CN105250060A - Capsule for stomach capacity reduction and weight reduction - Google Patents
Capsule for stomach capacity reduction and weight reduction Download PDFInfo
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- CN105250060A CN105250060A CN201510670166.9A CN201510670166A CN105250060A CN 105250060 A CN105250060 A CN 105250060A CN 201510670166 A CN201510670166 A CN 201510670166A CN 105250060 A CN105250060 A CN 105250060A
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Abstract
The invention relates to a capsule for stomach capacity reduction and weight reduction. The capsule comprises an outer capsule layer and a built-in capsule body. The capsule body is sealed; a separator layer is arranged inside the capsule body to divide the capsule body into a left cavity and a right cavity, wherein the two cavities are separated from each other; and the left cavity and the right cavity are filled with inorganic acid salt and organic acid. A micro magnetically controlled switch is arranged at the separator layer. And an air escape valve prepared by enteric-coated materials is arranged at one end of the capsule body. After a patient takes the capsule, the magnetically controlled switch is controlled remotely by a magnetic sensor; the capsule is expanded based on reaction of the inorganic acid salt with the organic acid and thus the part of stomach cavity of the patient is filled, thereby reducing the stomach capacity and realizing an effect of weight reduction. The provided capsule has the following advantages: firstly, the capsule taking is realized, the operation is simple; safety and reliability are high, the cost is low, and the capsule is easy to popularize; and secondly, on the basis of the noninvasive weight reduction method, an objective of weight reduction is achieved by changing a bad eating habit of a patient, so that side effects caused by weight reduction with drugs are eliminated, the pain of the patient due to dial control can be avoided, and the obesity degree of the patient is effectively reduced.
Description
Technical field
The present invention relates to technical field of medical instruments, specifically, is that a kind of stomach subtracts appearance slimming capsule.
Background technology
Obesity is a kind of by the multifactor complex disease caused, and it occurs relevant with the factor such as inherited genetic factors, environmental factors, social factor, psychological factor, living habits and diet structure, is interactive result between many factors.The fat epidemic diseases having become the whole world is announced as far back as WHO in 1997, obesity not only affects orthobiosis, or the important risk factor that multiple Chronic Non-Communicable Diseases (as cardiovascular disease, type ii diabetes, respiratory system disease and some cancer etc.) occurs, have a strong impact on the quality of life of people, threaten physically and mentally healthy.Obese people is subject to other people discrimination in social life and can produces strong inferiority complex to the dissatisfied of self build, and causes that homicide rate is high, marriage rate Di Deng social problem.World Health Organization's related data shows, fat has become one of great global public health problem, is more and more subject to people's attention.
Current ways of preventing obesity mainly contains diet control, physical training, Drug therapy and operative treatment, but diet control is difficult to lastingly, physical training not easily takes effect, Drug therapy has wound body.Simple conservative method of weight-reducing cannot produce a desired effect, thinks now that operation is uniquely permanently effective weight reducing treatments method.Effective method of weight-reducing mainly reaches fat-reducing object by two aspects, and one is the absorption of erstricted diet or the absorption of minimizing food, and second aspect is the consumption increasing superfluous nutrient substance.Lipposuction method is a lot, holds art, scope-peritoneoscope associating body of stomach reduces fat-reducing art, fatty skin excision, stomach wall muscular fasciae Reefing, suction lipectomy and ultrasound wave broken fat fat-reducing art etc. as peritoneoscope adjustable gastric band subtracts.Surgical treatment of obesity operation can play the object of weight reducing and fat-reducing to a certain extent, but operation all has traumatic to some extent, may bring tissue and internal organs wound, all should not reuse for a long time while fat-reducing.
" gastric water polo therapy " is a kind of very effective medical science weight reducing treatments art, its weight-losing principle utilizes gastroscope to insert in stomach in the silicon controlling the water circulation ball of unaerated, again normal saline is injected in water polo, stomach volume is reduced, comparatively early produce satietion after feed and reduce food intake, to reach the effect of fat-reducing.This method is compared with other operation method, less to patient's injury, and effectiveness, the safety of its treatment are obtained for abundant accreditation, in the extensive use of multiple country.But this method exists the shortcoming that it is difficult to overcome: one is that operating gastroscope is more complicated, and operating time is long, needs general anesthesia, therefore by professional person in operation, must also have certain anesthetic risks.Two is that operating gastroscope causes larger misery to patient, has certain damage to throat and esophagus.Recent study personnel improve prior art, developed multiple physical slimming air bag.As Chinese patent 200420032735.4, publication date discloses a kind of slimming capsule of gastric automatic inflating on February 1st, 2006, be made up of airbag body, aerogenesis chemical substance and gastric-dissolved capsule three part, after obese patient takes capsule, air bag can expand by rapid automatic inflating, increase patient's feeling of repletion, reduce gastric capacity.Chinese patent 200810300628.8, publication date on August 27th, 2008, disclose a kind of self-inflating air bag in digestive tract cavity, its utricule is closed, include at this utricule two kinds just generate gas aerogenesis thing once mixing, gastric solubleness material is banded in outside described utricule, and two kinds of described aerogenesis things are isolated in the different spaces of utricule respectively, it is simple that this Weight-reducing sac has use, mediates easy advantage.Above-mentioned patent formula all employ gastric solubleness line tying air bag, utilizes gastric solubleness line to decompose under one's belt and makes airbag aeration.But this method cannot ensure that the gastric solubleness line tying up air bag can be decomposed under one's belt completely, also likely gastric solubleness line (or decompose after) airbag apparatus in catabolic process fails inflation in time, and is discharged into intestinal and inflates just now, causes intestinal infraction.
Summary of the invention
The object of the invention is for deficiency of the prior art, provide a kind of stomach to subtract appearance slimming capsule.
Of the present invention again one object be that the purposes of above-mentioned slimming capsule is provided.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of stomach subtracts appearance slimming capsule, comprises outer capsule layer, built-in utricule; Described utricule is closed, in this utricule, be provided with separate layer, and utricule is divided into left and right two cavitys mutually completely cut off by separate layer; In described left and right two cavitys, inorganic acid salt and organic acid are housed respectively, after inorganic acid salt mixes with organic acid, generate gas; Described separate layer is provided with miniature magnetic switch; Described utricule one end is provided with the gas bleeder valve prepared by enterosoluble substance, and gas bleeder valve can not dissolve under one's belt, dissolves gradually thus discharge the gas in utricule after entering small intestinal.
Described enterosoluble substance means and is insoluble to gastric juice but can the material of disintegrate in intestinal juice.Gastric juice is acid, and small intestinal, between stomach and large intestine, comprises duodenum, jejunum and ileum.Duodenal pH is about 5.5, and the pH of jejunum is about 6.5, and the pH of distal ileum is about 7.5.Correspondingly, it is 5.0,5.2,5.4,5.6,5.8,6.0,6.2,6.4,6.6,6.8,7.0,7.2,7.4,7.6,7.8,8.0,8.2,8.4,8.6,8.8,9.0,9.2,9.4,9.6,9.8 that enterosoluble substance can be designed to PH, or the pH of about 10.0 is just solvable.Described enterosoluble substance can be cellulose acetate phthalate (CAP), HPMCP (HPMCP), polyvinyl acetate phthalate (PVAP), hydroxypropylmethyl cellulose acetate succinate (HPMCAS), cellulose acetate trimellitate, HYDROXY PROPYL METHYLCELLULOSE succinate, cellulose acetate succinate, cellulose acetate hexahydrophthalic acid ester, cellulose propionate phthalic acid ester, cellulose acetate maleate, celluloseacetate butyrate, cellulose acetate propionate, the copolymer of methacrylic acid (methylmethacrylicacid) and methyl methacrylate, acrylic acid methyl ester., the copolymer of methyl methacrylate and methacrylic acid, the copolymer (GantrezES series) of ethylene methacrylic ether and maleic anhydride, ethyl methacrylate-methyl methacrylate-chlorine trimethylammoniumethyl acrylates (chlorotrimethylammoniumethylacrylate) copolymer, fatty acid, fat, wax, Lac, ammonification Lac and cellulose acetate phthalate.The dissolution properties of above-mentioned substance is known or easily determines by experiment, can select other enteric solubility matters meeting target of the present invention after those skilled in the art know technology contents disclosed in this invention as required.
Described inorganic acid salt is sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, calcium bicarbonate or potassium bicarbonate, is preferably sodium bicarbonate; Described organic acid is citric acid, acetic acid, oxalic acid, tartaric acid, formic acid or malic acid, is preferably citric acid.
Described utricule is Fructus Canarii albi ball-type, is made up of nontoxic acidproof flexible material.
There is hemispherical projections on described utricule surface.
Described outer capsule layer is made up of gastric solubleness material.
Described miniature magnetic switch is unidirectional normally closed, and when using magnetometric sensor near magnetic switch, magnetic switch is opened.
Under unaerated state, described utricule major axis is 40mm-50mm, minor axis 20-30mm; Utricule major axis after inflation is 80mm-100mm, and minor axis is 50-70mm.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
As above arbitrary described stomach subtracts and holds slimming capsule and preparing the purposes in physics slimming apparatus.
The invention has the advantages that:
1, stomach of the present invention subtracts and holds simple to operate, the patient of slimming capsule and only need to swallow on an empty stomach uses, safe and reliable, and expense is low, be easy to popularization.
2, approximate noninvasive method of weight-reducing, reaches the object of fat-reducing, the side effect both not had weight reduction with drugs to bring by changing patient's Bad Eating Habit, turn avoid Patients' rights diet and the misery that causes, the obese degree of patient is releived greatly.
3, can not have side effect or injury to patient body, conventional capsule size is easily swallowed, and does not also have uncomfortable sensation.
4, lightweight after utricule inflation, meeting self-suspending, above stomach, more easily causes satiety.
5, one end of utricule is provided with the gas bleeder valve prepared by enterosoluble substance, can dissolve gradually thus get rid of the gas in utricule after gas bleeder valve enters small intestinal, effectively can avoid the intestinal infraction that utricule causes at little enteral inflation because of fortuitous event.
6, utricule surface is provided with multiple hemispherical projections; room is left between hemispherical projections; utricule after inflation is contacted with gastric mucosa by the hemispherical projections on surface; the contact area of the utricule after expansion and gastric mucosa can be reduced; the food be under one's belt above utricule can pass through from room; decrease utricule to stomach decompression, available protecting gastric mucosa simultaneously, alleviate the stomach upset reaction of patient.
Accompanying drawing explanation
Accompanying drawing 1 is that fat-reducing of the present invention subtracts appearance capsule structure schematic diagram.
Detailed description of the invention
Below in conjunction with detailed description of the invention, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.
The Reference numeral related in accompanying drawing and ingredient as follows:
1. the built-in utricule of outer capsule layer 2.;
The miniature magnetic switch of 21. separate layer 22.;
23. gas bleeder valve 24. hemispherical projections.
Embodiment
Please refer to Fig. 1, Fig. 1 is that stomach of the present invention subtracts appearance slimming capsule structural representation.Described stomach subtracts appearance slimming capsule and comprises outer capsule layer 1, built-in utricule 2 two parts.Described outer capsule layer 1 is column type, is made up of gastric solubleness material, and outer capsule layer 1 plays packaging, protection utricule 2, is convenient to swallow, and after capsule is swallowed and entered stomach, outer capsule layer 1 can fast decoupled under the effect of gastric acid.Described utricule 2 is Fructus Canarii albi ball-type, the preparing material and need meet following condition of utricule 2: the flexible material nontoxic, acidproof, air-tightness is good, as epoxy natural rubber, polyurethane, silica gel, latex, butyl rubber etc.Utricule 2 is for what close, and under unaerated state, the major axis of utricule 2 is 40mm-50mm, and minor axis is 20-30mm; Utricule 2 major axis after inflation is 80mm-100mm, and minor axis is 50-70mm.Separate layer 21 is provided with in utricule 2; Utricule is divided into left and right two cavitys mutually completely cut off by separate layer 21, in two cavitys, inorganic acid salt and organic acid is housed respectively; Described inorganic acid salt is selected from: sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, calcium bicarbonate or potassium bicarbonate, is preferably sodium bicarbonate; Described organic acid is selected from: citric acid, acetic acid, oxalic acid, tartaric acid, formic acid or malic acid, is preferably citric acid.Inorganic acid salt and organic acid content can carry out quantitative Analysis according to the volume size after utricule inflation.Described separate layer 21 is provided with miniature magnetic switch 22, and by the closed of magneto-dependent sensor remote control magnetic switch 22 and unlatching, one end of described utricule 2 is provided with the gas bleeder valve 23 prepared by enterosoluble substance, and gas bleeder valve 23 is prepared from by enterosoluble substance.Before use capsule of the present invention, magnetic switch 22 is always closed, guarantees that two cavitys in left and right are in state of isolation all the time.When patient uses warm water stomach of the present invention of swallowing fast to subtract appearance slimming capsule, enter after stomach until capsule, doctor by magneto-dependent sensor near patient, magnetic switch 22 is converted to opening by closure state under the influence of a magnetic field, two, the left and right cavity of utricule 2 is interconnected, after inorganic acid salt in cavity mixes with organic acid, chemical reaction occurs, produce a large amount of gas, full utricule 2 makes it expand.Utricule 2 is inflated rear expansion and is become large, fills patient part's gastral cavity, stomach volume is reduced, comparatively early produce satietion and reduce food intake, reach the effect of fat-reducing after patients diet.
It should be noted that, herein, be Fructus Canarii albi ball-type after described utricule 2 inflation, while the utricule 2 after this design can make expansion fills gastral cavity, can not gastric mucosa be oppressed, reduce the stomach upset reaction of patient.Described utricule 2 surface is provided with multiple hemispherical projections; utricule 2 after inflation is contacted with gastric mucosa by the hemispherical projections 24 on surface; this design can reduce the contact area of the utricule after expansion 2 and gastric mucosa; be convenient to the top that utricule 2 swims in stomach; so no matter how the position of utricule changes; all can not be close to gastric mucosa; room is left between hemispherical projections; the food be under one's belt above utricule can pass through from room; decrease utricule to stomach decompression, available protecting gastric mucosa simultaneously.One end of described utricule 2 is provided with the gas bleeder valve 23 prepared by enterosoluble substance, and gas bleeder valve 23 can not dissolve under one's belt, and can dissolve gradually thus get rid of the gas in utricule 2 after entering small intestinal.After utricule 2 unaerated is discharged into intestinal completely, gas bleeder valve 23 dissolves gradually thus gets rid of the gas in utricule 2, the generation that this design can effectively avoid intestinal to block in small intestinal.
Stomach of the present invention subtracts the using method holding slimming capsule:
Patient uses warm water stomach of the present invention of swallowing fast to subtract appearance slimming capsule under the guidance of doctor, enter after stomach until capsule, doctor by magneto-dependent sensor near patient, magnetic switch 22 is converted to opening by closure state under the influence of a magnetic field, two, the left and right cavity of utricule 2 is interconnected, after inorganic acid salt in cavity mixes with organic acid, chemical reaction occurs, produce a large amount of gas, full utricule 2 makes it expand.Utricule 2 is inflated rear expansion and is become large, fills patient part's gastral cavity, stomach volume is reduced, comparatively early produce satietion and reduce food intake, reach the effect of fat-reducing after patients diet.When needs take out, by gastroscope, conduit is inserted gastric, picked up by utricule by negative pressure, conduit wiry is housed by the gas sucking-off in utricule in addition with one, the utricule after reducing is discharged with stool by digestion.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (9)
1. stomach subtracts an appearance slimming capsule, it is characterized in that, comprises outer capsule layer, built-in utricule; Described utricule is closed, in this utricule, be provided with separate layer, and utricule is divided into left and right two cavitys mutually completely cut off by separate layer; In described left and right two cavitys, inorganic acid salt and organic acid are housed respectively, after inorganic acid salt mixes with organic acid, generate gas; Described separate layer is provided with miniature magnetic switch; Described utricule one end is provided with the gas bleeder valve prepared by enterosoluble substance, and gas bleeder valve can not dissolve under one's belt, dissolves gradually thus discharge the gas in utricule after entering small intestinal.
2. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, described inorganic acid salt is sodium carbonate, potassium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, calcium bicarbonate or potassium bicarbonate; Described organic acid is citric acid, acetic acid, oxalic acid, tartaric acid, formic acid or malic acid.
3. stomach according to claim 2 subtracts appearance slimming capsule, it is characterized in that, described inorganic acid salt is sodium bicarbonate; Described organic acid is citric acid.
4. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, described utricule is Fructus Canarii albi ball-type, is made up of nontoxic acidproof flexible material.
5. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, there is hemispherical projections on described utricule surface.
6. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, described outer capsule layer is made up of gastric solubleness material.
7. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, described miniature magnetic switch is unidirectional normally closed, and when using magnetometric sensor near magnetic switch, magnetic switch is opened.
8. stomach according to claim 1 subtracts appearance slimming capsule, it is characterized in that, under unaerated state, described utricule major axis is 40mm-50mm, minor axis 20-30mm; Utricule major axis after inflation is 80mm-100mm, and minor axis is 50-70mm.
9. the arbitrary described stomach of claim 1-8 subtracts and holds slimming capsule and preparing the purposes in physics slimming apparatus.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106038474A (en) * | 2016-06-23 | 2016-10-26 | 冯世英 | Methods for making and using three-component weight-reducing pill |
| WO2017034478A1 (en) * | 2015-08-21 | 2017-03-02 | Nanyang Technological University | Intragastric device for weight management |
| CN106511372A (en) * | 2016-11-23 | 2017-03-22 | 邹立新 | Intragastric self-expanding weight-reducing drug |
| CN108420579A (en) * | 2018-03-29 | 2018-08-21 | 郑仕诚 | Weight-reducing sac in a kind of stomach with remote control valve |
| CN110584854A (en) * | 2019-09-29 | 2019-12-20 | 上海理工大学 | Totally-enclosed weight-losing capsule with magnetic control contraction function |
| CN110613541A (en) * | 2019-09-29 | 2019-12-27 | 上海理工大学 | Magnetic control type weight-losing capsule and assembly thereof |
| CN110664526A (en) * | 2019-09-29 | 2020-01-10 | 上海理工大学 | Magnetic control weight-losing capsule with side air bag |
| CN116602807A (en) * | 2023-05-22 | 2023-08-18 | 张勤生 | Capsule type self-produced gas stomach volume-reducing weight-reducing air bag |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017034478A1 (en) * | 2015-08-21 | 2017-03-02 | Nanyang Technological University | Intragastric device for weight management |
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| CN108420579A (en) * | 2018-03-29 | 2018-08-21 | 郑仕诚 | Weight-reducing sac in a kind of stomach with remote control valve |
| CN110584854A (en) * | 2019-09-29 | 2019-12-20 | 上海理工大学 | Totally-enclosed weight-losing capsule with magnetic control contraction function |
| CN110613541A (en) * | 2019-09-29 | 2019-12-27 | 上海理工大学 | Magnetic control type weight-losing capsule and assembly thereof |
| CN110664526A (en) * | 2019-09-29 | 2020-01-10 | 上海理工大学 | Magnetic control weight-losing capsule with side air bag |
| CN116602807A (en) * | 2023-05-22 | 2023-08-18 | 张勤生 | Capsule type self-produced gas stomach volume-reducing weight-reducing air bag |
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