CN1304070C - Device for releasing medication for alimentary tract at fixed point - Google Patents
Device for releasing medication for alimentary tract at fixed point Download PDFInfo
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- CN1304070C CN1304070C CNB2004100408093A CN200410040809A CN1304070C CN 1304070 C CN1304070 C CN 1304070C CN B2004100408093 A CNB2004100408093 A CN B2004100408093A CN 200410040809 A CN200410040809 A CN 200410040809A CN 1304070 C CN1304070 C CN 1304070C
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- medicine
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- remote control
- release passage
- control module
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a device for releasing medicines towards the alimentary tract at definite time, particularly to a device for releasing a pill type medicine in definite time. The device comprises an out-of-body remote control mechanism and an electronic capsule which can be swallowed, wherein the electronic capsule comprises an outer shell, a battery, a remote control module, a compression spring, a piston, a medicine storage barn, a medicine release passage mechanism and a positioning mark source. The medicine storage barn is formed from a cavity among the piston, the inner wall of the outer shell, and the medicine release passage mechanism; the remote control module comprises a miniature heating element; the piston is fixed at one end in the outer shell of the electronic capsule by a polymer line with a low melting point; the polymer line is in contact with the miniature heating element. After the remote control module receives a remote control signal transmitted by the out-of-body remote control mechanism, a circuit is switched on; the temperature of the miniature heating element rapidly rises under the action of a power supply; the polymer line is burn out. The piston moves towards the other end of the electronic capsule under the driving of the compression spring; the medicine release passage mechanism is opened under the action of pressure generated by the movement of the piston; the medicine in the medicine storage barn is released by the medicine release passage mechanism. The present invention has the advantages of simple structure and high reliability, and is mainly used for releasing substances, such as medicines, foodstuffs, marks, etc., towards the alimentary tract of animals or human bodies.
Description
Technical field:
The present invention relates to a kind of digestive tract medicine fixed point releasing device, specially refer to a kind of digestive tract medicine of swallowing fixed point releasing device of pill formula, be used for digestive tract h substance, as medicine, food, label etc. at animal or human's body.
Background technology:
A kind of device at digestive tract assigned address h substance has been proposed in U.S. Pat 4425117, this device is divided into two cells, a movable mechanism that can move under the pressure effect of compression spring is arranged in first Room, a pin is arranged in the movable mechanism end; Second cell be around foraminate medicine holding bin, drug pack is put into medicine holding bin in tiny balloons; Being equipped with a fixed dam in the interposition of this device separates two cells.When this device arrives the digestive tract assigned address, the external world sends electromagnetic wave signal, be arranged in the coil and the oscillating circuit induction outer signals of this device case and produce faradic current, release movement is triggered by institute's faradic current, movable mechanism travels forward under the spring pressure effect, and at certain position, the broken baffle plate of acupuncture also punctures the balloon that medicine is housed, under the contraction of balloon, drug release.There is following shortcoming in this device, and at first, the release of medicine depends on the aperture that balloon is broken by acupuncture, if balloon interior pressure is big inadequately, then drug releasing rate is slower; Secondly, the passage that medicine discharges in install is the aperture on the shell circumferential wall, medicine discharges the leakage that depends on aperture from medicine holding bin, and these apertures may be blocked by the material in the digestive tract, do not have suitable impressed pressure, and medicine might can't go out by small hole leaking, when particularly the outer wall of medicine holding bin closely contacts with digestive tract, medicinal liquid may can only discharge in the storage warehouse, discharges not thoroughly, and reliability is lower; In addition, this technical scheme only is fit to liquid medicine and discharges, and is not suitable for the drug release of powder, solid particle.
A kind of miniature releasing device has been proposed in Chinese patent ZL03233001.4, be used for discharging medicine at human body or the intravital digestive tract fixed point of animal, this device comprises that shell, controlling organization, piston, the spring of driven plunger motion, medicinal liquid store appearance storehouse, sharp object array; The principal character of this device is that the medicinal liquid storage warehouse is the making of flexible resilient thin-film material, and medicinal liquid to be discharged is sealed in the medicinal liquid storage warehouse, and the medicinal liquid storage warehouse is the elastic expansion state after being full of medicinal liquid; The bottom of one end of device has the sharp object array, sharp object indicator device inside; The medicinal liquid storage warehouse places between piston and the sharp object array.When device receives external remote signal, piston travels forward under the effect of spring, the medicinal liquid storage warehouse travels forward under the driving of piston and the sharp object that is positioned at the end punctures, and medicinal liquid discharges, and further is discharged in the digestive tract by the aperture on the shell.There is following shortcoming in this device, and at first, the frictional force of the inwall of expansible medicinal liquid storage warehouse and shell is bigger, and the driving force of spring might can't promote medicinal liquid storage warehouse motion, can't with the effect of sharp object array, cause release failure; Secondly, the medicinal liquid storage warehouse medicine difficulty of packing into, the medicinal liquid storage warehouse after the powder charge damages in assembling process easily.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, a kind of simple in structure, easy to use, digestive tract medicine that reliability is high fixed point releasing device is provided.
Technical scheme of the present invention is as follows: this device comprises external remote-control gear and the electronic capsule that can swallow, electronic capsule comprises shell, battery, remote control module, spring, piston, medicine holding bin, the drug release passage mechanism, the telltale mark source, piston, cavity between outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, remote control module comprises a miniature heater element, low-melting polymer line is fixed on a end in the electronic capsule shell with piston, spring be in compressive state and be restrained to piston and remote control module between, polymer line contacts with miniature heater element.Remote control module comprises reception antenna, resonance circuit, rectification circuit, votage control switch module.Wherein the votage control switch module is that metal oxide semiconductor field effect is answered transistor or photo-coupled relay or micromachine electrical switch.Reception antenna is inserted or is wrapped between the inwall and outer wall of shell, the remote signal that the outer remote-control gear of the direct coupling body of reception antenna is launched and form the resonance potential of big magnitude of voltage, this resonance potential or the resonance potential behind over commutation are directly controlled the conducting of votage control switch module with closed.
Work process of the present invention is: the volunteer, after perhaps the patient swallows electronic capsule, utilize the radioscopy machine, B ultrasonic, existing armarium such as ECT, the perhaps special-purpose position of locating and tracking system monitoring electronic capsule in digestive tract, when arriving the appointed area, external remote-control gear sends remote signal, the remote control module that is positioned at electronic capsule inside receives turning circuit after the remote signal, miniature heater element is under the power supply effect, temperature raises rapidly and the fusing polymer line, piston the compression spring driving under to the other end motion of electronic capsule, under the pressure effect that the piston motion produces, the drug release passage mechanism is opened, and the medicine in the medicine holding bin discharges by the drug release passage mechanism that has been opened.
The present invention compared with prior art has following technique effect:
1) simple in structure.The present invention mainly is made of the electronic capsule modularity battery, remote control module, spring, piston, drug release passage mechanism, simple in structure, makes assembling and manufacturing be more prone to.
2) easy to use.Among the present invention, medicine holding bin is made of the cavity between piston, outer casing inner wall and the drug release passage mechanism, and is simple in structure, and with respect to the balloon capsule medicine holding bin that flexible material is made, medicine is packed into more simple, and is easy to use.
3) discharge the reliability height.Among the present invention, opening of drug release passage mechanism utilizes the pressure of piston actuated to open, and driving pressure can be directly delivered to the drug release passage mechanism by medicine, and the drug release passage mechanism can in time be opened, and discharges reliability and is improved.
