CN105380731A - Porous tantalum metal bone connector and application thereof - Google Patents
Porous tantalum metal bone connector and application thereof Download PDFInfo
- Publication number
- CN105380731A CN105380731A CN201510673087.3A CN201510673087A CN105380731A CN 105380731 A CN105380731 A CN 105380731A CN 201510673087 A CN201510673087 A CN 201510673087A CN 105380731 A CN105380731 A CN 105380731A
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- Prior art keywords
- bone
- pulp cavity
- tantalum
- porous tantalum
- tantalum metal
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
Abstract
The invention discloses a porous tantalum metal bone connector which is applicable to treatment of limb fracture nonunion, bone nonunion, bone defects and the like. The porous tantalum metal bone connector comprises a body. The two ends of the body are each provided with a medullary space handle. The medullary space handles and the body are integrally formed. At least one screw hole is formed in each medullary space handle. The porous tantalum metal bone connector further comprises connection screws matched with the screw holes. According to the porous tantalum metal bone connector, the structure that the medullary space handles and the body are integrally formed is adopted, the better mechanical strength is achieved, and the risk of prosthesis breakage is effectively reduced. Screw rotating prevention grooves are formed in the medullary space handles, the bone connector and corresponding bone tissue can be fixed, and the problem that an artificial prosthesis is likely to rotate and loosen is effectively reduced. According to the porous tantalum metal bone connector, the preparation method is simple, the cost is low, implementation and clinical application are facilitated, and the requirement of a majority of patients is met.
Description
Technical field
The present invention relates to a kind of medical permanent implantation object, particularly a kind of medical implant porous tantalum metal bone adapter for the treatment of for extremity fracture disunion and bone does not connect, Cranial defect etc.
Background technology
After bone tumour resection, after Cranial defect, extremity long bone fracture, bone does not connect and defect etc. are clinical common diseases.How the large section Bone and joint defects caused after bone tumour resection is repaired is a great problem perplexing orthopaedics always.Although this Cranial defect can be repaired through various ways (as bone grafting joint fusion, artificial prosthesis and traditional bone and osteochondral allograft etc.), various method all has its pros and cons.The frozen homologous osteoarthrosis that adopts is transplanted more clinically at present, but the bone connecting portion of large section osteoarticular allograft needs the long duration to heal, and some patients is disunion then, causes bone does not connect, bone delay in healing occurring, the complication such as allogeneic bone fracture.After extremity long bone fracture, bone does not connect and defect often adopt Periosteal Flaps and autologous bone, artificial bone etc. to carry out transplantation treatment at present, but by a large amount of experiments and clinical confirmation, there is biomechanics underbraced in simple bone collection, the shortcomings such as bone resorption, thus need to have the bone implant that biomechanics can be provided to support.
Porous medical metal implanted material has the important and special purposes such as treatment osseous tissue wound and induction osteanagenesis, and existing common this kind of material has porous stainless steel, POROUS TITANIUM etc.As the porous embedded material that osseous tissue wound, defect treatment use, its porosity should reach 30 ~ 85%, and hole preferably all connected sum be uniformly distributed, or aperture sections connected sum is uniformly distributed as required, make it both consistent with the bone growth of human body, alleviate again the weight of material itself, implant with applicable human body and use.
Metal tantalum waits side effect to human non-toxic's evil, and have good biocompatibility and mechanical property, its porous material is expected to alternative aforementioned conventional medical metal biomaterial, becomes the primary biological material in Cranial defect necrosis therapeutic field.Along with the develop rapidly of domestic and international medical science, to the further cognition of tantalum as body implanting material, the demand of people to human body implantation porous metals tantalum material becomes more and more urgent, also more and more higher to its requirement.Wherein as the medical embedded metal tantalum of porous, if the very high physical and mechanical properties being uniformly distributed interconnected pore and adapting with human body can be had, then it is the heavy connection constituent material ensureing freshman bone tissue's normal growth.
About this kind of material of porous tantalum, US5282861 discloses and is a kind ofly applied to cancellous bone implants, the porous tantalum material of biological cells and tissues sensor and preparation thereof.This porous tantalum is made up of pure business tantalum, it carries out carbon skeleton that thermal degradation obtains for support with polyurethane precursor, this carbon skeleton is multiple dodecahedron, it is mesh-like structure in it, entirety spreads all over micropore, porosity can up to 98%, then by commercially pure tantalum by the methods combining of chemical vapour deposition, infiltration to carbon skeleton to form porous metals micro structure, abbreviation chemical deposition.The tantalum layer thickness on its surface of porous tantalum material that this method obtains is between 40 ~ 60 μm; In whole porous material, tantalum proportion accounts for 99%, and carbon skeleton weight then accounts for about 1%.Document is recorded further, the comprcssive strength 50 ~ 70MPa of this porous material, elastic modelling quantity 2.5 ~ 3.5GPa, tensile strength 63MPa, amount of plastic deformation 15%.Such as, but using its porous tantalum as medical embedded material, the mechanical property of its material is obvious weak point as ductility has, and can have influence on the follow-up processing to porous tantalum material itself, the cutting, boring etc. of profiled member.
At present, adopt the medical implant for defect filling that the existing treatment for bone does not connect and defect etc. has the materials such as titanium to make, that one is made up of far-end pulp cavity handle, proximal medullary cavity handle and 2 pieces of attachment screws, insider's custom is called " segmental pattern artificial prosthesis ", embedded implantation in clinical treatment, by being fixed by far-end pulp cavity handle, proximal medullary cavity handle and 2 pieces of attachment screws; " the segmental pattern artificial prosthesis " of this result lacks effective biomechanics and supports and good self-bone grafting nucleus formation, separately needs the clinical drawback that second operation taking-up etc. is more, thus effectively can not be widely used in clinical treatment.Further, bone adapter is mainly applied to the postoperative and large segmental bone defect of bone tumour resection; But there is complex structure, technical requirement is high, and it is higher that junction loosens probability, Bone Ingrowth is not enough, and anti-rotation performance deficiency waits some row problems.
Summary of the invention
The object of the invention is to for existing bone adapter Problems existing, provide a kind of for medical embedded porous tantalum metal bone adapter.This bone connector construction is simple, have good mechanical strength and anti-rotation, loosing prevention performance, have the high tissue compatibility and biomechanical property simultaneously, osseous tissue can be induced to generate, be convenient to growing into of osseous tissue.
Technical scheme of the present invention is as follows:
A kind of bone adapter, comprise body, the two ends of described body are respectively arranged with the pulp cavity handle that can insert medullary cavity, described pulp cavity handle and this body by integral forming, and described pulp cavity handle is respectively arranged with at least one screw hole.
In preferred technical scheme, the pulp cavity handle at described body two ends is respectively provided with two screw holes.
In technical scheme of the present invention, described porous tantalum metal bone adapter also comprises the attachment screw matched with described screw hole, and the two ends of described attachment screw are equipped with prevents revolving screw thread.Screw hole and chain attachment screw are for being threaded.
In technical scheme of the present invention, described body is preferably cylindrical, and described pulp cavity handle is preferably conical, but the shape of described pulp cavity handle and body does not get rid of other shapes, and the feature etc. according to implant site can adopt any shape.
In further preferred technical scheme, body of the present invention is cylindrical, described pulp cavity handle is conical, pulp cavity shank diameter from body phase company headquarters to ends taper, wherein with the pulp cavity shank diameter of body connecting portion and the diameter of its end than being 10:4 ~ 7.
In technical scheme of the present invention, described pulp cavity shank diameter from body phase company headquarters to ends taper, with the diameter of the pulp cavity shank diameter of body connecting portion and end than being preferably 10:4 ~ 7.
In technical scheme of the present invention, be preferably 4 ~ 7:10 with the pulp cavity shank diameter of body connecting portion and the ratio of body diameter, be more preferably 6:10.
In technical scheme of the present invention, the length of described pulp cavity handle and the length of body, than being preferably 1:1 ~ 3, are more preferably 1:2.
In technical scheme of the present invention, described pulp cavity handle is preferably conical, and described body is preferably cylindrical, but the shape of described pulp cavity handle and body does not get rid of other shapes, and the feature etc. according to implant site can adopt other suitable shapes.
In the present invention, the shape in the aperture of the screw hole that pulp cavity handle is arranged can be circular, hexagon.
Porous tantalum metal bone adapter of the present invention, body is cylinder, similar to the shape of bone, can the defective region of filling bone, two ends pulp cavity handle is conical structure, favourable insertion pulp cavity, and screw hole is set, the fixing of two ends can be carried out and prevent the rotation of bone adapter and loosen; Described body and two ends pulp cavity handle length and diameter have certain ratio with the length of body and diameter respectively, to play the effect of body and two ends pulp cavity handle to greatest extent, namely the implantation being more conducive to pulp cavity two ends, with fixing, be also conducive to osseous tissue and carry out creeping substitution growth etc.Porous tantalum metal bone adapter of the present invention adopts pulp cavity handle and the integrated structure of body, relative to existing " segmental pattern " artificial prosthesis, has better mechanical strength, effectively reduces the risk of prosthese fracture, is conducive to patient's early ambulation.On the other hand, the present invention is provided with at least more than one screw hole on pulp cavity handle, the attachment screw matched with it can be selected to carry out being screwed into, be threaded fixing.Bone adapter can be inserted pulp cavity, after pulp cavity is inserted respectively in two ends, adopt selection two ends to have the anti-attachment screw revolving screw thread and be screwed into, its anti-rotation can be strengthened and reliable effect of pressurizeing.Because the profile and skeleton physiology structure that newly design this kind of bone adapter are comparatively close, better meet the conduction of lower limb Mechanics of Machinery, can effectively avoid the refracture caused by stress shielding to occur; Attachment screw, its two ends are equipped with anti-revolves screw thread, can better play pressurization and prevent the spinfunction of bone adapter.
Further, the material that described bone adapter adopts utilizes chemical gaseous phase depositing process, tantalum metallic compound is reduced to tantalum metal powder, and uniform deposition forms tantalum coating in graphitic carbon skeleton surface and prepares, and wherein said tantalum metallic compound is tantalic chloride, the one of fluoridizing in tantalum; The porosity >70% of described graphitic carbon skeleton, aperture is 200 ~ 600 μm; The thickness of described tantalum coating is 40 ~ 60 μm.
The present invention also provides the preparation method of above-mentioned porous tantalum metal bone adapter, and this preparation method comprises the steps:
(1) by above-mentioned graphitic carbon skeleton dilute hydrochloric acid etch 10min, dry up with nitrogen with after water and ethanol purge successively, insert in reative cell;
(2) pass into process gas and hydrogen in reative cell simultaneously, at 900-1050 DEG C, under vacuum 10Pa condition, reaction 4-6 hour; Wherein said process gas comprises tantalum metallic compound and carrier gas, tantalum metallic compound is put into carrying shield, is heated to 120-250 DEG C, with 300 DEG C of noble gases for carrier gas passes into reative cell; The flow of described process gas is 80 ~ 100ml/min; The flow of described hydrogen is 100 ~ 150ml/min.
In above-mentioned preparation method, one or both the mixing in the preferred argon of described noble gas, helium, most preferably argon.
After porous tantalum metal bone adapter of the present invention can be applied to bone does not connect, Cranial defect, tumor resection, prosthese rebuilds the medical implant for the treatment of.
Beneficial effect of the present invention: porous tantalum metal bone adapter of the present invention adopts pulp cavity handle and the integrated structure of body, relative to existing " segmental pattern " artificial prosthesis, there is better mechanical strength, it more meets the physiological structure of bone, can effective conductive mechanical mechanics, the risk of effective minimizing prosthese fracture, prevents the refracture of the fracture site caused by stress shielding; And screw hole is provided with on pulp cavity handle, utilize and can carry out fixing of bone adapter and corresponding osseous tissue with the attachment screw of its coupling, and be equipped with at the two ends of described attachment screw and prevent revolving screw thread, better can play pressurization, effectively reduce the problem that existing " segmental pattern " artificial prosthesis easily rotates and loosens.Porous tantalum metal bone adapter of the present invention is conducive to the generation of area of new bone and the effect of replacement bone, especially after bone does not connect and tumor resection defect etc. treatment in have good clinical effectiveness, overcome existing " stage type artificial prosthesis " effect on clinical treatment bad wait not enough.On the other hand, the material of porous tantalum metal bone adapter of the present invention has dodecahedron space network, its structure and Grafting Cancellous Bone Bolt girder similar, there is the high tissue compatibility, osseous tissue can be induced to generate, be convenient to growing into of osseous tissue; And there is stronger biomechanical property, certain mechanical support can be provided, reach the object of induction and replacement bone tissue.Porous tantalum metal bone adapter of the present invention, preparation method is simple, cost is low, is conducive to implementing and clinical practice, is suitable for the needs of extensive patients.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described:
Fig. 1 is the structural representation of porous tantalum metal bone adapter of the present invention.
Fig. 2 is the structural representation of attachment screw of the present invention, and the screw hole of this attachment screw and bone adapter of the present invention matches.
Drawing reference numeral: 1, body, 2, pulp cavity handle, 3, screw hole, 4, attachment screw, 5, anti-ly revolve screw thread
Detailed description of the invention
Following non-limiting example can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.
Embodiment 1
As shown in Figure 1, a kind of porous tantalum metal bone adapter, comprise body 1, the two ends of described body are respectively arranged with pulp cavity handle 2, and pulp cavity handle 2 is one-body molded with body 1, and the pulp cavity handle 2 at described body 1 two ends respectively arranges two screw holes 3; Described body 1 is cylindrical, massive structure, and described pulp cavity handle 2 is conical, massive structure, pulp cavity handle 2 diameter from body 1 phase company headquarters to ends taper, with the diameter of pulp cavity handle 2 diameter of body 1 connecting portion and its end than being 2:1.Wherein, described is 1:2 with pulp cavity handle 2 diameter of body 1 connecting portion and the ratio of body 1 diameter, and the length of described pulp cavity handle 2 and the length of body 1 are than being 1:2.
Described bone adapter also comprises the attachment screw 4 matched with described screw hole 3, and the two ends of attachment screw are provided with anti-ly revolves screw thread 5, screw hole with link screw for being threaded.
After described bone adapter can be applicable to bone does not connect, Cranial defect, tumor resection, prosthese rebuilds the medical implant for the treatment of, during use, by fracture site and pulp cavity, clean out the granulation tissue of necrotic bone tissue and surrounding hypertrophy, after fresh blood oozes out, touch choose appropriate size bone adapter according to examination, first insert one end, adjust angle and the other end inserts by position again; Detect the stability of fracture and bone adapter, successively attachment screw is screwed into outside skeleton, the anti-screw that revolves is through skeleton and bone adapter screw hole, fixing bone adapter and corresponding osseous tissue, after being screwed into, the anti-screw thread that revolves at attachment screw two ends plays pressurization, effectively reduces the problem that existing " segmental pattern " artificial prosthesis easily rotates and loosens.
Embodiment 2
The porous tantalum material that the body 1 of porous tantalum metal bone adapter described in embodiment 1 adopts utilizes chemical gaseous phase depositing process, tantalum metallic compound is reduced to tantalum metal powder, uniform deposition forms tantalum coating in graphitic carbon skeleton surface and prepares, and wherein said tantalum metallic compound is tantalic chloride; The porosity 85% of described graphitic carbon skeleton, aperture is 500 μm; The thickness of described tantalum coating is 40 ~ 60 μm.
Described porous tantalum bone adapter is prepared with the following method:
(1) by described graphitic carbon skeleton dilute hydrochloric acid etch 10min, dry up with nitrogen with after water and ethanol purge successively, insert in reative cell;
(2) be that the phosphoric carbon dust of 400 object puts into carrying shield by particle diameter, be heated to 150 DEG C, with high temperature argon (300 DEG C) for carrier gas passes into reative cell, carrier gas flux is 100ml/min, reaction chamber temperature is 1050 DEG C, and reative cell vacuum is 10Pa; Passing in reative cell with argon is while carrier gas passes into tantalic chloride powder, passes into hydrogen with 120ml/min flow, reduction reaction 4 hours, makes the tantalum metal uniform deposition being reduced into metal dust in graphitic carbon skeleton surface and its apparent gap.
The porosity of the porous tantalum bone connector body material that said method prepares is 85%, elastic modelling quantity is 10GPa, maximum compressive strength is 35MPa., wherein porosity is according to standard GB/T/T21650.1-2008, and elastic modelling quantity is for detecting according to the method described in standard GB/T/T22315-2008.
Described porous tantalum material, have hole three-dimensional communication distribution dodecahedron network structure, its structure and Grafting Cancellous Bone Bolt girder similar, there is the high tissue compatibility, osseous tissue can be induced to generate, be convenient to growing into of osseous tissue; And there is stronger biomechanical property, certain mechanical support can be provided, reach the object promoting union of fracture and reparation, filling bone defects.
In above-mentioned preparation method, if no special instructions, the experimental technique used is conventional method, and agents useful for same etc. all can chemically Reagent Company be bought.Described graphitic carbon skeleton is commercial product, can buy on the market.General employing Colophonium carries out high-temperature process as substrate, adds foam in process, thus obtains even porous dodecahedron celion skeleton.
In above-mentioned preparation method, first graphitic carbon skeleton is processed into the shape described in Fig. 1, then prepares porous tantalum bone adapter of the present invention through step (1) ~ (2).
Claims (9)
1. a porous tantalum metal bone adapter, comprises body, it is characterized in that, the two ends of described body are respectively arranged with the pulp cavity handle that can insert medullary cavity, described pulp cavity handle and this body by integral forming, and described pulp cavity handle is respectively arranged with at least one screw hole.
2. bone adapter according to claim 1, is characterized in that, the pulp cavity handle at described body two ends is respectively provided with two screw holes.
3. bone adapter according to claim 1, is characterized in that, described bone adapter also comprises the attachment screw matched with described screw hole, and the two ends of described attachment screw are provided with prevents revolving screw thread.
4. bone adapter according to claim 1, is characterized in that, described body is cylindrical, and described pulp cavity handle is conical, pulp cavity shank diameter from body phase company headquarters to ends taper.
5. bone adapter according to claim 1, is characterized in that, is 10:4 ~ 7 with the pulp cavity shank diameter of body connecting portion and the ratio of body diameter.
6. bone adapter according to claim 1, is characterized in that, the length of described pulp cavity handle and the length of body are than being 1:1 ~ 3.
7. the bone adapter according to any one of claim 1 ~ 6, it is characterized in that, the material that described bone adapter adopts utilizes chemical gaseous phase depositing process, tantalum metallic compound is reduced to tantalum metal powder, uniform deposition forms tantalum coating in graphitic carbon skeleton surface and prepares, and wherein said tantalum metallic compound is tantalic chloride, the one of fluoridizing in tantalum; The porosity >70% of described graphitic carbon skeleton, aperture is 200 ~ 600 μm; The thickness of described tantalum coating is 40 ~ 60 μm.
8. a preparation method for bone adapter as claimed in claim 7, is characterized in that, comprise the steps:
(1) by the dilute hydrochloric acid etch 10 ~ 20min of graphitic carbon skeleton described in claim 7, dry up with nitrogen with after water and ethanol purge successively, insert in reative cell;
(2) pass into process gas and hydrogen in reative cell simultaneously, at 900 ~ 1050 DEG C, under vacuum 10 ~ 15Pa condition, reaction 4-6 hour; Wherein said process gas comprises tantalum metallic compound and carrier gas, and tantalum metallic compound is put into carrying shield, is heated to 120 ~ 250 DEG C, and 300 DEG C of noble gases are that carrier gas passes into reative cell; The flow of described process gas is 80 ~ 100ml/min; The flow of described hydrogen is 100 ~ 150ml/min.
9. preparation method according to claim 8, is characterized in that, described noble gas is one or both the mixing in argon, helium.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510673087.3A CN105380731A (en) | 2015-10-15 | 2015-10-15 | Porous tantalum metal bone connector and application thereof |
| PCT/CN2016/091725 WO2017063425A1 (en) | 2015-10-15 | 2016-07-26 | Porous tantalum metal bone connector and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510673087.3A CN105380731A (en) | 2015-10-15 | 2015-10-15 | Porous tantalum metal bone connector and application thereof |
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| CN105380731A true CN105380731A (en) | 2016-03-09 |
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| CN201510673087.3A Pending CN105380731A (en) | 2015-10-15 | 2015-10-15 | Porous tantalum metal bone connector and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105662655A (en) * | 2016-03-16 | 2016-06-15 | 张黎 | Hand and foot bone defect implant |
| CN106175989A (en) * | 2016-07-01 | 2016-12-07 | 佟文 | A kind of connection prosthese for key defect |
| WO2017063425A1 (en) * | 2015-10-15 | 2017-04-20 | 赵德伟 | Porous tantalum metal bone connector and application thereof |
| CN108578018A (en) * | 2018-04-04 | 2018-09-28 | 北京市春立正达医疗器械股份有限公司 | The production method of prosthese and prosthese |
| CN109609925A (en) * | 2019-02-21 | 2019-04-12 | 苏州鑫沣电子科技有限公司 | A kind of chemical vapor deposition high-purity tantalum sputtering target material production method |
| CN111265292A (en) * | 2019-09-20 | 2020-06-12 | 上海市第六人民医院 | Broken bone aligning device |
| CN112423687A (en) * | 2018-07-10 | 2021-02-26 | 阿德勒奥尔托股份公司 | Device for promoting the formation of new bone tissue |
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| CN203107258U (en) * | 2013-01-25 | 2013-08-07 | 重庆市中山医院 | Integration type main nail of interlocking intramedullary nail |
| CN103480043A (en) * | 2013-09-26 | 2014-01-01 | 赵德伟 | Porous medical tantalum implant material and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017063425A1 (en) * | 2015-10-15 | 2017-04-20 | 赵德伟 | Porous tantalum metal bone connector and application thereof |
| CN105662655A (en) * | 2016-03-16 | 2016-06-15 | 张黎 | Hand and foot bone defect implant |
| CN106175989A (en) * | 2016-07-01 | 2016-12-07 | 佟文 | A kind of connection prosthese for key defect |
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| CN108578018A (en) * | 2018-04-04 | 2018-09-28 | 北京市春立正达医疗器械股份有限公司 | The production method of prosthese and prosthese |
| CN112423687A (en) * | 2018-07-10 | 2021-02-26 | 阿德勒奥尔托股份公司 | Device for promoting the formation of new bone tissue |
| CN109609925A (en) * | 2019-02-21 | 2019-04-12 | 苏州鑫沣电子科技有限公司 | A kind of chemical vapor deposition high-purity tantalum sputtering target material production method |
| CN111265292A (en) * | 2019-09-20 | 2020-06-12 | 上海市第六人民医院 | Broken bone aligning device |
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