CN104068865A - Oxyhemoglobin saturation measuring method and portable device - Google Patents
Oxyhemoglobin saturation measuring method and portable device Download PDFInfo
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- CN104068865A CN104068865A CN201410168663.4A CN201410168663A CN104068865A CN 104068865 A CN104068865 A CN 104068865A CN 201410168663 A CN201410168663 A CN 201410168663A CN 104068865 A CN104068865 A CN 104068865A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
Abstract
The invention discloses an oxyhemoglobin saturation measuring method. The oxyhemoglobin saturation measuring method comprises sending first measuring light, second measuring light and reference light to body surface skin of a measured object and receiving reflected light of the first measuring light, the second measuring light and the reference light; obtaining a first difference value and a second difference value, wherein the first difference value is the difference of rates of light intensity change of the first reflected light and the reference reflected light and the second difference value is the difference of rates of light intensity change of the reference reflected light and the second reflected light; obtaining a ratio x of the first difference value and the second difference value through calculation and calculating the oxyhemoglobin saturation y according to the ratio x. Correspondingly, the invention also provides an oxyhemoglobin saturation measuring portable device. According to the oxyhemoglobin saturation measuring method and portable device, accurate measurement of the oxyhemoglobin saturation can be achieved in real time.
Description
Technical field
The invention belongs to physiological parameter measurement field, relate in particular to a kind of method and portable set of measuring blood oxygen saturation.
Background technology
Oxygen is the important element that maintains human normal physiological activity, and airborne oxygen enters blood after exchanging by human lung, is combined in and in hemoglobin, is sent to whole body.Hemoglobin is made up of four chains, two α chains and two β chains, and each chain has a ring-type haemachrome that comprises an iron atom.Combination with oxygen is on iron atom, by blood transportation.Every gram of hemoglobin can be in conjunction with the oxygen of 1.34ml, is 70 times of blood plasma dissolved oxygen amount.
With HbO2 Oxyhemoglobin (HbO
2) and reduced hemoglobin be basic blood oxygen saturation (SO
2) characterize the state of human body Oxygen cycle, be the important parameter that judges human body respiration and blood circulation.Blood oxygen saturation is the percentage ratio that is accounted for whole combinative hemoglobin (Hb) capacity in blood by the capacity of the HbO2 Oxyhemoglobin of oxygen combination, the i.e. concentration of blood oxygen in blood.The blood oxygen saturation of normal human's arterial blood is 98%, and venous blood is 75%.Generally recognize SpO
2normally should be not less than 94%, be for hypoxgia below 94%.
The harm of anoxia is relevant with degree of oxygen deficiency, generation speed and persistent period.What when hypoxia, first occur is that compensatory heart rate accelerates, and heartbeat and cardiac output increase, and blood circulation is with the deficiency of the compensatory oxygen content of hyperkinetic state.Produce blood flow reallocation, brain and coronary vasodilator selectivity expand to ensure that enough blood supplies simultaneously.Severe hypoxia, under endocardium, lactic acid is piled up, ATP (adenosine triphosphate, adenosine triphosphate) synthetic reduction, produce myocardiac inhibition, cause bradycardia, premature beat, blood pressure drops and cardiac output reduce, and the chamber of the appearance arrhythmia and even stop fighting such as quiver.Therefore extremely important for the Real-Time Monitoring of blood oxygen saturation.
Detect the damage that human body is caused for fear of blood sampling, main employing can not cause the noinvasive detection method of damage to detect blood oxygen saturation to human body now.Noinvasive blood oxygen saturation detects and is divided into transmission-type and reflective two kinds of methods.Wherein, transmission-type method is analyzed blood oxygen saturation by obtaining through the transillumination of tissue, because optical signal transmissive is stronger, measures accuracy rate high, and therefore the method has obtained extensive use at present clinically.But transmission-type method is applicable to being applied in the place that skin is thinner, so that therefore optical transmission limits to some extent to application site.Reflective method is obtained the light intensity signal being reflected by tissue, thereby its probe is not subject to the restriction of riding position, has more wide application prospect.But not high by the method accuracy rate of reflective measurement blood oxygen saturation at present, error is larger.
Summary of the invention
In order to solve, the method precision of existing reflective measurement blood oxygen saturation is low, the problem of effective rate variance, the invention provides a kind of method of measuring blood oxygen saturation.
According to an aspect of the present invention, provide a kind of method of measuring blood oxygen saturation, wherein, described method comprises step:
A) send first to the skin surface of measured object and measure light, second measures light and reference light, and receives the reflected light of described the first measurement light, described the second measurement light and described reference light;
B) obtain the first difference and the second difference, wherein,
Described the first difference is the poor of the first reflected light and the catoptrical light intensity rate of change of reference;
Described the second difference is poor with reference to reflected light and the second catoptrical light intensity rate of change;
C) obtain the ratio x of described the first difference and described the second difference by calculating, and according to described ratio x, calculate blood oxygen saturation y.
According to a specific embodiment of the present invention, described step is further c):
Obtain the ratio x of described the first difference and described the second difference by calculating, and according to described ratio x, utilize formula y=nx+m, calculate blood oxygen saturation y; Wherein, n > 0; 0 < m < 100.
According to another detailed description of the invention of the present invention,
Described the first measurement light wavelength is 660nm ± 3nm;
Described the second measurement light wavelength is 940nm ± 10nm;
Described is 820 ± 10nm with reference to light wavelength.
According to another detailed description of the invention of the present invention, described skin surface is the corresponding wrist skin surface of the radial artery of described measured object.
According to another aspect of the present invention, provide a kind of portable set of measuring blood oxygen saturation, wherein, described portable set comprises: light emission and Optical Receivers, computing module and processing module;
Described light emission and receiver module, send first for the skin surface to measured object and measure light, and second measures light and reference light, and receive the reflected light of described the first measurement light, described the second measurement light and described reference light;
Computing module, for calculating and obtain the first difference and the second difference, wherein, described the first difference is the poor of the first reflected light and the catoptrical light intensity rate of change of reference,
Described the second difference is poor with reference to reflected light light intensity and the second catoptrical light intensity rate of change;
Processing module, for calculating and obtain the ratio x of described the first difference and described the second difference, and according to described ratio x, calculates blood oxygen saturation y.
According to a specific embodiment of the present invention, described processing module, according to described ratio x, calculates blood oxygen saturation y, is specially: according to described ratio x, utilize formula y=nx+m, calculate blood oxygen saturation y;
Wherein, n > 0; 0 < m < 100.
According to another detailed description of the invention of the present invention,
Described the first measurement light wavelength is 660nm ± 3nm;
Described the second measurement light wavelength is 940nm ± 10nm;
Described is 820nm ± 10nm with reference to light wavelength.
According to another detailed description of the invention of the present invention, described skin surface is the corresponding wrist skin surface of the radial artery of described measured object.
According to another detailed description of the invention of the present invention, described portable set has wrist formula and wears structure.
According to another detailed description of the invention of the present invention, this portable set also comprises:
Display module, for showing described blood oxygen saturation.
First the present invention sends and measures light and reference light to the skin surface of measurand, receives afterwards the reflected light of measuring light and reference light, and utilization calculates the blood oxygen saturation of measurand through the light intensity rate of change of each Shu Guang of reflection.Adopt the method for reflection to obtain the light intensity signal by the test position reflection of measurand, light intensity signal is strong, thereby test probe is not subject to the restriction of riding position, more flexible.In test process, add reference light, can effectively remove the internal absorbance of measurand to the absorption of test light, made measurement result more accurate.
Brief description of the drawings
By reading the detailed description that non-limiting example is done of doing with reference to the following drawings, it is more obvious that other features, objects and advantages of the present invention will become:
Figure 1 shows that according to the schematic flow sheet of a detailed description of the invention of a kind of method of measuring blood oxygen saturation provided by the invention;
Figure 2 shows that the graph of a relation of wavelength and absorptance;
Figure 3 shows that according to the structural representation of a kind of portable set of measuring blood oxygen saturation provided by the invention.
In accompanying drawing, same or analogous Reference numeral represents same or analogous parts.
Detailed description of the invention
Disclosing below provides many different embodiment or example to be used for realizing different structure of the present invention.Of the present invention open in order to simplify, hereinafter the parts to specific examples and setting are described.In addition, the present invention can be in different examples repeat reference numerals and/or letter.This repetition is in order to simplify and object clearly, itself do not indicate the relation between discussed various embodiment and/or setting.It should be noted that illustrated parts are not necessarily drawn in proportion in the accompanying drawings.The present invention has omitted the description of known assemblies and treatment technology and technique to avoid unnecessarily limiting the present invention.
With reference to figure 1, Figure 1 shows that according to the schematic flow sheet of a detailed description of the invention of a kind of method of measuring blood oxygen saturation provided by the invention.
Oxygen saturation measurement changes with arteriopalmus the absorbtivity of light based on arterial blood.In the time that transmission region arteries is beaten, arterial blood will change the absorbtivity of light thereupon, and its hetero-organizations such as skin, muscle, skeleton and venous blood are constant to the absorption of light.Particularly, the main applicable object of the method for measurement blood oxygen saturation provided by the invention is the mankind, and therefore described measured object mainly refers to the mankind that need to carry out oxygen saturation measurement in this article.The method that it will be appreciated by those skilled in the art that measurement blood oxygen saturation provided by the invention can also be applied to for having the measurement of the mammiferous blood oxygen saturation of same or similar physiological property with the mankind.
Step S101, sends first to the skin surface of measured object and measures light, and second measures light and reference light, and receives the reflected light of described the first measurement light, described the second measurement light and described reference light.
The reflection method for measuring blood oxygen saturation that the present invention adopts, concrete principle is to send light wave to tissue, this light wave generates reflected light after tissue reflection, then receive this reflected light and analyze the physiological situation of the human body that this reflected light reflects, thereby reach the object of measuring human body blood oxygen saturation.
With reference to figure 2, a little less than the absworption peak of red light district (600nm～700nm) HbO2 Oxyhemoglobin.A little less than the absworption peak of ultrared (850nm～1000nm) reduced hemoglobin.Transmission equates with the light intensity rate of change that reflection causes, is directly proportional to absorptance.Therefore, preferred, described the first measurement light wavelength is 660nm ± 3nm, for example: 657nm, 660nm or 663nm.Preferably, described the second measurement light wavelength is 940nm ± 10nm, for example: 930nm, 940nm or 950nm.
In order to eliminate error, in measuring process, increase three-beam as with reference to light.Under three beams light wavelength, HbO2 Oxyhemoglobin is consistent to absorptivity with reduced hemoglobin, can get rid of the interference that human body native mode changes light intensity.Preferably, described is 820 ± 10nm with reference to light wavelength, for example: 810nm, 820nm or 830nm.
Preferably, the corresponding wrist skin surface of radial artery that above-mentioned skin surface is measured object.
The transmitting that two bundles are measured light and a branch of reference light can adopt three different laser instrument to realize or adopt integrated laser instrument to realize.In addition, transmitting and receiving of light can also adopt photoelectric sensor to realize, and for example, can realize with NJL5501R chip, and this chip is a kind of photoelectric sensor that can produce HONGGUANG and infrared light.
Step S102, obtains the first difference and the second difference, and wherein, described the first difference is the poor of the first reflected light and the catoptrical light intensity rate of change of reference; Described the second difference is poor with reference to reflected light and the second catoptrical light intensity rate of change.Be appreciated that the first reflected light is the first measurement reflection of light light; The second reflected light is the second measurement reflection of light light; It is the reflected light of reference light with reference to reflected light.
Above-mentioned computational process need to be by analog-digital chip or equipment by the first reflected light, the second reflected light and convert digital signal to reference to catoptrical optical signal.The chip that can realize digital-to-analogue conversion has a variety of, if and adopt NJL5501R chip to realize light emission and light-receiving in step S101, owing to having comprised the hardware configuration of realizing digital-to-analogue conversion in NJL5501R chip, do not need additionally to increase chip or equipment is realized digital-to-analogue conversion.
After conversion, the first catoptrical light intensity rate of change is designated as to a, is designated as b with reference to catoptrical light intensity rate of change, the second catoptrical light intensity rate of change is designated as c.The first difference is b-a, and the second difference is c-b.
Step S103, obtains the ratio x of described the first difference and described the second difference, and according to described ratio x, calculates blood oxygen saturation y by calculating.Preferably, utilize formula y=nx+m, calculate blood oxygen saturation; Wherein, n > 0; 0 < m < 100.Can find out from the description of step S102, wherein ratio x=(b-a)/(c-b).Obtain blood oxygen saturation y according to ratio x, can adopt single-chip microcomputer to realize.In prior art, there is multiple single-chip microcomputer can realize the calculating of digital signal, generate physiological parameter, for example: MK20DN512VLK10 chip.Be appreciated that in the present invention, this physiological parameter refers to blood oxygen saturation y, blood oxygen saturation y=nx+m.
Wherein, n > 0, for example, can value be 1,3,5 etc.; 0 < m < 100 for example, can value be 2,40,57 etc.
With reference to figure 3, Figure 3 shows that according to the structural representation of a kind of portable set of measuring blood oxygen saturation provided by the invention.
Described portable set 20 comprises: light emission and Optical Receivers 21, computing module 21 and processing module 22.
Described light emission and receiver module 21, send the first measurement light for the skin surface 10 to measured object, and second measures light and reference light, and receive the reflected light of described the first measurement light, described the second measurement light and described reference light.Preferably, the corresponding wrist skin surface of radial artery that the skin surface 10 of measurand is measured object.
Preferably, described the first measurement light wavelength is 660nm ± 3nm, for example: 657nm, 660nm or 663nm.Preferably, described the second measurement light wavelength is 940nm ± 10nm, for example: 930nm, 940nm or 950nm.
In order to eliminate error, in measuring process, increase three-beam as with reference to light.Under three beams light wavelength, HbO2 Oxyhemoglobin is consistent to absorptivity with reduced hemoglobin, can get rid of the interference that human body native mode changes light intensity.Preferably, described is 820 ± 10nm with reference to light wavelength, for example: 810nm, 820nm or 830nm.
Preferably, light emission and receiver module 21 are photoelectric sensor, for example, NJL5501R chip, this chip is a kind of photoelectric sensor that can produce HONGGUANG and infrared light.
Computing module 22, for calculating and obtain the first difference and the second difference, wherein, what described the first difference was the first reflected light with reference to catoptrical light intensity rate of change is poor, and described the second difference is described poor with reference to reflected light and the second catoptrical light intensity rate of change.The first reflected light is the utilizing emitted light of the first measurement light; The second reflected light is the utilizing emitted light of the second measurement light; It is the reflected light of reference light with reference to reflected light.
Computing module 22 can be chip or the equipment that can realize digital-to-analogue conversion, for example NJL5501R chip.In NJL5501R chip, there is the hardware configuration that can realize digital-to-analogue conversion.After conversion, the first catoptrical light intensity rate of change is designated as to a, is designated as b with reference to catoptrical light intensity rate of change, the second catoptrical light intensity rate of change is designated as c.The first difference is b-a, and the second difference is c-b.
Processing module 23, for calculating and obtain the ratio x of described the first difference and described the second difference, and according to described ratio x, calculates blood oxygen saturation y.Preferably, utilize formula y=nx+m, calculate blood oxygen saturation; Wherein n > 0; 0 < m < 100.Ratio x=(b-a)/(c-b), blood oxygen saturation y=y=nx+m.Wherein, n > 0, for example, can value be 1,3,5 etc.; 0 < m < 100 for example, can value be 2,40,57 etc.
Obtain blood oxygen saturation y according to ratio x, can adopt single-chip microcomputer to realize, therefore processing module 23 can be that single-chip microcomputer or other can be realized the embedded device that digital signal calculates.Preferably, described processing module 23 is MK20DN512VLK10 chips.
In addition, above-mentioned computing module 22 and processing module 23 can also realize as CPU by special calculator or application specific processor.
In order to meet the demand of measuring in real time blood oxygen saturation; this portable set 20 need to carry at any time; and to there is tremulous pulse below the skin being adjacent at it; in addition; can not have influence on because carrying this portable set 20 normal activity of measurand; therefore preferred, described portable set 20 has wrist formula and wears structure.
Preferably, this portable set 20 also comprises: display module, and for showing described blood oxygen saturation, for carrier provides real-time blood oxygen saturation numerical value.In addition, this display module can also displaying time etc. conventional parameter.
Adopt the method for measurement blood oxygen saturation provided by the invention and use portable set provided by the invention can measure accurately and real-time the blood oxygen saturation of measurand by reflective method.
Although describe in detail about example embodiment and advantage thereof, be to be understood that the protection domain in the case of not departing from spirit of the present invention and claims restriction, can carry out various variations, substitutions and modifications to these embodiment.For other examples, those of ordinary skill in the art should easily understand in keeping in protection domain of the present invention, and the order of processing step can change.
In addition, range of application of the present invention is not limited to technique, mechanism, manufacture, material composition, means, method and the step of the specific embodiment of describing in description.From disclosure of the present invention, to easily understand as those of ordinary skill in the art, for had or be about at present technique, mechanism, manufacture, material composition, means, method or the step developed later, wherein they carry out identical function or the identical result of acquisition cardinal principle of corresponding embodiment cardinal principle of describing with the present invention, can apply them according to the present invention.Therefore, claims of the present invention are intended to these technique, mechanism, manufacture, material composition, means, method or step to be included in its protection domain.
Claims (10)
1. measure a method for blood oxygen saturation, wherein, described method comprises step:
A) send first to the skin surface of measured object and measure light, second measures light and reference light, and receives the reflected light of described the first measurement light, described the second measurement light and described reference light;
B) obtain the first difference and the second difference, wherein,
Described the first difference is the poor of the first reflected light and the catoptrical light intensity rate of change of reference;
Described the second difference is poor with reference to reflected light and the second catoptrical light intensity rate of change;
C) obtain the ratio x of described the first difference and described the second difference by calculating, and according to described ratio x, calculate blood oxygen saturation y.
2. method according to claim 1, wherein, described step is further c):
Obtain the ratio x of described the first difference and described the second difference by calculating, and according to described ratio x, utilize formula y=nx+m, calculate blood oxygen saturation y;
Wherein, n > 0; 0 < m < 100.
3. method according to claim 1, wherein,
Described the first measurement light wavelength is 660nm ± 3nm;
Described the second measurement light wavelength is 940nm ± 10nm;
Described is 820 ± 10nm with reference to light wavelength.
4. method according to claim 1, wherein, described skin surface is the corresponding wrist skin surface of the radial artery of described measured object.
5. measure a portable set for blood oxygen saturation, wherein, described portable set comprises: light emission and Optical Receivers, computing module and processing module;
Described light emission and receiver module, send first for the skin surface to measured object and measure light, and second measures light and reference light, and receive the reflected light of described the first measurement light, described the second measurement light and described reference light;
Computing module, for calculating and obtain the first difference and the second difference, wherein, described the first difference is the poor of the first reflected light and the catoptrical light intensity rate of change of reference,
Described the second difference is described poor with reference to reflected light and the second catoptrical light intensity rate of change;
Processing module, for calculating and obtain the ratio x of described the first difference and described the second difference, and according to described ratio x, calculates blood oxygen saturation y.
6. portable set according to claim 5, wherein, described processing module, according to described ratio x, calculates blood oxygen saturation y, is specially: according to described ratio x, utilize formula y=nx+m, calculate blood oxygen saturation y;
Wherein, n > 0; 0 < m < 100.
7. portable set according to claim 5, wherein,
Described the first measurement light wavelength is 660nm ± 3nm;
Described the second measurement light wavelength is 940nm ± 10nm;
Described is 820nm ± 10nm with reference to light wavelength.
8. portable set according to claim 5, wherein, described skin surface is the corresponding wrist skin surface of the radial artery of described measured object.
9. portable set according to claim 5, wherein, described portable set has wrist formula and wears structure.
10. portable set according to claim 5, wherein, this portable set also comprises:
Display module, for showing described blood oxygen saturation.
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| CN201410168663.4A CN104068865B (en) | 2014-04-24 | 2014-04-24 | A kind of method and portable set for measuring blood oxygen saturation |
| PCT/CN2015/070723 WO2015161687A1 (en) | 2014-04-24 | 2015-01-15 | Method for measuring blood oxygen saturation and portable device |
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| CN201410168663.4A CN104068865B (en) | 2014-04-24 | 2014-04-24 | A kind of method and portable set for measuring blood oxygen saturation |
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| CN106512160B (en) * | 2016-10-14 | 2019-05-17 | 深圳市理邦精密仪器股份有限公司 | The determination method and device of oxygen transportation parameters |
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| CN104068865B (en) | 2017-05-31 |
| WO2015161687A1 (en) | 2015-10-29 |
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