US5430136A
(en)
*
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
US5258506A
(en)
*
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
US5714380A
(en)
|
1986-10-23 |
1998-02-03 |
Amoco Corporation |
Closed vessel for isolating target molecules and for performing amplification
|
US6147198A
(en)
*
|
1988-09-15 |
2000-11-14 |
New York University |
Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
|
US5720928A
(en)
*
|
1988-09-15 |
1998-02-24 |
New York University |
Image processing and analysis of individual nucleic acid molecules
|
US5324829A
(en)
*
|
1988-12-16 |
1994-06-28 |
Ortho Diagnostic Systems, Inc. |
High specific activity nucleic acid probes having target recognition and signal generating moieties
|
US6610256B2
(en)
|
1989-04-05 |
2003-08-26 |
Wisconsin Alumni Research Foundation |
Image processing and analysis of individual nucleic acid molecules
|
US5102784A
(en)
*
|
1990-05-04 |
1992-04-07 |
Oncor, Inc. |
Restriction amplification assay
|
US5677440A
(en)
*
|
1990-07-16 |
1997-10-14 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates
|
EP0529070A1
(de)
*
|
1991-02-27 |
1993-03-03 |
Amoco Corporation |
Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays
|
KR940701454A
(ko)
*
|
1991-06-17 |
1994-05-28 |
로버트 피. 블랙버언 |
선택가능한 절단부위로의 폴리뉴클레오티드의 결정
|
US5294534A
(en)
*
|
1991-08-13 |
1994-03-15 |
Miles, Inc. |
Amplification method for polynucleotide assays
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US6872816B1
(en)
*
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
US5994069A
(en)
|
1996-01-24 |
1999-11-30 |
Third Wave Technologies, Inc. |
Detection of nucleic acids by multiple sequential invasive cleavages
|
WO1993005184A1
(en)
*
|
1991-09-10 |
1993-03-18 |
Love Jack D |
Dna/rna target and signal amplification
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
US6569382B1
(en)
*
|
1991-11-07 |
2003-05-27 |
Nanogen, Inc. |
Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
|
US6652808B1
(en)
*
|
1991-11-07 |
2003-11-25 |
Nanotronics, Inc. |
Methods for the electronic assembly and fabrication of devices
|
US5632957A
(en)
*
|
1993-11-01 |
1997-05-27 |
Nanogen |
Molecular biological diagnostic systems including electrodes
|
GB9207380D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Compounds
|
GB9207381D0
(en)
*
|
1992-04-03 |
1992-05-13 |
Ici Plc |
Synthesis of oligonucleotides
|
JPH07505297A
(ja)
*
|
1992-04-06 |
1995-06-15 |
アボツト・ラボラトリーズ |
内面全反射を使用して核酸または被分析物質を検出する方法及び装置
|
US5543292A
(en)
*
|
1992-06-16 |
1996-08-06 |
Hitachi, Ltd. |
Process for the measurement of nucleic acids
|
US5795714A
(en)
*
|
1992-11-06 |
1998-08-18 |
Trustees Of Boston University |
Method for replicating an array of nucleic acid probes
|
US6436635B1
(en)
*
|
1992-11-06 |
2002-08-20 |
Boston University |
Solid phase sequencing of double-stranded nucleic acids
|
US5614402A
(en)
*
|
1992-12-07 |
1997-03-25 |
Third Wave Technologies, Inc. |
5' nucleases derived from thermostable DNA polymerase
|
US5605798A
(en)
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
EP1262564A3
(de)
|
1993-01-07 |
2004-03-31 |
Sequenom, Inc. |
Dns-Sequenzierung durch Massenspektrometrie
|
WO1994016103A2
(en)
*
|
1993-01-08 |
1994-07-21 |
Hybridon, Inc. |
Detection of synthetic oligonucleotides extracted from body fluids or tissues
|
US5679510A
(en)
*
|
1993-04-27 |
1997-10-21 |
Hybridon, Inc. |
Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
|
JP2842758B2
(ja)
*
|
1993-05-10 |
1999-01-06 |
株式会社日立製作所 |
自動分析装置
|
US7314708B1
(en)
*
|
1998-08-04 |
2008-01-01 |
Nanogen, Inc. |
Method and apparatus for electronic synthesis of molecular structures
|
US6331274B1
(en)
|
1993-11-01 |
2001-12-18 |
Nanogen, Inc. |
Advanced active circuits and devices for molecular biological analysis and diagnostics
|
US6225059B1
(en)
|
1993-11-01 |
2001-05-01 |
Nanogen, Inc. |
Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
|
AU692212B2
(en)
*
|
1993-12-17 |
1998-06-04 |
Roger S. Cubicciotti |
Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
|
US20050123926A1
(en)
*
|
1994-01-13 |
2005-06-09 |
Enzo Diagnostics, Inc., |
In vitro process for producing multiple nucleic acid copies
|
US6986985B1
(en)
|
1994-01-13 |
2006-01-17 |
Enzo Life Sciences, Inc. |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
|
US20110097791A1
(en)
*
|
1999-04-16 |
2011-04-28 |
Engelhardt Dean L |
Novel process, construct and conjugate for producing multiple nucleic acid copies
|
US5484702A
(en)
*
|
1994-01-27 |
1996-01-16 |
Research Foundation Of The State University Of New York At Buffalo |
Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones
|
US6110709A
(en)
*
|
1994-03-18 |
2000-08-29 |
The General Hospital Corporation |
Cleaved amplified modified polymorphic sequence detection methods
|
AU2187295A
(en)
*
|
1994-03-18 |
1995-10-09 |
General Hospital Corporation, The |
Cleaved amplified rflp detection methods
|
US5714330A
(en)
*
|
1994-04-04 |
1998-02-03 |
Lynx Therapeutics, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5552278A
(en)
*
|
1994-04-04 |
1996-09-03 |
Spectragen, Inc. |
DNA sequencing by stepwise ligation and cleavage
|
US5831065A
(en)
*
|
1994-04-04 |
1998-11-03 |
Lynx Therapeutics, Inc. |
Kits for DNA sequencing by stepwise ligation and cleavage
|
US6589736B1
(en)
|
1994-11-22 |
2003-07-08 |
The Trustees Of Boston University |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
|
US6593086B2
(en)
|
1996-05-20 |
2003-07-15 |
Mount Sinai School Of Medicine Of New York University |
Nucleic acid amplification methods
|
US5942391A
(en)
*
|
1994-06-22 |
1999-08-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method: ramification-extension amplification method (RAM)
|
USRE38442E1
(en)
*
|
1994-06-22 |
2004-02-24 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US20070269799A9
(en)
*
|
1994-06-22 |
2007-11-22 |
Zhang David Y |
Nucleic acid amplification methods
|
US5876924A
(en)
*
|
1994-06-22 |
1999-03-02 |
Mount Sinai School Of Medicine |
Nucleic acid amplification method hybridization signal amplification method (HSAM)
|
US5552471A
(en)
*
|
1994-08-17 |
1996-09-03 |
The Perkin-Elmer Corporation |
Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
|
US5580731A
(en)
*
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
US5597909A
(en)
*
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
US6232465B1
(en)
|
1994-09-02 |
2001-05-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US6214987B1
(en)
*
|
1994-09-02 |
2001-04-10 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
|
US5872244A
(en)
*
|
1994-09-02 |
1999-02-16 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US5763594A
(en)
*
|
1994-09-02 |
1998-06-09 |
Andrew C. Hiatt |
3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
|
US5808045A
(en)
*
|
1994-09-02 |
1998-09-15 |
Andrew C. Hiatt |
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
US5990300A
(en)
*
|
1994-09-02 |
1999-11-23 |
Andrew C. Hiatt |
Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
US6013445A
(en)
*
|
1996-06-06 |
2000-01-11 |
Lynx Therapeutics, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
US6974666B1
(en)
|
1994-10-21 |
2005-12-13 |
Appymetric, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
US5660979A
(en)
*
|
1994-11-04 |
1997-08-26 |
Akzo Nobel N.V. |
Detection of human retrovirus infection
|
US20030104361A1
(en)
|
1997-09-29 |
2003-06-05 |
Susan Weininger |
Method of detection of nucleic acids with a specific sequence composition
|
US5871902A
(en)
*
|
1994-12-09 |
1999-02-16 |
The Gene Pool, Inc. |
Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
|
EP0842294B1
(de)
*
|
1994-12-23 |
2002-10-23 |
Dade Behring Inc. |
Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
|
EP0724015B1
(de)
*
|
1995-01-12 |
2004-03-31 |
Toyo Boseki Kabushiki Kaisha |
Neue alkalische Phosphatase, deren Herstellung und Verwendung
|
US5559000A
(en)
*
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
US6428955B1
(en)
|
1995-03-17 |
2002-08-06 |
Sequenom, Inc. |
DNA diagnostics based on mass spectrometry
|
US8142708B2
(en)
*
|
1995-04-03 |
2012-03-27 |
Wisconsin Alumni Research Foundation |
Micro fluidic system for single molecule imaging
|
US7775368B2
(en)
*
|
1995-04-03 |
2010-08-17 |
Wisconsin Alumni Research Foundation |
Micro-channel long molecule manipulation system
|
WO1996031522A1
(en)
|
1995-04-03 |
1996-10-10 |
New York University |
Methods for measuring physical characteristics of nucleic acids by microscopic imaging
|
US20060063193A1
(en)
*
|
1995-04-11 |
2006-03-23 |
Dong-Jing Fu |
Solid phase sequencing of double-stranded nucleic acids
|
US7803529B1
(en)
*
|
1995-04-11 |
2010-09-28 |
Sequenom, Inc. |
Solid phase sequencing of biopolymers
|
US5750341A
(en)
*
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
US5830655A
(en)
|
1995-05-22 |
1998-11-03 |
Sri International |
Oligonucleotide sizing using cleavable primers
|
US5700642A
(en)
*
|
1995-05-22 |
1997-12-23 |
Sri International |
Oligonucleotide sizing using immobilized cleavable primers
|
US6027879A
(en)
*
|
1995-08-09 |
2000-02-22 |
The Regents Of The University Of California |
Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
|
US6146854A
(en)
*
|
1995-08-31 |
2000-11-14 |
Sequenom, Inc. |
Filtration processes, kits and devices for isolating plasmids
|
US5747255A
(en)
*
|
1995-09-29 |
1998-05-05 |
Lynx Therapeutics, Inc. |
Polynucleotide detection by isothermal amplification using cleavable oligonucleotides
|
US6849398B1
(en)
|
1996-01-18 |
2005-02-01 |
The Scripps Research Institute |
Use of encoded reaction cassette
|
CA2243989A1
(en)
*
|
1996-01-23 |
1997-07-31 |
Rapigene, Inc. |
Methods and compositions for detecting binding of ligand pair using non-fluorescent label
|
KR100482915B1
(ko)
*
|
1996-01-23 |
2005-09-12 |
퀴아진 지노믹스, 인코포레이티드 |
크기기술을사용하여핵산분자를분석하기위한방법및조성물
|
US6613508B1
(en)
*
|
1996-01-23 |
2003-09-02 |
Qiagen Genomics, Inc. |
Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
|
US6027890A
(en)
*
|
1996-01-23 |
2000-02-22 |
Rapigene, Inc. |
Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
|
US6312893B1
(en)
|
1996-01-23 |
2001-11-06 |
Qiagen Genomics, Inc. |
Methods and compositions for determining the sequence of nucleic acid molecules
|
EP0992511B1
(de)
*
|
1996-01-23 |
2009-03-11 |
Operon Biotechnologies, Inc. |
Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
|
CZ218498A3
(cs)
*
|
1996-01-23 |
1998-12-16 |
Rapigene, Inc. |
Způsoby a kompozice pro stanovení sekvence molekul nukleových kyselin
|
US20080160524A1
(en)
*
|
1996-01-24 |
2008-07-03 |
Third Wave Technologies, Inc. |
Methods and Compositions for Detecting Target Sequences
|
US7195871B2
(en)
*
|
1996-01-24 |
2007-03-27 |
Third Wave Technologies, Inc |
Methods and compositions for detecting target sequences
|
US6090606A
(en)
*
|
1996-01-24 |
2000-07-18 |
Third Wave Technologies, Inc. |
Cleavage agents
|
US7122364B1
(en)
|
1998-03-24 |
2006-10-17 |
Third Wave Technologies, Inc. |
FEN endonucleases
|
EP1634890B1
(de)
*
|
1996-01-24 |
2008-11-19 |
Third Wave Technologies, Inc. |
Invasive Spaltung von Nukleinsäuren
|
US7432048B2
(en)
*
|
1996-11-29 |
2008-10-07 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
US6706471B1
(en)
|
1996-01-24 |
2004-03-16 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
US7527928B2
(en)
*
|
1996-11-29 |
2009-05-05 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
US5985557A
(en)
|
1996-01-24 |
1999-11-16 |
Third Wave Technologies, Inc. |
Invasive cleavage of nucleic acids
|
US6875572B2
(en)
|
1996-01-24 |
2005-04-05 |
Third Wave Technologies, Inc. |
Nucleic acid detection assays
|
EP0885236A1
(de)
*
|
1996-01-26 |
1998-12-23 |
Codon Pharmaceuticals, Inc. |
Oligonukleotid-analoge
|
US5824478A
(en)
*
|
1996-04-30 |
1998-10-20 |
Vysis, Inc. |
Diagnostic methods and probes
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US6342349B1
(en)
*
|
1996-07-08 |
2002-01-29 |
Burstein Technologies, Inc. |
Optical disk-based assay devices and methods
|
AU725065B2
(en)
*
|
1996-07-08 |
2000-10-05 |
Burstein Technologies, Inc. |
Cleavable signal element device and method
|
US6780982B2
(en)
|
1996-07-12 |
2004-08-24 |
Third Wave Technologies, Inc. |
Charge tags and the separation of nucleic acid molecules
|
US5858665A
(en)
*
|
1996-07-25 |
1999-01-12 |
Navix, Inc. |
Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
|
US5853990A
(en)
|
1996-07-26 |
1998-12-29 |
Edward E. Winger |
Real time homogeneous nucleotide assay
|
US6352827B1
(en)
*
|
1996-08-28 |
2002-03-05 |
President And Fellows Of Harvard College |
Detection of multiple nucleic acid sequences in a fluid sample
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
ATE259056T1
(de)
|
1996-11-06 |
2004-02-15 |
Sequenom Inc |
Verfahren zur massenspektrometrie
|
CA2270132A1
(en)
*
|
1996-11-06 |
1998-05-14 |
Sequenom, Inc. |
Dna diagnostics based on mass spectrometry
|
US6133436A
(en)
*
|
1996-11-06 |
2000-10-17 |
Sequenom, Inc. |
Beads bound to a solid support and to nucleic acids
|
US6140053A
(en)
*
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
US6024925A
(en)
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
US7285422B1
(en)
*
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
US5900481A
(en)
*
|
1996-11-06 |
1999-05-04 |
Sequenom, Inc. |
Bead linkers for immobilizing nucleic acids to solid supports
|
CA2273204C
(en)
|
1996-11-29 |
2008-10-14 |
Third Wave Technologies, Inc. |
Fen-1 endonucleases, mixtures and cleavage methods
|
US6706473B1
(en)
|
1996-12-06 |
2004-03-16 |
Nanogen, Inc. |
Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
|
JP2001524808A
(ja)
*
|
1996-12-10 |
2001-12-04 |
ジーントレイス・システムズ・インコーポレイテッド |
放出可能な不揮発性の質量標識分子
|
US5905024A
(en)
*
|
1996-12-17 |
1999-05-18 |
University Of Chicago |
Method for performing site-specific affinity fractionation for use in DNA sequencing
|
PL335226A1
(en)
*
|
1997-02-21 |
2000-04-10 |
Burstein Lab |
Gene sequencer and related methods
|
US5846726A
(en)
*
|
1997-05-13 |
1998-12-08 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
WO1998053098A1
(de)
*
|
1997-05-21 |
1998-11-26 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Verfahren und kit zur detektion von mutationen in dna's mit hilfe von restriktionsenzymen
|
US5928869A
(en)
*
|
1997-05-30 |
1999-07-27 |
Becton, Dickinson And Company |
Detection of nucleic acids by fluorescence quenching
|
ATE240408T1
(de)
*
|
1997-07-22 |
2003-05-15 |
Qiagen Genomics Inc |
Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie
|
US6365731B1
(en)
|
1997-08-06 |
2002-04-02 |
Ambion, Inc. |
Stripping nucleic acids with iodine and sodium thiosulfate
|
US5955378A
(en)
*
|
1997-08-20 |
1999-09-21 |
Challener; William A. |
Near normal incidence optical assaying method and system having wavelength and angle sensitivity
|
US6207370B1
(en)
|
1997-09-02 |
2001-03-27 |
Sequenom, Inc. |
Diagnostics based on mass spectrometric detection of translated target polypeptides
|
US8182991B1
(en)
|
1997-11-26 |
2012-05-22 |
Third Wave Technologies, Inc. |
FEN-1 endonucleases, mixtures and cleavage methods
|
US6268131B1
(en)
|
1997-12-15 |
2001-07-31 |
Sequenom, Inc. |
Mass spectrometric methods for sequencing nucleic acids
|
GB9815163D0
(en)
*
|
1998-07-13 |
1998-09-09 |
Brax Genomics Ltd |
Compounds
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
WO1999040173A1
(fr)
*
|
1998-02-09 |
1999-08-12 |
Toyo Kohan Co., Ltd. |
Substrats d'immobilisation et d'amplification de l'adn, cristaux de blocage d'adn avec de l'adn bloque sur les substrats, et procede d'amplification de l'adn
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
US6607888B2
(en)
|
1998-10-20 |
2003-08-19 |
Wisconsin Alumni Research Foundation |
Method for analyzing nucleic acid reactions
|
US6221592B1
(en)
|
1998-10-20 |
2001-04-24 |
Wisconsin Alumi Research Foundation |
Computer-based methods and systems for sequencing of individual nucleic acid molecules
|
US20020025519A1
(en)
|
1999-06-17 |
2002-02-28 |
David J. Wright |
Methods and oligonucleotides for detecting nucleic acid sequence variations
|
US6201112B1
(en)
*
|
1999-07-22 |
2001-03-13 |
Agilent Technologies Inc. |
Method for 3′ end-labeling ribonucleic acids
|
US6528319B1
(en)
*
|
1999-09-02 |
2003-03-04 |
Amersham Biosciences Corp |
Method for anchoring oligonucleotides to a substrate
|
US7118860B2
(en)
|
1999-10-29 |
2006-10-10 |
Stratagene California |
Methods for detection of a target nucleic acid by capture
|
US6893819B1
(en)
*
|
2000-11-21 |
2005-05-17 |
Stratagene California |
Methods for detection of a nucleic acid by sequential amplification
|
US7838225B2
(en)
*
|
1999-10-29 |
2010-11-23 |
Hologic, Inc. |
Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
|
US7824859B2
(en)
*
|
1999-10-29 |
2010-11-02 |
Cytyc Corporation |
Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
|
JP2001204463A
(ja)
*
|
2000-01-27 |
2001-07-31 |
Toyo Kohan Co Ltd |
ヌクレオチド固定用担体
|
WO2001070685A2
(en)
*
|
2000-03-22 |
2001-09-27 |
Solulink, Incorporated |
Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
|
US8288322B2
(en)
*
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
JP5149476B2
(ja)
*
|
2000-04-17 |
2013-02-20 |
ダイアックス コーポレイション |
ペプチドの多種多様なファミリーのメンバーとしての、遺伝的パッケージの提示ライブラリーを構築する方法
|
ATE423221T1
(de)
|
2000-06-13 |
2009-03-15 |
Univ Boston |
Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
|
US20060057565A1
(en)
*
|
2000-09-11 |
2006-03-16 |
Jingyue Ju |
Combinatorial fluorescence energy transfer tags and uses thereof
|
US6627748B1
(en)
|
2000-09-11 |
2003-09-30 |
The Trustees Of Columbia University In The City Of New York |
Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
|
US7829348B2
(en)
*
|
2000-09-22 |
2010-11-09 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents and the use thereof
|
AU2002224336B2
(en)
|
2000-09-25 |
2007-01-04 |
Picoliter Inc. |
Acoustic ejection of fluids from a plurality of reservoirs
|
ATE432994T1
(de)
|
2000-09-26 |
2009-06-15 |
Boston Probes Inc |
Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
|
EP3034627B1
(de)
*
|
2000-10-06 |
2019-01-30 |
The Trustees of Columbia University in the City of New York |
Massives paralleles verfahren zum entschlüsseln von dna und rna
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
US20020142483A1
(en)
|
2000-10-30 |
2002-10-03 |
Sequenom, Inc. |
Method and apparatus for delivery of submicroliter volumes onto a substrate
|
EP1341929A2
(de)
*
|
2000-11-15 |
2003-09-10 |
Third Wave Technologies, Inc. |
Fen endonukleasen
|
JP4860098B2
(ja)
|
2000-12-18 |
2012-01-25 |
ダイアックス、コープ |
遺伝的パッケージの焦点を合わせたライブラリー
|
KR20020063359A
(ko)
*
|
2001-01-27 |
2002-08-03 |
일렉트론 바이오 (주) |
핵산 및 올리거뉴클레오티드의 상보적 이중결합의 특정서열에 특이적으로 반응하는 절단기법을 이용한 핵산 혼성분석 방법 및 장치
|
DK1373573T3
(da)
*
|
2001-03-09 |
2014-01-20 |
Trovagene Inc |
Konjugatsonder og optisk detektion af analytter
|
AU2013205033B2
(en)
*
|
2001-04-17 |
2016-06-09 |
Takeda Pharmaceutical Company Limited |
Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
|
US6534646B2
(en)
*
|
2001-06-04 |
2003-03-18 |
Barrskogen, Inc. |
Oligonucleotide labeling reagents
|
US6893822B2
(en)
|
2001-07-19 |
2005-05-17 |
Nanogen Recognomics Gmbh |
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
|
US20050147984A1
(en)
*
|
2001-08-31 |
2005-07-07 |
Clondiag Chip Technologies Gmbh |
Interaction detection on several probe arrays
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
WO2003054143A2
(en)
*
|
2001-10-25 |
2003-07-03 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
GB0129012D0
(en)
|
2001-12-04 |
2002-01-23 |
Solexa Ltd |
Labelled nucleotides
|
US7057026B2
(en)
*
|
2001-12-04 |
2006-06-06 |
Solexa Limited |
Labelled nucleotides
|
DE10201463B4
(de)
|
2002-01-16 |
2005-07-21 |
Clondiag Chip Technologies Gmbh |
Reaktionsgefäß zur Durchführung von Array-Verfahren
|
US7074597B2
(en)
*
|
2002-07-12 |
2006-07-11 |
The Trustees Of Columbia University In The City Of New York |
Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
|
US20040067532A1
(en)
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
ES2407681T3
(es)
|
2002-08-23 |
2013-06-13 |
Illumina Cambridge Limited |
Nucleótidos modificados para la secuenciación de polinucleótidos.
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
US11008359B2
(en)
|
2002-08-23 |
2021-05-18 |
Illumina Cambridge Limited |
Labelled nucleotides
|
EP1575990B1
(de)
*
|
2002-09-08 |
2009-11-18 |
Applera Corporation |
Festphasengebundene PNA-Dimere und deren Synthese
|
AU2003297859A1
(en)
*
|
2002-12-13 |
2004-07-09 |
The Trustees Of Columbia University In The City Of New York |
Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
|
BRPI0408967B8
(pt)
|
2003-03-31 |
2021-07-27 |
Hoffmann La Roche |
kit e métodos para detecção de um ácido nucléico de vários membros do sorogrupo do vírus da encefalite japonesa em uma amostra biológica sob condições de hibridização rigorosas
|
US7158353B2
(en)
*
|
2003-11-06 |
2007-01-02 |
Seagate Technology Llc |
Magnetoresistive sensor having specular sidewall layers
|
WO2005051967A2
(en)
*
|
2003-11-19 |
2005-06-09 |
Allelogic Biosciences Corp. |
Oligonucleotides labeled with a plurality of fluorophores
|
AU2005218507A1
(en)
*
|
2004-02-28 |
2005-09-15 |
Chang-Ning J. Wang |
Nucleic acid complexes
|
EP2436778A3
(de)
*
|
2004-03-03 |
2012-07-11 |
The Trustees of Columbia University in the City of New York |
Photospaltbare fluoreszierende Nukleotide zur DNA-Sequenzierung auf einem durch ortsspezifische Kopplungschemie konstruierten Chip
|
WO2006073436A2
(en)
*
|
2004-04-29 |
2006-07-13 |
The Trustees Of Columbia University In The City Of New York |
Mass tag pcr for multiplex diagnostics
|
US7939251B2
(en)
|
2004-05-06 |
2011-05-10 |
Roche Molecular Systems, Inc. |
SENP1 as a marker for cancer
|
WO2005118871A1
(en)
*
|
2004-05-28 |
2005-12-15 |
The Arizona Board Of Regents |
Surface plasmon resonance sensor for detecting changes in polynucleotides mass
|
US7828954B2
(en)
*
|
2004-09-21 |
2010-11-09 |
Gamida For Life B.V. |
Electrode based patterning of thin film self-assembled nanoparticles
|
ATE452208T1
(de)
*
|
2004-10-08 |
2010-01-15 |
Sysmex Corp |
Verfahren zum nachweis einer zielsubstanz unter verwendung einer nukleinsäuresonde
|
US20100029911A1
(en)
*
|
2004-11-24 |
2010-02-04 |
Aplagen Gmbh |
Method For Solid-Phase Peptide Synthesis And Purification
|
AU2006210553A1
(en)
|
2005-02-01 |
2006-08-10 |
Ab Advanced Genetic Analysis Corporation |
Reagents, methods and libraries for bead-based sequencing
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
WO2007002204A2
(en)
|
2005-06-21 |
2007-01-04 |
The Trustees Of Columbia University In The City Of New York |
Pyrosequencing methods and related compostions
|
GB0517097D0
(en)
|
2005-08-19 |
2005-09-28 |
Solexa Ltd |
Modified nucleosides and nucleotides and uses thereof
|
EP1957983A4
(de)
*
|
2005-11-21 |
2010-03-24 |
Univ Columbia |
Digitale multiplex-immunwahrnehmung unter verwendung einer bibliothek von photospaltbaren massen-tags
|
KR100652903B1
(ko)
*
|
2005-12-21 |
2006-12-04 |
한국과학기술연구원 |
초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
|
JP2009538123A
(ja)
*
|
2006-04-19 |
2009-11-05 |
アプライド バイオシステムズ, エルエルシー |
ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
|
US7674924B2
(en)
*
|
2006-05-22 |
2010-03-09 |
Third Wave Technologies, Inc. |
Compositions, probes, and conjugates and uses thereof
|
US8399188B2
(en)
|
2006-09-28 |
2013-03-19 |
Illumina, Inc. |
Compositions and methods for nucleotide sequencing
|
US7883869B2
(en)
|
2006-12-01 |
2011-02-08 |
The Trustees Of Columbia University In The City Of New York |
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
US20090017562A1
(en)
*
|
2007-03-13 |
2009-01-15 |
Iowa State University Research Foundation, Inc. |
Raman-active reagents
|
EP2193146B1
(de)
*
|
2007-09-14 |
2016-05-25 |
Adimab, LLC |
Synthetische antikörperbibliotheken mit rationalem design und ihre verwendung
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
WO2009039122A2
(en)
|
2007-09-17 |
2009-03-26 |
Sequenom, Inc. |
Integrated robotic sample transfer device
|
EP4310194A2
(de)
|
2007-10-19 |
2024-01-24 |
The Trustees of Columbia University in the City of New York |
Entwurf und synthese von spaltbaren fluoreszierenden nukleotiden als reversible terminatoren zur dna-sequenzierung durch synthese
|
US9115163B2
(en)
|
2007-10-19 |
2015-08-25 |
The Trustees Of Columbia University In The City Of New York |
DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
|
US20090215050A1
(en)
|
2008-02-22 |
2009-08-27 |
Robert Delmar Jenison |
Systems and methods for point-of-care amplification and detection of polynucleotides
|
US9873957B2
(en)
*
|
2008-03-13 |
2018-01-23 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR3 designs
|
KR101419980B1
(ko)
*
|
2008-03-15 |
2014-07-15 |
홀로직, 인크. |
증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법
|
EP2281078B1
(de)
|
2008-04-24 |
2014-10-22 |
Dyax Corporation |
Bibliotheken von genetischen packungen, umfassend neue hc-cdr1, -cdr2, und -cdr3, und neue lc-cdr1-, -cdr2- und -cdr3-designs
|
US8208909B2
(en)
|
2008-06-02 |
2012-06-26 |
West Corporation |
System, apparatus and method for availing a mobile call of address information
|
JP2013504602A
(ja)
*
|
2009-09-14 |
2013-02-07 |
ダイアックス コーポレーション |
新しく設計したhccdr3を含む遺伝子パッケージライブラリー
|
WO2011100561A1
(en)
*
|
2010-02-12 |
2011-08-18 |
Saint Louis University |
Molecular biosensors capable of signal amplification
|
AU2011242404B2
(en)
*
|
2010-04-23 |
2015-09-10 |
Australian Centre For Plant Functional Genomics Pty Ltd |
Tethered enzyme mediated nucleic acid detection
|
EP4219805A1
(de)
|
2010-07-16 |
2023-08-02 |
Adimab, LLC |
Antikörperbibliotheken
|
CN103119175B
(zh)
|
2010-09-20 |
2017-11-28 |
Seegene株式会社 |
在固相利用单一标记固定化探针及外切核酸活性的靶核酸序列检测
|
CA2835942C
(en)
|
2011-05-19 |
2019-01-22 |
Sequenom, Inc. |
Products and processes for multiplex nucleic acid identification
|
WO2014144883A1
(en)
|
2013-03-15 |
2014-09-18 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
DK2970356T3
(en)
|
2013-03-15 |
2018-08-27 |
Illumina Cambridge Ltd |
Modified nucleosides or nucleotides
|
ES2943498T3
(es)
|
2013-08-05 |
2023-06-13 |
Twist Bioscience Corp |
Genotecas sintetizadas de novo
|
WO2016126882A1
(en)
|
2015-02-04 |
2016-08-11 |
Twist Bioscience Corporation |
Methods and devices for de novo oligonucleic acid assembly
|
US9981239B2
(en)
|
2015-04-21 |
2018-05-29 |
Twist Bioscience Corporation |
Devices and methods for oligonucleic acid library synthesis
|
AU2016250841A1
(en)
|
2015-04-24 |
2017-11-02 |
Agena Bioscience, Inc. |
Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
|
CN107787371B
(zh)
|
2015-04-24 |
2022-02-01 |
基纳生物技术有限公司 |
检测和定量次要变体的并行式方法
|
GB2557529A
(en)
|
2015-09-18 |
2018-06-20 |
Twist Bioscience Corp |
Oligonucleic acid variant libraries and synthesis thereof
|
WO2017053450A1
(en)
|
2015-09-22 |
2017-03-30 |
Twist Bioscience Corporation |
Flexible substrates for nucleic acid synthesis
|
WO2017095958A1
(en)
|
2015-12-01 |
2017-06-08 |
Twist Bioscience Corporation |
Functionalized surfaces and preparation thereof
|
CN109996876A
(zh)
|
2016-08-22 |
2019-07-09 |
特韦斯特生物科学公司 |
从头合成的核酸文库
|
WO2018057526A2
(en)
*
|
2016-09-21 |
2018-03-29 |
Twist Bioscience Corporation |
Nucleic acid based data storage
|
WO2018066713A1
(ja)
*
|
2016-10-07 |
2018-04-12 |
地方独立行政法人神奈川県立産業技術総合研究所 |
核酸の検出方法及びそのためのキット
|
AU2017378492B2
(en)
|
2016-12-16 |
2022-06-16 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
US11550939B2
(en)
|
2017-02-22 |
2023-01-10 |
Twist Bioscience Corporation |
Nucleic acid based data storage using enzymatic bioencryption
|
CA3056388A1
(en)
|
2017-03-15 |
2018-09-20 |
Twist Bioscience Corporation |
Variant libraries of the immunological synapse and synthesis thereof
|
WO2018231872A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
WO2018231864A1
(en)
|
2017-06-12 |
2018-12-20 |
Twist Bioscience Corporation |
Methods for seamless nucleic acid assembly
|
SG11202002194UA
(en)
|
2017-09-11 |
2020-04-29 |
Twist Bioscience Corp |
Gpcr binding proteins and synthesis thereof
|
KR20240024357A
(ko)
|
2017-10-20 |
2024-02-23 |
트위스트 바이오사이언스 코포레이션 |
폴리뉴클레오타이드 합성을 위한 가열된 나노웰
|
KR20200106067A
(ko)
|
2018-01-04 |
2020-09-10 |
트위스트 바이오사이언스 코포레이션 |
Dna 기반 디지털 정보 저장
|
EP3814497A4
(de)
|
2018-05-18 |
2022-03-02 |
Twist Bioscience Corporation |
Polynukleotide, reagenzien und verfahren zur nukleinsäurehybridisierung
|
CN113785057A
(zh)
|
2019-02-26 |
2021-12-10 |
特韦斯特生物科学公司 |
用于抗体优化的变异核酸文库
|
CA3131689A1
(en)
|
2019-02-26 |
2020-09-03 |
Twist Bioscience Corporation |
Variant nucleic acid libraries for glp1 receptor
|
AU2020298294A1
(en)
|
2019-06-21 |
2022-02-17 |
Twist Bioscience Corporation |
Barcode-based nucleic acid sequence assembly
|