Description of drawings
Fig. 1 is a system of the present invention composition diagram;
Fig. 2 is an electronic capsule structure chart of the present invention;
Fig. 3 is a remote control module structure chart of the present invention;
Fig. 4 is an external remote-control gear structure chart of the present invention;
Fig. 5 is the sending antenna structure sketch map of external remote-control gear of the present invention;
In Fig. 1 to Fig. 5:
1-external remote-control gear, 2-electronic capsule, 3-shell, 4-battery, 5-remote control module, 6-spring, 7-piston, 8-drug release passage mechanism, 9-telltale mark source, 10-miniature heater element, 11-polymer line, 12-medicine holding bin, 13-reception antenna, 14-manhole, 15-round and elastic sealing-plug, 16-votage control switch module, 17-resonance circuit, 18-rectification circuit, 19-power generator, 20-impedance matching network, 21-transmission antenna group, 22-transmitting antenna
The specific embodiment
A kind of digestive tract medicine fixed point releasing device, comprise external remote-control gear [1] and the electronic capsule [2] that can swallow, electronic capsule [2] comprises shell [3], battery [4], remote control module [5], spring [6], piston [7], drug release passage mechanism [8], telltale mark source [9], and the cavity between piston [7] and the drug release passage mechanism [8] constitutes medicine holding bin [12].
Drug release passage mechanism [8] comprises a manhole [14] and round and elastic sealing-plug [15], manhole [14] diameter 3mm between the 10mm, length at 1mm between the 5mm; Round and elastic sealing-plug [15] diameter 3mm between the 10mm, length at 1mm between the 5mm; Round and elastic sealing-plug [15] places manhole [14], is the state of being sealed and matched, and the frictional force between manhole [14] and the round and elastic sealing-plug [15] is between 0.5 newton and 10 newton.In order to increase the sealing reliability of sealing-plug, can be processed as the rag structure of helicitic texture or other increase frictional force on the inwall of manhole [14].Drug release passage mechanism [8] also can be check valve [16] structure.
Telltale mark source [9] is permanent magnet or is the medical radioactive tracer; For conserve space, telltale mark source [9] can be embedded into or be encapsulated among the piston [7].
Remote control module [5] comprises reception antenna [13], resonance circuit [17], rectification circuit [18], votage control switch module [16].Induced resonance potential of reception antenna [13] or the resonance potential behind over commutation are directly controlled the conducting of votage control switch module [16] with closed.For improving space availability ratio, reception antenna [13] can be inserted or be wrapped between the inwall and outer wall of shell [3].Votage control switch module [16] is answered transistor or photo-coupled relay or micromachine electrical switch for metal oxide semiconductor field effect.
External remote-control gear [1] comprises that frequency range is power generator [19], impedance matching network [20] and the transmission antenna group [21] of high frequency or radio frequency.Transmission antenna group [21] comprise three pairs mutually perpendicular or become the transmitting antenna [22] of certain angle mutually, three pairs of transmitting antennas [22] are launched remote signal simultaneously or in a certain order.
It is as follows that present embodiment gets work process: the volunteer, after perhaps the patient swallows electronic capsule [2], utilize the radioscopy machine, B ultrasonic, existing armarium such as ECT, the perhaps special-purpose position of locating and tracking system monitoring electronic capsule [2] in digestive tract, when arriving area-of-interest, external remote-control gear [1] sends remote signal, remote control module [5] receives turning circuit after the remote signal, miniature heater element [10] is under the effect of power supply [4], temperature raises rapidly and fusing polymer line [11], the spring [6] that is in compressive state is released, piston [7] under the driving of spring [6] to the other end motion of electronic capsule [2], under the pressure effect that the piston motion produces, drug release passage mechanism [8] is opened, and the medicine in the storage warehouse [12] discharges by the drug release passage mechanism [8] that has been opened.
Fig. 1 is that the system of present embodiment forms, and system comprises external remote control system [1] and electronic capsule [2].The size of electronic capsule is generally: diameter is less than 12mm, and length is generally less than 35mm.
Fig. 2 has provided the kind structure chart of the electronic capsule [2] of present embodiment.Electronic capsule [2] comprises shell [3], battery [4], remote control module [5], compression spring [6], piston [7], drug release passage mechanism [8], telltale mark source [9], and the cavity between piston [7] and the drug release passage mechanism [8] constitutes medicine holding bin [12].Drug release passage mechanism [8] comprises a manhole [14] and round and elastic sealing-plug [15], and round and elastic sealing-plug [15] places manhole [14], is the state of being sealed and matched.In order to increase the sealing reliability of sealing-plug, the inwall of manhole [14] is processed as helicitic texture.Telltale mark source [9] is a permanent magnet, and for conserve space, telltale mark source [9] are embedded in the piston [7].In order to improve space availability ratio, reception antenna [13] can be inserted between the inwall and outer wall of shell [3].When carrying out drug release, piston [7] under the driving of spring [6] to the other end motion of electronic capsule [2], under the pressure effect that the piston motion produces, round and elastic sealing-plug [15] breaks away from from manhole [14], and the medicine in the storage warehouse [12] is by discharging in the manhole [14] that has been opened.Reception antenna [13] is inserted or is wrapped between the inwall and outer wall of shell [3].The outstanding advantage of scheme is: medicine is packed into very convenient, and is fit to the release of multiple pharmaceutical dosage form, for example liquid, powder, granule etc.
Fig. 3 has provided the structure chart of remote control module.Among the figure, remote control module [5] comprises reception antenna [13], resonance circuit [17], rectification circuit [18], votage control switch module [16], and the induced resonance potential of reception antenna [13] is directly controlled the conducting of votage control switch module [16] with closed.Votage control switch module [16] is answered transistor or photo-coupled relay or micromachine electrical switch for metal oxide semiconductor field effect.
Fig. 4 has provided external remote-control gear structure chart.Wherein, external remote-control gear [1] comprises that frequency range is power generator [19], impedance matching network [20] and the transmission antenna group [21] of high frequency or radio frequency.The frequency band of optimizing is generally between 100KHz～30MHz.
Fig. 5 has provided the structure of the transmission antenna group [21] of external remote-control gear.Transmission antenna group [21] comprise three pairs mutually perpendicular or become the transmitting antenna [22] of certain angle mutually, the three pairs of transmitting antennas are simultaneously or launch remote signal in a certain order.The advantage of this scheme is: from a plurality of direction emission remote signals, can reduce the influence of sense to reliability, improve the reliability of successful triggering.
Claims (5)
1. digestive tract medicine fixed point releasing device, comprise external remote-control gear and the electronic capsule that can swallow, electronic capsule comprises shell, battery, remote control module, spring, piston, medicine holding bin, the drug release passage mechanism, the telltale mark source, its piston, cavity between outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, remote control module comprises a miniature heater element, low-melting polymer line is fixed on a end in the electronic capsule shell with piston, spring be in compressive state and be restrained to piston and remote control module between, polymer line contacts with miniature heater element, remote control module is connected circuit after receiving the remote signal of external remote-control gear emission, miniature heater element temperature under the power supply effect raises rapidly, the fusing polymer line, the spring that is in compressive state obtains discharging, piston under the driving of spring to the other end motion of electronic capsule, the drug release passage mechanism is opened under the pressure effect that the piston motion produces, and the medicine in the medicine holding bin discharges by the drug release passage mechanism that has been opened; It is characterized in that its remote control module comprises reception antenna, resonance circuit, rectification circuit, votage control switch module, induced resonance potential of reception antenna or the resonance potential behind over commutation are directly controlled the conducting of votage control switch module with closed, the votage control switch module is that metal oxide semiconductor field effect is answered transistor or photo-coupled relay or micromachine electrical switch, and reception antenna is inserted or is wrapped between the inwall and outer wall of shell.
2. digestive tract medicine according to claim 1 fixed point releasing device is characterized in that the drug release passage mechanism comprises a manhole and round and elastic sealing-plug, the manhole diameter 3mm between the 10mm, length at 1mm between the 5mm; Round and elastic sealing-plug diameter 3mm between the 10mm, length at 1mm between the 5mm; The round and elastic sealing-plug places manhole, is the state of being sealed and matched, and the frictional force between manhole and the round and elastic sealing-plug is between 0.5 newton and 10 newton.
