DE69113795T2 - Steroid 5-alpha-reduktase. - Google Patents
Steroid 5-alpha-reduktase.Info
- Publication number
- DE69113795T2 DE69113795T2 DE69113795T DE69113795T DE69113795T2 DE 69113795 T2 DE69113795 T2 DE 69113795T2 DE 69113795 T DE69113795 T DE 69113795T DE 69113795 T DE69113795 T DE 69113795T DE 69113795 T2 DE69113795 T2 DE 69113795T2
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- steroid
- alpha
- disclosed
- sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 title abstract 3
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101710169367 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Proteins 0.000 abstract 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 108010044467 Isoenzymes Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 206010068168 androgenetic alopecia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000009088 enzymatic function Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 210000004392 genitalia Anatomy 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000004634 pharmacological analysis method Methods 0.000 abstract 1
- 201000001514 prostate carcinoma Diseases 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01022—3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+) (1.3.1.22), i.e. cortisone alpha-reductase
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51766190A | 1990-04-30 | 1990-04-30 | |
| PCT/US1991/002866 WO1991017251A1 (en) | 1990-04-30 | 1991-04-25 | STEROID 5α-REDUCTASES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69113795D1 DE69113795D1 (de) | 1995-11-16 |
| DE69113795T2 true DE69113795T2 (de) | 1996-03-28 |
Family
ID=24060703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69113795T Expired - Fee Related DE69113795T2 (de) | 1990-04-30 | 1991-04-25 | Steroid 5-alpha-reduktase. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5422262A (de) |
| EP (1) | EP0528906B1 (de) |
| JP (1) | JP3294844B2 (de) |
| AT (1) | ATE129013T1 (de) |
| AU (1) | AU642501B2 (de) |
| CA (1) | CA2079454C (de) |
| DE (1) | DE69113795T2 (de) |
| WO (1) | WO1991017251A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0528906B1 (de) * | 1990-04-30 | 1995-10-11 | The Board Of Regents, The University Of Texas System | Steroid 5-alpha-reduktase |
| US5576191A (en) * | 1994-06-17 | 1996-11-19 | Immunex Corporation | Cytokine that binds ST2 |
| US5656613A (en) * | 1995-01-04 | 1997-08-12 | Merck & Co., Inc. | Treatment of hyperandrogenic conditions |
| US5834248A (en) * | 1995-02-10 | 1998-11-10 | Millennium Pharmaceuticals Inc. | Compositions and methods using rchd534, a gene uregulated by shear stress |
| US6359194B1 (en) | 1995-02-10 | 2002-03-19 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
| US20020170077A1 (en) * | 1995-02-10 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
| IT1276662B1 (it) * | 1995-04-04 | 1997-11-03 | Uni Degli Studi Camerino | Vaccini polinucleotidici |
| JP2000501603A (ja) * | 1995-12-07 | 2000-02-15 | ベイラー・カレッジ・オブ・メディスン | 尿生殖洞由来増殖因子のヌクレオチドおよびアミノ酸配列 |
| EP0904277A4 (de) | 1996-02-16 | 2003-01-22 | Millennium Pharm Inc | Zusammensetzungen und verfahren zur behandlung und diagnose von kardiovaskulären krankheiten |
| US5994319A (en) * | 1996-04-15 | 1999-11-30 | Dyad Pharmaceutical Corporation | Combination therapy for androgenic alopecia with antisense oligonucleotides and minoxidil |
| US6143950A (en) * | 1996-04-18 | 2000-11-07 | The Salk Institute For Biological Studies | Plant steroid 5α reductase, DET2 |
| EP0904295B1 (de) * | 1996-05-15 | 2005-08-10 | ALTANA Pharma AG | Verfahren zur trennung und bestimmung von hydrophoben proteinen durch dünnschichtchromatographie |
| WO1999037986A2 (en) | 1998-01-23 | 1999-07-29 | University Of Southern California | Androgen-metabolic gene mutations and prostate cancer risk |
| WO1999061055A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| AU2001253487A1 (en) * | 2000-04-13 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | 23155 novel protein human 5-alpha reductases and uses therefor |
| US6469150B1 (en) * | 2000-05-22 | 2002-10-22 | Pharmacopeia, Inc. | Cloning and characterization of genes encoding bradykinin B1 receptor homologues from five mammalian species |
| EP1352054A2 (de) * | 2000-10-30 | 2003-10-15 | Pharmacia Corporation | 11 alpha hydroxylase und oxidoreductase aus aspergillus ochraceus |
| CA2428784A1 (en) * | 2000-11-09 | 2002-05-16 | Astrazeneca Ab | Oral pharmaceutical composition containing a block copolymer |
| JP2002236307A (ja) * | 2001-02-09 | 2002-08-23 | Asahi Optical Co Ltd | ズームストロボ装置 |
| US7635598B2 (en) * | 2004-07-08 | 2009-12-22 | Biosearch Technologies, Inc. | Inducible fluorescence assay |
| US20070036740A1 (en) * | 2004-10-06 | 2007-02-15 | Reed Kenneth C | Modulation of hair growth |
| EP2392258B1 (de) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| FR2903999B1 (fr) * | 2006-07-19 | 2008-09-05 | Galderma Res & Dev S N C Snc | Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee |
| TR201908314T4 (tr) | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
| US20120156138A1 (en) * | 2009-04-14 | 2012-06-21 | Smith Larry J | Methods and Compositions for the Treatment of Medical Conditions Involving Cellular Reprogramming |
| IL295075A (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0528906B1 (de) * | 1990-04-30 | 1995-10-11 | The Board Of Regents, The University Of Texas System | Steroid 5-alpha-reduktase |
-
1991
- 1991-04-25 EP EP91909339A patent/EP0528906B1/de not_active Expired - Lifetime
- 1991-04-25 AT AT91909339T patent/ATE129013T1/de not_active IP Right Cessation
- 1991-04-25 JP JP50901491A patent/JP3294844B2/ja not_active Expired - Fee Related
- 1991-04-25 WO PCT/US1991/002866 patent/WO1991017251A1/en active IP Right Grant
- 1991-04-25 CA CA002079454A patent/CA2079454C/en not_active Expired - Fee Related
- 1991-04-25 AU AU78579/91A patent/AU642501B2/en not_active Ceased
- 1991-04-25 DE DE69113795T patent/DE69113795T2/de not_active Expired - Fee Related
- 1991-11-18 US US07/795,859 patent/US5422262A/en not_active Expired - Lifetime
-
1995
- 1995-06-01 US US08/457,616 patent/US5679521A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5422262A (en) | 1995-06-06 |
| WO1991017251A1 (en) | 1991-11-14 |
| EP0528906B1 (de) | 1995-10-11 |
| JP3294844B2 (ja) | 2002-06-24 |
| DE69113795D1 (de) | 1995-11-16 |
| EP0528906A1 (de) | 1993-03-03 |
| US5679521A (en) | 1997-10-21 |
| JPH05507405A (ja) | 1993-10-28 |
| CA2079454A1 (en) | 1991-10-31 |
| CA2079454C (en) | 2002-02-26 |
| ATE129013T1 (de) | 1995-10-15 |
| AU7857991A (en) | 1991-11-27 |
| AU642501B2 (en) | 1993-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |