DE60143569D1 - Zweidimensionales spektrales bilderstellungssystem - Google Patents
Zweidimensionales spektrales bilderstellungssystemInfo
- Publication number
- DE60143569D1 DE60143569D1 DE60143569T DE60143569T DE60143569D1 DE 60143569 D1 DE60143569 D1 DE 60143569D1 DE 60143569 T DE60143569 T DE 60143569T DE 60143569 T DE60143569 T DE 60143569T DE 60143569 D1 DE60143569 D1 DE 60143569D1
- Authority
- DE
- Germany
- Prior art keywords
- spectra
- detection region
- identifiable
- probes
- labels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
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Families Citing this family (219)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US7253435B2 (en) | 1999-04-15 | 2007-08-07 | Millipore Corporation | Particles with light-polarizing codes |
US8497131B2 (en) * | 1999-10-06 | 2013-07-30 | Becton, Dickinson And Company | Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules |
US7192778B2 (en) * | 1999-10-06 | 2007-03-20 | Natan Michael J | Surface enhanced spectroscopy-active composite nanoparticles |
US20020090650A1 (en) * | 2000-04-06 | 2002-07-11 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
US6734420B2 (en) * | 2000-04-06 | 2004-05-11 | Quantum Dot Corporation | Differentiable spectral bar code methods and systems |
US6898367B2 (en) * | 2000-06-17 | 2005-05-24 | Leica Microsystems Heidelberg Gmbh | Method and instrument for microscopy |
US6586190B2 (en) * | 2000-08-18 | 2003-07-01 | Syngenta Participations Ag | Parallel high throughput method and kit |
EP2085781B2 (de) | 2000-10-06 | 2020-03-11 | Life Technologies Corporation | Zellen mit spektralen Signaturen und Verfahren zur Herstellung und Verwendung davon |
EP1395601A4 (de) * | 2000-10-18 | 2006-04-12 | Vitra Bioscience Inc | Multiplexiertes zellanalysesystem |
US6892949B2 (en) * | 2000-12-29 | 2005-05-17 | Siemens Logistics And Assembly Systems Inc. | Low visual impact labeling method and system |
US6861263B2 (en) | 2001-01-26 | 2005-03-01 | Surromed, Inc. | Surface-enhanced spectroscopy-active sandwich nanoparticles |
US6586745B2 (en) * | 2001-06-19 | 2003-07-01 | Southwest Research Institute | Ultraviolet target designator and methodology |
US20030148544A1 (en) * | 2001-06-28 | 2003-08-07 | Advanced Research And Technology Institute, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US6819845B2 (en) | 2001-08-02 | 2004-11-16 | Ultradots, Inc. | Optical devices with engineered nonlinear nanocomposite materials |
US6710366B1 (en) | 2001-08-02 | 2004-03-23 | Ultradots, Inc. | Nanocomposite materials with engineered properties |
US6794265B2 (en) * | 2001-08-02 | 2004-09-21 | Ultradots, Inc. | Methods of forming quantum dots of Group IV semiconductor materials |
US20030066998A1 (en) * | 2001-08-02 | 2003-04-10 | Lee Howard Wing Hoon | Quantum dots of Group IV semiconductor materials |
US7309568B2 (en) * | 2001-09-26 | 2007-12-18 | Hitachi, Ltd. | Method in inspecting DNA and apparatus therefor |
DE10153829A1 (de) * | 2001-11-05 | 2003-05-28 | Bayer Ag | Assay basierend auf dotierten Nanoteilchen |
US8271202B1 (en) | 2002-02-11 | 2012-09-18 | Fernandez Dennis S | Modified host bio-data management |
US20040026684A1 (en) * | 2002-04-02 | 2004-02-12 | Nanosys, Inc. | Nanowire heterostructures for encoding information |
US6996292B1 (en) * | 2002-04-18 | 2006-02-07 | Sandia Corporation | Staring 2-D hadamard transform spectral imager |
GB2387903A (en) * | 2002-04-24 | 2003-10-29 | Smartbead Technologies Ltd | Multiparameter analysis using tagged molecules |
US6788416B2 (en) * | 2002-05-22 | 2004-09-07 | Texas Instruments Incorporated | Method and apparatus for dynamic DMD testing |
GB0216197D0 (en) * | 2002-07-12 | 2002-08-21 | Univ Strathclyde | Serrs active particles |
JPWO2004025550A1 (ja) * | 2002-08-19 | 2006-01-12 | 福井 眞彌 | 暗号情報内有材料、その識別方法およびその識別システム |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7901630B2 (en) * | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7508608B2 (en) * | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US20050227252A1 (en) * | 2002-08-20 | 2005-10-13 | Moon John A | Diffraction grating-based encoded articles for multiplexed experiments |
US7164533B2 (en) * | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7399643B2 (en) * | 2002-09-12 | 2008-07-15 | Cyvera Corporation | Method and apparatus for aligning microbeads in order to interrogate the same |
US7900836B2 (en) * | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7441703B2 (en) * | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
US7092160B2 (en) * | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
US20100255603A9 (en) * | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
US7985590B2 (en) * | 2002-09-26 | 2011-07-26 | Science Application International Corporation | Method and system for detection using nanodot taggants |
AU2003266932B2 (en) * | 2002-09-27 | 2009-04-09 | Mpm-Holding Aps | Spatially encoded polymer matrix |
US7035308B1 (en) | 2002-10-28 | 2006-04-25 | Science Applications International Corporation | Method and system for countering laser technology |
FR2846445B1 (fr) * | 2002-10-29 | 2005-04-08 | Claude Lambert | Procede d'authentification par marquage ou tracage chimique d'un objet ou d'une substance. |
DE10252628A1 (de) * | 2002-11-11 | 2004-05-19 | Forschungszentrum Jülich GmbH | Verfahren zur Codierung von Informationen sowie Vorrichtung und Verfahren zur Auswertung der codierten Information |
DE20306138U1 (de) | 2003-04-16 | 2003-09-04 | Monajembashi Shamci | Präparat, insbesondere für die Handhabung mittels einer optischen Pinzette |
US7917298B1 (en) | 2003-04-17 | 2011-03-29 | Nanosys, Inc. | Nanocrystal taggants |
US20040259270A1 (en) * | 2003-06-19 | 2004-12-23 | Wolf David E. | System, device and method for exciting a sensor and detecting analyte |
US8796030B2 (en) | 2003-07-12 | 2014-08-05 | Parallel Synthesis Technologies, Inc. | Methods for optically encoding an object with upconverting materials and compositions used therein |
US7538869B2 (en) * | 2004-06-30 | 2009-05-26 | Chemimage Corporation | Multipoint method for identifying hazardous agents |
US20060057729A1 (en) * | 2003-09-12 | 2006-03-16 | Illumina, Inc. | Diffraction grating-based encoded element having a substance disposed thereon |
AU2003285133A1 (en) * | 2003-11-05 | 2005-06-24 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Biofunctionalized quantum dots for biological imaging |
EP1687024B1 (de) * | 2003-11-05 | 2011-10-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Kohlenhydrat-antigen-nanoteilchen-konjugate und ihre verwendungen als antimetastatische mittel bei der behandlung von krebs |
US20050136412A1 (en) * | 2003-12-22 | 2005-06-23 | Affymetrix, Inc. | Light-based detection and manipulation of single molecules |
WO2005062018A2 (en) | 2003-12-22 | 2005-07-07 | Versamatrix A/S | Apparatus and methods for analysis and sorting of particles such as polymer beads |
US7433123B2 (en) * | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
US7202943B2 (en) * | 2004-03-08 | 2007-04-10 | National Research Council Of Canada | Object identification using quantum dots fluorescence allocated on Fraunhofer solar spectral lines |
US7999455B2 (en) * | 2006-11-13 | 2011-08-16 | Research Triangle Institute | Luminescent device including nanofibers and light stimulable particles disposed on a surface of or at least partially within the nanofibers |
US20060019265A1 (en) * | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
US7815854B2 (en) * | 2004-04-30 | 2010-10-19 | Kimberly-Clark Worldwide, Inc. | Electroluminescent illumination source for optical detection systems |
WO2006020363A2 (en) * | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
US7837675B2 (en) | 2004-07-22 | 2010-11-23 | Shaser, Inc. | Method and device for skin treatment with replaceable photosensitive window |
US7566942B2 (en) * | 2004-10-20 | 2009-07-28 | Massachusetts Institute Of Technology | Multi-spectral pixel and focal plane array |
US8927892B2 (en) * | 2004-10-22 | 2015-01-06 | Parallel Synthesis Technologies | Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same |
US7682782B2 (en) * | 2004-10-29 | 2010-03-23 | Affymetrix, Inc. | System, method, and product for multiple wavelength detection using single source excitation |
CA2586197C (en) | 2004-11-04 | 2012-08-14 | Mesophotonics Limited | Metal nano-void photonic crystal for enhanced raman spectroscopy |
DE602005019791D1 (de) * | 2004-11-16 | 2010-04-15 | Illumina Inc | Verfahren und vorrichtung zum lesen von kodierten mikrokugeln |
US7604173B2 (en) * | 2004-11-16 | 2009-10-20 | Illumina, Inc. | Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same |
WO2006055735A2 (en) * | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
US20060134324A1 (en) * | 2004-11-17 | 2006-06-22 | Illumina, Inc. | Filament with easily removed protective coating and methods for stripping the same |
SE0402996D0 (sv) * | 2004-12-09 | 2004-12-09 | Alexander M Grishin | Microwave Readable Ferroelectric Barcode |
JP2008524600A (ja) * | 2004-12-16 | 2008-07-10 | インヴィトロジェン コーポレーション | 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法 |
US7586684B2 (en) * | 2005-01-21 | 2009-09-08 | New York University | Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps |
AU2006214762B2 (en) * | 2005-02-18 | 2010-07-08 | American Dye Source Inc. | Method for encoding materials with a luminescent tag and apparatus for reading same |
US7277169B2 (en) * | 2005-02-18 | 2007-10-02 | The Regents Of The University Of Michigan | Whole spectrum fluorescence detection with ultrafast white light excitation |
US20060229819A1 (en) * | 2005-04-12 | 2006-10-12 | Eastman Kodak Company | Method for imaging an array of microspheres |
US8351026B2 (en) | 2005-04-22 | 2013-01-08 | Affymetrix, Inc. | Methods and devices for reading microarrays |
US20060243809A1 (en) * | 2005-04-27 | 2006-11-02 | Hodgson Rodney T | Combination logo and identification code |
US7238957B2 (en) * | 2005-05-02 | 2007-07-03 | Raytheon Company | Methods and apparatus for presenting images |
WO2006119561A1 (en) * | 2005-05-10 | 2006-11-16 | Commonwealth Scientific And Industrial Research Organisation | High-resolution tracking of industrial process materials using trace incorporation of luminescent markers |
US9297092B2 (en) | 2005-06-05 | 2016-03-29 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
US20060290000A1 (en) * | 2005-06-28 | 2006-12-28 | Wojciech Worwag | Composite metal layer formed using metal nanocrystalline particles in an electroplating bath |
US7227128B2 (en) * | 2005-06-30 | 2007-06-05 | Applera Corporation | System and methods for improving signal/noise ratio for signal detectors |
US7817273B2 (en) * | 2005-06-30 | 2010-10-19 | Life Technologies Corporation | Two-dimensional spectral imaging system |
US7663750B2 (en) | 2005-06-30 | 2010-02-16 | Applied Biosystems, Llc | Two-dimensional spectral imaging system |
WO2007014267A2 (en) * | 2005-07-26 | 2007-02-01 | Oregon Health & Science University | Nanoparticle probes for capture, sorting and placement of targets |
US7871770B2 (en) | 2005-08-09 | 2011-01-18 | Maxwell Sensors, Inc. | Light transmitted assay beads |
US8232092B2 (en) * | 2005-08-09 | 2012-07-31 | Maxwell Sensors, Inc. | Apparatus and method for digital magnetic beads analysis |
US7858307B2 (en) * | 2005-08-09 | 2010-12-28 | Maxwell Sensors, Inc. | Light transmitted assay beads |
US20090201504A1 (en) * | 2005-08-09 | 2009-08-13 | Maxwell Sensors, Inc. | Hydrodynamic focusing for analyzing rectangular microbeads |
WO2007035597A2 (en) * | 2005-09-16 | 2007-03-29 | Hypermed, Inc. | Disposable calibration-fiducial mark for hyperspectral imaging |
US7745788B2 (en) * | 2005-09-23 | 2010-06-29 | Massachusetts Institute Of Technology | Optical trapping with a semiconductor |
US8673107B2 (en) * | 2005-10-28 | 2014-03-18 | Parallel Synthesis Technologies | Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles |
US20090298197A1 (en) * | 2005-11-15 | 2009-12-03 | Oxonica Materials Inc. | Sers-based methods for detection of bioagents |
US7623624B2 (en) * | 2005-11-22 | 2009-11-24 | Illumina, Inc. | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction |
US8409863B2 (en) | 2005-12-14 | 2013-04-02 | Becton, Dickinson And Company | Nanoparticulate chemical sensors using SERS |
JP5537034B2 (ja) | 2005-12-23 | 2014-07-02 | ナノストリング テクノロジーズ,インコーポレーテッド | ナノレポーターならびにその作製方法および使用方法 |
US7723100B2 (en) | 2006-01-13 | 2010-05-25 | Becton, Dickinson And Company | Polymer coated SERS nanotag |
US8835185B2 (en) * | 2006-01-18 | 2014-09-16 | Canon Kabushiki Kaisha | Target substance-detecting element |
US7226752B1 (en) | 2006-01-19 | 2007-06-05 | Avago Technologies General Ip (Singapore) Pte. Ltd. | Methods for detecting an analyte in a sample |
ES2601391T3 (es) * | 2006-01-27 | 2017-02-15 | Becton Dickinson And Company | Inmunoensayo de flujo lateral con modalidad de detección encapsulada |
US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7715001B2 (en) * | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7692783B2 (en) * | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
CA2571904A1 (en) * | 2006-02-15 | 2007-08-15 | Fio Corporation | System and method of detecting pathogens |
US8460879B2 (en) | 2006-02-21 | 2013-06-11 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
US11237171B2 (en) | 2006-02-21 | 2022-02-01 | Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
US7583378B2 (en) * | 2006-02-23 | 2009-09-01 | Itt Manufacturing Enterprises, Inc. | Spectrograph calibration using known light source and Raman scattering |
EP2041478B1 (de) | 2006-03-07 | 2014-08-06 | QD Vision, Inc. | Halbleiternanokristalle enthaltender artikel |
US8849087B2 (en) | 2006-03-07 | 2014-09-30 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
WO2007112088A2 (en) | 2006-03-24 | 2007-10-04 | Qd Vision, Inc. | Hyperspectral imaging device |
WO2007117672A2 (en) | 2006-04-07 | 2007-10-18 | Qd Vision, Inc. | Methods of depositing nanomaterial & methods of making a device |
US7830575B2 (en) * | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
EP2044402B2 (de) * | 2006-07-24 | 2016-11-30 | Becton Dickinson and Company | Vorrichtung und Verfahren zur Durchführung eines Assays mittels magnetischer Partikeln. |
US7764361B2 (en) * | 2006-07-27 | 2010-07-27 | Northwestern University | Systems and methods to analyze multiplexed bead-based assays using backscattered light |
JP2010503866A (ja) * | 2006-09-15 | 2010-02-04 | ヘモネティクス コーポレイション | 官能化された表面に関する粒子の光学的操作による表面マッピング |
US8709789B2 (en) * | 2006-11-20 | 2014-04-29 | Hypromatrix, Inc. | Methods and devices for rapid and specific detection of multiple proteins |
WO2008063652A1 (en) * | 2006-11-21 | 2008-05-29 | Qd Vision, Inc. | Blue emitting semiconductor nanocrystals and compositions and devices including same |
CA2580589C (en) | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
EP2109900A1 (de) * | 2007-01-08 | 2009-10-21 | Plextronics, Inc. | Photovoltaische quantenpunktvorrichtung |
US8836212B2 (en) | 2007-01-11 | 2014-09-16 | Qd Vision, Inc. | Light emissive printed article printed with quantum dot ink |
WO2008095081A2 (en) * | 2007-02-01 | 2008-08-07 | Evident Technologies | Markers comprising light-emitting semiconductor nanocrystals and their use |
GB0702092D0 (en) * | 2007-02-02 | 2007-03-14 | Fracture Code Corp Aps | Graphic Code Application Apparatus and Method |
US20080191027A1 (en) * | 2007-02-12 | 2008-08-14 | San Ming Yang | Semiconductor nanocrystals as marking devices |
US20090024003A1 (en) * | 2007-03-28 | 2009-01-22 | N.V. Organon | Accurate method to assess disease severity in clinical trials concerning psychopathology |
US8360321B2 (en) | 2007-04-02 | 2013-01-29 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
CA2984820C (en) | 2007-04-04 | 2021-12-07 | Ande Corporation | Plastic microfluidic separation and detection platforms |
US8003314B2 (en) | 2007-04-16 | 2011-08-23 | Diagnostic Hybrids, Inc. | Methods for direct fluorescent antibody virus detection in liquids |
US8597729B2 (en) | 2007-06-22 | 2013-12-03 | Fio Corporation | Systems and methods for manufacturing quantum dot-doped polymer microbeads |
US8551786B2 (en) * | 2007-07-09 | 2013-10-08 | Fio Corporation | Systems and methods for enhancing fluorescent detection of target molecules in a test sample |
US20100257027A1 (en) * | 2007-07-23 | 2010-10-07 | Fio Corporation | Method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects |
EP2402725B1 (de) * | 2007-07-31 | 2017-09-27 | Nippon Telegraph And Telephone Corporation | Spektroskop |
US8611619B2 (en) * | 2007-08-22 | 2013-12-17 | Phadia Ab | Read-out method and apparatus |
EP2201374B1 (de) | 2007-08-30 | 2015-10-07 | Trustees Of Tufts College | Verfahren zur bestimmung der konzentration eines analyten in lösung |
WO2009082523A2 (en) * | 2007-09-26 | 2009-07-02 | Massachusetts Institute Of Technology | High-resolution 3d imaging of single semiconductor nanocrystals |
WO2009048833A1 (en) * | 2007-10-09 | 2009-04-16 | Siemens Healthcare Diagnostics Inc. | Two dimensional imaging of reacted areas on a reagent |
EP2209549A4 (de) | 2007-10-12 | 2014-03-05 | Fio Corp | Strömungsfokussierungsverfahren und system zur bildung von konzentrierten volumina von mikrokügelchen und weiterhin gebildete mikrokügelchen |
JP5186176B2 (ja) * | 2007-10-19 | 2013-04-17 | 株式会社ジェーシービー | 認証システム及び認証用可搬媒体 |
US9395534B2 (en) * | 2007-11-27 | 2016-07-19 | Wisconsin Alumni Research Foundation | Optical system for correction of tissue induced aberration |
EP2252229B1 (de) * | 2008-03-11 | 2012-12-05 | Shaser, Inc. | Verbesserung von optischen bestrahlungssystemen zur verwendung bei dermatologischen behandlungen |
JP2011524064A (ja) | 2008-05-06 | 2011-08-25 | キユーデイー・ビジヨン・インコーポレーテツド | 量子閉じ込め半導体ナノ粒子を含有する固体照明装置 |
US9207385B2 (en) | 2008-05-06 | 2015-12-08 | Qd Vision, Inc. | Lighting systems and devices including same |
WO2009137053A1 (en) | 2008-05-06 | 2009-11-12 | Qd Vision, Inc. | Optical components, systems including an optical component, and devices |
WO2010002540A2 (en) | 2008-06-05 | 2010-01-07 | Life Technologies Corporation | Activation and monitoring of cellular transmembrane potentials |
JP4931091B2 (ja) * | 2008-06-06 | 2012-05-16 | Idec株式会社 | 識別情報含有物、情報識別装置及び情報識別方法 |
WO2009155704A1 (en) | 2008-06-25 | 2009-12-30 | Fio Corporation | Bio-threat alert system |
EP2303771B1 (de) * | 2008-06-30 | 2018-05-30 | Life Technologies Corporation | Verfahren zum isolieren und reinigen von nanoteilchen aus einem komplexen medium |
JP5508416B2 (ja) * | 2008-07-24 | 2014-05-28 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | ディスパーシブフーリエ変換イメージングの装置および方法 |
CA2733609C (en) | 2008-08-14 | 2018-03-06 | Nanostring Technologies, Inc. | Stable nanoreporters |
US8446463B2 (en) * | 2008-08-22 | 2013-05-21 | Genprime, Inc. | Apparatus, method and article to perform assays using assay strips |
US20100050793A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Flexible chemical sensors |
CN105759021A (zh) | 2008-08-29 | 2016-07-13 | Fio公司 | 用于检测生物和环境检测样品的一次性手持式诊断检测设备和相关系统与方法 |
RU2578023C2 (ru) | 2009-01-13 | 2016-03-20 | Эф-Ай-Оу Корпорейшн | Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании |
WO2010141105A2 (en) * | 2009-01-23 | 2010-12-09 | Bae Systems Information And Electronic Systems Integration Inc. | Quantum dot-sensory array for biological recognition |
US8886206B2 (en) | 2009-05-01 | 2014-11-11 | Digimarc Corporation | Methods and systems for content processing |
JP2012529908A (ja) | 2009-06-15 | 2012-11-29 | ネットバイオ・インコーポレーテッド | 法医学的dnaの定量化のための改善された方法 |
US9749607B2 (en) | 2009-07-16 | 2017-08-29 | Digimarc Corporation | Coordinated illumination and image signal capture for enhanced signal detection |
CN105713599B (zh) | 2009-08-14 | 2018-09-11 | 三星电子株式会社 | 发光器件、用于发光器件的光学元件、以及方法 |
AU2010292939B2 (en) * | 2009-09-09 | 2014-09-18 | Absolute Software Corporation | Alert for real-time risk of theft or loss |
AU2010306862B2 (en) | 2009-10-13 | 2015-08-27 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
US8524450B2 (en) | 2009-10-30 | 2013-09-03 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
US8889416B2 (en) * | 2010-01-21 | 2014-11-18 | California Institute Of Technology | Methods and devices for micro-isolation, extraction, and/or analysis of microscale components |
CA2785529C (en) | 2010-02-11 | 2019-01-08 | Nanostring Technologies, Inc. | Compositions and methods for the detection of small rnas |
JP4965706B2 (ja) * | 2010-02-26 | 2012-07-04 | Idec株式会社 | 蛍光スペクトルの識別方法 |
US9678068B2 (en) | 2010-03-01 | 2017-06-13 | Quanterix Corporation | Ultra-sensitive detection of molecules using dual detection methods |
US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
EP2542890B1 (de) | 2010-03-01 | 2015-05-06 | Quanterix Corporation | Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln |
US8415171B2 (en) | 2010-03-01 | 2013-04-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
KR20130057451A (ko) * | 2010-06-14 | 2013-05-31 | 트루테그 테크놀로지스, 인코포레이티드 | 식별자를 가진 패키징된 아이템을 생성하기 위한 시스템 |
US8695618B2 (en) | 2010-12-22 | 2014-04-15 | Carnegie Mellon University | 3D chemical pattern control in 2D fluidics devices |
US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
US9758834B2 (en) | 2011-03-28 | 2017-09-12 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
EP2691752A4 (de) * | 2011-03-31 | 2014-09-17 | Gnubio Inc | Skalierbare spektroskopische erkennung und messung |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
WO2012155084A1 (en) | 2011-05-12 | 2012-11-15 | Netbio, Inc. | Methods and compositions for rapid multiplex amplification of str loci |
US8610970B1 (en) * | 2011-08-20 | 2013-12-17 | Darwin Hu | Liquid crystal display (LCD) scanners |
WO2013039883A1 (en) | 2011-09-12 | 2013-03-21 | Abbvie Biotherapeutics Inc. | Artificial nk cells and uses thereof |
WO2013076531A1 (en) * | 2011-11-23 | 2013-05-30 | Nokia Corporation | An apparatus and method comprising a beam splitter |
EP4361606A2 (de) | 2012-02-03 | 2024-05-01 | California Institute of Technology | Signalkodierung und -dekodierung in multiplexierten biochemischen assays |
US9593982B2 (en) | 2012-05-21 | 2017-03-14 | Digimarc Corporation | Sensor-synchronized spectrally-structured-light imaging |
CN104919054A (zh) * | 2012-07-31 | 2015-09-16 | 胡安·卡洛斯·海梅 | 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法 |
EP3901243A1 (de) | 2012-08-03 | 2021-10-27 | California Institute of Technology | Multiplexing und quantifizierung in pcr mit reduzierter hardware und reduzierten anforderungen |
WO2014031902A2 (en) | 2012-08-23 | 2014-02-27 | The Regents Of The University Of California | Spectrally encoded microbeads and methods and devices for making and using same |
CA2889024C (en) | 2012-10-23 | 2018-03-27 | Koc Universitesi | A method and an apparatus for the detection of a tagging material in fluids |
WO2014113502A1 (en) | 2013-01-15 | 2014-07-24 | Quanterix Corporation | Detection of dna or rna using single molecule arrays and other techniques |
EP2950704B1 (de) * | 2013-01-29 | 2017-10-18 | Philips Lighting Holding B.V. | Lichtquelle, leuchte und chirurgische beleuchtungseinheit |
DE102013006545B4 (de) * | 2013-04-16 | 2020-02-27 | Dräger Safety AG & Co. KGaA | Messvorrichtung und Messverfahren für einen Reaktionsträger |
US9621760B2 (en) | 2013-06-07 | 2017-04-11 | Digimarc Corporation | Information coding and decoding in spectral differences |
JP6206871B2 (ja) * | 2013-07-17 | 2017-10-04 | 国立研究開発法人理化学研究所 | 光学顕微鏡システム |
WO2015124942A2 (en) * | 2014-02-20 | 2015-08-27 | Malvern Instruments Limited | Heterogeneous fluid sample characterization |
DE112015002758T5 (de) * | 2014-06-11 | 2017-04-20 | Micromass Uk Limited | Markieren von ADC-Koaleszenz |
WO2016010494A1 (en) | 2014-07-17 | 2016-01-21 | Kuantag Nanoteknolojiler Geliştirme Ve Üretim A.Ş. | A fluorescent substance detection system |
US10113910B2 (en) | 2014-08-26 | 2018-10-30 | Digimarc Corporation | Sensor-synchronized spectrally-structured-light imaging |
US9920315B2 (en) | 2014-10-10 | 2018-03-20 | California Institute Of Technology | Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array |
US9677935B2 (en) * | 2014-11-03 | 2017-06-13 | Trutag Technologies, Inc. | Fabry-perot spectral image measurement |
US9727941B1 (en) | 2014-11-19 | 2017-08-08 | Digimarc Corporation | Optimizing optical scanners for digital watermark detection |
US9867250B1 (en) | 2015-04-20 | 2018-01-09 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence |
US20160371704A1 (en) | 2015-06-18 | 2016-12-22 | Kuantag Nanoteknolojiler Gelistirme Ve Uretim A.S. | Integrated fuel tracking system |
EP3317624B1 (de) | 2015-07-05 | 2019-08-07 | The Whollysee Ltd. | Optisches identifizierungs- und charakterisierungssystem und tags |
SG10202107055SA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
SG10202107053QA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
EP3313573A2 (de) * | 2015-07-22 | 2018-05-02 | The University of North Carolina at Chapel Hill | Fluidische vorrichtungen mit kügelchenvertiefungsgeometrien mit räumlich getrennten kügelchenrückhalte- und -signaldetektionssegmenten sowie zugehörige verfahren |
US10203246B2 (en) * | 2015-11-20 | 2019-02-12 | Verifood, Ltd. | Systems and methods for calibration of a handheld spectrometer |
WO2017218777A1 (en) | 2016-06-17 | 2017-12-21 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
US10347364B2 (en) | 2016-09-14 | 2019-07-09 | International Business Machines Corporation | Encoding data from genetic traits relevant to illness diagnosis and heritage |
US10576475B2 (en) | 2016-09-15 | 2020-03-03 | Genprime, Inc. | Diagnostic assay strip cassette |
WO2018070324A1 (ja) * | 2016-10-13 | 2018-04-19 | 国立研究開発法人産業技術総合研究所 | ナノ粒子評価方法およびナノ粒子観察装置 |
AU2017361521B2 (en) | 2016-11-21 | 2020-08-27 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
US10324041B2 (en) | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
US11047854B2 (en) | 2017-02-06 | 2021-06-29 | Abbott Japan Llc | Methods for reducing noise in signal-generating digital assays |
JP7089719B2 (ja) * | 2017-02-07 | 2022-06-23 | ナノフォトン株式会社 | 分光顕微鏡、及び分光観察方法 |
FR3075926B1 (fr) * | 2017-12-21 | 2021-04-02 | Valeo Vision | Dispositif d’eclairage de vehicule automobile |
WO2019157445A1 (en) | 2018-02-12 | 2019-08-15 | Nanostring Technologies, Inc. | Biomolecular probes and methods of detecting gene and protein expression |