3. digestive tract medicine according to claim 2 fixed point releasing device is characterized in that having helicitic texture on the inwall of manhole.
4. digestive tract medicine fixed point releasing device according to claim 1 is characterized in that external remote-control gear comprises high frequency or radio-frequency power generator, impedance matching network and transmission antenna group.
5. digestive tract medicine fixed point releasing device according to claim 4, it is characterized in that transmission antenna group comprise three pairs mutually perpendicular or become the transmitting antenna of certain angle mutually, the three pairs of transmitting antennas are simultaneously or launch remote signal in a certain order.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100408093A CN1304070C (en) | 2004-09-29 | 2004-09-29 | Device for releasing medication for alimentary tract at fixed point |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100408093A CN1304070C (en) | 2004-09-29 | 2004-09-29 | Device for releasing medication for alimentary tract at fixed point |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1600279A CN1600279A (en) | 2005-03-30 |
| CN1304070C true CN1304070C (en) | 2007-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100408093A Expired - Fee Related CN1304070C (en) | 2004-09-29 | 2004-09-29 | Device for releasing medication for alimentary tract at fixed point |
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| CN (1) | CN1304070C (en) |
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| CN100376299C (en) * | 2005-08-19 | 2008-03-26 | 华南理工大学 | Chemical reaction gas pressure type microcapsule medicine release method and apparatus thereof |
| CN100588378C (en) * | 2006-11-16 | 2010-02-10 | 重庆大学 | Alimentary tract drug release remote controlled capsule system |
| CN100482294C (en) * | 2006-12-26 | 2009-04-29 | 重庆大学 | Remote controlled modicine reliesing electronic capsule capable of partly degradation |
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| CN109172032B (en) * | 2018-10-13 | 2020-06-19 | 刘劼 | Microsphere catheter wire-tying device for rat MCAO model |
| CN111760177B (en) * | 2020-06-16 | 2022-04-29 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery |
| CN113545734B (en) * | 2021-08-31 | 2022-06-07 | 武汉大学 | Magnetic control dual-drive medicine applying capsule robot |
| CN113576374B (en) * | 2021-08-31 | 2022-08-30 | 武汉大学 | Plate spring driven magnetic control medicine applying capsule robot |
| CN113576373B (en) * | 2021-08-31 | 2022-08-30 | 武汉大学 | Magnetic control micro-needle puncture medicine application capsule |
| CN113769250B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
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|---|---|---|---|---|
| EP0149510A2 (en) * | 1984-01-06 | 1985-07-24 | Eli Lilly And Company | sustained release device for ruminants |
| US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
| JPH09122131A (en) * | 1995-10-30 | 1997-05-13 | Yakult Honsha Co Ltd | Capsule for medical use |
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN2619325Y (en) * | 2003-05-27 | 2004-06-02 | 重庆大学 | Micro radio remote control switch capable of implanting in biological body |
| CN1519040A (en) * | 2003-01-22 | 2004-08-11 | 皮喜田 | Minitype drug releasing device for use of alimentary canal |
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2004
- 2004-09-29 CN CNB2004100408093A patent/CN1304070C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0149510A2 (en) * | 1984-01-06 | 1985-07-24 | Eli Lilly And Company | sustained release device for ruminants |
| US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
| JPH09122131A (en) * | 1995-10-30 | 1997-05-13 | Yakult Honsha Co Ltd | Capsule for medical use |
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN1519040A (en) * | 2003-01-22 | 2004-08-11 | 皮喜田 | Minitype drug releasing device for use of alimentary canal |
| CN2619325Y (en) * | 2003-05-27 | 2004-06-02 | 重庆大学 | Micro radio remote control switch capable of implanting in biological body |
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| Publication number | Publication date |
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| CN1600279A (en) | 2005-03-30 |
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