DE68921635D1 - Kennzeichnung von makromolekülen in interaktion mit mindestens zwei liganden auf einem fühler. - Google Patents

Kennzeichnung von makromolekülen in interaktion mit mindestens zwei liganden auf einem fühler.

Info

Publication number
DE68921635D1
DE68921635D1 DE68921635T DE68921635T DE68921635D1 DE 68921635 D1 DE68921635 D1 DE 68921635D1 DE 68921635 T DE68921635 T DE 68921635T DE 68921635 T DE68921635 T DE 68921635T DE 68921635 D1 DE68921635 D1 DE 68921635D1
Authority
DE
Germany
Prior art keywords
macromolecule
ligand
ligands
interactions
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68921635T
Other languages
English (en)
Other versions
DE68921635T2 (de
Inventor
Magnus Malmqvist
Robert Karlsson
Anita Larsson
Joergen Sjoedahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Pharmacia Biosensor AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE19888804074A external-priority patent/SE8804074D0/xx
Application filed by Pharmacia Biosensor AB filed Critical Pharmacia Biosensor AB
Publication of DE68921635D1 publication Critical patent/DE68921635D1/de
Application granted granted Critical
Publication of DE68921635T2 publication Critical patent/DE68921635T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/211—Ellipsometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE68921635T 1988-11-10 1989-11-09 Kennzeichnung von makromolekülen in interaktion mit mindestens zwei liganden auf einem fühler. Expired - Lifetime DE68921635T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE19888804074A SE8804074D0 (sv) 1988-11-10 1988-11-10 Sensorenhet och dess anvaendning i biosensorsystem
SE8902043A SE8902043L (sv) 1988-11-10 1989-06-05 Foerfarande foer karakterisering av makromolekyler
PCT/SE1989/000644 WO1990005306A1 (en) 1988-11-10 1989-11-09 Characterizing macromolecules interacting with at least two ligands on a sensor

Publications (2)

Publication Number Publication Date
DE68921635D1 true DE68921635D1 (de) 1995-04-13
DE68921635T2 DE68921635T2 (de) 1995-10-05

Family

ID=26660348

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921635T Expired - Lifetime DE68921635T2 (de) 1988-11-10 1989-11-09 Kennzeichnung von makromolekülen in interaktion mit mindestens zwei liganden auf einem fühler.

Country Status (7)

Country Link
US (1) US5554541A (de)
EP (1) EP0442930B1 (de)
JP (1) JP2803877B2 (de)
AT (1) ATE119671T1 (de)
DE (1) DE68921635T2 (de)
SE (1) SE8902043L (de)
WO (1) WO1990005306A1 (de)

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SE9102074D0 (sv) * 1991-07-03 1991-07-03 Kabi Pharmacia Ab Tomour antigen specific antibody
WO1993025910A1 (en) * 1992-06-05 1993-12-23 Pharmacia Biosensor Ab Assay for multiple analytes with co-immobilized ligands
SE504507C2 (sv) * 1993-05-24 1997-02-24 Pharmacia Biosensor Ab Sätt att bestämma bindningsegenskaper hos ligander med låg molekylvikt
US6020047A (en) * 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
US6180288B1 (en) 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
US6489102B2 (en) 1999-08-05 2002-12-03 Wisconsin Alumni Research Foundation Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
ATE295541T1 (de) * 1999-06-18 2005-05-15 Biacore Ab Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
JP4684507B2 (ja) 1999-07-05 2011-05-18 ノバルティス アーゲー センサープラットホームを使用する方法
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US7524625B2 (en) * 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
EP1392504A4 (de) * 2001-04-02 2008-03-05 Agilent Technologies Inc Sensorflächen zur erfassung von analyten
AU2002258702A1 (en) * 2001-04-02 2002-10-15 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
JP4173725B2 (ja) * 2001-12-25 2008-10-29 富士フイルム株式会社 エバネッセント波を利用したセンサー
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US20040101920A1 (en) * 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
DE10319572A1 (de) * 2003-04-30 2004-11-25 Kist-Europe Forschungsgesellschaft Mbh Verfahren zur Bestimmung der Konzentration eines Analyten
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
EP2102659B1 (de) * 2006-12-13 2012-10-31 Biosensor Applications Sweden AB (Publ) Ständig wiederholbares verfahren zum nachweis von antigenen in einem testvolumen
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same

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EP0075353B1 (de) * 1981-09-18 1987-08-19 Battelle Memorial Institute Verfahren und Vorrichtung zur Bestimmung von gelösten Stoffen mit Hilfe eines optischen Wellenleiters
US4659678A (en) * 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
GB8328520D0 (en) * 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
GB8417301D0 (en) * 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
EP0184600B1 (de) * 1984-12-10 1990-03-14 Prutec Limited Verfahren zum optischen Nachweis von Parametern von Substanzen in einem flüssigen Analyt
EP0248038A1 (de) * 1985-10-22 1987-12-09 Murex Corporation Idiotypisches antigen-konjugierungs-bindetestverfahren
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
CA1305921C (en) * 1987-01-30 1992-08-04 Eric K. Gustafson Diffraction immunoassay and reagents
US5104790A (en) * 1987-06-29 1992-04-14 Genetic Systems Corporation Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
US4916075A (en) * 1987-08-19 1990-04-10 Ohmicron Corporation Differential homogeneous immunosensor device

Also Published As

Publication number Publication date
SE8902043L (sv) 1990-05-11
EP0442930A1 (de) 1991-08-28
ATE119671T1 (de) 1995-03-15
JPH04501607A (ja) 1992-03-19
DE68921635T2 (de) 1995-10-05
WO1990005306A1 (en) 1990-05-17
US5554541A (en) 1996-09-10
EP0442930B1 (de) 1995-03-08
JP2803877B2 (ja) 1998-09-24
SE8902043D0 (sv) 1989-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE BIO-SCIENCES AB, UPPSALA, SE