CN1374876A - 剂量设定限制器 - Google Patents

剂量设定限制器 Download PDF

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CN1374876A
CN1374876A CN00812954A CN00812954A CN1374876A CN 1374876 A CN1374876 A CN 1374876A CN 00812954 A CN00812954 A CN 00812954A CN 00812954 A CN00812954 A CN 00812954A CN 1374876 A CN1374876 A CN 1374876A
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driver
track
dosage
dosage setting
dose
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CN1183975C (zh
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彼得·克里斯蒂安·克利特伽德
斯特芬·汉森
伯·拉德默
克洛斯·施密特·默勒
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Novo Nordisk AS
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Abstract

一种防止设定超过注射装置的针筒内残留液体量的剂量的限制机构。该注射装置是由剂量设定部件相对于驱动器并远离注射装置内固定的止动件旋转而设定剂量的类型。剂量设定部件与驱动器相接,从而不用旋转驱动器而可以在一个方向旋转剂量设定部件。通过将剂量设定部件旋回而注射剂量,该剂量设定部件在向后旋转过程中带着驱动器。驱动器旋转导致活塞杆在针筒内向前移动,射出在针筒内的某些液体。驱动器设有其长度与针筒内的液体总量相关的轨道,该轨道被与剂量设定部件连接的轨道随动件啮合,以跟踪剂量设定部件的旋转。每次设定和注射剂量时,轨道随动件再移动进入轨道。当轨道随动件达到轨道的末端时,剂量设定部件再不能旋转,不能设定大于针筒内残留液体的剂量。

Description

剂量设定限制器
本发明涉及一种注射装置，其中针筒的内容物以多次单独设定的剂量来注射。
这种设备具有剂量设定机构，通过该机构，在启动注射按钮时为随后的注射设定剂量。这可以通过沿着活塞杆将托架移动与所需剂量成比例的距离然后将托架移动返回它的初始位置而实现，从而托架携带着活塞杆，而不是沿着所述活塞杆移动。
从EP327910中知道这样一种注射装置，它通过将螺母沿着有螺纹的活塞杆向上拧离开壳体中的止动件而设定剂量。通过按压形成注射按钮的螺母的端部，由此使得螺母部件移回而再次与止动件邻接，来注射该设定的剂量。在螺母的后一次移动中，活塞杆由螺母携带，该螺母在注射中相对于该活塞杆不移动。
在剂量设定时，如果设有一个限制器而使得一个超出留在针筒中的药剂的剂量设定不可能，这是很方便的。在EP327910中，这是通过活塞杆的螺纹具有的长度使得当螺母拧在螺纹的端部时并且然后压回原位至它与止动件邻接位置时针筒恰好是空的来实现。通过设定剂量，螺母只能被拧至螺纹的端部，因此最后的剂量的大小就被限制为包括针筒内的剩余量。
注射按钮必须移动的距离与针筒中的活塞必须移动以注射设定剂量的距离相对应。特别是具有大横截面直径的大针筒，该距离能够是非常短的。为了获得注射按钮的较大移动，可以使用一种齿轮，从而注射按钮必须移动的距离与注射剂量成比例而不是与针筒中活塞移动的次数成比例。
EP608343中描述了这种齿轮传动的剂量设定和注射机构的实施例。在这种设备中，托架不直接与有螺纹的活塞杆共同操作，而是与注射设定剂量时能移动活塞杆的驱动元件共同操作。在这种设备中，驱动元件包括螺母部件，它被固定而抵抗在注射设备中的轴向位移。螺母部件的螺纹与活塞杆的外螺纹相配合，该活塞杆被固定以抵抗在注射设备中的旋转。通过设定剂量，托架旋转离开止动件，当注射按钮被启动之后，它再返回止动件。在它返回过程中，托架旋转驱动元件，该驱动元件将活塞杆进一步移动进入针筒以压该针筒的活塞，从而针筒内药剂的设定量被通过在所述针筒的远端处的注射针头而压出。因为在剂量设定过程中螺母部件相对于活塞杆不移动，因此不能设置如上所述的限制机构来限定所述剂量使其不会超过留在注射装置中的液体量。
本发明的一个目的是提供一种限制机构，它防止设定一个超过齿轮传动型注射设备的针筒内留有的液体量的剂量，其中剂量是通过相对于驱动器并远离注射装置中的固定止动件而旋转剂量设定部件来设定的，该剂量通过将剂量设定部件旋转回而注射，该剂量设定部件在这个旋转操作中携带着驱动元件与它在一起，以旋转该将活塞向前移动的驱动元件。
本发明的这种机构特征在于，该驱动元件设有轨道，其长度与针筒内总的药剂量相关，并且该轨道通过与剂量设定部件相耦合的轨道随动件而啮合，以跟随所述剂量设定部件的旋转。随着在剂量设定过程中剂量设定部件和驱动器彼此相对旋转。在剂量设定过程中，轨道随动件会根据设定剂量而在驱动器的轨道内前进至一个位置。因为在注射过程中，驱动器跟随剂量设定部件的旋转，因此当注射设定剂量时，剂量设定部件的销会保持它在驱动器的轨道内的位置。该轨道的长度被调整为使得销到达轨道的末端并且当设定对应于针筒内剩余液体量的剂量时使得设定剂量不能增加。
根据本发明，该驱动器可以是盘状的，并具有螺旋形轨道，该轨道被与剂量设定部件柔性连接的部件上的凸轮所啮合，从而当销跟随驱动器的轨道时，该销可以径向移动。
在本发明的另一个实施方案中，驱动器可以是圆筒状，并具有螺旋形轨道，该轨道被与驱动器圆筒状同心的剂量设定部件上的凸轮所啮合。
该轨道可以被设置为驱动器内的螺纹，并且轨道随动件可以是与剂量设定部件相耦合的螺母形部件，该轨道随动件设有与驱动器的螺纹相啮合的螺纹。当设定剂量时，该剂量设定部件被利用它的螺纹沿着驱动器的螺纹拧紧。设定剂量的限制是通过使螺纹具有适当的长度而实现的。
以下，参考附图更详细的解释本发明。
图1表示具有本发明的剂量限制器的注射装置的分解视图；
图2表示图1中的注射装置的剂量设定元件和驱动元件的放大视图；
图3表示注射装置的另一实施方案的剂量设定元件、驱动器和轨道随动件。
图1中的注射装置包括容纳针筒2的外壳1，内容物由活塞杆3从该针筒压出，所述活塞杆借助于齿轮4和5前进与经过剂量设定而设定的剂量相对应的距离而注射。剂量设定部件6设置有围绕着中心孔的齿轮7，驱动器9上的小齿轮8通过该孔伸出，如图2所示。剂量设定部件6通过操作元件10来操作，该操作元件10具有手指夹(finger grip)11、啮合剂量设定部件6的托架12以及在位于形成为外壳1的一部分的盖15上的标尺14上指示的箭头13。图1还显示了帽25，它可以盖上以保护可能安装在注射装置上的未显示的针头，并显示了注射按钮16，它滑动安装在外壳1内并具有一凹槽17，凹槽在设置了榫18的侧面之一上。
在组装的注射装置中，剂量设定部件6上的齿轮7啮合按钮元件16上的榫18，而驱动器9上的小齿轮8与齿轮5的大直径部分啮合，其小直径部分与另一齿轮4啮合，齿轮4还与活塞杆3上的榫19相啮合。
驱动器9设有棘爪26，它与外壳内未显示的齿形成单向连接，使得驱动器9只能沿活塞杆3前进进入针筒2的方向旋转。通过与驱动器9周边的锯齿状榫27啮合的剂量设定部件6上的锯齿状突起而设置棘轮，该棘轮的取向使得只有剂量设定部件6沿着驱动器9能移动的方向的旋转被从剂量设定部件6传递给驱动器9。通过剂量设定部件6沿着相反方向旋转，棘轮部件的齿会相互压制。
为了设定剂量，操作元件10的打捞工具11被抓紧，并且元件10被顺时针旋转直至标尺14上的箭头指在所需要的剂量上。如上所示，该旋转会使得剂量设定元件的棘轮部件以及驱动器彼此相互压制。如果剂量设定部件6在逆时针方向旋转以减少设定剂量，棘轮会导致旋转从剂量设定部件6传递给驱动器9，但是当该方向的扭矩被从操作元件经托架12传递给剂量设定部件6，该剂量设定部件变形，从而剂量设定部件6上的突起从它与驱动器9的齿27的啮合中脱出，不经旋转被传递给驱动器9，剂量设定部件6就可以逆时针旋转。
由于剂量设定部件6上的齿轮7与注射按钮16的榫18之间的啮合，当剂量被设定时该按钮会从外壳1的端部升起，而当剂量被减少时该按钮会降低。
当注射按钮16被压下以注射设定剂量，剂量设定部件6上的齿轮7与注射按钮16的榫18之间的啮合会使得剂量设定部件6逆时针方向旋转。因为扭矩没有由操作元件10传递给剂量设定部件6，剂量设定部件6和驱动器9之间连接的棘轮会被启动，并且驱动器9会在逆时针方向随剂量设定部件6旋转，并驱动活塞杆3进入针筒。
如图2所示，盘状驱动器9在其面对剂量设定部件6的侧面内具有螺旋状轨道20，该轨道被设置在臂22端部的凸轮21所啮合，臂22被弹性梁23紧固在剂量设定部件6上，从而臂22可以摆动以使得凸轮21沿驱动器9的径向移动。当在剂量设定过程中剂量设定部件6相对于驱动器9旋转时，凸轮沿着轨道20移动，而在注射过程中，由于剂量设定部件6和驱动器9的伴随转动，凸轮保持在它在剂量设定过程中在轨道20内的位置。这样凸轮在轨道中的位置反映了给药的总量。当凸轮21邻接轨道20的端壁24时，设定的剂量不能增加，并且通过将轨道的长度调整至针筒内药的总量，确保了不能设定大于在针筒内残留的药量的剂量。
图3表示剂量设定限制器的另一实施方案的围绕驱动器31的剂量设定部件30。剂量设定部件30是圆筒状，在其外壁上设有螺旋状轨道29，该轨道被设计为与外壳内未显示的螺旋内脊一同操作，从而当旋转以设定剂量时剂量设定部件30向外拧，当旋转以减小过大的设定剂量时，该剂量设定部件30在所述外壳内向内拧。在剂量设定旋转中，剂量设定部件30相对于它围绕的驱动器31自由旋转。在剂量设定部件30和驱动器31之间，连接有螺母部件32，当其相对于驱动器31旋转时它能够被沿着该驱动器向上拧，该驱动器在其外表面上设有螺旋轨道33。螺母部件32在其外壁沿轴向设有凹槽34，该凹槽被在剂量设定部件30的内侧上沿着轴向的脊35啮合。
在剂量设定过程中，由于脊35和凹槽34之间的啮合，螺母部件32随剂量设定部件30相对于驱动器31旋转，从而螺母部件32在该驱动器上的位置依赖于剂量设定。当该剂量通过按压置于剂量设定部件30的端部36内的未显示注射按钮而被注射时，该按钮将驱动器31端部的凸缘37压成与剂量设定部件30所述端部36的按钮处的连接齿38相连接。在其下部不可见的侧面，凸缘37设有与剂量设定部件30的连接齿38相对应的连接齿，当剂量设定部件30由于剂量设定部件30内的轨道29与外壳内的脊之间的啮合而被强迫以在它被压进所述外壳内时相对于外壳旋转时，该旋转被传递给驱动器31，该驱动器31由于啮合连接齿而被强迫随着剂量设定部件旋转，在该旋转过程中，螺母部件32会保持在它在驱动器31上的位置。这样螺母部件32在驱动器31上的位置会始终指示设定和注射剂量的总和。当驱动器31内的螺旋轨道33的长度被调整至针筒内的药剂总量时，螺母部件32会到达轨道33的端部，并停止设定比针筒内残留药量大的剂量。

Claims (4)

1.一种限制机构，它防止设定超过注射装置的针筒内剩余液体量的剂量，其中通过相对于驱动器并远离注射装置内的固定止动件而旋转剂量设定部件来设定剂量，该剂量通过将该驱动器旋转返回而注射，在这种旋转过程中，该剂量设定部件带着驱动器一起旋转以旋转该将活塞杆向前移动的驱动器，其特征在于驱动器设有其长度与针筒内的药剂总量相关的轨道，该轨道被与剂量设定部件连接的轨道随动件啮合，以跟随该剂量设定部件的旋转。
2.如权利要求1所述的限制机构，其特征在于，驱动器为圆盘形，具有螺旋状轨道，该轨道被与剂量设定元件柔性连接的凸轮啮合，从而所述凸轮能够在它跟随驱动元件的轨道时径向移动。
3.如权利要求1的限制机构，其特征在于驱动器是圆筒状，具有螺旋状轨道，该轨道被与剂量设定部件连接的凸轮啮合，剂量设定部件是与驱动器同心的圆筒状。
4.如权利要求3的限制机构，其特征在于轨道设置成驱动器内的螺纹，轨道随动件是与剂量设定部件连接的螺母状部件并设有与驱动器的螺纹相啮合的螺纹。
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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101227943B (zh) * 2005-07-27 2010-12-15 诺沃-诺迪斯克有限公司 用于限制对应于剩余药品量的剂量设定的注射设备的剂量机构
CN104470558A (zh) * 2012-04-10 2015-03-25 卡贝欧洲有限公司 注入装置
CN104955505A (zh) * 2013-02-01 2015-09-30 诺和诺德股份有限公司 非轴向工作内含物排空机构和包括该非轴向工作内含物排空机构的注射装置
CN105102031A (zh) * 2013-04-10 2015-11-25 赛诺菲 用于药物输送装置的驱动机构
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CN105682709A (zh) * 2013-09-03 2016-06-15 赛诺菲 用于药物输送装置的驱动组件和包括驱动组件的药物输送装置
CN107106773A (zh) * 2014-12-08 2017-08-29 赛诺菲 驱动机构和具有该驱动机构的药物输送装置
US10117996B2 (en) 2012-12-21 2018-11-06 Novo Nordisk A/S State changing appliance for a drug delivery device
US10406292B2 (en) 2009-06-01 2019-09-10 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
CN111295213A (zh) * 2017-11-07 2020-06-16 赛诺菲-安万特德国有限公司 具有剂量限制器的注射装置
CN112584884A (zh) * 2018-08-15 2021-03-30 赛诺菲 用于附接至注射装置的数据收集设备
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Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2305634C (en) 1998-01-30 2006-01-03 Novo Nordisk A/S An injection syringe
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
IL156245A0 (en) * 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
JP2005532129A (ja) 2002-07-10 2005-10-27 ノボ・ノルデイスク・エー／エス 投与量設定リミッタを備える注入器
EP1545656A1 (en) * 2002-07-24 2005-06-29 M 2 Medical A/S An infusion pump system, an infusion pump unit and an infusion pump
DE10239784B4 (de) * 2002-08-29 2004-12-30 Tecpharma Licensing Ag Injektions-, Infusions- oder Inhalationsvorrichtung mit Dosisanzeigevorrichtung
DE10240166A1 (de) 2002-08-30 2004-03-18 Disetronic Licensing Ag Vorrichtung zur kontrollierten Ausschüttung einer injizierbaren Flüssigkeit
CN1726059A (zh) 2002-11-05 2006-01-25 M2医药有限公司 一种一次性可穿戴的胰岛素分配装置,这种装置和一个程序控制器的组合以及控制这种装置工作的方法
DE60319142T2 (de) 2002-12-23 2009-02-05 M2 Medical A/S Medizinische Vorrichtung zur Abgabe von Insulin
CN1732027A (zh) * 2002-12-23 2006-02-08 M2医药有限公司 柔性活塞杆
DE602004031927D1 (de) 2003-02-04 2011-05-05 Novo Nordisk As Injektionsvorrichtung mit drehbarer dosiseinstellungsvorrichtung
US9205197B2 (en) 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0308267D0 (en) * 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
WO2005021072A1 (en) 2003-09-03 2005-03-10 Novo Nordisk A/S Threaded rod and nut assembly
US7753879B2 (en) * 2004-01-29 2010-07-13 M2 Group Holdings, Inc. Disposable medicine dispensing device
DK1732628T3 (da) 2004-03-30 2011-10-24 Lilly Co Eli Medicindoseringsapparat med gearsæt med åbning til et drivelement
JP4874233B2 (ja) 2004-03-30 2012-02-15 イーライ リリー アンド カンパニー 最終用量の投与によって可能になるバネ駆動固定の特徴を持つ薬剤投与器具
ATE444090T1 (de) 2004-10-21 2009-10-15 Novo Nordisk As Wählmechanismus für einen drehstift
DE602005017182D1 (de) 2004-10-21 2009-11-26 Novo Nordisk As Injektionsvorrichtung mit torsionsfeder und drehbarer anzeige
DE602005026595D1 (de) 2004-12-01 2011-04-07 Novo Nordisk As Injektionsvorrichtung
DE102004063649B4 (de) * 2004-12-31 2007-01-18 Tecpharma Licensing Ag Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit andockbarer Dosisanzeige
WO2006086983A1 (en) * 2005-02-17 2006-08-24 Novo Nordisk A/S A dose setting element for an injection device and having a dose setting limiting mechanism
US9101722B2 (en) 2005-02-28 2015-08-11 Novo Nordisk A/S Dose setting mechanism for an injection device capable of presetting a maximum dose
EP1855744A1 (en) * 2005-02-28 2007-11-21 Novo Nordisk A/S A dose setting mechanism for an injection device
EP1877115A1 (en) 2005-04-06 2008-01-16 M 2 Medical A/S An actuator
EP1877121B1 (en) 2005-04-24 2015-09-23 Novo Nordisk A/S Injection device
DE102005023854B4 (de) † 2005-05-24 2020-12-17 Tecpharma Licensing Ag Dosiervorrichtung für eine Injektionsvorrichtung
EP1907031A2 (en) * 2005-05-31 2008-04-09 Novo Nordisk A/S Injection device with visual end-of-content indication
DE602006010396D1 (de) 2005-07-27 2009-12-24 Novo Nordisk As Spritzenvorrichtung mit einem dosisbegrenzenden mechanismus und einem zusätzlichen sicherheitsmechanismus
US8551046B2 (en) 2006-09-18 2013-10-08 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8409142B2 (en) 2005-09-26 2013-04-02 Asante Solutions, Inc. Operating an infusion pump system
WO2007038060A2 (en) 2005-09-26 2007-04-05 M2 Medical A/S Modular infusion pump having two different energy sources
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8057436B2 (en) 2005-09-26 2011-11-15 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US7534226B2 (en) 2005-09-26 2009-05-19 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
EP3064236B1 (en) 2005-11-08 2020-02-05 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US8475408B2 (en) 2005-11-08 2013-07-02 Asante Solutions, Inc. Infusion pump system
JP5183499B2 (ja) * 2006-03-10 2013-04-17 ノボ・ノルデイスク・エー／エス 注射装置
JP5062768B2 (ja) 2006-03-10 2012-10-31 ノボ・ノルデイスク・エー／エス 注射装置および該装置のカートリッジを交換する方法
EP2007451B1 (en) * 2006-03-21 2018-11-07 SHL Group AB Dose information device
US7954624B2 (en) * 2006-05-16 2011-06-07 Rorze Corporation Shuttle type conveying device, microplate feeding and collecting device, pickup device for microplate, cassette for microplate, and shelf for containing microplate
DE602007004972D1 (de) 2006-05-16 2010-04-08 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
AU2007253481B2 (en) 2006-05-18 2013-01-17 Novo Nordisk A/S An injection device with mode locking means
EP3738626B1 (de) 2006-09-15 2022-08-10 Ypsomed AG Injektionsgerät mit verbessertem förderelement
PL2109474T5 (pl) 2007-02-05 2019-07-31 Novo Nordisk A/S Przycisk iniekcyjny
JP5230722B2 (ja) 2007-03-23 2013-07-10 ノボ・ノルデイスク・エー／エス ロックナットを備えた注射装置
US7981102B2 (en) 2007-05-21 2011-07-19 Asante Solutions, Inc. Removable controller for an infusion pump
US7794426B2 (en) 2007-05-21 2010-09-14 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
US7833196B2 (en) 2007-05-21 2010-11-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US7892199B2 (en) 2007-05-21 2011-02-22 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US7828528B2 (en) * 2007-09-06 2010-11-09 Asante Solutions, Inc. Occlusion sensing system for infusion pumps
US7935076B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US7879026B2 (en) 2007-09-07 2011-02-01 Asante Solutions, Inc. Controlled adjustment of medicine dispensation from an infusion pump device
US7935105B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Data storage for an infusion pump system
US8287514B2 (en) 2007-09-07 2012-10-16 Asante Solutions, Inc. Power management techniques for an infusion pump system
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
EP2274029B1 (en) 2008-05-02 2011-11-02 Sanofi-Aventis Deutschland GmbH Medication delivery device
US8647309B2 (en) * 2008-05-02 2014-02-11 Sanofi-Aventis Deutschland Gmbh Medication delivery device
US8267900B2 (en) 2008-05-02 2012-09-18 Sanofi-Aventis Deutschland Gmbh Medication delivery device
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
RU2506957C2 (ru) * 2008-10-24 2014-02-20 Ново Нордиск А/С Механизм уменьшения установленной дозы для взводимого шприца-ручки
EP2370135B1 (en) * 2008-12-09 2020-02-05 Becton, Dickinson and Company Lever and gear force multiplier medication delivery system for high pressure injection system
ES2927372T3 (es) 2008-12-09 2022-11-04 Becton Dickinson Co Mecanismo de bombeo de suministro de carrera múltiple para un dispositivo de administración de medicamentos para inyecciones de alta presión
EP2196232A1 (en) 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Drive mechanism for a medication delivery device and medication delivery device
EP2196233A1 (en) 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Resettable drive mechanism for a medication delivery device and medication delivery device
US10034982B2 (en) 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
US8585656B2 (en) 2009-06-01 2013-11-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9199040B2 (en) * 2009-06-01 2015-12-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device last dose lock-out mechanism
US9463283B2 (en) 2009-06-01 2016-10-11 Sanofi-Aventis Deutschland Gmbh Dosing mechanism for a drug deliver device
US8974423B2 (en) 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US9950116B2 (en) 2009-06-01 2018-04-24 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9623187B2 (en) 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US9457150B2 (en) 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
US9125994B2 (en) 2009-06-01 2015-09-08 Sanofi—Aventis Deutschland GmbH Drug delivery device with dose dial sleeve rotational stop
US8672896B2 (en) 2009-06-01 2014-03-18 Sanofi-Aventis Deutschland Gmbh Inner housing for a drug delivery device
US9238106B2 (en) 2009-06-01 2016-01-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9345840B2 (en) 2009-06-01 2016-05-24 Sanofi-Aventis Deutschland Gmbh Drug delivery dose setting mechanism with variable maximum dose
US8728043B2 (en) 2009-06-01 2014-05-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US9108007B2 (en) 2009-06-01 2015-08-18 Sanofi-Aventis Deutschland Gmbh Spindle and bearing combination and drug delivery device
AR076722A1 (es) 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Conjunto para un dispositivo para l a entrega de farmacos y dispositivo para la entrega de farmacos
EP3284494A1 (en) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Portable infusion pump system
DE102009043803B4 (de) * 2009-09-30 2018-01-18 Tecpharma Licensing Ag Injektionsvorrichtung mit einer Ausschüttstoppfunktion
GB0918145D0 (en) 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
WO2011060785A1 (en) 2009-11-20 2011-05-26 Moeller Claus Schmidt Injection device without a gearing
WO2011068531A1 (en) 2009-12-01 2011-06-09 Becton, Dickinson And Company Injection pen with dial back and last dose control
TWI415644B (zh) * 2009-12-14 2013-11-21 Shl Group Ab 藥物輸送裝置
US8926568B2 (en) * 2010-05-20 2015-01-06 Shl Group Ab Medicament delivery device comprising a manual activation member with improved gripping and activation abilities
USD669165S1 (en) 2010-05-27 2012-10-16 Asante Solutions, Inc. Infusion pump
US8430848B1 (en) 2010-08-13 2013-04-30 Jonathan Dawrant Reservoir and administration device with ratcheting mechanism
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
USD729930S1 (en) 2011-03-08 2015-05-19 Novo Nordisk A/S Injection device
US8454581B2 (en) 2011-03-16 2013-06-04 Asante Solutions, Inc. Infusion pump systems and methods
EP4035712A1 (en) 2011-03-16 2022-08-03 Becton, Dickinson and Company Multiple use disposable injection pen
US11577029B2 (en) 2012-03-15 2023-02-14 Becton, Dickinson And Company Multiple use disposable injection pen
US9993529B2 (en) 2011-06-17 2018-06-12 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
US20130085349A1 (en) 2011-06-21 2013-04-04 Yofimeter, Llc Analyte testing devices
US8333716B1 (en) 2011-06-21 2012-12-18 Yofimeter, Llc Methods for using an analyte testing device
US8585657B2 (en) 2011-06-21 2013-11-19 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8808230B2 (en) 2011-09-07 2014-08-19 Asante Solutions, Inc. Occlusion detection for an infusion pump system
DE102011082463A1 (de) * 2011-09-09 2013-03-14 Tecpharma Licensing Ag Dose Memory Pen mit Blockierung
USD734450S1 (en) 2011-11-01 2015-07-14 Novo Nordisk A/S Injection device
JP6069351B2 (ja) 2011-12-29 2017-02-01 ノボ・ノルデイスク・エー／エス ダイアルアップ／ダイアルダウン投与機構を有するねじりバネ式ねじ巻き自動注射器
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
WO2013127876A1 (de) 2012-02-29 2013-09-06 Tecpharma Licensing Ag Injektionsvorrichtung mit verbessertem kolbenstangenantrieb
US9295782B2 (en) 2012-03-15 2016-03-29 Becton, Dickinson And Company Multiple use disposable injection pen
EP2644218B2 (de) 2012-03-30 2022-11-02 Tecpharma Licensing AG Injektionsvorrichtung mit Dosisanzeige und Federantrieb
EP2644217A1 (de) 2012-03-30 2013-10-02 TecPharma Licensing AG Injektionsvorrichtung mit Dosisanzeige und Federantrieb
WO2013144020A1 (de) 2012-03-30 2013-10-03 Tecpharma Licensing Ag Injektionsvorrichtung mit einem relativ zu einem gehäuse verschiebbaren dosisanzeigeelement
WO2013149769A1 (de) 2012-04-05 2013-10-10 Tecpharma Licensing Ag Injektionsvorrichtung mit verbessertem kolbenstangenantrieb
CH706567A2 (de) 2012-05-16 2013-11-29 Tecpharma Licensing Ag Verbesserte Vorrichtung zum Einstellen einer Dosis mit einem Begrenzungsmechanismus für ein Gerät zur Verabreichung eines Produkts.
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
EP2869874B1 (en) * 2012-07-06 2018-12-12 SHL Medical AG Medicament delivery device
US8454557B1 (en) 2012-07-19 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US8454562B1 (en) 2012-07-20 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
EP2692376B1 (de) 2012-08-01 2019-04-03 TecPharma Licensing AG Injektionsvorrichtung mit einer helix- bzw. wendelförmigen Dosisskala
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US20140276536A1 (en) 2013-03-14 2014-09-18 Asante Solutions, Inc. Infusion Pump System and Methods
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9180243B2 (en) 2013-03-15 2015-11-10 Tandem Diabetes Care, Inc. Detection of infusion pump conditions
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
DK3021913T3 (en) 2013-07-17 2018-01-08 Sanofi Sa A drug
WO2015007823A1 (en) 2013-07-17 2015-01-22 Sanofi Drug delivery device
WO2015007811A1 (en) * 2013-07-17 2015-01-22 Sanofi Drive mechanism
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
EP2829292B1 (de) 2013-07-22 2017-11-01 TecPharma Licensing AG Antriebs- und Dosiervorrichtung mit einem Begrenzungselement zur Verhinderung der Einstellung einer höheren Dosis als verfügbar
US10220153B2 (en) 2013-09-03 2019-03-05 Sanofi Pen type drug injection device with dose limiting nut to prevent setting of a dose higher than the amount of drug remaining
EP3043840B1 (de) 2013-09-09 2017-08-16 Tecpharma Licensing AG Injektionsvorrichtung mit einem betätigungsknopf, dessen betätigung eine drehbewegung bewirkt
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3263159B1 (de) 2013-12-05 2020-07-01 Tecpharma Licensing AG Injektionsvorrichtung it einem dosierglied und einer vorgespannten ausschüttfeder
EP2918298B1 (de) 2014-03-13 2021-05-19 Ypsomed AG Verbesserter Dosiermechanismus für eine Injektionsvorrichtung zum Verabreichen eines Produkts
US10004845B2 (en) 2014-04-18 2018-06-26 Becton, Dickinson And Company Split piston metering pump
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US10971260B2 (en) 2014-09-14 2021-04-06 Becton, Dickinson And Company System and method for capturing dose information
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
US11007324B2 (en) 2014-12-08 2021-05-18 Sanofi Drug delivery device comprising a prism
CA3009221A1 (en) 2014-12-23 2016-06-30 Automed Pty Ltd Delivery apparatus, system and associated methods
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
CN107787237B (zh) 2015-07-01 2021-02-02 诺和诺德股份有限公司 药物输送装置
CN107708773B (zh) 2015-07-01 2020-10-30 诺和诺德股份有限公司 药物输送装置和用于组装药物输送装置的方法
WO2017001693A1 (en) 2015-07-01 2017-01-05 Novo Nordisk A/S A piston washer for a drug delivery device and drug delivery device incorporating such piston washer
EP3175875A1 (en) 2015-12-02 2017-06-07 Novo Nordisk A/S Method for assembling a drug delivery device and drug delivery device formed by the method
AU2016385454B2 (en) 2016-01-05 2021-12-16 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
US10449294B1 (en) 2016-01-05 2019-10-22 Bigfoot Biomedical, Inc. Operating an infusion pump system
WO2017134131A1 (en) 2016-02-02 2017-08-10 Novo Nordisk A/S A hypocycloid end-of-content mechanism
EP3202443A1 (en) 2016-02-02 2017-08-09 Novo Nordisk A/S Piston washer for a drug delivery device, method of preparing such piston washer and method of assembly of a drug delivery device
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly
EP3481468B1 (en) 2016-07-08 2020-05-13 Novo Nordisk A/S Drug delivery device comprising an adjustment member
GB201615455D0 (en) 2016-09-12 2016-10-26 Norton Healthcare Ltd Last dose protection
CN109789264B (zh) 2016-09-27 2021-06-22 比格福特生物医药公司 药物注射和疾病管理系统、设备和方法
JP6935497B2 (ja) 2016-12-01 2021-09-15 ノボ・ノルデイスク・エー／エス クラッチ特徴を有する薬剤送達装置
USD836769S1 (en) 2016-12-12 2018-12-25 Bigfoot Biomedical, Inc. Insulin delivery controller
CN109922716A (zh) 2016-12-12 2019-06-21 比格福特生物医药公司 药物输送设备的警报和警惕以及相关的系统和方法
EP3348298A1 (en) 2017-01-16 2018-07-18 Novo Nordisk A/S Drug delivery device with rotationally geared piston rod driver
JP7007385B2 (ja) 2017-01-25 2022-01-24 ノボ・ノルデイスク・エー／エス 洗浄チャンバーを備えた予め充填された注射装置
JP7389650B2 (ja) 2017-04-07 2023-11-30 ノボ・ノルデイスク・エー／エス 内容物終了機構
USD839294S1 (en) 2017-06-16 2019-01-29 Bigfoot Biomedical, Inc. Display screen with graphical user interface for closed-loop medication delivery
US11389088B2 (en) 2017-07-13 2022-07-19 Bigfoot Biomedical, Inc. Multi-scale display of blood glucose information
US10688247B2 (en) * 2017-07-13 2020-06-23 Haselmeier Ag Injection device with flexible dose selection
CN111050750A (zh) 2017-08-24 2020-04-21 诺沃挪第克公司 Glp-1组合物及其用途
WO2019072826A1 (en) 2017-10-10 2019-04-18 Novo Nordisk A/S PRE-FILLED DRUG DELIVERY DEVICE WITH REDUCED AIR INTERVAL
FR3072297B1 (fr) * 2017-10-17 2023-05-12 Edix Sa Dispositif d'injection manuelle
WO2019180214A1 (en) 2018-03-23 2019-09-26 Novo Nordisk A/S Drug delivery device with dose counting mechanism
EP3603703A1 (en) 2018-07-30 2020-02-05 Tecpharma Licensing AG Alternative device for adjusting a dosage with a limiting mechanism for a device for administering a product
CN108888843B (zh) * 2018-08-10 2023-06-27 中国人民解放军总医院 用于人体空腔伤口的粉末止血剂推进器
EP3622987A1 (en) 2018-09-11 2020-03-18 Tecpharma Licensing AG A method for assembly of an injection or infusion device
RU2695625C1 (ru) 2019-02-18 2019-07-24 Общество с ограниченной ответственностью «НЭКСТ БИО» Инъекционное устройство
GB2582565B (en) * 2019-03-25 2021-05-05 Shaily Eng Plastics Ltd Fixed dose injector pens
USD926973S1 (en) 2019-09-05 2021-08-03 Novo Nordisk A/S Injection device
EP4106727A1 (en) 2020-02-18 2022-12-28 Novo Nordisk A/S Pharmaceutical formulations
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52621B1 (en) 1981-02-12 1988-01-06 Turner Robert Charles Dose metering plunger devices for use with syringes
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
DE3204178C2 (de) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipettiervorrichtung
DE3468173D1 (en) 1983-09-07 1988-02-04 Disetronic Ag Portable infusion apparatus
FR2583291A1 (fr) 1985-06-14 1986-12-19 Hazon Bernard Dispositif d'avancement pas a pas du piston de seringues par double vis coaxiale avec controle du debit d'injection. application aux injections medicamenteuses intra-dermiques repetitives
DE3670768D1 (de) 1985-11-08 1990-06-07 Disetronic Ag Injektionsgeraet.
DE3609555A1 (de) 1986-03-21 1987-09-24 Josef Porner Blutentnahmespritze
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
CH675078A5 (zh) 1988-01-22 1990-08-31 Nosta Ag
DK166948B1 (da) 1988-02-10 1993-08-09 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glastubule
US4973318A (en) * 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
DE69203472T2 (de) 1991-02-07 1996-01-04 Terumo Corp Dosiereinrichtung für Injektor.
DE4112259A1 (de) 1991-04-15 1992-10-22 Medico Dev Investment Co Injektionsgeraet
DK68991D0 (da) 1991-04-17 1991-04-17 Novo Nordisk As Manifold
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
ES2074771T3 (es) 1991-07-24 1995-09-16 Medico Dev Investment Co Inyector.
DK175491D0 (da) * 1991-10-18 1991-10-18 Novo Nordisk As Apparat
DK194291D0 (da) 1991-11-29 1991-11-29 Novo Nordisk As Sproejte til automatisk injektion.
US5611783A (en) 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
FR2686460B1 (fr) * 1992-01-20 1994-03-11 Labinal Precision Mecanique Organe de contact electrique femelle.
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
CH682806A5 (de) 1992-02-21 1993-11-30 Medimpex Ets Injektionsgerät.
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
EP0649316B2 (en) 1992-10-15 2013-08-28 The General Hospital Corporation An infusion pump with an electronically loadable drug library
US5545147A (en) * 1992-10-20 1996-08-13 Eli Lilly And Company Anti-backup improvement for hypodermic syringes
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
SE9301494D0 (sv) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for dosing liquid preparation
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
AU1595395A (en) 1994-06-15 1996-01-05 Interventional Research Technologies, Inc. Locking device for syringe or like instrument
US5827232A (en) * 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
CA2186869A1 (en) 1994-08-24 1996-02-29 Hideto Yamagata Injection apparatus
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) * 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
JP3712130B2 (ja) 1994-09-20 2005-11-02 ノボザイムス アクティーゼルスカブ 凝固を引き起こさずにその中の微生物を殺すための水性タンパク質溶液の処理方法
ZA958073B (en) 1994-09-28 1996-04-23 Anthony William Manicom Method of and apparatus for administering a drug to a patient
AU696439B2 (en) 1995-03-07 1998-09-10 Eli Lilly And Company Recyclable medication dispensing device
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
CN1138575C (zh) 1996-02-23 2004-02-18 诺沃挪第克公司 具有参数的电子表示的注射器
UA35653C2 (uk) 1996-03-12 2001-04-16 Ново Нордіск А/С Пристрій для ін'єкцій
EP0828527B1 (de) 1996-04-02 2002-07-31 Disetronic Licensing AG Injektionsgerät
AU724937B2 (en) 1996-04-24 2000-10-05 Novo Nordisk A/S Injection needle
JPH09307922A (ja) * 1996-05-17 1997-11-28 Sony Corp 色信号処理回路
CA2258491A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Automatic needle insertion mechanism
WO1998001173A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Flexible piston rod
CA2258308A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Dose setting device
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5947934A (en) * 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
DK0927057T3 (da) * 1996-09-13 2003-09-01 Novo Nordisk As Dosisvisningsorgan til en injektionssprøjte
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
JP2001501504A (ja) 1996-09-20 2001-02-06 ノボ ノルディスク アクティーゼルスカブ 作動シリンダ
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
JP2001511033A (ja) 1997-02-04 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 液状薬剤懸濁液の投与装置
DE29703820U1 (de) 1997-03-03 1998-07-02 Medico Dev Investment Co Injektionsgerät
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6277097B1 (en) 1997-03-25 2001-08-21 Novo Nordisk A/S Injection system
RU2111019C1 (ru) 1997-05-22 1998-05-20 Сергей Александрович Хворостов Универсальный инъектор
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
JP3503129B2 (ja) * 1997-06-30 2004-03-02 荒川化学工業株式会社 カラーフィルタ層用剥離剤およびカラーフィルタ用ガラス基板の再生方法
AU7331598A (en) 1997-07-11 1999-02-08 Novo Nordisk A/S An apparatus for the registration of the setting of a medical device
AU8333398A (en) 1997-07-14 1999-02-10 Novo Nordisk A/S Injection member
AU8333298A (en) 1997-07-14 1999-02-10 Novo Nordisk A/S Cylinder ampoule
DE19730999C1 (de) 1997-07-18 1998-12-10 Disetronic Licensing Ag Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
FR2767479B1 (fr) 1997-08-22 1999-10-22 Aguettant Lab Dispositif d'injection de medicament
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
CA2305634C (en) * 1998-01-30 2006-01-03 Novo Nordisk A/S An injection syringe
DE69931354T2 (de) 1998-02-13 2007-02-01 Bioniche Life Sciences Inc., Belleville Vorrichtung zum verabreichen eines medikamentes
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
PL345336A1 (en) 1998-07-08 2001-12-17 Novo Nordisk As A medical delivery device and a cartridge assembly for use in the same
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
ATE386563T1 (de) 2000-07-14 2008-03-15 Novo Nordisk As Flüssigkeitsabgabevorrichtung und verfahren zum vermindern des tröpfelns
AU2001289589A1 (en) 2000-09-22 2002-04-02 Novo-Nordisk A/S A medication delivery device
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
WO2002064196A1 (en) 2001-02-14 2002-08-22 Novo Nordisk A/S Electronically controlled injection or infusion device
ATE513570T1 (de) 2001-05-16 2011-07-15 Lilly Co Eli Spritzvorrichtung mit antriebseinrichtung, welche rückstellung vereinfacht
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
DE10163326A1 (de) 2001-07-30 2003-02-27 Disetronic Licensing Ag Verabreichungsgerät mit Dosiervorrichtung
AU2003209475A1 (en) 2002-03-07 2003-09-16 Vectura Limited Fast melt multiparticulate formulations for oral delivery
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
JP2005532129A (ja) 2002-07-10 2005-10-27 ノボ・ノルデイスク・エー／エス 投与量設定リミッタを備える注入器
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
WO2004020026A1 (en) 2002-08-29 2004-03-11 Novo Nordisk A/S Frontloaded injection device
US20050019400A1 (en) 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device

Cited By (20)

* Cited by examiner, † Cited by third party
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US10406292B2 (en) 2009-06-01 2019-09-10 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
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US10117996B2 (en) 2012-12-21 2018-11-06 Novo Nordisk A/S State changing appliance for a drug delivery device
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CN104955505A (zh) * 2013-02-01 2015-09-30 诺和诺德股份有限公司 非轴向工作内含物排空机构和包括该非轴向工作内含物排空机构的注射装置
CN105102031A (zh) * 2013-04-10 2015-11-25 赛诺菲 用于药物输送装置的驱动机构
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US10478562B2 (en) 2013-04-10 2019-11-19 Sanofi Drive mechanism of a drug delivery device
CN105682709A (zh) * 2013-09-03 2016-06-15 赛诺菲 用于药物输送装置的驱动组件和包括驱动组件的药物输送装置
CN107106773B (zh) * 2014-12-08 2020-10-30 赛诺菲 驱动机构和具有该驱动机构的药物输送装置
CN107106773A (zh) * 2014-12-08 2017-08-29 赛诺菲 驱动机构和具有该驱动机构的药物输送装置
CN111295213A (zh) * 2017-11-07 2020-06-16 赛诺菲-安万特德国有限公司 具有剂量限制器的注射装置
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