DE3587477T2 - Verfahren zur radioaktiven Markierung von diagnostischen und therapeutischen Agenzien die eine Chelatierungsgruppe enthalten. - Google Patents
Verfahren zur radioaktiven Markierung von diagnostischen und therapeutischen Agenzien die eine Chelatierungsgruppe enthalten.Info
- Publication number
- DE3587477T2 DE3587477T2 DE85100899T DE3587477T DE3587477T2 DE 3587477 T2 DE3587477 T2 DE 3587477T2 DE 85100899 T DE85100899 T DE 85100899T DE 3587477 T DE3587477 T DE 3587477T DE 3587477 T2 DE3587477 T2 DE 3587477T2
- Authority
- DE
- Germany
- Prior art keywords
- radioactive metal
- binding affinity
- metal ion
- diagnostic agent
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000032 diagnostic agent Substances 0.000 title abstract 5
- 229940039227 diagnostic agent Drugs 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 5
- 229940124597 therapeutic agent Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000009920 chelation Effects 0.000 title 1
- 238000000163 radioactive labelling Methods 0.000 title 1
- 230000002285 radioactive effect Effects 0.000 abstract 6
- 229910021645 metal ion Inorganic materials 0.000 abstract 5
- 230000001225 therapeutic effect Effects 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229910052755 nonmetal Inorganic materials 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/575,397 US4707352A (en) | 1984-01-30 | 1984-01-30 | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3587477D1 DE3587477D1 (de) | 1993-09-02 |
| DE3587477T2 true DE3587477T2 (de) | 1994-02-17 |
Family
ID=24300158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE85100899T Expired - Lifetime DE3587477T2 (de) | 1984-01-30 | 1985-01-29 | Verfahren zur radioaktiven Markierung von diagnostischen und therapeutischen Agenzien die eine Chelatierungsgruppe enthalten. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US4707352A (de) |
| EP (1) | EP0150844B1 (de) |
| JP (1) | JPH0822822B2 (de) |
| AT (1) | ATE92190T1 (de) |
| AU (1) | AU597208B2 (de) |
| CA (1) | CA1256023A (de) |
| DE (1) | DE3587477T2 (de) |
| DK (1) | DK39985A (de) |
| ES (1) | ES8704001A1 (de) |
| IL (1) | IL74187A (de) |
| NO (1) | NO850353L (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175269A (en) * | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
| US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US5001072A (en) * | 1984-05-23 | 1991-03-19 | Icn Biomedicals Inc. | Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels |
| US4898724A (en) * | 1984-06-04 | 1990-02-06 | The Dow Chemical Company | Organis amine phosphonic acid complexes for the treatment of calcific tumors |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4707544A (en) * | 1984-11-28 | 1987-11-17 | President And Fellows Of Harvard College | Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents |
| CA1293729C (en) * | 1985-08-05 | 1991-12-31 | Alan Purdom Carpenter Jr | Metal-isonitrile adducts for preparing radionuclide complexes |
| US4894445A (en) * | 1985-08-05 | 1990-01-16 | E. I. Du Pont De Nemours And Company | Metal-isonitrile adducts for preparing radionuclide complexes |
| US5155216A (en) * | 1985-08-15 | 1992-10-13 | Amoco Corporation | Nucleic acids labeled with a chemiluminescent acridine ester |
| US5336762A (en) * | 1985-11-18 | 1994-08-09 | Access Pharmaceuticals, Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| JP3293820B2 (ja) * | 1985-12-13 | 2002-06-17 | エンゾ− バイオケム インコ−ポレイテツド | 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物 |
| US4831122A (en) * | 1986-01-09 | 1989-05-16 | Regents Of The University Of Minnesota | Radioimmunotoxins |
| AU593611B2 (en) * | 1986-02-14 | 1990-02-15 | Nihon Medi-Physics Co., Ltd. | High molecular compounds having amino groups, and their utilization |
| US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
| US6673347B1 (en) * | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| US5011959A (en) * | 1986-11-17 | 1991-04-30 | The Board Of Regents, The University Of Texas System | 1,2-diaminocyclohexane-platinum complexes with antitumor activity |
| AU619218B2 (en) * | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| WO1989005853A1 (en) * | 1987-12-15 | 1989-06-29 | Synthetic Genetics | Nucleic acid chelate conjugate as therapeutic and diagnostic agents |
| EP0325559B1 (de) * | 1988-01-20 | 1993-12-15 | Ciba-Geigy Ag | Verfahren zur Herstellung von Komplexverbindungen |
| US6326136B1 (en) | 1988-04-01 | 2001-12-04 | Digene Corporation | Macromolecular conjugate made using unsaturated aldehydes |
| WO1989009780A1 (en) * | 1988-04-15 | 1989-10-19 | Chemical Industry Institute Of Toxicology | Site-specific tritium-labeled oligodeoxynucleotides |
| EP0339389B1 (de) * | 1988-04-25 | 1993-09-22 | F. Hoffmann-La Roche Ag | Diagnose-Hilfsmittel |
| US5059541A (en) * | 1988-04-29 | 1991-10-22 | Neorx Corporation | Minimal derivatization of proteins |
| US4917878A (en) * | 1988-05-02 | 1990-04-17 | Thomas Jefferson University | Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals |
| JPH04501265A (ja) * | 1988-10-14 | 1992-03-05 | マリンクロッド・インコーポレイテッド | ラジオ標識粒状組成物 |
| US5393909A (en) * | 1988-11-22 | 1995-02-28 | Board Of Regents, The University Of Texas System | Diamine platinum complexes as antitumor agents |
| GR1002475B (el) * | 1988-12-05 | 1996-11-26 | Novartis Ag (Novartis Sa) (Novartis Inc.) | Μεθοδος παρασκευης πεπτιδικων παραγωγων. |
| MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
| US5612019A (en) * | 1988-12-19 | 1997-03-18 | Gordon, Deceased; David | Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles |
| US5998135A (en) * | 1989-02-24 | 1999-12-07 | Enzo Diagnostics, Inc. | Energy transfer hybridization assay using intercalators and lanthanide metals |
| US5244816A (en) * | 1989-10-11 | 1993-09-14 | Akzo N.V. | Method for purifying chelator conjugated compounds |
| EP0593452A1 (de) * | 1989-11-30 | 1994-04-27 | Mallinckrodt Medical, Inc. | Verfahren zur herstellung eines mit metallradionuklid markierten proteins |
| US5264343A (en) * | 1990-08-31 | 1993-11-23 | Eleanor Roosevelt Institute | Method for distinguishing normal and cancer cells |
| US5122363A (en) * | 1990-12-07 | 1992-06-16 | Board Of Regents, The University Of Texas System | Zeolite-enclosed transistion and rare earth metal ions as contrast agents for the gastrointestinal tract |
| US5578704A (en) * | 1992-04-03 | 1996-11-26 | Genentech, Inc. | Antibody to osteoclast alphavbeta3 ntegrin |
| US5292938A (en) * | 1992-04-13 | 1994-03-08 | Associated Universities, Inc. | Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
| US5279937A (en) * | 1992-04-30 | 1994-01-18 | Detechnology Canada | Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays |
| US7713528B1 (en) | 1993-02-18 | 2010-05-11 | Enzo Therapeutics, Inc. | Method for in vivo delivery of active compounds using reagent conjugate |
| DE69423753T2 (de) | 1993-05-05 | 2000-11-02 | Keith Rose | Polyoximverbindungen und deren herstellung |
| US6001364A (en) * | 1993-05-05 | 1999-12-14 | Gryphon Sciences | Hetero-polyoxime compounds and their preparation by parallel assembly |
| US6174530B1 (en) | 1993-05-05 | 2001-01-16 | Gryphon Sciences | Homogeneous polyoxime compositions and their preparation by parallel assembly |
| US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5824473A (en) * | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| CA2179990A1 (en) * | 1994-01-12 | 1995-07-20 | Gary Robert Bower | Biological targeting agents |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US5556939A (en) * | 1994-10-13 | 1996-09-17 | Merck Frosst Canada, Inc. | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications |
| US5632969A (en) * | 1994-10-13 | 1997-05-27 | Merck & Co., Inc. | N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications |
| WO1996015653A2 (en) * | 1994-11-04 | 1996-05-30 | The Immune Response Corporation | Vial retainer |
| US5648268A (en) * | 1994-12-06 | 1997-07-15 | Ibm Corporation | Radionuclide exchange detection of ultra trace ionic impurities in water |
| US20050025740A1 (en) * | 1996-01-05 | 2005-02-03 | Keith Rose | Polyoxime compounds and their preparation |
| US6736769B2 (en) | 1996-04-17 | 2004-05-18 | Olivier Bertrand | Radioactivity local delivery system |
| US6444423B1 (en) | 1996-06-07 | 2002-09-03 | Molecular Dynamics, Inc. | Nucleosides comprising polydentate ligands |
| US7393645B2 (en) * | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US6096273A (en) * | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7014992B1 (en) * | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
| US7045285B1 (en) * | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
| US7160678B1 (en) | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US7381525B1 (en) | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| CA2319170A1 (en) | 1998-01-27 | 1999-07-29 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| US6686150B1 (en) | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| US6214301B1 (en) | 1998-03-27 | 2001-04-10 | The Regents Of The University Of California | Hafnium radioisotope recovery from irradiated tantalum |
| US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| US6761816B1 (en) | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
| US7087148B1 (en) | 1998-06-23 | 2006-08-08 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
| US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| AU1241000A (en) | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| US6833267B1 (en) | 1998-12-30 | 2004-12-21 | Clinical Micro Sensors, Inc. | Tissue collection devices containing biosensors |
| MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US7312087B2 (en) | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| EP1218541B1 (de) | 1999-07-26 | 2008-12-10 | Clinical Micro Sensors, Inc. | Nukelinsäuresequenzbestimmung mittels elektronischem nachweis |
| US6753143B2 (en) | 2000-05-01 | 2004-06-22 | Clinical Micro Sensors, Inc. | Target analyte detection using asymmetrical self-assembled monolayers |
| JP4382265B2 (ja) * | 2000-07-12 | 2009-12-09 | 日本電気株式会社 | 酸化シリコン膜の形成方法及びその形成装置 |
| WO2007128873A1 (en) * | 2006-05-05 | 2007-11-15 | Wallac Oy | A method for the preparation of maleimido derivatives of biomolecule labeling reactants and conjugates derived thereof |
| US8150101B2 (en) | 2006-11-13 | 2012-04-03 | Cybernet Systems Corporation | Orientation invariant object identification using model-based image processing |
| DE102007002726A1 (de) | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| CA2720511A1 (en) | 2008-04-01 | 2009-10-08 | Biosearch Technologies, Inc. | Stabilized nucleic acid dark quencher-fluorophore probes |
| US10519485B2 (en) | 2015-04-15 | 2019-12-31 | Biosearch Technologies, Inc. | Dual quencher probes |
| WO2023018805A1 (en) | 2021-08-11 | 2023-02-16 | Sanofi Pasteur Inc. | Methods and related aspects of detecting and purifying influenza neuraminidase |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3936440A (en) * | 1974-05-22 | 1976-02-03 | Drexel University | Method of labeling complex metal chelates with radioactive metal isotopes |
| FR2281134A1 (fr) * | 1974-08-06 | 1976-03-05 | Commissariat Energie Atomique | Procede de marquage au 99m technetium |
| US4043998A (en) * | 1974-10-09 | 1977-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid |
| US4272503A (en) * | 1978-05-25 | 1981-06-09 | New England Nuclear Corporation | Reductant composition for technetium-99m and method for making technetium-99m labelled ligands |
| US4305922A (en) * | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
| US4320109A (en) * | 1979-06-29 | 1982-03-16 | The University Of Southern California | Immunoradiometric assay employing terminal radionuclide labeling and synthesis of conjugates for such assay |
| US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
| CA1222691A (en) * | 1981-12-29 | 1987-06-09 | Wilhelmus T. Goedemans | Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments |
| GB2122641B (en) * | 1982-06-07 | 1986-08-06 | Otto A Gansow | Metal chelate conjugated monoclonal antibodies where in the metal is an emitter |
| US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| US4652519A (en) * | 1983-02-03 | 1987-03-24 | Yeda Research And Development Company Limited | Bifunctional chelating agents and process for their production |
| JPS59199636A (ja) * | 1983-04-26 | 1984-11-12 | Nippon Mejifuijitsukusu Kk | 放射性診断剤 |
| US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| US4672028A (en) * | 1984-05-23 | 1987-06-09 | Icn Micromedic Systems, Inc. | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels |
-
1984
- 1984-01-30 US US06/575,397 patent/US4707352A/en not_active Expired - Lifetime
-
1985
- 1985-01-25 CA CA000472895A patent/CA1256023A/en not_active Expired
- 1985-01-29 AT AT85100899T patent/ATE92190T1/de not_active IP Right Cessation
- 1985-01-29 ES ES539927A patent/ES8704001A1/es not_active Expired
- 1985-01-29 NO NO850353A patent/NO850353L/no unknown
- 1985-01-29 DE DE85100899T patent/DE3587477T2/de not_active Expired - Lifetime
- 1985-01-29 DK DK39985A patent/DK39985A/da not_active Application Discontinuation
- 1985-01-29 EP EP85100899A patent/EP0150844B1/de not_active Expired - Lifetime
- 1985-01-29 IL IL74187A patent/IL74187A/xx unknown
- 1985-01-30 AU AU38213/85A patent/AU597208B2/en not_active Ceased
- 1985-01-30 JP JP60014635A patent/JPH0822822B2/ja not_active Expired - Lifetime
-
1987
- 1987-01-23 US US07/006,819 patent/US4772548A/en not_active Expired - Lifetime
- 1987-01-23 US US07/006,818 patent/US4767609A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES539927A0 (es) | 1987-03-01 |
| DE3587477D1 (de) | 1993-09-02 |
| EP0150844A3 (en) | 1988-05-04 |
| ATE92190T1 (de) | 1993-08-15 |
| EP0150844B1 (de) | 1993-07-28 |
| AU597208B2 (en) | 1990-05-24 |
| NO850353L (no) | 1985-07-31 |
| US4772548A (en) | 1988-09-20 |
| DK39985A (da) | 1985-07-31 |
| DK39985D0 (da) | 1985-01-29 |
| JPS60178827A (ja) | 1985-09-12 |
| EP0150844A2 (de) | 1985-08-07 |
| CA1256023A (en) | 1989-06-20 |
| IL74187A (en) | 1989-03-31 |
| US4707352A (en) | 1987-11-17 |
| AU3821385A (en) | 1985-08-08 |
| US4767609A (en) | 1988-08-30 |
| ES8704001A1 (es) | 1987-03-01 |
| JPH0822822B2 (ja) | 1996-03-06 |
| IL74187A0 (en) | 1985-04-30 |
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|---|---|---|---|
| 8364 | No opposition during term of opposition |