DE602004013372D1 - Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung - Google Patents

Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung

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Publication number
DE602004013372D1
DE602004013372D1 DE602004013372T DE602004013372T DE602004013372D1 DE 602004013372 D1 DE602004013372 D1 DE 602004013372D1 DE 602004013372 T DE602004013372 T DE 602004013372T DE 602004013372 T DE602004013372 T DE 602004013372T DE 602004013372 D1 DE602004013372 D1 DE 602004013372D1
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DE
Germany
Prior art keywords
preparation
fusion proteins
antibody portions
portion including
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004013372T
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English (en)
Other versions
DE602004013372T2 (de
Inventor
Scott Lauder
Stephen D Gillies
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Merck Patent GmbH
Original Assignee
Merck Patent GmbH
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Publication of DE602004013372D1 publication Critical patent/DE602004013372D1/de
Application granted granted Critical
Publication of DE602004013372T2 publication Critical patent/DE602004013372T2/de
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2046—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
DE602004013372T 2003-12-30 2004-12-21 Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung Active DE602004013372T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53340603P 2003-12-30 2003-12-30
US533406P 2003-12-30
PCT/EP2004/014555 WO2005063820A2 (en) 2003-12-30 2004-12-21 Il-7 fusion proteins

Publications (2)

Publication Number Publication Date
DE602004013372D1 true DE602004013372D1 (de) 2008-06-05
DE602004013372T2 DE602004013372T2 (de) 2009-07-02

Family

ID=34738862

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004013372T Active DE602004013372T2 (de) 2003-12-30 2004-12-21 Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung

Country Status (16)

Country Link
US (3) US7323549B2 (de)
EP (1) EP1699822B1 (de)
JP (1) JP2008502317A (de)
KR (1) KR101163424B1 (de)
CN (1) CN100467488C (de)
AT (1) ATE393169T1 (de)
AU (1) AU2004309050B2 (de)
BR (1) BRPI0418286A (de)
CA (1) CA2551915C (de)
DE (1) DE602004013372T2 (de)
DK (1) DK1699822T3 (de)
ES (1) ES2305886T3 (de)
PL (1) PL1699822T3 (de)
PT (1) PT1699822E (de)
RU (1) RU2369616C2 (de)
WO (1) WO2005063820A2 (de)

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PT1699822E (pt) 2008-07-30
JP2008502317A (ja) 2008-01-31
KR101163424B1 (ko) 2012-07-13
US20050164352A1 (en) 2005-07-28
KR20060112673A (ko) 2006-11-01
DE602004013372T2 (de) 2009-07-02
US8338575B2 (en) 2012-12-25
BRPI0418286A (pt) 2007-05-02
US7960514B2 (en) 2011-06-14
AU2004309050A1 (en) 2005-07-14
PL1699822T3 (pl) 2008-08-29
AU2004309050B2 (en) 2010-10-14
CA2551915C (en) 2015-06-23
WO2005063820A2 (en) 2005-07-14
RU2006127552A (ru) 2008-02-10
CN1898262A (zh) 2007-01-17
RU2369616C2 (ru) 2009-10-10
CN100467488C (zh) 2009-03-11
ES2305886T3 (es) 2008-11-01
US20090010875A1 (en) 2009-01-08
WO2005063820A3 (en) 2006-03-09
US7323549B2 (en) 2008-01-29
US20110243887A1 (en) 2011-10-06
EP1699822B1 (de) 2008-04-23
ATE393169T1 (de) 2008-05-15
CA2551915A1 (en) 2005-07-14
EP1699822A2 (de) 2006-09-13

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