SG11202011274YA (en) | 2018-05-14 | 2020-12-30 | Nanostring Technologies Inc | Chemical compositions and methods of using same |
JP7022670B2 (ja) * | 2018-09-10 | 2022-02-18 | 株式会社日立ハイテク | スペクトル校正装置及びスペクトル校正方法 |
JP7447897B2 (ja) * | 2019-05-30 | 2024-03-12 | ソニーグループ株式会社 | 光学測定装置及び光学測定システム |
CN111474154B (zh) * | 2020-04-27 | 2023-01-17 | 广东博创佳禾科技有限公司 | 一种青枯病菌检测光源激发方法及系统 |
US20230363707A1 (en) * | 2020-09-25 | 2023-11-16 | The Regents Of The University Of California | Devices and related methods for physiological examination |
CN113514446B (zh) * | 2021-05-26 | 2022-11-22 | 哈尔滨工业大学 | 一种用于快速匹配识别sers谱图的方法 |
Family Cites Families (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6603007A (de) * | 1965-03-08 | 1966-09-09 | ||
US3663813A (en) * | 1970-01-19 | 1972-05-16 | American Cyanamid Co | Optical reader for luminescent codes luminescing in different wavelengths |
US3628016A (en) * | 1970-11-27 | 1971-12-14 | Pitney Bowes Alpex | Photoelectric reader for fluorescent ink imprinted coded document |
US4215275A (en) | 1977-12-07 | 1980-07-29 | Luxtron Corporation | Optical temperature measurement technique utilizing phosphors |
US4485308A (en) * | 1982-04-26 | 1984-11-27 | General Electric Company | Photo detection system |
JPS59214725A (ja) | 1983-05-20 | 1984-12-04 | Agency Of Ind Science & Technol | 蒸気圧温度計 |
DK641487A (da) * | 1987-12-07 | 1989-06-08 | Gluetech Aps | Fremgangsmaade til modificering af polymeroverflader |
JPH03279860A (ja) * | 1990-03-29 | 1991-12-11 | Mitsui Petrochem Ind Ltd | 検査方法及び検査試薬 |
US5723218A (en) | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
US5079169A (en) | 1990-05-22 | 1992-01-07 | The Regents Of The Stanford Leland Junior University | Method for optically manipulating polymer filaments |
US5460831A (en) * | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Targeted transfection nanoparticles |
US5495334A (en) * | 1990-07-26 | 1996-02-27 | Research Development Corporation Of Japan | Fourier transform spectroscope with quadrangular common path interferometer |
US5665582A (en) * | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
US5817462A (en) * | 1995-02-21 | 1998-10-06 | Applied Spectral Imaging | Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding |
EP0613585A4 (de) * | 1991-11-22 | 1995-06-21 | Univ California | Halbleitende nanokristalle, die durch selbstzusammengesetzte einzelschichten mit festen anorganischen oberflüchen verbunden sind. |
US5377003A (en) * | 1992-03-06 | 1994-12-27 | The United States Of America As Represented By The Department Of Health And Human Services | Spectroscopic imaging device employing imaging quality spectral filters |
JPH0622798A (ja) * | 1992-07-07 | 1994-02-01 | Hitachi Ltd | 塩基配列決定法 |
GB9220564D0 (en) * | 1992-09-29 | 1992-11-11 | Univ London | The method of rheological investigation |
IL108497A0 (en) * | 1993-02-01 | 1994-05-30 | Seq Ltd | Methods and apparatus for dna sequencing |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
JP3371113B2 (ja) * | 1993-09-08 | 2003-01-27 | 三信工業株式会社 | 縦型多気筒エンジンの燃料供給装置 |
US5462880A (en) | 1993-09-13 | 1995-10-31 | Optical Sensors Incorporated | Ratiometric fluorescence method to measure oxygen |
JP2576027B2 (ja) | 1993-10-20 | 1997-01-29 | カシオ計算機株式会社 | 文書書式の設定方法及び装置 |
US5958782A (en) | 1993-10-21 | 1999-09-28 | Minnesota Mining And Manufacturing Company | Cation-sensing composite structure and compounds for use therein |
US5695928A (en) | 1993-12-10 | 1997-12-09 | Novartis Corporation | Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction |
JPH07227299A (ja) * | 1994-02-14 | 1995-08-29 | Kyoto Daiichi Kagaku:Kk | Dnaの特定塩基配列の検出方法及びその装置 |
US5512745A (en) | 1994-03-09 | 1996-04-30 | Board Of Trustees Of The Leland Stanford Jr. University | Optical trap system and method |
EP0700980B1 (de) * | 1994-03-17 | 1999-11-17 | Hitachi Maxell, Ltd. | PHOSPHOR, PHOSPHORZUSAMMENSETZUNG und FLUORESZENTER MARK-TRÄGER |
US5537000A (en) * | 1994-04-29 | 1996-07-16 | The Regents, University Of California | Electroluminescent devices formed using semiconductor nanocrystals as an electron transport media and method of making such electroluminescent devices |
US5483338A (en) | 1994-05-26 | 1996-01-09 | Martin Marietta Energy Systems, Inc. | Method and apparatus for evaluating structural weakness in polymer matrix composites |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5525798A (en) * | 1994-12-01 | 1996-06-11 | Pitney Bowes Inc. | Bar code scanner for reading a lower layer luminescent invisible ink that is printed below a upper layer luminescent invisible ink |
ATE254965T1 (de) * | 1995-04-25 | 2003-12-15 | Discovery Partners Internation | Fernprogrammierbare matrizen mit speichern und verwendungen davon |
US6352854B1 (en) | 1995-04-25 | 2002-03-05 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
US5631141A (en) * | 1995-05-05 | 1997-05-20 | The Regents Of The University Of California | High resolution biosensor for in-situ microthermometry |
US6017434A (en) * | 1995-05-09 | 2000-01-25 | Curagen Corporation | Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments |
US5776674A (en) * | 1995-06-05 | 1998-07-07 | Seq, Ltd | Chemical biochemical and biological processing in thin films |
US5620857A (en) | 1995-06-07 | 1997-04-15 | United States Of America, As Represented By The Secretary Of Commerce | Optical trap for detection and quantitation of subzeptomolar quantities of analytes |
US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US5756007A (en) * | 1995-11-16 | 1998-05-26 | Lucent Technologies Inc. | Composition for protection of devices |
WO1997035176A1 (en) * | 1996-03-19 | 1997-09-25 | University Of Utah Research Foundation | Lens and associatable flow cell |
US5945526A (en) * | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
EP0920608B1 (de) * | 1996-08-22 | 2005-01-26 | Eastman Chemical Company | On-line qualitative analyse chemischer zusammensetzungen mittels ramanspektrometrie |
US5786219A (en) * | 1996-10-28 | 1998-07-28 | Molecular Probes, Inc. | Microspheres with fluorescent spherical zones |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
US6054325A (en) | 1996-12-02 | 2000-04-25 | Glaxo Wellcom Inc. | Method and apparatus for transferring and combining distinct chemical compositions with reagents |
US5990476A (en) | 1996-12-17 | 1999-11-23 | Physical Electronics Inc | Control of surface potential of insulating specimens in surface analysis |
US5939021A (en) | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
JP4209471B2 (ja) | 1997-02-20 | 2009-01-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プラズモン共鳴粒子、方法、および装置 |
JPH1151935A (ja) * | 1997-08-06 | 1999-02-26 | Aisin Seiki Co Ltd | 複数種類のターゲット分子の同時検出方法 |
US6297018B1 (en) * | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US7348181B2 (en) * | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6055106A (en) | 1998-02-03 | 2000-04-25 | Arch Development Corporation | Apparatus for applying optical gradient forces |
JP3944996B2 (ja) * | 1998-03-05 | 2007-07-18 | 株式会社日立製作所 | Dnaプローブアレー |
US6388788B1 (en) | 1998-03-16 | 2002-05-14 | Praelux, Inc. | Method and apparatus for screening chemical compounds |
US6501091B1 (en) * | 1998-04-01 | 2002-12-31 | Massachusetts Institute Of Technology | Quantum dot white and colored light emitting diodes |
WO1999052708A1 (en) * | 1998-04-13 | 1999-10-21 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
US6384409B1 (en) * | 1998-04-22 | 2002-05-07 | Mqs, Inc. | Optical tracking system |
US6139831A (en) * | 1998-05-28 | 2000-10-31 | The Rockfeller University | Apparatus and method for immobilizing molecules onto a substrate |
ATE423314T1 (de) * | 1998-06-24 | 2009-03-15 | Illumina Inc | Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel |
EP1088229A4 (de) * | 1998-06-25 | 2002-05-08 | Caliper Techn Corp | Hochdurchsatz verfahren, systeme und vorrichtung um zell-basierende screeningassays durchzuführen |
US6159749A (en) * | 1998-07-21 | 2000-12-12 | Beckman Coulter, Inc. | Highly sensitive bead-based multi-analyte assay system using optical tweezers |
JP2002521685A (ja) * | 1998-07-27 | 2002-07-16 | セダーシナイ メディカル センター | 哺乳類の物質のスペクトル・トポグラフィ |
JP2002524845A (ja) | 1998-09-02 | 2002-08-06 | エムイーエムシー・エレクトロニック・マテリアルズ・インコーポレイテッド | 欠陥密度が低い単結晶シリコンから得られるシリコン・オン・インシュレーター構造体 |
IL141759A0 (en) * | 1998-09-03 | 2002-03-10 | Trellis Bioinformatics Inc | Multihued labels |
US6642062B2 (en) * | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
US6821402B1 (en) * | 1998-09-16 | 2004-11-23 | Applera Corporation | Spectral calibration of fluorescent polynucleotide separation apparatus |
US6326144B1 (en) * | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6251303B1 (en) * | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
EP1116036B1 (de) * | 1998-09-18 | 2004-08-11 | Massachusetts Institute Of Technology | Wasserlösliche fluoreszierende halbleiternanokristalle |
EP0990903B1 (de) | 1998-09-18 | 2003-03-12 | Massachusetts Institute Of Technology | Biologische Verwendungen von halbleitenden Nanokristallen |
US6617583B1 (en) | 1998-09-18 | 2003-09-09 | Massachusetts Institute Of Technology | Inventory control |
US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
ATE389030T1 (de) | 1998-09-24 | 2008-03-15 | Univ Indiana Res & Tech Corp | Wasserlösliche lumineszente quantum-dots sowie deren biokonjugate |
SE9903407L (sv) | 1998-09-26 | 2000-03-27 | Kijang Medical Co | Metod för framställning av farmaceutiska artemisia-extrakt samt apparat för elektrisk moxabränning med användande av extraktet |
US6309701B1 (en) * | 1998-11-10 | 2001-10-30 | Bio-Pixels Ltd. | Fluorescent nanocrystal-labeled microspheres for fluorescence analyses |
US6333110B1 (en) * | 1998-11-10 | 2001-12-25 | Bio-Pixels Ltd. | Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging |
AU1717600A (en) * | 1998-11-10 | 2000-05-29 | Biocrystal Limited | Methods for identification and verification |
US6274873B1 (en) * | 1998-11-18 | 2001-08-14 | Dna Technologies Inc. | Spectrum analyzer for reading authentication marks |
US6255116B1 (en) * | 1998-12-17 | 2001-07-03 | Smithkline Beecham Corporation | Apparatus and process for arraying beads |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
US6263104B1 (en) * | 1998-12-31 | 2001-07-17 | Mcgrew Stephen P. | Method and apparatus for reading and verifying holograms |
ATE556149T1 (de) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
US6294343B1 (en) * | 1999-11-09 | 2001-09-25 | Eos Biotechnology, Inc. | Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators |
US6235540B1 (en) | 1999-03-30 | 2001-05-22 | Coulter International Corp. | Semiconductor nanoparticles for analysis of blood cell populations and methods of making same |
EP1175505A4 (de) * | 1999-04-15 | 2005-04-20 | Vitra Bioscience Inc | Kombinatorische vorlage für chemische bibliotheken mit indizes und kodierungspositionen sowie verfahren zur anwendung |
US6284465B1 (en) * | 1999-04-15 | 2001-09-04 | Agilent Technologies, Inc. | Apparatus, systems and method for locating nucleic acids bound to surfaces |
WO2000065094A2 (en) * | 1999-04-22 | 2000-11-02 | The Albert Einstein College Of Medicine Of Yeshiva University | Assay of gene expression patterns by multi-fluor fish |
US20010055764A1 (en) * | 1999-05-07 | 2001-12-27 | Empedocles Stephen A. | Microarray methods utilizing semiconductor nanocrystals |
ATE439452T1 (de) | 1999-05-07 | 2009-08-15 | Life Technologies Corp | Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen |
US6544732B1 (en) * | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
AU6779200A (en) | 1999-08-17 | 2001-03-13 | Luminex Corporation | Encapsulation of fluorescent particles |
US6358684B1 (en) * | 1999-08-27 | 2002-03-19 | Pe Corporation | UV excitable fluorescent energy transfer dyes |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
US6252664B1 (en) * | 1999-10-15 | 2001-06-26 | Biocrystal Ltd. | Fluorescence filter cube for fluorescence detection and imaging |
US20050069956A1 (en) * | 1999-11-22 | 2005-03-31 | Michael Seul | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds |
US6225198B1 (en) | 2000-02-04 | 2001-05-01 | The Regents Of The University Of California | Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process |
US7361488B2 (en) | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
US20020004246A1 (en) * | 2000-02-07 | 2002-01-10 | Daniels Robert H. | Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels |
US6770441B2 (en) * | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
WO2001061040A1 (en) * | 2000-02-16 | 2001-08-23 | Quantum Dot Corporation | Microarray methods utilizing semiconductor nanocrystals |
AU2001238447A1 (en) * | 2000-02-16 | 2001-08-27 | Quantum Dot Corporation | Single target counting assays using semiconductor nanocrystals |
US20020028457A1 (en) * | 2000-02-16 | 2002-03-07 | Quantum Dot Corporation | Single target counting assays using semiconductor nanocrystals |
US20030099940A1 (en) | 2000-02-16 | 2003-05-29 | Empedocles Stephen A. | Single target counting assays using semiconductor nanocrystals |
WO2001063284A2 (en) | 2000-02-25 | 2001-08-30 | Luminex Corporation | Internal standards and controls for multiplexed assay |
CA2403708A1 (en) | 2000-03-22 | 2001-09-27 | Quantum Dot Corporation | Methods of using semiconductor nanocrystals in bead-based nucleic acid assays |
US20020090650A1 (en) * | 2000-04-06 | 2002-07-11 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
US6734420B2 (en) | 2000-04-06 | 2004-05-11 | Quantum Dot Corporation | Differentiable spectral bar code methods and systems |
US7892854B2 (en) | 2000-06-21 | 2011-02-22 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
US20030148544A1 (en) | 2001-06-28 | 2003-08-07 | Advanced Research And Technology Institute, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
WO2003092043A2 (en) | 2001-07-20 | 2003-11-06 | Quantum Dot Corporation | Luminescent nanoparticles and methods for their preparation |
US7041453B2 (en) | 2002-08-22 | 2006-05-09 | Bioarray Solutions Ltd. | Molecular constructs and methods of use for detection of biochemical reactions |
CA2500761C (en) | 2002-10-15 | 2012-11-20 | Bernhard O. Palsson | Methods and systems to identify operational reaction pathways |
JP2008524600A (ja) | 2004-12-16 | 2008-07-10 | インヴィトロジェン コーポレーション | 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法 |
US8360321B2 (en) | 2007-04-02 | 2013-01-29 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
US7799558B1 (en) | 2007-05-22 | 2010-09-21 | Dultz Shane C | Ligand binding assays on microarrays in closed multiwell plates |
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2001
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- 2001-04-06 AT AT01923207T patent/ATE490464T1/de not_active IP Right Cessation
- 2001-04-06 WO PCT/US2001/011391 patent/WO2001077391A1/en active Application Filing
- 2001-04-06 EP EP10180073.8A patent/EP2267451B1/de not_active Expired - Lifetime
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- 2001-04-06 EP EP01928376A patent/EP1282734B1/de not_active Expired - Lifetime
- 2001-04-06 AT AT01928376T patent/ATE535808T1/de active
- 2001-04-06 EP EP20100177052 patent/EP2293066A1/de not_active Ceased
- 2001-04-06 DK DK10180073.8T patent/DK2267451T3/da active
- 2001-04-06 AU AU2001255240A patent/AU2001255240A1/en not_active Abandoned
- 2001-04-06 JP JP2001575029A patent/JP5081359B2/ja not_active Expired - Fee Related
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- 2001-04-06 WO PCT/US2001/011251 patent/WO2001078288A2/en active Application Filing
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- 2001-04-06 JP JP2001574483A patent/JP2004500669A/ja active Pending
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