CN1080863A - A kind of health medicine compositions of relieving the effect of alcohol - Google Patents
A kind of health medicine compositions of relieving the effect of alcohol Download PDFInfo
- Publication number
- CN1080863A CN1080863A CN 93107382 CN93107382A CN1080863A CN 1080863 A CN1080863 A CN 1080863A CN 93107382 CN93107382 CN 93107382 CN 93107382 A CN93107382 A CN 93107382A CN 1080863 A CN1080863 A CN 1080863A
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- pericarpium citri
- citri reticulatae
- leaf
- stem
- reticulatae viride
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Abstract
The invention discloses a kind of antialcoholic pharmaceutical composition, it is made up of Flos puerariae lobatae, Pericarpium Citri Reticulatae Viride and stem and leaf of Radix Ginseng saponin, has the health-care effect of relieving the effect of alcohol, and can make capsule, tablet, electuary, medicinal tea, oral liquid.
Description
The present invention is a kind of antialcoholic medicine, it be a kind of be raw material with the Chinese herbal medicine, through the Chinese medicine preparation that specific process technology is made, have and relieve the effect of alcohol, health-care effect belongs to field of traditional Chinese.
Drinking is most a kind of hobbies of people, but the excessive consumption of alcohol meeting brings serious damage to human body.After wine entered human body, ethanol was absorbed into blood, with the also corresponding increase of the increase blood-alcohol concentration of drinking amount, when blood-alcohol concentration reaches 0.5% when above, height inhibition, lethargy, disturbance of consciousness, gatism can appear, as in time not rescuing, and can be dead because of respiratory paralysis.Therefore for the alcoholic, be a long felt need for a kind of medicine that relieves the effect of alcohol and alleviate and treat its alcoholism.Still there is not at present a kind of antialcoholic drug of determined curative effect to select to use clinically for the doctor.
The object of the invention provides a kind of pharmaceutical preparation of relieving the effect of alcohol.
Another object of the present invention provides the processing technique of above-mentioned sobering preparation.
The relieve the effect of alcohol prescription and the preparation process of medicament of the present invention is as follows:
Prescription is formed: Flos puerariae lobatae, Pericarpium Citri Reticulatae Viride, stem and leaf of Radix Ginseng saponin.
The amount ratio of each component is (weight ratio) in the above-mentioned prescription:
Flos puerariae lobatae: Pericarpium Citri Reticulatae Viride: stem and leaf of Radix Ginseng saponin=25-35: 5-15: 0.5-2.
Optimum weight ratio between the each component is:
Flos puerariae lobatae: Pericarpium Citri Reticulatae Viride: stem and leaf of Radix Ginseng saponin=30: 10: 1.
The stem and leaf of Radix Ginseng saponin that uses in the above-mentioned prescription is the light brown powder of extracting from Stem and leaf of Radix Ginseng that is, and has hygroscopic saponin extract (referring to the 18th the 10th phase of volume of: " Acta Pharmaceutica Sinica " nineteen eighty-three).The stem and leaf of Radix Ginseng saponin that the present invention uses should meet the prescription that the Liao Dynasty defends the accurate word of medicine (84) 942-66 number " about the reply of the provisional quality standard of ginsenoside " certification.
In actual preparation process, above-mentioned prescription also can add conventional drug excipient, as starch, dextrin etc.The addition of excipient is not vital for the influence of drug effect, and those of skill in the art can select its usual amounts according to actual needs.
Above-mentioned pharmaceutical composition can be prepared into different dosage forms, as electuary, medicinal tea, tablet, capsule, oral liquid etc.
Now its machining process is described in conjunction with capsule formulation.
Two, preparation technology
(1) technological process
Raw material → decoction → filtration → concentrate → add ginsenoside → drying → pulverize → sieve → add appropriate amount of starch mixing → encapsulated → pack.
(2) operating process
By the material quantity in the prescription composition, take by weighing Flos puerariae lobatae and Pericarpium Citri Reticulatae Viride and boil husky cloth filtration in 1 hour with 12 times of water-wet post-heating.Medicinal residues added 7-8 times of water boil 40 minutes again, filtered by last method.Merging filtrate is evaporated to scattered paste shape, adds the recipe quantity stem and leaf of Radix Ginseng saponin, 60-80 ℃ of following drying under reduced pressure.Dry thing is pulverized the back and is crossed 80 mesh sieves, and dry powder adds during the appropriate amount of starch mixing incapsulates, and capsule core material is all about 0.48 gram.
(3) description of the process
1. the foundation of extracting with decocting method
Flos puerariae lobatae is a monarch drug among the we.The active ingredient of mainly sobering up in the Flos puerariae lobatae is a water-soluble components, so can better bring into play drug effect with decocting method.The effective constituent that mainly contains in the Pericarpium Citri Reticulatae Viride is a flavonoid compounds, and dissolubility is preferably also arranged in hot water, so decocting method is adopted in the extraction of this prescription.
2. the examination of decocting time
This prescription main component Flos puerariae lobatae and Pericarpium Citri Reticulatae Viride, they contain isoflavone and flavanone respectively, and absorption maximum is arranged near the 270nm in UV, can be used as main component and examine or check extraction process.The UV absorption spectrum of total extract is seen accompanying drawing.
Extract altogether three times after feeding intake by recipe quantity, count every sampling in 20 minutes from boiling time, at 275nm place mensuration ultraviolet absorptivity, numerical value sees Table 1 and Fig. 1.Fig. 1 is the dissolution rate curve.
Table 1 extraction time and extract percentile experimental result
| Extraction time | 1 | 2 | 3 |
| Trap during each time extracting solution balance | 0.51 | 0.21 | 0.10 |
| Extract percentage rate (%) | 64.8 | 23.9 | 11.4 |
Conclusion can draw following results from last table and illustrated experimental result:
Be advisable with 1 hour when (1), decocting extraction for the first time.Because trap has reached balance at 60 minutes and has no longer raise when extracting for the first time, illustrate to reach the maximum extracted rate, should be again novel solvent more.
(2), for the second time decoct when extracting, extract trap and no longer changed after 40 minutes, also explanation is extracted more complete.
3. decoct the decision of number of times
Extract altogether three times after feeding intake by recipe quantity, measure purple place trap.Trap shown in the table two is represented extraction ratio.Then first, second and third extraction ratio of frying in shallow oil is respectively 64.8%, 23.9% and 11.4%.Wherein first and second is fried in shallow oil and accounts for 88.7% of total extraction ratio, the effective ingredient overwhelming majority in the crude drug is extracted, and determines only to extract twice so consider factors such as cost and energy resource consumption.
4. the examination of paste-forming rate:
We have carried out the examination of three batches of raw material paste-forming rates altogether, and it is about 17% → 20% that extracted twice liquid concentrates back extractum yield.The results are shown in following table:
| Lot number | Inventory (g) | Extractum amount (g) | Paste-forming rate (%) |
| 920417 | 240 | 40 | 16.7 |
| 920418 | 240 | 42 | 17.5 |
| 920419 | 240 | 47 | 19.6 |
The medicine that relieves the effect of alcohol of the present invention have good relieve the effect of alcohol, anti-alcohol function.When showing by the roller experiment and the test of reviving, medicine of the present invention has the ability of anti-acute alcoholism preferably, and obviously postpones animal and begin the drunk time, and when shortening the lethargy of animal.It is the sure antialcoholic drug of a kind of effect.
Embodiment 1
Get Flos puerariae lobatae 1500g, Pericarpium Citri Reticulatae Viride 500g adds 12 times of water infiltration post-heating and boiled 1 hour, husky cloth filters, and medicinal residues add 7-8 times of water boil 40 minutes again, and the husky cloth of reuse filters, merging filtrate, be evaporated to scattered paste shape, add stem and leaf of Radix Ginseng saponin 50g, 60-80 ℃ of following drying under reduced pressure, dry thing is pulverized the back and is crossed 80 mesh sieves, add appropriate amount of starch mixing 500g altogether, in incapsulating, the capsule thing is about 0.5g.
Claims (9)
1, a kind of antialcoholic pharmaceutical composition, it is characterized in that it is made up of following component: Flos puerariae lobatae, Pericarpium Citri Reticulatae Viride, stem and leaf of Radix Ginseng saponin, the weight ratio between the each component is a Flos puerariae lobatae: Pericarpium Citri Reticulatae Viride: stem and leaf of Radix Ginseng saponin=25-35: 5-15: 0.5-2.
2,, it is characterized in that the weight ratio between the each component is according to the pharmaceutical composition of claim 1:
Flos puerariae lobatae: Pericarpium Citri Reticulatae Viride: stem and leaf of Radix Ginseng saponin=30: 10: 1.
3,, it is characterized in that to add pharmaceutically acceptable excipient according to the pharmaceutical composition of claim 1.
4,, it is characterized in that said excipient is a starch according to the pharmaceutical composition of claim 3.
5, a kind of preparation method of antialcoholic drug compositions, it is characterized in that with Flos puerariae lobatae, Pericarpium Citri Reticulatae Viride, stem and leaf of Radix Ginseng saponin=0.5-35: 5-15: the 0.5-2(weight ratio) be raw material, earlier Flos puerariae lobatae, Pericarpium Citri Reticulatae Viride are decocted with water, filtering and concentrating, add the ginsenoside, drying and crushing is sieved, add the appropriate amount of starch mixing, make pharmaceutical dosage form.
6, according to the preparation method of claim 5, it is characterized in that taking by weighing Flos puerariae lobatae and Pericarpium Citri Reticulatae Viride and boil husky cloth filtration in 1 hour with 12 times of water-wet post-heating, medicinal residues added 7-8 times of water boil 40 minutes again, filtered merging filtrate by last method, be evaporated to scattered paste shape, add the recipe quantity stem and leaf of Radix Ginseng saponin, 60-80 ℃ of following drying under reduced pressure, dry thing is pulverized the back and is crossed 80 mesh sieves, dry powder adds the appropriate amount of starch mixing, makes pharmaceutical dosage form.
7, according to the preparation method of claim 6, said pharmaceutical dosage form is capsule, tablet and electuary.
8, according to the preparation method of claim 6, said pharmaceutical dosage form is a medicinal tea.
9,, it is characterized in that said dosage form is an oral liquid according to the preparation method of claim 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107382 CN1080863A (en) | 1993-06-28 | 1993-06-28 | A kind of health medicine compositions of relieving the effect of alcohol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107382 CN1080863A (en) | 1993-06-28 | 1993-06-28 | A kind of health medicine compositions of relieving the effect of alcohol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1080863A true CN1080863A (en) | 1994-01-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93107382 Pending CN1080863A (en) | 1993-06-28 | 1993-06-28 | A kind of health medicine compositions of relieving the effect of alcohol |
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| CN (1) | CN1080863A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055211C (en) * | 1994-04-07 | 2000-08-09 | 任贵兴 | Antialcoholic liver-protecting preparation and its preparing method |
| US6399072B1 (en) * | 1996-03-13 | 2002-06-04 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of alcoholism |
| US6509381B2 (en) * | 1996-03-13 | 2003-01-21 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions |
| CN103461871A (en) * | 2013-07-29 | 2013-12-25 | 安徽燕之坊食品有限公司 | Sobering-up foodstuff and preparation method thereof |
| CN111956713A (en) * | 2020-09-03 | 2020-11-20 | 华熙生物科技股份有限公司 | Hangover-alleviating and liver-protecting composition containing hyaluronic acid and application thereof |
-
1993
- 1993-06-28 CN CN 93107382 patent/CN1080863A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055211C (en) * | 1994-04-07 | 2000-08-09 | 任贵兴 | Antialcoholic liver-protecting preparation and its preparing method |
| US6399072B1 (en) * | 1996-03-13 | 2002-06-04 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of alcoholism |
| US6509381B2 (en) * | 1996-03-13 | 2003-01-21 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions |
| US6518319B1 (en) * | 1996-03-13 | 2003-02-11 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of female symptoms |
| US6900240B2 (en) | 1996-03-13 | 2005-05-31 | Archer-Daniels-Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of cancer |
| CN103461871A (en) * | 2013-07-29 | 2013-12-25 | 安徽燕之坊食品有限公司 | Sobering-up foodstuff and preparation method thereof |
| CN111956713A (en) * | 2020-09-03 | 2020-11-20 | 华熙生物科技股份有限公司 | Hangover-alleviating and liver-protecting composition containing hyaluronic acid and application thereof |
| CN111956713B (en) * | 2020-09-03 | 2021-10-15 | 华熙生物科技股份有限公司 | Hangover-alleviating and liver-protecting composition containing hyaluronic acid and application thereof |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |