2001-06-11 財団法人 東京都医学研究機構 リアルタイム検出ｐｃｒ法によるｈｃｖ遺伝子の測定方法並びにそれに用いられるプライマー及びプローブ
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
AU1366299A (en) * 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6077669A (en) * 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
CA2308762A1 (en) 1997-11-04 1999-05-14 Roche Diagnostics Gmbh Specific and sensitive nucleic acid detection method
US6294326B1 (en) 1997-11-07 2001-09-25 Abbott Laboratories Analyte detection process using dual labeled probes
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
DE19752898A1 (de) * 1997-11-28 1999-08-05 Centeon Pharma Gmbh Verfahren zum Nachweis hoher Vierenkonzentrationen im Blutplasma und/oder Blutserum mittels der Polymerasekettenreaktion
ES2290979T3 (es) * 1997-12-15 2008-02-16 Csl Behring Gmbh Cebador marcado para uso en la deteccion de acidos nucleicos diana.
DE19755642B4 (de) * 1997-12-15 2005-03-10 Zlb Behring Gmbh Markierter Primer für die Polymerasekettenreaktion
ATE469982T1 (de) * 1998-02-04 2010-06-15 Life Technologies Corp Bestimmung des genotyps eines amplifikationsproduktes an mehreren allelen stellen
EP1055001A1 (de) 1998-02-05 2000-11-29 Bavarian Nordic Research Institute A/S Quantifizierung durch inhibierung der amplifikation
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US6127121A (en) 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
GB9808145D0 (en) * 1998-04-17 1998-06-17 Zeneca Ltd Assay
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
DE19822108A1 (de) * 1998-05-12 2000-02-03 Schering Ag Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika
US6468743B1 (en) 1998-05-18 2002-10-22 Conagra Grocery Products Company PCR techniques for detecting microbial contaminants in foodstuffs
DE19824535A1 (de) 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
EP1086209B1 (de) 1998-06-17 2007-08-22 Amersham Biosciences Corp. Fy7 polymerase
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US20040203078A1 (en) * 1998-07-22 2004-10-14 National Institute Of Advanced Industrial Science And Technology Labeled complex, process for producing same and process for utilizing same
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
IL126776A (en) * 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
US6492111B1 (en) * 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US6441152B1 (en) * 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
EP1013775A1 (de) * 1998-12-21 2000-06-28 LUTZ, Hans Quantitative Polymerase-Kettenreaktion mittels fluorogenen Echtzeiterfassungssystem
US6432642B1 (en) * 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
DE19906169A1 (de) * 1999-02-08 2000-08-10 Bioinside Ges Fuer Biodiagnost Testkit und Verfahren zum quantitativen Nachweis von gentechnisch veränderter DNS in Lebensmitteln mittels fluoreszenzgekoppelter PCR
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6573047B1 (en) 1999-04-13 2003-06-03 Dna Sciences, Inc. Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation
GB9908437D0 (en) * 1999-04-13 1999-06-09 Minton Treharne & Davies Limit Methods of marking materials
DE29906582U1 (de) * 1999-04-14 2000-09-21 Langenbach Guido Crashschutzvorrichtung
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
DE19923168A1 (de) 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
AU5285800A (en) 1999-05-24 2000-12-12 Invitrogen Corporation Method for deblocking of labeled oligonucleotides
US7097973B1 (en) 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
AU5882000A (en) 1999-06-22 2001-01-09 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
WO2000078942A1 (en) * 1999-06-23 2000-12-28 Genesource, Inc. Non-destructive cell-based assay
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
US6692834B1 (en) * 1999-06-28 2004-02-17 Medtronic, Inc. Method for coating implantable devices
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6339147B1 (en) 1999-07-29 2002-01-15 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
US7169553B1 (en) * 1999-08-30 2007-01-30 Roche Diagnostics, Gmbh 2-Azapurine compounds and their use
ATE237399T1 (de) 1999-09-29 2003-05-15 Tecan Trading Ag Thermocycler sowie hebeelement für mikrotiterplatte
GB9923144D0 (en) * 1999-09-30 1999-12-01 Socrates Biotech International Methods
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US20030082616A1 (en) * 1999-10-15 2003-05-01 Hitachi, Ltd. Apparatus and method for analyzing nucleic acids and related genetic abnormality
EP1230387B1 (de) 1999-10-22 2006-08-16 The Public Health Research Institute of the City of New York, Inc. Nachweisverfahren für kurze sequenzvarianten
US7838225B2 (en) * 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
WO2001037291A1 (en) * 1999-11-17 2001-05-25 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
AU1777401A (en) * 1999-11-17 2001-05-30 Xiuli Chen Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
WO2001038585A2 (en) * 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
EP1250452A1 (de) 1999-12-02 2002-10-23 DNA Sciences, Inc. Verfahren zur bestimmung der variation einzelner nukleotide und genotypisierung
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US7250252B2 (en) * 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
AU2001234595A1 (en) 2000-01-26 2001-08-07 University Of Cincinnati Detection of nucleic acid target sequences by electron paramagnetic resonance spectroscopy
DE10004147A1 (de) * 2000-01-31 2001-08-09 Gsf Forschungszentrum Umwelt Oligonukleotide zur spezifischen Amplifikation und zum spezifischen Nachweis von 16S-rRNA-Genen von Bakterien
US7169355B1 (en) * 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
US7033763B2 (en) * 2000-02-23 2006-04-25 City Of Hope Pyrophosphorolysis activated polymerization (PAP)
US6534269B2 (en) * 2000-02-23 2003-03-18 City Of Hope Pyrophosphorolysis activated polymerization (PAP): application to allele-specific amplification and nucleic acid sequence determination
US20030117705A1 (en) * 2000-02-25 2003-06-26 Cambridge Research & Instrumentation Inc. Fluorescence polarization assay system and method
EP1944310A3 (de) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Modifizierte Oligonukleotide zur Erkennung von Fehlanpassungen
JP2003525292A (ja) 2000-03-01 2003-08-26 エポック・バイオサイエンシーズ・インコーポレイテッド ミスマッチ識別のための修飾オリゴヌクレオチド
CA2374393A1 (en) * 2000-03-23 2001-09-27 Lumigen, Inc. Methods of detecting polynucleotide kinase and its use as a label
EP1950313A3 (de) 2000-03-27 2010-12-08 GlaxoSmithKline LLC Detektion von lebensfähigen Agenzien
US7998673B2 (en) * 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
WO2001090417A2 (en) * 2000-05-19 2001-11-29 Eragen Biosciences, Inc. Materials and methods for detection of nucleic acids
US6977161B2 (en) * 2000-10-14 2005-12-20 Eragen Biosciences, Inc. Solid support assay systems and methods utilizing non-standard bases
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6719949B1 (en) * 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
AU2001269292A1 (en) * 2000-07-07 2002-01-21 Helen Lee Improved stability of hybridisation interactions in dipstick assays
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
WO2002012263A1 (en) * 2000-08-03 2002-02-14 Roche Diagnostics Gmbh Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
US6358679B1 (en) 2000-08-24 2002-03-19 Pe Corporation (Ny) Methods for external controls for nucleic acid amplification
AUPR050700A0 (en) * 2000-10-03 2000-10-26 Id+Plus Ltd Detection method
AU2001291513B2 (en) * 2000-10-03 2007-06-07 Id+Plus Ltd Nucleotide detection method
JP2002369700A (ja) * 2000-10-11 2002-12-24 Internatl Reagents Corp 核酸分析方法
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
IL155450A0 (en) * 2000-10-20 2003-11-23 Expression Diagnostics Inc Leukocyte expression profiling
JP2002125687A (ja) * 2000-10-30 2002-05-08 Tosoh Corp Ｈｉｖ−１検出のためのオリゴヌクレオチドおよび検出法
EP1341929A2 (de) * 2000-11-15 2003-09-10 Third Wave Technologies, Inc. Fen endonukleasen
US7309573B2 (en) * 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7157232B2 (en) * 2000-12-13 2007-01-02 The Regents Of The University Of California Method to detect the end-point for PCR DNA amplification using an ionically labeled probe and measuring impedance change
WO2002063049A2 (en) * 2001-02-02 2002-08-15 Genome Therapeutics Corporation Methods for determining a nucleotide at a specific location within a nucleic acid molecule
WO2002064833A1 (fr) * 2001-02-15 2002-08-22 Takara Bio Inc. Procede de detection de polymorphisme de nucleotide
EP1236804A1 (de) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Nukleinsäuren mittels einer Kontrolle
US6713620B2 (en) * 2001-03-28 2004-03-30 Council Of Scientific And Industrial Research Oligonucleotide primers for phosphotidyl inositol in bacillus cereus
US7329223B1 (en) * 2001-05-31 2008-02-12 Abbott Cardiovascular Systems Inc. Catheter with optical fiber sensor
US7532920B1 (en) 2001-05-31 2009-05-12 Advanced Cardiovascular Systems, Inc. Guidewire with optical fiber
CA2348042A1 (en) 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6825927B2 (en) * 2001-06-15 2004-11-30 Mj Research, Inc. Controller for a fluorometer
US9261460B2 (en) * 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
EP1275735A1 (de) * 2001-07-11 2003-01-15 Roche Diagnostics GmbH Zusammensetzung und Methode zur 'Hot start' Nukleinsäureamplifizierung
AU2002365028A1 (en) * 2001-07-17 2003-06-30 Stratagene Methods for detection of a target nucleic acid using multi-subunit probes
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
WO2003033741A1 (en) * 2001-10-16 2003-04-24 Aclara Biosciences, Inc. Universal e-tag primer and probe compositions and methods
WO2003043402A2 (en) 2001-10-19 2003-05-30 Proligo Llc Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
DE10153829A1 (de) * 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7163790B2 (en) 2001-11-28 2007-01-16 Bio-Rad Laboratories, Inc. Parallel polymorphism scoring by amplification and error correction
EP1463796B1 (de) 2001-11-30 2013-01-09 Fluidigm Corporation Mikrofluidische vorrichtung und verfahren zu ihrer verwendung
US7223538B2 (en) * 2001-12-14 2007-05-29 Ge Healthcare Bio-Sciences Ab Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays
US7198897B2 (en) * 2001-12-19 2007-04-03 Brandeis University Late-PCR
JP4148900B2 (ja) 2002-01-08 2008-09-10 エフ．ホフマン−ラ ロシュ アーゲー 増幅反応におけるシリカ物質の使用
AU2003208959A1 (en) * 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
AU2003225629A1 (en) * 2002-02-27 2003-09-09 University Of Delaware Molecular markers for identification of fat and lean phenotypes in chickens
EP1340818A1 (de) * 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
HUP0200981A3 (en) * 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
EP1498486A4 (de) * 2002-03-29 2005-08-03 Prec System Science Co Ltd Nukleinsäurebibliothek und proteinbibliothek
US7445893B2 (en) * 2002-04-12 2008-11-04 Primera Biosystems, Inc. Sampling method for amplification reaction analysis
US7081339B2 (en) * 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
US7745180B2 (en) 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
WO2003100095A1 (fr) * 2002-05-08 2003-12-04 Arkray, Inc. Procede de detection d'un acide nucleique cible
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
US6896727B2 (en) * 2002-06-28 2005-05-24 Seh America, Inc. Method of determining nitrogen concentration within a wafer
KR101038137B1 (ko) * 2002-06-28 2011-05-31 프리메라디엑스, 인크. 서열 차이를 감지하는 방법
US20040023220A1 (en) * 2002-07-23 2004-02-05 Lawrence Greenfield Integrated method for PCR cleanup and oligonucleotide removal
FR2842827B1 (fr) * 2002-07-26 2004-10-22 Biocortech NOUVELLE METHODE D'ANALYSE D'ACIDE NUCLEIQUE ET SON UTILISATION POUR EVALUER LE DEGRE D'EDITION DE L'ARNm DU RECEPTEUR 5-HT2c
EP2385139A1 (de) 2002-07-31 2011-11-09 University of Southern California Polymorphismen zur Vorhersage des Krankheits- und Behandlungsausgangs
AU2003236461B2 (en) * 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
CA2498320A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7245789B2 (en) * 2002-10-07 2007-07-17 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
FI113549B (fi) * 2002-11-19 2004-05-14 Mobidiag Oy Diagnostinen menetelmä hengitystieinfektioita aiheuttavien bakteerien osoittamiseksi ja tunnistamiseksi ja menetelmässä käyttökelpoinen alukeseos
US20050089875A1 (en) * 2002-11-21 2005-04-28 Sention Inc. Quantitative analysis of expression profiling information produced at various stages of an amplification process
JP4898119B2 (ja) * 2002-11-22 2012-03-14 エフ．ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
US20040248085A1 (en) * 2002-11-29 2004-12-09 Sang-Wha Lee General primers and process for detecting diverse genotypes of human papillomavirus by PCR
EP3000899A1 (de) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplexverstärkung von polynucleotiden
CA2507240C (en) 2002-12-06 2011-05-24 F. Hoffmann-La Roche Ag Multiplex assay detection of pathogenic organisms
EP1426447A1 (de) * 2002-12-06 2004-06-09 Roche Diagnostics GmbH Verfahren zur Detection des pathogenen gram positiven Bacterien, Bvw. Staphylococcus, Enterococcus and Streptococcus
WO2004052606A2 (en) * 2002-12-06 2004-06-24 Innogenetics N.V. Detection, identification and differentiation of eubacterial taxa using a hybridization assay
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
CA2886504C (en) 2002-12-20 2019-01-08 Celera Corporation Wdr12 polymorphisms associated with myocardial infarction, methods of detection and uses thereof
ATE386141T1 (de) * 2002-12-20 2008-03-15 Stratagene Inc Zusammensetzungen und verfahren für den nachweis von polynukleotiden
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
ATE417129T1 (de) * 2003-01-17 2008-12-15 Eragen Biosciences Inc Nukleinsäureamplifikation mit nichtstandardbasen
ATE373673T1 (de) * 2003-01-29 2007-10-15 Hoffmann La Roche Verbessertes verfahren zur behandlung durch bisulfit
JP2006522329A (ja) * 2003-03-07 2006-09-28 ラクセル・バイオサイエンシズ・リミテッド 酸素感受性プローブ
US20060192960A1 (en) * 2003-03-24 2006-08-31 Rencs Erik V Polarization detection
BRPI0408967B8 (pt) 2003-03-31 2021-07-27 Hoffmann La Roche kit e métodos para detecção de um ácido nucléico de vários membros do sorogrupo do vírus da encefalite japonesa em uma amostra biológica sob condições de hibridização rigorosas
CA2521127C (en) 2003-04-01 2014-05-27 Eragen Biosciences, Inc. Polymerase inhibitor and method of using same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
US7820030B2 (en) * 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US20040214176A1 (en) * 2003-04-22 2004-10-28 Osborne James C. Multiplexed DNA assays using structure-specific endonucleases
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20070248978A1 (en) * 2006-04-07 2007-10-25 Expression Diagnostics, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US20060263813A1 (en) * 2005-05-11 2006-11-23 Expression Diagnostics, Inc. Methods of monitoring functional status of transplants using gene panels
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
CA2526617C (en) 2003-05-20 2015-04-28 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
DE10327756B4 (de) * 2003-06-18 2005-12-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zum Echtzeit-Quantifizieren einer Nukleinsäure
US20070269803A1 (en) * 2003-06-26 2007-11-22 Khalil Arar Fluorogenic Nucleic Acid Probes Including Lna for Methods to Detect and/or Quantify Nucleic Acid Analytes
US20050233314A1 (en) * 2003-06-30 2005-10-20 National Health Research Institutes Sensitive and quantitative detection of pathogens by real-time nested PCR
GB0317592D0 (en) * 2003-07-26 2003-08-27 Astrazeneca Ab Method
WO2005010183A1 (ja) 2003-07-29 2005-02-03 Otsuka Pharmaceutical Co., Ltd. 薬剤起因性顆粒球減少症発症リスク判定法
EP1502958A1 (de) * 2003-08-01 2005-02-02 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
EP1502961B1 (de) * 2003-08-01 2010-09-08 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
EP1704246A4 (de) * 2003-09-30 2007-11-28 Perkinelmer Las Inc Zusammensetzungen und verfahren zur genotypisierung von einzelnukleotidpolymorphismen
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
CA2482097C (en) * 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
ES2382780T3 (es) 2003-10-21 2012-06-13 Orion Genomics, Llc Procedimientos para la determinación cuantitativa de la densidad de metilación en un locus de ADN
WO2005045058A2 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
CA2542768A1 (en) * 2003-10-28 2005-05-12 Epoch Biosciences, Inc. Fluorescent probes for dna detection by hybridization with improved sensitivity and low background
EP1682903A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung zwischen aml-spezifischen flt3 längenmutationen und tkd mutationen
US20070128607A1 (en) * 2003-11-04 2007-06-07 Martin Dugas Method for distinguishing aml subtypes with different gene dosages
US20070207459A1 (en) * 2003-11-04 2007-09-06 Martin Dugas Method For Distinguishing Immunologically Defined All Subtype
WO2005043161A2 (en) * 2003-11-04 2005-05-12 Roche Diagnostics Gmbh Method for distinguishing leukemia subtypes
EP1533618A1 (de) * 2003-11-04 2005-05-25 Ludwig-Maximilians-Universität München Methode zur Unterscheidung prognostisch definierbarer AML
EP1682902A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung von mll-ptd positiven aml von anderen aml subtypen
WO2005043164A2 (en) * 2003-11-04 2005-05-12 Roche Diagnostics Gmbh Method for distinguishing cbf-positive aml subtypes from cbf-negative aml subtypes
US20070105118A1 (en) * 2003-11-04 2007-05-10 Martin Dugas Method for distinguishing aml subtypes with recurring genetic aberrations
EP1530046A1 (de) * 2003-11-04 2005-05-11 Ludwig-Maximilians-Universität München Methode zur Unterscheidung von AML Subtypen mit verändertem Karyotyp mit mittelmässiger Prognose
EP1682900A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung von t(11q23)/mll positiven leukemien von t(11q23)/mll negativen leukemien
US20050261841A1 (en) * 2003-11-07 2005-11-24 Shepard Donald F Physical geolocation system
JP4912151B2 (ja) * 2003-11-12 2012-04-11 バイエル・ヘルスケア・エルエルシー 西ナイルウイルスを検出するためのオリゴヌクレオチドおよび方法
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
WO2005051967A2 (en) * 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
EP1706502A4 (de) * 2003-11-26 2007-05-23 Eppendorf Ag Verfahren und zusammensetzungen zur in-vitro-amplifikation extrachromosomaler nukleinsäure
CA3050151C (en) 2003-11-26 2023-03-07 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
WO2005054502A1 (en) 2003-12-02 2005-06-16 Roche Diagnostics Gmbh Improved method for bisulfite treatment
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
MX2009009225A (es) 2003-12-23 2009-09-28 Cythera Inc Endodermo definitivo.
US20050208539A1 (en) * 2003-12-31 2005-09-22 Vann Charles S Quantitative amplification and detection of small numbers of target polynucleotides
WO2005067646A2 (en) 2004-01-07 2005-07-28 Hitachi Chemical Research Center, Inc. Primers and probes for the detection of hiv
CA2553270C (en) * 2004-02-06 2016-08-23 Innogenetics N.V. Detection, identification and differentiation of proteus species using the spacer region
ATE485401T1 (de) * 2004-02-10 2010-11-15 Hoffmann La Roche Neue primer und sonden zum nachweis von parvovirus b19
JP2007525218A (ja) * 2004-02-19 2007-09-06 ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク 生物学的に活性な化合物の検出
EP1721011A1 (de) 2004-03-01 2006-11-15 Applera Corporation Verfahren, zusammensetzungen und kits zur verwendung bei der polynukleotidamplifikation
WO2005092038A2 (en) * 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
KR100906749B1 (ko) * 2004-03-25 2009-07-09 (주)바이오니아 인터컬레이팅 형광염료가 표지된 프로브를 이용한 핵산 증폭 측정 방법
AU2005230833B2 (en) * 2004-04-01 2011-04-14 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity
CA2561565C (en) * 2004-04-08 2013-11-26 Sangamo Biosciences, Inc. Methods for repression of phospholamban gene and modulating cardiac contractility
EP1732614B1 (de) * 2004-04-08 2008-12-24 Sangamo Biosciences Inc. Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen
ES2560433T3 (es) 2004-04-26 2016-02-19 Wako Pure Chemical Industries, Ltd. Cebadores para la detección del bacilo de la tuberculosis y procedimiento de detección del bacilo de la tuberculosis humana con los mismos
US7939251B2 (en) * 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
EP1745154B1 (de) 2004-05-07 2012-08-01 Celera Corporation Genetische polymorphismen assoziiert mit leberfibrose, verfahren zur detektion und verwendung davon
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
JP4545147B2 (ja) * 2004-05-17 2010-09-15 株式会社日立国際電気 基板処理装置及び半導体デバイス製造方法
US20080261207A1 (en) * 2004-05-25 2008-10-23 Masato Mitsuhashi Method of Measuring Cancer Susceptibility
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
US7622296B2 (en) * 2004-05-28 2009-11-24 Wafergen, Inc. Apparatus and method for multiplex analysis
CN102680440A (zh) 2004-06-07 2012-09-19 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
EP1609871A1 (de) * 2004-06-21 2005-12-28 Biolytix AG Verfahren und Kits zur Detektion, Identifizierung und Quantifizierung von Bacterien und Hefen in Lebensmitteln und Getränken.
EP2453024B1 (de) 2004-06-21 2017-12-06 The Board of Trustees of The Leland Stanford Junior University Differenziell exprimierte Gene und Leitungsbahnen bei bipolarer Störung und/oder schwerer depressiver Erkrankung
US20070154889A1 (en) * 2004-06-25 2007-07-05 Veridex, Llc Methods and reagents for the detection of melanoma
US20060216715A1 (en) * 2004-06-28 2006-09-28 Jun Nakayama Method of detecting cancer
US7745125B2 (en) 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
EP1781810A1 (de) * 2004-06-29 2007-05-09 Wallac Oy Integrierte nichthomogene nukleinsäureamplifikation und -detektion
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
WO2006085964A2 (en) * 2004-06-30 2006-08-17 Applera Corporation Log-linear amplification
US7399614B2 (en) * 2004-06-30 2008-07-15 Applera Corporation 5-methylcytosine detection, compositions and methods therefor
AU2005267148A1 (en) 2004-07-01 2006-02-02 University Of Southern California Genetic markers for predicting disease and treatment outcome
TWI334885B (en) * 2004-07-05 2010-12-21 Food And Drug Administration Dept Of Health Primers, probes and reference plasmid for detection of meat
WO2006006722A1 (ja) 2004-07-13 2006-01-19 Takeda Pharmaceutical Company Limited 細胞機能の調節方法
EP1627921B1 (de) * 2004-08-18 2008-08-27 Roche Diagnostics GmbH Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
EP1632578A1 (de) 2004-09-03 2006-03-08 Roche Diagnostics GmbH Methode zur Dekontamination der DNA
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1634965B1 (de) 2004-09-09 2010-01-20 Roche Diagnostics GmbH Echtzeit-PCR unter Zusatz von Pyrophosphatase
US20060051796A1 (en) * 2004-09-09 2006-03-09 Inga Boell Real time PCR with the addition of pyrophosphatase
US8969379B2 (en) 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
EP1791982B1 (de) * 2004-09-21 2011-01-05 Life Technologies Corporation Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
JP5210634B2 (ja) * 2004-09-30 2013-06-12 イノジェネティックス・ナムローゼ・フェンノートシャップ スペーサー領域を使用するセラチア（Ｓｅｒｒａｔｉａ）種の検出、同定および鑑別
US7166680B2 (en) * 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
BRPI0516619B1 (pt) * 2004-10-18 2016-02-10 Univ Brandeis reagentes, kit de reagentes e conjunto de oligonucleotídeos para realização de uma amplificação por reação em cadeia de polimerase
EP2927238B1 (de) * 2004-10-18 2018-01-17 Brandeis University Verfahren zur LATE Amplifikation und Sequenzierung von Nukleinsäuren
US20060147954A1 (en) * 2004-10-19 2006-07-06 Wallac Oy Novel probe and its use in bioaffinity assays
EP1802776B1 (de) * 2004-10-20 2013-01-02 Hitachi Chemical Company, Ltd. Verfahren zur anpassung der arzneimittelverabreichung durch quantifizierung von mrna
WO2006045392A2 (en) 2004-10-21 2006-05-04 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Kaspp (lrrke) gene, its production and use for the detection and treatment of neurodegenerative disorders
CN100441696C (zh) * 2004-10-22 2008-12-10 中国疾病预防控制中心传染病预防控制所 肠出血性大肠杆菌o157：h7菌株的检测方法
JP4999103B2 (ja) 2004-10-27 2012-08-15 セフィード 閉鎖系の多段階核酸増幅反応
JP5078358B2 (ja) 2004-10-28 2012-11-21 大塚製薬株式会社 腎細胞癌に対するインターフェロン治療反応性識別マーカー
CA2587670A1 (en) 2004-11-01 2006-05-11 George Mason University Compositions and methods for diagnosing colon disorders
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
EP1666150B1 (de) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Präparieren von Nucleinsäuren
KR20070090233A (ko) * 2004-12-08 2007-09-05 타케시 야마모토 유전자 서열 검사법
WO2008101133A2 (en) * 2007-02-14 2008-08-21 Cedars-Sinai Medical Center Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
WO2010048415A1 (en) * 2008-10-22 2010-04-29 Cedars-Sinai Medical Center Methods of using jak3 genetic variants to diagnose and predict crohn's disease
CA3204588A1 (en) * 2004-12-08 2006-06-15 Cedars-Sinai Medical Center Methods for diagnosis and treatment of crohn's disease
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
US20060178507A1 (en) * 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
US20060252032A1 (en) * 2005-01-28 2006-11-09 Third Wave Technologies, Inc. Detection of human herpesviruses
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006094106A2 (en) * 2005-02-28 2006-09-08 Sangamo Biosciences, Inc. Anti-angiogenic methods and compositions
US7521188B2 (en) * 2005-03-02 2009-04-21 The Regents Of The University Of Michigan Optical monitoring of cleaving enzyme activity
EP2348320B1 (de) 2005-03-10 2024-05-01 Gen-Probe Incorporated Verfahren und Systeme zur Erkennung mehrerer Fluoreszenzemissionssignale
CA2842232C (en) 2005-03-10 2015-01-27 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
US7776567B2 (en) 2005-03-17 2010-08-17 Biotium, Inc. Dimeric and trimeric nucleic acid dyes, and associated systems and methods
US7601498B2 (en) * 2005-03-17 2009-10-13 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection and associated technology
EP1861512A4 (de) 2005-03-18 2009-12-09 Fluidigm Corp Wärmereaktionsvorrichtung und verwendungsverfahren dafür
WO2006101913A2 (en) * 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of neiserria
EP1710016A3 (de) 2005-03-30 2011-03-30 Roche Diagnostics GmbH Vorrichtung mit selbstdichtendem Einlass
US20060275798A1 (en) * 2005-04-04 2006-12-07 Steichen John C Detection of organisms using a media sachet and primer directed nucleic acid amplification
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
EP1888089B9 (de) * 2005-04-28 2012-08-08 Hitachi Chemical Research Center, Inc. Ex-vivo-genexpression in vollblut als modell für die beurteilung von individueller variation gegenüber nahrungszusätzen
US20070015180A1 (en) * 2005-05-02 2007-01-18 Stratagene California Oligonucleotide probe/primer compositions and methods for polynucleotide detection
JP5076894B2 (ja) 2005-05-13 2012-11-21 和光純薬工業株式会社 マイコバクテリウム・カンサシ検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・カンサシの検出方法
WO2006127507A2 (en) * 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
CA2919210C (en) 2005-06-07 2019-03-05 Luminex Corporation Methods for detection and typing of nucleic acids
CN101194027B (zh) * 2005-06-08 2012-10-24 日立化成研究中心公司 用于基于瘤细胞及受刺激的白细胞内mRNA表达谱而预测对肿瘤疾病的免疫应答的方法
WO2006135765A1 (en) * 2005-06-09 2006-12-21 Epoch Biosciences, Inc. Improved primer-based amplification methods
US7423194B2 (en) * 2005-06-14 2008-09-09 University Of Chicago Animal models for demyelination disorders
US8053627B2 (en) * 2005-06-14 2011-11-08 University Of Chicago Methods for treating demyelination disorders
US7884260B2 (en) * 2005-06-14 2011-02-08 University Of Chicago Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
US20060292577A1 (en) * 2005-06-27 2006-12-28 Purdue Research Foundation Neoplasia-specific splice variants and methods
US20060292578A1 (en) 2005-06-28 2006-12-28 Weidong Zheng DNA polymerase blends and mutant DNA polymerases
US7919242B2 (en) 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
WO2007008693A2 (en) * 2005-07-09 2007-01-18 Lovelace Respiratory Research Institute Gene methylation as a biomarker in sputum
US20070020671A1 (en) * 2005-07-12 2007-01-25 Radtkey Ray R Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes
US7977108B2 (en) * 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence
BRPI0614445B8 (pt) 2005-07-26 2021-07-27 Merck & Co Inc ensaio de ácido nucleico para resistência de fármaco de equinocandina em fungos suscetíveis aos fármacos de equinocandina e contendo o gene fks1 que corresponde a subunidade fks1p 1,3-?-d-glicano sintase, bem como conjunto de oligonucleotídeos e kit de reagentes de amplificação
WO2007015578A1 (ja) 2005-08-02 2007-02-08 Eisai R & D Management Co., Ltd. 血管新生阻害物質の効果を検定する方法
WO2007019410A2 (en) * 2005-08-05 2007-02-15 The Board Of Trustees Of The Leland Stanford Junior University Mammalian obestatin receptors
ES2494922T3 (es) * 2005-09-01 2014-09-16 Ausdiagnostics Pty Ltd. Métodos para la amplificación, cuantificación e identificación de ácidos nucleicos
DE602005021967D1 (de) 2005-09-06 2010-08-05 Roche Diagnostics Gmbh Vorrichtung mit komprimierbarer Matrix und homogenem Strömungsprofil
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7741467B2 (en) * 2005-10-05 2010-06-22 Roche Molecular Systems, Inc. Non-fluorescent energy transfer
EP2546360A1 (de) 2005-10-07 2013-01-16 Callida Genomics, Inc. Selbstangeordnete einzelne Molekülarrays und Verwendungen davon
US7838221B2 (en) 2005-10-11 2010-11-23 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US20070084706A1 (en) * 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
US20070092904A1 (en) * 2005-10-19 2007-04-26 Biogen Idec Ma Inc. Method for preparing limiting quantities of nucleic acids
US7781165B2 (en) 2005-10-19 2010-08-24 Roche Diagnostics Operations, Inc. Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
ES2775049T3 (es) 2005-10-21 2020-07-23 Univ California Mutaciones del gen SHP-2 en melanomas
CA2528222A1 (en) * 2005-10-31 2007-04-30 Centre For Addiction And Mental Health Slc1a1 marker for anxiety disorder
EP1945818B1 (de) * 2005-11-07 2018-01-03 Siemens Healthcare Diagnostics Inc. Chlamydia trachomatis spezifische oligonukleotide
WO2007059064A2 (en) 2005-11-12 2007-05-24 The Board Of Trustees Of The Leland Stanford Junior University Fgf2-related methods for diagnosing and treating depression
WO2007120208A2 (en) * 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
ES2332139T3 (es) 2005-11-23 2010-01-27 F. Hoffmann-La Roche Ag Polinucleotidos con mimetico de fosfato.
CN103710430B (zh) 2005-11-29 2016-03-30 剑桥企业有限公司 乳腺癌标志物
EP1798650A1 (de) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytisches Verfahren und Instrument
EP1798542A1 (de) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytisches Verfahren und Gerät
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
DK1994171T3 (en) 2006-01-17 2015-06-15 Somalogic Inc Multiplex Analyses of test samples
WO2007090397A2 (en) * 2006-02-06 2007-08-16 Aarhus Universitet Qtls for udder health characteristics in cattle
WO2007092538A2 (en) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
US20090181386A1 (en) * 2006-02-08 2009-07-16 Kvaegavlsforeningen Dansire Calving Characteristics
CA2638854C (en) * 2006-02-27 2012-05-15 F. Hoffmann-La Roche Ag Pcr hot start by magnesium sequestration
JP2009528063A (ja) * 2006-03-01 2009-08-06 パーレジェン サイエンシーズ， インコーポレイテッド 依存症に対するマーカー
CN101400806A (zh) 2006-03-13 2009-04-01 和光纯药工业株式会社 突变基因的检测方法
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
AU2007235282A1 (en) * 2006-04-07 2007-10-18 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae specific oligonucleotide sequences
US20070264694A1 (en) * 2006-04-07 2007-11-15 Eragen Biosciences, Inc. Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis
US7838239B2 (en) * 2006-04-07 2010-11-23 Hitachi Chemical Co., Ltd. Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease
JP2009536021A (ja) * 2006-04-07 2009-10-08 日立化成工業株式会社 関節リウマチの患者の末梢血白血球におけるＦＣ受容体媒介性腫瘍壊死因子スーパーファミリ及びケモカインのｍＲＮＡ発現の増大
EP2016188B1 (de) * 2006-04-24 2015-10-21 Xiyu Jia Verfahren zum nachweis methylierter dna
EP2021510A2 (de) * 2006-04-28 2009-02-11 Biogen Idec MA Inc. Zusammensetzung und verfahren für den nachweis von cripto-3
EP2021506B1 (de) * 2006-04-28 2016-03-16 Igor Kutyavin Verwendung von pcr-amplifikationsprodukten mit elementen sekundärer struktur für verbesserten pcr-basierten nukleinsäurenachweis
US8349556B2 (en) 2006-04-28 2013-01-08 Igor Kutyavin Use of base-modified deoxynucleoside triphosphates to improve nucleic acid detection
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
EP2011871A4 (de) 2006-05-02 2010-01-27 Wako Pure Chem Ind Ltd Primer und sonde zum nachweis von mycobacterium intracellulare und verfahren zum nachweis von mycobacterium intracellulare unter verwendung des primers und der sonde
WO2007133551A2 (en) * 2006-05-08 2007-11-22 Hitachi Chemical Co., Ltd. Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue
US20070264639A1 (en) * 2006-05-10 2007-11-15 Sigma Aldrich, Co. Identification of Echinacea and its imposters using genetic variations
US20070264638A1 (en) * 2006-05-10 2007-11-15 Sigma-Aldrich Co. Identification of ginseng and its imposters using genetic variations
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
EP2027251A4 (de) 2006-05-17 2010-05-05 California Inst Of Techn Thermisches wechselbeanspruchungssystem
CA2652442C (en) 2006-05-18 2014-12-09 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
CA2653321A1 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc. Biochemical analysis of partitioned cells
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
PL2017356T3 (pl) 2006-06-06 2012-03-30 Gen Probe Inc Znakowane oligonukleotydy i ich zastosowanie w sposobach amplifikacji kwasu nukleinowego
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
EP1886727A1 (de) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Vorrichtung zur Analyse
US7915014B2 (en) 2006-07-17 2011-03-29 Brandeis University Specialized oligonucleotides and their use in nucleic acid amplification and detection
US7772390B1 (en) 2006-07-18 2010-08-10 The Regents Of The University Of California Lipid mediated nucleic acid synthesis
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
WO2008019319A2 (en) * 2006-08-04 2008-02-14 Ikonisys, Inc. Improved slide holder for staining procedures
US7993832B2 (en) * 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008021446A2 (en) * 2006-08-15 2008-02-21 Genetag Technology, Inc. Probe-antiprobe compositions and methods for dna or rna detection
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
KR101472600B1 (ko) 2006-08-28 2014-12-15 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암에 대한 항종양제
EP1900824A1 (de) * 2006-09-14 2008-03-19 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Genexpressionsprofile zur Prognose, Diagnose und Therapie von Prostatakrebs und deren Verwendung
US7947487B2 (en) 2006-10-05 2011-05-24 Massachusetts Institute Of Technology Multifunctional encoded particles for high-throughput analysis
EP1914303A1 (de) * 2006-10-09 2008-04-23 Qiagen GmbH Thermus eggertssonii DNA Polymerasen
CA2915679C (en) 2006-10-20 2017-12-12 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
GB0621864D0 (en) 2006-11-02 2006-12-13 Univ Manchester Assay for fungal infection
WO2008140484A2 (en) * 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7902345B2 (en) * 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
JP5354894B2 (ja) * 2006-12-11 2013-11-27 エフ．ホフマン−ラ ロシュ アーゲー ポリドカノールおよび誘導体を用いた核酸単離
EP1932913B1 (de) 2006-12-11 2013-01-16 Roche Diagnostics GmbH Nukleinsäureisolation mithilfe von Polidocanol und Derivaten davon
EP2857526B1 (de) 2006-12-13 2016-08-17 Luminex Corporation Systeme und Verfahren zur Multiplexanalyse von PCR in Echtzeit
WO2008076375A2 (en) * 2006-12-13 2008-06-26 Autogenomics, Inc. Concurrent analysis of multiple patient samples using solid phase addressable multiplex test with high signal-to-noise ratio
CN103397024B (zh) 2006-12-18 2015-11-25 和光纯药工业株式会社 鸟分枝杆菌检测用引物和探针、以及使用它们检测鸟分枝杆菌的方法
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
US8518646B2 (en) 2006-12-19 2013-08-27 Geneohm Sciences, Inc. Detection of Staphylococcus aureus and identification of methicillin-resistant Staphylococcus aureus
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
US20080241838A1 (en) * 2006-12-29 2008-10-02 Applera Corporation, Applied Biosystems Group Methods and systems for detecting nucleic acids
AU2007339793A1 (en) * 2006-12-29 2008-07-10 Applied Biosystems, Llc Systems and methods for detecting nucleic acids
AU2008205457A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual TKI therapy
WO2008091626A1 (en) 2007-01-22 2008-07-31 Wafergen, Inc. Apparatus for high throughput chemical reactions
CA2676796C (en) 2007-01-29 2016-02-23 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
EP2520668B1 (de) 2007-01-31 2014-12-24 Celera Corporation Molekulare Prognosesignatur zur Prognose entfernter Brustkrebsmetastasen und Anwendungen davon
ES2665690T3 (es) 2007-02-02 2018-04-26 Genera Biosystems Limited Generación de moléculas de ácido nucleico
WO2008098142A2 (en) 2007-02-08 2008-08-14 Sequenom, Inc. Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
US20100190162A1 (en) * 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2008137762A2 (en) * 2007-05-04 2008-11-13 Cedars-Sinai Medical Center Methods of diagnosis and treatment of crohn's disease
GB0703996D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Nucleic acid detection
GB0703997D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
DE102007013099A1 (de) 2007-03-14 2008-09-18 Aj Innuscreen Gmbh Verfahren und Testkit zum schnellen Nachweis spezifischer Nukleinsäuresequenzen, insbesondere zum Nachweis von Mutationen oder SNP's
US8486640B2 (en) 2007-03-21 2013-07-16 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease
AU2008230813B2 (en) 2007-03-26 2014-01-30 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
DK2574681T3 (en) 2007-03-28 2016-07-04 Signal Diagnostics System and method for high-resolution analysis of nucleic acids to detect sequence variations
JP5191041B2 (ja) * 2007-04-05 2013-04-24 エフ．ホフマン−ラ ロシュ アーゲー 急速ワンステップｒｔ−ｐｃｒ
EP2385119B1 (de) 2007-04-06 2015-11-11 Janssen Diagnostics BVBA Test für den Nachweis von Respiratory Syncytial Virus (RSV)-Viruslast
US9290803B2 (en) * 2007-04-12 2016-03-22 University Of Southern California DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight
EP2514838B1 (de) 2007-04-13 2017-12-06 Abbott Molecular Inc. Primer- und Sondensequenzen zur Detektion von Chlamydia Trachomatis
EP2150625B1 (de) 2007-04-19 2013-03-20 Molecular Detection Inc. Verfahren, zusammensetzungen und kits zur erkennung und analyse von antibiotika-resistenten bakterien
WO2008134569A2 (en) * 2007-04-26 2008-11-06 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
ATE524566T1 (de) * 2007-05-04 2011-09-15 Myconostica Ltd Nachweis von triazolresistenz bei aspergillus
WO2008153804A2 (en) * 2007-05-31 2008-12-18 Monsanto Technology Llc Soybean polymorphisms and methods of genotyping
EP2527472B1 (de) 2007-05-31 2016-09-28 Yale University Mit Krebs assoziierte genetische Läsion
EP2617837A3 (de) 2007-06-08 2013-10-23 Biogen Idec MA Inc. Biomarker zur Vorhersage des Ansprechens oder Nichtansprechens auf Anti-TNF
ES2959127T3 (es) 2007-06-19 2024-02-20 Hoffmann La Roche Secuenciación de ácidos nucleicos de alto rendimiento por expansión
CA2691451C (en) 2007-06-21 2015-03-24 Sara H. Fan Instrument and receptacles for performing processes
DE102007029772B4 (de) 2007-06-22 2011-12-08 Aj Innuscreen Gmbh Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen
US7635566B2 (en) 2007-06-29 2009-12-22 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
JP5684568B2 (ja) 2007-07-17 2015-03-11 ソマロジック・インコーポレーテッド 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法
US20090181366A1 (en) * 2007-07-30 2009-07-16 Quest Diagnostics Investments Incorporated Internal positive control for nucleic acid assays
ES2453108T3 (es) 2007-08-06 2014-04-04 Orion Genomics, Llc Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
JP2010537637A (ja) 2007-08-27 2010-12-09 アプライド バイオシステムズ インコーポレイテッド Ｐｃｒのための方法および組成物
CA2697860C (en) 2007-08-29 2019-01-15 Monsanto Technology Llc Method and compositions for breeding for preferred traits associated with goss` wilt resistance in plants
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
DE102007041864B4 (de) 2007-09-04 2012-05-03 Sirs-Lab Gmbh Verfahren zum Nachweis von Bakterien und Pilzen
WO2009033178A1 (en) 2007-09-07 2009-03-12 Fluidigm Corporation Copy number variation determination, methods and systems
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
GB2453173A (en) 2007-09-28 2009-04-01 Dxs Ltd Polynucleotide primers
CN101896623B (zh) * 2007-10-22 2013-12-18 Lgc有限公司 寡核苷酸及其应用
WO2009059022A1 (en) 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
EP2851432B1 (de) 2007-11-01 2019-01-09 University of Iowa Research Foundation RCA-Locus-Analyse zur Beurteilung der Anfälligkeit für AMD
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US20100255482A1 (en) * 2007-11-06 2010-10-07 Siemens Healthcare Diagnostics Inc. Hepatitis B Virus (HBV) Specific Oligonucleotide Sequences
EP2212437A4 (de) * 2007-11-07 2011-09-28 Univ British Columbia Mikrofluidische vorrichtung und verfahren zu ihrer anwendung
WO2009060945A1 (ja) 2007-11-09 2009-05-14 Eisai R & D Management Co., Ltd. 血管新生阻害物質と抗腫瘍性白金錯体との併用
EP2222847A1 (de) 2007-11-16 2010-09-01 E. I. du Pont de Nemours and Company Verfahren zum nachweis und/oder zur analyse von hefe und schimmel in filtrierbaren flüssigkeiten
CN102016579B (zh) 2007-11-30 2015-04-08 健泰科生物技术公司 Vegf多态性和抗血管发生疗法
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
US20090197254A1 (en) * 2007-12-14 2009-08-06 Ming-Chou Lee Variant scorpion primers for nucleic acid amplification and detection
WO2009085221A2 (en) 2007-12-21 2009-07-09 Biomerieux Sa Detection of methicillin-resistant staphylococcus aureus
US20090186344A1 (en) * 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
JPWO2009099037A1 (ja) 2008-02-08 2011-05-26 和光純薬工業株式会社 クラミドフィラ・キャビエ検出用プライマー及びプローブ、並びにこれを用いたクラミドフィラ・キャビエの検出方法
WO2009103003A2 (en) * 2008-02-15 2009-08-20 Bio-Rad Laboratories, Inc. Scanning fluorescent reader with diffuser system
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
US20110091866A1 (en) * 2008-02-20 2011-04-21 Kosuke Ken Iwaki Detection of polyomavirus
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
EP2271772B1 (de) * 2008-03-11 2014-07-16 Sequenom, Inc. Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
KR101419980B1 (ko) * 2008-03-15 2014-07-15 홀로직, 인크. 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법
CA2658520C (en) 2008-03-19 2016-11-08 F. Hoffmann-La Roche Ag Nucleic acid amplification in the presence of modified randomers
US8206926B2 (en) 2008-03-26 2012-06-26 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP2108699B1 (de) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Vorrichtung zur analytischen Verarbeitung und Detektion
US8206925B2 (en) * 2008-04-14 2012-06-26 Medical Diagnostic Laboratories, Llc Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
US9249455B2 (en) * 2008-04-18 2016-02-02 Luminex Corporation Methods for detection and quantification of small RNA
CN102098909B (zh) 2008-04-24 2014-12-31 孟山都技术有限公司 鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
US9434988B2 (en) 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644709B1 (de) 2008-04-30 2014-12-17 Integrated Dna Technologies, Inc. Rnase-h-basierte assays unter verwendung von modifizierten rna monomeren
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
EP2123360A1 (de) 2008-05-20 2009-11-25 F.Hoffmann-La Roche Ag Thermozyklierungsvorrichtung mit Thermozyklermodul mit Wärmeschutzschalter, Verfahren zur Kühlung eines Heizblocks in einem Thermozyklermodul einer Thermozyklierungsvorrichtung und Analysegerät
CN102046788B (zh) 2008-05-28 2013-07-10 和光纯药工业株式会社 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针检测胞内分枝杆菌的方法
US8208909B2 (en) 2008-06-02 2012-06-26 West Corporation System, apparatus and method for availing a mobile call of address information
EP2133434A1 (de) 2008-06-12 2009-12-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zum Nachweis von Zielnukleinsäuren
EP2235177B1 (de) * 2008-06-13 2012-07-18 RiboxX GmbH Verfahren zur enzymatischen synthese chemisch modifizierter rna
IES20090467A2 (en) * 2008-06-13 2010-03-31 Nat Univ Ireland Ace2 as a target gene for the molecular identification of yeast and fungal species.
EP2141246A1 (de) 2008-07-01 2010-01-06 Koninklijke Philips Electronics N.V. Spaltungslose Verfahren zur PCR-Erkennung mithilfe von SERRS
EP2310525B1 (de) 2008-07-09 2014-02-26 Celera Corporation Mit herz-kreislauf-erkrankungen assoziierte genetische polymorphismen, nachweisverfahren und ihre verwendung
EP2147981A1 (de) 2008-07-25 2010-01-27 Biotype AG Kit und Verfahren zur Auswertung der Detektionseigenschaften bei Verstärkungsreaktionen
GB0909333D0 (en) 2009-06-01 2009-07-15 Fu Guoliang Multiplex amplification and detection
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
JP5367078B2 (ja) 2008-08-01 2013-12-11 エフ．ホフマン−ラ ロシュ アーゲー ｍＲＮＡ定量のための改善された溶解および逆転写
ES2574137T3 (es) * 2008-09-03 2016-06-15 Quantumdx Group Limited Estrategias y métodos de detección de ácidos nucleicos mediante biosensores
WO2010028288A2 (en) 2008-09-05 2010-03-11 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US9250249B2 (en) * 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US7910720B2 (en) 2008-09-09 2011-03-22 Roche Diagnostics Operations, Inc. Polyanion for improved nucleic acid amplification
US20110171649A1 (en) * 2008-09-10 2011-07-14 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US20110177969A1 (en) * 2008-10-01 2011-07-21 Cedars-Sinai Medical Center The role of il17rd and the il23-1l17 pathway in crohn's disease
CA2682439A1 (en) 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
CN102186996A (zh) * 2008-10-20 2011-09-14 霍夫曼-拉罗奇有限公司 改进的等位基因特异性扩增
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8278041B2 (en) * 2008-10-27 2012-10-02 Infraegis, Inc. Compositions and methods for detecting food-borne pathogens
CN102203296B (zh) 2008-11-05 2014-12-03 健泰科生物技术公司 年龄相关的黄斑变性中的遗传多态性
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
GB2467704B (en) 2008-11-07 2011-08-24 Mlc Dx Inc A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
WO2010055134A1 (en) 2008-11-13 2010-05-20 Riboxx Gmbh Rna detection method
US10669574B2 (en) 2008-11-18 2020-06-02 XCR Diagnostics, Inc. DNA amplification technology
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US20110300544A1 (en) 2008-12-09 2011-12-08 Guoliang Fu Enhanced taqman probe based amplification
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
EP2367954B1 (de) 2008-12-19 2015-02-18 Life Technologies Corporation Proteinase k inhibitore, verfahren und zusammensetzungen davon
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
IT1397110B1 (it) * 2008-12-29 2012-12-28 St Microelectronics Rousset Microreattore autosigillante e metodo per eseguire una reazione
US8206929B2 (en) 2009-01-07 2012-06-26 Roche Molecular Systems, Inc. Nucleic acid amplification with allele-specific suppression of sequence variants
EA020593B1 (ru) 2009-01-13 2014-12-30 Флуидигм Корпорейшн Анализ нуклеиновых кислот, полученных из единичных клеток
PT2387627E (pt) 2009-01-15 2016-06-03 Adaptive Biotechnologies Corp Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais
JP2012516155A (ja) 2009-01-27 2012-07-19 キアゲン ゲーザーズバーグ エンドポイント均一蛍光検出を用いた好熱性ヘリカーゼ依存性増幅技術
US20120028254A1 (en) 2009-02-06 2012-02-02 Weidhaas Joanne B SNP Marker of Breast and Ovarian Cancer Risk
AU2010213727A1 (en) 2009-02-11 2011-09-29 Orion Genomics Llc Combinations of polymorphisms for determining allele-specific expression of IGF2
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
JP5457222B2 (ja) * 2009-02-25 2014-04-02 エフ．ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
JP5757885B2 (ja) 2009-03-12 2015-08-05 ブランディーズ・ユニバーシティ Ｐｃｒ用の試薬および方法
CA2755615A1 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
WO2010112033A2 (en) 2009-03-31 2010-10-07 Østjysk Innovation A/S Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
CN103952482A (zh) 2009-04-02 2014-07-30 弗卢伊蒂格姆公司 用于对目标核酸进行条形码化的多引物扩增方法
CN202830041U (zh) * 2009-04-03 2013-03-27 Illumina公司 用于加热生物样本的设备
KR101798211B1 (ko) 2009-04-07 2017-11-15 코닌클리케 필립스 엔.브이. 독소생성 클로스트리디움 디피실리 균주의 검출 및 특성 확인 방법
JPWO2010123058A1 (ja) 2009-04-22 2012-10-25 田辺三菱製薬株式会社 塩基変異判別用プローブセットおよび塩基変異の判別方法
WO2010123625A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms predict clinical outcome in patients with cancer
EP2256215A1 (de) 2009-04-30 2010-12-01 Steffen Mergemeier Testsystem unter Verwendung einer Nukleaseaktivität einer Nukleinsäurepolymerase
JP2012525147A (ja) 2009-04-30 2012-10-22 グッド スタート ジェネティクス， インコーポレイテッド 遺伝マーカーを評価するための方法および組成物
EP2248915B1 (de) * 2009-05-05 2013-09-18 Qiagen GmbH Detektion mehrerer Nukleinsäuresequenzen in einer Reaktionskartusche
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
WO2010133972A1 (en) 2009-05-22 2010-11-25 Population Genetics Technologies Ltd Sorting asymmetrically tagged nucleic acids by selective primer extension
EP2267153A1 (de) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identifizierung der Netrin-1-Rezeptor-unc5c-Genmutation bei festen Krebsen
US20110237537A1 (en) * 2009-05-29 2011-09-29 Lombard Jay L Methods for assessment and treatment of mood disorders via single nucleotide polymorphisms analysis
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
EP3663750B1 (de) 2009-05-29 2021-11-03 Life Technologies Corporation Nukleinsäuregerüstpolymerpartikel und verfahren zur herstellung und verwendung
WO2010138796A2 (en) * 2009-05-29 2010-12-02 Genomind, Llc Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8355927B2 (en) 2010-11-05 2013-01-15 Genomind, Llc Neuropsychiatric test reports
AU2010265889A1 (en) 2009-06-25 2012-01-19 Yale University Single nucleotide polymorphisms in BRCA1 and cancer risk
US20100330571A1 (en) 2009-06-25 2010-12-30 Robins Harlan S Method of measuring adaptive immunity
IL206810A (en) * 2009-07-08 2015-07-30 Janssen Diagnostics Llc Methods for identifying melanoma and kits for using these methods
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
WO2011008640A1 (en) 2009-07-14 2011-01-20 Beth Israel Deaconess Medical Center, Inc. Methods of increasing liver proliferation
CA2768794C (en) 2009-07-22 2018-09-18 E. I. Du Pont De Nemours And Company Sequences and their use for detection and characterization of e. coli o157:h7
EP2464754B1 (de) * 2009-08-13 2014-03-12 Life Technologies Corporation Amelogenin-snp auf x-chromosomen
EP2467479B1 (de) 2009-08-20 2016-01-06 Population Genetics Technologies Ltd Zusammensetzungen und verfahren für intramolekulare neuanordnung von nukleinsäuren
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
WO2011031377A1 (en) 2009-09-09 2011-03-17 Helixis, Inc. Optical system for multiple reactions
WO2011030091A1 (en) 2009-09-11 2011-03-17 Myconostica Limited Assay for candida species
KR101590175B1 (ko) * 2009-09-24 2016-01-29 주식회사 씨젠 반복적 엑소핵산 절단 반응에 의한 타겟 핵산서열의 검출
US9914963B2 (en) 2009-09-28 2018-03-13 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
RU2577726C2 (ru) 2009-10-21 2016-03-20 Дженентек, Инк. Генетические полиморфизмы при возрастной дегенерации желтого пятна
CN102639712A (zh) * 2009-10-23 2012-08-15 卢米耐克斯公司 用于提高反应特异性的具有非标准碱基的扩增引物
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
JP6147502B2 (ja) 2009-10-27 2017-06-14 スウィフト バイオサイエンシーズ， インコーポレイテッド ポリヌクレオチドプライマー及びプローブ
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
WO2011053852A1 (en) 2009-10-30 2011-05-05 The Regents Of The University Of California Gna11 mutations in melanoma
US20120245041A1 (en) 2009-11-04 2012-09-27 Sydney Brenner Base-by-base mutation screening
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
BR112012011280A2 (pt) 2009-11-13 2019-09-24 Beckman Coulter Inc sistemas e metodos para detectar a presenca de um status biologico usando grafico
CN102713919B (zh) * 2009-11-13 2016-07-06 贝克曼考尔特公司 用于使用聚类来检测生物学状态的存在的系统和方法
US20110117546A1 (en) * 2009-11-18 2011-05-19 Microfluidic Systems, Inc. Increase of signal sensitivity using dual probes in pcr reactions
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
US9133343B2 (en) 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
CN105463071A (zh) 2009-12-03 2016-04-06 奎斯特诊断投资有限公司 诊断细菌性阴道炎的方法
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
WO2011084757A1 (en) 2009-12-21 2011-07-14 University Of Southern California Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
CN102762744B (zh) 2009-12-21 2017-07-25 Seegene株式会社 利用靶信号产生引物进行的靶检测
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
US8877437B1 (en) 2009-12-23 2014-11-04 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection
WO2011085334A1 (en) 2010-01-11 2011-07-14 University Of Southern California Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
WO2011100057A2 (en) 2010-02-09 2011-08-18 Eugene Spier Methods and compositions for universal detection of nucleic acids
WO2011101744A2 (en) 2010-02-22 2011-08-25 Population Genetics Technologies Ltd. Region of interest extraction and normalization methods
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
WO2011107887A2 (en) 2010-03-02 2011-09-09 Population Genetic Technologies Ltd. Methods for replicating polynucleotides with secondary structure
WO2011118496A1 (ja) 2010-03-23 2011-09-29 和光純薬工業株式会社 クラミジア・トラコマティス検出用プライマー及びプローブ、並びにこれを用いたクラミジア・トラコマティスの検出方法
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
BR112012025593A2 (pt) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings biomarcadores em circulação para doença
DE102010003781B4 (de) 2010-04-08 2012-08-16 Aj Innuscreen Gmbh Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen
US20110250598A1 (en) 2010-04-12 2011-10-13 Ulrike Fischer Detergent free polymerases
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
WO2011130728A1 (en) 2010-04-17 2011-10-20 Bayer Healthcare Llc Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2011131774A1 (en) 2010-04-21 2011-10-27 Erik Berntorp Genetic factors associated with inhibitor development in hemophilia a
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
WO2011139371A1 (en) 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9309565B2 (en) 2010-05-14 2016-04-12 Life Technologies Corporation Karyotyping assay
US8618253B2 (en) 2010-05-25 2013-12-31 Samsung Techwin Co., Ltd. Modified RNAse H and detection of nucleic acid amplification
WO2011150227A1 (en) 2010-05-26 2011-12-01 Qiagen Gaithersburg, Inc. Quantitative helicase assay
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
WO2011150277A2 (en) 2010-05-28 2011-12-01 Life Technologies Corporation Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization
WO2011154139A2 (en) 2010-06-07 2011-12-15 Roche Diagnostics Gmbh Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
WO2011156434A2 (en) 2010-06-07 2011-12-15 Firefly Bioworks, Inc. Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
US20120035062A1 (en) 2010-06-11 2012-02-09 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
AU2011267421B2 (en) 2010-06-18 2014-04-24 F. Hoffmann-La Roche Ag DNA polymerases with increased 3'-mismatch discrimination
US8722378B2 (en) 2010-06-18 2014-05-13 Roche Molecular Systems, Inc. DNA polymerases with increased 3′-mismatch discrimination
EP2582803B1 (de) 2010-06-18 2015-02-25 Roche Diagnostics GmbH Dna polymerasen mit erhöhter unterscheidung von 3' fehlpaarungen
WO2011157438A1 (en) 2010-06-18 2011-12-22 Roche Diagnostics Gmbh Dna polymerases with increasesed 3'-mismatch discrimination
US8759062B2 (en) 2010-06-18 2014-06-24 Roche Molecular Systems, Inc. DNA polymerases with increased 3′- mismatch discrimination
CN103025870B (zh) 2010-06-18 2015-07-01 霍夫曼-拉罗奇有限公司 具有增强的3’-错配辨别力的dna聚合酶
EP2582807B1 (de) 2010-06-18 2015-03-18 Roche Diagnostics GmbH Dna polymerasen mit erhöhter unterscheidung von 3' fehlpaarungen
EP2582804B1 (de) 2010-06-18 2015-02-25 Roche Diagnostics GmbH Dna polymerasen mit erhöhter unterscheidung von 3' fehlpaarungen
WO2011161549A2 (en) 2010-06-24 2011-12-29 Population Genetics Technologies Ltd. Methods and compositions for polynucleotide library production, immortalization and region of interest extraction
EP2586443B1 (de) 2010-06-25 2016-03-16 Eisai R&D Management Co., Ltd. Antitumorwirkstoff mit verbindungen mit kinasehemmungswirkung in kombination
WO2012003412A2 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Inducible nucleic acid targets for detection of pathogens, methods and compositions thereof
EP2902506B1 (de) 2010-06-30 2016-10-26 Life Technologies Corporation Nachweis von Listerien in Lebensmittel- und Umweltproben, Verfahren und Zusammensetzungen dafür
US9650629B2 (en) 2010-07-07 2017-05-16 Roche Molecular Systems, Inc. Clonal pre-amplification in emulsion
WO2012016936A1 (de) 2010-07-31 2012-02-09 Aj Innuscreen Gmbh Nachweis spezifischer nukleinsäuresequenzen mittels fluoreszenz - quenching
DE102010033107A1 (de) 2010-08-02 2012-02-02 Aj Innuscreen Gmbh Nachweis spezifischer Nukleinsäuresequenzen mittels Fluoreszenzlöschung
WO2012018964A1 (en) 2010-08-03 2012-02-09 Life Technologies Corporation Detection of salmonella enterica subspecies enterica serovar enteritidis in food and environmental samples, methods and compositions thereof
CN106198656B (zh) 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
US8557532B2 (en) 2010-08-30 2013-10-15 The University Of Utah Research Foundation Diagnosis and treatment of drug-resistant Ewing'S sarcoma
EP2611932A2 (de) 2010-08-30 2013-07-10 Gen-Probe Incorporated Zusammensetzungen, verfahren und reaktionsmischungen für den nachweis von xenotropic murine leukemia virus-related virus (xmrv)
WO2012033848A1 (en) 2010-09-07 2012-03-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
EP2614159B1 (de) 2010-09-10 2017-11-08 Bio-Rad Laboratories, Inc. Grössenauswahl von dna zur chromatinanalyse
US9051606B2 (en) 2010-09-10 2015-06-09 Qiagen Gaithersburg, Inc. Methods and compositions for nucleic acid detection
CN103119175B (zh) * 2010-09-20 2017-11-28 Seegene株式会社 在固相利用单一标记固定化探针及外切核酸活性的靶核酸序列检测
DK2623613T3 (en) 2010-09-21 2016-10-03 Population Genetics Tech Ltd Increasing the reliability of the allele-indications by molecular counting
EP2937423A1 (de) 2010-09-21 2015-10-28 Life Technologies Corporation Se33-mutationen mit auswirkung auf die genotypkonkordanz
WO2012038049A2 (en) 2010-09-22 2012-03-29 Roche Diagnostics Gmbh Amplification of distant nucleic acid targets using engineered primers
WO2012040619A2 (en) 2010-09-24 2012-03-29 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
EP3572528A1 (de) 2010-09-24 2019-11-27 The Board of Trustees of the Leland Stanford Junior University Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer
WO2012045668A1 (en) 2010-10-04 2012-04-12 Roche Diagnostics Gmbh Method for cell lysis in a rt-pcr reaction buffer
CA2810316A1 (en) 2010-10-04 2012-04-12 F. Hoffmann-La Roche Ag Method for cell lysis and pcr within the same reaction vessel
JP6174999B2 (ja) 2010-10-04 2017-08-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｐｃｒ反応緩衝液中での細胞溶解のための方法
DK2625295T3 (da) 2010-10-08 2019-06-11 Harvard College High-throughput-immunsekvensering
DK2625320T3 (da) 2010-10-08 2019-07-01 Harvard College High-throughput enkeltcellestregkodning
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
AR083497A1 (es) * 2010-10-21 2013-02-27 Riken Kit para detectar el virus de la leucemia bovina (blv), y uso del mismo
KR20120042100A (ko) 2010-10-22 2012-05-03 주식회사 씨젠 이중표지 고정화 프로브를 이용한 고상에서의 타겟 핵산서열 검출
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN103384724B (zh) 2010-10-22 2017-11-17 T2生物系统公司 用于检测分析物的核磁共振系统和方法
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
GB201017978D0 (en) 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
DE102010052524A1 (de) 2010-11-22 2012-05-24 Aj Innuscreen Gmbh Verfahren zum qualitativen und quantitativen Nachweis von spezifischen Nukleinsäuresequenzen in Echtzeit
WO2012073053A1 (en) 2010-11-30 2012-06-07 Diagon Kft. Procedure for nucleic acid-based molecular diagnostic determination of bacterial germ counts and kit for this purpose
US9169514B2 (en) 2010-12-03 2015-10-27 Brandeis University Detecting nucleic acid variations within populations of genomes
WO2012087135A1 (en) 2010-12-22 2012-06-28 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Genetic markers specific for clostridium difficile ribotypes 027 (nap01/b1; rt 027) and 078 (nap7/8; rt 078) and their use
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
ES2860945T3 (es) 2010-12-27 2021-10-05 Abbott Molecular Inc Cuantificación de muestras de títulos altos por PCR digital
US9487838B2 (en) 2010-12-28 2016-11-08 Qiagen Hamburg Gmbh Oligonucleotide probe for the detection of adenovirus
US9594870B2 (en) 2010-12-29 2017-03-14 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
EP2658999B1 (de) 2010-12-30 2019-03-13 Life Technologies Corporation Modelle zur analyse von daten aus sequenzierung-mit-synthese-operationen
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092461A2 (en) 2010-12-30 2012-07-05 Pioneer Hi-Bred International, Inc. Methods of identifying aphid resistant soybeans
US10241075B2 (en) 2010-12-30 2019-03-26 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
MX2017015093A (es) 2011-01-11 2023-03-10 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
EP3733870A3 (de) 2011-01-14 2021-01-27 Life Technologies Corporation Verfahren zur identifikation und quantifizierung von mirnas
EP3567121B1 (de) 2011-01-17 2023-08-30 Life Technologies Corporation Arbeitsablauf zum nachweis von liganden mit nukleinsäuren
EP2670865A4 (de) 2011-01-31 2014-09-10 Primeradx Inc Verfahren für nukleinsäurequantifizierung und -nachweis durch anomale migration
US9365897B2 (en) 2011-02-08 2016-06-14 Illumina, Inc. Selective enrichment of nucleic acids
WO2012107537A1 (en) 2011-02-09 2012-08-16 Riboxx Gmbh Method for the detection of polynucleotide sequences
EP2675897B1 (de) 2011-02-15 2016-05-11 Roche Diagnostics GmbH Dna-polymerasen mit erhöhter unterscheidung von 3'-diskrepanz
US20120208193A1 (en) 2011-02-15 2012-08-16 Bio-Rad Laboratories, Inc. Detecting methylation in a subpopulation of genomic dna
WO2012112883A1 (en) 2011-02-18 2012-08-23 Yale University The kras-variant and endometriosis
EP2683833B1 (de) 2011-03-10 2018-09-26 Gen-Probe Incorporated Verfahren zur auswahl und optimierung von oligonukleotid-tagsequenzen
US20140065615A1 (en) 2011-03-21 2014-03-06 Yale University The KRAS Variant and Tumor Biology
WO2012134195A2 (en) 2011-03-29 2012-10-04 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent cleavage
EP2508625A1 (de) 2011-04-05 2012-10-10 Université de Franche-Comté Echtzeit-Duplex-PCR für zur simultanen HPV16- und HPV18-Viruslastquantifizierung
EP2694675B1 (de) 2011-04-08 2018-01-24 Life Technologies Corporation Phasenschützende reagenzflussordnungen für die verwendung zur sequenzierung durch synthese
EP2697372B1 (de) 2011-04-11 2015-12-16 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
CA2828946C (en) 2011-04-18 2016-06-21 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
DE102012008375A1 (de) 2011-04-27 2012-10-31 Genovoxx Gmbh Methoden und Komponenten zur Detektion von Nukleinsäureketten
WO2012149438A1 (en) 2011-04-28 2012-11-01 Life Technologies Corporation Methods and compositions for multiplex pcr
US10172305B2 (en) 2011-04-29 2019-01-08 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
EP3378954B1 (de) 2011-04-29 2021-02-17 Sequenom, Inc. Quantifizierung einer minderheitsvariante einer nukleinsäure
AU2012250879B2 (en) 2011-05-02 2017-06-08 Nutech Ventures Plants with useful traits and related methods
US9850524B2 (en) 2011-05-04 2017-12-26 Seegene, Inc. Detection of target nucleic acid sequences by PO cleavage and hybridization
WO2012150749A1 (en) * 2011-05-04 2012-11-08 Seegene, Inc. Detection of target nucleic acid sequences by po cleavage and hybridization
WO2012153153A1 (en) 2011-05-11 2012-11-15 Diagon Kft. Procedure for rapid determination of viruses using nucleic acid-based molecular diagnostics, and a kit for this purpose
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
EP4249603A3 (de) 2011-06-08 2024-01-03 Life Technologies Corporation Design und entwicklung neuartiger reinigungsmittel zur verwendung in pcr-systemen
EP2721173A1 (de) 2011-06-14 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur bestimmung des expressionsniveaus eines bestimmten gens mit korrektur von rt-qpcr-daten für signale aus der genomischen dna
WO2012178210A1 (en) 2011-06-23 2012-12-27 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
US9487824B2 (en) 2011-06-28 2016-11-08 Igor Kutyavin Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
DE102011078342A1 (de) 2011-06-29 2013-01-03 Aj Innuscreen Gmbh Rehybridisierendes Sondensystem zur qualitativen und quantitativen Messung von spezifischen Nukleinsäuren in Echtzeit
ES2553400T3 (es) 2011-07-28 2015-12-09 F. Hoffmann-La Roche Ag ADN polimerasas con actividad mejorada
US9758837B2 (en) 2011-08-02 2017-09-12 The United States Of America, As Represented By The Secretary Of Agriculture Sensitive and rapid method for Candidatus Liberibacter species detection
US8778843B1 (en) 2011-08-03 2014-07-15 Fry Laboratories, L.L.C. Semi-pan-protozoal by quantitative PCR
US8592156B2 (en) 2011-08-08 2013-11-26 Roche Molecular Systems, Inc. Predicting response to anti-CD20 therapy in DLBCL patients
EP3624124B1 (de) 2011-08-18 2023-11-22 Life Technologies Corporation Systeme zur herstellung von basenzuordnungen in einer nukleinsäuresequenzierung
AU2012300985A1 (en) 2011-08-31 2014-02-13 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
WO2013033611A1 (en) 2011-08-31 2013-03-07 Monsanto Technology Llc Methods and compositions for watermelon firmness
JP2014526901A (ja) 2011-08-31 2014-10-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗血管新生療法に伴う高血圧のリスクを予測する方法
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
CA2849023C (en) 2011-09-15 2022-07-19 David A. Shafer Probe:antiprobe compositions for high specificity dna or rna detection
WO2013038010A2 (en) 2011-09-16 2013-03-21 Lexogen Gmbh Nucleic acid transcription method
MD4589C1 (ro) 2011-09-16 2019-03-31 Gilead Pharmasset Llc Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C
EP2570487A1 (de) 2011-09-16 2013-03-20 Lexogen GmbH Verfahren zur Nukleinsäuretranskription
MX2014002990A (es) 2011-09-19 2014-05-21 Genentech Inc Tratamientos combinados que comprenden antagonistas de c-met y antagonistas de b-raf.
WO2013041577A1 (en) 2011-09-20 2013-03-28 Vib Vzw Methods for the diagnosis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
EP2758547B1 (de) 2011-09-21 2015-09-16 Gen-Probe Incorporated Verfahren zur amplifikation von nukleinsäuren unter verwendung von tag-vermittelter verschiebung
CN107267615A (zh) 2011-09-23 2017-10-20 霍夫曼-拉罗奇有限公司 G形夹用于改进的等位基因特异性pcr的用途
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
EP2761023B1 (de) 2011-09-28 2018-03-07 Qualicon Diagnostics LLC Sequenzen und ihre verwendung für den nachweis und die charakterisierung von stec-bakterien
WO2013049613A1 (en) * 2011-09-29 2013-04-04 Luminex Corporation Hydrolysis probes
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
CA2853088C (en) 2011-10-21 2018-03-13 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
CA2888915A1 (en) 2011-10-28 2013-05-02 The Regents Of The University Of California Flt3 mutations associated with drug resistance in aml patients having activating mutations in flt3
CN108103145A (zh) 2011-10-31 2018-06-01 荣研化学株式会社 靶核酸的检测方法
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
AU2012335983B2 (en) 2011-11-09 2018-05-31 Qualicon Diagnostics, Llc Sequences and their use for detection of Salmonella
AU2012342682A1 (en) 2011-11-23 2014-05-22 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
EP2785860B1 (de) 2011-11-29 2015-06-03 Life Technologies Corporation Verfahren und zusammensetzungen für multiplex-pcr
WO2013081864A1 (en) 2011-11-29 2013-06-06 Life Technologies Corporation Methods and compositions for multiplex pcr
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9260714B2 (en) 2011-12-02 2016-02-16 Roche Molecular Systems, Inc. Suppression of non-specific amplification with high-homology oligonucleotides
EP2788481B1 (de) 2011-12-08 2018-03-07 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
WO2013083262A1 (en) 2011-12-08 2013-06-13 Roche Diagnostics Gmbh Dna polymerases with improved activity
EP2788479B1 (de) 2011-12-08 2016-02-10 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
EP3450572A1 (de) 2011-12-23 2019-03-06 bioMérieux Nachweis von meca-varianten-stämmen von methicillin-resistentem staphylococcus aureus
US9284574B2 (en) 2011-12-29 2016-03-15 Pioneer Hi Bred International Inc Rag-based selection methods for improving aphid resistance in soybeans
EP2872523B1 (de) 2011-12-30 2018-01-17 Abbott Molecular Inc. Mikroorganismus-nukleinsäurereinigung von wirtsproben
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
US9515676B2 (en) 2012-01-31 2016-12-06 Life Technologies Corporation Methods and computer program products for compression of sequencing data
US9864846B2 (en) 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
KR20130101952A (ko) 2012-02-02 2013-09-16 주식회사 씨젠 Ｐｔｏ 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출
EP4361606A2 (de) 2012-02-03 2024-05-01 California Institute of Technology Signalkodierung und -dekodierung in multiplexierten biochemischen assays
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
WO2013124743A1 (en) 2012-02-22 2013-08-29 Population Genetics Technologies Ltd. Compositions and methods for intramolecular nucleic acid rearrangement ii
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
EP2820157B1 (de) 2012-03-02 2019-05-01 Winthrop-University Hospital Verfahren zur verwendung von sondenbasierter pcr-detektion zum messen der konzentration von dna aus zirkulierenden entmethylierten beta-zellen als massstab für beta-zell-verlust bei diabetes
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
AU2013228226B2 (en) 2012-03-05 2016-06-02 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by PTO cleavage and extension assay
WO2013139860A1 (en) 2012-03-21 2013-09-26 Roche Diagnostics Gmbh Methods for assessing rna quality
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
CA2869313A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Gene expression panel for breast cancer prognosis
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
US20150111769A1 (en) 2012-04-17 2015-04-23 Yamaguchi University Method for assessing endometrial cancer susceptibility
EP2653558B1 (de) 2012-04-18 2015-10-07 Roche Diagniostics GmbH Verfahren zur Erkennung von Nukleinsäuretargets mithilfe eines statistischen Klassifizierers
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
SG11201407107VA (en) 2012-05-08 2014-11-27 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
WO2013188839A1 (en) 2012-06-14 2013-12-19 Life Technologies Corporation Novel compositions, methods and kits for real time polymerase chain reaction (pcr)
US9347105B2 (en) 2012-06-15 2016-05-24 Pioneer Hi Bred International Inc Genetic loci associated with resistance of soybean to cyst nematode and methods of use
WO2013192100A1 (en) 2012-06-18 2013-12-27 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods and compositions for detecting jc virus
CN110777195A (zh) 2012-07-13 2020-02-11 生命技术公司 采用一组snp的人身份识别
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014014991A2 (en) 2012-07-19 2014-01-23 President And Fellows Of Harvard College Methods of storing information using nucleic acids
EP3901243A1 (de) 2012-08-03 2021-10-27 California Institute of Technology Multiplexing und quantifizierung in pcr mit reduzierter hardware und reduzierten anforderungen
US10993418B2 (en) 2012-08-13 2021-05-04 Life Genetics Lab, Llc Method for measuring tumor burden in patient derived xenograft (PDX) mice
US9957557B2 (en) 2012-08-13 2018-05-01 Life Genetics Lab, Llc Development of a highly sensitive quantification system for assessing DNA degradation and quality in forensic samples
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
ES2761920T3 (es) 2012-08-30 2020-05-21 Gen Probe Inc Amplificación de ácido nucleico multifásica
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
EP2902499B1 (de) 2012-09-28 2018-09-12 BNA Inc. Bna-klemmverfahren
AU2013327423B2 (en) 2012-10-01 2017-06-22 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
EP2722399A1 (de) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Verfahren zur Vermeidung von Produkten mit hohem Molekulargewicht während einer Amplifikation
ES2640570T3 (es) 2012-10-18 2017-11-03 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de VHC
EP2722397B1 (de) 2012-10-18 2017-12-13 F. Hoffmann-La Roche AG Test mit zwei Sonden zur Erkennung von heterogenen Amplikonpopulationen
WO2014068072A1 (en) 2012-10-31 2014-05-08 Institut Gustave-Roussy Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
EP3260558B1 (de) 2012-11-02 2020-05-13 Life Technologies Corporation Neuartige zusammensetzungen und verfahren zur verstärkung der pcr-spezifität
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
EP2932421A1 (de) 2012-12-12 2015-10-21 The Broad Institute, Inc. Verfahren, systeme und vorrichtung zur identifizierung von zielsequenzen für cas-enzyme oder crispr-cas-systeme für zielsequenzen und ergebnisübermittlung
EP2931899A1 (de) 2012-12-12 2015-10-21 The Broad Institute, Inc. Funktionale genomik unter verwendung von crispr-cas systemen, zusammensetzungen, verfahren, knockout-bibliotheken und anwendungen davon
JP6552965B2 (ja) 2012-12-12 2019-07-31 ザ・ブロード・インスティテュート・インコーポレイテッド 配列操作のための改善された系、方法および酵素組成物のエンジニアリングおよび最適化
ES2576128T3 (es) 2012-12-12 2016-07-05 The Broad Institute, Inc. Modificación por tecnología genética y optimización de sistemas, métodos y composiciones para la manipulación de secuencias con dominios funcionales
ES2701749T3 (es) 2012-12-12 2019-02-25 Broad Inst Inc Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
ES2883590T3 (es) 2012-12-12 2021-12-09 Broad Inst Inc Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
WO2014093714A1 (en) 2012-12-14 2014-06-19 Bio-Rad Laboratories, Inc. Methods and compositions for using oils for analysis and detection of molecules
CN104755463A (zh) 2012-12-21 2015-07-01 卫材R&D管理有限公司 非晶态形式的喹啉衍生物及其生产方法
WO2014104818A1 (en) 2012-12-27 2014-07-03 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent non-hybridization assay
NZ625087A (en) 2013-01-31 2017-05-26 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US9850515B2 (en) 2013-02-08 2017-12-26 Bio-Rad Laboratories, Inc. Affinity-based partition assay for detection of target molecules
US10000819B2 (en) 2013-02-21 2018-06-19 Qualicon Diagnostics Llc Sequences and their use for detection and characterization of E. coli O157:H7
EP2770065B1 (de) 2013-02-25 2017-12-13 Seegene, Inc. Detektion einer Nukleotidvariation auf Nukleinsäurezielsequenz
EP2964785B8 (de) 2013-03-04 2020-10-21 Fry Laboratories LLC Verfahren und kit zur charakterisierung von mikroorganismen
EP2964781B1 (de) 2013-03-08 2018-01-10 Roche Diagnostics GmbH Bluttest auf egfr-mutationen
US20140287417A1 (en) 2013-03-08 2014-09-25 Roche Molecular Systems, Inc. EGFR Blood Monitoring
EP3640347A3 (de) 2013-03-12 2020-07-29 Life Technologies Corporation Verfahren und materialien für universelle reporterbasierte genotypisierung
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
EP2971115B1 (de) 2013-03-13 2022-07-27 Seegene, Inc. Quantifizierung von zielnukleinsäuren unter verwendung von schmelzspitzenwertanalyse
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US9828629B2 (en) 2013-03-15 2017-11-28 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
EP2971104A2 (de) 2013-03-15 2016-01-20 Abbott Molecular Inc. Verfahren zur amplifikation und analyse von rna-fusionsgenvarianten, verfahren zur unterscheidung davon sowie primer, sonden und kits
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
KR20210037750A (ko) 2013-03-15 2021-04-06 아벨리노 랩 유에스에이, 인크. 대립유전자 검출을 위한 게놈 dna 주형의 개선된 단리 방법
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
EP3312295A1 (de) 2013-03-19 2018-04-25 Directed Genomics, LLC Anreicherung von zielsequenzen
WO2014160797A1 (en) 2013-03-26 2014-10-02 Genetag Technology, Inc. Dual probe:antiprobe compositions for dna and rna detection
CN112870368A (zh) 2013-03-27 2021-06-01 西达-赛奈医疗中心 通过抑制tl1a的功能和相关信号传导途径来减轻并逆转纤维化和炎症
CN105247071B (zh) * 2013-04-01 2018-11-23 基因特力株式会社 使用等位基因特异的反应性引物的核酸扩增方法
WO2014172434A1 (en) 2013-04-16 2014-10-23 The Johns Hopkins University Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
US9822418B2 (en) 2013-04-22 2017-11-21 Icahn School Of Medicine At Mount Sinai Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis
EP2994559B1 (de) 2013-05-09 2020-07-08 Bio-rad Laboratories, Inc. Magnetischer immundigitaler pcr-test
MX368099B (es) 2013-05-14 2019-09-19 Eisai R&D Man Co Ltd Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
CN105492611A (zh) 2013-06-17 2016-04-13 布罗德研究所有限公司 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
CA2915834A1 (en) 2013-06-17 2014-12-24 Massachusetts Institute Of Technology Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
RU2716420C2 (ru) 2013-06-17 2020-03-11 Те Брод Инститьют Инк. Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
CN105793425B (zh) 2013-06-17 2021-10-26 布罗德研究所有限公司 使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
RU2725502C2 (ru) 2013-06-17 2020-07-02 Те Брод Инститьют Инк. Доставка, конструирование и оптимизация систем, способы и композиции для целенаправленного воздействия и моделирования заболеваний и нарушений постмитотических клеток
EP3957743A1 (de) * 2013-06-19 2022-02-23 Luminex Corporation Multiplexierter echtzeithydrolysesondentest
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
DE102013213279B4 (de) 2013-07-06 2024-03-28 Ist Innuscreen Gmbh Universelles Verfahren zur Detektion von diversen Analyten in Form von Nukleinsäuresequenzen
US20160244816A1 (en) 2013-07-15 2016-08-25 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent immobilized oligonucleotide hybridization
EP3022295A4 (de) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signatur des tl1a (tnfsf15)-signalweges
US10392670B2 (en) 2013-07-25 2019-08-27 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
US9926597B2 (en) 2013-07-26 2018-03-27 Life Technologies Corporation Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same
US10093978B2 (en) 2013-08-12 2018-10-09 Genentech, Inc. Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
CA2920636A1 (en) 2013-08-20 2015-02-23 E. I. Du Pont De Nemours And Company Sequences and their use for detection of salmonella enteritidis and/or salmonella typhimurium
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
US10410739B2 (en) 2013-10-04 2019-09-10 Life Technologies Corporation Methods and systems for modeling phasing effects in sequencing using termination chemistry
AU2014331828B2 (en) 2013-10-09 2020-05-14 Fluoresentric, Inc. Multiplex probes
JP6524073B2 (ja) 2013-10-17 2019-06-05 センター フォー アディクション アンド メンタル ヘルス 抗精神病薬誘導体重増加に関連する遺伝子マーカーおよびその使用のための方法
US20160230231A1 (en) 2013-10-18 2016-08-11 Institut De Cardiologie De Montreal Genotyping tests and methods for evaluating plasma creatine kinase levels
US11447814B2 (en) 2013-10-18 2022-09-20 Seegene, Inc. Detection of target nucleic acid sequence on solid phase by PTO cleavage and extension using HCTO assay
EP3058091B1 (de) 2013-10-18 2020-03-25 The Broad Institute, Inc. Räumliche und zelluläre kartographie von biomolekülen in situ durch hochdurchsatz-sequenzierung
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US20160272997A1 (en) 2013-10-25 2016-09-22 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
CN106458885B (zh) 2013-10-25 2019-12-10 生命技术公司 用于聚合酶链式反应系统的新颖化合物及其应用
KR20230007558A (ko) 2013-11-15 2023-01-12 아벨리노 랩 유에스에이, 인크. 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법
ES2703792T3 (es) 2013-11-22 2019-03-12 Orion Diagnostica Oy Detección de ácidos nucleicos mediante amplificación basada en invasión de hebra
NZ728726A (en) 2013-11-27 2018-09-28 Seminis Vegetable Seeds Inc Disease resistance loci in onion
US10927408B2 (en) 2013-12-02 2021-02-23 Personal Genome Diagnostics, Inc. Method for evaluating minority variants in a sample
ES2851384T3 (es) 2013-12-04 2021-09-06 Newleaf Symbiotics Inc Composiciones y métodos para mejorar la producción de lechuga
WO2015085230A1 (en) 2013-12-06 2015-06-11 Bio-Rad Laboratories, Inc. Fusion polymerases
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
MX2016007327A (es) 2013-12-12 2017-03-06 Broad Inst Inc Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para dirigirlos a trastornos y enfermedades usando componentes para suministro de particulas.
US20150176060A1 (en) 2013-12-20 2015-06-25 Roche Molecular Systems, Inc. Method For Coding Of Multiple PCR Reactions For Assay Recognition
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
US9243289B2 (en) * 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
RU2019107011A (ru) 2014-01-24 2019-04-08 Лэм Терапьютикс, Инк. Композиции апилимода и способы их применения
TW202239429A (zh) 2014-02-08 2022-10-16 美商建南德克公司 治療阿茲海默症之方法
CN105531408B (zh) 2014-02-13 2019-09-10 生物辐射实验室股份有限公司 染色体构象划分产物捕获
CN106231893B (zh) 2014-02-21 2019-10-18 先正达参股股份有限公司 与玉米增加的能育性相关的遗传基因座
CA2940322C (en) 2014-02-21 2021-05-18 President And Fellows Of Harvard College De novo design of allosteric proteins
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
WO2015127557A1 (en) 2014-02-28 2015-09-03 Centre For Addiction And Mental Health Compositions and methods for the treatment and prevention of antipsychotic medication-induced weight gain
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
KR102207922B1 (ko) 2014-03-06 2021-01-26 삼성전자주식회사 반코마이신 저항성 엔테로코커스 특이적인 프라이머 세트, 그를 포함하는 조성물 및 시료 중 반코마이신 저항성 엔테로코커스 속 미생물을 검출하는 방법
EP3117011B1 (de) 2014-03-13 2020-05-06 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
EP3119204B1 (de) 2014-03-17 2020-02-26 Newleaf Symbiotics, Inc. Zusammensetzungen und verfahren zur verbesserung der tomatenproduktion
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
EP3125907A4 (de) 2014-04-01 2017-11-29 Cornell University Verwendung von doppelsträngiger dna in exosomen: neuartiger biomarker zur krebsdetektion
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3792366A1 (de) 2014-04-04 2021-03-17 Affymetrix, Inc. Verbesserte zusammensetzungen und verfahren für molekularinversionsprobenassays
EP3132059B1 (de) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen
US20160053302A1 (en) 2014-04-22 2016-02-25 Roche Molecular Systems, Inc. Method for visual identification of pcr solutions for accurate reaction setup
AU2015257654A1 (en) 2014-05-09 2016-11-10 Lifecodexx Ag Detection of DNA that originates from a specific cell-type and related methods
EP2942401A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Nachweis von aus einem spezifischen Zelltyp stammender DNA
EP2942400A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex-Nachweis von DNA, die aus einem spezifischen Zelltyp herrührt
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3146076A4 (de) 2014-05-22 2018-05-09 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
CA2949959A1 (en) 2014-05-22 2015-11-26 Northwestern University Gene expression profiles associated with sub-clinical kidney transplant rejection
WO2015185564A1 (en) * 2014-06-02 2015-12-10 Base4 Innovation Ltd Nucleotide polymorphism detection method
WO2015200855A1 (en) 2014-06-26 2015-12-30 University Of Florida Research Foundation, Inc. Rapid detection of infectious agents
CN107209188A (zh) 2014-06-27 2017-09-26 雅培制药有限公司 用于检测人Pegivirus 2 (HPgV‑2)的组合物和方法
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
AU2015287576A1 (en) 2014-07-10 2017-02-02 Fluoresentric, Inc. DNA amplification technology
WO2016014493A1 (en) 2014-07-22 2016-01-28 Bio-Rad Laboratories, Inc. Buffers for use with polymerases
RU2697502C2 (ru) 2014-07-24 2019-08-14 Эбботт Молекьюлар Инк. Композиции и способы обнаружения и анализа микобактерии туберкулеза (mycobacterium tuberculosis)
WO2016016157A1 (en) 2014-07-30 2016-02-04 F. Hoffmann-La Roche Ag Genetic markers for predicting responsiveness to therapy with hdl-raising or hdl mimicking agent
WO2016028682A1 (en) 2014-08-17 2016-02-25 The Broad Institute Inc. Genome editing using cas9 nickases
WO2016028712A1 (en) 2014-08-18 2016-02-25 The Texas A&M University System Beta lactamase as biomarker for the specific detection of tuberculosis-complex bacteria
JO3783B1 (ar) 2014-08-28 2021-01-31 Eisai R&D Man Co Ltd مشتق كوينولين عالي النقاء وطريقة لإنتاجه
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
SG11201702060VA (en) 2014-09-15 2017-04-27 Abvitro Inc High-throughput nucleotide library sequencing
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス， インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
US10370673B2 (en) 2014-09-26 2019-08-06 Purecircle Sdn Bhd Single nucleotide polymorphism (SNP) markers for stevia
AU2015327756B2 (en) 2014-09-30 2018-01-04 Genetic Technologies Limited Methods for assessing risk of developing breast cancer
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
EP3005862A1 (de) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melonenpflanzen mit verbesserter krankheitstoleranz
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
EP3207156A1 (de) 2014-10-13 2017-08-23 Life Technologies Corporation Verfahren, kits und zusammensetzungen zur bestimmung der genkopienzahl
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
WO2016069886A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corporation Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
KR102287811B1 (ko) 2014-10-31 2021-08-09 삼성전자주식회사 2개 표면을 결합시키는 방법 및 그에 의하여 제조된 구조체, 및 상기 구조체를 포함하는 미세유동 장치
US10206910B2 (en) 2014-11-07 2019-02-19 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Ｉｌ－３３媒介性障害のための治療及び診断方法
EP3218467A4 (de) 2014-11-13 2018-04-11 The Board of Trustees of the University of Illinois Biologisch manipulierte hyperfunktionale »super -helikasen
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
WO2016093838A1 (en) 2014-12-11 2016-06-16 New England Biolabs, Inc. Enrichment of target sequences
EP3985115A1 (de) 2014-12-12 2022-04-20 The Broad Institute, Inc. Geschützte guide-rnas (pgrnas)
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
WO2016106244A1 (en) 2014-12-24 2016-06-30 The Broad Institute Inc. Crispr having or associated with destabilization domains
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
US10337072B2 (en) 2015-01-08 2019-07-02 The Board Of Trustees Of The University Of Illinois Copy number detection and methods
EP3250588A1 (de) 2015-01-29 2017-12-06 Board of Trustees of Michigan State University Kryptische polypeptide und verwendungen davon
US10421993B2 (en) 2015-02-11 2019-09-24 Paragon Genomics, Inc. Methods and compositions for reducing non-specific amplification products
US10641772B2 (en) 2015-02-20 2020-05-05 Takara Bio Usa, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
CA2978226A1 (en) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CN105936930A (zh) 2015-03-04 2016-09-14 松下知识产权经营株式会社 Dna检测方法和dna检测装置
CN105969655A (zh) 2015-03-10 2016-09-28 松下知识产权经营株式会社 多个核酸靶标的分析方法
CN113846144B (zh) 2015-03-17 2023-09-26 生物辐射实验室股份有限公司 检测基因组编辑
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9957393B2 (en) 2015-03-30 2018-05-01 Enzo Biochem, Inc. Monoazo dyes with cyclic amine as fluorescence quenchers
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2016168174A1 (en) 2015-04-13 2016-10-20 The Translational Genomics Research Institute Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
BR112017023275B1 (pt) 2015-04-28 2023-11-21 Monsanto Technology Llc Métodos para selecionar uma planta ou semente de milho braquítica
UA126326C2 (uk) 2015-04-30 2022-09-21 Монсанто Текнолоджі Елелсі Спосіб відбору рослини каноли, стійкої до кили капустяних
US10978174B2 (en) 2015-05-14 2021-04-13 Life Technologies Corporation Barcode sequences, and related systems and methods
EP3303611B1 (de) 2015-05-29 2019-10-02 Roche Diagnostics GmbH Verfahren zur inaktivierung von mikroben durch citraconsäureanhydrid
SG10201911134QA (en) 2015-06-05 2020-01-30 Grace W R & Co Adsorbent bioprocessing clarification agents and methods of making and using the same
BR122019028108B1 (pt) 2015-06-10 2023-04-11 Newleaf Symbiotics, Inc Composições de methylobacterium antifúngicas e métodos de utilização
CN107922941A (zh) 2015-06-15 2018-04-17 塞弗德公司 在自动化反应盒中DNA甲基化的整合的纯化和测量以及突变和/或mRNA表达水平的共同测量
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
FI3430134T3 (fi) 2015-06-18 2023-01-13 Uusia CRISPR-entsyymejä ja järjestelmiä
WO2016205749A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
RU2600873C1 (ru) * 2015-06-24 2016-10-27 Закрытое акционерное общество "ЕВРОГЕН" Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
CN108184327A (zh) 2015-07-14 2018-06-19 雅培分子公司 用于鉴定耐药性结核的组合物和方法
EP3124619B1 (de) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagenzien, verfahren und kit zur glaukomdiagnose über hunderassen hinweg und innerhalb von hunderassen
DK3277842T5 (da) 2015-08-17 2020-08-31 Kura Oncology Inc Fremgangsmåder til at behandle kræftpatienter med farnesyl-transferase-inhibitorer
WO2017031059A1 (en) 2015-08-18 2017-02-23 Monsanto Technology Llc Methods for producing cotton plants with enhanced drought tolerance and compositions thereof
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
CN108291257B (zh) 2015-09-24 2023-12-29 阿布维特罗有限责任公司 亲和-寡核苷酸缀合物及其用途
CN108369230B (zh) 2015-09-25 2021-09-17 阿布维特罗有限责任公司 用于对天然配对t细胞受体序列进行t细胞受体靶向鉴别的高通量方法
WO2017059132A1 (en) 2015-09-29 2017-04-06 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for bcg therapy
CA3024543A1 (en) 2015-10-22 2017-04-27 The Broad Institute, Inc. Type vi-b crispr enzymes and systems
WO2017075294A1 (en) 2015-10-28 2017-05-04 The Board Institute Inc. Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
EP3371211A4 (de) 2015-11-04 2019-08-21 Icahn School of Medicine at Mount Sinai Verfahren zur behandlung von tumoren und krebs sowie identifizierung von kandidatenpatienten für solch eine behandlung
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
IL259466B (en) 2015-11-20 2022-09-01 Seegene Inc A method for calibrating a target analyte data set
EP3387107B1 (de) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Röhrchenverschlusssystem und verfahren zur nukleinsäureamplifikation
CN108368547B (zh) 2015-12-15 2022-04-05 Seegene株式会社 与靶核酸序列有关的信号提取
US10694693B2 (en) 2015-12-18 2020-06-30 Monsanto Technology Llc Methods for producing corn plants with northern leaf blight resistance and compositions thereof
WO2017106447A1 (en) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
US20190233814A1 (en) 2015-12-18 2019-08-01 The Broad Institute, Inc. Novel crispr enzymes and systems
US10689689B2 (en) * 2015-12-28 2020-06-23 Roche Molecular Systems, Inc. Generic method for the stabilization of specific RNA
US10894985B2 (en) 2016-01-12 2021-01-19 Sitokine Limited Methods for predicting response to treatment
CA3011991A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
CA3011901A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
BR112018015155A2 (pt) 2016-01-25 2018-12-26 Bio Rad Europe Gmbh métodos para determinação da presença ou ausência de um micro-organismo em uma amostra, para testar rapidamente uma matriz alimentar e um micro-organismo alvo, e, composição.
JP7126704B2 (ja) 2016-01-28 2022-08-29 ザ ユニバーシティー オブ メルボルン 結腸直腸癌発症のリスクを評価するための方法
US10978173B2 (en) 2016-02-05 2021-04-13 Seegene, Inc. Method for reducing noise level of data set for a target analyte
CA3004914A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
EP3415636B1 (de) 2016-02-09 2020-11-25 Eiken Kagaku Kabushiki Kaisha Verfahren zum nachweis einer zielnukleinsäure und darin verwendete nukleinsäuresonde
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017153566A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Compositions and methods for detection of zika virus
WO2017161342A1 (en) 2016-03-17 2017-09-21 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through rnaset2
AU2017248219B2 (en) 2016-04-06 2023-09-07 Life Technologies Corporation Compositions, methods, and kits for synthesis and detection of nucleic acids
EP4151751A1 (de) 2016-04-14 2023-03-22 T2 Biosystems, Inc. Verfahren und systeme zur amplifikation in komplexen proben
KR102424476B1 (ko) 2016-04-19 2022-07-25 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
AU2017253107B2 (en) 2016-04-19 2023-07-20 Massachusetts Institute Of Technology CPF1 complexes with reduced indel activity
CA3026110A1 (en) 2016-04-19 2017-11-02 The Broad Institute, Inc. Novel crispr enzymes and systems
US20190119758A1 (en) 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
US11246868B2 (en) 2016-04-26 2022-02-15 Icahn School Of Medicine At Mount Sinai Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
AU2017257978B2 (en) 2016-04-27 2022-12-22 Gen-Probe Incorporated Blood cell lysis reagent
CN109790581A (zh) 2016-04-27 2019-05-21 米拉迪克斯有限公司 Kras-变体癌症患者的基于免疫的治疗
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
MX2018013510A (es) 2016-05-12 2019-03-28 Pioneer Hi Bred Int Metodos para determinacion genotipica simultanea y combinada.
EP3458597B1 (de) 2016-05-18 2022-09-07 Roche Diagnostics GmbH Quantitative echtzeit-pcr-amplifikation unter verwendung einer elektrobenetzungsbasierten vorrichtung
EP3464617B1 (de) 2016-05-27 2021-04-07 Roche Diagnostics GmbH Zusammensetzungen und verfahren zur detektion von trichomonas vaginalis
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
WO2017210437A1 (en) 2016-06-01 2017-12-07 Life Technologies Corporation Methods and systems for designing gene panels
WO2017213458A1 (en) 2016-06-10 2017-12-14 Seegene, Inc. Methods for preparing tagging oligonucleotides
EP3472349A1 (de) 2016-06-16 2019-04-24 Life Technologies Corporation Neuartige zusammensetzungen, verfahren und kits zum mikroorganismusnachweis
EP3455357A1 (de) 2016-06-17 2019-03-20 The Broad Institute Inc. Typ-vi-crispr-orthologe und systeme
WO2017218777A1 (en) 2016-06-17 2017-12-21 California Institute Of Technology Nucleic acid reactions and related methods and compositions
CN109476695A (zh) 2016-06-27 2019-03-15 丹娜法伯癌症研究院 用于测定rna翻译速率的方法
WO2018005873A1 (en) 2016-06-29 2018-01-04 The Broad Institute Inc. Crispr-cas systems having destabilization domain
US11602752B2 (en) 2016-06-30 2023-03-14 Seegene, Inc. Apparatus for amplificating nucleic acid and fluorescence-detecting device
EP3487616B1 (de) 2016-07-21 2023-08-09 Takara Bio USA, Inc. Multi-z-bildgebung von wells von multi-well-geräten und flüssigkeitsabgabe in die wells
US10626454B2 (en) 2016-07-27 2020-04-21 SeqMatic, LLC Compositions and methods for nucleic acid amplification and analysis
ES2926513T3 (es) 2016-07-29 2022-10-26 Juno Therapeutics Inc Métodos para evaluar la presencia o ausencia de virus competente en replicación
US10443095B2 (en) 2016-08-02 2019-10-15 Roche Molecular Systems, Inc. Helper oligonucleotide for improved efficiency of amplification and detection/quantitation of nucleic acids
WO2018031874A1 (en) 2016-08-11 2018-02-15 Monsanto Technology Llc Methods and compositions for producing corn plants with resistance to late wilt
CN109689886A (zh) 2016-08-26 2019-04-26 生命技术公司 核酸提取和扩增对照及其使用方法
KR102468174B1 (ko) 2016-09-15 2022-11-17 에프. 호프만-라 로슈 아게 멀티플렉스 pcr 수행 방법
WO2018057928A1 (en) 2016-09-23 2018-03-29 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
EP3516078A1 (de) 2016-09-23 2019-07-31 Life Technologies Corporation Zusammensetzungen und verfahren zur beurteilung der immunantwort
BR112019005748A2 (pt) 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
DE102016120124B8 (de) 2016-10-21 2018-08-23 Gna Biosolutions Gmbh Verfahren zum Durchführen einer Polymerase-Kettenreaktion und Vorrichtung zum Ausführen des Verfahrens
US11124839B2 (en) 2016-11-03 2021-09-21 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
WO2018085862A2 (en) 2016-11-07 2018-05-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
JP2020503857A (ja) 2016-12-12 2020-02-06 セファイド 自動反応カートリッジにおける統合化イムノｐｃｒ及び核酸分析
EP3551332B1 (de) 2016-12-12 2024-01-10 Cepheid Integrierte reinigung und messung der dna-methylierung und ko-messung von mutationen und/oder mrna-expressionsniveaus in einer automatisierten reaktionskartusche
WO2018111872A1 (en) 2016-12-12 2018-06-21 Grail, Inc. Methods for tagging and amplifying rna template molecules for preparing sequencing libraries
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
EP3559255A1 (de) 2016-12-23 2019-10-30 Grail, Inc. Verfahren zur hocheffizienten bibliothek-herstellung unter verwendung von doppelsträngigen adaptern
KR102402712B1 (ko) 2016-12-29 2022-05-26 주식회사 씨젠 프라이머 다이머 형성을 감소시키고 증폭 효율을 증가시키는 방법
PT3565905T (pt) 2017-01-04 2022-08-02 Mgi Tech Co Ltd Sequenciação de ácidos nucleicos utilizando reagentes de afinidade
ES2874143T3 (es) 2017-01-10 2021-11-04 Paragon Genomics Inc Métodos y composiciones para reducir códigos de barras, moleculares redundantes creados en reacciones de prolongación de cebadores
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US10137121B2 (en) 2017-02-21 2018-11-27 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
EP3432883B1 (de) 2017-02-21 2021-07-28 Kura Oncology, Inc. Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
WO2018162516A1 (en) 2017-03-08 2018-09-13 Etablissement Francais Du Sang Rhd gene allele associated with a weak d phenotype and its uses
US20180265887A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil Plants With High Tolerance to Downy Mildew
TW201840856A (zh) 2017-03-29 2018-11-16 大陸商中美冠科生物技術（太倉）有限公司 測定對胃癌之西妥昔單抗（ｃｅｔｕｘｉｍａｂ）敏感性的系統及方法
US11274344B2 (en) 2017-03-30 2022-03-15 Grail, Inc. Enhanced ligation in sequencing library preparation
WO2018183897A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Higher target capture efficiency using probe extension
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
US11572591B2 (en) 2017-04-26 2023-02-07 The Translational Genomics Research Institute Methods and assays for subtyping Staphylococcus aureus clonal complex 8 strains
CN108823287B (zh) 2017-04-28 2019-04-12 厦门大学 一种检测靶核酸序列的方法
EP3628056A4 (de) 2017-04-28 2021-03-03 Avellino Lab USA, Inc. Verfahren zum nachweis von allelen im zusammenhang mit keratokonus
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
CN111148849A (zh) 2017-05-26 2020-05-12 阿布维托有限责任公司 高通量多核苷酸文库测序和转录组分析
JP7136816B2 (ja) 2017-06-23 2022-09-13 インスクリプタ， インコーポレイテッド 核酸誘導型ヌクレアーゼ
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
TWI829642B (zh) 2017-07-24 2024-01-21 美商寬騰矽公司 高強度經標記之反應物組合物及用於定序之方法
BR112020002591A2 (pt) 2017-08-07 2020-07-28 Kura Oncology, Inc. método para o tratamento de câncer
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2019045532A2 (en) 2017-08-31 2019-03-07 Seegene, Inc. EVALUATION OF COMPONENT PERFORMANCE USING A PAIR OF DIMER FORMER PRIMERS
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
US11028439B2 (en) 2017-09-27 2021-06-08 Abbott Molecular Inc. Assay for detecting hepatitis B virus (HBV)
US20190091229A1 (en) 2017-09-27 2019-03-28 Lam Therapeutics, Inc. Therapeutic methods relating to hsp90 inhibitors
US11851650B2 (en) 2017-09-28 2023-12-26 Grail, Llc Enrichment of short nucleic acid fragments in sequencing library preparation
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
EP3628059B1 (de) 2017-10-03 2023-04-12 Abbott Molecular Inc. Test zum nachweis des humanen immunschwächevirus (hiv)
US11021763B2 (en) 2017-10-03 2021-06-01 Abbott Molecular Inc. Assay for detecting hepatitis C virus (HCV)
WO2019084055A1 (en) 2017-10-23 2019-05-02 Massachusetts Institute Of Technology CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS
US20200340041A1 (en) 2017-11-13 2020-10-29 Life Technologies Corporation Novel compositions, methods and kits for urinary tract microorganism detection
US11332736B2 (en) 2017-12-07 2022-05-17 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
WO2019118652A1 (en) 2017-12-12 2019-06-20 Essenlix Corporation Sample manipulation and assay with rapid temperature change
US11414656B2 (en) 2017-12-15 2022-08-16 Grail, Inc. Methods for enriching for duplex reads in sequencing and error correction
WO2019126803A1 (en) 2017-12-22 2019-06-27 Grail, Inc. Error removal using improved library preparation methods
US11242568B2 (en) 2017-12-29 2022-02-08 City Of Hope DNA methylation diagnostic test for breast cancer
MX2020006923A (es) 2018-01-05 2020-09-09 Seegene Inc Metodo para determinar la presencia o ausencia de m. tuberculosis, m. bovis y m. bovis bcg en una muestra.
ES2941076T3 (es) 2018-01-09 2023-05-16 Abbott Molecular Inc Ensayo para detectar Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis y Mycoplasma genitalium
EP3743728A1 (de) 2018-01-25 2020-12-02 Biogen MA Inc. Verfahren zur behandlung von spinaler muskelatrophie
US11112416B2 (en) 2018-01-30 2021-09-07 Life Technologies Corporation Instruments, devices and consumables for use in a workflow of a smart molecular analysis system
JP2021511802A (ja) 2018-01-31 2021-05-13 ジュノー セラピューティクス インコーポレイテッド 複製可能ウイルスの存在または非存在を評価するための方法および試薬
SG11202007564VA (en) 2018-02-09 2020-09-29 Genentech Inc Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
DE102018001586A1 (de) 2018-02-28 2019-10-17 Agct Gmbh Verfahren zur Detektion der Amplifikation einer Nukleinsäure mit verbesserter Spezifität
WO2019162530A1 (de) 2018-02-26 2019-08-29 Agct Gmbh Agverfahren zur amplifikation einer nukleinsäure mit verbesserter spezifität
US20190284609A1 (en) 2018-03-14 2019-09-19 Luminex Corporation Fast, multiplex amplification of nucleic acids
US20210032609A1 (en) 2018-03-21 2021-02-04 Roche Molecular Systems, Inc. Dna polymerases for efficient and effective incorporation of methylated-dntps
US11584961B2 (en) 2018-03-30 2023-02-21 Incyte Corporation Biomarkers for inflammatory skin disease
US20210040542A1 (en) 2018-04-20 2021-02-11 Seegene, Inc. Method And Apparatus For Detecting A Plurality Of Target Nucleic Acid Sequences In Sample
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
WO2020014296A1 (en) 2018-07-12 2020-01-16 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
EP3836967A4 (de) 2018-07-30 2022-06-15 ReadCoor, LLC Verfahren und systeme zur probenverarbeitung oder -analyse
EP3830302B1 (de) 2018-08-01 2022-10-05 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus
US20210317429A1 (en) 2018-08-20 2021-10-14 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
US20210324452A1 (en) 2018-09-06 2021-10-21 Hygiena, Llc Sequences and their use for detection and characterization of escherichia coli serotype o157:h7
JP2022500046A (ja) 2018-09-13 2022-01-04 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 改善されたストランド置換能力を有する変異体ｄｎａポリメラーゼ
WO2020069085A2 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
WO2020071457A1 (en) 2018-10-05 2020-04-09 Eisai R&D Management Co., Ltd. Biomarkers for a combination therapy comprising lenvatinib and everolimus
WO2020071451A1 (en) 2018-10-05 2020-04-09 Eisai R&D Management Co., Ltd. Biomarkers for a therapy comprising a sorafenib compound
US20220401460A1 (en) 2018-10-10 2022-12-22 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US20220195515A1 (en) 2018-10-29 2022-06-23 Koninklijke Nederlandse Akademie Van Wetenschappen Single cell full length RNA sequencing
EP3873469A2 (de) 2018-11-01 2021-09-08 Kura Oncology, Inc. Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
US20220017973A1 (en) 2018-12-03 2022-01-20 Roche Molecular Systems, Inc. Compositions and methods for detection of candida auris
US11268091B2 (en) 2018-12-13 2022-03-08 Dna Script Sas Direct oligonucleotide synthesis on cells and biomolecules
AU2019406778A1 (en) 2018-12-17 2021-07-22 Massachusetts Institute Of Technology Crispr-associated transposase systems and methods of use thereof
WO2020132090A1 (en) 2018-12-18 2020-06-25 Abbott Molecular Inc. Assay for detecting human papilloma virus (hpv)
CA3121923A1 (en) 2018-12-18 2020-06-25 Wenying Pan Methods for detecting disease using analysis of rna
EP3899035A1 (de) 2018-12-20 2021-10-27 F. Hoffmann-La Roche AG Nachweis einer zielnukleinsäure durch festphasenmolografie
JP2022515912A (ja) 2019-01-03 2022-02-22 ディーエヌエー スクリプト オリゴヌクレオチドセットのワンポット合成
CA3126761C (en) 2019-01-15 2023-01-10 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
JP2022518056A (ja) 2019-01-23 2022-03-11 クアンタム－エスアイ インコーポレイテッド 高強度標識されたシーケンシング用の反応組成物および方法
KR102097721B1 (ko) 2019-01-24 2020-04-06 주식회사 시선바이오머티리얼스 태그서열 snp를 이용한 단일 검출 프로브 기반 다중 표적 검출방법
EP3924739A1 (de) 2019-02-12 2021-12-22 Biogen MA Inc. Biomarker von progressiver multifokaler leukoenzephalopathie
KR20210139269A (ko) 2019-02-15 2021-11-22 인사이트 코포레이션 사이클린-의존성 키나아제 2 바이오마커 및 이들의 용도
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
EP3937780A4 (de) 2019-03-14 2022-12-07 InSilixa, Inc. Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
US20220177863A1 (en) 2019-03-18 2022-06-09 The Broad Institute, Inc. Type vii crispr proteins and systems
US11634782B2 (en) 2019-03-20 2023-04-25 Hygiena, Llc Quantification of microorganisms in samples and methods of determining quantification conditions thereof
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
JP2022527495A (ja) 2019-03-29 2022-06-02 クラ オンコロジー， インコーポレイテッド ファルネシルトランスフェラーゼ阻害剤による扁平上皮癌の治療方法
WO2020206046A1 (en) 2019-04-01 2020-10-08 The Broad Institute, Inc. Methods and compositions for cell therapy
TW202102218A (zh) 2019-04-01 2021-01-16 美商庫拉腫瘤技術股份有限公司 以法呢基(farnesyl)轉移酶抑制劑治療癌症的方法
WO2020205491A1 (en) 2019-04-05 2020-10-08 Hygiena, Llc Sequences and their use for detection and characterization of genus cronobacter
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
WO2020223583A1 (en) 2019-05-02 2020-11-05 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
WO2020221915A1 (en) 2019-05-02 2020-11-05 F. Hoffmann-La Roche Ag UTILIZATION OF dITP FOR PREFERENTIAL/SELECTIVE AMPLIFICATION OF RNA VERSUS DNA TARGETS BASED ON STRAND-SEPARATION TEMPERATURE
US20220220539A1 (en) 2019-05-07 2022-07-14 Roche Molecular Systems, Inc. Compositions and methods for detection of neisseria gonorroheae
WO2020236967A1 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Random crispr-cas deletion mutant
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2020251306A1 (en) 2019-06-14 2020-12-17 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
WO2021013972A1 (en) 2019-07-25 2021-01-28 F. Hoffmann-La Roche Ag Compositions and methods for detection of epstein barr virus (ebv)
US20220290246A1 (en) 2019-08-07 2022-09-15 Arizona Board Of Regents On Behalf Of The University Of Arizona Single nucleotide polymorphisms and uses thereof
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
WO2021028610A2 (es) 2019-08-13 2021-02-18 Universidade De Santiago De Compostela Compuestos y métodos para el tratamiento del cancer
CN116348458A (zh) 2019-08-14 2023-06-27 因赛特公司 作为cdk2抑制剂的咪唑基嘧啶基胺化合物
CN114286866A (zh) 2019-08-27 2022-04-05 豪夫迈·罗氏有限公司 用于扩增和检测包括从cccDNA转录的HBV RNA在内的乙型肝炎病毒RNA的组合物和方法
EP3569717A3 (de) 2019-08-28 2020-04-08 Boehringer Ingelheim Vetmedica GmbH Diagnostisches verfahren zur dedektion von dna und rna viren mittels polymerase kettenreaktion in einem beheizten reaktionsvolumen
WO2021041922A1 (en) 2019-08-30 2021-03-04 The Broad Institute, Inc. Crispr-associated mu transposase systems
WO2021051135A1 (en) 2019-09-12 2021-03-18 AI Therapeutics, Inc. Pikfyve inhibitors for cancer therapy
WO2021058470A1 (en) 2019-09-23 2021-04-01 Universiteit Gent Probe and method for str-genotyping
SG10202008262UA (en) 2019-09-26 2021-04-29 Seminis Vegetable Seeds Inc Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1
US11851426B2 (en) 2019-10-11 2023-12-26 Incyte Corporation Bicyclic amines as CDK2 inhibitors
EP4041918A1 (de) 2019-10-11 2022-08-17 Life Technologies Corporation Zusammensetzungen und verfahren zur beurteilung von mikrobiellen populationen
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
JP2023505327A (ja) 2019-12-09 2023-02-08 エフ．ホフマン－ラ ロシュ アーゲー ジカチオン性蛍光色素
CN115175922A (zh) 2019-12-23 2022-10-11 雅培实验室 用于检测小双核糖核酸病毒的组合物和方法
US11060141B1 (en) 2019-12-23 2021-07-13 Stilla Technologies Multiplex drop-off digital polymerase chain reaction methods
JP2023508100A (ja) 2019-12-27 2023-02-28 エフ． ホフマン－ラ ロシュ エージー． メチシリン耐性黄色ブドウ球菌を検出するための組成物および方法
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
EP4085156B1 (de) 2019-12-31 2023-10-25 F. Hoffmann-La Roche AG Quantitatives pcr-screening von induzierbaren prophagen aus bakterienisolaten
EP4056719A1 (de) 2020-02-18 2022-09-14 Life Technologies Corporation Zusammensetzungen, kits und verfahren zur detektion von viralen sequenzen
WO2021178644A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
WO2021180665A1 (en) 2020-03-09 2021-09-16 Janssen Pharmaceutica Nv Compositions and methods for quantifying integration of recombinant vector nucleic acid
WO2021180631A1 (en) 2020-03-09 2021-09-16 F. Hoffmann-La Roche Ag Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2), influenza a and influenza b
JP2023516497A (ja) 2020-03-13 2023-04-19 メドイミューン・リミテッド Ｉｌ３３にリスクアレルを有する対象を治療するための治療方法
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
US20230242971A1 (en) 2020-05-08 2023-08-03 Roche Sequencing Solutions, Inc. Removal of excess oligonucleotides from a reation mixture
US10941453B1 (en) 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
WO2021237292A1 (en) 2020-05-27 2021-12-02 Genetic Technologies Limited Methods of assessing risk of developing a severe response to coronavirus infection
KR20230007464A (ko) 2020-06-05 2023-01-12 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
JP2023536962A (ja) 2020-08-06 2023-08-30 エフ． ホフマン－ラ ロシュ アーゲー 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－２）、インフルエンザａ及びインフルエンザｂの検出のための組成物及び方法
EP4204546A1 (de) 2020-08-31 2023-07-05 City of Hope Neue zelllinien, verfahren zur herstellung natürlicher killerzellen und verwendungen davon
EP4225020A1 (de) 2020-10-12 2023-08-16 Nunhems B.V. Parthenokarpe wassermelonenpflanzen
US20240052391A1 (en) 2020-10-29 2024-02-15 Dna Script Enzymatic Synthesis of Polynucleotide Probes
MX2023005394A (es) 2020-11-09 2023-05-19 Nunhems Bv Plantas de sandia partenocarpicas.
CA3203308A1 (en) 2020-11-30 2022-06-02 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
EP4256089A1 (de) 2020-12-04 2023-10-11 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zum nachweis von malaria
JP7209980B2 (ja) 2020-12-11 2023-01-23 東洋紡株式会社 Ｄｎａポリメラーゼの５’→３’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
EP4267764A1 (de) 2020-12-22 2023-11-01 F. Hoffmann-La Roche AG Verfahren zur durchführung von multiplexierter echtzeit-pcr unter verwendung von grossen stokes-verschiebungsfluoreszenzfarbstoffen
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4278002A2 (de) 2021-01-18 2023-11-22 Life Technologies Corporation Zusammensetzungen, kits und verfahren zur direkten amplifikation aus biologischen rohproben
WO2022159874A1 (en) 2021-01-25 2022-07-28 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
WO2022167570A1 (en) 2021-02-05 2022-08-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of human parainfluenza viruses 1-4 (hpiv 1-4)
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4314350A1 (de) 2021-03-23 2024-02-07 Life Technologies Corporation Zusammensetzungen, kits und verfahren für den variantenresistenten nachweis von zielvirussequenzen
EP4334472A1 (de) 2021-05-06 2024-03-13 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zum nachweis des hepatitis-delta-virus durch einen doppeltarget-test
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
CN117795093A (zh) 2021-06-25 2024-03-29 豪夫迈·罗氏有限公司 具有增加的灵敏度的用于进行温度多重pcr的方法
IL309650A (en) 2021-06-30 2024-02-01 Nunhems Bv Methods for selecting watermelon plants and plant parts containing a modified DWARF14 gene
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
US20230043483A1 (en) 2021-07-09 2023-02-09 Cepheld High-level multiplexing reaction vessel, reagent spotting device and associated methods
FR3125824A1 (fr) 2021-07-30 2023-02-03 Bforcure Dispositif et procédé de détection multiplexée de séquences d’acides nucléiques
WO2023014729A1 (en) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits, and methods for detection of nucleic acid sequence loads
WO2023020938A1 (en) 2021-08-16 2023-02-23 Nunhems B.V. Lettuce plant having delayed bolting
WO2023043280A1 (ko) 2021-09-17 2023-03-23 주식회사 씨젠 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
US20230121442A1 (en) 2021-10-06 2023-04-20 Johnson & Johnson Consumer Inc. Method of Quantifying Product Impact on Human Microbiome
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
AU2022379602A1 (en) 2021-10-26 2024-02-01 Caribou Biosciences, Inc. Exonuclease-coupled real-time endonuclease activity assay
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
WO2023089186A1 (en) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
WO2023104812A1 (en) 2021-12-09 2023-06-15 F. Hoffmann-La Roche Ag Mass based detection of pcr amplicons
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
US20230279004A1 (en) 2022-03-07 2023-09-07 Incyte Corporation Solid forms, salts, and processes of preparation of a cdk2 inhibitor
WO2023183826A1 (en) 2022-03-21 2023-09-28 Caredx, Inc. Methods for non-invasively monitoring organ health in cross-species transplantation
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
WO2023250288A2 (en) 2022-06-21 2023-12-28 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
WO2023248185A1 (en) 2022-06-24 2023-12-28 Mobidiag Oy Compact detection system
WO2024002924A2 (en) 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Fluorescent dyes with large stokes shift
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
WO2024006477A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Multiplex dye compounds
WO2024006924A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Systems and methods for analyte detection from multiplexed assays
WO2024003332A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Controlling for tagmentation sequencing library insert size using archaeal histone-like proteins
WO2024003260A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis
WO2024015766A1 (en) 2022-07-12 2024-01-18 Topogene Inc. Scalable, submicron-resolution replication of dna arrays
WO2024030985A1 (en) 2022-08-04 2024-02-08 Abbott Laboratories Assays for detecting monkeypox virus
WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus
WO2024044352A1 (en) 2022-08-26 2024-02-29 The General Hospital Corporation Methods and compositions for prognosis and treatment of dilated cardiomyopathy and heart failure
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318981A (en) * 1980-04-24 1982-03-09 Miles Laboratories, Inc. Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
CA1219824A (en) † 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
FR2540122B1 (fr) 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
DK150841C (da) 1984-12-19 1988-07-11 Medicotest Systemer As Forbindelsesled til etablering af elektrisk forbindelse med en engangshudelektrode
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
ES8706823A1 (es) 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4780405A (en) * 1985-06-25 1988-10-25 Siska Diagnostics, Inc. Carbonic anhydrase inhibitor-tagged nucleic acid probes
SE450813B (sv) † 1985-07-23 1987-08-03 Volcano Int Medical Ab Kneskydd med festbara stoddelar
FR2586704B1 (fr) 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US5011769A (en) * 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1284931C (en) † 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
JPS638396A (ja) † 1986-06-30 1988-01-14 Wakunaga Pharmaceut Co Ltd ポリ標識化オリゴヌクレオチド誘導体
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
CA1338457C (en) * 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US4914210A (en) * 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
FR2627590A1 (fr) * 1988-02-24 1989-08-25 Ire Celltarg Sa Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
EP0365627B1 (de) * 1988-03-24 1993-12-22 University Of Iowa Research Foundation Katalytische hybridisierungs-systeme zum nachweis von nukleinsäuresequenzen, die auf deren aktivität als kofaktoren in katalytischen reaktionen basieren in denen eine komplementäre, markierte nukleinsäureprobe gespalten wird
DE68919706T2 (de) * 1988-05-10 1995-04-13 Du Pont Verfahren zum schnellen nachweis von nukleinsäuren.
WO1989011548A1 (en) † 1988-05-20 1989-11-30 Cetus Corporation Immobilized sequence-specific probes
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
WO1990011372A1 (en) * 1989-03-21 1990-10-04 Collaborative Research, Inc. Multiplex dna diagnostic test
US5108892A (en) * 1989-08-03 1992-04-28 Promega Corporation Method of using a taq dna polymerase without 5'-3'-exonuclease activity
KR950013953B1 (ko) * 1990-01-26 1995-11-18 애보트 래보라토리즈 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법
CA2037673A1 (en) * 1990-03-07 1991-09-08 Nanibhushan Dattagupta Ribonuclease scission chain reaction
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase

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EP1302549B1 (de) 2007-06-27
CA2088683C (en) 2000-03-28
DE69132521T2 (de) 2001-09-06
EP0919565A3 (de) 2000-11-15
DE69132521D1 (de) 2001-03-01
US5487972A (en) 1996-01-30
EP0919565B2 (de) 2008-11-12
DK0543942T4 (da) 2007-02-19
EP1302549A3 (de) 2004-01-14
DK0543942T3 (da) 2001-06-18
ES2209033T3 (es) 2004-06-16
AU8651091A (en) 1992-03-02
US6214979B1 (en) 2001-04-10
US20080171315A1 (en) 2008-07-17
CA2088683A1 (en) 1992-02-07
DK1302549T3 (da) 2007-10-01
DK0919565T4 (da) 2009-01-12
US7141377B2 (en) 2006-11-28
ES2155058T3 (es) 2001-05-01
US20050255499A1 (en) 2005-11-17
JPH06500021A (ja) 1994-01-06
ATE198912T1 (de) 2001-02-15
DE69133574T2 (de) 2008-03-06
US5804375A (en) 1998-09-08
ATE252110T1 (de) 2003-11-15
ES2155058T5 (es) 2007-06-16
DE69133329T2 (de) 2004-08-05
DE69133329T3 (de) 2009-07-09
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DK0919565T3 (da) 2004-02-16
AU666837B2 (en) 1996-02-29
US5210015A (en) 1993-05-11
EP0919565A2 (de) 1999-06-02
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EP1302549A2 (de) 2003-04-16
DE69133329D1 (de) 2003-11-20
US7445900B2 (en) 2008-11-04
EP0543942B1 (de) 2001-01-24
ATE365812T1 (de) 2007-07-15
DE69132521T3 (de) 2007-07-05
WO1992002638A1 (en) 1992-02-20
EP0543942A1 (de) 1993-06-02
EP0919565B1 (de) 2003-10-15
ES2289190T3 (es) 2008-02-01

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