DE60041072D1 - Em nachweis - Google Patents

Em nachweis

Info

Publication number
DE60041072D1
DE60041072D1 DE60041072T DE60041072T DE60041072D1 DE 60041072 D1 DE60041072 D1 DE 60041072D1 DE 60041072 T DE60041072 T DE 60041072T DE 60041072 T DE60041072 T DE 60041072T DE 60041072 D1 DE60041072 D1 DE 60041072D1
Authority
DE
Germany
Prior art keywords
proof
snps
mismatches
compositions
self
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041072T
Other languages
English (en)
Inventor
Robert M Umek
Gary Blackburn
Bruce D Irvine
Robert H Terbrueggen
Changjun Yu
Jost G Vielmetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Micro Sensors Inc
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Application granted granted Critical
Publication of DE60041072D1 publication Critical patent/DE60041072D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
DE60041072T 1999-07-26 2000-07-26 Em nachweis Expired - Lifetime DE60041072D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14569599P 1999-07-26 1999-07-26
US19025900P 2000-03-17 2000-03-17
PCT/US2000/020476 WO2001007665A2 (en) 1999-07-26 2000-07-26 Sequence determination of nucleic acids using electronic detection

Publications (1)

Publication Number Publication Date
DE60041072D1 true DE60041072D1 (de) 2009-01-22

Family

ID=26843217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041072T Expired - Lifetime DE60041072D1 (de) 1999-07-26 2000-07-26 Em nachweis

Country Status (9)

Country Link
US (1) US7935481B1 (de)
EP (1) EP1218541B1 (de)
JP (1) JP3926625B2 (de)
AT (1) ATE417127T1 (de)
AU (1) AU779220B2 (de)
CA (1) CA2380258C (de)
DE (1) DE60041072D1 (de)
ES (1) ES2319380T3 (de)
WO (1) WO2001007665A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1241000A (en) 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
US6986992B2 (en) 2001-03-30 2006-01-17 Amersham Biosciences Ab P450 single nucleotide polymorphism biochip analysis
EP1527194A4 (de) * 2001-04-03 2005-07-20 Clinical Micro Sensors Inc Nukleinsäurereaktionen unter verwendung von markierungen mit unterschiedlichen redoxpotentialen
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
WO2003018834A2 (de) 2001-08-25 2003-03-06 Friz Biochem Gmbh Verdrängungsassay zur detektion von nukleinsäureoligomer-hybridisierungsereignissen
DE10141691A1 (de) * 2001-08-25 2003-03-13 Friz Biochem Gmbh Verdrängungsassay zur Detektion von Ligat-Ligand-Assoziationsereignissen
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
DE10261528B4 (de) * 2002-12-23 2006-10-05 Friz Biochem Gesellschaft Für Bioanalytik Mbh Elektrisches Substrat zum Einsatz als Träger von Biomolekülen
MXPA05011909A (es) 2003-05-02 2006-09-04 Ct Biolog Medycznej I Mikrobio Derivado de nucleosido, oligonucleotido modificado, metodo para su sintesis y aplicaciones de los mismos.
EP1859330B1 (de) 2005-01-28 2012-07-04 Duke University Vorrichtungen und verfahren zur manipulation von tropfen auf einer leiterplatte
CA2672315A1 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
AT505495A1 (de) * 2007-07-04 2009-01-15 Arc Austrian Res Centers Gmbh Verfahren zur identifizierung und quantifizierung von organischen und biochemischen substanzen
TWI421492B (zh) * 2007-09-28 2014-01-01 Hitachi Chemical Co Ltd 金屬離子感測器、金屬離子感測器系統以及攜帶式金屬離子感測器系統
KR100799593B1 (ko) 2007-10-08 2008-01-30 한국전자통신연구원 비대칭 디설파이드 정착기를 가지는 분자 전자소자용화합물 및 그 제조 방법과 그 화합물로부터 얻어지는 분자활성층을 가지는 분자 전자소자
KR100819059B1 (ko) * 2007-10-08 2008-04-03 한국전자통신연구원 비대칭 디설파이드 정착기를 가지는 분자 전자소자용화합물 및 그 제조 방법과 그 화합물로부터 얻어지는 분자활성층을 가지는 분자 전자소자
CA2740414A1 (en) * 2008-10-14 2010-04-22 Bioaccel System and method for inferring str allelic genotype from snps
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010047804A1 (en) * 2008-10-22 2010-04-29 Ion Torrent Systems Incorporated Integrated sensor arrays for biological and chemical analysis
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
CA2889415C (en) 2012-10-24 2020-06-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
EP3034171B1 (de) 2013-03-15 2019-04-24 Genmark Diagnostics Inc. Systeme, verfahren und vorrichtung zur manipulation verformbarer flüssigkeitsgefässe
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
JP2018502309A (ja) 2014-11-11 2018-01-25 ジェンマーク ダイアグノスティクス， インコーポレイテッド 閉止サンプル調製・反応システムにおいて、アッセイを実行するための装置及びカートリッジ
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
WO2019040769A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS
WO2023237641A1 (en) * 2022-06-07 2023-12-14 F. Hoffmann-La Roche Ag Ferrocene labelled primers for electrochemical detection

