DE2853614A1 - IMPLANT - Google Patents

IMPLANT

Info

Publication number
DE2853614A1
DE2853614A1 DE19782853614 DE2853614A DE2853614A1 DE 2853614 A1 DE2853614 A1 DE 2853614A1 DE 19782853614 DE19782853614 DE 19782853614 DE 2853614 A DE2853614 A DE 2853614A DE 2853614 A1 DE2853614 A1 DE 2853614A1
Authority
DE
Germany
Prior art keywords
carbon
substrate
implant
implant according
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782853614
Other languages
German (de)
Inventor
Donald A Raible
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Hospital Supply Corp
Original Assignee
Bentley Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bentley Laboratories Inc filed Critical Bentley Laboratories Inc
Publication of DE2853614A1 publication Critical patent/DE2853614A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/062Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/443Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers

Description

HOFFMANN - EITiIL Sl PARTNER 2 θ S 3 6 1 AHOFFMANN - EITiIL Sl PARTNER 2 θ S 3 6 1 A

PATENTANWÄLTEPATENT LAWYERS

DR. ING. E. HOFFMANN (1930-1976) · DIPL.-I N G. W.EIUE . DR. RER. NAT. K. HOFFMAN N · DIPL.-ING. W. LEH NDR. ING. E. HOFFMANN (1930-1976) DIPL.-I N G. W. EIUE. DR. RER. NAT. K. HOFFMAN N DIPL.-ING. W. LEH N

DIPL.-ING. K. FDCHSLE · DR. RER. NAT. B. HANSEN ARABELLASTRASSE 4 (STERN HAUS) · D-8000 MO NCHEN 81 · TELEFON (089) 9Π087 · TELEX 05-29619 (PATH E)DIPL.-ING. K. FDCHSLE DR. RER. NAT. B. HANSEN ARABELLASTRASSE 4 (STERN HAUS) D-8000 MO NCHEN 81 TELEPHONE (089) 9Π087 TELEX 05-29619 (PATH E)

• 31 488 o/fi• 31 488 o / fi

BENTLEY LABORATORIES, Inc. Irvine, Calif./USA .BENTLEY LABORATORIES, Inc. Irvine, Calif./USA.

ImplantatImplant

Die Erfindung betrifft ein Implantat aus einem biokompaktiblen Kohlenstoffstubstrat, welches mit Collagen beschichtet ist. Ein solches Implantat kann als Hautgewebe bildendes Substrat oder als ein Ersatz für Hautgewebe oder Blutgefäße verwendet werden. Das Implantat kann auch zum Bedecken von implantierbaren prothetischen Artikeln oder zum Verschließen von Hautgewebe über Implante verwendet werden.The invention relates to an implant made of a biocompactable Carbon substrate coated with collagen is. Such an implant can be used as a skin tissue-forming substrate or as a replacement for skin tissue or blood vessels are used. The implant can also be used to cover implantable prosthetic articles or used to close skin tissue over implants will.

Es gibt eine Reihe von Situationen, bei denen es erforderlich, eine Fluidverbindung zwischen einem Körperorgan oder einem vaskulären System zu bilden. Beispielsweise benötigen an Nierenversagen leidende Patienten eine Blutdialyse mittels außerhalb des Körpers arbeitender Vorrichtungen. Blut, das toxische Substanzen, wie Harnstoff, Harnsäure, Kreatin, Phosphor und Calcium enthält, muß aus dem Blutsystem entfernt, behandelt und dann dem Patienten wieder zugeführtThere are a number of situations in which there is a need to have fluid communication between a body organ or body to form a vascular system. For example, patients suffering from kidney failure require hemodialysis by means of devices operating outside the body. Blood containing toxic substances such as urea, uric acid, creatine, Containing phosphorus and calcium must be removed from the blood system, treated and then returned to the patient

9 09830/05999 09830/0599

28538142853814

werden. Patienten, die eine solche Blutdialyse benötigen, müssen wenigstens zwei- bis dreimal pro Woche behandelt werden. Unter Hypoalimentation leidende Patienten benötigen eine Vorrichtung, mittels welcher man zumindest täglich Zutritt zum vaskulärem System des Körpers erhält.will. Patients who need such hemodialysis must be treated at least two to three times a week will. Patients suffering from hypoalimentation need a device by means of which one can at least daily Gaining access to the body's vascular system.

Weiterhin gibt es zahlreiche Situationen, bei denen es erforderlich ist, eine Enterostomie vorzunehmen. Bei dieser Operation muß ein inneres Gefäßorgan mit der Außenwelt verbunden werden. Die häufigsten Gefäße oder Organe, bei denen eine Verbindung nach außen hergestellt werden muß, sind Ileum, Colon, Ureter, Urethra und die Blase und Pelvis oder die Niere. Eine Enterostomie kann durchgeführt werden, indem man eine Röhre zwischen der Wand des nach außen zu führenden Organs bildet und dann die Gefäßwand an die Röhre durch eine Öffnung näht, die an der Oberfläche des Körpers gebildet wurde. Im allgemeinen wächst die Gefäßwandunq und die Dermis der die Öffnung umschliessenden Haut zusammen, so daß das Gefäß permanent an die Oberfläche des Körpers befestigt ist. Ein Implantat kann bei der Enterostomie verwendet werden,um die aus dem nach außen führenden Gefäß oder Organ sich abscheidenden Exkremente von einem Oberflächenkontakt mit der Haupt zu bewahren.There are also numerous situations in which it is necessary to perform an enterostomy. At this Operation, an internal vascular organ must be connected to the outside world. The most common vessels or organs that need to be connected to the outside world are the ileum, colon, ureter, urethra and the bladder and pelvis or the kidney. An enterostomy can be done by putting a tube between the wall of the organ to be led to the outside and then sews the vessel wall to the tube through an opening that is at the Surface of the body was formed. In general, the vessel wall and the dermis surrounding the opening grow Skin together so that the vessel is permanently attached to the surface of the body. An implant can used in enterostomy to remove the excrement from the vessel or organ leading to the outside to keep from surface contact with the head.

Schließlich gibt es viele Fälle, wo ein Teil eines Körpers rekonstruiert werden muß, einschließlich der Bildung von künstlichen Blutgefäßen und Geweben.Finally, there are many cases where part of a body needs to be reconstructed, including the formation of artificial blood vessels and tissues.

Die Erfindung betrifft ein Implantat aus einem biokompaktiblen Kohlenstoffsubstrat, wobei das Substrat zumindest außen mit Collagen beschichtet ist. In einer bevorzugten Ausführungsform besteht das Kohlenstoffsubstrat aus einer Anzahl Kohlenstoffäden, die in überlappenden Orientierung angeordnet sind unter Ausbildung einer faserförmigen vlies-The invention relates to an implant made from a biocompactable carbon substrate, the substrate at least is coated with collagen on the outside. In a preferred embodiment, the carbon substrate consists of one Number of carbon threads that are arranged in an overlapping orientation with the formation of a fibrous fleece

- 5 909830/0599 - 5 909830/0599

artigen Struktur. Die Kohlenstoffäden werden mittels eines Binders" aus Collagen zusammengehalten. Der Kohlenstoff ist vorzugsweise entweder eine pyrolytischer Kohlenstoff auf einem Graphitsubstrat oder glasförmiger Kohlenstoff. like structure. The carbon threads are by means of a binder "made of collagen. The carbon is preferably either a pyrolytic carbon on a graphite substrate or glassy carbon.

Die Einzelheiten der Erfindung werden nun unter Bezugnahme auf die Zeichnungen erläutert.The details of the invention will now be explained with reference to the drawings.

Fig. 1 stellt eine perspektivische Aufsicht qemäß einer Ausführungsform der Erfindung dar, undFig. 1 shows a perspective plan view qemäß an embodiment of the invention, and

Fig. 2 ist eine perspektivische Aufsicht gemäß einer anderen Ausführungsform der Erfindung.2 is a top perspective view according to another embodiment of the invention.

Collagen ist ein Naturprodukt. Es ist einer der Hauptbestandteile der Haut, der Sehnen, der Knorpel und der Knochen. Sein Molekularaufbau ist untersucht worden und .ist bekannt. Die Collagenstruktur ist dadurch gekennzeichnet, daß sie einen hohen Anteil an Prolin und Hydroxyprolinresten enthält, und daß sie in häufiger Wiederholung die Sequenz GIyζin, Prolin, Hydroxyprolin aufweist.Collagen is a natural product. It is one of the main components of the skin, tendons, and cartilage Bone. Its molecular structure has been investigated and is known. The collage structure is characterized by that it contains a high proportion of proline and hydroxyproline residues, and that it is repeated frequently has the sequence GIyζin, proline, hydroxyproline.

H2 HO-CHH 2 HO-CH

2**· /^η t-u')n ^2 ** · / ^ η t - u ') n ^

H~Ö .CH-H ~ Ö .CH-

NH
Prolin Hydroxyprolin
NH
Proline hydroxyproline

Collacran hat eine helixartige Struktur der alpha-Proteine mit einer Wasserstoffbindung zwischen den Ketten der beta-Proteine. Die drei Ketten werden durch die Wasserstoff-Collacran has a helical structure of the alpha proteins with a hydrogen bond between the chains of beta proteins. The three chains are formed by the hydrogen

909830/0599909830/0599

O "O "

28538H28538H

bindung zwischen den Glyzinresten und zwischen den -OH-Gruppen des Hydroxyprolins fest zusammengehalten.(S. hierzu Morrison and Boyd, Organic Chemistry, Kapitel 36, Aminosäuren und Proteine (3. Auflage, 1973)).bond between the glycine residues and between the -OH groups of the hydroxyproline firmly held together Morrison and Boyd, Organic Chemistry, Chapter 36, Amino Acids and Proteins (3rd Edition, 1973)).

In Fig. 1 wird eine Vielzahl von Kohlenstoffäden 1 gezeigt, die orientiert und überlappend unter Ausbildung einer faserartigen vliesartigen Struktur angeordnet sind. Das Kohlenstoffsubstrat ist entweder ein pyrolytischer Kohlenstoff auf einem Graphitsubstrat oder glasförmiger Kohlenstoff. Die Kohlenstoffäden werden durch das Collagen 3 zusammengehalten .In Fig. 1 a plurality of carbon threads 1 is shown, which are oriented and arranged overlapping to form a fiber-like fleece-like structure. The carbon substrate is either a pyrolytic carbon on a graphite substrate or vitreous carbon. The carbon threads are held together by the collagen 3 .

Fig. 2 zeigt eine andere erfindungsgemäße Ausführungsform in welcher ein Kohlenstoffsubstrat mit Collagen 3 beschichtet ist. Das Implantat gemäß Fig. 2 hat einen kreisförmigen Teil 7 um eine Öffnung 5.Fig. 2 shows another embodiment of the invention in which a carbon substrate is coated with 3 collagen is. The implant according to FIG. 2 has a circular part 7 around an opening 5.

Es ist in Aussicht genommen, daß das Implantat von der Art gemäß Fig. 1 und 2 als Gewebepfropfsubstrat verwendet werden kann, bei dem das Gewebe an das collagengebundene Kohlenstoff substrat gebunden wird. Gemäß anderen Ausführungsformen kann das Implantat als künstliches Blutgefäß oder als Gewebeersatz verwendet werden. Das erfinduhgsgemäße Implantat kann auch zum Bedecken von implantierbaren prothetischen Vorrichtungen verwendet werden, und stellt dabei sowohl die Bindung an das Gewebe als auch die Abdeckung des Gewebes gegenüber dem Implantat dar.It is envisaged that the implant of the type shown in Figures 1 and 2 will be used as a tissue graft substrate in which the tissue is bound to the collagen-bound carbon substrate. According to other embodiments the implant can be used as an artificial blood vessel or as a tissue replacement. The inventive implant can also be used to cover implantable prosthetic devices, providing both the bond to the tissue as well as the covering of the tissue opposite the implant.

Für den Fachmann ist es ersichtlich, daß zahlreiche Modifizierungen durchgeführt werden könne, ohne vom erfinderischen Konzept abzuweichen.It will be apparent to those skilled in the art that numerous modifications can be performed without departing from the inventive concept.

909830/0599909830/0599

Claims (5)

HOFFMAN>7 - 2SITTJt. & PAKTNER 28 5 3614 PAT E N TAN WALT E DR. ING. E. HOFFMANN (1930-1976) · Dl Pl.-I N G. W.EITLE · 0 R. RER. NAT. K. HOFFMAN N . DI PL.-I N G. W. LEH N D I PL.-I NG. K. FDCHSLE · DR. RER. NAT. B. HANSEN ARABELLASTRASSE 4 (STERN HAUS) · D-8000 MO NCH EN 81 · TELEFON (0S9) 911087 · TELEX 05-29619 (PATH E) 31 488 o/fi BENTLEY LABORATORIES, Inc. Irvine, Calif./USA ' Implantat Patentansprüche tHOFFMAN> 7 - 2SITTJt. & PAKTNER 28 5 3614 PAT E N TAN WALT E DR. ING. E. HOFFMANN (1930-1976) Dl Pl.-I N G. W.EITLE 0 R. RER. NAT. K. HOFFMAN N. DI PL.-I N G. W. LEH N D I PL.-I NG. K. FDCHSLE DR. RER. NAT. B. HANSEN ARABELLASTRASSE 4 (STERN HAUS) D-8000 MO NCH EN 81 TELEPHONE (0S9) 911087 TELEX 05-29619 (PATH E) 31 488 o / fi BENTLEY LABORATORIES, Inc. Irvine, Calif./USA 'Implant Claims t 1. Implantat, gekennzeichnet durch ein biokompatibles Kohlenstoffsubstrat, das zumindestens äuerßlich mit Collagen beschichtet ist.1. Implant, characterized by a biocompatible carbon substrate, which is at least is externally coated with collagen. 2. Implantat gemäß Anspruch 1, dadurch gekennzeichnet , daß das biokompatible Substrat aus einer Vielzahl von Kohlenstofffaden besteht und die Cdlagenbeschichtung die Kohlenstoffäden bindet.2. Implant according to claim 1, characterized that the biocompatible substrate consists of a plurality of carbon filaments and the Cd layer coating binds the carbon threads. 3. Implantat gemäß Anspruch 2, dadurch gekennzeichnet , daß die Kohlenstoffäden in einer im wesentlichen überlappenden Orientierung unter Ausbildung einer faserartigen Vließstruktur angeordnet sind, und daß der Collagenbinder im wesentlichen alle3. Implant according to claim 2, characterized that the carbon threads in arranged in a substantially overlapping orientation to form a fiber-like nonwoven structure and that the collagen binder is essentially all 909830/0599 -2-909830/0599 -2- ORlGlNAt INSPECTEDORlGlNAt INSPECTED 28536U28536U _ 2 —_ 2 - Zwischenräume zwischen den überlappenden Kohlenstofffaden bedeckt.'Gaps between the overlapping carbon filaments covered.' 4. Implantat gemäß Ansprüchen 2 oder 3, dadurch gekennzeichnet , daß das Substrat im wesentlichen unporös und nichtbioabbaufahig ist.4. Implant according to claims 2 or 3, characterized characterized in that the substrate is substantially non-porous and non-biodegradable. 5. Implantat gemäß Ansprüche 1 bis 4r dadurch gekennzeichnet , daß das Substrat gebildet ist aus einem Material aus der Gruppe pyrolytxscher Kohlenstoff auf einem graphischen Substrat und glasartiger Kohlenstoff. 5. The implant according to claims 1 to 4, r characterized in that the substrate is formed of a material selected from the group pyrolytxscher carbon on a photographic substrate, and glassy carbon. 909830/0599909830/0599
DE19782853614 1978-01-25 1978-12-12 IMPLANT Withdrawn DE2853614A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87224178A 1978-01-25 1978-01-25

Publications (1)

Publication Number Publication Date
DE2853614A1 true DE2853614A1 (en) 1979-07-26

Family

ID=25359139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782853614 Withdrawn DE2853614A1 (en) 1978-01-25 1978-12-12 IMPLANT

Country Status (6)

Country Link
JP (1) JPS54119798A (en)
BR (1) BR7900377A (en)
CA (1) CA1118155A (en)
DE (1) DE2853614A1 (en)
FR (1) FR2415456A1 (en)
GB (1) GB2014475B (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204700A1 (en) * 1981-02-12 1982-09-02 Mitsubishi Chemical Industries, Ltd., Tokyo ARTIFICIAL PROSTHESIC MATERIAL ON A CARBON BASE
US4699141A (en) * 1986-01-16 1987-10-13 Rhode Island Hospital Neovascularization
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5759830A (en) * 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5770417A (en) * 1986-11-20 1998-06-23 Massachusetts Institute Of Technology Children's Medical Center Corporation Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US7914579B2 (en) 1995-05-01 2011-03-29 Children's Medical Center Corporation Tissue engineered tendons and ligaments

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510394A1 (en) * 1981-07-30 1983-02-04 Ceraver Ligament or tendon prosthesis stimulating tissue regrowth - comprises fibrous material, e.g. carbon fibres, coated with collagen
FR2511249A1 (en) * 1981-08-14 1983-02-18 Bentley Lab Implant for fluid passage - fitted with anchorage and netting made of pyrolysis carbon on graphite substrate
JPH0669741B2 (en) * 1985-01-16 1994-09-07 東レ株式会社 Sheet
JP2799596B2 (en) * 1989-08-10 1998-09-17 株式会社ジェイ・エム・エス Bioimplant device and method for producing the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185332B (en) * 1961-03-01 1965-01-14 Ethicon Inc Surgical prosthesis
DE1902700A1 (en) * 1969-01-17 1970-08-20 Carlton Sports Company Ltd Artificial bones and joints for the human - body
DE1566319B1 (en) * 1966-10-19 1970-10-15 Ethicon Inc Implant
DE2017330A1 (en) * 1970-04-10 1971-12-09 BIO-CAL Instrument GmbH, 8032 Gräfelfing Blood vessel connector - for artificial kidneys or lungs
DE1494939B2 (en) * 1963-06-11 1972-03-02 Buddecke, Eckhart, Prof Dr , 4400 Munster Implantation material for prostheses for the replacement of arteries and other pathways and hollow organs containing body juices and processes for the production thereof
DE1491218B2 (en) * 1963-06-15 1972-06-08 Spofa Sdruzheni Podniku Pro Zdravotnickou Vyrobu, Prag Blood vessel prosthesis and method of making the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1165698A (en) * 1965-11-05 1969-10-01 Guinness De Laszlo M A P Henry Improvements in or relating to Prostheses
CS148134B1 (en) * 1970-11-20 1973-02-22
SE393290B (en) * 1971-05-20 1977-05-09 Vitek Inc MATERIAL COMPOSITION FOR USE FOR IMPLANTATION IN VIVO, WHICH COMPOSITION CONTAINS A FIBROS, POROS STRUCTURE AND PROCEDURES FOR THE PRODUCTION OF SUCH A COMPOSITION

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185332B (en) * 1961-03-01 1965-01-14 Ethicon Inc Surgical prosthesis
DE1494939B2 (en) * 1963-06-11 1972-03-02 Buddecke, Eckhart, Prof Dr , 4400 Munster Implantation material for prostheses for the replacement of arteries and other pathways and hollow organs containing body juices and processes for the production thereof
DE1491218B2 (en) * 1963-06-15 1972-06-08 Spofa Sdruzheni Podniku Pro Zdravotnickou Vyrobu, Prag Blood vessel prosthesis and method of making the same
DE1566319B1 (en) * 1966-10-19 1970-10-15 Ethicon Inc Implant
DE1902700A1 (en) * 1969-01-17 1970-08-20 Carlton Sports Company Ltd Artificial bones and joints for the human - body
DE2017330A1 (en) * 1970-04-10 1971-12-09 BIO-CAL Instrument GmbH, 8032 Gräfelfing Blood vessel connector - for artificial kidneys or lungs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zeitschrift MOT 4/76, S.109 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204700A1 (en) * 1981-02-12 1982-09-02 Mitsubishi Chemical Industries, Ltd., Tokyo ARTIFICIAL PROSTHESIC MATERIAL ON A CARBON BASE
US4699141A (en) * 1986-01-16 1987-10-13 Rhode Island Hospital Neovascularization
US5770417A (en) * 1986-11-20 1998-06-23 Massachusetts Institute Of Technology Children's Medical Center Corporation Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5759830A (en) * 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5750103A (en) * 1990-10-19 1998-05-12 The New York University Medical Center Method for transplanting cells into the brain and therapeutic uses therefor
US6060048A (en) * 1990-10-19 2000-05-09 New York University Method for transplanting cells into the brain and therapeutic uses therefor
US6264943B1 (en) 1990-10-19 2001-07-24 New York University Method for transplanting cells into the brain and therapeutic uses therefor
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US7914579B2 (en) 1995-05-01 2011-03-29 Children's Medical Center Corporation Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6348069B1 (en) 1995-05-19 2002-02-19 Children's Medical Center Corporation Engineering of strong, pliable tissues
USRE42479E1 (en) 1995-05-19 2011-06-21 Children's Medical Center Corporation Engineering of strong, pliable tissues
USRE42575E1 (en) 1995-05-19 2011-07-26 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions

Also Published As

Publication number Publication date
BR7900377A (en) 1979-08-14
JPS54119798A (en) 1979-09-17
FR2415456A1 (en) 1979-08-24
CA1118155A (en) 1982-02-16
GB2014475B (en) 1982-04-21
GB2014475A (en) 1979-08-30

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Legal Events

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8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: AMERICAN HOSPITAL SUPPLY CORP., EVANSTON, ILL., US

8128 New person/name/address of the agent

Representative=s name: EITLE, W., DIPL.-ING. HOFFMANN, K., DIPL.-ING. DR.

8125 Change of the main classification

Ipc: A61F 2/02

8130 Withdrawal