DE50115363D1 - System und verfahren zur multianalytbestimmung - Google Patents

System und verfahren zur multianalytbestimmung

Info

Publication number
DE50115363D1
DE50115363D1 DE50115363T DE50115363T DE50115363D1 DE 50115363 D1 DE50115363 D1 DE 50115363D1 DE 50115363 T DE50115363 T DE 50115363T DE 50115363 T DE50115363 T DE 50115363T DE 50115363 D1 DE50115363 D1 DE 50115363D1
Authority
DE
Germany
Prior art keywords
determination
methods
optical system
sensor platform
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50115363T
Other languages
English (en)
Inventor
Wolfgang Zesch
Martin A Bopp
Michael Pawlak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Technology Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services GmbH filed Critical Bayer Technology Services GmbH
Application granted granted Critical
Publication of DE50115363D1 publication Critical patent/DE50115363D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6419Excitation at two or more wavelengths
DE50115363T 2000-09-04 2001-08-30 System und verfahren zur multianalytbestimmung Expired - Lifetime DE50115363D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH17182000 2000-09-04
PCT/EP2001/010012 WO2002021110A1 (de) 2000-09-04 2001-08-30 System und verfahren zur multianalytbestimmung

Publications (1)

Publication Number Publication Date
DE50115363D1 true DE50115363D1 (de) 2010-04-08

Family

ID=4566018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE50115363T Expired - Lifetime DE50115363D1 (de) 2000-09-04 2001-08-30 System und verfahren zur multianalytbestimmung

Country Status (6)

Country Link
US (1) US7879598B2 (de)
EP (1) EP1327135B1 (de)
AT (1) ATE458992T1 (de)
AU (1) AU2001289853A1 (de)
DE (1) DE50115363D1 (de)
WO (1) WO2002021110A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050054942A1 (en) * 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
US20070167853A1 (en) * 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US6985664B2 (en) * 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
DE10353694A1 (de) * 2003-11-18 2005-06-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikroskopievorrichtung
US7522786B2 (en) * 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
US7310153B2 (en) 2004-08-23 2007-12-18 Palo Alto Research Center, Incorporated Using position-sensitive detectors for wavelength determination
US7274458B2 (en) 2005-03-07 2007-09-25 3M Innovative Properties Company Thermoplastic film having metallic nanoparticle coating
JP5002584B2 (ja) 2005-04-26 2012-08-15 バイエル・テクノロジー・サービシズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 親和性検定方法による分析試料検出用の基質をコーティングするための新規な装置および方法
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US7315667B2 (en) * 2005-12-22 2008-01-01 Palo Alto Research Center Incorporated Propagating light to be sensed
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7547904B2 (en) 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
EP2044420A2 (de) * 2006-07-17 2009-04-08 Max Wiki Analytisches system mit einer anordnung zur zeitlich veränderbaren räumlichen lichtmodulation und damit ausführbares nachweisverfahren
US7914460B2 (en) 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
US7718948B2 (en) 2006-12-04 2010-05-18 Palo Alto Research Center Incorporated Monitoring light pulses
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US7554673B2 (en) * 2007-02-05 2009-06-30 Palo Alto Research Center Incorporated Obtaining information about analytes using optical cavity output light
US7817276B2 (en) 2007-02-05 2010-10-19 Palo Alto Research Center Incorporated Distinguishing objects
US7545513B2 (en) * 2007-02-05 2009-06-09 Palo Alto Research Center Incorporated Encoding optical cavity output light
US7936463B2 (en) * 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
US7633629B2 (en) * 2007-02-05 2009-12-15 Palo Alto Research Center Incorporated Tuning optical cavities
WO2008096296A1 (en) * 2007-02-08 2008-08-14 Koninklijke Philips Electronics N.V. Biosensor with evanescent waveguide and integrated sensor
TWI475874B (zh) * 2007-06-15 2015-03-01 Camtek Ltd 使用多面成像之光學檢查系統
US7522811B2 (en) * 2007-07-13 2009-04-21 Palo Alto Research Center Incorporated Producing sandwich waveguides
US7529438B2 (en) * 2007-07-13 2009-05-05 Palo Alto Research Center Incorporated Producing fluidic waveguides
WO2009079156A2 (en) * 2007-11-20 2009-06-25 3M Innovative Properties Company Detection devices and methods
US8320983B2 (en) 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US7817254B2 (en) * 2008-01-30 2010-10-19 Palo Alto Research Center Incorporated Obtaining information from time variation of sensing results
US8153950B2 (en) * 2008-12-18 2012-04-10 Palo Alto Research Center Incorporated Obtaining sensing results and/or data in response to object detection
US7763856B2 (en) * 2008-01-31 2010-07-27 Palo Alto Research Center Incorporated Producing time variation in emanating light
US7701580B2 (en) * 2008-02-01 2010-04-20 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8153949B2 (en) * 2008-12-18 2012-04-10 Palo Alto Research Center Incorporated Obtaining sensing results indicating time variation
US8263955B2 (en) * 2008-12-18 2012-09-11 Palo Alto Research Center Incorporated Causing relative motion
US7894068B2 (en) * 2008-02-04 2011-02-22 Palo Alto Research Center Incorporated Producing filters with combined transmission and/or reflection functions
US8373860B2 (en) * 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
CN102460254B (zh) * 2009-04-29 2015-05-06 Plc诊断股份有限公司 具有扫描光源的基于波导的检测系统
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
WO2014087380A1 (en) 2012-12-05 2014-06-12 Genepoc Inc. Optical interrogation device
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
US10214367B2 (en) 2016-06-03 2019-02-26 Gruma S.A.B. De C.V. Rotating stacker
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
US10371896B2 (en) 2016-12-22 2019-08-06 Magic Leap, Inc. Color separation in planar waveguides using dichroic filters
EP3677901A4 (de) * 2017-08-31 2021-05-12 Furuno Electric Co., Ltd. Messchip, messvorrichtung und messverfahren
FI128573B (en) * 2018-03-28 2020-08-14 Dispelix Oy Waveguide display element
CA3067154A1 (en) * 2018-03-29 2019-10-03 Illumina, Inc. Illumination for fluorescence imaging using objective lens
DE102019134172A1 (de) 2019-12-12 2021-06-17 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Einkopplung von Licht mit verschiedenen Wellenlängen in einen Wellenleiter
WO2022025967A1 (en) * 2020-07-28 2022-02-03 Adarza Biosystems, Inc. Ultra sensitive methods
DE102020212029A1 (de) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur simultanen Abbildung zweier Objektebenen
DE102020212031A1 (de) 2020-09-24 2022-03-24 Dr. Johannes Heidenhain Gmbh Vorrichtung und Verfahren zur Bestimmung der Intensität des in einem planaren Wellenleiter geführten Lichts IWG(x, y)
US20230111586A1 (en) * 2021-10-12 2023-04-13 Bio-Rad Laboratories, Inc. Consumable for analyte detection

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2207053C2 (de) * 1972-02-15 1984-12-06 Philips Patentverwaltung Gmbh, 2000 Hamburg Röntgen-Bildverstärker-Densitometer
US4698734A (en) * 1984-06-01 1987-10-06 Peerless Lighting Corporation Lensed indirect luminaire with side angle brightness control
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
DE3680999D1 (de) * 1985-05-29 1991-09-26 Artificial Sensing Instr Asi A Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahlaenderungen in messubstanzen.
US4847479A (en) * 1988-06-06 1989-07-11 Trw Inc. System for controlling the wavelength and colinearity of multiplexed laser beams
US5062942A (en) * 1989-04-12 1991-11-05 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5192506A (en) * 1991-02-14 1993-03-09 P B Diagnostic Systems, Inc. Incubator port closure for automated assay system
US6002829A (en) 1992-03-23 1999-12-14 Minnesota Mining And Manufacturing Company Luminaire device
DE69429262T2 (de) 1993-05-18 2002-07-25 Univ Utah Res Found Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
JPH10501616A (ja) 1994-05-27 1998-02-10 ノバルティス アクチエンゲゼルシャフト 漸減励起された発光を検出するための方法
AU5763296A (en) 1995-05-12 1996-11-29 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
US6178224B1 (en) * 1995-06-23 2001-01-23 Science Applications International Corporation Enhanced X-ray converter screen for X-ray radioscopic systems
EP0888546A1 (de) 1996-03-19 1999-01-07 University Of Utah Research Foundation Oszillator und methoden fur multi-analyt fluoro-immunassays
EP0890095B1 (de) 1996-03-30 2007-11-21 Novartis AG Integriert optischer lumineszenzsensor
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
DE59703919D1 (de) 1996-08-16 2001-08-02 Zeptosens Ag Witterswil Optische detektionsvorrichtung
US5982534A (en) * 1997-06-18 1999-11-09 The Regents Of The University Of California Specimen illumination apparatus with optical cavity for dark field illumination
DE19726597C1 (de) 1997-06-23 1998-11-19 Wengler Georg S Verfahren zur Herstellung von monoklonalen Antikörper
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
DE69902023T2 (de) * 1998-01-23 2003-02-27 Torsana Biosensor As Vedbaek Nachweis einer substanz durch brechzahländerung
AU5526500A (en) 1999-06-05 2000-12-28 Zeptosens Ag Sensor platform and method for analysing multiple analytes
ATE516492T1 (de) 1999-08-13 2011-07-15 Bayer Technology Services Gmbh Vorrichtung und verfahren zur multianalytbestimmung
US6961490B2 (en) * 2000-01-27 2005-11-01 Unaxis-Balzers Aktiengesellschaft Waveguide plate and process for its production and microtitre plate

Also Published As

Publication number Publication date
US7879598B2 (en) 2011-02-01
EP1327135B1 (de) 2010-02-24
AU2001289853A1 (en) 2002-03-22
US20040038386A1 (en) 2004-02-26
ATE458992T1 (de) 2010-03-15
EP1327135A1 (de) 2003-07-16
WO2002021110A1 (de) 2002-03-14

Similar Documents

Publication Publication Date Title
DE50115363D1 (de) System und verfahren zur multianalytbestimmung
BR0214878A (pt) Sistema, analisador e processo para detectar um analito em uma amostra
BR9710836A (pt) Ensaio de analitos usando marcas em partìculas
ATE344452T1 (de) Optische vorrichtung und verfahren zur messung von lichttransmission
SE0201191D0 (sv) Optical component based temperature measurement in analyte detection devices
EP1205753A3 (de) Multiplexsensor und Anwendungsverfahren
ATE321258T1 (de) Positionsempfindlicher detektor zur erfassung eines lichtpunkts
DE69804612D1 (de) Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten
DE60014348T8 (de) Messung und verwendung von molekularen wechselwirkungen
DK1077634T3 (da) Monitorering af fysiologiske analytter
ATE458987T1 (de) Intelligentes system zur optischen messung von proben
HRP20060118A2 (en) Method and device for the detection of very small quantities of particles
DE60235999D1 (de) Verfahren zur messung von lichtabsorptionseigenschaften einer biologischen gewebsprobe
WO2003023353A3 (en) Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
DE69105978T2 (de) Verfahren zur verminderung von störungen in einer fluoreszenzbestimmung.
ATE333091T1 (de) Verfahren zur messung von blutersatzstoffen
ATE342500T1 (de) Verfahren zur erkennung und kompensation der unterdosierung von teststreifen
DE60137748D1 (de) Analysesystem zur Feststellung der Stickstoffkonzentration mit hoher Genauigkeit
DE50110761D1 (de) Verfahren und Vorrichtung zur Erfassung von Informationen für die Überwachung einer Laseranordnung
ATE350656T1 (de) Vorrichtung und verfahren zur bestimmung der chromatischen dispersion von optischen komponenten
DE602004021673D1 (de) Verfahren und vorrichtungen zur gewichtsmessung
DK1054623T3 (da) Reproducerbar positions- eller holdningsidentifikation af deformerbare kroppe
ATE513201T1 (de) Doppelbrechungsmessung von grossformatigen optischen elementen
ATE399316T1 (de) Verfahren zur feststellung von einer thiol enthaltenden zusammensetzung
ATE270581T1 (de) Lipidmembran, verfahren zur messung der membranpermeabilität und screeningmethode

Legal Events

Date Code Title Description
8364 No opposition during term of opposition