DE2735754A1 - COMPOSITION OF SUBSTANCES FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES - Google Patents

COMPOSITION OF SUBSTANCES FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES

Info

Publication number
DE2735754A1
DE2735754A1 DE19772735754 DE2735754A DE2735754A1 DE 2735754 A1 DE2735754 A1 DE 2735754A1 DE 19772735754 DE19772735754 DE 19772735754 DE 2735754 A DE2735754 A DE 2735754A DE 2735754 A1 DE2735754 A1 DE 2735754A1
Authority
DE
Germany
Prior art keywords
substance
glass
carrier
composition according
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772735754
Other languages
German (de)
Inventor
Cyril Francis Drake
Derek Geoffrey Layton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Standard Electric Corp
Original Assignee
International Standard Electric Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Standard Electric Corp filed Critical International Standard Electric Corp
Publication of DE2735754A1 publication Critical patent/DE2735754A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Description

27'JbVb/,27'JbVb /,

C.D.Drake 53-1C.D.Drake 53-1

Stoffzusammensetzung für die gesteuerte Freisetzung biologisch aktiver Stoffe.Composition of substances for the controlled release of biologically active substances.

Die Erfindung betrifft eine Stoffzusammensetzung für die gesteuerte Freisetzung biologisch aktiver Stoffe in einem flüssigen Medium.The invention relates to a composition of matter for controlled release of biologically active substances in a liquid medium.

Der Erfindung liegt die Aufgabe zugrunde, eine Stoffzusammensetzung anzugeben, welche in der Lage ist, in gesteuerter Weise einen biologisch aktiven Stoff in einem flüssigen Medium freizusetzen, insbesondere einen Stoff, der dosierte Mengen eines Wirkstoffes oder eines Heilmittels in den Blutkreislauf eines Tieres abgibt.The invention is based on the object of a composition of matter indicate which is able to contain a biologically active substance in a controlled manner to release a liquid medium, in particular a substance, the metered amounts of an active ingredient or a Releases a remedy into an animal's bloodstream.

Diese Aufgabe ist erfindungsgemäß gelöst durch einenAccording to the invention, this object is achieved by a

organischen Trägerstoff, an den der aktive Stoff physikalisch oder chemisch gebunden ist, und ein Glas, das mit dem Trägerstoff in Kontakt steht und ein wasserlösliches Metallion enthält, das - wenn es aus dem Glas herausgelöst wird - mit dem aktiven Stoff in der Weise reagiert, daß der aktive Stoff vom Trägerstoff freigesetzt wird und in Lösung geht.organic carrier to which the active substance is physically or is chemically bonded, and a glass that is in contact with the carrier and a water-soluble Contains metal ion which - when it is leached out of the glass - reacts with the active substance in such a way that the active substance is released from the carrier and goes into solution.

Ein Ausführungsbeispiel der Erfindung ist nachstehend anhand der Figur beschrieben, welche schematisch den Querschnitt eines Glasteilchens zeigt, das von einemAn embodiment of the invention is described below with reference to the figure, which schematically shows the Shows a cross-section of a glass particle taken by a

809808/0721809808/0721

-1--1-

273575A273575A

C.D.Drake 53-1C.D.Drake 53-1

den biologisch aktiven Stoff enthaltenden Häutchen umhüllt 1st.the membrane containing the biologically active substance is enveloped 1st.

In der Figur 1st das ein anorganisches Ion In wasserlöslicher Form enthaltende Glasteilchen 11 mit einem Häutchen 12 aus einem plastischen oder natürlichen Harzwerkstoff, wie Zellulose oder Zellulosederivat, umhüllt. Der Harzwerkstoff trägt einen biologisch aktiven Stoff, wie ein Antibiotikum, ein Hormon oder ein Wirkstoff, der physikalisch oder chemisch an den Harzwerkstoff gebunden ist. Das anorganische Ion und der aktive Stoff sind so gewählt, daß - wenn die Zusammensetzung in eine wässrige Umgebung, wie den Blutkreislauf eines Tieres, gebracht wird - sich das Ion aus dem Glas löst und mit dem aktiven Stoff im Harz reagiert, so daß der aktive Stoff in Lösung geht.In the figure, this is an inorganic ion more soluble in water Form containing glass particles 11 with a Skin 12 made of a plastic or natural resin material, such as cellulose or cellulose derivative, enveloped. The resin material carries a biologically active substance, such as an antibiotic, a hormone or an active ingredient, which is physically or chemically bound to the resin material. The inorganic ion and the active substance are chosen so that - when the composition is in an aqueous environment, such as the bloodstream of an animal - the ion is released from the glass and reacts with the active substance in the resin, so that the active substance goes into solution.

Die umhüllten Teilchen können in Pillenform gepreßt werden, so daß subkutane Einpflanzungen vorgenommen werden können, wodurch für einen längeren Zeitraum eine ständige Zufuhr des aktiven Stoffes in den Blutkreislauf eines Tieres erfolgt.The coated particles can be compressed into pill form so that subcutaneous implantations are made can be, whereby a constant supply of the active substance into the bloodstream for a longer period of time of an animal.

Das Glas kann auf der Basis von Phosphor oder Boroxid aufgebaut sein. Die Zusammensetzung kann in Form von beschichteten Fäden aufbereitet sein; es können aber auch separate Glas- und Harzteilchen verwendet werden.The glass can be based on phosphorus or boron oxide. The composition can be in the form of coated threads be processed; however, separate glass and resin particles can also be used.

Für eine andere Anwendung kann das Harz auch ein bestimmtes Unkrautvertilgungsmittel und/oder ein Schädlingsbekämpfungsmittel für die Verwendung im Erdboden enthalten.For another application, the resin can also contain a specific herbicide and / or pesticide for use in the ground included.

809808/0721809808/0721

Claims (5)

Patentanwalt 2 7 3 5 '-' S Dipl.-Phys.Leo Thul Kurze Str. 8 7 Stuttgart 30 C.D.Drake-D.Layton 53-1 INTERNATIONAL STANDARD ELECTRIC CORPORATION, NEW YORK AnsprüchePatent Attorney 2 7 3 5 '-' S Dipl.-Phys. Leo Thul Kurz Str. 8 7 Stuttgart 30 C.D.Drake-D.Layton 53-1 INTERNATIONAL STANDARD ELECTRIC CORPORATION, NEW YORK Claims 1. StoffZusammensetzung für die gesteuerte Freisetzung biologisch aktiver Stoffe in einem flüssigen Medium, gekennzeichnet durch einen organischen Trägerstoff, an den der aktive Stoff physikalisch oder chemisch gebunden ist, und ein Glas, das mit dem Trägerstoff in Kontakt steht und ein wasserlösliches Metallion enthält, das - wenn es aus dem Glas herausgelöst wird - mit dem aktiven Stoff in der Weise reagiert, daß der aktive Stoff vom Trägerstoff freigesetzt wird und in Lösung geht.1. Substance composition for the controlled release biologically active substances in a liquid medium, characterized by an organic carrier that the active substance is physically or chemically bound, and a glass that is in contact with the carrier substance and contains a water-soluble metal ion that - when it is released from the glass - with the active substance reacts in such a way that the active substance is released from the carrier and in solution goes. 2. StoffZusammensetzung nach Anspruch 1, dadurch gekennzeichnet, daß das Glas auf der Grundlage von Phosphoroder Boroxid aufgebaut ist.2. Substance composition according to claim 1, characterized in that that the glass is based on phosphorus or boron oxide. 3. StoffZusammensetzung nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, daß der Trägerstoff eine Zellulose oder ein Zellulosederivat ist.3. Substance composition according to one of claims 1 or 2, characterized in that the carrier is a cellulose or a cellulose derivative. Bö/SchBo / Sch 28.7.1977 809808/07217/28/1977 809808/0721 2 r' '; S'" S /.2 r ' '; S '"S /. C.D.Drake 53-1C.D.Drake 53-1 4. StoffZusammensetzung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß das Glas in Fadenform vorliegt und mit dem Trägerstoff Überzogen ist.4. Substance composition according to one of claims 1 to 3, characterized in that the glass is in the form of threads and is coated with the carrier material. 5. StoffZusammensetzung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß sie Tablettenform besitzt.5. Substance composition according to one of claims 1 to 3, characterized in that it is in tablet form. 809808/0721809808/0721 ORIGINAL INSPECTEDORIGINAL INSPECTED
DE19772735754 1976-08-19 1977-08-09 COMPOSITION OF SUBSTANCES FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES Withdrawn DE2735754A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3458176A GB1542414A (en) 1976-08-19 1976-08-19 Arrangements for the controlled release of biologically active materials

Publications (1)

Publication Number Publication Date
DE2735754A1 true DE2735754A1 (en) 1978-02-23

Family

ID=10367407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772735754 Withdrawn DE2735754A1 (en) 1976-08-19 1977-08-09 COMPOSITION OF SUBSTANCES FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES

Country Status (3)

Country Link
JP (1) JPS5350317A (en)
DE (1) DE2735754A1 (en)
GB (1) GB1542414A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0410664A1 (en) * 1989-07-26 1991-01-30 Borden (Uk) Limited Composite bolus and its use
US5849331A (en) * 1994-07-27 1998-12-15 The Trustees Of The University Of Pennsylvania Incorporation of biological molecules into bioactive glasses

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE455836B (en) * 1985-10-11 1988-08-15 Haessle Ab PREPARATION WITH CONTROLLED RELEASE CONTAINING A SALT OF METOPROLOL AND METHOD FOR PREPARING THIS PREPARATION
SE450087B (en) * 1985-10-11 1987-06-09 Haessle Ab GRAINS WITH CONTROLLED RELEASE OF PHARMACIFICALLY ACTIVE SUBSTANCES APPLIED SIGNED ON A COMPACT INSULABLE NUCLEAR MATERIAL
SE8703881D0 (en) * 1987-10-08 1987-10-08 Haessle Ab NEW PHARMACEUTICAL PREPARATION
CN103550880A (en) * 2013-10-28 2014-02-05 王云荣 Backpack forest fire treatment device

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0410664A1 (en) * 1989-07-26 1991-01-30 Borden (Uk) Limited Composite bolus and its use
US5849331A (en) * 1994-07-27 1998-12-15 The Trustees Of The University Of Pennsylvania Incorporation of biological molecules into bioactive glasses
US5874109A (en) * 1994-07-27 1999-02-23 The Trustees Of The University Of Pennsylvania Incorporation of biological molecules into bioactive glasses

Also Published As

Publication number Publication date
GB1542414A (en) 1979-03-21
JPS5350317A (en) 1978-05-08

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