DE60032632D1 - Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par) - Google Patents
Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par)Info
- Publication number
- DE60032632D1 DE60032632D1 DE60032632T DE60032632T DE60032632D1 DE 60032632 D1 DE60032632 D1 DE 60032632D1 DE 60032632 T DE60032632 T DE 60032632T DE 60032632 T DE60032632 T DE 60032632T DE 60032632 D1 DE60032632 D1 DE 60032632D1
- Authority
- DE
- Germany
- Prior art keywords
- par
- protease
- activated receptors
- identifying modulators
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9929674 | 1999-12-15 | ||
GBGB9929674.1A GB9929674D0 (en) | 1999-12-15 | 1999-12-15 | Protease-activated receptor (PAR) modulator assays |
PCT/EP2000/012673 WO2001044496A2 (en) | 1999-12-15 | 2000-12-13 | Protease-activated receptor (par) modulator assays |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60032632D1 true DE60032632D1 (de) | 2007-02-08 |
DE60032632T2 DE60032632T2 (de) | 2007-11-15 |
Family
ID=10866389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60032632T Expired - Lifetime DE60032632T2 (de) | 1999-12-15 | 2000-12-13 | Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par) |
Country Status (11)
Country | Link |
---|---|
US (1) | US7148018B2 (de) |
EP (1) | EP1238283B1 (de) |
AT (1) | ATE349699T1 (de) |
AU (1) | AU3158501A (de) |
CY (1) | CY1106384T1 (de) |
DE (1) | DE60032632T2 (de) |
DK (1) | DK1238283T3 (de) |
ES (1) | ES2277866T3 (de) |
GB (1) | GB9929674D0 (de) |
PT (1) | PT1238283E (de) |
WO (1) | WO2001044496A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
CA2733041A1 (en) * | 2008-08-05 | 2010-02-11 | Boehringer Ingelheim International Gmbh | Effectors of par-2 activation and their use in the modulation of inflammation |
US9605046B2 (en) * | 2011-11-07 | 2017-03-28 | The Scripps Research Institute | Protease Activated Receptor-1 (PAR1) Derived Cytoprotective Polypeptides and Related Methods |
ES2909709T3 (es) * | 2016-05-12 | 2022-05-10 | Heptares Therapeutics Ltd | Inhibidores del receptor 2 activado por proteasa |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR930701619A (ko) | 1990-06-01 | 1993-06-12 | 레나토 스가르비 | 인체 면역 결핍 바이러스의 gag 단백질 전구체 p55에 대한 단일클론 항체 |
US5235039A (en) * | 1991-06-10 | 1993-08-10 | Eli Lilly And Company | Substrates for hiv protease |
US5605809A (en) * | 1994-10-28 | 1997-02-25 | Oncoimmunin, Inc. | Compositions for the detection of proteases in biological samples and methods of use thereof |
AU4904397A (en) | 1996-10-17 | 1998-05-11 | Chiron Corporation | Protease regulator screening assay |
US5892014A (en) | 1996-10-30 | 1999-04-06 | The Regents Of The University Of California | DNA encoding a protease-activated receptor 3 |
EP0972071A4 (de) | 1997-03-07 | 2004-04-21 | Tropix Inc | Versuchsanordnung für proteaseinhibitoren |
US6111075A (en) | 1998-04-01 | 2000-08-29 | Zymogenetics, Inc. | Protese-activated receptor PAR4 (ZCHEMR2) |
-
1999
- 1999-12-15 GB GBGB9929674.1A patent/GB9929674D0/en not_active Ceased
-
2000
- 2000-12-13 PT PT00991185T patent/PT1238283E/pt unknown
- 2000-12-13 WO PCT/EP2000/012673 patent/WO2001044496A2/en active IP Right Grant
- 2000-12-13 DK DK00991185T patent/DK1238283T3/da active
- 2000-12-13 EP EP00991185A patent/EP1238283B1/de not_active Expired - Lifetime
- 2000-12-13 ES ES00991185T patent/ES2277866T3/es not_active Expired - Lifetime
- 2000-12-13 US US10/149,623 patent/US7148018B2/en not_active Expired - Lifetime
- 2000-12-13 AT AT00991185T patent/ATE349699T1/de active
- 2000-12-13 AU AU31585/01A patent/AU3158501A/en not_active Abandoned
- 2000-12-13 DE DE60032632T patent/DE60032632T2/de not_active Expired - Lifetime
-
2007
- 2007-03-15 CY CY20071100362T patent/CY1106384T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001044496A3 (en) | 2002-05-10 |
ATE349699T1 (de) | 2007-01-15 |
GB9929674D0 (en) | 2000-02-09 |
CY1106384T1 (el) | 2011-10-12 |
EP1238283A2 (de) | 2002-09-11 |
DK1238283T3 (da) | 2007-04-02 |
AU3158501A (en) | 2001-06-25 |
WO2001044496A2 (en) | 2001-06-21 |
US20030148921A1 (en) | 2003-08-07 |
DE60032632T2 (de) | 2007-11-15 |
ES2277866T3 (es) | 2007-08-01 |
EP1238283B1 (de) | 2006-12-27 |
US7148018B2 (en) | 2006-12-12 |
PT1238283E (pt) | 2007-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
R082 | Change of representative |
Ref document number: 1238283 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |