DE3856354T2 - Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren - Google Patents

Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren

Info

Publication number
DE3856354T2
DE3856354T2 DE3856354T DE3856354T DE3856354T2 DE 3856354 T2 DE3856354 T2 DE 3856354T2 DE 3856354 T DE3856354 T DE 3856354T DE 3856354 T DE3856354 T DE 3856354T DE 3856354 T2 DE3856354 T2 DE 3856354T2
Authority
DE
Germany
Prior art keywords
receptor
retinoic acid
novel
glucocorticoid
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3856354T
Other languages
English (en)
Other versions
DE3856354D1 (de
Inventor
Ronald Mark Evans
Vincent Giguere
Estelita Sebastian Ong
Prudimar Serrano Segui
Kazuhiko Umesono
Catherine Caroline Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26826487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3856354(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of DE3856354D1 publication Critical patent/DE3856354D1/de
Application granted granted Critical
Publication of DE3856354T2 publication Critical patent/DE3856354T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
DE3856354T 1987-12-02 1988-12-02 Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren Expired - Fee Related DE3856354T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12833187A 1987-12-02 1987-12-02
US07/276,536 US4981784A (en) 1987-12-02 1988-11-30 Retinoic acid receptor method

Publications (2)

Publication Number Publication Date
DE3856354D1 DE3856354D1 (de) 1999-09-02
DE3856354T2 true DE3856354T2 (de) 1999-12-16

Family

ID=26826487

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3856354T Expired - Fee Related DE3856354T2 (de) 1987-12-02 1988-12-02 Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren
DE3854120T Expired - Fee Related DE3854120T2 (de) 1987-12-02 1988-12-02 Retinoesäure-Rezeptor-Komposition und Verfahren zur Ligand-Identifizierung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3854120T Expired - Fee Related DE3854120T2 (de) 1987-12-02 1988-12-02 Retinoesäure-Rezeptor-Komposition und Verfahren zur Ligand-Identifizierung.

Country Status (11)

Country Link
US (2) US4981784A (de)
EP (2) EP0540065B1 (de)
JP (3) JP3006716B2 (de)
KR (1) KR970009951B1 (de)
AT (2) ATE124721T1 (de)
AU (1) AU628312B2 (de)
DE (2) DE3856354T2 (de)
DK (1) DK136890D0 (de)
ES (1) ES2073408T3 (de)
IE (1) IE68590B1 (de)
WO (1) WO1989005355A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317090A (en) * 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
EP0321362B1 (de) * 1987-12-16 1996-09-25 Institut Pasteur Retinoesäurerezeptor und Derivate davon, beide Substanzen codierende DNS und die Verwendung der Proteine und der DNS
US5217867A (en) 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
AU633045B2 (en) * 1988-12-23 1993-01-21 Salk Institute For Biological Studies, The Receptor transcription-repression activity compositions and methods
WO1990011273A1 (en) * 1989-03-17 1990-10-04 The Salk Institute For Biological Studies Hormone response element compositions and assay
EP0473716A4 (en) * 1989-05-26 1992-09-09 The Salk Institute For Biological Studies Dominant negative members of the steroid/thyroid superfamily of receptors
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5776502A (en) * 1989-07-18 1998-07-07 Oncogene Science, Inc. Methods of transcriptionally modulating gene expression
US5665543A (en) * 1989-07-18 1997-09-09 Oncogene Science, Inc. Method of discovering chemicals capable of functioning as gene expression modulators
WO1991006677A1 (en) * 1989-10-25 1991-05-16 The Salk Institute For Biological Studies Receptor infection assay
CA2034220A1 (en) * 1990-01-16 1991-07-17 Donald P. Mcdonnell Expression vectors that produce steroid receptors, steroid receptor chimera, screening assays for steroid receptors and clinical assays using synthesized receptors and receptor vector
EP0514488B1 (de) * 1990-02-09 2000-09-13 The Salk Institute For Biological Studies Retinoid-rezeptor-zusammensetzungen und verfahren
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
WO1991014695A1 (en) * 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US5688691A (en) * 1990-03-22 1997-11-18 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
US5599906A (en) * 1990-04-13 1997-02-04 Schering Corporation Protease assays
DK106490D0 (da) * 1990-04-30 1990-04-30 Novo Nordisk As Celle
IL97996A0 (en) * 1990-04-30 1992-06-21 Novo Nordisk As Hybrid cellular receptor
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
CZ49693A3 (en) * 1990-09-24 1994-02-16 Gen Hospital Corp Method for testing of a compound capability to inhibit onco-protein activity
US5922596A (en) * 1990-12-10 1999-07-13 Bristol-Myers Squibb Co. Promoter of the retinoic acid receptor gene for directing gene expression
US5604115A (en) * 1990-12-21 1997-02-18 The Rockefeller University Liver enriched transcription factor
JPH06508507A (ja) * 1991-03-18 1994-09-29 ザ　ソールク　インスチチュート　フォア　バイオロジカル　スタディズ 受容体認識配列組成物およびこれを用いた分析法
US5834213A (en) * 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
WO1992022667A1 (en) * 1991-06-14 1992-12-23 University Of Medicine And Dentistry Of New Jersey Analogs of glycoprotein hormone receptors which bind choriogonadotrophins, leutrophins, and follitrophins and methods for preparing and using same
WO1993003713A1 (en) * 1991-08-23 1993-03-04 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
US5871909A (en) * 1991-08-30 1999-02-16 The Regents Of The University Of Michigan Human cellular retinoic acid binding protein I and II DNA and methods of use
AU2579692A (en) * 1991-09-17 1993-04-27 Salk Institute For Biological Studies, The Receptor of the thyroid/steroid hormone receptor superfamily
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US7056954B2 (en) * 1991-12-18 2006-06-06 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
US6506917B1 (en) * 1991-12-18 2003-01-14 The Salk Institute For Biological Studies Compounds and compositions useful for modulation of processes mediated by RXR
US5968989A (en) 1991-12-18 1999-10-19 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
EP0552612A3 (en) * 1992-01-22 1993-10-20 Hoffmann La Roche Methods for determining and isolating compounds which bind directly to nucleosolic proteins
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
US5808139A (en) * 1992-04-21 1998-09-15 Ligand Pharmaceuticals Incorporated Non-steroid progesterone receptor agonist and antagonist and compounds and methods
MX9302312A (es) * 1992-04-21 1994-06-30 Ligand Pharm Inc Compuestos agonistas y antagonistas receptores de la progesterona, no esteroides y composiciones farmaceuticas que los contienen.
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5962731A (en) * 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
EP0640093A4 (de) * 1992-04-28 1996-06-05 Univ Michigan Menschlisches crabp-i und crabp-ii.
US6416998B1 (en) * 1992-09-02 2002-07-09 Baylor College Of Medicine Plasmid encoding a modified steroid hormone
AU685054C (en) * 1992-05-14 2003-02-27 Baylor College Of Medicine Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
EP0675967A4 (de) * 1992-10-01 1999-04-28 Gen Hospital Corp Funktionelle prüfung für tumorsuppressorgene.
AU5165193A (en) * 1992-10-07 1994-04-26 Merck & Co., Inc. Human steroid hormone receptor neri
ATE160178T1 (de) * 1993-01-21 1997-11-15 Harvard College Verfahren und diagnostische kits unter verwendung von säuger-stresspromotoren zur bestimmung der toxizität einer verbindung
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
WO1994018317A1 (en) * 1993-02-12 1994-08-18 The Board Of Trustees Of The Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
JP3628691B2 (ja) * 1993-03-08 2005-03-16 メルク エンド カンパニー インコーポレーテッド ヒト神経細胞性ニコチン性アセチルコリン受容体組成物およびそれらの使用方法
SG54115A1 (en) * 1993-04-27 1998-11-16 Gerber Scient Products Inc Thermal printing apparatus with improved power supply
JPH08504104A (ja) * 1993-05-18 1996-05-07 アンスティテュー・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル レチノイン酸レセプター蛋白をコード化する遺伝子における改変を含む遺伝子工学的マウス
US6031149A (en) * 1993-05-18 2000-02-29 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
US5506102A (en) * 1993-10-28 1996-04-09 Ligand Pharmaceuticals Incorporated Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription
GB2287941B (en) * 1993-11-08 1998-01-28 Salk Inst Biotech Ind Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same
US5523209A (en) * 1994-03-14 1996-06-04 The Scripps Research Institute Methods for identifying inhibitors of integrin activation
EP0753147A1 (de) * 1994-03-30 1997-01-15 Novartis AG Screeningsverfahren unter verwendung der rzr rezeptorfamilie
CA2194169A1 (en) * 1994-07-01 1996-01-18 Ronald M. Evans Mammalian peroxisome proliferator-activated receptors and uses thereof
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US5679518A (en) * 1994-10-27 1997-10-21 Merck & Co., Inc. Method for finding transcription activators of the NER steroid hormone receptor
US5607967A (en) * 1994-10-27 1997-03-04 Merck & Co., Inc. Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid
US5702914A (en) * 1994-12-21 1997-12-30 The Salk Institute For Biological Studies Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
US5932699A (en) * 1995-01-13 1999-08-03 The General Hospital Corporation Retinoid X receptor-interacting polypeptides
WO1996022390A1 (en) * 1995-01-17 1996-07-25 The Salk Institute For Biological Studies Methods, polypeptides, nucleotide sequence of xor-6, a vitamin d-like receptor from xenopus
FR2732035B1 (fr) * 1995-03-23 1997-05-30 Agronomique Inst Nat Rech Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
AU4745996A (en) * 1995-04-28 1996-11-18 Wisconsin Alumni Research Foundation Method for measuring hormones in biological samples
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
US5726050A (en) * 1995-06-20 1998-03-10 Massachusetts Institute Of Technology Z-DNA binding protein and applications
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US6326140B1 (en) * 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US6489441B1 (en) 1995-09-01 2002-12-03 The Salk Institute For Biological Studies Transcriptional co-repressor that interacts with nuclear hormone receptors
ATE183516T1 (de) * 1995-09-08 1999-09-15 Karobio Ab Waisen-rezeptor
WO1997010813A1 (en) 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
PT873295E (pt) * 1995-10-06 2003-08-29 Ligand Pharm Inc Moduladores de rxr selectivos para dimeros para a sua utilizacao
HUP9900029A3 (en) 1995-10-10 2001-02-28 Novartis Ag Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
US20030044914A1 (en) * 1996-01-16 2003-03-06 The Salk Institute For Biological Studies Methods employing XOR-6, a vitamin D-like receptor from xenopus
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US5919667A (en) * 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
US6017924A (en) 1996-06-27 2000-01-25 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
WO1998027986A1 (en) * 1996-12-24 1998-07-02 Zymogenetics, Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
US6268165B1 (en) 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
US6184256B1 (en) 1997-04-24 2001-02-06 INSTITUT NATIONAL DE LA SANTé DE LA RECHERCHE MéDICALE Methods and compositions for use in modulating expression of matrix metalloproteinase genes
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
US6222015B1 (en) 1997-09-08 2001-04-24 Merck & Co., Inc. Estrogen receptor
US6521814B1 (en) 1997-12-22 2003-02-18 Institut National De La Santa Et De La Recherche Medicale Use of ligands for treatment of diseases responsive to retinoids
US6348348B1 (en) 1998-04-07 2002-02-19 The Carnegie Institution Of Washington Human hairless gene and protein
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
WO1999063980A1 (en) * 1998-06-12 1999-12-16 Ligand Pharmaceuticals Inc. Treatment of anti-estrogen resistant breast cancer using rxr modulators
JP2002525053A (ja) * 1998-09-10 2002-08-13 パイオニア ハイ−ブレッド インターナショナル， インコーポレイテッド エクジソンレセプターおよびそれらの使用のための方法
AU6394399A (en) * 1998-09-18 2000-04-10 Rockefeller University, The Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses thereof
DE19855013C2 (de) 1998-11-20 2001-09-13 Schering Ag Androgen- und Progesteron-Rezeptor bindendes Hormon Response Element
US6773911B1 (en) * 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
US7056656B1 (en) 1999-01-25 2006-06-06 University Of Medicine And Dentistry Of New Jersey Tat-derived oligourea and its method of production and use in high affinity and specific binding HIV-1 TAR RNA
US20020132223A1 (en) * 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
US6586189B2 (en) 1999-06-18 2003-07-01 City Of Hope Screening method for PPAR-γ ligands
US6548739B2 (en) * 1999-06-18 2003-04-15 City Of Hope Method for activating peroxisome proliferator activated receptor-γ
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
WO2001016139A1 (en) 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
WO2001016597A1 (en) * 1999-09-01 2001-03-08 Institut National De La Sante Et De La Recherche Medicale In vitro transcription systems and uses
AU7586600A (en) * 1999-09-14 2001-04-17 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
AU782115B2 (en) * 1999-09-22 2005-07-07 Ortho-Mcneil Pharmaceutical, Inc. Cell based assay
DK1955700T3 (da) 1999-09-30 2011-05-23 Harbor Biosciences Inc Terapeutisk behandling af androgenreceptor-betingede lidelser
US7057015B1 (en) * 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
JP4048053B2 (ja) 1999-11-26 2008-02-13 マクギル ユニバーシティー 特発性全身てんかんについてのローカス、当該ローカスのミューテーション、及びてんかんの評価、診断、予後、または治療のための当該ローカスの使用方法
ES2436610T3 (es) 2000-01-21 2014-01-03 Novartis Ag Combinaciones que contienen inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
AU2001252944A1 (en) * 2000-03-24 2001-10-08 City Of Hope Methods of modulating drug clearance mechanisms by altering SXR activity
AU2001271579A1 (en) * 2000-06-28 2002-01-08 University Technology Corporation Progesterone receptor-regulated gene expression and methods related thereto
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
AU2001272544B2 (en) * 2000-07-18 2005-12-01 The Scripps Research Institute Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
WO2002061102A2 (en) * 2000-10-24 2002-08-08 Syngenta Participations Ag Control of gene expression in plants
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) * 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
US20040053839A1 (en) * 2000-12-21 2004-03-18 Andrea Leblanc Method of protecting cells against apoptosis and assays to identify agents which modulate apoptosis
CA2441444C (en) 2001-02-20 2013-09-03 Rheogene Holdings, Inc. Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
WO2002066612A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2438119C (en) * 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
DK1534738T3 (da) 2001-02-20 2012-10-01 Intrexon Corp Nye substitutionsmutantreceptorer og anvendelse heraf i et inducérbart genekpressionssystem på basis af en nuklear receptor
US7214690B2 (en) * 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US20040102367A1 (en) * 2001-02-23 2004-05-27 Gage Fred H Gene expression system based on chimeric receptors
US7026484B2 (en) * 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US20040143015A1 (en) * 2001-03-12 2004-07-22 Villhauer Edwin Bernard Combination of organic compounds
CA2438874A1 (en) * 2001-03-14 2002-09-19 Eli Lilly And Company Fluorinated trienes and their use as rxr modulators
US20030003517A1 (en) * 2001-03-22 2003-01-02 Klein Elliott S. Methods of detecting dissociated nuclear hormone receptor ligands
US20050176928A1 (en) * 2001-03-23 2005-08-11 Syngenta Participations Ag Insect nuclear receptor genes and uses thereof
WO2002086064A2 (en) * 2001-04-20 2002-10-31 The Salk Institute For Biological Studies Inducible expression of transfected genes
US20110313230A1 (en) 2001-05-11 2011-12-22 Terrance Grant Johns Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
ES2552281T3 (es) 2001-05-11 2015-11-26 Ludwig Institute For Cancer Research Ltd. Proteínas de unión específica y usos de las mismas
US7150971B2 (en) * 2001-05-21 2006-12-19 The Regents Of The University Of California Membrane-resident steroid receptors and methods of use thereof
CA2452541A1 (en) * 2001-07-20 2003-01-30 Eli Lilly And Company (pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators
AU2002333682A1 (en) * 2001-08-02 2003-02-17 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
EP1288303A1 (de) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Induzierbare Expressionssysteme unter Verwendung von PPAR Transkriptionsaktivatoren
MXPA04002810A (es) 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
JP2005507247A (ja) * 2001-09-26 2005-03-17 レオジーン・ホールディングス，インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
US20030077645A1 (en) * 2001-09-28 2003-04-24 Hager Gordon L. Superfamily receptor chimeras, translocation assay for superfamily receptor ligands, and methods and kits for detecting and characterizing receptor ligands
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
JP4817657B2 (ja) * 2002-05-29 2011-11-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 誘導性の真核生物発現システム
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP1388352A1 (de) 2002-08-08 2004-02-11 Laboratoires Fournier S.A. Verwendung eines ppar-alpha-Agonisten zur Behandlung von Patienten, die an mit ppar-gamma-Agonisten-Behandlung assozierter Fettleibigkeit leiden
US7514233B2 (en) 2002-09-26 2009-04-07 K.U. Leuven Research & Development Integrase cofactor
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) * 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP1641555B1 (de) 2003-04-30 2020-12-02 Nexus Biosystems, Inc. Hochdichte lagerung und eine analyseplattform bereitstellende mehrlochplatte
MXPA06001751A (es) * 2003-08-22 2006-05-12 Ligand Pharm Inc Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno.
US7767792B2 (en) 2004-02-20 2010-08-03 Ludwig Institute For Cancer Research Ltd. Antibodies to EGF receptor epitope peptides
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
AU2005247943A1 (en) 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
US20090214514A1 (en) * 2004-07-23 2009-08-27 Leif Kongskov Larsen Gus3 neuropeptides for regulating hypothalamic function
US7544838B2 (en) 2005-01-21 2009-06-09 City Of Hope Ligands for estrogen related receptors and methods for synthesis of said ligands
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
KR101293935B1 (ko) * 2005-06-17 2013-08-08 리간드 파마슈티칼스 인코포레이티드 안드로겐 수용체 조절 화합물 및 방법
PL1931350T5 (pl) 2005-09-14 2021-11-15 Takeda Pharmaceutical Company Limited Podanie inhibitorów dipeptydylo-peptydazy
US20090275070A1 (en) * 2005-11-23 2009-11-05 Housey Gerard M Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
US20080107597A1 (en) * 2006-01-12 2008-05-08 Anaptys Biosciences, Inc. Isolation of antibodies that cross-react and neutralize rankl originating from multiple species
CN104761466A (zh) 2007-05-29 2015-07-08 英特拉克森公司 通过蜕皮素受体复合物调节外源性基因表达的手性二酰基肼配体
MX2010001993A (es) 2007-08-23 2010-03-11 Intrexon Corp Metodos y composiciones para diagnosticar una enfermedad.
EP2205249B1 (de) 2007-09-28 2018-11-07 Intrexon Corporation Therapeutische genschalterkonstrukte und bioreaktoren zur expression biotherapeutischer moleküle und ihre verwendung
JP2010539993A (ja) * 2007-10-08 2010-12-24 イントレキソン コーポレーション 遺伝子操作した樹状細胞および癌の治療のための使用
WO2009082437A2 (en) 2007-12-21 2009-07-02 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (sarms) and uses thereof
MX2010009996A (es) 2008-03-14 2010-10-20 Intrexon Corp Ligandos esteroides y su uso en la modulacion de genes interruptores.
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
CA2787360C (en) 2010-02-03 2019-03-05 Takeda Pharmaceutical Company Limited Pyrrol0[3,2-c]pyridinyl-4-benzamide compounds and their use as apoptosis signal-regulating kinase 1 inhibitors
TWI688395B (zh) 2010-03-23 2020-03-21 英翠克頌公司 條件性表現治療性蛋白質之載體、包含該載體之宿主細胞及彼等之用途
WO2012122025A2 (en) 2011-03-04 2012-09-13 Intrexon Corporation Vectors conditionally expressing protein
CN105283439B (zh) 2013-03-15 2018-02-02 英特瑞克斯顿股份有限公司 含硼的二酰基肼类化合物
WO2015108988A2 (en) 2014-01-17 2015-07-23 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
JP6567657B2 (ja) 2014-09-17 2019-08-28 イントレキソン コーポレーション ホウ素含有ジアシルヒドラジン化合物
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
NZ752941A (en) 2016-11-09 2023-04-28 Intrexon Corp Frataxin expression constructs
EP3612210A4 (de) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System Manipulierte antigenrezeptoren exprimierende immunzellen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5171671A (en) * 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5274077A (en) * 1987-12-02 1993-12-28 The Salk Institute For Biological Studies Retinoic acid receptor composition

Also Published As

Publication number Publication date
EP0540065B1 (de) 1999-07-28
ATE182685T1 (de) 1999-08-15
KR900700601A (ko) 1990-08-16
DK136890A (da) 1990-06-01
ES2073408T3 (es) 1995-08-16
DK136890D0 (da) 1990-06-01
AU2818889A (en) 1989-07-05
JPH10279599A (ja) 1998-10-20
EP0540065A1 (de) 1993-05-05
IE68590B1 (en) 1996-06-26
AU628312B2 (en) 1992-09-17
DE3856354D1 (de) 1999-09-02
IE883621L (en) 1989-06-02
EP0325849B1 (de) 1995-07-05
WO1989005355A1 (en) 1989-06-15
US4981784A (en) 1991-01-01
KR970009951B1 (ko) 1997-06-19
JPH03503597A (ja) 1991-08-15
US5599904A (en) 1997-02-04
JP3006716B2 (ja) 2000-02-07
JPH10295385A (ja) 1998-11-10
ATE124721T1 (de) 1995-07-15
EP0325849A3 (de) 1991-10-16
DE3854120T2 (de) 1996-01-11
EP0325849A2 (de) 1989-08-02
DE3854120D1 (de) 1995-08-10

Similar Documents

Publication Publication Date Title
DE3856354D1 (de) Verfahren zur Identifizierung von Liganden für Retinsäurerezeptoren
Simon et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17; 22)(q22; q13. 1) in dermatofibrosarcoma protuberans (DP)
Kent et al. A male-specific role for SOX9 in vertebrate sex determination
Corps et al. Receptors for epidermal growth factor and insulin-like growth factor-I on preimplantation trophoderm of the pig
Phillips et al. [125I] EGF binding ability is stable throughout the replicative life‐span of WI‐38 cells
DE155247T1 (de) Verfahren zur mikrophotometrie von mikroskopischen prueflingen, apparat zur ausfuehrung dieses verfahrens.
DE69531302D1 (de) Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren
DE3851967D1 (de) Verfahren zur Bestimmung von Antikörpern.
ATE177147T1 (de) Säugetier-rezeptoren für interleukin 10 (il-10)
ATE139784T1 (de) Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten
ATE172989T1 (de) Bnp antikörper und immunologischer nachweis der ihn benutzt
DE69029197T2 (de) Gamma-retinoinsäure-rezeptor
ES2061273T3 (es) Ensayo para proteinas glicadas de la sangre.
DE69030579T2 (de) Verfahren zur herstellung von fusionsproteinen
ATA348779A (de) Verfahren zur gewinnunng von proteinen aus milchserum
WO2000001817A3 (en) Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
KR950700328A (ko) 레티노산 응답요소의 구성 활성화인자 수용체 및 관련 분자와 방법(carreceptors and related molecules and methods)
DE69637154D1 (de) Hocheffizientes gewebespezifisches system zur bereitstellung von verbindungen unter verwendung eines streptavidin-protein a fusionsproteins
DE19728991A1 (de) Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
WO2002008723A2 (de) Verfahren zur selektiven bestimmung von blockierenden autoantikörpern gegen den tsh-rezeptor
Evans et al. Chimeric steroid hormone superfamily receptor proteins
JP4147305B2 (ja) ヒト成体由来の膵臓内分泌細胞に分化可能な細胞に特有な表面抗原とこの表面抗原による細胞分離法
WO2000034335A3 (en) 'death domain' containing receptors
Fry et al. Adenoviral‐mediated expression of functional na+ channel β1 subunits tagged with a yellow fluorescent protein
JPH01501896A (ja) 多色ウエスタンブロット

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee