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Publication numberCN1780652 A
Publication typeApplication
Application numberCN 200480011780
PCT numberPCT/EP2004/002115
Publication date31 May 2006
Filing date3 Mar 2004
Priority date3 Mar 2003
Also published asCA2517741A1, CA2517741C, CA2518013A1, CA2518013C, CN100443128C, DE202004021390U1, DE202004021469U1, DE202004021470U1, DE602004013558D1, DE602004016298D1, DE602004019351D1, DE602004031309D1, EP1603610A1, EP1603610B1, EP1603611A1, EP1603611B1, EP1920794A1, EP1920794B1, EP1974761A2, EP1974761A3, EP1974761B1, EP2011531A2, EP2011531A3, EP2011531B1, EP2263721A2, EP2263721A3, EP2263721B1, EP2263722A2, EP2263722A3, EP2263722B1, EP2263723A2, EP2263723A3, EP2263723B1, EP2263724A2, EP2263724A3, EP2263724B1, EP2266648A2, EP2266648A3, EP2266648B1, EP2281592A2, EP2281592A3, EP2281592B1, EP2283886A2, EP2283886A3, EP2283886B1, US7850662, US7918833, US7935088, US8512297, US8556864, US8603044, US8679069, US8992486, US9011391, US9028454, US9233211, US9408979, US9526844, US9533105, US9561331, US9604008, US9604009, US9610409, US9623189, US9623190, US9775954, US20040267208, US20050033244, US20060264839, US20070093761, US20090198193, US20110152784, US20110178474, US20110276009, US20120089100, US20130267906, US20130274680, US20130304024, US20140316344, US20140316345, US20140316346, US20140316347, US20140316348, US20140316349, US20140316374, US20150174334, US20160074590, US20160256633, US20160296708, US20160303329, WO2004078239A1, WO2004078241A1
Publication number200480011780.4, CN 1780652 A, CN 1780652A, CN 200480011780, CN-A-1780652, CN1780652 A, CN1780652A, CN200480011780, CN200480011780.4, PCT/2004/2115, PCT/EP/2004/002115, PCT/EP/2004/02115, PCT/EP/4/002115, PCT/EP/4/02115, PCT/EP2004/002115, PCT/EP2004/02115, PCT/EP2004002115, PCT/EP200402115, PCT/EP4/002115, PCT/EP4/02115, PCT/EP4002115, PCT/EP402115
InventorsRF维齐, R珀金斯, DA普伦普特里
ApplicantDca设计国际有限公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Drive mechanish for drug delivery devices.
CN 1780652 A
Abstract  translated from Chinese
一种用于给药装置的驱动机构,包括:具有螺旋螺纹优选地为内部螺旋螺纹的壳体;具有与所述壳体的螺旋螺纹相接合的螺旋螺纹的剂量标度套管(70);可释放地连接到所述剂量标度套管(70)的驱动套管(30);以及位于该剂量标度套管(70)和驱动套管(30)之间的离合器装置(60)。 A delivery device for driving the mechanism, comprising: a helical thread preferably having internal helical thread of the housing; the housing having a helical thread engaged with the helical thread of the dose dial sleeve (70); releasably connected to said dose dial sleeve (70) of the drive sleeve (30); and clutch means located in the dose dial sleeve (70) and the drive sleeve (30) between (60). 当该剂量标度套管(70)和驱动套管(30)联接时,允许该两者相对于该壳体旋转。 When the dose dial sleeve (70) and the drive sleeve (30) is coupled, allowing the rotation of both relative to the housing. 当该剂量标度套管(70)和驱动套管(30)断开联接时,允许该剂量标度套管(70)相对于该壳体旋转,但不允许该驱动套管(30)相对于该壳体旋转,其中允许该驱动套管(30)进行轴向运动以便沿纵向方向将力传递到给药装置的近端。 When the dose dial sleeve (70) and the drive sleeve (30) to disconnect, allowing the dose dial sleeve (70) relative to the rotating housing, but does not allow the drive sleeve (30) relative to rotation in the housing, wherein allowing the drive sleeve (30) so that axial movement of the force transmission in the longitudinal direction to the proximal end of the delivery device.
Claims(13)  translated from Chinese
1.一种用于给药装置的驱动机构,包括:具有螺旋螺纹且优选地为内部螺旋螺纹的壳体;具有与所述壳体的螺旋螺纹相接合的螺旋螺纹的剂量标度套管;可释放地连接到所述剂量标度套管的驱动套管;以及位于该剂量标度套管和驱动套管之间的离合器装置;其特征在于,a)当该剂量标度套管和驱动套管联接时,允许该剂量标度套管和驱动套管两者相对于该壳体旋转;以及b)当该剂量标度套管和驱动套管断开联接时,允许该剂量标度套管相对于该壳体旋转,但不允许该驱动套管相对于该壳体旋转,其中允许该驱动套管进行轴向运动以便沿纵向方向将力传递到给药装置的近端。 1. A mechanism for driving a delivery device, comprising: a helical thread and preferably having an internal helical thread of the housing; dose dial of the housing having a helical thread engaged with the helical thread of the sleeve; releasably connected to said dose dial sleeve of the drive sleeve; and a clutch means and the dose dial sleeve between the drive sleeve; characterized in that, a) when the dose dial sleeve and the drive When the coupling sleeve, allowing the dose dial sleeve and the drive sleeve with respect to the housing between rotating; and b) when the dose dial sleeve and the drive sleeve to disconnect allows the dose dial sleeve rotating the tube relative to the housing, but does not allow the drive sleeve with respect to the rotation of the housing, wherein the drive sleeve allows axial movement so as to transmit force in the longitudinal direction to the proximal end of the delivery device.
2.根据权利要求1的驱动机构,其特征在于,该驱动机构包括活塞杆,该活塞杆适于穿过该壳体操作,并沿所述纵向方向将所述力传递到该给药装置的近端。 2. The drive mechanism according to claim 1, characterized in that the drive mechanism comprises a piston rod, the piston rod is adapted to operate through the housing and along the longitudinal direction of the force transmitted to the delivery device Proximal.
3.根据权利要求1或2的驱动机构,其特征在于,所述剂量标度套管还包括螺旋螺纹,该螺纹的导程与所述驱动套管的螺旋螺纹的导程相同。 The drive mechanism as claimed in claim 1 or 2, characterized in that said dose dial sleeve further comprises a helical thread, the lead of the thread of the drive sleeve with the same lead of the helical thread.
4.根据权利要求1或2的驱动机构,其特征在于,所述活塞杆设计成附装有一齿轮,该齿轮设计成与该驱动套管的螺纹以及一齿条的齿相啮合,其中所述齿条固定在该壳体上。 4. The drive mechanism as claimed in claim 1 or 2, wherein said piston rod is designed to be attached is provided with a gear which is designed to be engaged with the drive sleeve thread and a rack of teeth, wherein said rack mounted on the housing.
5.一种用于给药装置的组件,包含权利要求1-4中任一项所述的驱动机构。 5. An assembly for administering apparatus, comprising a driving mechanism according to claim any one of claims 1-4.
6.一种给药装置,包含权利要求1-4中任一项所述的驱动机构或权利要求5所述的组件。 A delivery device, comprising the drive mechanism as claimed in any one of claims 1-4 or according to claim 5, wherein the claim component.
7.根据权利要求6的给药装置,其特征在于,该给药装置是笔型装置。 7. The administering apparatus according to claim 6, characterized in that the administration device is a pen-type device.
8.根据权利要求6或7的给药装置,其特征在于,该给药装置是注射器类型的装置。 8. The administering device according to claim 6 or claim 7, characterized in that the administration means is a syringe type device.
9.根据权利要求6-8中任一项的给药装置,其特征在于,该给药装置包含针头。 9. The administering apparatus according to any one of claims 6-8, characterized in that the administering device comprises a needle.
10.根据权利要求6-8中任一项的给药装置,其特征在于,该给药装置是不带针头的装置。 10. The administering apparatus according to any one of claims 6-8, characterized in that the dosing device is without needle device.
11.根据权利要求6-10中任一项所述的给药装置用于分配药品的应用。 11. The administering apparatus according to any one of 6-10 claims for use according to the distribution of drugs.
12.根据权利要求11的给药装置的应用,其用于分配包含选自胰岛素、生长激素、低分子量肝素以及它们的类似物和衍生物的活性化合物的药物配方。 12. The application of the medication administering device according to claim 11, which comprises for dispensing selected from insulin, growth hormone drug formulation, low molecular weight heparins, and their analogues and derivatives of the active compound.
13.一种制造或组装给药装置的方法,该方法包括提供权利要求1-4中任一项所述的驱动机构或权利要求5所述的组件的步骤。 13. A method of manufacturing or assembling a medication administering device, the method comprising providing a drive mechanism or the claims in any one of claims 1 to 4 wherein the step of assembly of claim 5.
Description  translated from Chinese
用于给药装置的驱动机构 Means for driving the dosing device

技术领域 FIELD

本发明涉及适用于给药装置(药品输送装置)尤其是笔型注射器的驱动机构,该驱动机构具有剂量设定装置,从而使得可从多次剂量的药筒进行药品的给药。 The present invention relates to a device suitable for administration (drug delivery system) in particular pen-type injector drive mechanism, the drive mechanism having a dose setting device, so that the drug can be administered from multi-dose cartridge. 具体地,本发明涉及其中用户可设定剂量的给药装置。 In particular, the present invention relates to where the user can set the dose delivery device.

背景技术 BACKGROUND

这种给药装置应用于由未受到正规医学培训的人员即患者进行定时注射的场合。 Such administration device is applied by a person not being formal medical training, i.e., patients injection timing occasions. 这在患有糖尿病的患者中越来越普遍,自我治疗使得这种人员可对他们的糖尿病进行有效的用药。 This is more common in patients with diabetes, self-treatment makes this staff can effectively manage their diabetes medication.

这些情况为这种给药装置提出了许多要求。 These conditions for such administration means a number of requirements. 这种装置的结构必须坚固,并且就部件的操作以及使用者对其操作和所需剂量药品的输送的理解来说,要易于使用。 The structure of such a device must be strong, and then operate and user components needed to understand its operation and delivery of the drug dose, it should be easy to use. 剂量设定必须容易且明确。 Dose setting must be easy and clear. 在使用者患有糖尿病的情况下,许多使用者体质弱且还可能视力减退,这就要求该驱动机构具有较低的分配力,且剂量设定显示器易于读取。 In the case of a user with diabetes, many users may also be weak constitution and vision loss, which requires that the drive mechanism has a lower allocation of power, and the dose setting display is easy to read. 在该装置是一次性的而不是可重复使用的情况下,该装置的制造应便宜,且易于处理(优选地适于回收)。 And the means is not the case under the disposable, reusable, the device should be inexpensive manufacture and easy to dispose of (preferably suitable for recycling). 为了满足这些要求,组装该装置所需的部件的数量以及制造该装置的材料种类的数量需要保持最小。 To meet these requirements, the number of the number and the type of material for manufacturing the device of the apparatus required for assembling the components need to be kept to a minimum.

由使用者操作的给药装置在医药领域内是公知的。 Administering device operated by a user in the field of medicine are known.

US5304152中公开了一种分配装置,其体部长度与活塞长度的比率是大约1∶1以便可分配较大的剂量。 US5304152 discloses a dispensing apparatus, the ratio of Length of the body and its length is about 1:1 piston so as to be assigned a larger dose. 尽管此种装置比现有技术有了很大改进,但是在既不分配设定量的流体又不拆开药筒的条件下容易地对过剂量的设定进行改正的问题仍没有解决。 Although this means a great improvement over the prior art, but in neither assigned set amount of fluid conditions without disassembly of the cartridge easily over the setting of the dose correction is not solved the problem.

WO9938554A2提出一种从药筒中分配设定剂量的药品的注射器,其中公开了一种包括单向联接件(即棘轮)的驱动机构,该驱动机构允许改正设定的过多剂量而不需要分配该设定量的流体或需要拆开该药筒。 WO9938554A2 proposes a set dose of drug distribution from the cartridge of the syringe, which is disclosed comprising a unidirectional coupling (i.e., a ratchet) drive mechanism, the drive mechanism allows the dosage to correct excessive allocation of the set without the need set amount of fluid or the need to disassemble the drug cartridge.

令人惊讶的是,已发现不具有单向联接件的根据本发明的驱动机构为驱动机构提供了一种有价值的技术方案,其中致动该机构所需的力减小。 Surprisingly it has been found not having a unidirectional coupling provides a valuable technical solution for the drive mechanism according to the driving mechanism of the present invention, wherein the actuating force is required for this mechanism is reduced. 这可通过引入本发明所限定的离合器装置来实现。 This is achieved by the introduction of a clutch means as defined in the present invention is achieved. 根据本发明的驱动机构还具有直观和容易使用以改正设定的剂量的优点。 Also has an intuitive and easy to use to set the correct dose of the advantages according to the driving mechanism of the present invention.

发明内容 SUMMARY

根据本发明的第一个方面,提供一种用于给药装置的驱动机构,包括:具有螺旋螺纹的壳体;具有与所述壳体的螺旋螺纹相接合的螺旋螺纹的剂量标度套管;可释放地连接到所述剂量标度套管的驱动套管;以及位于该剂量标度套管和驱动套管之间的离合器装置;其特征在于,a)当该剂量标度套管和驱动套管联接时,允许该剂量标度套管和驱动套管相对于该壳体旋转;以及b)当该剂量标度套管和驱动套管断开联接时,允许该剂量标度套管相对于该壳体旋转,而不允许该驱动套管相对于该壳体旋转,其中允许该驱动套管进行轴向运动,从而沿纵向方向向该给药装置的近端传递力。 According to a first aspect of the present invention, there is provided a drive mechanism for a delivery device, comprising: a housing having a helical thread; dose dial having a helical thread engaged with the housing of the helical thread sleeve ; releasably connected to said dose dial sleeve of the drive sleeve; and a clutch means and the dose dial sleeve between the drive sleeve; characterized in that, a) when the dose dial sleeve and When drive sleeve coupling, allowing the dose dial sleeve and the drive sleeve with respect to the rotating housing; and b) when the dose dial sleeve and the drive sleeve to disconnect allows the dose dial sleeve with respect to the rotation of the housing, but does not allow the drive sleeve with respect to the rotation of the housing, wherein the drive sleeve allowing axial movement, thus in the longitudinal direction to the proximal end of the delivery device to transmit force.

在本发明的驱动机构的一优选实施例中,所述驱动机构还包括一活塞杆,该活塞杆适于穿过该壳体操作,并沿所述纵向方向将所述力传递给该给药装置的近端。 In the driving mechanism of the present invention a preferred embodiment, the drive mechanism further comprises a piston rod adapted to operate through the housing and along the longitudinal direction of the force will be transmitted to the administration proximal end of the device.

在本发明的驱动机构的另一优选实施例中,所述剂量标度套管还包括螺旋螺纹,该螺纹的导程与所述驱动套管的螺纹的导程相同。 In another preferred embodiment of the drive mechanism of the present invention, the dose dial sleeve further comprises a helical thread, the lead of the thread of the drive sleeve with the same thread leads.

在本发明的一更具体的实施例中,该驱动机构还包括一螺母,其可相对于该驱动套管旋转并可轴向移动,但是不能相对于该壳体旋转。 In a more specific embodiment of the invention, the drive mechanism further comprises a nut, which may be rotating with respect to the drive sleeve and axially movable, but not rotation relative to the housing.

根据本发明的术语“给药装置”是指设计成用于分配选定剂量的药品(优选地是多次选定剂量)例如胰岛素、生长激素、低分子量肝素以及它们的类似物和/或衍生物等的单次剂量或多次剂量的、一次性的或可重复使用的装置。 According to the present invention, the term "administration device" refers designed for dispensing the selected drug dose (preferably multiple selected doses) such as insulin, growth hormone, low molecular weight heparins, and their analogues and / or derivatives the like of single dose or multiple doses, disposable or reusable means. 所述装置可以是任何类型的,例如小型或笔型。 The device may be of any type, such as small or pen-type. 可通过机械(任选地,手动)或电力驱动机构或储能驱动机构例如弹簧等来实现剂量输送。 By mechanical (optionally manual) or electrical drive mechanism or stored energy drive mechanism, such as a spring, dose delivery. 可通过手动机构或电子机构来实现剂量选择。 Through a manual mechanism or electronic mechanism dose selection. 另外,所述装置可包括设计成用于监控生理特性例如血糖等级等的元件。 Further, the device may be designed to include an element such as blood glucose levels, etc. for monitoring physiological characteristics. 而且,所述装置可包括针头或者没有针头。 Moreover, the device may comprise a needle or no needle. 特别地,术语“给药装置”是指具有机械和手动剂量输送和剂量选择机构的一次性的、多次剂量的笔型装置,该装置设计成可由没有受过正规医学训练的人例如患者定时使用。 In particular, the term "administration device" refers to disposable, multi-dose pen-type device having mechanical and manual dose delivery and dose selection mechanisms, which means are designed to be no formal medical training such as patients who use the timing . 优选地,给药装置是注射器型的。 Preferably, the administering device is a syringe-type.

根据本发明的术语“壳体”优选地是指具有螺旋螺纹的任何外部壳体(“主壳体”、“体部”、“壳”)或内部壳体(“插入件”、“内体部”)。 According to the present invention, the term "housing" shall preferably mean any exterior housing having a helical thread ("main housing", "body", "shell") or interior housing ("insert", "inner body portion "). 该壳体设计成使得能够安全、正确和舒适地操纵该给药装置或其任何机构。 The housing is designed to enable the safe, correct, and comfortable handling of the drug delivery devices or any agency thereof. 通常,该壳体设计成通过对暴露于污染物例如液体、灰尘、污垢等进行限制来容纳、固定、保护、引导和/或接合该给药装置的任何内部元件(例如驱动机构、药筒、活塞、活塞杆)。 Typically, the housing is designed by exposure to contaminants such as liquid, dust, dirt, etc. to be limiting to house, fix, protect, guide, and any internal elements (e.g., the drive mechanism, cartridge of the administering device and / or bonding, piston, piston rod). 通常,该壳体可以是管形或非管形的一体的或多部件的元件。 Typically, the housing may be of tubular or non-tubular or multi-part integral member. 通常,该外部壳体用于容纳药筒,可从该药筒分配多种剂量的药品。 Typically, the outer housing for accommodating the cartridge, dispensing multiple doses of drug from the drug cartridge.

在本发明的一更具体的实施例中,该外部壳体具有多个最大剂量止动件,该止动件适于被设置在该剂量标度套管上的径向止动件紧靠于其上。 In a more specific embodiment of the invention, the outer housing having a plurality of maximum dose stops, the stopper member is adapted to radial stop provided on the dose dial sleeve abuts in thereon. 优选地,至少一个该最大剂量止动件包括位于螺旋螺纹和设置在壳体的第二端处的花键装置之间的径向止动件。 Preferably, at least one of the maximum dose stops comprises a helical thread and is located between the spline means provided at the second end of the housing of the movable member angular.

可选择地,至少一个该最大剂量止动件包括设置在该壳体的第二端处的抬高的窗口部分的一部分。 Alternatively, at least one of the maximum dose stops comprises a raised window portion provided at a second end portion of the housing.

根据本发明的术语“接合的”尤其是指该驱动机构/给药装置的两个或更多元件的联锁,例如花键、螺纹或啮合的齿的连接,优选地是元件的螺旋螺纹的联锁(“螺纹接合”)。 According to the present invention, the term "joined" refers particularly to the interlocking of two or more elements of the drive mechanism / drug administration device, e.g., a spline, thread, or meshed teeth connection, preferably a helical thread element Interlock ("thread engagement").

根据本发明的术语“螺旋螺纹”优选地是指位于给药装置的元件的内部和/或外部表面上的全螺纹或部分螺纹,例如圆柱形螺旋肋部/凹槽,其横截面基本为三角形或方形或圆形,并设计成允许在元件之间进行连续的自由旋转和/或轴向运动。 According to "screw thread" of the present invention, the term preferably refers to administering device elements located inside and / or all or part of the thread on the threaded outer surface, e.g., a cylindrical spiral rib / groove, is substantially triangular in cross-section or square or round, and is designed to allow continuous between the elements free rotation and / or axial movement. 任选地,螺纹还可设计成阻止特定的元件沿一个方向发生旋转运动或轴向运动。 Optionally, the thread can be designed to prevent rotational movement of a particular component or axial movement in one direction occur.

根据本发明的术语“剂量标度套管”是指其横截面基本为圆形的基本为管形的元件,包括:a)内部和外部螺纹,或b)内部螺纹,或c)外部螺纹,优选地,根据本发明的剂量标度套管包括螺旋螺纹,该螺纹的导程接近且优选地等于驱动套管的螺旋螺纹的导程。 According to the present invention, the term "dose dial sleeve" refers to a substantially circular cross-section of a substantially tubular member, comprising: a) internal and external thread, or b) an internal thread, or c) an external thread, Preferably, the dose dial sleeve according to the present invention comprises a helical thread, the lead screw is accessible and is preferably equal to the helical thread of the drive sleeve lead. 在另一个优选实施例中,该剂量标度套管设计成用于指示选定剂量的可分配的药品。 In another preferred embodiment, the dose dial sleeve is designed to indicate a selected dose of the drug can be allocated. 这可通过使用例如印制在剂量标度套管的外表面上的标记、符号、数字等或测距器或类似物来实现。 This can be accomplished using, for example printed on the dose dial sleeve of the outer surface of the marker, symbols, numbers, etc. or a range finder or the like to achieve.

在本发明的一更具体的实施例中,剂量标度套管具有多个径向延伸的构件,该构件适于紧靠设置在该壳体的第二端的对应的多个径向止动件。 In a more specific embodiment of the invention, the dose dial sleeve having a plurality of radially extending member, the member is adapted to abut a corresponding plurality of radially disposed at a second end of the housing of the stopper .

根据本发明的术语“导程”优选地是指螺母在旋转一整圈时前进的轴向距离;优选地,“导程”是指驱动机构的具有螺旋螺纹的元件,即剂量标度套管、驱动套管、活塞杆等在一次旋转期间行进的轴向距离。 According to the present invention, the term "lead" shall preferably mean the axial distance a nut in one full rotation when advancing; preferably "lead" means a member having a helical thread of the drive mechanism, i.e. dose dial sleeve During traveling, drive sleeve, piston rod, etc. in a rotating axial distance. 因此,导程与相关元件的螺纹的螺距有关。 Thus, the lead pitch of the threads associated with the relevant element.

根据本发明的术语“螺距”优选地是指平行于螺旋螺纹的轴线测量出的螺旋螺纹上的连续轮廓之间的距离。 According to the present invention, the term "pitch" shall preferably mean the distance between consecutive contours parallel to the axis of the helical thread of the helical thread on the measured between.

根据本发明的术语“驱动套管”是指其横截面基本为圆形的任何基本为管形的元件,该元件可释放地连接到该剂量标度套管上。 According to the present invention, the term "drive sleeve" refers to the cross-section of substantially any substantially circular tubular element, the element is releasably connected to the dose dial sleeve. 在一优选实施例中,该驱动套管还与活塞杆相接合。 In a preferred embodiment, the drive sleeve is further engaged with the piston rod.

在本发明的一更具体的实施例中,该驱动套管在第一端具有第一和第二凸缘,并在该第一和第二凸缘之间具有中间螺旋螺纹,从而使一螺母设置在该第一和第二凸缘之间并通过花键装置连接到该壳体上。 In a more specific embodiment of the invention, the drive sleeve having a first end at a first and a second flange, and between the first and second flanges with an intermediate helical thread, so that a nut disposed between the first and second flanges and connected to the housing by spline means. 任选地,可在螺母的第二表面上设置第一径向止动件,并在第二凸缘的第一表面上设置第二径向止动件。 Optionally, a first radial stop member disposed on the second surface of the nut and a second radial stop member disposed on the first surface of the second flange.

根据本发明的术语“可释放地连接”优选地是指本发明的机构或装置的两个元件例如通过离合器可逆地相互连接,这使得可以相接合和脱离接合。 According to the present invention, the term "releasably coupled" preferably refers to two elements of the present invention, mechanism or means, for example, reversibly connected to each other via a clutch, which makes it possible to engage and disengage engagement.

根据本发明的术语“活塞杆”是指适于穿过该壳体/在该壳体内操作的元件,其设计成用于穿过该给药装置/在该给药装置内传递轴向运动,优选地从驱动套管传递到该活塞,以便排出/分配可注射的药品。 According to the present invention, the term "rod" means that the housing / operating element in the housing is adapted to pass through, which is designed to be used through the administering device / transfer axial movement within the delivery device, preferably transmitted from the drive sleeve to the piston, so that the discharge / dispensing an injectable drug. 所述活塞杆可以是柔性的,也可以不是柔性的。 The piston rod may be flexible, or may not be flexible. 它可以是简单的杆、导向螺杆、齿条齿轮系统、蜗轮传动系统或类似物。 It may be a simple rod, a lead screw, rack and pinion system, a worm drive system or the like. “活塞杆”还指其横截面为圆形或非圆形的元件。 "Piston rod" also means a circular or non-circular cross-sectional elements. 该活塞杆可由本领域内的技术人员已知的任何合适的材料制成。 The piston rod may be known to those skilled in the art of any suitable material.

在一优选实施例中,活塞杆包括至少一个、多个(优选地两个)外部和/或内部螺旋螺纹。 In a preferred embodiment, the piston rod comprises at least one of a plurality (preferably two) external and / or internal helical threads. 在根据本发明的活塞杆的另一优选实施例中,第一螺旋螺纹位于所述活塞杆的第一端,且第二螺旋螺纹位于所述活塞杆的第二端,其中所述螺纹的设置相同或优选地相反。 In accordance with another preferred embodiment of the piston rod of the present invention, a first helical thread is located at a first end of said piston rod, and a second helical thread is located in a second end of said piston rod, wherein the thread is provided Preferably the same or opposite. 在另一优选实施例中,本发明的活塞杆在第一和第二端包括导程相同的螺纹。 In another preferred embodiment, the piston rod of the present invention is the same thread in the first and second end including lead.

在本发明的另一优选实施例中,活塞杆的第一螺旋螺纹的导程大于第二螺旋螺纹的导程。 In another preferred embodiment of the present invention, a first helical thread of the piston rod is greater than the lead of the second helical thread lead. 更优选地,所述第一和第二螺旋螺纹的螺纹导程的比率是1∶1.01到1∶20,甚至更优选地是1∶1.1到1∶10。 More preferably, the first and second helical thread thread turn ratio 1:1.01 to 1:20, even more preferably 1:1.1 to 1:10. 优选地,所述螺纹之一设计成与该驱动套管相接合。 Preferably, one of said threads is designed to engage with the drive sleeve.

可选择地,在本发明的活塞杆的另一优选实施例中,活塞杆设计成任选地通过轴颈轴承附装一齿轮,其中所述齿轮设计成与该驱动套管的螺纹以及一齿条的齿相啮合,其中所述齿条固定在该壳体上。 Alternatively, in another preferred embodiment the piston rod of the present invention, the piston rod is designed to be optionally mounted a gear attached by a journal bearing, wherein said gear is designed to the threads of the drive sleeve and a tooth Article engaged teeth, wherein the rack fixed to the housing.

根据本发明的术语“第一端”是指近端。 According to the present invention, the term "first end" refers to the proximal end. 该装置或该装置的元件的近端是指距离该装置的分配端最近的端部。 The proximal end of the device or element of the apparatus refers to the dispensing end of the device from the nearest end portion.

根据本发明的术语“第二端”是指远端。 According to the present invention, the term "second end" refers to the distal end. 该装置或该装置的元件的远端是指距离该装置的分配端最远的端部。 The distal end of the device or component of the device shall mean the end away from the dispensing end of the device furthest.

根据本发明的术语“离合器装置”是指任何这样的装置:该装置使该剂量标度套管和该驱动套管可释放地连接,并且该装置设计成允许在该剂量标度套管和该驱动套管联接时该剂量标度套管和该驱动套管相对于该壳体旋转,并在两者脱离联接时,允许该剂量标度套管相对于该壳体旋转,但不允许该驱动套管相对于该壳体旋转,并允许该驱动套管轴向运动。 According to the present invention, the term "clutch means" refers to any such apparatus: the apparatus so that the dose dial sleeve and the drive sleeve releasably connected, and the apparatus is designed to allow the dose dial sleeve and the When the drive sleeve is coupled dose dial sleeve and the drive sleeve with respect to the rotation of the housing, and when both decoupled, allowing the dose dial sleeve with respect to the rotation of the housing, but does not allow the driver rotation of the sleeve relative to the housing, and allow the axial movement of the drive sleeve. 优选地,该离合器装置将驱动套管可释放地连接到壳体。 Preferably, the clutch means of the drive sleeve releasably connected to the housing. 因此,术语“离合器装置”是指为了可逆地锁定两个元件使其不能(相对)旋转而接合的任何离合器,例如通过使用轴向力以使一组表面齿(锯齿、犬齿、冠齿)或任何其它合适的摩擦面相接合。 Thus, the term "clutch means" means for reversibly locking two elements so that it can not be (relatively) any rotation of the clutch engagement, for example by using an axial force to the surface of a set of teeth (serrations, canine teeth, crown teeth) or any other suitable surface friction engagement.

在本发明的一更具体的实施例中,离合器装置的第二端具有多个适于与剂量标度套管的第二端相接合的犬齿。 In a more specific embodiment of the invention, the second end having a plurality of clutch means and a dose dial sleeve, adapted to a second end of the engaging canines.

在一可选择的实施例中,本发明的离合器装置是锁紧弹簧,其可例如通过剂量标度按钮在松弛的第一位置和变形的第二位置之间操作,在该第一位置该剂量标度套管被锁定成与该驱动套管一起旋转,在该第二位置该剂量标度套管被锁定成与该壳体一起旋转。 In an alternative embodiment, the clutch device of the present invention is a locking spring, which may for example by a dose dial button between a first position and a relaxed position deformed second operation, in the first position of the dose dial sleeve is locked for rotation with the drive sleeve, is locked for rotation with the housing at the second position of the dose dial sleeve.

在本发明的又一实施例中,驱动机构还包括任选地设置在该离合器装置和设置在该壳体上的花键装置之间的响声器装置(clicker means)。 In yet another embodiment of the present invention, the drive mechanism further comprises optionally provided in the sound device (clicker means) between the clutch means and disposed on the housing spline means.

任选地,该响声器装置包括一套管,该套管在第一端具有螺旋形延伸的臂,在该臂的自由端具有一带齿构件,并在第二端具有多个沿圆周定向的锯齿,该锯齿适于接合设置在该离合器装置上的对应的多个沿圆周的锯齿。 Optionally, the sound device includes a sleeve, the sleeve having at a first end of the helically extending arm, at the free end of the arm having a toothed member, and at a second end having a plurality of circumferentially oriented serrated, the serrations adapted to engage clutch means provided on the corresponding plurality of circumferentially saw teeth.

可选择地,该响声器装置包括一套管,该套管在第一端具有至少一个螺旋形延伸的臂和至少一个弹簧件,在该臂的自由端具有一带齿构件,并在第二端具有多个沿圆周定向的锯齿,该锯齿适于接合设置在该离合器装置上的对应的多个沿圆周定向的锯齿。 Alternatively, the sound device includes a sleeve, the sleeve having at a first end of at least one helically extending arm and at least one spring member, a free end of the arm having a toothed member, and at a second end having a plurality of circumferentially directed saw teeth, the saw-tooth adapted to engage clutch means provided on the corresponding plurality of circumferentially directed saw teeth.

在本发明的驱动机构的另一实施例中,该驱动机构具有第一止动装置,该止动装置的形式优选地为位于剂量标度套管上的外部凸缘,并适于接合与该壳体相关联的限制装置,该限制装置的形式优选地为位于壳体内的内部凸缘,以限制可用标度设定的最大剂量。 In another drive mechanism of the present embodiment of the invention, the drive mechanism having a first stop means, the stop means is preferably in the form of an external flange is located on the dose dial sleeve and adapted to engage with the limiting means associated with the housing, the restriction means is preferably in the form of an internal flange located within the housing, to limit the available scale setting of a maximum dose. 在本发明的驱动机构的又一实施例中,该驱动机构还具有第二止动装置,该止动装置的形式优选地为位于驱动套管上的外部凸缘,并适于接合限制装置,该限制装置的形式优选地为限制螺母,该螺母键接到该壳体上并安装成用于在该驱动套管的一外部带螺纹部分上旋转,以规定行程的终止点(an end of life stop)。 In yet another drive mechanism of the present embodiment of the invention, the drive mechanism further includes a second stop means, the stop means is preferably in the form of the driver on the outer flange bushing and adapted to engage limiting means, form the restriction device is preferably as limiting nut which bonded to the casing and mounted for rotation in an outer sleeve of the drive belt on the threaded portion to a predetermined end point of travel (an end of life stop).

本发明的第二个方面是提供一种用于给药装置的组件,该组件包括根据本发明的驱动机构。 A second aspect of the present invention is to provide components for a delivery device, the assembly comprising a drive mechanism according to the present invention.

本发明的第三个方面提供了一种给药装置,该给药装置包括根据本发明的驱动机构或组件。 A third aspect of the invention there is provided a delivery device, the medication administering device comprising the drive mechanism according to the present invention, or components.

本发明的第四个方面是提供一种组装给药装置的方法,该方法包括提供根据本发明的驱动机构或组件的步骤。 A fourth aspect of the present invention is to provide a method of assembling delivery device, the method comprising the step of providing a drive mechanism or the assembly according to the invention.

本发明的第五个方面是根据本发明的给药装置的应用,其用于分配药品,优选地分配包含选自胰岛素、生长激素、低分子量肝素以及它们的类似物和衍生物的活性化合物的药物配方(例如溶液、悬浮液等)。 A fifth aspect of the present invention is the application of the medication administering device of the present invention for dispensing a medicinal product preferably comprises the active compound is selected from distribution insulin, growth hormone, low molecular weight heparins, and their analogues and derivatives of pharmaceutical formulation (e.g. solution, suspension etc.).

附图说明 Brief Description

下面将结合一优选实施例并参照附图来更详细说明本发明,但这不作为任何限制,在该附图中:图1示出处于药筒装满的第一位置的根据本发明的给药装置的第一实施例的剖视图;图2示出处于最大的第一剂量被设定的第二位置的图1的给药装置的剖视图;图3示出处于最大的第一剂量被分配的第三位置的图1的给药装置的剖视图;图4示出处于最终的剂量被设定的第四位置的图1的给药装置的剖视图;图5示出处于最终的剂量被分配的第五位置的图1的给药装置的剖视图;图6示出图1的给药装置的第一细部的剖开立体图; Below in connection with a preferred embodiment and with reference to the drawings the present invention is described in more detail, but without any limitation, in the accompanying drawings in which: Figure 1 shows in a first position of the cartridge filled according to the present invention. a cross-sectional view of a first embodiment of the dosing device; Fig. 2 shows in a second position of the maximum of the first dose of the set of cross-sectional view of the medication administering device of FIG. 1; FIG. 3 shows a first maximum dose is dispensed sectional view of the medication administering device of the third position of Figure 1; Figure 4 shows the dose is set in the final position of the fourth cross-sectional view of the medication administering device of FIG. 1; FIG. 5 shows in a final dose dispensed first cross-sectional view of the five positions administering device of Figure 1; Figure 6 shows the dosing device of Figure 1 sectioned perspective view of a first detail;

图7示出图1的给药装置的第二细部的局部剖开立体图;图8示出图1的给药装置的第三细部的局部剖开立体图;图9示出增加用标度设定的剂量期间图1中所示的给药装置的部件的相对运动;图10示出减小用标度设定剂量期间图1中所示的给药装置的部件的相对运动;图11示出在分配剂量期间图1中所示的给药装置的部件的相对运动;图12示出处于最大第一剂量被设定的第二位置的图1的给药装置的局部剖开立体图;图13示出处于最终剂量被设定的第四位置的图1的给药装置的局部剖开立体图;图14示出处于第一、第三或第五位置之一的图1的给药装置的局部剖可立体图;图15示出图1的给药装置的主壳体的第一部分的剖开立体图;图16示出图1的给药装置的主壳体的第二部分的剖开立体图;图17示出处于药简装满的第一位置的根据本发明的驱动机构的第二实施例的剖视图;图18示出处于药筒装满的第一位置的根据本发明的给药装置的第三图24以放大比例示出图18的给药装置的另一段。 Figure 7 shows the administering device of the second detail in Figure 1 a partially cutaway perspective view; Fig. 8 shows a partial administering apparatus of a third detail of Figure 1 cut-away perspective view; Figure 9 shows an increase with scale setting relatively moving member delivery device shown in Figure 1 during a dose; Figure 10 shows the relative movement member is reduced during the administering device shown in FIG. 1 with the scale set dose; Figure 11 shows relatively moving parts in the administering device during the dose distribution shown in FIG. 1; FIG topical administration apparatus 12 is in a second position shows the maximum of the first dose is set cutaway perspective view of FIG. 1; FIG. 13 shows the final dose administering device in a fourth position is set in Fig. 1 a partial cutaway perspective view; Figure 14 shows the apparatus of FIG topical administration in the first, third or fifth position of one of the 1 cut-away perspective view of a second portion of the FIG. 16 shows the administering device in FIG. 1 the main housing;; cut-away perspective view of a first portion of the medication administering device in FIG. 15 shows the main housing of FIG. 1; the cross-sectional perspective view of can 17 shows a sectional view in full drug paperback first position according to a second embodiment of the drive mechanism of the present invention; Fig. 18 shows in a first position of the cartridge filled with medication administering device according to the third invention Figure 24 shows an enlarged scale section of another medication administering device 18 in FIG.

具体实施方式 DETAILED DESCRIPTION

示例1首先参照图1-5,其中示出处于多个位置的根据本发明的给药装置。 Example 1 Referring first to Figures 1-5, there is shown apparatus according to the present invention is administered in a plurality of positions.

该给药装置包括一壳体,该壳体具有第一药筒保持装置2,和第二主(外部)壳体部件4。 The medication administering device comprises a housing, the housing having a first cartridge retaining means 2 and a second main (exterior) housing part 4. 药筒保持装置2的第一端和主壳体4的第二端通过保持部件6固定在一起。 Cartridge holding means a first end and a second end 4 of the main housing 2 by the holding member 6 is fixed together. 在所示的实施例中,药筒保持装置2紧固在主壳体4的第二端内。 In the illustrated embodiment, the cartridge retaining means 2 secured within the second end of the main housing 4.

在药筒保持装置2内设置有药筒8,从该药筒可分配多种剂量的药品。 In the cartridge retaining means 2 is provided with a cartridge 8, from the drug cartridge dispensing multiple doses of drug. 活塞10被保持在药筒8的第一端内。 Piston 10 is held within the first end of the cartridge 8.

活动盖12被可释放地保持在药筒保持装置2的第二端上。 Movable lid 12 is releasably held in the second end of the cartridge retaining means 2. 在使用时,活动盖12可被使用者用合适的针组件(未示出)代替。 In use, the movable cover 12 may be replaced by a user with a suitable needle assembly (not shown). 可更换的盖14用于覆盖从主壳体4延伸的药筒保持装置2。 Replaceable holding cover 14 for covering the main housing 4 extending from the cartridge unit 2. 优选地,可更换的盖14的外部尺寸接近或等于主壳体4的外部尺寸,以便在该可更换的盖14处于覆盖药筒保持装置2的位置时进行整体压印。 Preferably, the outer dimensions of the replaceable cap 14 is close to or equal to the outer dimensions of the main housing 4, so that the replaceable cap 14 is covering the cartridge retaining position when the platen 2 the overall apparatus.

在所示的实施例中,一插入件16设置在主壳体4的第一端处。 In the embodiment shown, an insert 16 is provided at a first end of the main housing 4. 插入件16被固定,从而不能进行旋转或纵向运动。 Insert member 16 is fixed, and thus can not be rotated or longitudinal movement. 插入件16具有一从中穿过的带螺纹的圆形开口18。 A threaded insert member 16 having a circular opening therethrough of 18. 可选择地,该插入件可与主壳体4一体地形成,并且形式为具有内部螺纹的沿径向向内定向的凸缘。 Alternatively, the insert may be formed integrally with the main housing 4, and is in the form of an internal thread having a radially inwardly directed flange.

第一螺纹19从活塞杆20的第一端延伸。 The first thread 19 extends from a first end of the piston rod 20. 活塞杆20的截面通常为圆形。 Cross-section of the piston rod 20 is generally circular. 活塞杆20的第一端延伸通过插入件16中的带螺纹的开口18。 A first end of the piston rod 20 extends through the insert 16 in a threaded opening 18. 压脚22位于活塞杆20的第一端上。 Presser foot 22 is located on the first end 20 of the rod. 压脚22设置成紧靠药筒的活塞10的第二端。 The presser foot 22 is arranged close to the second end of the cartridge piston 10. 第二螺纹24从活塞杆20的第二端延伸。 Second thread 24 extends from a second end of the piston rod 20. 在所示的实施例中,第二螺纹24包括多个部分螺纹而不是一个全螺纹。 In the illustrated embodiment, the second threaded portion 24 includes a plurality of threads rather than a full thread. 所示的实施例较容易制造,并且有助于降低在分配药品时由使用者致动该装置所需的全部力。 Illustrated embodiment is easy to manufacture than, and in the distribution of drugs help reduce actuated by a user of the apparatus all the force required.

第一螺纹19和第二螺纹24相反地设置。 The first thread 19 and second thread 24 disposed opposite. 活塞杆20的第二端具有接纳凹槽26。 The second end 20 having a piston rod receiving recess 26.

驱动套管30围绕活塞杆20延伸。 The drive sleeve 30 extends around the piston rod 20. 驱动套管30通常为圆筒形。 The drive sleeve 30 is generally cylindrical. 驱动套管30在第一端具有沿径向延伸的第一凸缘32。 Drive sleeve 30 at a first end of the first flange 32 having a radially extending. 沿径向延伸的第二凸缘34沿驱动套管30与第一凸缘32相隔一定距离设置。 A second radially extending flange 34 along the drive sleeve 30 and the flange 32 spaced from the first set. 中间螺纹36设置在驱动套管30的外部部分上并在第一凸缘32和第二凸缘34之间延伸。 Intermediate thread 36 is provided on the drive sleeve 30 and an outer portion extending between the first flange 32 and second flange 34. 螺旋形凹槽(螺纹)38沿驱动套管30的内表面延伸。 Helical groove (thread) 38 along the inner surface 30 of the drive sleeve extends. 活塞杆20的第二螺纹24适于在该螺旋形凹槽38内行进。 The second thread 24 of the piston rod 20 is adapted to travel in the helical grooves 38.

第一凸缘32的第一端适于与插入件16的第二侧相适应。 The second side of the first flange of the first end 32 of the insert 16 is adapted to fit.

螺母40位于驱动套管30和主壳体2之间,并设置在第一凸缘32和第二凸缘34之间。 Nut 40 is located between the two drive sleeve 30 and the main housing, and is disposed between the first flange 32 and second flange 34. 在所示的实施例中,螺母40是对开螺母。 In the embodiment shown, the nut 40 is split nuts. 这样有助于该装置的装配。 This will help assembly of the apparatus. 螺母40的内螺纹与中间螺纹36相匹配。 Internal thread 40 of the nut screw 36 and the intermediate match. 螺母40的外表面与主壳体4的内表面通过花键42连接在一起(图10、11、15和16),以防止在螺母40和主壳体4之间发生相对旋转,同时允许在它们之间进行相对的纵向运动。 The inner surface of the outer surface of the nut 40 and the main housing 4 is connected by a spline 42 together (Fig. 10,11,15 and 16), to prevent relative rotation between the nut 40 and the main housing 4, while allowing relative longitudinal movement therebetween.

在驱动套管30的第二端和设置在驱动套管30的第二端处的延伸部38之间形成肩部37。 In between the second end of the extending portion 30 of drive sleeve 38 is formed of a second end of the drive sleeve 30 and the shoulder 37 disposed. 与驱动套管30的其余部分相比,延伸部38的内径和外径均减小。 Compared to the rest of the drive sleeve 30, the extension portion 38 of the inner and outer diameters are reduced. 延伸部38的第二端具有一沿径向向外定向的凸缘39。 Extending a second end portion 38 has a radially outwardly directed flange 39.

响声器50和离合器60在驱动套管30和剂量标度套管70(下文将说明)之间围绕驱动套管30设置。 Sound 50 and clutch 60 in the drive sleeve 30 and dose dial sleeve 70 (to be described later) between the drive sleeve 30 is provided around.

响声器50位于靠近驱动套管30的第二凸缘34处。 Sound (50) is located close to the drive sleeve 30. The second flange 34. 响声器50通常为圆筒形,并且在第一端具有柔性的螺旋形延伸的臂52(图6)。 Sound (50) is generally cylindrical, and has a flexible helically extending arm 52 (FIG. 6) at the first end. 臂52的一自由端具有沿径向定向的带齿构件54。 A free end of the arm 52 having a toothed member 54 along the radially oriented. 响声器50的第二端具有多个沿圆周定向的锯齿56(图7)。 Sound of the second end 50 has a plurality of circumferentially directed saw teeth 56 (FIG. 7). 每个锯齿包括一纵向定向表面和一倾斜表面。 Each saw tooth comprises a longitudinally directed surface and an inclined surface.

在一可选择的实施例(未示出)中,响声器还包括至少一个弹簧件。 In an alternative embodiment (not shown), the sound further comprises at least one spring member. 该至少一个弹簧件有助于在分配后使离合器60复位。 The at least one spring member helps the clutch 60 is reset after the allocation.

离合器60位于靠近驱动套管30的第二端处。 Clutch 60 is located close to the second end of the drive sleeve 30. 离合器60大致为圆筒形,并且在其第一端具有多个沿圆周定向的锯齿66(图7)。 Clutch 60 is generally cylindrical, and has a plurality of circumferentially directed saw teeth 66 (FIG. 7) at its first end. 每个锯齿包括一纵向定向表面和一倾斜表面。 Each saw tooth comprises a longitudinally directed surface and an inclined surface. 朝向离合器60的第二端64设置有沿径向向内定向的凸缘62。 Clutch 60 toward the second end 64 is provided with a radially inwardly directed flange 62. 离合器60的凸缘62位于驱动套管30的肩部37和延伸部38的沿径向向外定向的凸缘39之间。 The flange 60 of the flange 62 of the clutch shoulder 30 of the drive sleeve 37 and extending radially outwardly directed portion 38 between 39. 离合器60的第二端具有多个犬齿65(图8)。 The second end of the clutch 60 has a plurality of canine teeth 65 (FIG. 8). 离合器60通过花键(未示出)连接到该驱动套管30上,以防止在离合器60和驱动套管30之间发生相对旋转。 The clutch 60 is connected via splines (not shown) on the drive sleeve 30, between the clutch 60 to prevent the drive sleeve 30 and the relative rotation occurs.

在所示的实施例中,响声器50和离合器60均延伸驱动套管30的长度的大约一半。 In the illustrated embodiment, the sound device 50 and the clutch 60 each extend approximately half the length 30 of the drive sleeve. 但是,应理解关于这些部件的相对长度的其它设置也是可以的。 However, it should be understood that other settings regarding the relative lengths of these parts are possible.

响声器50和离合器60如图7中所示相接合。 And the clutch 60 shown in Fig. 7 (50) engages the sound.

剂量标度套管70设置在响声器50和离合器60的外部,并从主壳体4沿径向向内。 Dose dial sleeve 70 is provided outside the sound unit 50 and the clutch 60, and inwardly radially from the main housing 4. 螺旋形凹槽74围绕剂量标度套管70的外表面设置。 Helical groove 74 around the outer surface of the dose dial sleeve 70 is provided.

主壳体4具有一窗口44,通过该窗口可看到剂量标度套管的外表面的一部分。 The main housing 4 having a window 44, the window can be seen through a part of the dose dial sleeve outer surface. 主壳体4还具有螺旋形肋部(螺纹)46,其适于安置在剂量标度套管70的外表面上的螺旋形凹槽(螺纹)74内。 Main housing 4 also has a spiral rib (thread) 46, adapted to placed in the outer surface of the dose dial sleeve 70. The helical groove (thread) 74 within. 螺旋形肋部46延伸形成主壳体4的内表面上的单个曲线(single sweep)。 Helical rib single curve (single sweep) on the inner surface 46 of the main housing 4 formed to extend. 第一止动件100设置在花键42和螺旋形肋部46之间(图15)。 The first stopper 100 is provided on the spline 42 and between the helical rib 46 (FIG. 15). 第二止动件102由围绕主壳体4中的窗口44的框架形成,该第二止动件设置成与第一止动件100成180的角度(图16)。 The second stopper 102 is formed by a frame surrounding the window in the main housing 44 4, the second stopper disposed a first angle stopper 100 into 180 (Fig. 16).

方便地,可被用标度设定的剂量的可视标记例如参考数字(未示出)设置在剂量标度套管70的外表面上。 Conveniently, the scale can be used to set the amount of visual indicia such as reference numeral (not shown) provided on the dose dial sleeve 70 of the outer surface. 窗口44方便地仅允许看到当前被设定的剂量的可视标记。 Window 44 conveniently only allows to see the currently set dose of visual indicia.

剂量标度套管70的第二端具有形式为多个径向延伸件75的向内定向的凸缘。 Dose dial sleeve 70 of the second end having a plurality of radially extending member in the form of inwardly directed flange 75. 剂量标度夹持件76设置成围绕剂量标度套管70的第二端的外表面。 Dose dial holding member 76 disposed around the dose dial sleeve 70 of the outer surface of the second end. 剂量标度夹持件76的外径优选地等于主壳体4的外径。 Dose dial holding member 76 is preferably equal to the outer diameter of the outer diameter of the main housing 4. 剂量标度夹持件76固定在剂量标度套管70上以防止在它们之间发生相对运动。 Dose dial holding member 76 is fixed on the dose dial sleeve 70 to prevent relative movement therebetween. 剂量标度夹持件76具有中心开口78。 Dose dial holding member 76 having a central opening 78. 位于剂量标度夹持件76的第二端内的环形凹槽80围绕开口78延伸。 An annular groove located at the second end of the dose scale 80 of the clamping member 76 extends around the opening 78.

截面大致为“T”形的按钮82设置在该装置的第二端处。 Substantially sectional "T" shaped button 82 disposed at the second end of the apparatus. 按钮82的杆部84可延伸穿过剂量标度夹持件76中的开口78,并穿过驱动套管30的延伸部38的内径并进入活塞杆20的接纳凹槽26内。 Button 82 of the stem portion 84 may extend through the dose dial holding member 76 in the opening 78, and passes through the inner diameter of the drive sleeve 30 extending portion 38 and into the receiving recess 26 of the piston rod 20. 杆部84被保持成可在驱动套管30内进行受限的轴向运动,并且不能相对于该驱动套管旋转。 The lever portion 84 is held to be axially movable within the drive sleeve 30 is limited, and not with respect to the drive sleeve rotation. 按钮82的头部85大致为圆形。 The head 82 of the button 85 is generally circular. 围缘86从头部85的周向垂下。 Peripheral edge 86 from the head 85 in the circumferential direction hanging. 围缘86适于安置在剂量标度夹持件76的环形凹槽80内。 Peripheral edge 86 is adapted to reside in the dose dial holding member 76 within the annular recess 80.

下面将说明根据本发明的给药装置的操作。 Administering device will be described below in accordance with the present invention operation. 在图9、10和11中,箭头A、B、C、D、E、F和G分别代表按钮82、剂量标度夹持件76、剂量标度套管70、驱动套管30、离合器60、响声器50和螺母40的运动。 In Figure 9, 10 and 11, arrows A, B, C, D, E, F and G represent the button 82, the dose dial holding member 76, the dose dial sleeve 70, the drive sleeve 30, the clutch 60 , 50 and nut 40 sound movement.

为了用标度设定一个剂量(图9),使用者旋转剂量标度夹持件76(箭头B)。 To set a dose (Figure 9) with a scale, the user rotates the dose dial holding member 76 (arrow B). 通过响声器50和离合器60相接合,驱动套管30、响声器50、离合器60和剂量标度套管70与剂量标度夹持件76一起旋转。 50 by noise and clutch 60 engaged, the drive sleeve 30, 76 rotates together with the sound device 50, clutch 60 and the dose dial sleeve 70 and the dose dial holding member.

可通过响声器50和离合器60提供被设定的剂量的可听见的和可触知的反馈。 Provides the set dose by 50 and clutch 60 sound audible and tactile feedback. 通过锯齿56、66在响声器50和离合器60之间传递力矩。 By serrations 56, 66 transmit torque between sound 50 and clutch 60. 柔性臂52发生变形并在花键42上方拖动带齿构件54以产生卡嗒声。 Flexible arms 52 and 42 above deformed drag spline toothed member 54 to produce a clicking sound. 优选地,花键42设置成每个卡嗒声对应于一个常用的单位剂量或类似物。 Preferably, the splines 42 arranged to each click sound corresponds to a conventional unit dose, or the like.

剂量标度套管70上的螺旋形凹槽74和驱动套管30中的螺旋形凹槽38具有相同的导程。 Dose dial sleeve 74 and the helical groove 30 in the drive sleeve 70 on the helical grooves 38 have the same lead. 这使得剂量标度套管70(箭头C)可从主壳体4伸出,并且驱动套管30(箭头D)以同样的速度沿活塞杆20爬升。 This allows the dose dial sleeve 70 (arrow C) to extend from the main housing 4 and the drive sleeve 30 (arrow D) with the same speed along the piston rod 20 climb. 在行程的边界处,剂量标度套管70上的径向止动件104(图12)接合设置在主壳体4上的第一止动件100或第二止动件102,以阻止进一步移动。 Boundary in stroke, the dose dial sleeve 70 radially on the stopper 104 (FIG. 12) engaging the main housing 4 is provided on the movable member of the first stop 100 or the second stopper 102, to prevent further movement.

由于活塞杆20上的被放松的(overhauled)螺纹与被旋紧的(driven)螺纹的方向相反,因此可防止活塞杆20旋转。 Since the piston rod is relaxed (overhauled) with threads 20 on (driven) direction opposite to the thread is tightened, thereby preventing the piston rod 20 is rotated.

键接到主壳体4的螺母40由于驱动套管30的旋转(箭头D)而沿中间螺纹36前进。 Bonded to the nut 40 of the main housing 4 due to rotation of the drive sleeve 30 (arrow D) along the intermediate thread 36 proceeds. 当到达最终的剂量被分配的位置(图4、5和13)时,在螺母40的第二表面上形成的径向止动件106紧靠驱动套管30的第二凸缘34的第一表面上的径向止动件108,以便防止螺母40和驱动套管30进一步旋转。 Upon reaching the position (Figures 4, 5 and 13) the final dose dispensed, a second radial surface 40 on the nut formed on the stopper 106 abuts drive sleeve 30 of the second flange 34 of the first on the radial surface of the stopper member 108, so as to prevent further rotation of the nut 40 and the drive sleeve 30.

在一可选择的实施例(未示出)中,螺母40的第一表面具有用于紧靠设置在第一凸缘32的第二表面上的径向止动件的径向止动件。 In an alternative embodiment (not shown), the first surface of the nut 40 has a radial stop for abutment with a radial member on the second surface of the first flange 32 of the stopper. 这样有助于在装配该给药装置期间使螺母40位于药筒装满的位置。 This helps in the administering device during the assembly of the nut 40 is located in the cartridge loaded position.

如果使用者无意间用标度设定的剂量超过所需剂量,则该给药装置允许减小该剂量的设定而无需从药筒分配药品(图10)。 If the user inadvertently using the scale set dose than the desired dosage, the medication administering device allows reducing the dose setting without drug dispensed from the cartridge (FIG. 10). 使剂量标度夹持件76反向旋转(箭头B)。 So that the clamping member 76 the dose dial reverse rotation (arrow B). 这使该系统相反地起作用。 This makes the system function conversely. 柔性臂52防止响声器50旋转。 Flexible arm 52 to prevent rotation of the sound 50. 通过离合器60传递的力矩使锯齿56、66彼此跨过,从而产生对应于减小设定的剂量的卡嗒声。 Torque transmitted through the clutch 60 to make 56, 66 zigzag across each other, resulting in a corresponding decrease in the set dose clicks. 优选地,锯齿56、66设置成每个锯齿的圆周长度对应于一个单位剂量。 Preferably, the serrations 56, 66 disposed in a circumferential length of each saw tooth corresponds to a unit dose.

当已用标度设定所需剂量时,使用者可以随后通过按下按钮82来分配该剂量(图11)。 When the desired dose has been set by the scale, the user may then by assigning the dose (Fig. 11) by pressing the button 82. 这使离合器60相对于剂量标度套管70沿轴向移动,从而使犬齿65脱离接合。 This allows the clutch 60 with respect to the dose dial sleeve 70 moves axially, so that the canine 65 is disengaged. 但是,离合器60保持键接到驱动套管30,从而与其一起旋转。 However, the clutch 60 remains bonded to the drive sleeve 30, so as to rotate therewith. 剂量标度套管70和相关联的剂量标度夹持件76此时可自由旋转(由位于螺旋形凹槽74中的螺旋形肋部46引导)。 Dose dial sleeve 70 and dose dial associated clamping member 76 rotatably case (by helical grooves 74 located in the helical guide rib 46).

该轴向运动使响声器50的柔性臂52变形,以确保在分配期间锯齿56、66不能被放松。 The axial movement of the flexible arm 52 so that the sound is deformed 50, 56, 66 can not be serrated to ensure relax during the assignment. 这防止了驱动套管30相对于主壳体4旋转,但是驱动套管30仍可相对于主壳体4自由地轴向移动。 This prevents the drive sleeve 30 with respect to the main housing 4 is rotated, but the drive sleeve 30 with respect to the main housing 4 is still free to move axially. 此变形随后可用于沿驱动套管30推回响声器50和离合器60,以便当从按钮82去掉压力时恢复离合器60和剂量标度套管70之间的连接。 This deformation can then be used to push back along the drive sleeve 30 sound 50 and the clutch 60, so that when the recovery of the clutch 60 and the dose dial button 82 to remove pressure from the casing 70 is connected between.

驱动套管30的纵向轴向运动使活塞杆20穿过插入件16中的开口18而旋转,从而使活塞10在药筒8中前进。 The drive sleeve 30 causes longitudinal axial movement of the piston rod 20 is inserted through the opening 18 in the member 16 is rotated, so that the piston 10 advances in the cartridge 8. 一旦已分配所设定的剂量,就可通过使从剂量标度夹持件76延伸的多个构件110(图14)与在主壳体4中形成的对应的多个止动件112(图15和16)相接触,来防止剂量标度套管70进一步旋转。 Once the set dose has been allocated, by making possible a corresponding plurality of member 110 from a plurality (Fig. 14) a dose dial holding member 76 extending in the main casing 4 and the stopper 112 is formed (FIG. 15 and 16) in contact, to the dose dial sleeve 70 to prevent further rotation. 在所示的实施例中,构件110从剂量标度夹持件76沿轴向延伸,并具有一倾斜的端面。 In the embodiment shown, the member 110 from the dose dial holding member 76 extending axially along, and having an inclined end surface. 零剂量位置由构件110的沿轴向延伸的边缘之一紧靠对应的止动件112来确定。 One edge of the zero dosage position by the axially extending member 110 abuts against the corresponding stopper member 112 is determined.

示例2在本发明的另一个实施例中(图17),可以看到包括第二主壳体4'的驱动机构,该壳体具有第一端部和第二端部。 Example 2 In another embodiment of the present invention (FIG. 17), can be seen comprising a second main housing 4 'of the drive mechanism, the housing having a first end and a second end portion. 容纳药品的药筒可安装在该第二主壳体4'的第一端部上,并被任何合适的装置保持。 Containing medication cartridge may be mounted on the second main housing 4 'of the first end portion, and is maintained by any suitable means. 在所示的实施例中未示出药筒及其保持装置。 In the illustrated embodiment, the cartridge is not shown in its holder. 该药筒可包含多种剂量的药品,并且通常还包含一个可移动的活塞。 The cartridge may contain multiple doses of drug, and usually also includes a movable piston. 该活塞的移动使得药品可从该药筒经由针头(也未示出)排出。 Movement of the piston so that drugs can be via a needle (also not shown) is discharged from the drug cartridge.

在所示的实施例中,在该主壳体4'内设置有插入件16'。 In the embodiment shown, the main housing 4 'is provided inside the insert 16'. 该插入件16'被固定,从而不能相对于第二主壳体4'进行旋转运动和轴向运动。 The insert 16 'is secured, and thus can not with respect to the second main housing 4' rotational movement and axial movement. 插入件16'具有从中穿过的一带螺纹的圆形开口。 The insert 16 'has a threaded circular opening extending therethrough. 可选择地,该插入件可与第二主壳体4'一体地形成。 Alternatively, the insert with the second main housing 4 'is integrally formed.

在第二主壳体4'内还设置有一内部壳体154。 In the second main housing 4 'is also provided with an inner casing 154. 该内部壳体154被固定,从而不能相对于第二主壳体4'进行旋转运动和轴向运动。 The internal housing 154 is fixed, and thus can not with respect to the second main housing 4 'rotational movement and axial movement. 内部壳体154具有一贯穿其长度的圆形开口,在该开口中形成多个纵向花键。 The internal housing 154 having a circular opening through its length, a plurality of longitudinal splines in the opening. 螺旋螺纹150沿内部壳体154的外圆柱面延伸。 Helical threads 150 along the outer cylindrical surface 154 of the inner casing extends 可选择地,该内部壳体可与该第二主壳体4'和/或插入件16'一体地形成。 Alternatively, the internal housing with the second main housing 4 'and / or insert member 16' is integrally formed.

第一螺纹19'从活塞杆20'的第一端部延伸。 The first thread 19 extending 'from the piston rod 20' of the first end portion. 该活塞杆20'的截面大致为圆形。 Section of the piston rod 20 'is generally circular. 活塞杆20'的第一端部穿过插入件16'中的带螺纹的开口,活塞杆20'的第一螺纹19'与插入件16'的螺纹相接合。 16 'the threaded rod 20' of a first end portion through the insertion member 16 'in the threaded opening, the piston rod 20' of a first thread 19 'and the insert engaged. 压脚22'位于活塞杆20'的第一端部上。 The presser foot 22 'is located in the piston rod 20' on the first end portion. 压脚22'设置成紧靠药筒活塞(未示出)。 The presser foot 22 'arranged close to the cartridge piston (not shown). 第二螺纹24'从活塞杆20'的第二端部延伸。 The second threaded section 24 extending 'from the piston rod 20' of the second end portion. 第一螺纹19'和第二螺纹24'相反地设置。 The first thread 19 'and the second thread 24' on the contrary provided.

驱动套管30'围绕活塞杆20'延伸。 Drive sleeve 30 'surrounds the piston rod 20' extends. 驱动套管30'通常为圆筒形。 Drive sleeve 30 'is generally cylindrical. 驱动套管30'在第一端部具有第一径向延伸的凸缘32'。 The drive sleeve 30 'at a first end portion having a first radially extending flange 32'. 沿驱动套管30'与第一凸缘32'相隔一定距离设置有第二径向延伸的凸缘34'。 Along the drive sleeve 30 'and the first flange 32' at a distance is provided with a second radially extending flange 34 '. 在驱动套管30'的外部部分上设置有外部螺旋螺纹(未示出),该外部螺纹在第一凸缘32'和第二凸缘34'之间延伸。 In the drive sleeve 30 'on the outer portion is provided with external screw thread (not shown), the outer thread of the first flange 32' and the second flange 34 'extends. 一内部螺旋螺纹沿驱动套管30'的内表面延伸。 An internal helical thread along the drive sleeve 30 'extending inner surface. 活塞杆20'的第二螺纹24'与驱动套管30'的内部螺旋螺纹相接合。 The piston rod 20 'of the second thread 24' and the drive sleeve 30 'engages the inner helical threads.

螺母40'位于驱动套管30'和内部壳体154之间,并设置在驱动套管30'的第一凸缘32'和第二凸缘34'之间。 Nut 40 'is located in the drive sleeve 30' and the internal housing 154, disposed between 'the first flange 32' of the drive sleeve 30 and the second flange 34 '. 螺母40'可以是“对开螺母”或“全高螺母”。 Nut 40 'can be "split nut" or "full-height nuts." 螺母40'具有与驱动套管30'的外部螺旋螺纹相接合的内部螺纹。 Nut 40 'has the drive sleeve 30' is engaged with the external helical thread of the internal thread. 螺母40'的外表面和内部壳体154的内表面通过纵向花键连接在一起,以防止螺母40'和内部壳体154之间发生相对旋转,同时允许它们之间发生相对纵向运动。 Nut 40 'and the inner surface of the outer surface of the inner casing 154 are connected together by longitudinal splines to prevent the nut 40' and the internal housing 154 between the relative rotation, while permitting relative longitudinal movement between them.

响声器50'和离合器60'围绕驱动套管30'设置,并位于驱动套管30'和内部壳体154之间。 Sound 50 'and the clutch 60' around the drive sleeve 30 'is set, and is located in the drive sleeve 30' and between the inner casing 154.

响声器50'靠近驱动套管30'的第二凸缘34'设置。 Sound 50 'close to the drive sleeve 30' of the second flange 34 'is provided. 响声器50'包括至少一个弹簧元件(未示出)。 Sound device 50 'comprises at least one spring element (not shown). 响声器50'还包括一组设置成朝向该驱动机构的第二端部的具有三角形状的齿(未示出)。 Sound 50 'also includes a set of triangular teeth disposed toward the second end portion of the drive mechanism (not shown). 当被压缩时,该响声器50'的至少一个弹簧元件在驱动套管30'的凸缘34'和离合器60'之间施加轴向力。 Applying an axial force when compressed between the noise filter 50 'is at least one spring element in the drive sleeve 30' of flange 34 'and the clutch 60'. 响声器50'的外表面和内部壳体154的内表面通过纵向花键连接在一起,以防止响声器50'和内部壳体154之间发生相对旋转,同时允许它们之间发生相对纵向运动。 Sound 50 'and the inner surface of the outer surface of the inner casing 154 are connected together by longitudinal splines to prevent noise 50' between the inner casing 154 and relative rotation, while permitting relative longitudinal movement between them.

离合器60'靠近驱动套管30'的第二端部设置。 Clutch 60 'is close to the drive sleeve 30' of the second end portion. 离合器60'大致为圆筒形,并且在其第一端部具有多个围绕圆周设置的三角形状的齿(未示出),该齿作用在响声器50'的齿上。 Clutch 60 'is substantially cylindrical and has a plurality of circumferentially disposed around the triangular teeth (not shown) at its first end portion, the noise in the tooth 50' of the tooth. 朝向离合器60'的第二端部设有肩部158。 Toward the clutch 60 'of the second end portion provided with a shoulder 158. 离合器60'的肩部158设置在内部壳体154和剂量标度夹持件76'(下面将说明)的径向向内的凸缘之间。 Clutch 60 'shoulder 158 provided in the inner casing 154 and the dose dial holding member 76' between the radially inwardly directed flange (described below) of. 离合器60'的肩部158具有多个沿该驱动机构的第二端部的方向延伸的犬齿(未示出)。 Clutch 60 'shoulder portion 158 having a plurality of fangs along the direction of the drive mechanism of the second end portion extending (not shown). 离合器60'通过花键(未示出)连接在驱动套管30'上,以防止离合器60'和驱动套管30'之间发生相对旋转。 Clutch 60 'is connected by means of splines (not shown) in the drive sleeve 30', in order to prevent the clutch 60 'and the drive sleeve 30' relative rotation.

剂量标度套管70'设置在内部壳体154外部,并从第二主壳体4'沿径向向内。 Dose dial sleeve 70 'is provided in the interior of the housing 154 outside, and from the second main housing 4' radially inwardly. 在剂量标度套管70'的内表面上设置有螺旋螺纹。 Is provided with a helical thread on the dose dial sleeve 70 'of the inner surface. 该剂量标度套管70'的螺旋螺纹与内部壳体154的螺旋螺纹150相接合。 The dose dial sleeve 70 'and the internal helical thread of the screw thread 154 of the housing 150 engage.

第二主壳体4'具有一窗口(未示出),通过该窗口可看到剂量标度套管70'的外表面的一部分。 The second main housing 4 'having a window (not shown), can be seen through the window dose dial sleeve 70' a portion of the outer surface. 方便地,在剂量标度套管70'的外表面上设有可用标度设定的剂量的可视标记例如参考数字(未示出)。 Conveniently, the dose dial sleeve 70 'is provided with an outer surface of the available scale set dose of visual indicia such as reference numeral (not shown). 方便地,第二主壳体4'的窗口仅允许看到目前被用标度设定的剂量。 Conveniently, 4 'of the window of the second main housing to be used to allow only see the current scale setting of the dose.

剂量标度夹持件76'位于朝向该驱动机构的第二端部处。 Dose dial clamping member 76 'is located at the second end portion toward the drive mechanism. 该剂量标度夹持件76'被固定,从而不能相对于该剂量标度套管70'进行旋转运动和轴向运动。 The dose dial holding member 76 'is fixed, and thus can not with respect to the dose dial sleeve 70' rotational movement and axial movement. 剂量标度夹持件76'具有一沿径向向内的凸缘160。 Dose dial holding member 76 'having a flange 160 radially inwardly. 剂量标度夹持件76'的沿径向向内的凸缘160具有多个犬齿(未示出),该犬齿沿该驱动机构的第一端部的方向延伸以紧靠离合器60'的犬齿。 Dose dial holding member 76 'radially inward flange 160 having a plurality of canines (not shown), which extends against canine clutch 60 along the direction of the first end portion of the drive mechanism' canines . 剂量标度夹持件76'的犬齿与离合器60'的犬齿的接合和脱离接合可在剂量标度夹持件76'和离合器60'之间提供一可释放的离合器。 Dose dial holding member 76 'and the clutch 60 canines apos canines and out of engagement provides a releasable clutch between the dose dial holding member 76' and the clutch 60 '.

在该驱动机构的第二端部处设置有横截面大致为“T”形的按钮82'。 The second end portion of the drive mechanism is provided with a cross-section substantially "T" shaped button 82 '. 按钮82'的圆柱形部件朝该驱动机构的第一端部延伸,穿过剂量标度夹持件76'内的开口并进入驱动套管30'的凹槽内。 Button 82 'of the cylindrical member toward the first end portion of the drive mechanism extending through the holding member 76 dose dial' within the opening and into the drive sleeve 30 'of the grooves. 按钮82'的圆柱形部件被保持成可在驱动套管30'内进行有限的轴向运动并且不能相对于该驱动套管旋转。 Button 82 'of the cylindrical member is held in the drive sleeve 30' of limited axial movement and not with respect to the drive sleeve rotation. 按钮82'的圆柱形部件具有沿径向延伸的凸出部(未示出),该凸出部紧靠离合器60'的肩部158的第二表面。 Shoulder button 82 'is a cylindrical member having a projecting portion (not shown), the projecting portion abuts radially extending clutch 60' of the second surface 158. 按钮82'的第二端部大致为圆形,并且围绕其周向具有朝该驱动机构的第一端部向下延伸的圆筒形围缘(skirt)。 The second end portion button 82 'is generally circular and has a circumferentially extending around its downwardly toward the first end portion of the driving mechanism of a cylindrical peripheral edge (skirt). 按钮82'的围缘位于从剂量标度夹持件76'沿径向向内的位置。 Button 82 'is located around the edge of the holding member from the dosage scale 76' radially inward position.

下面将说明根据本发明的驱动机构的操作。 Will be described below in accordance with the driving mechanism of the present invention operate.

为了用标度设定一个剂量,使用者旋转该剂量标度夹持件76'。 To set a dose with the scale, the user rotates the dose dial holding member 76 '. 响声器50'的弹簧元件沿该驱动机构的第二端部的方向向离合器60'施加轴向力。 Sound 50 'of the spring element in the direction of the second end portion of the drive mechanism to the clutch 60' is applied to an axial force. 响声器50'的弹簧元件施加的力使离合器60'的犬齿与剂量标度夹持件76'的犬齿相接合以便进行旋转。 Sound 50 'force exerted by the spring element of the clutch 60' canine dose scale clamping member 76 'canine teeth for engaging rotation. 当剂量标度夹持件76'旋转时,相关联的剂量标度套管70'、驱动套管30'和离合器60'均一致地发生旋转。 When the dose dial holding member 76 'is rotated, the associated dose dial sleeve 70', the drive sleeve 30 'and the clutch 60' are rotating in unison occurs.

通过响声器50'和离合器60'提供剂量被用标度设定的声音和触觉反馈。 By sound 50 'and the clutch 60' is provided with a dose setting scale sound and tactile feedback. 当离合器60'旋转时,从离合器60'的第一端部处的齿和响声器50'的齿传递力矩。 When the clutch 60 'is rotated, the clutch 60' and the teeth of the sound at the first end portion 50 'of the transmission torque. 响声器50'不能相对于内部壳体154旋转,由此响声器50'的至少一个弹簧元件变形,以允许离合器60'的齿越过响声器50'的齿而产生可听见的和可触知的“卡嗒声”。 Sound 50 'not rotating with respect to the internal housing 154, whereby the noise 50' of the at least one spring element is deformed to allow the clutch 60 'over the sound teeth 50' of the teeth to produce an audible and tactile "clicks." 优选地,响声器50'的齿和离合器60'的齿设置成使得每个“卡嗒声”对应于药品或类似物的常规单位(剂量)。 Preferably, the sound device 50 'and clutch teeth 60' are arranged such that each of the teeth "clicks" corresponding to the drug or the like conventional units (dose).

剂量标度套管70'的螺旋螺纹和驱动套管30'的内部螺旋螺纹的导程相同。 Dose dial sleeve 70 'and the screw threaded drive sleeve 30' internal helical thread of the same lead. 这使得剂量标度套管70'沿内部壳体154的螺纹150前进的速率与驱动套管30'沿活塞杆20'的第二螺纹24'前进的速率相同。 This allows the same dose dial sleeve 70 'along the threaded internal rate of 154 150 housing forward and drive sleeve 30' along the rod 20 'of the second thread 24' speed forward. 由于活塞杆20'的第一螺纹19'与第二螺纹24'方向相反,因此可防止活塞杆20'旋转。 Since the piston rod 20 'of a first thread 19' and the second thread 24 'in the opposite direction, thereby preventing the piston rod 20' to rotate. 活塞杆20'的第一螺纹19'与插入件16'的螺纹相接合,从而在用标度设定一个剂量时活塞杆20'不会相对于第二主壳体4'移动。 16 the piston rod 20 'of a first thread 19' and the insert & apos thread engagement, so that when setting a dose scale with the piston rod 20 'is not relative to the second main housing 4' to move.

连接到该内部壳体154上的螺母40'由于驱动套管30'的旋转而沿驱动套管30'的外部螺纹前进。 Connected to the interior of the housing 154 on the nut 40 'due to the drive sleeve 30' to rotate along the drive sleeve 30 'of the external thread forward. 当使用者用标度设定的药品的量等于药筒可输送的量时,螺母40'到达一个位置,在该位置螺母40'紧靠驱动套管30'的第二凸缘34'。 When the amount of the user with the scale setting of the drug cartridge may be equal to the amount delivered, the nut 40 'reaches a position in which the position of the nut 40' against the drive sleeve 30 'of the second flange 34'. 在螺母40'的第二表面上形成的径向止动件与驱动套管30'的第二凸缘34'的第一表面上的径向止动件接触,以便防止螺母40'和驱动套管30'进一步被旋转。 In the nut 40 'is formed radially on the second surface of the stopper member and the drive sleeve 30' of the second flange 34 'radial stop member on the first surface of the contact, in order to prevent the nut 40' and the drive sleeve Tube 30 'is further rotated.

如果使用者无意间用标度设定的量大于所需剂量,则该驱动机构允许纠正该剂量而不用从药筒分配出药品。 If the amount of inadvertently using the scale set by the user to the desired dosage, the drive mechanism allows the correct dose without drug dispensed from the cartridge. 将剂量标度夹持件76'反向旋转。 The dose dial reverse rotation holding member 76 '. 这使得该系统相反地工作。 This allows the system oppositely. 通过离合器60'传递的力矩使离合器60'的第一端部处的齿越过响声器50'的齿,以产生对应于减小用标度设定的剂量的卡嗒声。 Through the clutch 60 'transmitted torque to clutch 60' at the first end portion over the sound tooth 50 'of the teeth, to produce reduced by the scale corresponding to the set dose of the click sound.

当已用标度设定所需的剂量时,使用者随后可通过沿该驱动机构的第一端部的方向按下按钮82'来分配此剂量。 When the desired dose has been set by the scale, the user may then press the button 82 along the direction of the first end portion of the drive mechanism of the 'dispense this dose. 按钮82'的凸出部向离合器60'的肩部158的第二表面施加压力,使离合器60'相对于剂量标度夹持件76'沿轴向移动。 Applying shoulder 'projections to the clutch 60' button 82 of the second surface 158 of the pressure, the clutch 60 'with respect to the dose dial holding member 76 to move axially. 这使离合器60'的肩部158上的犬齿与剂量标度夹持件76'的犬齿脱离接合。 'Canine dose scale clamping member 76 on the shoulder 158' canines which the clutch 60 is disengaged. 但是,离合器60'仍保持与驱动套管30'连接,从而不能相对旋转。 However, the clutch 60 'remains with the drive sleeve 30' is connected, and thus incapable of relative rotation. 此时,剂量标度夹持件76'和相关联的剂量标度套管70'可自由旋转(由内部壳体154的螺旋螺纹150引导)。 At this time, the dose dial holding member 76 'and associated dose dial sleeve 70' is free to rotate (by the helical thread 154 of the internal housing 150 boot).

离合器60'的轴向运动使响声器50'的弹簧元件变形,并且使离合器60'的第一端部处的齿与响声器50'的齿相接合,以便防止它们之间相对旋转。 Clutch 60 'so that axial movement of the sound device 50' of the spring element is deformed, and the clutch 60 'and the teeth of the sound at the first end portion 50' engages the teeth, so as to prevent relative rotation therebetween. 这样可防止驱动套管30'相对于内部壳体154旋转,但是该驱动套管仍可相对于该内部壳体沿轴向自由移动。 This prevents the drive sleeve 30 'with respect to the rotation of the internal housing 154, but still the drive sleeve with respect to the internal housing is free to move axially.

从而,施加在按钮82'上的压力使剂量标度夹持件76'和相关联的剂量标度套管70'旋转进入第二主壳体4'内。 Thus, applied to the button 82 'so that the pressure on the dose dial holding member 76' and associated dose dial sleeve 70 'rotated into the second main housing 4 & apos ;. 在此压力下,离合器60'、响声器50'和驱动套管30'沿该驱动机构的第一端部的方向轴向移动,但是它们并不旋转。 At this pressure, the clutch 60 ', the sound device 50' and the drive sleeve 30 'is moved in the axial direction of the first end portion of the drive mechanism, but they do not rotate. 驱动套管30'的轴向运动使活塞杆20'旋转通过插入件16'中的带螺纹的开口,从而使压脚22'前进。 Drive sleeve 30 'so that axial movement of the piston rod 20' is rotated by the insert member 16 'in the threaded opening, so that the presser foot 22' proceeds. 这样向活塞施加力,使得可从药筒排出药品。 Such a force is applied to the piston, so that drugs can be discharged from the cartridge. 当剂量标度夹持件76'返回其紧靠第二主壳体4'的位置时,该选定的剂量被输送出来。 When the dose dial holding member 76 'to return it stops at the second main housing 4' position, the selected dose is delivered out.

当从按钮82'除去压力时,利用响声器50'的弹簧元件的变形将离合器60'沿驱动套管30'推回,以使离合器60'的肩部158上的犬齿与剂量标度夹持件76'上的犬齿重新接合。 When the button 'removal of the pressure, utilizing sound 50' of the deformation of the spring element 82 of the clutch 60 'along the drive sleeve 30' is pushed back, so that the clutch 60 'with the canine shoulder 158 on the dose dial grip canines' 76 on re-engaging. 从而该驱动机构被重置,以准备用标度设定随后的剂量。 The drive mechanism is thus reset in preparation to set the dose with subsequent scale.

示例3参照图18-22,可见根据本发明的一给药装置。 Example 3 Referring to FIG. 18-22, showing the present invention in accordance with an administration apparatus. 该给药装置包括一两分壳体2”,在该壳体内设置有容纳药品的药筒4”,用于设定或选定将被排出的药品的剂量的装置,以及用于排出该选定剂量的药品的装置。 The medication administering device comprises a housing 2 of two points ", disposed within the housing to accommodate the drug cartridge 4", or to be discharged for setting a dose of drug selection means, and means for discharging the selected unit doses of drugs. 壳体2”的形状大致为圆筒形并容纳齿条6”,下文将更详细地说明该齿条。 Housing 2 "is generally cylindrical shape and accommodating rack 6", will be described in more detail below the rack. 药筒4”位于壳体2”的第一部分8”内。该剂量设定装置和用于排出选定剂量的药品的装置被保持即限制在壳体2”的第二部分10”内。壳体2”的第一部分8”与壳体2”的第二部分10”可通过任何合适的装置固定在一起。 The cartridge 4 "is located in the housing 2" in the first part 8 ". The dose setting means and means for discharging the selected amount of drug that is limiting device is held in the housing 2" of the second part 10 "within. Shell body 2 "of the first portion 8" of the housing 2 'of the second portion 10' may be secured together by any suitable means.

药筒4”可通过任何合适的装置固定在壳体2”的第一部分8”内的适当位置处。针组件可固定在药筒4”的第一端上。 8 cartridge 4 "may be secured by any suitable means in the housing 2" in the first part of the "appropriate position within the needle assembly can be fixed in the cartridge 4" of the first end. 在附图中在此位置示出临时盖12”。药筒4”还包括可移动的活塞14”。使活塞10”朝药筒4”的第一端前进可使药品通过该针组件从药筒4”排出。 In the drawings is shown in this position the temporary cover 12. "Cartridge 4" further comprises a displaceable piston 14. "Piston 10" towards the cartridge 4 "allows a first end of the drug through the needle advancing assembly from the drug tube 4 "discharge. 可设置盖16”以便在该给药装置不使用时覆盖该针组件。盖16”可通过任何合适的装置可释放地固定在壳体2'上。 Can be set to cover 16 'so as to cover the needle assembly when the administering device is not used. Cover 16 "may be fixed at 2' to the housing by any suitable means releasably.

下面将更详细地说明剂量设定装置和用于排出选定剂量的药品的装置。 Will now be described in detail a selected dose setting means and the discharge means for the dose of medicine. 齿条6”设置在位于壳体2”中的驱动套管18”内,并通过任何合适的装置相对于壳体2”轴向固定和旋转固定。 Drive rack 6 "is provided in the housing 2" in the casing 18 'inside, and by any suitable means relative to the housing 2 "axially fixed and rotationally fixed. 驱动套管18”包括一内部带螺纹的部分20”,其基本沿该套管的整个内表面延伸。 Drive sleeve 18 "comprises an internally threaded portion 20", substantially along its entire inner surface of the sleeve extends. 一内部齿轮22”位于驱动套管18”内,并具有与驱动套管18”的内部螺纹的节距相匹配的螺旋形齿。驱动套管18”的内部螺纹是多头螺纹,其导程等于剂量标度套管的螺旋螺纹的导程,下文将对该剂量标度套管进行说明。 An internal gear 22 "is located in the drive sleeve 18" inside, and having a drive sleeve 18 "matches the inner thread pitch helical gear. The drive sleeve 18" of the internal threads are multi-start thread, which is equal to the lead dose dial sleeve lead screw threads, below the dose dial sleeve will be described. 驱动套管18”的终端为一外部带螺纹的区段24”,其从该套管的端部一直延伸到从驱动套管18”凸出的外部圆周凸缘26”。 "Section for an external threaded end 24 'of the drive sleeve 18, which extends from an end portion of the sleeve to the drive sleeve 18" external circumferential flange 26 protruding. " 一限制螺母28”被安装以便在套管14”的外部带螺纹的区段24”上旋转。该限制螺母28”通过多个纵向延伸的花键30”连接到壳体2”上,该花键沿壳体2”的第一部分8”的内表面延伸。 A limit nut 28 "is mounted so that the sleeve 14" external threaded section 24 "rotating. The limit nut 28 'through a plurality of longitudinally extending splines 30" is connected to the housing 2 "on the flower key along the housing 2 "of the first portion 8" of the inner surface extends. 在所示实施例中,限制螺母28”示出为对开螺母,但是也可使用全高螺母。 In the illustrated embodiment, the limiting nut 28 "is shown as a half-nut, but can also be used full height nut.

活塞杆32”设置成沿齿条6”的长度延伸并穿过齿条6”的端部内的孔。活塞杆32”大体是细长的,并且具有压脚34”。在使用时,压脚34”设置成紧靠药筒活塞14”。齿轮22”在轴颈轴承(未示出)中安装在远离压脚34”的活塞杆32”的端部上。 The piston rod 32 'arranged along the rack 6 "and extends the length of the rack 6 through the" end of the bore within the piston rod 32 "is generally elongate, and has a presser foot 34." In use, the presser foot 34 'arranged close to the cartridge piston 14 "piston rod 32" end portion "(not shown) mounted on the journal bearing 34 away from the presser foot" The gear 22.

大致为圆筒形的剂量标度套管36”包括具有第一直径的第一部分38”和具有较大的第二直径的第二部分40”。该第一部分位于壳体2”内。 A substantially cylindrical dose dial sleeve 36 "comprises a first portion having a first diameter 38 'and the second having a larger diameter second portion 40." The first part of the housing 2 ".

优选地,剂量标度套管36”的第二部分40”的外径与壳体2”相同。壳体2”的第二部分10”包括一围绕同轴的内部套管部分44”的外部套管部分42”。该外部套管部分42”在圆形内部凸缘部分46”处封闭到该内部套管部分44”。 2 "is the same as the housing 2" Preferably, the dose dial sleeve 36 "of the second portion 40" of the outer diameter of the second portion of the housing 10 'includes a surrounding coaxial internal sleeve portion 44 "of the outer sleeve portion 42. "The external sleeve portion 42" at a circular internal flange portion 46 "at the closed to the internal sleeve portion 44." 剂量标度套管36”的第一部分38”位于壳体2”的第二部分10”内,并位于外部套管部分42”和内部套管部分44”之间。 Dose dial sleeve 36 "of the first portion 38" located within the housing 2 "of the second portion 10 ', and located outside the sleeve portion 42" and the internal sleeve portion 44 "between. 第一部分38”的内表面和内部套管部分44”的外表面具有互相接合的部件,以便在壳体2”的第二部分10”的内部套管部分44”和剂量标度套管36”之间形成螺旋螺纹48”。如上所述,该螺旋螺纹48”的导程与驱动套管18”的内部螺纹相同。设置在剂量标度套管36”的内表面上的螺旋形肋部可在螺旋形轨道内行进。 The first portion 38 'and the inner surface of the inner sleeve portion 44 "of the outer surface of the engaging member with each other, so that the interior of the housing 2" of the second portion 10 "of the sleeve portion 44" and the dose dial sleeve 36 " helical thread 48 formed between. "As described above, the helical thread 48" 'the same internal threads. provided the dose dial sleeve 36 "and drive sleeve lead of the helical rib 18 on the inner surface of the can traveling in a spiral track. 这样可使剂量标度套管36”围绕并沿壳体2”旋转。 This allows the 36 "around and along the housing 2" Rotate dose dial sleeve.

剂量标度套管36”的第二部分40”具有靠近其自由端的端壁50”,这样在该端壁50”和剂量标度套管36”的自由端之间限定一中央接纳区域52”。 Dose dial sleeve 36 "of the second portion 40" having "defining a central receiving area 52 between the free ends of" near its free end of the end wall 50 ", so that in the end wall 50" and the dose dial sleeve 36 . 在端壁50”内设置有通孔54”。 In the end wall 50 "provided with the through-holes 54." 设置一大致为“T”形构造的剂量按钮56”,该按钮的头部58”被保持在接纳区域52”内,并且该按钮的杆部60”的尺寸制成可通过该通孔54”。按钮56”的杆部60”具有多个指爪62”,该指爪可变形以便仅在远离剂量标度套管36”的自由端的方向上通过端壁50”的通孔54”。 Providing a substantially "T" shaped configuration of the dose button 56 ", the head of the button 58" is held in the receiving area 52 ", the lever portion 60 and the button" formed by the size of the through hole 54 " The button 56 "of the lever portion 60" has a plurality of claws 62 ', the claws can be deformed so far only at the dose dial sleeve 36 "on the direction of the free end through the end wall 50" of the through-holes 54. "

驱动套管18”在其远离该外部带螺纹的区段24”的一端被穿孔的端壁64”封闭,多个接合部件66”从该端壁突出到驱动套管18”之外。 The drive sleeve 18 "in its remote from the external threaded segment 24 'is perforated at one end of the end wall 64" closed, a plurality of engaging members 66' projecting from the end wall to the drive sleeve 18 "outside.

基本为U形的锁紧弹簧68”设置成沿纵向安装在驱动套管18”的外部,该锁紧弹簧包括通过连接部分74”连接的第一和第二支脚70”、72”。连接部分74”的长度基本等于驱动套管18”的外径。锁紧弹簧68”的支脚70”、72”中的每一个的终端均为一插销部分(latch portion)76”,下文将说明该插销部分的功能。 A substantially U-shaped locking spring 68 "disposed longitudinally mounted in the drive sleeve 18" outside, by the locking spring comprises a connecting portion 74 'connecting the first and second legs 70 ", 72." Connecting portion 74 "in length substantially equal to the drive sleeve 18" outside diameter of the locking spring 68 "legs 70", 72 "of each of the terminal are a latch portion (latch portion) 76", the latch will be described hereinafter part of the function.

当组装该装置时,锁紧弹簧68”朝剂量标度套管36”的端壁50”的内部推动剂量按钮56”沿轴向远离活塞杆32”和驱动套管18”。 When assembling the device, locking spring 68 "toward the dose dial sleeve 36" of the end wall 50 "internal dose push button 56" axially away from the piston rod 32 "and drive sleeve 18." 在此位置,剂量按钮56”被锁定成与剂量标度套管36”一起旋转。 In this position, the dose button 56 "is locked to the dose dial sleeve 36" to rotate together. 剂量按钮56”同时被永久锁定成与驱动套管18”一起旋转。 Dose button 56 "while being permanently locked into the drive sleeve 18" rotate together.

剂量标度套管36”的第一部分的外表面具有图案82”。 Dose dial sleeve 36 "of the outer surface of the first portion 82 having a pattern." 该图案通常为一系列参考数字。 The pattern is typically a series of reference numbers. 壳体2”具有孔或窗口84”,通过该孔或窗口可看到代表由使用者选择的剂量值的图案的一部分。 Housing 2 'has a hole or window 84 "through the aperture or window can see part of the pattern selected by the user on behalf of dose values.

可通过任何合适的方法将图案82”加到剂量标度套管36”上。 By any suitable method "is applied to the dose dial sleeve 36" pattern 82. 图案82”可直接印制在剂量标度套管36”上,或设置成围绕剂量标度套管36”的印刷标签的形式。可选择地,图案的形式可以是夹在剂量标度套管36”上的带标记的套管。 Pattern 82 "may be printed directly on the dose dial sleeve 36" on, or disposed around the dose dial sleeve 36 "in the form of a printed label. Form Alternatively, the pattern may be sandwiched between the dose dial sleeve Tagged sleeve 36 "on. 可通过任何合适的方式例如激光刺点来标记图案。 Can, for example laser dot to mark pattern thorn by any suitable means.

从驱动套管18”突出的外部圆周凸缘26”具有一对沿直径相对的通孔78”,该通孔的尺寸制成可接纳锁紧弹簧68”的对应的插销部分76”。从凸缘26”的外边缘突出的响声器突出部80”与每个通孔78”相关联。 From the drive sleeve 18 'projecting outer circumferential flange 26 "has a pair of diametrically opposed through-holes 78", the size of the through hole can be made to accept the locking spring 68 "corresponding to the latching portion 76." From the convex Each through hole 78 "is associated flange 26" projecting portion 80 of the outer edge of the sound projection device. "

在图18中,给药装置具有一装满的药筒4”。为了操作该给药装置,使用者必须首先选择一个剂量。为了设定剂量,使剂量标度套管36”相对于壳体2”旋转,直到通过窗口84”可见所需的剂量值。 In Figure 18, the administration device filled with a cartridge (4). "In order to operate the delivery device, the user must first select a dose. To set a dose the dose dial sleeve 36 so that" with respect to the housing 2 "spin until 84 through the window," the required dose values visible. 驱动套管18”连接在剂量标度套管36”上,并且在用标度设定期间以相同的速度旋出。 Drive sleeve 18 "is connected to the dose dial sleeve 36" on, and during the setting scale at the same speed spin out. 在用标度设定一个剂量期间,锁紧弹簧68是直的,并朝剂量标度套管36”的端壁50”的内部推动剂量按钮56”沿轴向远离活塞杆32”和驱动套管18”,从而提供一离合器机构。因此,驱动套管18”在位于其内部的齿轮22”上方旋转。驱动套管18”和壳体2”之间的相对旋转使正在被用标度设定的剂量通过两个响声器突出部80”与花键30”的接合而生成声音确认,该花键沿壳体2”的第一部分8”的内表面延伸。 With a dose setting scale period, the locking spring 68 is straight, and the dose dial sleeve 36 toward the "end wall 50" of the dose inside push button 56 "axially away from the piston rod 32" and drive sleeve tube 18 ", thereby providing a clutch mechanism. Thus, the drive sleeve 18" 22 "above the rotary drive sleeve 18" in the inside thereof so that relative rotation of the gear and the housing 2 "between the scale being provided with two doses given by the sound adapter nose portion 80 'and the splines 30 "engaging sound generated to confirm, along the spline housing 2" of the first portion 8 "of the inner surface extends.

限制螺母28”与被设定的剂量成比例地沿驱动套管18”爬升。 Limiting nut 28 "and is set in proportion to the dose along the drive sleeve 18" climb. 限制螺母28”的位置对应于药筒4”中剩余的药品的量,当驱动套管18”和壳体2”之间发生相对旋转时该限制螺母仅沿驱动套管18”的外部螺纹移动。 Limiting nut 28 "corresponds to the position of the cartridge 4" in the amount of drug remaining, when relative rotation occurs when the limit nut drive sleeve 18 "and the housing 2" between the drive sleeve 18 only along "the outer threads mobile .

一旦已设定所需的剂量(例如,如图19所示),则为了输送该剂量,用户按下剂量按钮56”以抵抗锁紧弹簧68”而推动该按钮56”。随着剂量按钮56”压下弹簧68”,在剂量按钮56”与剂量标度套管36”之间的离合器脱离接合。从剂量按钮56”施加在剂量标度套管36”上的轴向力使剂量标度套管36”在剂量标度套管36”和壳体2”之间的螺旋螺纹上旋入壳体2”内。锁紧弹簧68”变形,且该弹簧的支脚使驱动套管18”沿轴向向下移动。锁紧弹簧68”的插销部分76”接合在位于从驱动套管18”突出的外部凸缘26”上的通孔78”内,并保持凸缘26”的响声器突出部80”与花键30”之间的凹槽的接合,从而将该驱动套管锁定在壳体2”上,并防止在分配剂量期间驱动套管18”相对于壳体2”旋转。 Once the desired dose has been set (e.g., shown in Figure 19), then in order to transport the dose, the user presses the dose button 56 "to resist the locking spring 68" and push the button 56. "As the dose button 56 "pressure spring 68", the dose button 56 "and the dose dial sleeve 36" between the clutch disengaged from the dose button 56 "is applied to the dose dial sleeve 36" so that the axial force on the dose dial sleeve 36 "in the dose dial sleeve 36" and the housing 2 "is screwed into the screw threads between the housing 2". the locking spring 68 'is deformed, and the spring leg of the drive sleeve 18 "along axial movement downward. locking spring 68 "latch portion 76 'engages the drive sleeve located from 18" to highlight the external flange 26 "through holes on 78" inside, and keep the flange 26 "sound is outstanding the engagement portion 80 "and the splines 30" between the grooves, thereby locking the drive sleeve in the housing 2 ", the dose during dispensing and prevents the drive sleeve 18" relative to the housing 2 "rotation. 因此,可防止驱动套管18”旋转,并且该驱动套管沿轴向移入,从而使齿轮22”相对于固定的齿条6”旋转。齿轮22”连同该齿轮安装于其上的活塞杆32”沿齿条6”移动一段距离,该距离等于驱动套管18”沿轴向移动的距离的一半,从而生成2∶1的机械利益。这样带来的双重好处之一是对于活塞14”在药筒4”内的给定行程,即对于将被分配的给定量的药品,可使剂量标度套管36”上的显示更大,第二个好处是使分配该剂量所需的力减半。 Therefore, to prevent the driving sleeve 18 "is rotated, and the drive sleeve in the axial direction into, so that the gear 22 'relative to the fixed rack 6" rotary gear 22 ", together with the gear 32 mounted thereon on the piston rod "along the rack 6" is moved a distance which is equal to the drive sleeve 18 "moves axially half distance, thereby generating a mechanical advantage 2:1. One consequence of this is the dual benefit of the piston 14 'in 4 cartridge "within a given stroke, i.e., to be allocated for a given amount of drug, the dose dial sleeve 36 can" on the larger display, the second advantage is that the dispensing of the dose required to reduce the force and a half.

朝向给药装置的第一端驱动活塞杆32”穿过驱动套管18”,从而使药筒的活塞14”前进,并排出所需剂量的药品。活塞杆32”继续前进,直到驱动套管18”和剂量标度套管36”返回其初始位置(图20)。 Delivery device toward the first end of the drive rod 32 'through the drive sleeve 18 ", so that the cartridge piston 14" forward, and discharge the required dose of drugs. Piston rod 32 "continues to advance until the drive sleeve 18 "and dose dial sleeve 36" returns to its initial position (FIG. 20).

可见,在选择剂量时剂量选择装置和剂量排出装置延伸到壳体2”的第二端之外,并当排出选定的剂量时返回壳体2”内。 Be seen, the choice of the dose selecting means and the dose expelling dose means extends into the housing 2 "of the second end outside the housing when the discharge and return the selected dose 2".

需要时还可输送其它剂量。 Other doses may also be conveyed when required. 图21示出随后选择的剂量的示例。 Figure 21 shows an example of a subsequently selected dosage. 如上所述,限制螺母28”沿驱动套管18”的外部螺纹的位置对应于药筒4”中剩余的药品量,从而当螺母28”到达外部凸缘26”且不能进一步旋转时,这对应于药筒4”中没有剩余药品。 As described above, limiting nut 28 "along the drive sleeve 18" corresponds to the location of the external thread of the cartridge 4 "in the remaining amount of drug, so that when the nut 28" reaches the external flange 26 "and can not be further rotated, which corresponds to 4 "no remaining drug in the cartridge. 可见,如果使用者打算选择的药品的量大于药筒4”中剩余的量,则这不能实现,因为当螺母28”停止相对于驱动套管18”的旋转时,驱动套管18”和壳体2”将锁定在一起,从而防止驱动套管18”和从而剂量标度套管36”旋转。这样可防止设定的剂量大于药筒4”中剩余的药品量。 Visible, if the user intends to select the amount of drug in the cartridge 4 "in the remaining amount, then this can not be achieved, since when the nut 28" stops with respect to the drive sleeve 18 "when the rotation of the drive sleeve 18" and the shell Body 2 "will be locked together, thereby preventing the drive sleeve 18" and dose dial sleeve 36 so that "rotation. This prevents setting a dose larger than the cartridge 4" in the amount of drug remaining. 图22示出根据本发明的给药装置,其中已排出药筒4”中的全部药品。 Figure 22 shows a medication administering device according to the invention, which have been discharged 4 "of all the drug cartridge.

所示出的根据本发明的装置的实施例还包括最大剂量设定止动件。 Illustrated further includes a maximum dose setting stopper apparatus according to an embodiment of the present invention. 当剂量标度套管36”被完全用标度设定时,驱动套管18”上的外部凸缘26”与壳体2”中的内部凸缘46”相接合。应看到,如果使用者试图设定的剂量超过最大剂量,则这不能实现。当驱动套管18”停止相对于壳体2”旋转时,也防止剂量标度套管旋转。外部凸缘44”和内部凸缘86”之间的作用向使用者表明已用标度设定最大剂量。 When the dose dial sleeve 36 "when the scale is completely set, the drive sleeve 18" external flange 26 "and the housing 2" in the internal flange 46 "on the engagement should be seen, if used attempts to set a dose exceeding the maximum dosage, this can not be achieved. When the drive sleeve 18 "stops relative to the housing 2" is rotated, the dose dial sleeve is prevented from rotating. external flange 44 "and the internal flange 86 effect "between the show has been set to the user with a maximum dose of scale.

Referenced by
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CN102655899A *16 Dec 20105 Sep 2012赛诺菲-安万特德国有限公司Dose setting mechanism with maximum dose limiting element
CN102655899B *16 Dec 20107 Jan 2015赛诺菲-安万特德国有限公司Dose setting mechanism with maximum dose limiting element
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