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US5509410A (en) 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
GB8328520D0 (en) 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
DE3479522D1 (en) 1983-12-16 1989-09-28 Medisense Inc Assay for nucleic acids
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US5002885A (en) 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
GB8417301D0 (en) 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4713347A (en) 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US5112974A (en) 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
GB8507706D0 (en) 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4876187A (en) 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (en) 1986-02-27 1989-05-30 Marco F. Cardosi Application of tetrathiafulvalenes in bioelectrochemical processes
US4704193A (en) 1986-05-14 1987-11-03 Gte Laboratories Incorporated Covalently coupled cofactor modified electrodes and methods of synthesis and use
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US5175270A (en) 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
ZA877772B (en) 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US4787963A (en) 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
FI80476C (fi) 1987-10-09 1990-06-11 Orion Yhtymae Oy Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning.
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
IL92474A (en) 1988-11-29 1994-04-12 Orion Yhtymae Oy Reaction method and combination for determining nucleotide sequences
US5089112A (en) 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5015569A (en) 1989-12-01 1991-05-14 Board Of Trustees Of Leland Stanford University Acceleration of nucleic acid hybridization
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
EP0478319B1 (de) 1990-09-28 1997-04-02 Kabushiki Kaisha Toshiba Verfahren zum Gennachweis
DE4039677A1 (de) 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5180968A (en) 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5171853A (en) 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
JP3509859B2 (ja) 1991-11-07 2004-03-22 ナノトロニクス，インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
CA2100159C (en) 1991-11-15 2003-01-21 John R. Link Rapid assays for amplification products
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
EP0566751B1 (de) 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag Verfahren zum DNS-Nachweis
GB9210176D0 (en) 1992-05-12 1992-06-24 Cemu Bioteknik Ab Chemical method
GB9212010D0 (en) 1992-06-05 1992-07-15 Medisense Inc Mediators to oxidoreductase enzymes
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
IL102930A (en) 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
US5633134A (en) * 1992-10-06 1997-05-27 Ig Laboratories, Inc. Method for simultaneously detecting multiple mutations in a DNA sample
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
EP0599337B1 (de) 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Verfahren und Sonde zum Nachweis von Nukleinsäuren
US5244560A (en) 1992-12-29 1993-09-14 The Regents Of The University Of California Method of fabrication for capillary electrophoresis and electrochemical detector for the same
JPH08505476A (ja) 1993-03-05 1996-06-11 ユニヴァーシティー オブ ウーロンゴング 電気的に活性なポリマ電極を用いたパルス式電気化学的検出方法
FR2703359B1 (fr) 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
AU7208394A (en) 1993-06-17 1995-01-17 Research Foundation Of The State University Of New York, The Improved nucleic acid reactions
JPH09502084A (ja) 1993-06-17 1997-03-04 アイディー バイオメディカル コーポレイション 核酸配列検出の改良方法
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
AU7487294A (en) 1993-08-18 1995-03-14 Id Biomedical Corporation Compositions and methods for detecting target nucleic acid sequences utilizing flanking sequence enzyme molecules
AU7839594A (en) 1993-09-20 1995-04-10 Regents Of The University Of Colorado, The Strategy for the production of rna from immobilized templates
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
IL108726A (en) 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
US5871918A (en) 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
FR2720832A1 (fr) 1994-04-22 1995-12-08 Francis Garnier Electrodes et membranes électroactives à base de peptides bioactifs, pour la reconnaissance, l'extraction ou le relargage d'espèces biologiquement actives.
SE9402116D0 (sv) 1994-06-15 1994-06-15 Pharmacia Biosensor Ab A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate
GB9417211D0 (en) 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
EP0777741A4 (de) 1994-08-26 1999-01-13 Igen Inc Verfahren zum nachweis von auf einer festen oberfläche adsorbierter nukleinsäure durch elektrogenerierte chemilumineszenz und biosensor dafür
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US6066448A (en) 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
DE19515552A1 (de) 1995-04-27 1996-10-31 Europ Lab Molekularbiolog Simultane Sequenzierung von Nukleinsäuren
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
CA2225935A1 (en) 1995-06-27 1997-01-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US5747255A (en) 1995-09-29 1998-05-05 Lynx Therapeutics, Inc. Polynucleotide detection by isothermal amplification using cleavable oligonucleotides
DE19536858C2 (de) 1995-10-03 2000-04-13 Danfoss As Verfahren und Vorrichtung zum Transport eines Fluids durch einen Kanal
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5830341A (en) 1996-01-23 1998-11-03 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5795453A (en) 1996-01-23 1998-08-18 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5861247A (en) 1996-01-26 1999-01-19 University Of Chicago Rapid method to detect duplex formation in sequencing by hybridization methods
US5851772A (en) 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
AU711861B2 (en) 1996-04-25 1999-10-21 Mcgill University Biosensor device and method
US6107080A (en) 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
ES2287956T3 (es) 1996-07-29 2007-12-16 Nanosphere Inc. Nanoparticulas que tienen oligonucleotidos unidos a las mismas y usos de las mismas.
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
EP0939762A2 (de) * 1996-11-05 1999-09-08 Clinical Micro Sensors Elektrode die durch leitende oligomere zur nukleinsäuren gebunden sind
US5942397A (en) 1996-12-11 1999-08-24 Tarlov; Michael J. Surface immobilization of biopolymers
WO1998028444A2 (en) 1996-12-23 1998-07-02 The University Of Chicago Customized oligonucleotide microchips as multiple biosensors
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US20020012943A1 (en) 1997-02-06 2002-01-31 Dana M. Fowlkes Electrochemical probes for detection of molecular interactions and drug discovery
WO1998049344A1 (en) 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
EP0981647B1 (de) 1997-05-16 2006-08-09 EXACT Sciences Corporation Elektrophoretische analyse von molekülen mit immobilisierten sonden
AU7833098A (en) 1997-06-10 1998-12-30 Beaird, Chyle E. Multiple access computer monitoring system
JP4124830B2 (ja) 1997-06-12 2008-07-23 クリニカル・マイクロ・センサーズ・インコーポレイテッド 分析物の検出のための電気的方法
AU9476298A (en) 1997-09-11 1999-03-29 Seq, Ltd. Method for dna sequencing analysis
SE9703314D0 (sv) 1997-09-15 1997-09-15 Sangtec Medical Ab Capacity affinity sensor
DE19741716A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
US5945286A (en) 1997-10-23 1999-08-31 Motorola, Inc. Electrochemical-based molecular detection apparatus and method
US6203758B1 (en) 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
CA2319170A1 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6060023A (en) 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
EP1075541A1 (de) * 1998-05-06 2001-02-14 Clinical Micro Sensors Elektronische detektion von nukleinsäuren unter verwendung von monoschichten
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6361671B1 (en) 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

Also Published As

Publication number Publication date
ES2319380T3 (es) 2009-05-07
WO2001007665A9 (en) 2002-07-11
US7935481B1 (en) 2011-05-03
JP3926625B2 (ja) 2007-06-06
CA2380258A1 (en) 2001-02-01
EP1218541B1 (de) 2008-12-10
AU779220B2 (en) 2005-01-13
WO2001007665A2 (en) 2001-02-01
WO2001007665A3 (en) 2002-05-02
ATE417127T1 (de) 2008-12-15
CA2380258C (en) 2008-07-15
EP1218541A2 (de) 2002-07-03
JP2004500033A (ja) 2004-01-08
AU6610400A (en) 2001-02-13

Similar Documents

Publication Publication Date Title
DE60041072D1 (de) Em nachweis
DK1178999T3 (da) L-RIBO-LNA-analoger
WO2005044836A3 (de) Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
BR0016380B1 (pt) complexo metálico, processo de hidrossililação de olefinas ou de derivados acetilênicos e composição catalìtica.
WO1999054326A8 (de) Dihydropyrimidine
WO2003097794A3 (en) Universal-tagged oligonucleotide primers and methods of use
AU2002351193A8 (en) Parallel polymorphism scoring by amplification and error correction
AU2001238030A1 (en) Detection of single nucleotide polymorphisms
BR9915938A (pt) Derivados de pirimidina substituìdos por arila e heterociclila como anticoagulantes
ATE263157T1 (de) Nematizide trifluorbutene
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2004042351A3 (en) Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
BRPI0409048A (pt) composição curável, composição de revestimento, método de produção de revestimento sobre um substrato e método de produção de sistema de multiplos revestimentos
WO2004041777A3 (en) Heteroarylpiperidine modulators of chemokine receptor activity
WO2004003220A3 (en) Methods and composition for analyzing compromised samples using snps
DE602004031115D1 (de) Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
AU2003246713A1 (en) Hardening and drying of lacquer systems and printing colors
AU2001259131A1 (en) Detection of nucleotide sequence variations via the proofreading activity of polymerases
DE50201565D1 (de) 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie
ATE468408T1 (de) Selektive elution von immobilisierten multiplexierten primerverlängerungsprodukten
HK1066222A1 (en) Mannitol and glucitol derivatives
AU4515699A (en) Tagging of rna amplicons generated by transcription-based amplification
DK1664102T3 (da) Isoleret photoprotein mtclytin, samt dets anvendelse
AU2003245663A1 (en) Process for the enzymatic resolution of 1,3-dioxolane-4-carboxylates

Legal Events

Date Code Title Description
8364 No opposition during term of opposition