DE602005023714D1 - Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2) - Google Patents
Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)Info
- Publication number
- DE602005023714D1 DE602005023714D1 DE602005023714T DE602005023714T DE602005023714D1 DE 602005023714 D1 DE602005023714 D1 DE 602005023714D1 DE 602005023714 T DE602005023714 T DE 602005023714T DE 602005023714 T DE602005023714 T DE 602005023714T DE 602005023714 D1 DE602005023714 D1 DE 602005023714D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- bmp
- bone morphogenetic
- morphogenetic protein
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
- C07K14/503—Fibroblast growth factors [FGF] basic FGF [bFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54701204P | 2004-02-20 | 2004-02-20 | |
PCT/US2005/005880 WO2005082005A2 (en) | 2004-02-20 | 2005-02-22 | Positive modulator of bone morphogenic protein-2 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005023714D1 true DE602005023714D1 (de) | 2010-11-04 |
Family
ID=34910841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005023714T Active DE602005023714D1 (de) | 2004-02-20 | 2005-02-22 | Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2) |
Country Status (7)
Country | Link |
---|---|
US (3) | US7482427B2 (de) |
EP (1) | EP1725576B1 (de) |
JP (1) | JP4895826B2 (de) |
AT (1) | ATE482228T1 (de) |
CA (1) | CA2555583A1 (de) |
DE (1) | DE602005023714D1 (de) |
WO (1) | WO2005082005A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
US8227411B2 (en) | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
WO2005082005A2 (en) | 2004-02-20 | 2005-09-09 | Biosurface Engineering Technologies, Inc., Et Al. | Positive modulator of bone morphogenic protein-2 |
US7767221B2 (en) | 2004-03-05 | 2010-08-03 | The Trustees Of Columbia University In The City Of New York | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone |
WO2006135901A2 (en) * | 2005-06-13 | 2006-12-21 | Maria-Grazia Ascenzi | Method and system for modeling bone structure |
US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
EP2046350A4 (de) * | 2006-06-22 | 2011-09-14 | Biosurface Eng Tech Inc | Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese |
US20110182904A1 (en) * | 2006-09-05 | 2011-07-28 | Deborah Zimmerman | Antibodies to bone morphogenic proteins and receptors therefor and methods for their use |
US20100047309A1 (en) * | 2006-12-06 | 2010-02-25 | Lu Helen H | Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods |
WO2008100534A2 (en) * | 2007-02-12 | 2008-08-21 | Trustees Of Columbia University In The City Of New York | Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement |
US8753391B2 (en) | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
US20080255041A1 (en) * | 2007-04-11 | 2008-10-16 | Ebi, L.P. | Treatment of annulus fibrosis defects |
US9056150B2 (en) * | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
JP2013509963A (ja) | 2009-11-09 | 2013-03-21 | スポットライト テクノロジー パートナーズ エルエルシー | 断片化ヒドロゲル |
CN102695500A (zh) | 2009-11-09 | 2012-09-26 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
US11078248B2 (en) | 2010-03-19 | 2021-08-03 | Lifenet Health | BMP peptides and methods of use |
US9809635B2 (en) * | 2010-03-19 | 2017-11-07 | Lifenet Health | BMP-2 peptides and methods of use |
CN102886075B (zh) * | 2012-09-19 | 2015-01-14 | 中南大学 | 人体硬组织修复材料及其制备方法 |
EP2983643A4 (de) | 2013-04-12 | 2016-12-28 | Univ Columbia | Verfahren für wirtszellen-homing und zahnmarkregeneration |
Family Cites Families (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272204A (en) * | 1965-09-22 | 1966-09-13 | Ethicon Inc | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands |
US4172128A (en) * | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
GB1537448A (en) * | 1976-08-20 | 1978-12-29 | Sumitomo Electric Industries | Vascular prostheses and process for production thereof |
US5197977A (en) * | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
US4842575A (en) * | 1984-01-30 | 1989-06-27 | Meadox Medicals, Inc. | Method for forming impregnated synthetic vascular grafts |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
GB8430265D0 (en) * | 1984-11-30 | 1985-01-09 | Vascutek Ltd | Vascular graft |
US5859208A (en) * | 1988-07-06 | 1999-01-12 | Fiddes; John C. | Human basic fibroblast growth factor analog |
US5658894A (en) * | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
FI890312A (fi) * | 1988-01-25 | 1989-07-26 | Oncogen | Amfiregulin: ett nytt bifunktionellt tillvaext modulerande glykoprotein. |
US6919308B2 (en) | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
US5202311A (en) * | 1988-08-19 | 1993-04-13 | Children's Medical Center Corporation | Stabilized fgf composition |
US5108436A (en) * | 1988-09-29 | 1992-04-28 | Collagen Corporation | Implant fixation |
US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5576288A (en) * | 1989-04-27 | 1996-11-19 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US5380536A (en) * | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
US5270197A (en) * | 1990-12-20 | 1993-12-14 | The Children's Medical Center Corporation | Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor |
GB9101645D0 (en) * | 1991-01-25 | 1991-03-06 | British Bio Technology | Compounds |
US5648458A (en) * | 1992-05-06 | 1997-07-15 | Affymax Technologies N.V. | Peptides and compounds that bind to ELAM-1 |
US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
US5326695A (en) * | 1992-05-15 | 1994-07-05 | Ludwig Institute For Cancer Research | Platelet derived growth factor agonists |
US5763584A (en) * | 1992-05-18 | 1998-06-09 | Genentech, Inc. | Receptor activation with hepatocyte growth factor agonists |
EP0642585B1 (de) * | 1992-05-18 | 2005-12-28 | Genentech, Inc. | Aktivierung von Rezeptoren fähig zur Oligomerisierung durch Verwendung von fusionierten Rezeptor Liganden |
US5643756A (en) * | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
US5679673A (en) | 1992-09-24 | 1997-10-21 | The United States Of America, Represented By The Department Of Health And Human Services | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders |
US6057133A (en) * | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
US5674977A (en) * | 1993-02-05 | 1997-10-07 | The Ontario Cancer Institute | Branched synthetic peptide conjugate |
US6001364A (en) * | 1993-05-05 | 1999-12-14 | Gryphon Sciences | Hetero-polyoxime compounds and their preparation by parallel assembly |
US6174530B1 (en) | 1993-05-05 | 2001-01-16 | Gryphon Sciences | Homogeneous polyoxime compositions and their preparation by parallel assembly |
US5563046A (en) * | 1993-08-02 | 1996-10-08 | Celtrix Pharmaceuticals, Inc. | Fusion polypeptides and proteins |
US6284503B1 (en) | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
US5952304A (en) * | 1993-10-22 | 1999-09-14 | Trigen Limited | Platelet-derived growth factor analogues |
US5830851A (en) * | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5861476A (en) * | 1994-02-02 | 1999-01-19 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5786331A (en) * | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5880096A (en) * | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5635599A (en) * | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
US5635597A (en) * | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
US5665114A (en) * | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
US5650234A (en) * | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
US5509899A (en) * | 1994-09-22 | 1996-04-23 | Boston Scientific Corp. | Medical device with lubricious coating |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5919570A (en) * | 1995-02-01 | 1999-07-06 | Schneider Inc. | Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices |
US6231600B1 (en) * | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6638291B1 (en) | 1995-04-20 | 2003-10-28 | Micrus Corporation | Three dimensional, low friction vasoocclusive coil, and method of manufacture |
US6171326B1 (en) | 1998-08-27 | 2001-01-09 | Micrus Corporation | Three dimensional, low friction vasoocclusive coil, and method of manufacture |
US5654276A (en) * | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US5668110A (en) * | 1995-06-07 | 1997-09-16 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
US6491965B1 (en) * | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
JP4193917B2 (ja) * | 1995-12-18 | 2008-12-10 | アンジオデバイス インターナショナル ゲーエムベーハー | 架橋ポリマー組成物およびその使用方法 |
US6458889B1 (en) * | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US5687136A (en) | 1996-04-04 | 1997-11-11 | The Regents Of The University Of Michigan | User-driven active guidance system |
GB9608882D0 (en) * | 1996-04-30 | 1996-07-03 | Luthra Ajay K | Non-thrombogenic and anti-thrombogenic polymers |
US5811151A (en) | 1996-05-31 | 1998-09-22 | Medtronic, Inc. | Method of modifying the surface of a medical device |
US5916585A (en) * | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
US5965532A (en) * | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
US6060534A (en) * | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
US6306165B1 (en) * | 1996-09-13 | 2001-10-23 | Meadox Medicals | ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin |
CN1127568C (zh) | 1996-10-16 | 2003-11-12 | 津莫吉尼蒂克斯公司 | 成纤维细胞生长因子同系物 |
US5994104A (en) * | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
US6214795B1 (en) * | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
CA2280931C (en) * | 1997-02-07 | 2009-05-05 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US7041641B2 (en) * | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
EP1001968B1 (de) * | 1997-06-13 | 2004-12-22 | Gryphon Therapeutics, Inc. | Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen |
US6168784B1 (en) * | 1997-09-03 | 2001-01-02 | Gryphon Sciences | N-terminal modifications of RANTES and methods of use |
US5945457A (en) * | 1997-10-01 | 1999-08-31 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science | Process for preparing biologically compatible polymers and their use in medical devices |
US6136015A (en) | 1998-08-25 | 2000-10-24 | Micrus Corporation | Vasoocclusive coil |
US6159165A (en) | 1997-12-05 | 2000-12-12 | Micrus Corporation | Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand |
US5955588A (en) | 1997-12-22 | 1999-09-21 | Innerdyne, Inc. | Non-thrombogenic coating composition and methods for using same |
US6410044B1 (en) * | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
US6121236A (en) * | 1998-03-24 | 2000-09-19 | The Children's Medical Center Corporation | Multivalent ligands which modulate angiogenesis |
DE19814057B4 (de) * | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Anordnung zur optischen Kohärenztomographie und Kohärenztopographie |
US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
US6113629A (en) | 1998-05-01 | 2000-09-05 | Micrus Corporation | Hydrogel for the therapeutic treatment of aneurysms |
US6168615B1 (en) | 1998-05-04 | 2001-01-02 | Micrus Corporation | Method and apparatus for occlusion and reinforcement of aneurysms |
US6656218B1 (en) | 1998-07-24 | 2003-12-02 | Micrus Corporation | Intravascular flow modifier and reinforcement device |
US6165194A (en) | 1998-07-24 | 2000-12-26 | Micrus Corporation | Intravascular flow modifier and reinforcement device |
JP2002524108A (ja) * | 1998-07-28 | 2002-08-06 | インナーダイン, インコーポレイテッド | 吸収性近接照射療法および化学療法送達デバイスならびに方法 |
US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
US6514534B1 (en) * | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
KR20010085743A (ko) * | 1998-08-31 | 2001-09-07 | 추후제출 | 지질 매트릭스 보조 화학결합 및 막 폴리펩티드의 합성 |
US6342591B1 (en) | 1998-09-22 | 2002-01-29 | Biosurface Engineering Technologies, Inc. | Amphipathic coating for modulating cellular adhesion composition and methods |
US6596699B2 (en) * | 1998-09-22 | 2003-07-22 | Biosurface Engineering Technologies, Inc. | Nucleic acid coating compositions and methods |
US6921811B2 (en) * | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
US6548634B1 (en) | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
US6366794B1 (en) * | 1998-11-20 | 2002-04-02 | The University Of Connecticut | Generic integrated implantable potentiostat telemetry unit for electrochemical sensors |
US6383204B1 (en) | 1998-12-15 | 2002-05-07 | Micrus Corporation | Variable stiffness coil for vasoocclusive devices |
US6102932A (en) | 1998-12-15 | 2000-08-15 | Micrus Corporation | Intravascular device push wire delivery system |
DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
US6221066B1 (en) | 1999-03-09 | 2001-04-24 | Micrus Corporation | Shape memory segmented detachable coil |
ES2255257T3 (es) | 1999-04-22 | 2006-06-16 | Eidgenossische Technische Hochschule (Eth) | Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina. |
US6368347B1 (en) * | 1999-04-23 | 2002-04-09 | Sulzer Vascutek Ltd. | Expanded polytetrafluoroethylene vascular graft with coating |
US6309660B1 (en) * | 1999-07-28 | 2001-10-30 | Edwards Lifesciences Corp. | Universal biocompatible coating platform for medical devices |
US6458162B1 (en) * | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
TR200201687T2 (tr) * | 1999-12-28 | 2003-02-21 | Osteotech, Inc | Kalsiyum fosfat kemik aşı maddesi ve ondan üretilmiş osteoimplant. |
US6585765B1 (en) * | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
AU2002218755A1 (en) | 2000-07-10 | 2002-01-21 | Stork Food & Dairy Systems B.V. | Homogenization valve |
KR20030032977A (ko) | 2000-07-12 | 2003-04-26 | 그리폰 테라퓨틱스, 인코포레이티드 | 키모카인 수용체 조절제, 제조 및 사용 |
RU2003109746A (ru) | 2000-09-08 | 2005-01-27 | Грифон Терапьютикс, Инк. (Us) | Синтетические белки, стимулирующие эритропоэз |
AU2002240201A1 (en) | 2001-02-02 | 2002-08-19 | Yale University | Peptides for facilitating composite receptor expression and translocation of macromolecules |
US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
CA2747159A1 (en) * | 2001-05-07 | 2002-11-07 | Queen's University At Kingston | Biodegradable elastomer and method of preparing same |
US7297343B2 (en) * | 2001-07-31 | 2007-11-20 | Biosurface Engineering Technologies, Inc. | Bioactive medical films |
US6866155B2 (en) | 2002-08-16 | 2005-03-15 | Trion Industries, Inc. | Product display rack |
US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
US7598224B2 (en) * | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
US8227411B2 (en) * | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
US7468210B1 (en) * | 2002-12-10 | 2008-12-23 | Biosurface Engineering Technologies, Inc. | Cross-linked heparin coatings and methods |
US20050148512A1 (en) * | 2003-11-10 | 2005-07-07 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
US7414028B1 (en) * | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
US20060024347A1 (en) * | 2004-02-10 | 2006-02-02 | Biosurface Engineering Technologies, Inc. | Bioactive peptide coatings |
US7528105B1 (en) * | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
US7351280B2 (en) | 2004-02-10 | 2008-04-01 | New York University | Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment |
US7671012B2 (en) * | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
WO2005082005A2 (en) | 2004-02-20 | 2005-09-09 | Biosurface Engineering Technologies, Inc., Et Al. | Positive modulator of bone morphogenic protein-2 |
US20090111743A1 (en) * | 2005-02-25 | 2009-04-30 | Biosurface Engineering Technologies, Inc. | Cysteine-branched heparin-binding growth factor analogs |
US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
EP2046350A4 (de) | 2006-06-22 | 2011-09-14 | Biosurface Eng Tech Inc | Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese |
-
2005
- 2005-02-22 WO PCT/US2005/005880 patent/WO2005082005A2/en not_active Application Discontinuation
- 2005-02-22 CA CA002555583A patent/CA2555583A1/en not_active Abandoned
- 2005-02-22 US US11/064,039 patent/US7482427B2/en not_active Expired - Lifetime
- 2005-02-22 DE DE602005023714T patent/DE602005023714D1/de active Active
- 2005-02-22 AT AT05723656T patent/ATE482228T1/de not_active IP Right Cessation
- 2005-02-22 EP EP05723656A patent/EP1725576B1/de active Active
- 2005-02-22 JP JP2006554324A patent/JP4895826B2/ja active Active
-
2008
- 2008-01-31 US US12/023,801 patent/US10611810B2/en active Active
-
2016
- 2016-08-18 US US15/240,977 patent/US9670258B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2555583A1 (en) | 2005-09-09 |
EP1725576A4 (de) | 2008-08-20 |
WO2005082005A8 (en) | 2006-05-11 |
US7482427B2 (en) | 2009-01-27 |
EP1725576A2 (de) | 2006-11-29 |
US10611810B2 (en) | 2020-04-07 |
WO2005082005A3 (en) | 2006-07-27 |
JP2007525499A (ja) | 2007-09-06 |
JP4895826B2 (ja) | 2012-03-14 |
US20160376334A1 (en) | 2016-12-29 |
ATE482228T1 (de) | 2010-10-15 |
US20080166392A1 (en) | 2008-07-10 |
US9670258B2 (en) | 2017-06-06 |
EP1725576B1 (de) | 2010-09-22 |
WO2005082005A2 (en) | 2005-09-09 |
US20050196425A1 (en) | 2005-09-08 |
US20150353615A9 (en) | 2015-12-10 |
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