DE60040156D1 - Vorrichtung zur elektroporation von genen, proteinen oder zur verabreichung von medikamenten - Google Patents

Vorrichtung zur elektroporation von genen, proteinen oder zur verabreichung von medikamenten

Info

Publication number
DE60040156D1
DE60040156D1 DE60040156T DE60040156T DE60040156D1 DE 60040156 D1 DE60040156 D1 DE 60040156D1 DE 60040156 T DE60040156 T DE 60040156T DE 60040156 T DE60040156 T DE 60040156T DE 60040156 D1 DE60040156 D1 DE 60040156D1
Authority
DE
Germany
Prior art keywords
electroporation
gene
protein
array
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60040156T
Other languages
English (en)
Inventor
Luyi Sen
Guanggen Cui
Jack W Judy
Hillel Laks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE60040156D1 publication Critical patent/DE60040156D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
DE60040156T 1999-04-16 2000-04-17 Vorrichtung zur elektroporation von genen, proteinen oder zur verabreichung von medikamenten Expired - Fee Related DE60040156D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12981799P 1999-04-16 1999-04-16
PCT/US2000/010337 WO2000062855A1 (en) 1999-04-16 2000-04-17 Apparatus for electroporation of gene, protein, or drug therapy

Publications (1)

Publication Number Publication Date
DE60040156D1 true DE60040156D1 (de) 2008-10-16

Family

ID=22441736

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60040156T Expired - Fee Related DE60040156D1 (de) 1999-04-16 2000-04-17 Vorrichtung zur elektroporation von genen, proteinen oder zur verabreichung von medikamenten

Country Status (6)

Country Link
US (1) US6593130B1 (de)
EP (1) EP1210144B1 (de)
AT (1) ATE406936T1 (de)
AU (1) AU4465600A (de)
DE (1) DE60040156D1 (de)
WO (1) WO2000062855A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US7729756B2 (en) * 2000-01-18 2010-06-01 Siemens Aktiengesellschaft Measurement system for examining a section of tissue on a patient and the use of a measurement system of this type
US8263756B2 (en) * 2001-04-06 2012-09-11 Chugai Seiyaku Kabushiki Kaisha Method of gene transfer via vascular system or ureter
AU2002220061A1 (en) * 2001-11-29 2003-06-17 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US7104985B2 (en) * 2003-03-06 2006-09-12 Martinelli Michael A Apparatus and method for causing selective necrosis of abnormal cells
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
CA2527869A1 (en) 2003-05-30 2004-12-23 University Of South Florida Method for the treatment of malignancies
US8802643B1 (en) 2003-05-30 2014-08-12 University Of South Florida Method for the treatment of malignancies
WO2006085987A2 (en) * 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7776373B2 (en) * 2004-11-19 2010-08-17 Eteka Llc Apparatus and method for the enhancement of food properties and food prepared therefrom
US8101169B2 (en) * 2005-02-23 2012-01-24 The Board Of Trustees Of The Leland Stanford Junior University Ocular gene therapy using avalanche-mediated transfection
US7923251B2 (en) * 2005-02-23 2011-04-12 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for avalanche-mediated transfer of agents into cells
JP2008532560A (ja) * 2005-03-19 2008-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 微弱電界ネットワークを仲介して行う、生体外で細胞内に遺伝子、タンパク質および薬剤を送達する方法および装置
EP1759714A1 (de) * 2005-09-02 2007-03-07 Bioalliance Pharma Elektrotransfer von Nukleinsäuren in Gewebezellen
WO2007117651A2 (en) * 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
WO2008112787A2 (en) * 2007-03-14 2008-09-18 The Regents Of The University Of California Method and apparatus of low strength electric field network-mediated delivery of therapeutics in solid organs
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US20090227948A1 (en) * 2008-03-06 2009-09-10 Boston Scientific Scimed, Inc. Balloon catheter devices with sheath covering
CN101274120B (zh) 2008-04-29 2013-03-13 圣太科医疗科技（上海）有限公司 生物与医用多路低电压微电场发生仪
ES2398052T5 (es) 2008-05-09 2021-10-25 Nuvaira Inc Sistemas para tratar un árbol bronquial
CA2723595A1 (en) * 2008-05-13 2009-11-19 Bio-Rad Laboratories, Inc. Electroporation of adherent cells with an array of closely spaced electrodes
CA2731294A1 (en) * 2008-07-18 2010-01-21 Suntek Medical Scientific And Technologies (Shanghai) Co., Ltd. A multipurpose micro electric field networking cell processing device
WO2010006483A1 (zh) * 2008-07-18 2010-01-21 圣太科医疗科技（上海）有限公司 微电场网引导的肝脏靶向性细胞内药物传递装置
US8207138B2 (en) 2009-05-19 2012-06-26 Medtronic, Inc. Methods and devices for improved efficiency of RNA delivery to cells
US20100298697A1 (en) * 2009-05-19 2010-11-25 Medtronic, Inc. Method and devices for improved efficiency of rna delivery to cells
US8932055B2 (en) * 2009-06-11 2015-01-13 Roberto Armanino Method employing electric fields to selectively kill microbes in a root canal preparation
US20120130150A1 (en) 2009-06-24 2012-05-24 International Scientific Pty Ltd. apparatus and method of treatment utilizing a varying electromagnetic energization profile
JP5767226B2 (ja) * 2009-08-27 2015-08-19 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 医療用デバイス
EP2493408B1 (de) 2009-10-27 2015-06-24 Holaira, Inc. Freisetzungsvorrichtungen mit kühlbaren energieemissionsanordnungen
CN102686147B (zh) 2009-11-05 2016-01-20 格雷特巴奇有限公司 波导神经接口装置
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
KR101820542B1 (ko) 2009-11-11 2018-01-19 호라이라 인코포레이티드 조직을 치료하고 협착을 제어하기 위한 방법, 기구 및 장치
CA2810520C (en) 2010-09-10 2019-03-12 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
EP2675913B1 (de) 2011-02-15 2016-12-14 Bio-Rad Laboratories, Inc. Erkennung von methylierung in einer subpopulation von genomischer dna
WO2013019960A1 (en) 2011-08-03 2013-02-07 Bio-Rad Laboratories, Inc. Filtering small nucleic acids using permeabilized cells
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
WO2019147613A1 (en) * 2018-01-23 2019-08-01 The Regents Of The University Of California Downstream delivery of agents in solid organ transplantation
US10918861B2 (en) * 2018-07-24 2021-02-16 Wisconsin Alumni Research Foundation In vivo gene therapy delivery procedure and device
BR112021007913A2 (pt) * 2018-10-26 2021-08-03 Kytopen Corporation dispositivos, sistemas e kits para eletroporação e métodos de uso dos mesmos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5634899A (en) * 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5795755A (en) * 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6090617A (en) * 1996-12-05 2000-07-18 Entremed, Inc. Flow electroporation chamber with electrodes having a crystalline metal nitride coating
NZ337853A (en) 1997-04-03 2002-03-28 Electrofect As Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents

Also Published As

Publication number Publication date
US6593130B1 (en) 2003-07-15
ATE406936T1 (de) 2008-09-15
EP1210144B1 (de) 2008-09-03
WO2000062855A1 (en) 2000-10-26
EP1210144A1 (de) 2002-06-05
AU4465600A (en) 2000-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee