DE68925904D1 - Makrocyclische chelate und verwendungsverfahren - Google Patents
Makrocyclische chelate und verwendungsverfahrenInfo
- Publication number
- DE68925904D1 DE68925904D1 DE68925904T DE68925904T DE68925904D1 DE 68925904 D1 DE68925904 D1 DE 68925904D1 DE 68925904 T DE68925904 T DE 68925904T DE 68925904 T DE68925904 T DE 68925904T DE 68925904 D1 DE68925904 D1 DE 68925904D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- chelate
- group
- use method
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19853888A | 1988-05-25 | 1988-05-25 | |
PCT/US1989/002201 WO1989011475A1 (en) | 1988-05-25 | 1989-05-24 | Macrocyclic chelates and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68925904D1 true DE68925904D1 (de) | 1996-04-11 |
DE68925904T2 DE68925904T2 (de) | 1996-10-31 |
Family
ID=22733797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68925904T Expired - Fee Related DE68925904T2 (de) | 1988-05-25 | 1989-05-24 | Makrocyclische chelate und verwendungsverfahren |
Country Status (9)
Country | Link |
---|---|
US (1) | US5428154A (de) |
EP (1) | EP0416033B1 (de) |
JP (2) | JPH0720989B2 (de) |
AT (1) | ATE134999T1 (de) |
AU (2) | AU630362B2 (de) |
CA (1) | CA1339015C (de) |
DE (1) | DE68925904T2 (de) |
IL (1) | IL90409A (de) |
WO (1) | WO1989011475A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
NZ229700A (en) * | 1988-06-24 | 1993-01-27 | Dow Chemical Co | Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments |
GB9111199D0 (en) * | 1991-05-23 | 1991-07-17 | Sandoz Ltd | Improvements in or relating to organic compounds |
US6139603A (en) * | 1989-02-22 | 2000-10-31 | L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Process for recovering oxygen |
US5292868A (en) * | 1989-05-26 | 1994-03-08 | Akzo N.V. | Chelating agents for attaching metal ions to proteins |
JPH04154729A (ja) * | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
US6403771B1 (en) | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
US5541287A (en) * | 1992-06-09 | 1996-07-30 | Neorx Corporation | Pretargeting methods and compounds |
US6022966A (en) * | 1993-11-22 | 2000-02-08 | Neorx Corporation | Pretargeting methods and compounds |
CA2100709C (en) * | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Method and means for site directed therapy |
PT590766E (pt) * | 1992-07-31 | 2000-07-31 | Australian Nuclear Science Tec | Complexos metalicos de hidroxiarilo contendo agentes quelantes de acido aminocarboxilico |
US5807535A (en) * | 1992-07-31 | 1998-09-15 | Australian Nuclear Science & Technology Organisation | Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents |
US5650134A (en) * | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
WO1995001346A1 (en) * | 1993-06-30 | 1995-01-12 | Akzo Nobel N.V. | Chelating compounds |
DE69526203T2 (de) * | 1994-01-12 | 2002-11-28 | Amersham Plc Little Chalfont | Biologische zielgerichtete mittel |
US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
GB9417873D0 (en) * | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US5814521A (en) * | 1995-10-06 | 1998-09-29 | Bayer Corporation | Metal ion determination by sandwich aggregation assay |
US6713046B1 (en) * | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
EP1032430A2 (de) | 1997-11-17 | 2000-09-06 | Research Corporation Technologies, Inc. | Mri-mittel zum nachweis von physiologischen mitteln |
US6372187B1 (en) | 1998-12-07 | 2002-04-16 | Mcdermott Technology, Inc. | Alkaline sorbent injection for mercury control |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
US6855859B2 (en) * | 1999-03-31 | 2005-02-15 | The Babcock & Wilcox Company | Method for controlling elemental mercury emissions |
US6284199B1 (en) * | 1999-03-31 | 2001-09-04 | Mcdermott Technology, Inc. | Apparatus for control of mercury |
US6328939B1 (en) | 1999-03-31 | 2001-12-11 | Mcdermott Technology, Inc. | Mercury removal in utility wet scrubber using a chelating agent |
WO2001041154A1 (en) | 1999-11-30 | 2001-06-07 | Scott Schenter | Method of producing actinium-225 and daughters |
CA2381123C (en) * | 2000-02-25 | 2011-10-04 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
LU90544B1 (en) * | 2000-03-14 | 2001-09-17 | Europ Economic Community | Bifunctional chelating agent |
US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
US6683162B2 (en) * | 2000-09-15 | 2004-01-27 | Sloan Kettering Institute Of Cancer Research | Targeted alpha particle therapy using actinium-255 conjugates |
US6517814B2 (en) | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
CN1622832A (zh) * | 2001-02-23 | 2005-06-01 | 布里斯托尔-迈尔斯斯奎布药品公司 | 用于动脉粥样硬化和易病变性斑块成像的标记的巨噬细胞清除剂受体拮抗剂 |
US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
US20030135108A1 (en) * | 2001-05-02 | 2003-07-17 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
EP1420688A4 (de) * | 2001-06-25 | 2005-08-31 | Us Gov Health & Human Serv | Makromolekulare abbildungsmittel für die leberabbildung |
US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
WO2004021996A2 (en) * | 2002-09-06 | 2004-03-18 | The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same |
US7371225B2 (en) | 2002-09-24 | 2008-05-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for convection enhanced delivery of therapeutic agents |
GB0308731D0 (en) * | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
EP1706452B1 (de) | 2003-12-30 | 2008-09-03 | The Regents of the University of California, Office of the President | Aromatische triamid-lanthanid-komplexe |
US20050171424A1 (en) * | 2004-01-13 | 2005-08-04 | The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services | Methods for imaging the lymphatic system using dendrimer-based contrast agents |
CA2581639C (en) * | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Luminescent lanthanide complexes |
US20060204443A1 (en) * | 2005-03-11 | 2006-09-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for tumor treatment using dendrimer conjugates |
US20070025910A1 (en) * | 2005-07-29 | 2007-02-01 | Norenberg Jeffrey P | Anticancer therapy |
EP2511266B1 (de) | 2006-07-10 | 2019-09-04 | The Regents of The University of California | Lumineszente 1-Hydroxy-2-Pyridinon-Chelate aus Lanthanoiden |
AU2007321881B2 (en) | 2006-08-15 | 2012-11-01 | The Regents Of The University Of California | Luminescent macrocyclic lanthanide complexes |
US8388936B2 (en) * | 2008-02-22 | 2013-03-05 | Mcw Research Foundation, Inc. | In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging |
US8388931B2 (en) | 2008-02-29 | 2013-03-05 | Marcos Lopez | 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors |
US8440827B2 (en) * | 2008-07-31 | 2013-05-14 | Duke University | Photolabile caged transition metal complexes and methods of using the same |
WO2011011592A1 (en) | 2009-07-22 | 2011-01-27 | Actinium Pharmaceuticals Inc. | Methods for generating radioimmunoconjugates |
US9273059B2 (en) | 2009-08-24 | 2016-03-01 | Lumiphore, Inc. | Macrocyclic HOPO chelators |
GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
KR101253100B1 (ko) * | 2010-02-16 | 2013-04-10 | 경북대학교 산학협력단 | 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 |
US11453652B2 (en) | 2013-03-15 | 2022-09-27 | Lumiphore, Inc. | Di-macrocycles |
FR3006688B1 (fr) * | 2013-06-06 | 2015-08-14 | Centre Nat Rech Scient | Chelates du plomb (ii) et du bismuth (iii) a base de tetraazacycloalcanes trans-di-n-picolinates |
UA122405C2 (uk) * | 2015-02-26 | 2020-11-10 | Сайєнконс Ас | Радіофармацевтичні розчини з переважними властивостями |
CN105807055B (zh) * | 2016-03-15 | 2017-10-10 | 中国烟草总公司郑州烟草研究院 | 一种检测二氯喹啉酸的试纸条及其制备方法和应用 |
EP3409297A1 (de) | 2017-05-30 | 2018-12-05 | AlfaRim Medial Holding B.V. | Optimaler 225actinium-213bismut-generator für alpha-partikelradioimmunotherapie |
US20200230266A1 (en) | 2017-09-20 | 2020-07-23 | Alfarim Medical Holding B.V. | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2186464A (en) * | 1939-10-18 | 1940-01-09 | Alframine Corp | Condensation product and method of preparing same |
US3860576A (en) * | 1972-04-26 | 1975-01-14 | Dow Chemical Co | N-substituted-tetra-azacyclotetradecanes |
US3936445A (en) * | 1973-07-04 | 1976-02-03 | Badische Anilin- & Soda-Fabrik Aktiengesellschaft | Process for the production of iron complexes of tetraazaannulenes |
US3979379A (en) * | 1975-04-25 | 1976-09-07 | The United States Of America As Represented By The Secretary Of The Army | Process for producing 1,3,5,7-tetraalkanoyl-1,3,5,7-octahydrotetrazocines |
DE2803528C2 (de) * | 1977-03-09 | 1984-10-18 | Tabushi, Iwao, Kyoto | Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen |
JPS53144592A (en) * | 1977-05-19 | 1978-12-15 | Tabuse Iwao | 122alkyll1*4*7*100tetrazacyclotridecane |
DE2740170C2 (de) * | 1977-05-17 | 1982-02-04 | Tabushi, Iwao, Kyoto | Alkylsubstituierte cyclische Tetraalkylentetramine |
US4543213A (en) * | 1978-07-24 | 1985-09-24 | The United States Of America As Represented By The United States Department Of Energy | Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes |
US4578517A (en) * | 1983-09-16 | 1986-03-25 | Air Products And Chemicals, Inc. | Polyalkylene polyamines from alkanolamine and ammonia or amines using group IIIB metal acid phosphate catalysts |
JPS61226751A (ja) * | 1985-03-30 | 1986-10-08 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料用処理液及びその処理方法 |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
US5132409A (en) * | 1987-01-12 | 1992-07-21 | Bracco Industria Chimica S.P.A. | Macrocyclic chelating agents and chelates thereof |
US5049667A (en) * | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
DE3713842A1 (de) * | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5064956A (en) * | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
US4987227A (en) * | 1988-10-21 | 1991-01-22 | The Research Foundation Of State University Of New York | Polyazamacrocycles and their metal complexes |
US5053503A (en) * | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
-
1989
- 1989-05-24 AT AT89907438T patent/ATE134999T1/de not_active IP Right Cessation
- 1989-05-24 DE DE68925904T patent/DE68925904T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP89907438A patent/EP0416033B1/de not_active Expired - Lifetime
- 1989-05-24 JP JP1507105A patent/JPH0720989B2/ja not_active Expired - Fee Related
- 1989-05-24 AU AU38428/89A patent/AU630362B2/en not_active Ceased
- 1989-05-24 WO PCT/US1989/002201 patent/WO1989011475A1/en active IP Right Grant
- 1989-05-25 IL IL9040989A patent/IL90409A/en active IP Right Grant
- 1989-05-25 CA CA000600714A patent/CA1339015C/en not_active Expired - Fee Related
-
1993
- 1993-01-28 AU AU32108/93A patent/AU655704B2/en not_active Ceased
- 1993-10-22 US US08/140,714 patent/US5428154A/en not_active Expired - Lifetime
-
1994
- 1994-07-11 JP JP6181867A patent/JP2582341B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU630362B2 (en) | 1992-10-29 |
AU3210893A (en) | 1993-04-01 |
JP2582341B2 (ja) | 1997-02-19 |
CA1339015C (en) | 1997-03-25 |
US5428154A (en) | 1995-06-27 |
AU3842889A (en) | 1989-12-12 |
IL90409A (en) | 1996-09-12 |
JPH0720989B2 (ja) | 1995-03-08 |
EP0416033A4 (en) | 1991-04-17 |
IL90409A0 (en) | 1990-01-18 |
ATE134999T1 (de) | 1996-03-15 |
DE68925904T2 (de) | 1996-10-31 |
WO1989011475A1 (en) | 1989-11-30 |
JPH07258281A (ja) | 1995-10-09 |
JPH03503531A (ja) | 1991-08-08 |
AU655704B2 (en) | 1995-01-05 |
EP0416033B1 (de) | 1996-03-06 |
EP0416033A1 (de) | 1991-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE68925904T2 (de) | Makrocyclische chelate und verwendungsverfahren | |
DE69527759T2 (de) | Mono -und multimere verbindungen mit erhöhter relaxation | |
ATE138809T1 (de) | Anwendung von chelat-komplexen | |
EA199800998A2 (ru) | Хелатные соединения металлов с макроциклическими полиаминокарбоновыми соединениями и их использование для диагностических исследований | |
ATE173336T1 (de) | Hydroxy-aryl metallchelate für bildformung zur nmr diagnose | |
NO980648L (no) | Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander | |
DE69120826T2 (de) | Chelatbildende mittel | |
DE69503055D1 (de) | Makrozyclische chelante, ihre chelate und verwendungen in diagnostik | |
BR9509741A (pt) | Composto e uso de composto | |
NO980647L (no) | Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av biokonjugater av metallkomplekser av nitrogeninneholdende makrocykliske ligander | |
DE59709024D1 (de) | Pseudopolyrotaxane | |
RS49929B (sr) | Referentno jedinjenje za upotrebu u analizi šarži levosimendana | |
ATE112962T1 (de) | Mittel gegen juckreiz. | |
CA2190727A1 (en) | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging | |
DE440606T1 (de) | Macrocyclische chelatisierungsmittel und daraus hergestellte chelate. | |
ATE190053T1 (de) | Aromatische aminsubstituierte liganden mit verbrückten stickstoff-und schwefeldonatoratomen für bildformung | |
NO932251L (no) | Chelaterende forbindelser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |