DE60123583D1 - Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome - Google Patents
Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposomeInfo
- Publication number
- DE60123583D1 DE60123583D1 DE60123583T DE60123583T DE60123583D1 DE 60123583 D1 DE60123583 D1 DE 60123583D1 DE 60123583 T DE60123583 T DE 60123583T DE 60123583 T DE60123583 T DE 60123583T DE 60123583 D1 DE60123583 D1 DE 60123583D1
- Authority
- DE
- Germany
- Prior art keywords
- sugar
- lipid
- liposome
- rehydratisation
- dehydratisation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00300904 | 2000-02-04 | ||
EP00300904 | 2000-02-04 | ||
PCT/GB2001/000391 WO2001056548A2 (en) | 2000-02-04 | 2001-01-31 | Liposomes composition produced by a dehydration-rehydration process |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60123583D1 true DE60123583D1 (de) | 2006-11-16 |
DE60123583T2 DE60123583T2 (de) | 2007-08-09 |
Family
ID=8172682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60123583T Expired - Lifetime DE60123583T2 (de) | 2000-02-04 | 2001-01-31 | Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome |
Country Status (8)
Country | Link |
---|---|
US (1) | US7025988B2 (de) |
EP (1) | EP1259225B1 (de) |
JP (1) | JP4786105B2 (de) |
AT (1) | ATE341310T1 (de) |
AU (1) | AU2869901A (de) |
DE (1) | DE60123583T2 (de) |
ES (1) | ES2272496T3 (de) |
WO (1) | WO2001056548A2 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005502653A (ja) * | 2001-08-20 | 2005-01-27 | トランセーヴ・インコーポレーテッド | 肺ガンの治療方法 |
PT1509256E (pt) | 2002-05-24 | 2009-10-15 | Angiotech Int Ag | Composições e métodos de revestimento de implantes médicos |
CA2491216C (en) | 2002-06-26 | 2012-01-03 | Medigene Oncology Gmbh | Method of producing a cationic liposomal preparation comprising a lipophilic compound |
EP1519745B1 (de) | 2002-07-05 | 2006-12-20 | Lipoxen Technologies Limited | Verfahren zur verstärkung einer immunantwort von nukleinsäureimpfungen |
US9186322B2 (en) * | 2002-08-02 | 2015-11-17 | Insmed Incorporated | Platinum aggregates and process for producing the same |
KR20050038011A (ko) * | 2002-08-02 | 2005-04-25 | 트랜세이브, 인코포레이티드 | 백금 응집체 및 이의 제조 방법 |
CN100518831C (zh) * | 2002-08-15 | 2009-07-29 | 刘云清 | 固体纳米药物及其制备方法 |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
BRPI0407415A (pt) * | 2003-02-11 | 2006-01-10 | Neopharm Inc | Método de fabricar um preparado lipossÈmico |
JP2007522085A (ja) * | 2003-06-27 | 2007-08-09 | スミスクライン・ビーチャム・コーポレイション | 安定化されたトポテカンリポソーム組成物および方法 |
US20050048109A1 (en) * | 2003-08-26 | 2005-03-03 | Ceramoptec Industries, Inc. | Non-polar photosensitizer formulations for photodynamic therapy |
EP1729786A4 (de) * | 2004-03-18 | 2008-03-26 | Transave Inc | Verabreichung von cisplatin durch inhalation |
US20070065522A1 (en) * | 2004-03-18 | 2007-03-22 | Transave, Inc. | Administration of high potency platinum compound formulations by inhalation |
KR101462825B1 (ko) | 2004-05-03 | 2014-11-21 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
WO2005112957A1 (en) * | 2004-05-21 | 2005-12-01 | Transave, Inc. | Treatment of lung diseases and pre-lung disease conditions |
US20050281799A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
KR20070089693A (ko) * | 2004-11-08 | 2007-08-31 | 트랜세이브, 인코포레이티드 | 지질-기재 플래티넘 화합물 제형을 복막내 투여하여 암을치료하는 방법 |
JP5303269B2 (ja) | 2005-06-06 | 2013-10-02 | 学校法人早稲田大学 | 骨髄指向性薬物送達物質およびその用途 |
TWI291237B (en) * | 2005-10-07 | 2007-12-11 | Integrated Digital Technologie | Photo detector array |
WO2007056236A2 (en) * | 2005-11-08 | 2007-05-18 | Transave, Inc. | Methods of treating cancer with lipid-based platinum compound formulations administered intravenously |
US9107824B2 (en) | 2005-11-08 | 2015-08-18 | Insmed Incorporated | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
WO2007056264A2 (en) * | 2005-11-08 | 2007-05-18 | Transave, Inc. | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
PL1962805T3 (pl) | 2005-12-08 | 2017-01-31 | Insmed Incorporated | Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych |
ES2668554T3 (es) * | 2006-04-06 | 2018-05-18 | Insmed Incorporated | Métodos para la encapsulación liposomal inducida por coacervación y sus formulaciones |
WO2008036763A2 (en) * | 2006-09-20 | 2008-03-27 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
CA2734284C (en) * | 2008-11-20 | 2014-01-21 | Techno Guard Co., Ltd. | Pyrazolone derivative formulations |
US8591942B2 (en) * | 2009-09-23 | 2013-11-26 | Indu JAVERI | Methods for the preparation of liposomes comprising docetaxel |
US20110070294A1 (en) * | 2009-09-23 | 2011-03-24 | Javeri Indu | Methods for the Administration of Drugs Using Liposomes |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
EP2394640A1 (de) * | 2010-05-21 | 2011-12-14 | MediGene AG | Verbesserte liposomale Formulierungen von lipophilen Verbindungen |
JP6402097B2 (ja) | 2012-05-21 | 2018-10-10 | インスメッド インコーポレイテッド | 肺感染症を処置するためのシステム |
US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
EP2682106A1 (de) | 2012-07-03 | 2014-01-08 | Phares Pharmaceutical Research N.V. | Verfahren zum Auflösen biologisch aktiver Verbindungen |
WO2014034669A1 (ja) * | 2012-08-28 | 2014-03-06 | 国立大学法人北海道大学 | 非極性溶媒に分散性を有する細菌菌体成分を内封する脂質膜構造体およびその製造方法 |
JP2015530387A (ja) | 2012-09-04 | 2015-10-15 | エライゾン ファーマシューティカルズ, エルエルシー | 脂質複合体化シスプラチンによる肺癌の再発防止 |
ES2743039T3 (es) | 2012-11-29 | 2020-02-18 | Insmed Inc | Formulaciones de vancomicina estabilizada |
US10238675B2 (en) | 2014-05-15 | 2019-03-26 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
RU2760185C2 (ru) | 2015-08-20 | 2021-11-22 | Ипсен Биофарм Лтд. | Комбинированная терапия с применением липосомального иринотекана и ингибитора parp для лечения рака |
WO2017034957A1 (en) | 2015-08-21 | 2017-03-02 | Merrimack Pharmaceuticals, Inc. | Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin |
EP3362049A1 (de) | 2015-10-16 | 2018-08-22 | Ipsen Biopharm Ltd. | Stabilisierung von pharmazeutischen camptothecinzusammensetzungen |
CN106924195B (zh) * | 2015-12-31 | 2020-11-13 | 南京绿叶制药有限公司 | 一种注射用紫杉醇脂质体组合物的冻干工艺 |
MY198105A (en) * | 2016-01-07 | 2023-08-02 | Univ Western Health Sciences | Formulations for treating bladder cancer |
AU2017351900B2 (en) * | 2016-10-31 | 2020-11-26 | Eyegene Inc. | Composition for enhancing immunity comprising immune modulator and cationic liposome, and use of same |
SG10201912338RA (en) | 2016-11-02 | 2020-02-27 | Ipsen Biopharm Ltd | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
US4885172A (en) * | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
FR2593394A1 (fr) * | 1986-01-30 | 1987-07-31 | Ire Celltarg Sa | Procede de preparation de liposomes contenant une subtance active lipophile, notamment de l'amphotericine, liposomes et nouveau medicament obtenus |
AU6833994A (en) * | 1993-05-17 | 1994-12-12 | Liposome Company, Inc., The | Incorporation of taxol into liposomes and gels |
GB9320668D0 (en) * | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
DE4432378A1 (de) | 1994-09-12 | 1996-03-14 | Bayer Ag | Injizierbare liposomale Arzneizubereitungen |
EP0792143B1 (de) * | 1994-11-18 | 2002-09-04 | Aphios Corporation | Verfahren zur Herstellung von Liposomen, die hydrophobische Artzneistoffe enthalten |
GB9813100D0 (en) | 1998-06-18 | 1998-08-19 | Secr Defence | Method of forming liposomes |
US6146659A (en) * | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
-
2001
- 2001-01-31 US US10/182,921 patent/US7025988B2/en not_active Expired - Fee Related
- 2001-01-31 ES ES01948934T patent/ES2272496T3/es not_active Expired - Lifetime
- 2001-01-31 AT AT01948934T patent/ATE341310T1/de not_active IP Right Cessation
- 2001-01-31 EP EP01948934A patent/EP1259225B1/de not_active Expired - Lifetime
- 2001-01-31 JP JP2001556240A patent/JP4786105B2/ja not_active Expired - Fee Related
- 2001-01-31 DE DE60123583T patent/DE60123583T2/de not_active Expired - Lifetime
- 2001-01-31 WO PCT/GB2001/000391 patent/WO2001056548A2/en active IP Right Grant
- 2001-01-31 AU AU28699/01A patent/AU2869901A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60123583T2 (de) | 2007-08-09 |
AU2869901A (en) | 2001-08-14 |
JP4786105B2 (ja) | 2011-10-05 |
ATE341310T1 (de) | 2006-10-15 |
ES2272496T3 (es) | 2007-05-01 |
US7025988B2 (en) | 2006-04-11 |
JP2003521508A (ja) | 2003-07-15 |
US20030138481A1 (en) | 2003-07-24 |
WO2001056548A2 (en) | 2001-08-09 |
EP1259225B1 (de) | 2006-10-04 |
WO2001056548A3 (en) | 2002-03-21 |
EP1259225A2 (de) | 2002-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |