CN103959070B - 组合试剂条 - Google Patents

组合试剂条 Download PDF

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CN103959070B
CN103959070B CN201280058922.7A CN201280058922A CN103959070B CN 103959070 B CN103959070 B CN 103959070B CN 201280058922 A CN201280058922 A CN 201280058922A CN 103959070 B CN103959070 B CN 103959070B
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pipette
liquid relief
aperture
core bore
relief tube
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CN103959070A (zh
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A·D·伦茨
D·利文斯顿
A·B·斯蒂尔
R·圣皮埃尔
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Becton Dickinson and Co
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00—Additional constructional details
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure

Abstract

本文所公开的实施例涉及用于保持和运送在生物和/或化学测定的自动化样品制备和/或处理中所使用的试剂和材料的组合试剂条。

Description

组合试剂条
相关申请的交叉引用
本申请要求2011年9月30日提交名称为“UNITIZED REAGENT STRIP”的美国临时申请序列号No.61/541991的优先权，其全部内容通过引用的方式以其整体并入本文。
技术领域
本文描述的技术一般涉及试剂和一次性用品的保持器，例如可用于运送试剂和通过试剂在例如自动化样品制备/处理装置中实施处理操作。
背景技术
诊断测定和高通量筛选的自动化已变得越来越普遍，并且已开发出一些装置，用以满足对多个样品的快速、敏感和一致性分析的不断增长的需要。例如，近年来，已开发出例如用于核酸测定的样品制备和处理的一体化装置。
许多重要的测定要求例如核酸、蛋白质等不同的组分与临床和/或环境样品的分离。将核酸、蛋白质或感兴趣的其他分析物与临床或环境样品分离将会是费时和费力的。样品的手工制备也受到因人为误差和不准确所致的更多变化。若干变量影响了样品制备的一致性和准确性，其通常涉及若干试剂和需要多次转移(例如，移液)操作。通常，所需的试剂具有足够的品种，它们通常需要不同于彼此的处理并且可从不同的供应商购得。这样，不同供应商和许多特定试剂之间的变化，以及一个或许多个体对不同试剂的不同处理可能导致测定波动。其次，多次移液操作引入了例如样品间和样品内的交叉污染的可能性(例如，在单一样品的不同制备和/或处理步骤期间所使用的试剂)。
需要一种并行实施大量样品的制备和处理的方法和装置，并且该方法和装置将测定间变异性减至最小。所期望的是，该方法和装置将最大程度地减少用户对制备和处理过程中所使用的试剂和/或一次性用品的操作，从而实现高效的样品处理和最大程度地减少污染和不精确，这样将维持灵活性。
所包含的本文背景技术的讨论用于解释本文所描述的本发明的背景。这不应被看作是承认所提及的任何材料在任何权利要求的优先权日已被公布、公知或是公知常识的一部分。
发明内容
本文提供的是组合试剂条和组合试剂条的使用方法。在一个方面中，提供的是组合试剂条，其包括：具有顶侧和底侧的条状物，包括：包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述移液管端头孔口的每个包括条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围第一和第二移液管端头的长度；处理管；以及接收器，其包括穿过试剂条的开口，其中所述接收器被配置成接收试剂管。
在另一个方面中，本发明提供了检测组合试剂条的移液管护套内存在或不存在移液管端头的方法，包括：具有顶侧和底侧的条状物，包括：包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述第一和第二移液管端头孔口的每个包括条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，其中所述第一和第二移液管护套的每个被配置成分别大体上包围第一和第二移液管端头的长度；处理管；以及接收器，其包括穿过试剂条的开口，其中所述接收器被配置成接收试剂管，其中所述第一移液管护套包括孔口对，所述孔口对包括延伸穿过第一移液管护套的侧壁的第一芯孔(cored hole)和第二芯孔；其中第一和第二芯孔位于第一移液管护套侧壁的相对侧上，并且被设置在距第一移液管端头孔口沿第一移液管护套长度的相同距离处；提供穿过所述移液管护套孔口对的第一芯孔的光束；以及检测所述光束是否穿过所述第一移液管护套孔口对的所述第二芯孔无阻退出，其中所述光束穿过所述第一移液管护套的所述第二芯孔的无阻退出指示了移液管护套内不存在移液管端头，其中所述光束穿过所述第二芯孔受阻退出指示了所述第一移液管护套内存在移液管端头。
在另一个方面中，本发明提供了测定组合试剂条的移液管护套内的移液管端头长度的方法，包括：提供组合试剂条，其包括：具有顶侧和底侧的条状物，所述条状物包括：处理管；接收器，其包括穿过试剂条的开口，其中所述接收器被配置成接收试剂管；第一和第二移液管护套，每个所述移液管护套分别包括：第一和第二移液管端头孔口，其每个包括条状物顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围第一和第二移液管端头的长度；所述第一移液管护套内的顶部移液管护套孔口对和底部移液管护套孔口对，所述顶部和底部孔口对每个均包括延伸穿过第一移液管护套的侧壁的第一芯孔和第二芯孔，其中所述顶部和底部移液管护套孔口对的第一和第二芯孔位于第一移液管护套的相对侧上，并且被设置在距第一移液管端头孔口沿第一移液管护套长度的相同距离处，其中所述顶部移液管护套孔口对比所述底部移液管护套孔口对位于更接近第一移液管端头孔口处；提供穿过所述顶部移液管护套孔口对的所述第一芯孔的光束；提供穿过所述底部移液管护套孔口对的所述第一芯孔的光束；检测所述光束是否在穿过所述顶部移液管护套孔口对的所述第二芯孔时受阻；以及检测所述光束是否在穿过所述第一移液管护套孔口对的所述底部芯孔时受阻，其中所述光束穿过所述顶部孔口对的第二芯孔受阻以及所述光束穿过所述底部移液管护套孔口对的第二芯孔指示了所述第一移液管护套内的移液管端头在被插入第一移液管护套内时具有没有向下延伸至底部移液管护套孔口对的长度。
在另一个方面中，提供了确定组合试剂条的移液管护套内的移液管端头长度的方法，包括：提供组合试剂条，其包括：具有顶侧和底侧的条状物，所述条状物包括：处理管；接收器，其包括穿过试剂条的开口，其中所述接收器被配置成接收试剂管；第一和第二移液管护套，每个所述移液管护套分别包括：第一和第二移液管端头孔口，其每个包括条状物顶侧上的独立开口，以及其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围第一和第二移液管端头的长度；所述第一移液管护套内的顶部移液管护套孔口对和底部移液管护套孔口对，所述顶部和底部孔口对每个均包括延伸穿过第一移液管护套的侧壁的第一芯孔和第二芯孔，其中所述顶部和底部移液管护套孔口对的第一和第二芯孔位于第一移液管护套的相对侧上，并且被设置在距第一移液管端头孔口沿第一移液管护套长度的相同距离处，并且其中所述顶部移液管护套孔口对比所述底部移液管护套孔口对位于更接近第一移液管端头孔口处；提供穿过所述顶部移液管护套孔口对的所述第一芯孔的光束；提供穿过所述底部移液管护套孔口对的所述第一芯孔的光束；检测所述光束是否在穿过所述顶部移液管护套孔口对的所述底部芯孔时受阻；以及检测所述光束是否在穿过所述第一移液管护套孔口对的所述底部芯孔时受阻，其中所述光束穿过所述顶部孔口对的第二芯孔受阻以及所述光束穿过所述底部移液管护套孔口对的第二芯孔指示了所述移液管护套内的移液管端头在被插入至移液管护套内时具有没有向下延伸至底部移液管护套孔口对的长度。
在又一个方面中，本发明提供了确定组合试剂条的移液管护套内的移液管端头长度的方法，包括：提供组合试剂条，其包括：具有顶侧和底侧的条状物，所述条状物包括：处理管；接收器，其包括穿过试剂条的开口，其中所述接收器被配置成接收试剂管；第一和第二移液管护套，每个分别包括：第一和第二移液管端头孔口，其每个包括条状物顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套内，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围第一和第二移液管端头的长度；所述第一移液管护套内的顶部芯孔和底部芯孔，所述顶部和底部芯孔中的每个延伸穿过移液管护套的侧壁，其中所述顶部芯孔比所述底部芯孔位于更接近第一移液管端头孔口处，确定移液管端头在所述第一移液管护套内是否从第一移液管端头孔口延伸至第一芯孔的距离，以及确定移液管端头在所述第一移液管护套内是否从第一移液管端头孔口延伸至第二芯孔的距离。
附图说明
参考附图详细描述了本文所提供的一个或多个不同实施例。所提供的附图仅用于说明的目的，并且仅描绘了本发明的典型或示例性实施例。提供这些附图是为了促进读者对本发明的理解，而不应视为是对本发明的广度、范围或适用性的限制。应当指出的是，为了清楚和便于说明，这些附图未必按比例绘制。
本文所包含的一些附图示出了来自不同视角的本发明的各种实施例。虽然随附的描述性文字可将这些视图称为“俯视图”、“仰视图”或“侧示图”，但此类指代仅是描述性的，并不暗示或要求本发明按特定的空间取向实现或使用，除非另有明确说明。
参考以下具体实施方式和附图，将更好地理解本文所公开的各种实施例的这些和其他特征和优点，其中相同数字指代相同部件，其中：
图1A是根据本文所述的试剂条的透视图。
图1B是根据本文所述的试剂条的透视图，其中试剂管(160)示出与试剂条分开并且插入试剂条内。
图1C是沿图1A的截面A-A的处理管的剖面图。
图1D是沿图1A的截面B-B的试剂管140的剖面图。
图1E是沿图1A的截面C-C的移液管护套的剖面图。
图1F是图1A的试剂条的俯视图。
图1G是图1A的试剂条的仰视图。
图1H是图1A的试剂条的一个实施例的剖面图。
图2A是根据本文所述的试剂条的透视图。
图2B是图2A的试剂条的俯视图。
图2C是图2A的试剂条的仰视图。
图3是根据本文所述的试剂条的平面图。
图4A-图4E示出结合薄片层的移液操作的顺序。
图5A-图5B示出薄片层的实施例。
具体实施方式
本文所述实施例提供了被配置成用于保持、运输和存储样品(例如临床和/或环境样品)的制备和加工中所使用的多个试剂和材料的试剂架。本文所提供的试剂架提供了在例如临床和/或环境样品的样品制备和处理中的若干优点，并且适于用于自动化样品处理装置。通过举例的方式，本文所公开的试剂架所提供的一些优点包括，但不限制于这样的设计：即(1)将试剂和样品的交叉污染减至最小；(2)促进试剂条/一次性用品的质量控制；(3)简化制作；以及(4)提供可用于不同的分子平台和自动化装置的灵活性。
本文中的保持器还被配置成由例如在多个样品上同时实施自动化样品制备的设备所用。例如，此种装置的示例性形式描述在国际专利申请公开号WO09/054870中，该申请通过引用以其整体并入本文。
例如通过PCR等方式，在诸如核酸检测(“NAT”)的测定中所使用的样品的制备可以包括以下步骤中的一个或多个：例如，在PCR或其他扩增的情况中，使多核苷酸样品与核酸检测NAT试剂混合物接触，该NAT试剂混合物包括聚合酶和多个核苷酸。在一些实施例中，该试剂混合物可以还包括带有可检测部分的杂交探针，其中所述探针具体地杂交至靶核酸(和/或阳性对照靶核酸序列)。
在一些实施例中，该试剂混合物当被存储在保持器上的试剂管内时可以是一个或多个冻干颗粒的形式，且该方法可以还包括通过液体重构试剂颗粒，以形成PCR试剂混合物溶液。本文中的保持器以自备的方式提供了用于制备准备核酸检测的样品所需的所有试剂，或者，当以套盒的形式递送至用户时，结合其它包装，包含了所有所需的试剂。合适的试剂和在DNA和RNA提取中使用该试剂的协议可以分别在美国专利申请公开号US2010-0009351以及US2009-0131650中找到，这些申请的每个均通过引用并入本文。
参考本文所提供的附图描述了本文描述的试剂保持器的若干特点。在图1A-图1H、图2A-图2C和图3中示出的示例性保持器的每个均可以被称为“组合一次性条状物”或“组合条状物”，因为它们旨在用作被配置成容纳所有试剂和需要执行样品制备的接收器的单一单元，并且因为其被布置成条状物形式。但是与本文说明书一致的是可预期到各种接收器的其他几何布置，所以该描述并不局限于直线、或条状布置，而是可以包括圆形或格子布置。
现在转向图1-图3，示出的是示例性试剂条100。试剂条100包括条状物110，该条状物110具有顶侧310和底侧320，并且该条状物容纳样品制备和/或处理中使用的各种组件，包括一个或多个移液管护套120、一个或多个处理管130，并且该条状物还容纳具有试剂管孔330的一个或多个一体化试剂管140。在一些实施例中，试剂管140与条状物110一体化形成/组合。在一些实施例中，处理管130与条状物110一体化形成。在一些实施例中，处理管130与组合条状物是分开的。在一些实施例中，试剂条包括一个或多个管接收器150。管接收器150可与条状物110一体化形成/组合，并且被配置成接收不与条状物110一体化形成/组合的一个或多个试剂管160。在一些实施例中，试剂管160可以与条状物一体化形成，如图2A所示。
通过举例的方式，本文所述的组合的试剂条可以包括在条状物上按任何配置组织的，例如，1、2、3、4、5、6、7、8、9、10或更多移液管护套，1、2、3、4、5、6、7、8、9、10或更多处理管，1、2、3、4、5、6、7、8、9、10或更多接收器，1、2、3、4、5、6、7、8、9、10或更多一体化试剂管，1、2、3、4、5或更多废物容器等。
在优选实施例中，试剂条包括与邻近的移液管护套和/或邻近的试剂管140大体分开的一个或更多个移液管护套120、处理管130、或管接收器150。优选地，移液管护套120与条状物110一体化形成，因此无需手动组装至条状物110上。借助于条状物110内所存在的各移液管端头孔口170，各移液管端头可以被插入至各移液管护套120中。移液管护套120大体上包围/围绕各移液管端头的侧面和底部。术语“大体上包围”，当用于指移液管护套时，意为护套至少包围移液管端头的主体。也就是，移液管端头的顶部可以包括在移液管端头的顶部部分(移液器由此插入)处的唇部等，该唇部延伸越过条状物110的顶部部分(可能停留在顶部部分上)。在一些实施例中，移液管护套包围移液管端头长度的例如70％、80％、85％、80％、90％、95％或更多。通过大体上包围各移液管端头，移液管护套防止每个移液管端头与条状物中存在的其他移液管端头、试剂管、处理管、废物容器等之间接触。具体地，每个移液管护套被配置成具有这样的材料，该材料围绕或形成将插入其中的移液管端头体与组合条状物内的其他试剂保持器或一次性用品(例如，其他移液管端头)隔开的隔板或壁290。因此，各移液管护套防止了在通过移液管制备和/或处理期间所操作的试剂和/或样品之间的任何交叉感染。例如，移液管护套120防止了相同条状物上的邻近移液管端头之间的污染，以及例如在自动化样品制备/处理装置内的保持在邻近位置的试剂端头中所容纳的移液管端头之间的污染。
在一些实施例中，移液管护套包含一个或多个护套孔口或芯孔180。在一些实施例中，芯孔180作为成对的护套孔口呈现，而在其他实施例中，芯孔不是孔口对的一部分。在一些实施例中，移液管护套包括一个、两个、三个、四个、五个、六个、七个、八个、九个、十个或更多的不成对的芯孔180。在一些实施例中，移液管护套包括多个孔口对，其中每个移液管护套孔口对包括两个芯孔180。例如，移液管护套可以包括，例如，一对、两对、三对、四对、五对、六对、七对、八对、九对、十对或更多的护套孔口对。移液管护套孔口对包括第一芯孔180a和第二芯孔180b，如图1D所示，这些芯孔存在于移液管护套120的相对侧上，并与移液管护套120的顶部等距。在一些实施例中，不成对的芯孔180可以存在于移液管护套120的相对侧上，并处于距移液管护套120的顶部的不同距离处。
芯孔180，无论是不成对存在还是作为孔口对而存在，可有利地用于手动(通过目视检查)或自动地(例如，通过光学传感器)确定在移液管护套120内存在或不存在移液管端头。因此，芯孔180在组合试剂条使用之前提供了额外的质量控制检查点。例如，在移液管端头的制动化检查的情况下，当芯孔180作为移液管护套孔口对而存在时，人们可将光通过孔口对的第一芯孔。当移液管护套120未容纳移液管端头时，光可通过在护套相对侧上对齐的孔口对的第一和第二芯孔。当移液管护套存在于护套内时，移液管端头阻挡或阻碍每个孔口对的第一和第二芯孔之间的可视通路。以这种方式，护套孔口对180可以易于用来确定移液管端头是否存在于每个护套120中。当存在芯孔180时，而不是移液管护套孔口对的部分，人们可以通过计算例如穿过不成对芯孔的光的反射或阻碍，来确定护套内存在或不存在移液管端头，因为反射或阻碍将根据移液管端头是存在还是不存在于移液管护套内而不同。例如，在一些实施例中，可以使用诸如回归反射型检测器的本领域已知的方法和装置来确定光反射的检查。在一些实施例中，例如通过使用诸如波束透射传感器的本领域已知方法和装置，来测量光的阻碍，从而测定护套内存在或不存在移液管端头。
如上所述，在一些实施例中，护套内存在不止一个移液管护套孔口对180，例如，如图3所示。当多个芯孔180存在于移液管护套内(例如，2、3、4、5、6、7、8、9、10或更多)时，每个芯孔可以存在于相对于限定移液管端头孔口的条状物110的顶侧沿移液管护套长度的不同位置或距离处。同理，沿单一移液管护套的长度可以存在多个护套孔口对180，其中相对于限定移液管端头孔口的条状物110的顶侧，每个护套孔口对180可以位于沿移液管护套120长度的不同位置或距离处。多个芯孔180沿移液管护套长度的布置(无论是不成对的或作为移液管护套孔口对一部分)提供了这样的能力，即不仅确定移液管端头是否存在于护套内，还提供确定插入至护套内的移液管端头的长度(尺寸)的能力。例如，当在护套120内存在较短的移液管端头时，端头可以更改通过芯孔180a导向的光的反射或阻碍，但端头可能过短而不能更改通过芯孔180d导向的光的反射或阻碍。同理，当存在多个护套孔口对时，移液管护套内存在的端头在光从芯孔180b离开时，可以阻碍通过芯孔180a导向的光的通路，但端头可能过短而不能阻碍通过护套孔口对180c、180d或180e、180f的光。因此，在试剂条的制造过程或组装过程中，移液管护套孔口对180能够通过允许快速确定端头的存在或不存在，而提供试剂条的质量控制的优势，其中端头的存在或不存在的快速确定可以手动执行(例如，通过个人的视觉检查)，或可易于自动化执行。例如，光学传感器可以用于传输和检查进入或离开孔口对180的第一或第二芯孔的光，以便检查每个单个护套120内移液管端头的存在或不存在(以及，例如长度)。
除了提供质量控制的优势外，芯孔180还可以促进试剂条100的制作。具体地，诸如通过注塑成型的移液管护套120的长且相对窄的护套的制作提出了极大的挑战。移液管护套通常是具有低拔模角/拔模斜度(draft angle)的长而窄形状的导管。长的中心销在例如制成试剂条的热塑性材料或热固性材料的高压注入下，将趋于移位，其中长的中心销通常用于例如本文所述的移液管端头护套的结构的注塑成型。不管芯孔180是成对存在还是作为护套孔口对的一部分，芯孔180的存在能够使通过模塑行为(mold action)产生的稳定销的使用用于稳定移液管护套120模塑所用的长的中心销。因此，芯孔180使得通过注塑成型来制作邻接的移液管护套可行，从而简化并降低制作成本。
在一些实施例中，试剂条包括具有相同长度的移液管护套。在一些实施例中，试剂条可以包括具有不同长度的移液管护套。例如，如图2所示，试剂条100可以包括具有第一长度230的一个或多个移液管护套140，以及具有第二长度240的一个或多个移液管护套240，如图所示，如2A中所示。因此，具有第一较长长度230的移液管护套能够容纳比具有第二较短长度240的移液管护套更长的移液管端头。如上面讨论的，在一些实施例中，移液管护套能够包括一个或多个不成对的芯孔180，或作为移液管护套孔口对呈现的芯孔。然而，在一些实施例中，移液管护套不包括任何芯孔180。在一些实施例中，例如，提供了试剂条，其中试剂条包括具有第一较长长度且沿护套的较长长度具有移液管护套孔口对的一个或多个移液管护套；以及具有第二较短长度且无芯孔或移液管护套孔口对的一个或多个移液管护套。然而，在一些实施例中，较长和较短移液管护套均可以包括至少一个不成对芯孔180，或至少一个移液管护套孔口对。在一些实施例中，较长移液管护套相比于较短移液管护套能够包括更多的不成对芯孔180或移液管护套孔口对。举例来说，较短移液管护套可以包含一个或更多芯孔180，或者一个或两个移液管护套孔口对，而较长移液管护套可以包含三个或四个不成对芯孔180，或三个或四个移液管护套孔口对。
如图3所示，移液管护套120在其基底处闭合，这样为收集来自使用后的移液管端头的任何液体或液滴提供空间。因为个体移液管护套大体上例如通过壁体分开。
如上所述，本文所公开的试剂条优选包括一个或多个接收器150。试剂条的接收器150可以被配置成用于接收分别包含足量的一种或多种试剂的试剂管，该试剂用于制备和/或处理生物和/或环境样品。在一些实施例中，试剂可以是固体形式，例如冻干的形式，用于实施样品制备和/或处理，例如，将核酸与样品分离以形成与保持器有关联的适于核酸检测(“NAT”)的样品。在一些实施例中，试剂可以是液体形式。
一个或多个接收器150可以是相同尺寸和形状，或可以是彼此不同的尺寸和形状。示出的接收器150具有开放的底部，但不局限于该拓扑结构，并且与条状物110的上侧内的入口220不同的是，接收器150可以是闭合的。优选地，接收器150被配置成接收实验室分析领域常用的容器、导管或管，或被适当配置成与本文的保持器一起使用的容器。因此，与条状物110并非一体化形成的试剂管160可以与试剂条分开存储，并且只是在使用前被卡入。这是有利的，因为不同的试剂(例如，核酸提取与PCR试剂)可能需要不同的存储条件。例如，冻干试剂可以是对湿气敏感的，并且需要不同的存储条件，即，例如裂解缓冲液。根据使用者想要对样品所执行的不同类型的制备/处理，因为包含了不同试剂的管可被装载至试剂条100中，所以试剂管的卡入式设计提供了多功能性。
本文所公开的条状物可以包括前缘190。前缘190可以被配置成有利于用户的处理。前缘190还可以被配置成促进试剂条100适当地插入和/或定位在例如自动化制备和处理装置内。前缘190可以包括某些识别特征，如颜色、条码、RFID等，以有利于识别和/或跟踪各个试剂条100。
在一些实施例中，试剂条100包括配准构件，诸如机械键250。通常，此种键是条状物110的一部分，例如，前缘190的一部分等。机械键确保了保持器被例如设备的支撑架或接收台内的互补构件接收，所述设备控制保持器内试剂的移液操作。机械键250一般是与接收设备中的对应切口或凸起匹配的特定形状的切口。因此，试剂条100可以包括机械键250，所述机械键包括条状物110的一端上的一对长方形切口。如图所示的该结构额外地提供了突出部，通过该突出部，使用者可以在将保持器插入支架或另一个设备以及从中移出时获得适当的抓握。本领域技术人员将明白机械键250结构的位置可以与本文所提供的附图所示的不同。例如，机械键250可以位于条状物110的另一端而不是前缘190。在一些实施例中，键250是便于保持器插入支架的成角度的切口，并且在靠近被配置成接收保持器的凹入区域中的互补的成角度切口时，确保了其中的良好配准。当然，机械键的其它变型与本文的描述一致：例如，弯曲切口、或槽口或凸起的各种组合都将有利于保持器的紧固配准。
在一些实施例中，该试剂条可以包括贴至条状物100的标识。标识可以是标签，例如可写标签、条形码、二维条形码或RFID标签。该标识符的目的可以是例如用于快速地展示保持器内所存在的是何种试剂组合，因此，想要何种类型的样品制备协议。标识还可以指示保持器所作出的批次，为了质量控制和保持记录的目的。标识还可以允许使用者将特定的保持器与特定样品匹配。
如上所述，诸如含有冻干试剂的试剂管140、160在无需塑料衬里层的情况下，可以通过诸如铝箔的金属箔密封其顶部，如本文进一步描述的。包含试剂的试剂管160可以被设置为单独的管，或包括完全分开的导管的多个管，其中例如导管经由连接器邻接在一起。例如，在一些实施例中，可共同提供不止一个试剂管160(例如，两个、三个、四个、五个、六个、七个、八个、九个、十个或更多)，其中试剂管共同卡入邻近接收器150的适当位置。举例来说，含有专门用于特定的NAT检测(例如，包含特定的、冻干扩增引物和/或探针和/或控制核酸)的试剂的多个试剂管160可以邻接在一起，并且易于卡入被配置成接收邻接在一起的多个分开的试剂管的条状物110中。在其它实施例中，接收器被配置为使得试剂管160可以被独立插入每个接收器150内。
含有不同试剂的一体化试剂管140和/或卡入式试剂管160可以具有不同的颜色，或用不同颜色编码以易于被使用者识别。例如，颜色编码的一体化试剂管140可以用于区分不同类型的组合试剂条，例如，该组合试剂条可以在不同的样品制备中使用。在卡入式试剂管160的情况下，颜色编码的管可以用于区分不同于彼此的试剂。举例来说，在用于DNA分离和生成PCR准备样本的组合试剂条的情况下，不同的颜色编码的试剂管160可以用来区分与不同NAT一起使用的管，例如不同NAT包含不同的引物对、探针等。例如，试剂管160可以由诸如有色塑料的不同颜色的材料制成，或在其上可以具有某种识别标签，诸如颜色条或点。试剂管160还可以具有印制在侧面上的标签，和/或可以具有标识符，诸如顶部上的密封层上的条形码。在一些实施例中，处理130和/或试剂管140、160可以是半透明的。
示出的试剂条100配有废物室200，其具有在条状物110上侧中的废物入口孔口210。废物室200是可选的，在存在废物室的实施例中，废物室200被配置成接收废弃的液体试剂。在不存在废物室的其它实施例中，废弃的液体试剂可以被转移到保持器外部的位置和在保持器外部的位置处被处理掉，保持器外部的位置诸如，例如包含正被分析含量的原始样品的试样管。所示的废物室200为包括另外两个或更多试剂管140的组件的一部分。将理解的是，做出此种布置是为了例如便于制造；废物室200的其它位置是可能的，如实施例中废物室200与试剂管140邻近，但除了经由条状物110并不连接到试剂管。
保持器通常使得条状物110、移液管护套120、处理管130、两个或多个试剂管140和废液室(如果存在)由单件制成，由诸如聚丙烯的材料制成。如以上其他地方所述，本文所公开的实施例的设计有利地促进组合试剂条由例如注塑成型制造。
图1G和图2C示出试剂条100的下侧320。如图2C所示，下侧320可以包括提供稳定性和灵活性的支柱300。
图1H示出了包含在一个移液管护套120中的移液管端头360的剖视图。
虽然本文所提供的附图示出的条状物被配置使得一个或多个移液管护套、一个或更多个接收器以及处理管和试剂管的各个孔口都相对于彼此直线布置(即，它们的中点位于相同轴线上)，但是本领域技术人员将明白，本文保持器不局限于接收器、废物室、处理管、移液管护套以及试剂管的特定配置。例如，一些实施例提供例如，具有交错孔口的较短试剂条，其中一些试剂管、处理管或移液管端头孔口占据“离轴”位置。如图1至图3所示，各种接收器等也并不需要占据相对于彼此的相同位置，其中处理管被设置为大致靠近保持器的中间，液体试剂被存储在安装在处理管一侧上的接收器内，以及保持固体试剂的接收器被安装在处理管另一侧上。因此，在图1-3中，处理管在条状物的一端上，而(多个)移液管护套在其另一端上，在内部位置中邻近废物室和两个或多个试剂管。其他的设置也是可能的，诸如将处理管安装在保持器的一端上，将处理管安装在邻近移液器端头和移液管端头护套处(如本文进一步所述)，以及将废物管安装在邻近处理管处。将理解的是，试剂条的不同部分的可替代配置仅产生形式的变化，并且可以被纳入所述设备的其它变型中，包括但不局限于样品的自动制备和处理的可替代指令集。
处理管130也可以是卡入式管，而不是一体化单件的一部分。处理管130可以用于样品制备期间发生的各种混合和反应过程。例如，当可提取核酸时，能够在处理管130中发生细胞裂解。然后，处理管130有利地定位在这样的位置，即整体上使得涉及将液体转移至处理管130的移液管头部移动操作最小的位置。
试剂管140通常被配置成容纳各种液体试剂。例如，在一些实施例中，试剂条可以包括三个试剂管，其中各试剂管均被提供有样品洗涤缓冲液、核酸释放缓冲液、核酸中和缓冲液，例如，以便为NAT检测纯化核酸。
可以用薄片结构400密封保持液体或液体试剂的试剂管140。薄片结构可以包括热密封层、诸如聚丙烯层的塑料层以及诸如铝箔的金属层，其中热密封层邻近一个或多个试剂管140。包含液体试剂的接收器的薄片中所使用的额外塑料薄膜通常是为了防止液体接触铝。
层结构不同的薄片结构400的示例性实施例描述在例如美国专利申请序列号2009/0129978中，该申请通过引用并入本文。在一些实施例中，薄片结构400的热密封层可以由例如漆或具有低熔点的其它聚合物制成，并在被如此施加时位于试剂条100的顶部，如图5A所示。薄片结构400可以包括由聚丙烯制成的热密封层410顶部上的塑料层420，其厚度范围为10-50微米。薄片结构400还可以包括塑料层顶部上的金属层，金属层包括通过粘着剂层430结合到塑料层420的一层铝箔440。可替换地，金属层可以是蒸发或溅射到恰好在塑料层上位置的一层金属，如图5B所示。
本文所部署的薄片更易于长期储存，因为保持器包括存在密封的冻干试剂以及接近密封的液体，这通常难以实现。
在一个实施例中，试剂管顶部具有倾斜边缘，使得在铝箔被热结合到顶部时，塑料熔化物不会延伸超出管的边沿。这是有利的，因为，如果塑料熔化物减少了管的内径，则在操作期间会对移液管端头造成干扰。在其它实施例中，凸起的扁平部260有利于薄片400的施加和移除。凸起的表面260是保持器的可选结构，其中凸起的表面位于连接构件的上侧上并围绕入口孔口至试剂管，并且可选地至废物室。
液体用移液管吸出的方式使得穿刺箔片的移液管端头裂开而不在移液管端头周围形成密封。在移液期间围绕端头的这种密封将是不利的，因为一定量的空气流对于移液操作是期望的。在该实例中，不形成密封，因为薄片结构400使被穿刺的箔片留在被穿刺时最初采用的位置。图4中的上部五个图解示出从用本文进一步所述的薄片密封的试剂管中移出试剂。在A处，移液管端头大约放置在包含试剂270的试剂管140上方中心处。在B处，移液管端头降低，通常可控制地降低到试剂管中，并且这样做时穿刺箔片280。该区域的分解图示出被穿刺的薄片的边缘，该边缘在穿过试剂管的移液管端头的最宽部分处与移液管端头接触。在C处，移液管端头稍微撤回，保持端头处于大量试剂270内。分解图示出被穿刺的箔片保持其被穿刺且移液管端头在试剂管内下降到其最深位置时所采用的配置。在D处，移液管端头吸取试剂270，可能改变其高度。在E处，移液管端头从试剂管中被完全取出。
各种管和室的材料可以被配置为具有至少内表面平滑性和表面涂层，从而减少核酸以及其他大分子粘着其上。核酸的粘着由于降低的敏感性是不希望的，而降低的敏感性很可能导致保持器表面上未被捕获的核酸的后续检测和分析。处理管也可以具有较低的粘着表面，并且允许磁珠在内壁轻易地上下滑动而不将其粘着。此外，处理管具有能够降低流体粘滞并因此降低核酸和其他分子粘着的疏水性表面涂层。本文所公开的试剂条能够由许多不同的聚合物制造，不同聚合物包括所有热塑性塑料、一些热固性塑料以及弹性体。优选地，材料适于注塑成型。本文所公开的条状物制造中有用的聚合物的非限制性示例包括例如环氧树脂和酚醛聚合物、尼龙、聚苯乙烯、聚苯乙烯聚合物等。优选地，试剂条由诸如聚丙烯的塑料制成，并且具有刚性尺寸，使得试剂条在其自身重量下不会明显下垂或弯曲，并在常规处理和运输期间也不会轻易变形，因此将不允许试剂从中漏出。
还应与本文说明书一致考虑的是保持器可以额外被配置为接收诸如试样管中的样品。因此，在本文其他地方所描述的实施例中，支架以这样的方式接收若干试样管和若干相应的保持器，即样品管和保持器可以彼此单独地和独立地被装载。然而，在其它实施例中，保持器可以被配置为也接收例如试样管内的样品。因此，互补支架被配置为接收若干保持器，其中每个保持器具有样品以及试剂和其他物品。在此种实施例中，保持器被配置为使得样品可进入样品鉴定检验器。
套盒
本文所述的试剂条可以作为套盒提供。例如，单个试剂条可以被包装在一起或单独地包装在密封袋内，以减少空气和湿气进入保持器内与试剂接触的机会。此种密封袋可以含有本文所述的一个或多个保持器，例如2、4、6、8、10、12、16、20或24个保持器。
保持器还可以作为套盒的一部分被提供，用于进行样品制备，其中套盒包括第一袋状物和第二袋状物，第一袋状物含有本文所述的一个或多个保持器，每个保持器配有用于例如溶解、洗涤以及释放的液体试剂，第二袋状物内部具有惰性气氛和含有冻干的PCR试剂的一个或多个试剂管。此种套盒还可以被配置成提供多个样品的分析，并含有足够的PCR试剂(或诸如用于RT-PCR、转录介导的扩增、链置换扩增、NASBA、解旋酶依赖扩增的其它扩增试剂，以及本领域普通技术人员熟悉的其他扩增试剂以及本文描述的其他扩增试剂)来处理此类样品，以及含有若干单个保持器，诸如2、4、6、8、10、12、16、20或24个保持器。

Claims (34)

1.一种组合试剂条，其包括：
具有顶侧和底侧的条状物，其包括：
包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述第一和第二移液管端头孔口每个包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，其中借助于所述条状物内所存在的各移液管端头孔口，各移液管端头可以被插入至各移液管护套中，并且其中每个所述第一和第二移液管护套被配置成通过大体上包围各移液管端头分别大体上包围第一和第二移液管端头的长度，其中所述第一和第二移液管护套防止每个移液管端头与其他移液管端头之间接触，
其中所述第一移液管护套和所述第二移液管护套各自包括孔口对，所述孔口对包括延伸穿过所述移液管护套的所述侧壁的第一芯孔和第二芯孔，其中所述第一和第二芯孔位于所述侧壁的相对侧上，并被设置在距所述移液管端头孔口沿所述移液管护套的长度的相同距离处，其中光学传感器可以用于传输和检查进入或离开孔口对的第一或第二芯孔的光，以便检查每个单个移液管护套内移液管端头的存在或不存在以及长度，
处理管；以及
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管。
2.根据权利要求1所述的组合试剂条，其中所述第一和第二移液管护套与相邻移液管护套大体分开。
3.根据权利要求1所述的组合试剂条，其中所述各移液管护套防止在通过移液管制备和/或处理期间所操作的试剂和/或样品之间的任何交叉污染。
4.根据权利要求1所述的组合试剂条，其中所述第一移液管护套包括多个孔口对。
5.根据权利要求1所述的组合试剂条，其中所述第一芯孔的位置在沿所述第一移液管护套的长度的一个距离处，使得当移液管端头插入所述第一移液管护套内时，所述移液管端头延伸越过所述第一移液管护套内的所述第一芯孔。
6.根据权利要求1所述的组合试剂条，其中所述第一和第二移液管端头孔口位于沿所述条状物的顶侧的邻近位置。
7.根据权利要求1所述的组合试剂条，其中所述第一和第二移液管护套具有从所述第一和第二移液管端头孔口延伸的不同的长度。
8.根据权利要求1所述的组合试剂条，其中所述第一移液管护套和所述第二移液管护套具有相同长度。
9.根据权利要求1所述的组合试剂条，其中所述处理管与所述条状物是一体化的，其中所述条状物包括处理管孔口，所述处理管孔口形成进入所述一体化处理管的开口。
10.根据权利要求9所述的组合试剂条，其包括多个一体化处理管。
11.根据权利要求1所述的组合试剂条，还包括一体化试剂管，其中所述条状物包括试剂管孔口，所述试剂管孔口形成进入所述一体化试剂管的开口。
12.根据权利要求11所述的组合试剂条，其包括多个一体化试剂管。
13.根据权利要求11所述的组合试剂条，其中所述一体化试剂管包括液体试剂。
14.根据权利要求11所述的组合试剂条，其还包括紧紧密封所述一体化试剂管孔口的薄片。
15.根据权利要求1所述的组合试剂条，其包括多个试剂接收器，其中所述多个接收器被配置成接收多个试剂管。
16.根据权利要求1所述的组合试剂条，其包括废物室，其中所述废物室与条状物是一体化的，并且其中所述废物室包括废物孔口，所述废物孔口形成进入所述一体化废物室的开口。
17.一种检测组合试剂条的移液管护套内的移液管端头的存在或不存在的方法，其包括：
提供所述组合试剂条，所述组合试剂条包括：
具有顶侧和底侧的条状物，其包括：
包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述第一和第二移液管端头孔口每个包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，其中借助于所述条状物内所存在的各移液管端头孔口，各移液管端头可以被插入至各移液管护套中，并且其中每个所述第一和第二移液管护套被配置成通过大体上包围各移液管端头分别大体上包围第一和第二移液管端头的长度，其中所述第一和第二移液管护套防止每个移液管端头与其他移液管端头之间接触，
其中所述第一移液管护套包括孔口对，所述孔口对包括延伸穿过所述第一移液管护套的所述侧壁的第一芯孔和第二芯孔，其中所述第一和第二芯孔位于所述侧壁的相对侧上，并被设置在距所述第一移液管端头孔口沿所述第一移液管护套的长度的相同距离处，
处理管；以及
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管；
提供穿过所述孔口对的所述第一芯孔的光束；以及
检测所述光束是否穿过所述孔口对的所述第二芯孔无阻退出，
确定移液管端头是否存在于所述第一移液管护套内，其中所述光束穿过所述第一移液管护套的所述第二芯孔的无阻退出指示了所述第一移液管护套内不存在所述移液管端头，其中所述光束穿过所述第二芯孔受阻退出指示了所述第一移液管护套内存在所述移液管端头。
18.一种确定组合试剂条的移液管护套内的移液管端头的长度的方法，其包括：
提供组合试剂条，其包括：
具有顶侧和底侧的条状物，其包括：
处理管；
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管；
第一和第二移液管护套，其包括：
第一和第二移液管端头孔口，其每个分别包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套内，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围所述第一和第二移液管端头的长度；
所述第一移液管护套内的顶部移液管护套孔口对和底部移液管护套孔口对，所述顶部和底部移液管护套孔口对每个均包括延伸穿过所述第一移液管护套的侧壁的第一芯孔和第二芯孔，其中所述顶部和底部移液管护套孔口对的所述第一和第二芯孔位于所述第一移液管护套的相对侧上并且被设置在距所述第一移液管端头孔口沿所述第一移液管护套的长度的相同距离处，并且其中所述顶部移液管护套孔口对比所述底部移液管护套孔口对位于更接近所述第一移液管端头孔口处；
提供穿过所述顶部移液管护套孔口对的所述第一芯孔的光；
提供穿过所述底部移液管护套孔口对的所述第一芯孔的光；
检测所述光是否在穿过所述顶部移液管护套孔口对的所述第二芯孔时受阻；以及
检测所述光是否在穿过所述底部移液管护套孔口对的所述第二芯孔时受阻，
其中所述光穿过所述顶部移液管护套孔口对的所述第二芯孔受阻以及所述光穿过所述底部移液管护套孔口对的第二芯孔指示了所述第一移液管护套内的所述移液管端头在被插入至所述第一移液管护套时具有没有向下延伸至所述底部移液管护套孔口对的长度。
19.一种检测组合试剂条的移液管护套内的移液管端头的存在或不存在的方法，其包括：
提供所述组合试剂条，所述组合试剂条包括：
具有顶侧和底侧的条状物，其包括：
包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述第一和第二移液管端头孔口每个包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，其中借助于所述条状物内所存在的各移液管端头孔口，各移液管端头可以被插入至各移液管护套中，并且其中每个所述第一和第二移液管护套被配置成通过大体上包围各移液管端头分别大体上包围第一和第二移液管端头的长度，其中所述第一和第二移液管护套防止每个移液管端头与其他移液管端头之间接触，
其中所述第一移液管护套包括第一芯孔，所述第一芯孔延伸穿过所述第一移液管护套的侧壁，
处理管；以及
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管；
提供穿过所述第一芯孔进入所述第一移液管护套的光束，以及
将所述光束的反射或阻碍确定为指示存在或不存在移液管端头，其中所述移液管端头在所述第一移液管护套内延伸至从所述第一移液管端头孔口到所述第一芯孔的距离。
20.根据权利要求19所述的方法，其中多个芯孔沿所述移液管护套的长度的布置不仅提供确定护套内是否存在移液管端头的能力，还进一步提供确定插入在所述护套内的所述移液管尖端的长度的能力。
21.一种确定组合试剂条的移液管护套内的移液管端头的长度的方法，包括：
提供组合试剂条，其包括：
具有顶侧和底侧的条状物，其包括：
处理管；以及
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管；
第一和第二移液管护套，其包括：
第一和第二移液管端头孔口，其每个分别包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套内，并且其中所述第一和第二移液管护套的每个被配置成分别大体上包围所述第一和第二移液管端头的长度；
所述第一移液管护套内的顶部芯孔和底部芯孔，所述顶部和底部芯孔中的每个延伸穿过所述第一移液管护套的侧壁，其中所述顶部芯孔比所述底部芯孔位于更接近所述第一移液管端头孔口处，其中所述顶部芯孔和所述底部芯孔可以用于或者通过目视检查手动地或者通过光学传感器自动地确定在所述第一移液管护套内存在或不存在移液管端头；
确定移液管端头在所述第一移液管护套内是否从所述第一移液管端头孔口延伸至所述顶部芯孔的距离；以及
确定所述移液管端头在所述第一移液管护套内是否从所述第一移液管端头孔口延伸至所述底部芯孔的距离。
22.根据权利要求21的所述方法，其中所述确定包括通过所述顶部芯孔和所述底部芯孔目视检查所述第一移液管护套的内部。
23.根据权利要求21的所述方法，其中所述确定包括：
提供通过所述顶部芯孔的光束；
提供通过所述底部芯孔的光束；
将所述第一和第二光束的反射或阻碍确定为指示存在或不存在移液管端头，其中所述移液管端头在所述第一移液管护套内分别从所述第一移液管端头孔口延伸至所述顶部芯孔和所述底部芯孔的距离。
24.根据权利要求21的所述方法，其中确定移液管端头是否在所述第一移液管护套内从所述第一移液管端头孔口延伸至所述顶部芯孔包括：
提供通过所述顶部芯孔的光束；和
将所述光束的反射或阻碍确定为指示存在或不存在移液管端头，其中所述移液管端头在所述第一移液管护套内从所述第一移液管端头孔口延伸至所述顶部芯孔。
25.根据权利要求21的所述方法，其中确定移液管端头是否在所述第一移液管护套内从所述第一移液管端头孔口延伸至所述底部芯孔包括：
提供通过所述底部芯孔的光束；和
将所述光束的反射或阻碍确定为指示存在或不存在移液管端头，其中所述移液管端头在所述第一移液管护套内从所述第一移液管端头孔口延伸至所述底部芯孔。
26.一种组合试剂条，其包括：
具有顶侧和底侧的条状物，其包括：
包括相对侧的第一和第二移液管护套，所述第一和第二移液管护套分别包括第一和第二移液管端头孔口，所述第一和第二移液管端头孔口每个包括所述条状物的顶侧上的独立开口，并且其中所述第一和第二移液管端头孔口被配置成将第一和第二移液管端头分别插入所述第一和第二移液管护套，其中借助于所述条状物内所存在的各移液管端头孔口，各移液管端头可以被插入至各移液管护套中，并且其中每个所述第一和第二移液管护套被配置成通过大体上包围各移液管端头分别大体上包围第一和第二移液管端头的长度，其中所述第一和第二移液管护套防止每个移液管端头与其他移液管端头之间接触，
所述第一移液管护套内的顶部芯孔和底部芯孔，所述顶部和底部芯孔中的每个延伸穿过所述第一移液管护套的侧壁，其中所述顶部芯孔比所述底部芯孔位于更接近所述第一移液管端头孔口处，其中所述顶部芯孔和所述底部芯孔可以用于或者通过目视检查手动地或者通过光学传感器自动地确定在所述第一移液管护套内存在或不存在移液管端头，
处理管；以及
接收器，其包括穿过所述试剂条的开口，其中所述接收器被配置成接收试剂管。
27.根据权利要求26所述的组合试剂条，其中所述第一移液管护套包括多个孔口对。
28.根据权利要求26所述的组合试剂条，其中所述第二移液管护套包括延伸通过所述第二移液管护套的侧壁的第一芯孔。
29.根据权利要求26所述的组合试剂条，其中所述第二移液管护套不包括芯孔。
30.根据权利要求26所述的组合试剂条，其中所述第一芯孔的位置在沿所述第一移液管护套的长度的一个距离处，使得当移液管端头插入所述第一移液管护套内时，所述移液管端头延伸越过所述第一移液管护套内的所述第一芯孔。
31.根据权利要求26所述的组合试剂条，其中所述第一移液管护套包括孔口对，所述孔口对包括延伸穿过所述第一移液管护套的所述侧壁的所述第一芯孔和第二芯孔，其中所述第一和第二芯孔位于所述侧壁的相对侧上，并被设置在距所述第一移液管端头孔口沿所述第一移液管护套的长度的相同距离处。
32.根据权利要求26所述的组合试剂条，其中所述第二移液管护套包括移液管护套孔口对，所述孔口对包括延伸穿过所述第二移液管护套的侧壁的第一和第二芯孔，其中所述第一和第二芯孔位于所述侧壁的相对侧上并且被设置在距所述第二移液管端头孔口沿所述第二移液管护套的长度的相同距离处。
33.根据权利要求26所述的组合试剂条，其中所述第一移液管护套和所述第二移液管护套各自包括孔口对，所述孔口对包括延伸穿过所述移液管护套的所述侧壁的第一芯孔和第二芯孔，其中所述第一和第二芯孔位于所述侧壁的相对侧上，并被设置在距所述移液管端头孔口沿所述移液管护套的长度的相同距离处。
34.根据权利要求26所述的组合试剂条，其中光学传感器可以用于传输和检查进入或离开孔口对的第一或第二芯孔的光，以便检查每个单个移液管护套内移液管端头的存在或不存在以及长度。
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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
JP5415253B2 (ja) 2006-03-24 2014-02-12 ハンディラブ・インコーポレーテッド 微小流体サンプルを処理するための一体化システム及びその使用方法
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9804179B2 (en) 2011-01-08 2017-10-31 Access Medical Systems, Ltd. Systems for immunoassay tests
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR102121853B1 (ko) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 일체화된 시약 스트립
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
RU2627383C2 (ru) 2012-04-13 2017-08-08 Бектон, Дикинсон Энд Компани Дополнительное исследование проб с применением остаточных материалов от предыдущего теста
EP3034169A1 (de) * 2014-12-15 2016-06-22 Euroimmun Medizinische Labordiagnostika AG Vorratsbehälter für Flüssigkeiten
WO2017093763A2 (en) * 2015-12-04 2017-06-08 The Technology Partnership Plc Sample preparation system and cartridge
USD789217S1 (en) * 2016-01-12 2017-06-13 Peter Antons Prescription container tray
JP1565699S (zh) * 2016-01-12 2016-12-19
USD814652S1 (en) * 2016-10-14 2018-04-03 Spartan Bioscience In. Cartridge
CN106367309B (zh) * 2016-11-22 2019-01-04 安图实验仪器(郑州)有限公司 适于核酸诊断系统的单排核酸提取盒
EP3636738A4 (en) * 2017-05-12 2021-01-13 Universal Bio Research Co., Ltd. CARTRIDGE FOR NUCLEIC ACID DETECTION
CN107557873A (zh) * 2017-09-05 2018-01-09 苏州普川生物科技有限公司 一种单人份文库构建试剂盒
WO2019087176A1 (en) * 2017-11-02 2019-05-09 Memed Diagnostics Ltd. Cartridge and system for analyzing body liquid
JP1606642S (zh) * 2017-12-14 2018-06-11
CH714486A1 (de) * 2017-12-21 2019-06-28 Integra Biosciences Ag Probenverteilsystem und Verfahren zum Verteilen von Proben.
CN107966580A (zh) * 2017-12-26 2018-04-27 江苏柯伦迪医疗技术有限公司 一种应用条式检测卡的快速自动生化检测系统及方法
CN108196081A (zh) * 2018-01-23 2018-06-22 深圳市国赛生物技术有限公司 一种poct特定蛋白分析系统
CN109212237A (zh) * 2018-08-31 2019-01-15 深圳市国赛生物技术有限公司 糖化血红蛋白检测用试剂盒组件
USD951482S1 (en) 2018-09-02 2022-05-10 Memed Diagnostics Ltd. Cartridge device
GB201905230D0 (en) * 2019-04-12 2019-05-29 Randox Laboratories Ltd Pipette tip carrier assembly
CN110132845A (zh) * 2019-05-15 2019-08-16 浙江拱东医疗器械股份有限公司 Cv值改善后的检测试剂条
US20210129154A1 (en) * 2019-11-06 2021-05-06 Life Technologies Corporation Pipette tip tray
CN111334417A (zh) * 2020-04-14 2020-06-26 无锡科智达科技有限公司 预分装磁珠法核酸提取装置
USD998172S1 (en) * 2021-03-12 2023-09-05 Ultima Genomics, Inc. Sample rack

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143250A (en) * 1995-07-31 2000-11-07 Precision System Science Co., Ltd. Multi-vessel container for testing fluids
US6238626B1 (en) * 1998-04-13 2001-05-29 Matsushita Electric Industrial Co., Ltd. Automatic distribution apparatus and method of distribution
WO2004055522A1 (en) * 2002-12-13 2004-07-01 Innotrac Diagnostics Oy Analyzer and analysing method and a fluid cartridge
CN101802164A (zh) * 2007-07-13 2010-08-11 汉迪实验室公司 用于在多个生物样品上进行核酸提取和诊断测试的集成装置
CN101918581A (zh) * 2007-10-10 2010-12-15 普凯尔德诊断技术有限公司 用于鉴定尿中细菌的系统

Family Cites Families (907)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1434314A (en) 1921-08-04 1922-10-31 Raich Anthony Lunch pail
US1616419A (en) 1925-04-03 1927-02-01 Everlasting Valve Co Automatic shut-off device for gas in case of fire
US1733401A (en) 1928-03-29 1929-10-29 Christman Matthias Journal box
NL109202C (zh) 1959-11-20
GB1095429A (zh) 1965-05-17
US3528449A (en) 1968-02-27 1970-09-15 Trw Inc Fluid flow control apparatus
US3813316A (en) 1972-06-07 1974-05-28 Gen Electric Microorganisms having multiple compatible degradative energy-generating plasmids and preparation thereof
US4038192A (en) 1973-12-03 1977-07-26 International Biomedical Laboratories, Inc. Device for exchange between fluids suitable for treatment of blood
JPS5348Y2 (zh) 1974-01-19 1978-01-05
US3985649A (en) 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
JPS5255578A (en) 1975-10-31 1977-05-07 Hitachi Ltd Analyzing apparatus
US4018652A (en) 1976-01-09 1977-04-19 Mcdonnell Douglas Corporation Process and apparatus for ascertaining the concentration of microorganism in a water specimen
US4018089A (en) 1976-05-05 1977-04-19 Beckman Instruments, Inc. Fluid sampling apparatus
USD249706S (en) 1976-12-17 1978-09-26 Eastman Kodak Company Sample cup tray for chemical analysis of biological fluids
USD252157S (en) 1977-04-14 1979-06-19 Warner-Lambert Company Diagnostic device for measuring biochemical characteristics of microorganisms and the like
USD252341S (en) 1977-05-12 1979-07-10 Ryder International Corporation Testing tray
JPS5416896A (en) 1977-06-21 1979-02-07 Asahi Medical Co Blood dialyser
US4139005A (en) 1977-09-01 1979-02-13 Dickey Gilbert C Safety release pipe cap
USD254687S (en) 1979-01-25 1980-04-08 Mcdonnell Douglas Corporation Biochemical card for use with an automated microbial identification machine
USD261033S (en) 1979-02-05 1981-09-29 American Optical Corporation Bilirubin concentration analyzer
USD261173S (en) 1979-02-05 1981-10-06 American Optical Corporation Bilirubinometer
US4301412A (en) 1979-10-29 1981-11-17 United States Surgical Corporation Liquid conductivity measuring system and sample cards therefor
JPS5766361A (en) 1980-10-09 1982-04-22 Olympus Optical Co Ltd Plate-shaped apparatus for judging cohesion of particle
US4472357A (en) 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4457329A (en) 1981-12-04 1984-07-03 Air Products And Chemicals, Inc. Safety pressure regulator
JPS58212921A (ja) 1982-06-04 1983-12-10 Aron Kasei Co Ltd プラスチツクス中空成形物の成形方法
USD279817S (en) 1982-07-19 1985-07-23 Daryl Laboratories, Inc. Immunoassay test slide
US4504582A (en) 1982-07-20 1985-03-12 Genex Corporation Vermiculite as a carrier support for immobilized biological materials
US4439526A (en) 1982-07-26 1984-03-27 Eastman Kodak Company Clustered ingress apertures for capillary transport devices and method of use
ATE34618T1 (de) 1982-09-02 1988-06-15 Hettich Andreas Fa Zentrifugationskammern zur zytodiagnostischen praeparation von epithelzellen und deren verwendung.
US4647432A (en) 1982-11-30 1987-03-03 Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha Automatic analysis apparatus
USD282208S (en) 1983-02-07 1986-01-14 Data Packaging Corporation Pipetter tip cartridge
US4522786A (en) 1983-08-10 1985-06-11 E. I. Du Pont De Nemours And Company Multilayered test device for detecting analytes in liquid test samples
US4673657A (en) 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
US4599315A (en) 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
USD292735S (en) 1983-11-02 1987-11-10 A/S Nunc Tube for the immunological adsorption analysis
US4724207A (en) 1984-02-02 1988-02-09 Cuno Incorporated Modified siliceous chromatographic supports
US4654127A (en) 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
JP2502961B2 (ja) 1984-04-26 1996-05-29 日本碍子株式会社 電気化学的装置の製造方法
USD288478S (en) 1984-06-21 1987-02-24 Sentech Medical Corporation Clinical chemistry analyzer
JPH06104118B2 (ja) 1985-03-13 1994-12-21 バクスタ−、インターナショナル、インコ−ポレイテッド 血小板採取システム
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4612959A (en) 1985-05-07 1986-09-23 Mobil Oil Corporation Valveless shut-off and transfer device
US4720374A (en) 1985-07-22 1988-01-19 E. I. Du Pont De Nemours And Company Container having a sonication compartment
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4678752A (en) 1985-11-18 1987-07-07 Becton, Dickinson And Company Automatic random access analyzer
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
JPS62119460U (zh) 1986-01-22 1987-07-29
DE3614955C1 (de) 1986-05-02 1987-08-06 Schulz Peter Proben-Verteiler-System
US4978622A (en) 1986-06-23 1990-12-18 Regents Of The University Of California Cytophaga-derived immunopotentiator
US5763262A (en) 1986-09-18 1998-06-09 Quidel Corporation Immunodiagnostic device
USD302294S (en) 1986-10-03 1989-07-18 Biotrack, Inc. Reagent cartridge for blood analysis
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
US4978502A (en) 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US5004583A (en) 1987-01-29 1991-04-02 Medtest Systems, Inc. Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid
US4946562A (en) 1987-01-29 1990-08-07 Medtest Systems, Inc. Apparatus and methods for sensing fluid components
DE3850273T2 (de) 1987-03-02 1994-09-29 Gen Probe Inc Polykationische Träger zur Reinigung, Trennung und Hybridisierung von Nukleinsäure.
US5599667A (en) 1987-03-02 1997-02-04 Gen-Probe Incorporated Polycationic supports and nucleic acid purification separation and hybridization
US4855110A (en) 1987-05-06 1989-08-08 Abbott Laboratories Sample ring for clinical analyzer network
US5001417A (en) 1987-06-01 1991-03-19 Abbott Laboratories Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes
US5192507A (en) 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
JPH0354470Y2 (zh) 1987-07-15 1991-12-02
WO1989000446A1 (en) 1987-07-16 1989-01-26 E.I. Du Pont De Nemours And Company Affinity separating using immobilized flocculating reagents
US4827944A (en) 1987-07-22 1989-05-09 Becton, Dickinson And Company Body fluid sample collection tube composite
GB8720470D0 (en) 1987-08-29 1987-10-07 Emi Plc Thorn Sensor arrangements
US4921809A (en) 1987-09-29 1990-05-01 Findley Adhesives, Inc. Polymer coated solid matrices and use in immunoassays
USD312692S (en) 1987-10-09 1990-12-04 Bradley Marshall C Pipette holder
USD310413S (en) 1987-12-17 1990-09-04 Miles Inc. Sample processor
US4895650A (en) 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
JPH0720010Y2 (ja) 1988-02-25 1995-05-10 株式会社吉野工業所 ブロー成型容器
JPH01219669A (ja) * 1988-02-29 1989-09-01 Shimadzu Corp 液体試料容器の類別検出方法
US5503803A (en) 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
DE3811713A1 (de) 1988-04-08 1989-10-19 Bosch Gmbh Robert Planare polarographische sonde zur bestimmung des (lambda)-wertes von gasgemischen
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5060823A (en) 1988-09-15 1991-10-29 Brandeis University Sterile transfer system
US5096669A (en) 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
DE8813340U1 (zh) 1988-10-24 1988-12-08 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad, De
JPH0814337B2 (ja) 1988-11-11 1996-02-14 株式会社日立製作所 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4919829A (en) 1988-12-30 1990-04-24 The United States Of America As Represented By The Secretary Of Commerce Aluminum hydroxides as solid lubricants
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5053199A (en) 1989-02-21 1991-10-01 Boehringer Mannheim Corporation Electronically readable information carrier
US5416000A (en) 1989-03-16 1995-05-16 Chemtrak, Inc. Analyte immunoassay in self-contained apparatus
FI86229C (fi) 1989-04-10 1992-07-27 Niilo Kaartinen Foerfarande foer formning av ett uppvaermbart och nedkylbart element vid ett system behandlande smao vaetskemaengder samt ett medelst foerfarandet framstaellt element.
US4949742A (en) 1989-04-26 1990-08-21 Spectra-Physics, Inc. Temperature operated gas valve
US5135872A (en) 1989-04-28 1992-08-04 Sangstat Medical Corporation Matrix controlled method of delayed fluid delivery for assays
US5071531A (en) 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5061336A (en) 1989-05-01 1991-10-29 Soane Technologies, Inc. Gel casting method and apparatus
AU109440S (en) 1989-05-03 1990-10-31 Bayer Diagnostic G M B H Diagnostic working station evaluation device
USD325638S (en) 1989-07-10 1992-04-21 Hach Company Microtester or the like
USD328794S (en) 1989-07-19 1992-08-18 Pb Diagnostic Systems, Inc. Diagnostic instrument or similar article
AU635314B2 (en) 1989-09-08 1993-03-18 Terumo Kabushiki Kaisha Measuring apparatus
EP0420560B1 (en) 1989-09-29 1993-11-18 Glory Kogyo Kabushiki Kaisha Leaf paper bundling apparatus
US5275787A (en) 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
LU87601A1 (fr) 1989-10-05 1990-02-07 Ceodeux Sa Robinet pour bouteille de gaz
USD324426S (en) 1989-10-20 1992-03-03 Pacific Biotech, Inc. Reaction unit for use in analyzing biological fluids
US4967950A (en) 1989-10-31 1990-11-06 International Business Machines Corporation Soldering method
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5091328A (en) 1989-11-21 1992-02-25 National Semiconductor Corporation Method of late programming MOS devices
JP2731613B2 (ja) 1989-12-12 1998-03-25 株式会社クラレ 酵素免疫測定用カートリツジ、それを用いた測定方法及び測定装置
US5279936A (en) 1989-12-22 1994-01-18 Syntex (U.S.A.) Inc. Method of separation employing magnetic particles and second medium
USD328135S (en) 1990-01-12 1992-07-21 Pacific Biotech, Inc. Reaction unit for use in analyzing biological fluids
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US6054034A (en) 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
GB9007791D0 (en) 1990-04-06 1990-06-06 Foss Richard C High voltage boosted wordline supply charge pump and regulator for dram
WO1991016675A1 (en) 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
AU639575B2 (en) 1990-05-01 1993-07-29 Enprotech Corporation Integral biomolecule preparation device
US5667976A (en) 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
DE4023194A1 (de) 1990-07-20 1992-01-23 Kodak Ag Vorrichtung mit mehreren einreihig angeordneten aufnahmen fuer mit fluessigkeit gefuellte behaelter
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5208163A (en) 1990-08-06 1993-05-04 Miles Inc. Self-metering fluid analysis device
JPH0734375Y2 (ja) 1990-09-11 1995-08-02 株式会社シノテスト 被検体物質の反応測定検出器具
WO1992005443A1 (en) 1990-09-15 1992-04-02 Medical Research Council Reagent separation
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
US5141718A (en) 1990-10-30 1992-08-25 Millipore Corporation Test plate apparatus
EP0484278B1 (de) 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
DE59104604D1 (de) 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
FR2672301A1 (fr) 1991-02-01 1992-08-07 Larzul Daniel Procede et dispositif pour amplifier le nombre d'une sequence definie d'acide nucleique dans un echantillon biologique.
US5327038A (en) 1991-05-09 1994-07-05 Rockwell International Corporation Walking expansion actuator
JPH05345900A (ja) 1991-07-08 1993-12-27 Fuji Oil Co Ltd 硬質油脂の製造法
DE4123348A1 (de) 1991-07-15 1993-01-21 Boehringer Mannheim Gmbh Elektrochemisches analysesystem
USD333522S (en) 1991-07-23 1993-02-23 P B Diagnostic Systems, Inc. Sample tube holder
IT1249433B (it) 1991-08-06 1995-02-23 Pompeo Moscetta Procedimento per il dosaggio di analiti in campioni liquidi e relativaapparecchiatura.
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5256376A (en) 1991-09-12 1993-10-26 Medical Laboratory Automation, Inc. Agglutination detection apparatus
WO1993006992A1 (en) 1991-10-04 1993-04-15 Alcan International Limited Peelable laminated structures and process for production thereof
CA2074671A1 (en) 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
USD347478S (en) 1991-11-05 1994-05-31 Hybaid Ltd. Laboratory instrument for handling bimolecular samples
JP3509859B2 (ja) 1991-11-07 2004-03-22 ナノトロニクス，インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
USD340289S (en) 1992-01-30 1993-10-12 Jan Gerber Diagnostic testing material
US5559432A (en) 1992-02-27 1996-09-24 Logue; Delmar L. Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core
US5217694A (en) 1992-03-25 1993-06-08 Gibler W Brian Holder for evacuated test tubes
US5646049A (en) 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
JPH07505297A (ja) 1992-04-06 1995-06-15 アボツト・ラボラトリーズ 内面全反射を使用して核酸または被分析物質を検出する方法及び装置
US5223226A (en) 1992-04-14 1993-06-29 Millipore Corporation Insulated needle for forming an electrospray
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US6953676B1 (en) 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5401465A (en) 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5364591A (en) 1992-06-01 1994-11-15 Eastman Kodak Company Device for moving a target-bearing solid through a liquid for detection while being contained
US5414245A (en) 1992-08-03 1995-05-09 Hewlett-Packard Corporation Thermal-ink heater array using rectifying material
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
DE4231966A1 (de) 1992-09-24 1994-03-31 Bosch Gmbh Robert Planare polarograhische Sonde zur Bestimmung des Lambda-Wertes von Gasgemischen
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5885432A (en) 1992-11-05 1999-03-23 Soane Biosciences Un-crosslinked polymeric media for electrophoresis
US5569364A (en) 1992-11-05 1996-10-29 Soane Biosciences, Inc. Separation media for electrophoresis
GB9223334D0 (en) 1992-11-06 1992-12-23 Hybaid Ltd Magnetic solid phase supports
US5500187A (en) 1992-12-08 1996-03-19 Westinghouse Electric Corporation Disposable optical agglutination assay device and method for use
US5302348A (en) 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5311996A (en) 1993-01-05 1994-05-17 Duffy Thomas J Edge protector
DE4334834A1 (de) 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen
FI932866A0 (fi) 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
JPH0664156U (ja) 1993-02-16 1994-09-09 株式会社ニッテク 血液容器の保持構造
USD351913S (en) 1993-02-25 1994-10-25 Diametrics Medical, Inc. Disposable electrochemical measurement cartridge for a portable medical analyzer
US5339486A (en) 1993-03-10 1994-08-23 Persic Jr William V Golf ball cleaner
US5565171A (en) 1993-05-28 1996-10-15 Governors Of The University Of Alberta Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
JP3339650B2 (ja) 1993-07-02 2002-10-28 和光純薬工業株式会社 液体分注装置
DE69429038T2 (de) 1993-07-28 2002-03-21 Pe Corp Ny Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
USD356232S (en) 1993-08-20 1995-03-14 Flair Communications Agency, Inc. Dual vesselled beverage container
US5397709A (en) 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
DE59410283D1 (de) 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
DE4343089A1 (de) 1993-12-17 1995-06-29 Bosch Gmbh Robert Planares Sensorelement auf Festelektrolytbasis
CA2143365A1 (en) 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
US5725831A (en) 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
DE4408361C2 (de) 1994-03-14 1996-02-01 Bosch Gmbh Robert Elektrochemischer Sensor zur Bestimmung der Sauerstoffkonzentration in Gasgemischen
JPH09510614A (ja) 1994-03-24 1997-10-28 ガメラ・バイオサイエンス・コーポレイション Ｄｎａメルトメーターおよびその使用方法
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
USD366116S (en) 1994-05-03 1996-01-09 Thomas Biskupski Electrical box for storing dental wax
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5514343A (en) 1994-06-22 1996-05-07 Nunc, As Microtitration system
FR2722294B1 (fr) 1994-07-07 1996-10-04 Lyon Ecole Centrale Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede
RU2153513C2 (ru) 1994-07-14 2000-07-27 Тоунджет Корпорейшн Пти. Лтд. Твердые чернила для струйного принтера
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
CA2156226C (en) 1994-08-25 1999-02-23 Takayuki Taguchi Biological fluid analyzing device and method
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
JP3652424B2 (ja) 1994-10-27 2005-05-25 日本政策投資銀行 自動分析装置及びその方法
JP3403839B2 (ja) 1994-10-27 2003-05-06 プレシジョン・システム・サイエンス株式会社 カートリッジ容器
US5721136A (en) 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5846396A (en) 1994-11-10 1998-12-08 Sarnoff Corporation Liquid distribution system
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US5731212A (en) 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US5846493A (en) 1995-02-14 1998-12-08 Promega Corporation System for analyzing a substance from a solution following filtering of the substance from the solution
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US5579928A (en) 1995-03-06 1996-12-03 Anukwuem; Chidi I. Test tube holder with lock down clamp
US6967088B1 (en) 1995-03-16 2005-11-22 Allergan, Inc. Soluble recombinant botulinum toxin proteins
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US5674394A (en) 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
DE19512368A1 (de) 1995-04-01 1996-10-02 Boehringer Mannheim Gmbh System zur Freisetzung und Isolierung von Nukleinsäuren
USD382346S (en) 1995-04-19 1997-08-12 Roche Diagnostic Systems, Inc. Vessel holder
US5700429A (en) 1995-04-19 1997-12-23 Roche Diagnostic Systems, Inc. Vessel holder for automated analyzer
US5578818A (en) 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
DE19519015C1 (de) 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
CA2222506C (en) 1995-06-06 2007-07-24 Quantic Biomedical Partners Device and method for concentrating plasma
EP0883442A4 (en) 1995-06-06 1999-10-27 Sarnoff Corp ELECTROKINETIC PUMPING
US6228635B1 (en) 1995-06-07 2001-05-08 Aastrom Bioscience, Inc. Portable cell growth cassette for use in maintaining and growing biological cells
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6158269A (en) 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
JP3923968B2 (ja) 1995-07-31 2007-06-06 プレシジョン・システム・サイエンス株式会社 容器使用方法
JP3927570B2 (ja) 1995-07-31 2007-06-13 プレシジョン・システム・サイエンス株式会社 容器
US5849208A (en) 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
AU7238396A (en) 1995-09-12 1997-04-01 Becton Dickinson & Company Device and method for dna amplification and assay
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6911183B1 (en) 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
GB9519346D0 (en) 1995-09-22 1995-11-22 English Glass Company The Limi Dispensing systems
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
US6132580A (en) 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US20020068357A1 (en) 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
DE69513658T2 (de) 1995-09-29 2000-05-31 St Microelectronics Srl Spannungsregler für nichtflüchtige, elektrisch programmierbare Halbleiterspeicheranordnungen
US5651839A (en) 1995-10-26 1997-07-29 Queen's University At Kingston Process for engineering coherent twin and coincident site lattice grain boundaries in polycrystalline materials
US5705813A (en) 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
DE19540877C2 (de) 1995-11-02 1998-02-26 Byk Sangtec Diagnostica Modulare Reagenzienkartusche
AU702403B2 (en) 1995-12-05 1999-02-18 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
USD382647S (en) 1996-01-17 1997-08-19 Biomerieux Vitek, Inc. Biochemical test card
US5631337A (en) 1996-01-19 1997-05-20 Soane Bioscience Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5883211A (en) 1996-01-19 1999-03-16 Aclara Biosciences, Inc. Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5726944A (en) 1996-02-05 1998-03-10 Motorola, Inc. Voltage regulator for regulating an output voltage from a charge pump and method therefor
US5981735A (en) 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
US5736102A (en) 1996-02-21 1998-04-07 Biomerieux Vitek, Inc. Test sample positioning system
AU715627B2 (en) 1996-02-21 2000-02-03 Biomerieux Vitek, Inc. Automatic sample testing machine
USD378782S (en) 1996-03-01 1997-04-08 Johnson & Johnson Clinical Diagnostics, Inc. Processor for nucleic acid detection
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
US5895762A (en) 1996-03-25 1999-04-20 Diasys Corporation Apparatus and method for handling fluid samples of body materials
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
US5844238A (en) 1996-03-27 1998-12-01 David Sarnoff Research Center, Inc. Infrared imager using room temperature capacitance sensor
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5671303A (en) 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US5948363A (en) 1996-04-22 1999-09-07 Gaillard; Patrick Micro-well strip with print tabs
US6001307A (en) 1996-04-26 1999-12-14 Kyoto Daiichi Kagaku Co., Ltd. Device for analyzing a sample
US6221672B1 (en) 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
US6180950B1 (en) 1996-05-14 2001-01-30 Don Olsen Micro heating apparatus for synthetic fibers
US6509193B1 (en) 1996-05-20 2003-01-21 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
US5726404A (en) 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US6083762A (en) 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system
US5914229A (en) 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US5912124A (en) 1996-06-14 1999-06-15 Sarnoff Corporation Padlock probe detection
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
AU726987B2 (en) 1996-06-28 2000-11-30 Caliper Life Sciences, Inc. Electropipettor and compensation means for electrophoretic bias
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US20020053399A1 (en) 1996-07-30 2002-05-09 Aclara Biosciences, Inc Methods for fabricating enclosed microchannel structures
US6558916B2 (en) 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
US6280967B1 (en) 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US5804436A (en) 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
FR2752226B1 (fr) 1996-08-08 1998-10-02 Tran Tho Dong Jean Emballage pourvu d'une enveloppe souple interne et son procede de fabrication
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5858187A (en) 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
US6110343A (en) 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
JP2001502319A (ja) 1996-10-15 2001-02-20 藤沢薬品工業株式会社 成長ホルモンの放出を促進するベンズオキセピン誘導体
US6500390B1 (en) 1996-10-17 2002-12-31 David A. Boulton Method for sealing and venting a microplate assembly
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
USD421653S (en) 1996-11-18 2000-03-14 Tekmar Company Housing for a laboratory instrument
DE19749011A1 (de) 1996-11-19 1998-05-20 Lang Volker Mikroventil
US6465257B1 (en) 1996-11-19 2002-10-15 Caliper Technologies Corp. Microfluidic systems
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
USD399959S (en) 1997-01-24 1998-10-20 Abbott Laboratories Housing for a device for measuring the concentration of an analyte in a sample of blood
US5772966A (en) 1997-01-24 1998-06-30 Maracas; George N. Assay dispensing apparatus
USD414271S (en) 1997-02-03 1999-09-21 Eli Lilly And Company Reaction vessel for combining chemicals
US5972694A (en) 1997-02-11 1999-10-26 Mathus; Gregory Multi-well plate
DE19707226A1 (de) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US5861563A (en) 1997-03-20 1999-01-19 Bayer Corporation Automatic closed tube sampler
US5964997A (en) 1997-03-21 1999-10-12 Sarnoff Corporation Balanced asymmetric electronic pulse patterns for operating electrode-based pumps
US5747666A (en) 1997-03-26 1998-05-05 Willis; John P. Point-of-care analyzer module
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5964995A (en) 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5993750A (en) 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
WO1998049548A1 (en) 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5997708A (en) 1997-04-30 1999-12-07 Hewlett-Packard Company Multilayer integrated assembly having specialized intermediary substrate
CA2287962C (en) 1997-05-02 2007-01-02 Gen-Probe Incorporated Reaction receptacle apparatus
US5980719A (en) 1997-05-13 1999-11-09 Sarnoff Corporation Electrohydrodynamic receptor
US6106685A (en) 1997-05-13 2000-08-22 Sarnoff Corporation Electrode combinations for pumping fluids
JP3469585B2 (ja) 1997-05-23 2003-11-25 ガメラ バイオサイエンス コーポレイション ミクロ流体工学システムでの流動運動を駆動するために向心的加速を使用するための装置および方法
US6613512B1 (en) 1997-06-09 2003-09-02 Caliper Technologies Corp. Apparatus and method for correcting for variable velocity in microfluidic systems
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
ES2249818T3 (es) 1997-06-09 2006-04-01 F. Hoffmann-La Roche Ag Dispositivo desechable despues de su uso en un proceso.
US6190619B1 (en) 1997-06-11 2001-02-20 Argonaut Technologies, Inc. Systems and methods for parallel synthesis of compounds
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
US5900130A (en) 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
US5959291A (en) 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
JP3191150B2 (ja) 1997-06-30 2001-07-23 株式会社アステックコーポレーション 採血管ラック
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US5827481A (en) 1997-07-31 1998-10-27 Hewlett-Packard Company Cartridge system for effecting sample acquisition and introduction
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5919711A (en) 1997-08-07 1999-07-06 Careside, Inc. Analytical cartridge
US5916522A (en) 1997-08-07 1999-06-29 Careside, Inc. Electrochemical analytical cartridge
US6156199A (en) 1997-08-11 2000-12-05 Zuk, Jr.; Peter Centrifugal filtration apparatus
WO1999009042A2 (en) 1997-08-13 1999-02-25 Cepheid Microstructures for the manipulation of fluid samples
US6368871B1 (en) 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US5916776A (en) 1997-08-27 1999-06-29 Sarnoff Corporation Amplification method for a polynucleotide
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
CA2300203A1 (en) 1997-09-02 1999-03-11 Caliper Technologies Corporation Microfluidic system with electrofluidic and electrothermal controls
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
CA2301557A1 (en) 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US6902703B2 (en) 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US5961925A (en) 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
US5993611A (en) 1997-09-24 1999-11-30 Sarnoff Corporation Capacitive denaturation of nucleic acid
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
DE69839294T2 (de) 1997-09-29 2009-04-09 F. Hoffmann-La Roche Ag Gerät zur Abscheidung magnetischer Teilchen
EP1029244A4 (en) 1997-10-02 2003-07-23 Aclara Biosciences Inc CAPILLAR ASSAY WITH SEPARATION OF FREE AND TIED SPECIES
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
EP1032824A4 (en) 1997-10-15 2003-07-23 Aclara Biosciences Inc LAMINATED MICROSTRUCTURE DEVICE AND MANUFACTURING METHOD THEREOF
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6132684A (en) 1997-10-31 2000-10-17 Becton Dickinson And Company Sample tube holder
DE69841255D1 (de) 1997-11-14 2009-12-03 Gen Probe Inc Arbeitsgerät zur Analyse
US6287831B1 (en) 1997-11-14 2001-09-11 California Institute Of Technology Cell lysis device
US6443011B1 (en) 1997-11-19 2002-09-03 Inoex Gmbh Device for detecting errors and/or measuring wall thickness in continuous strips or tubes made of plastic using ultrasonic signals
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
USD413677S (en) 1997-11-26 1999-09-07 Bayer Corporation Sample tube rack
US6123205A (en) 1997-11-26 2000-09-26 Bayer Corporation Sample tube rack
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
DE69805649T2 (de) 1997-12-06 2002-12-05 Dna Res Innovations Ltd Isolierung von nukleinsäuren
US6914137B2 (en) 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
AU758407B2 (en) 1997-12-24 2003-03-20 Cepheid Integrated fluid manipulation cartridge
AU2021099A (en) 1997-12-30 1999-07-19 Caliper Technologies Corporation Software for the display of chromatographic separation data
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
JP3551293B2 (ja) 1998-02-02 2004-08-04 東洋紡績株式会社 核酸抽出装置
USD413391S (en) 1998-02-05 1999-08-31 Bayer Corporation Test tube sample rack
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6861035B2 (en) 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
USD417009S (en) 1998-03-02 1999-11-23 Bayer Corporation Sample tube rack
USD428497S (en) 1998-03-06 2000-07-18 Bayer Corporation Test tube sample rack
US6024920A (en) 1998-04-21 2000-02-15 Bio-Rad Laboratories, Inc. Microplate scanning read head
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
ATE363339T1 (de) 1998-05-01 2007-06-15 Gen Probe Inc Rührvorrichtung für den fluiden inhalt eines behälters
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
JPH11316226A (ja) 1998-05-06 1999-11-16 Olympus Optical Co Ltd 自動測定用カートリッジ及び自動測定法
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
EP0964555A1 (de) 1998-06-04 1999-12-15 Siemens Aktiengesellschaft Pegelregelung und adaptive Filterung in CAP-Empfängern
US6274089B1 (en) 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6149882A (en) 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
USD421130S (en) 1998-06-15 2000-02-22 Bayer Corporation Sample tube rack
US7799521B2 (en) 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
USD420747S (en) 1998-07-10 2000-02-15 Bayer Corporation Sample tube rack
DE19833087A1 (de) 1998-07-23 2000-01-27 Bosch Gmbh Robert Gassensor und Verfahren zu dessen Herstellung
DE19833293C1 (de) 1998-07-24 2000-01-20 Gunther Botsch Trennvorrichtung
US6366924B1 (en) 1998-07-27 2002-04-02 Caliper Technologies Corp. Distributed database for analytical instruments
ATE303598T1 (de) 1998-07-31 2005-09-15 Tecan Trading Ag Magnetseparator
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6236456B1 (en) 1998-08-18 2001-05-22 Molecular Devices Corporation Optical system for a scanning fluorometer
US6316774B1 (en) 1998-08-18 2001-11-13 Molecular Devices Corporation Optical system for a scanning fluorometer
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
USD439673S1 (en) 1998-10-06 2001-03-27 Sorenson Bioscience Multi-well microcentrifuge tube
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6958392B2 (en) 1998-10-09 2005-10-25 Whatman, Inc. Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
US6498497B1 (en) 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6948843B2 (en) 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US5973138A (en) 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
JP2000180455A (ja) 1998-12-15 2000-06-30 Sanuki Kogyo Kk フローインジェクション自動分析装置
US6062261A (en) 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US6887693B2 (en) 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ， エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US6150119A (en) 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
IT1306964B1 (it) 1999-01-19 2001-10-11 St Microelectronics Srl Circuito a boosting capacitivo per la regolazione della tensione dilettura di riga in memorie non-volatili
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020019059A1 (en) 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
WO2000046594A1 (en) 1999-02-02 2000-08-10 Caliper Technologies Corp. Methods, devices and systems for characterizing proteins
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
EP1163052B1 (en) 1999-02-23 2010-06-02 Caliper Life Sciences, Inc. Manipulation of microparticles in microfluidic systems
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6558945B1 (en) 1999-03-08 2003-05-06 Aclara Biosciences, Inc. Method and device for rapid color detection
US6148508A (en) 1999-03-12 2000-11-21 Caliper Technologies Corp. Method of making a capillary for electrokinetic transport of materials
JP2000266760A (ja) 1999-03-17 2000-09-29 Hitachi Ltd 分注装置
EP1041386B1 (en) 1999-03-25 2007-10-17 Tosoh Corporation Analyzer
JP3988306B2 (ja) 1999-03-25 2007-10-10 東ソー株式会社 自動測定装置
US6194563B1 (en) 1999-03-26 2001-02-27 Vysis, Inc. Solid phase nucleic acid labeling by transamination
US6783962B1 (en) 1999-03-26 2004-08-31 Upfront Chromatography Particulate material for purification of bio-macromolecules
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6306273B1 (en) 1999-04-13 2001-10-23 Aclara Biosciences, Inc. Methods and compositions for conducting processes in microfluidic devices
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
CA2270106C (en) 1999-04-23 2006-03-14 Yousef Haj-Ahmad Nucleic acid purification and process
US6773676B2 (en) 1999-04-27 2004-08-10 Agilent Technologies, Inc. Devices for performing array hybridization assays and methods of using the same
ATE419528T1 (de) 1999-04-28 2009-01-15 Eidgenoess Tech Hochschule Polyionische beschichtungen für analytische und sensor-vorrichtungen
US6458259B1 (en) 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
US6399952B1 (en) 1999-05-12 2002-06-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6838680B2 (en) 1999-05-12 2005-01-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6326147B1 (en) 1999-05-13 2001-12-04 The Perkin-Elmer Corporation Methods, apparatus, articles of manufacture, and user interfaces for performing automated biological assay preparation and macromolecule purification
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
AU770678B2 (en) 1999-05-17 2004-02-26 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
WO2000073413A2 (en) 1999-05-28 2000-12-07 Cepheid Apparatus and method for cell disruption
WO2001012325A1 (en) 1999-05-28 2001-02-22 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
WO2000072970A1 (en) 1999-05-28 2000-12-07 Cepheid Cartridge for conducting a chemical reaction
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6649358B1 (en) 1999-06-01 2003-11-18 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
DE29909529U1 (de) 1999-06-01 1999-08-12 Festo Ag & Co Fluidtechnisches Steuergerät
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
FR2795426A1 (fr) 1999-06-22 2000-12-29 Commissariat Energie Atomique Support d'analyse biologique a amplification
CA2721172C (en) 1999-06-28 2012-04-10 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
AU6068300A (en) 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
US6353475B1 (en) 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
AU777180B2 (en) 1999-07-19 2004-10-07 Organon Teknika B.V. Device and method for mixing magnetic particles with a fluid
USD438311S1 (en) 1999-07-28 2001-02-27 Matsushita Electric Industrial Co.,Ltd. Strip for blood test
US6337435B1 (en) 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6818060B2 (en) 1999-08-02 2004-11-16 Emerald Biostructures, Inc. Robot for mixing crystallization trial matrices
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
EP1077086B1 (en) 1999-08-18 2004-10-27 Becton Dickinson and Company Stopper-shield assembly
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
WO2001014931A1 (en) 1999-08-23 2001-03-01 Mitsubishi Chemical Corporation Photopolymerizable composition and photopolymerizable lithographic plate
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6824663B1 (en) 1999-08-27 2004-11-30 Aclara Biosciences, Inc. Efficient compound distribution in microfluidic devices
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
AU7101000A (en) 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
USD466219S1 (en) 1999-09-13 2002-11-26 Micronic B.V. Carrier for test-tubes
US6906797B1 (en) 1999-09-13 2005-06-14 Aclara Biosciences, Inc. Side light activated microfluid channels
DE19945604A1 (de) 1999-09-23 2003-08-07 Aclara Biosciences Inc Verfahren zur Verbindung von Werkstücken aus Kunststoff und seine Verwendung in der Mikro- und Nanostrukturtechnik
US6221600B1 (en) 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
DE19948473A1 (de) 1999-10-08 2001-04-12 Nmi Univ Tuebingen Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen
AU783191B2 (en) 1999-10-08 2005-10-06 Caliper Life Sciences, Inc. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US6232072B1 (en) 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6287254B1 (en) 1999-11-02 2001-09-11 W. Jean Dodds Animal health diagnosis
US6908594B1 (en) 1999-10-22 2005-06-21 Aclara Biosciences, Inc. Efficient microfluidic sealing
USD461906S1 (en) 1999-10-25 2002-08-20 Tuan Hung Pham Diagnostic test card
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
CA2393690A1 (en) 1999-12-09 2001-06-14 Huinan Yu Multilayered microfluidic devices for analyte reactions
USD438632S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Multi-well reagent cartridge for treating a sample
USD438633S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Reagent cartridge for treating a sample
US6936414B2 (en) 1999-12-22 2005-08-30 Abbott Laboratories Nucleic acid isolation method and kit
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6379884B2 (en) 2000-01-06 2002-04-30 Caliper Technologies Corp. Methods and systems for monitoring intracellular binding reactions
US6620625B2 (en) 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
EP1246699B1 (en) 2000-01-11 2007-01-03 Clinical Micro Sensors, Inc. Cartridge comprising a biochip
WO2001051918A1 (en) 2000-01-12 2001-07-19 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
JP3397737B2 (ja) 2000-01-24 2003-04-21 倉敷紡績株式会社 核酸の抽出方法
US6556923B2 (en) 2000-01-26 2003-04-29 Caliper Technologies Corp. Software for high throughput microfluidic systems
US6589729B2 (en) 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US6685813B2 (en) 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
AU2001234997B2 (en) 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
JP3750460B2 (ja) 2000-02-18 2006-03-01 日立工機株式会社 分注装置及び分注方法
CA2400644C (en) 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7040144B2 (en) 2000-02-23 2006-05-09 Caliper Life Sciences, Inc. Microfluidic viscometer
US6681616B2 (en) 2000-02-23 2004-01-27 Caliper Technologies Corp. Microfluidic viscometer
JP2003524183A (ja) 2000-02-23 2003-08-12 カリパー・テクノロジーズ・コープ． マルチリザーバ圧力コントロールシステム
US20020072060A1 (en) 2000-07-19 2002-06-13 Getts Robert C. Methods for detecting and assaying nucleic acid sequences
AU2001249253A1 (en) 2000-03-17 2001-10-03 Aclara Biosciences, Inc. Microfluidic device and system with improved sample handling
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US6927851B2 (en) 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6401552B1 (en) 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
USD446306S1 (en) 2000-04-26 2001-08-07 Matsushita Electric Industrial Co., Ltd. Medical information communication apparatus
US6787016B2 (en) 2000-05-01 2004-09-07 Aclara Biosciences, Inc. Dynamic coating with linear polymer mixture for electrophoresis
ATE503209T1 (de) 2000-05-03 2011-04-15 Caliper Life Sciences Inc Herstellungsprozesse für substrate mit mehreren tiefen
AU2001261541B2 (en) 2000-05-11 2004-10-14 Caliper Life Sciences, Inc. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
EP1297179B1 (en) 2000-05-12 2008-09-24 Caliper Life Sciences, Inc. Detection of nucleic acid hybridization by fluorescence polarization
US6672458B2 (en) 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
ATE419919T1 (de) 2000-05-19 2009-01-15 Becton Dickinson Co System und verfahren zur behandlung von magnetpartikeln in test-flüssigkeiten zum sammeln von dna und rna
DE60134849D1 (de) 2000-05-19 2008-08-28 Aclara Biosciences Inc Ausrichtung eines optischen detektionssystems mit einem kapillarkanal in einem mikrofluiden laborchip
WO2001089681A2 (en) 2000-05-24 2001-11-29 Cellular Process Chemistry, Inc. Modular chemical production system incorporating a microreactor
US6520197B2 (en) 2000-06-02 2003-02-18 The Regents Of The University Of California Continuous laminar fluid mixing in micro-electromechanical systems
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
ATE304174T1 (de) 2000-06-14 2005-09-15 Univ Texas Systeme und verfahren zur zellteilbevölkerungsanalyse
EP1311346A4 (en) 2000-06-19 2003-07-30 Caliper Techn Corp METHOD AND DEVICES FOR INCREASING THE TIED SUBSTRATE EXPLOITATION AND TEMPERATURE CONTROL
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
EP1305615B1 (en) 2000-07-21 2004-09-29 Aclara BioSciences, Inc. Method and devices for capillary electrophoresis with a norbornene based surface coating
FR2812088B1 (fr) 2000-07-21 2003-01-24 Abx Sa Dispositif de traitement d'echantillons de produits sanguins
US7004184B2 (en) 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
AU8095101A (en) 2000-08-02 2002-02-13 Caliper Techn Corp High throughput separations based analysis systems
US20020142618A1 (en) 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
FR2813207B1 (fr) 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
JP3993372B2 (ja) 2000-09-13 2007-10-17 独立行政法人理化学研究所 リアクタの製造方法
DE60140553D1 (de) 2000-09-14 2009-12-31 Caliper Life Sciences Inc MIKROFLUIDISCHE VORRICHTUNGEN UND METHODEN UM TEMPERATUR-VERMITTELTE REAKTIONEN DURCHZUFüHREN
EP1334347A1 (en) 2000-09-15 2003-08-13 California Institute Of Technology Microfabricated crossflow devices and methods
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
USD463031S1 (en) 2000-10-11 2002-09-17 Aclara Biosciences, Inc. Microvolume sample plate
GB2384309B8 (en) 2000-10-13 2016-03-02 Irm Llc High throughput processing system and method of using
US6375185B1 (en) 2000-10-20 2002-04-23 Gamemax Corporation Paper currency receiving control assembly for currency-coin exchange machine
ATE432466T1 (de) 2000-10-31 2009-06-15 Caliper Life Sciences Inc Mikrofluidisches verfahren für in-situ- materialkonzentration
US7514046B2 (en) 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
US7105304B1 (en) 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US20050202470A1 (en) 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
CH695544A5 (de) 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
USD468437S1 (en) 2000-11-21 2003-01-07 Acon Laboratories, Inc. Test platform
US6521188B1 (en) 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US7024281B1 (en) 2000-12-11 2006-04-04 Callper Life Sciences, Inc. Software for the controlled sampling of arrayed materials
US6382254B1 (en) 2000-12-12 2002-05-07 Eastman Kodak Company Microfluidic valve and method for controlling the flow of a liquid
US6453928B1 (en) 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
JP4505776B2 (ja) 2001-01-19 2010-07-21 凸版印刷株式会社 遺伝子検出システム、これを備えた遺伝子検出装置、検出方法、並びに遺伝子検出用チップ
US6878755B2 (en) 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
JP3548858B2 (ja) 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 流量の制御方法及びそれに用いるマイクロバルブ
US6681788B2 (en) 2001-01-29 2004-01-27 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7867776B2 (en) 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
JP4148778B2 (ja) 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US20140227710A1 (en) 2001-03-28 2014-08-14 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US20020143297A1 (en) 2001-03-30 2002-10-03 Becton, Dickinson And Company Adaptor for use with point-of-care testing cartridge
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
USD500142S1 (en) 2001-04-10 2004-12-21 Andrea Crisanti Assay device
USD470595S1 (en) 2001-04-10 2003-02-18 Andrea Crisanti Assay device
US7440684B2 (en) 2001-04-12 2008-10-21 Spaid Michael A Method and apparatus for improved temperature control in microfluidic devices
US20020155010A1 (en) 2001-04-24 2002-10-24 Karp Christoph D. Microfluidic valve with partially restrained element
US6588625B2 (en) 2001-04-24 2003-07-08 Abbott Laboratories Sample handling system
USD495805S1 (en) 2001-05-25 2004-09-07 Umedik, Inc. Assay device
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020187557A1 (en) 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
US6859698B2 (en) 2001-06-21 2005-02-22 Snap-On Incorporated Detachable cartridge unit and auxiliary unit for function expansion of a data processing system
US20030211517A1 (en) 2001-06-22 2003-11-13 Carulli John P. Gp354 nucleic acids and polypeptides
US6709857B2 (en) 2001-06-26 2004-03-23 Becton, Dickinson And Company System and method for optically monitoring the concentration of a gas in a sample vial using photothermal spectroscopy to detect sample growth
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
WO2003006964A1 (en) 2001-07-12 2003-01-23 Aclara Biosciences, Inc. Submersible light-directing member for material excitation in microfluidic devices
US20040209331A1 (en) 2001-07-16 2004-10-21 Kirk Ririe Thermal cycling system and method of use
US7023007B2 (en) 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
US20030064507A1 (en) 2001-07-26 2003-04-03 Sean Gallagher System and methods for mixing within a microfluidic device
WO2003012406A1 (en) 2001-07-26 2003-02-13 Handylab, Inc. Methods and systems for microfluidic processing
US20060062696A1 (en) 2001-07-27 2006-03-23 Caliper Life Sciences, Inc. Optimized high throughput analytical systems
US7060171B1 (en) 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
JP2003047839A (ja) 2001-08-06 2003-02-18 Yamatake Corp マイクロリアクタ
JP2003047840A (ja) 2001-08-06 2003-02-18 Yamatake Corp マイクロリアクタ
US6640981B2 (en) 2001-08-14 2003-11-04 3088081 Canada Inc. Modular test tube rack
USD482796S1 (en) 2001-09-11 2003-11-25 Sysmex Corporation Sample analyzer
USD512155S1 (en) 2001-09-12 2005-11-29 Techno Medica Co., Ltd. Automatic blood sampling tube preparation apparatus
JP3996416B2 (ja) 2001-09-21 2007-10-24 Ｊｕｋｉ株式会社 核酸ハイブリダイゼーションにおけるｂ／ｆ分離方法
US20030059823A1 (en) 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
USD467349S1 (en) 2001-09-28 2002-12-17 Orasure Technologies, Inc. Analyzer
USD467348S1 (en) 2001-10-15 2002-12-17 Kimberly-Clark Worldwide, Inc. Diagnostic test carrier
US7220345B2 (en) 2001-10-18 2007-05-22 The Board Of Trustees Of The University Of Illinois Hybrid microfluidic and nanofluidic system
US20030156991A1 (en) 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US6750661B2 (en) 2001-11-13 2004-06-15 Caliper Life Sciences, Inc. Method and apparatus for controllably effecting samples using two signals
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
DE10156790A1 (de) 2001-11-19 2003-06-18 Chemagen Biopolymer Technologi Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln
US20030099954A1 (en) 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
EP1463796B1 (en) 2001-11-30 2013-01-09 Fluidigm Corporation Microfluidic device and methods of using same
US6960235B2 (en) 2001-12-05 2005-11-01 The Regents Of The University Of California Chemical microreactor and method thereof
JP2003185584A (ja) 2001-12-18 2003-07-03 Fuji Photo Film Co Ltd スキャナ
DE10163476A1 (de) 2001-12-21 2003-10-30 Siemens Ag Anordnung zur Trennung einer Komponente aus einem Fluid
US20030127327A1 (en) 2002-01-04 2003-07-10 Kurnik Ronald T. Microfluidic device and method for improved sample handling
US7410615B2 (en) 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7205154B2 (en) 2002-01-31 2007-04-17 Agilent Technologies, Inc. Calibrating array scanners
US7288228B2 (en) 2002-02-12 2007-10-30 Gilson, Inc. Sample injection system
US6819027B2 (en) 2002-03-04 2004-11-16 Cepheid Method and apparatus for controlling ultrasonic transducer
US7101467B2 (en) 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
WO2003076052A1 (en) 2002-03-05 2003-09-18 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US7195986B1 (en) 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
KR100450818B1 (ko) 2002-03-09 2004-10-01 삼성전자주식회사 다챔버 ｐｃｒ 칩
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
CA2422224A1 (en) 2002-03-15 2003-09-15 Affymetrix, Inc. System, method, and product for scanning of biological materials
DE10212761B4 (de) 2002-03-22 2009-12-31 Eppendorf Ag Mikrotiterplatte
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
CA2480200A1 (en) 2002-04-02 2003-10-16 Caliper Life Sciences, Inc. Methods and apparatus for separation and isolation of components from a biological sample
USD472324S1 (en) 2002-04-05 2003-03-25 Charles River Laboratories, Inc. Cuvette
JP2003299485A (ja) 2002-04-10 2003-10-21 Sekisui Chem Co Ltd 温度制御型マイクロリアクター及びマイクロリアクターシステム
AU2003228514A1 (en) 2002-04-11 2003-10-27 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US8241883B2 (en) 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
US6905612B2 (en) 2003-03-21 2005-06-14 Hanuman Llc Plasma concentrate apparatus and method
JP3972189B2 (ja) 2002-05-10 2007-09-05 日本パルスモーター株式会社 着脱自在なカートリッジラック構造を備える分注装置
JP3839349B2 (ja) 2002-05-15 2006-11-01 株式会社堀場製作所 化学発光酵素免疫測定装置
USD474279S1 (en) 2002-05-15 2003-05-06 Monogen, Inc. Specimen processing instrument
WO2003097808A2 (en) 2002-05-17 2003-11-27 Becton, Dickinson And Company Automated system for isolating, amplyifying and detecting a target nucleic acid sequence
WO2003097239A1 (en) 2002-05-17 2003-11-27 Gen-Probe Incorporated Sample carrier having releasable locking mechanism
ATE337097T1 (de) 2002-05-17 2006-09-15 Gen Probe Inc Probenträger mit feststelleinrichtung und zugehörige tropfschirmvorrichtung
EP1507592A1 (de) 2002-05-24 2005-02-23 EPR Labautomation AG Verfahren und vorrichtung zum dosieren kleiner flüssigkeitsvolumen
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
USD480814S1 (en) 2002-06-11 2003-10-14 Diversa Corporation Gigamatrix holding tray
US7208125B1 (en) 2002-06-28 2007-04-24 Caliper Life Sciences, Inc Methods and apparatus for minimizing evaporation of sample materials from multiwell plates
ATE529188T1 (de) 2002-07-15 2011-11-15 Phynexus Inc Extraktionskolonnenvorrichtung
US7438857B2 (en) 2002-07-23 2008-10-21 Protedyne Corporation Liquid handling tool having porous plunger
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
WO2004010760A2 (en) 2002-07-26 2004-02-05 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
US7214348B2 (en) 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
DE10236029A1 (de) 2002-08-02 2004-02-19 Cybio Systems Gmbh Einrichtung zum Dispensieren und Beobachten der Lumineszenz von Einzelproben in Multiprobenanordnungen
US20040053315A1 (en) 2002-08-12 2004-03-18 Caliper Technologies Corp. Methods and systems for monitoring molecular interactions
GB0219457D0 (en) 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
US7001853B1 (en) 2002-08-30 2006-02-21 Caliper Life Sciences, Inc. Flow control of photo-polymerizable resin
USD516221S1 (en) 2002-09-09 2006-02-28 Meso Scale Technologies, Llc. Diagnostic instrument
ITTO20020808A1 (it) 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
JP3756477B2 (ja) 2002-09-17 2006-03-15 横河電機株式会社 デンドリマーによる核酸またはタンパク質の抽出方法およびデンドリマー組成物
USD484989S1 (en) 2002-09-20 2004-01-06 Dade Behring Inc. Multi-well liquid container
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
WO2004034028A2 (en) 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
US7932098B2 (en) 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
AU2003291439A1 (en) 2002-11-08 2004-06-03 Irm, Llc Apparatus and methods to process substrate surface features
JP2004170159A (ja) 2002-11-18 2004-06-17 Hitachi Koki Co Ltd 自動分注装置
WO2004048545A2 (en) 2002-11-26 2004-06-10 University Of Massachusetts DELIVERY OF siRNAs______________________________________________
USD491276S1 (en) 2002-12-09 2004-06-08 Babette Langille Plastic diagnostic card
USD491272S1 (en) 2002-12-13 2004-06-08 Immunivest Corporation Autoprep instrument
US6905583B2 (en) 2002-12-13 2005-06-14 Aclara Biosciences, Inc. Closed-loop control of electrokinetic processes in microfluidic devices based on optical readings
SE0203781D0 (sv) 2002-12-19 2002-12-19 Alphahelix Ab Holder and method for cooling or heating samples
USD491273S1 (en) 2002-12-19 2004-06-08 3M Innovative Properties Company Hybridization cartridge
JP4395133B2 (ja) 2002-12-20 2010-01-06 カリパー・ライフ・サイエンシズ・インク． Ｄｎａの単一分子増幅および検出
US20060094108A1 (en) 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20050042639A1 (en) 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
CA2941139C (en) 2002-12-26 2021-07-20 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US20060113190A1 (en) 2002-12-27 2006-06-01 Kurnik Ronald T Microfluidic device and method for improved sample handling
US7445926B2 (en) 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
US20070269891A9 (en) 2003-01-13 2007-11-22 Yasunobu Tanaka Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US6964747B2 (en) 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
US7049558B2 (en) 2003-01-27 2006-05-23 Arcturas Bioscience, Inc. Apparatus and method for heating microfluidic volumes and moving fluids
JP4021335B2 (ja) 2003-01-31 2007-12-12 ユニバーサル・バイオ・リサーチ株式会社 監視機能付分注装置および分注装置の監視方法
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
EP2574400B1 (en) 2003-02-05 2016-09-28 Iquum, Inc. Sample processing
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
KR100959101B1 (ko) 2003-02-20 2010-05-25 삼성전자주식회사 Ｐｃｒ 반응기 및 ｐｃｒ 반응기의 입구와 출구의 개폐를조절하는 방법
WO2004076056A2 (en) 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
JP2004305009A (ja) 2003-04-02 2004-11-04 Hitachi Ltd 核酸増幅装置及び核酸増幅方法
CA2521539A1 (en) 2003-04-08 2004-10-28 Irm, Llc Material removal and dispensing devices, systems, and methods
EP1613962B1 (en) 2003-04-14 2008-10-29 Caliper Life Sciences, Inc. Reduction of migration shift assay interference
US7820030B2 (en) 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
GB2401237A (en) 2003-04-28 2004-11-03 Hewlett Packard Development Co Data transfer arrangement for disaster recovery
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP4156627B2 (ja) 2003-05-09 2008-09-24 カリパー・ライフ・サイエンシズ・インコーポレーテッド 自動サンプル分析
US7038472B1 (en) 2003-05-12 2006-05-02 Caliper Life Sciences, Inc. Methods and systems for measuring internal dimensions of microscale structures
US7374949B2 (en) 2003-05-29 2008-05-20 Bayer Healthcare Llc Diagnostic test strip for collecting and detecting an analyte in a fluid sample
US7055695B2 (en) 2003-06-02 2006-06-06 Caliper Life Sciencee, Inc. Container providing a controlled hydrated environment
JP2005009870A (ja) 2003-06-16 2005-01-13 Fuji Photo Film Co Ltd 分析装置の吸引方法
WO2005008255A1 (ja) 2003-07-17 2005-01-27 Mitsubishi Kagaku Iatron, Inc. 自動測定用カートリッジおよびそれを用いる測定装置
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
EP1648622A4 (en) 2003-07-21 2009-11-11 Dendritic Nanotechnologies Inc STABILIZED AND CHEMICALLY FUNCTIONALIZED NANOPARTICLES
USD500363S1 (en) 2003-07-24 2004-12-28 Biomerieux Inc. Sample holder
USD508999S1 (en) 2003-07-24 2005-08-30 Biomerieux, Inc. Sample testing machine
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
USD499813S1 (en) 2003-08-22 2004-12-14 As.Pire Bioresearch Inc. Assay testing device
JP2005065607A (ja) 2003-08-26 2005-03-17 Hitachi Ltd 遺伝子処理チップおよび遺伝子処理装置
USD515707S1 (en) 2003-09-01 2006-02-21 Matsushita Electric Industrial Co., Ltd. Fluorescent reader
WO2005024411A2 (en) 2003-09-05 2005-03-17 Caliper Life Sciences, Inc. Analyte injection system
US7501094B2 (en) 2003-09-15 2009-03-10 Syngenta Limited Preparation and characterization of formulations in a high throughput mode
CA2539131A1 (en) 2003-09-19 2005-03-31 University Of Rochester Diagnostic system for otolaryngologic pathogens and use thereof
US20050220675A1 (en) 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20050069898A1 (en) 2003-09-25 2005-03-31 Cepheid Lyophilized beads containing mannitol
DE10344700A1 (de) 2003-09-26 2005-04-14 Hirschmann Laborgeräte GmbH & Co. KG Mehrkanal-Pipettiervorrichtung
JP2007506439A (ja) 2003-09-26 2007-03-22 データスコープ・インベストメント・コーポレイション 少量の核酸を合成する方法
EP1673608A4 (en) 2003-09-29 2008-05-07 Vision Biosystems Ltd SYSTEM AND METHOD FOR PROCESSING HISTOLOGICAL TISSUE SPECIMENS
USD528215S1 (en) 2003-09-30 2006-09-12 Biacore Ab Chip carrier for biosensor
WO2005033672A1 (en) 2003-10-01 2005-04-14 Caliper Life Sciences, Inc. Method for measuring diffusivities of compounds using microfluidic devices
NL1024578C2 (nl) 2003-10-21 2005-04-22 Univ Delft Tech Inrichting voor het uitvoeren van een reactie.
US7780639B2 (en) 2003-11-12 2010-08-24 Van Lue Stephen J Magnetic devices and apparatus for medical/surgical procedures and methods for using same
US7754500B2 (en) 2003-11-21 2010-07-13 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
EP1541237A3 (en) 2003-12-10 2006-02-01 Samsung Electronics Co., Ltd. Polymerase chain reaction (pcr) module and multiple pcr system using the same
JP4595446B2 (ja) 2003-12-12 2010-12-08 Ｄｉｃ株式会社 核酸増幅方法
JP2005176613A (ja) 2003-12-16 2005-07-07 Yokogawa Electric Corp デンドリマー利用のｄｎａ抽出方法およびバイオチップ
CN100562745C (zh) 2003-12-23 2009-11-25 卡钳生命科学股份有限公司 分析物注射系统
JP4750412B2 (ja) 2003-12-25 2011-08-17 モレックス インコーポレイテド 生体由来分子、ダイオキシン類及び内分泌撹乱物質検出装置及び当該装置を使用した検出方法
KR100750586B1 (ko) 2003-12-26 2007-08-20 한국전자통신연구원 미소유체 가열 시스템
JP4732683B2 (ja) 2003-12-29 2011-07-27 ユニバーサル・バイオ・リサーチ株式会社 標的物質の検出方法
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
WO2005072353A2 (en) 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
US7618811B2 (en) 2004-02-24 2009-11-17 Thermal Gradient Thermal cycling device
US20050196321A1 (en) 2004-03-03 2005-09-08 Zhili Huang Fluidic programmable array devices and methods
USD517554S1 (en) 2004-03-05 2006-03-21 Seiko Epson Corporation Film scanner
KR100552706B1 (ko) 2004-03-12 2006-02-20 삼성전자주식회사 핵산 증폭 방법 및 장치
WO2005091993A2 (en) 2004-03-19 2005-10-06 Espir Kahatt Device for aspirating, manipulating, mixing and dispensing nano-volumes of liquids
JP3858029B2 (ja) * 2004-03-22 2006-12-13 株式会社アイディエス 試験管の検知装置
JP2005291954A (ja) * 2004-03-31 2005-10-20 Olympus Corp 使い捨て試薬パックとその試薬パックを用いる分析装置
CN101035620B (zh) 2004-04-08 2012-01-04 生物马特里卡公司 用于生命科学的样品存储和样品管理的综合
ATE497837T1 (de) 2004-04-09 2011-02-15 Vivebio Llc Vorrichtungen und verfahren für abnahme, lagerung und transport von biologischen proben
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
AU2005241080B2 (en) 2004-05-03 2011-08-11 Handylab, Inc. Processing polynucleotide-containing samples
JP4784508B2 (ja) 2004-05-07 2011-10-05 コニカミノルタエムジー株式会社 検査用マイクロリアクタおよび検査装置ならびに検査方法
GB2414059B (en) 2004-05-10 2008-06-11 E2V Tech Uk Ltd Microfluidic device
JP3952036B2 (ja) 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
WO2005114223A2 (en) 2004-05-21 2005-12-01 Caliper Life Sciences, Inc. Automat system for handling microfluidic devices
US7553671B2 (en) 2004-05-25 2009-06-30 Vertex Pharmaceuticals, Inc. Modular test tube rack
WO2005116202A1 (ja) 2004-05-27 2005-12-08 Universal Bio Research Co., Ltd. 反応容器、反応測定装置、および液回転処理装置
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
CA2569745A1 (en) 2004-06-07 2005-12-22 Irm Llc Dispensing systems, software, and related methods
US7480042B1 (en) 2004-06-30 2009-01-20 Applied Biosystems Inc. Luminescence reference standards
US8965710B2 (en) 2004-07-02 2015-02-24 The United States Of America, As Represented By The Secretary Of The Navy Automated sample-to-microarray apparatus and method
JP4440020B2 (ja) 2004-07-09 2010-03-24 株式会社神戸製鋼所 マイクロ反応器及びその製造方法
USD523153S1 (en) 2004-07-23 2006-06-13 Hitachi High-Technologies Corporation Main part for immunity analysis machine
EP1621890A1 (en) 2004-07-26 2006-02-01 bioMerieux B.V. Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
KR100668304B1 (ko) 2004-09-16 2007-01-12 삼성전자주식회사 Ｐｃｒ 혼합액을 ｐｃｒ 칩의 각 ｐｃｒ 채널에 주입하기위한 장치 및 상기 장치를 포함하는 ｐｃｒ 칩 유니트
JP4621846B2 (ja) 2004-09-30 2011-01-26 アークレイ株式会社 分析用具
USD548841S1 (en) 2004-10-15 2007-08-14 Microsulis, Ltd Electrical equipment for ablative treatment
JPWO2006043642A1 (ja) 2004-10-20 2008-05-22 株式会社荏原製作所 流体反応装置
JP2006145458A (ja) 2004-11-24 2006-06-08 Yaskawa Electric Corp 分注装置
US7727477B2 (en) 2004-12-10 2010-06-01 Bio-Rad Laboratories, Inc. Apparatus for priming microfluidics devices with feedback control
JP4573243B2 (ja) 2004-12-15 2010-11-04 小林クリエイト株式会社 試験管用トレイ
KR101263173B1 (ko) 2004-12-17 2013-05-13 닛토덴코 가부시키가이샤 진핵 세포의 트랜스펙션을 위한 고정화된 분해가능한양이온성 중합체
US20060165558A1 (en) 2004-12-21 2006-07-27 Thomas Witty Cartridge for diagnostic assays
US20060183216A1 (en) 2005-01-21 2006-08-17 Kalyan Handique Containers for liquid storage and delivery with application to microfluidic devices
US7964380B2 (en) 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
DE102005004664B4 (de) 2005-02-02 2007-06-21 Chemagen Biopolymer-Technologie Aktiengesellschaft Vorrichtung und Verfahren und Verwendung zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit sowie deren Verwendungen
WO2006089252A2 (en) 2005-02-16 2006-08-24 Mcneely Michael R Liquid valving using reactive or responsive materials
ATE538213T1 (de) 2005-02-18 2012-01-15 Canon Us Life Sciences Inc Vorrichtung und verfahren zum identifizieren genomischer dna von organismen
USD535403S1 (en) 2005-02-25 2007-01-16 Fuji Photo Film Co., Ltd. Component extractor for biochemistry
CA2600934A1 (en) 2005-03-07 2006-09-14 Novx Systems Inc. Automated analyzer
ZA200707354B (en) 2005-03-08 2009-04-29 Authentix Inc Microfluidic device for identification, quantification, and authentication of latent markers
US7932081B2 (en) 2005-03-10 2011-04-26 Gen-Probe Incorporated Signal measuring system for conducting real-time amplification assays
US20060228734A1 (en) 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
JP4525427B2 (ja) 2005-04-01 2010-08-18 パナソニック株式会社 分析ディスク、並びに分析ディスクおよび分析装置の検査方法
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US9097723B2 (en) 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
CA112854S (en) 2005-04-10 2007-03-27 Akubio Ltd Microbalance analyser cartridge
WO2006115863A2 (en) 2005-04-12 2006-11-02 Caliper Life Sciences, Inc. Compact optical detection system for microfluidic devices
US20060234251A1 (en) 2005-04-19 2006-10-19 Lumigen, Inc. Methods of enhancing isolation of RNA from biological samples
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
USD566291S1 (en) 2005-05-03 2008-04-08 Handylab, Inc. Microfluidic cartridge
EP1896610A2 (en) 2005-05-03 2008-03-12 Handylab, Inc. Lyophilized pellets
USD534280S1 (en) 2005-05-04 2006-12-26 Abbott Laboratories Reagent carrier for use in an automated analyzer
EP1877190A1 (en) 2005-05-06 2008-01-16 Caliper Life Sciences, Inc. Microtitre plate with a relieved perimeter
WO2006122311A2 (en) 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Microfluidic chip
US8273294B2 (en) 2005-07-01 2012-09-25 Honeywell International Inc. Molded cartridge with 3-D hydrodynamic focusing
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
EP1904232A2 (en) 2005-07-07 2008-04-02 Inverness Medical Switzerland GmbH A method of performing a test, a support instrument and a microliquid system comprising such support instrument
US20070020699A1 (en) 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
US20070020764A1 (en) 2005-07-20 2007-01-25 Miller Kerry L Method for processing chemistry and coagulation test samples in a laboratory workcell
WO2007024778A2 (en) 2005-08-22 2007-03-01 Applera Corporation Device, system and method for depositing processed immiscible-fluid-discrete-volumes
JP2007074960A (ja) 2005-09-13 2007-03-29 Shimadzu Corp 遺伝子増幅法
USD549827S1 (en) 2005-09-16 2007-08-28 Horiba, Ltd. Blood analyzer
WO2007041619A2 (en) 2005-09-30 2007-04-12 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
JP4630786B2 (ja) 2005-10-04 2011-02-09 キヤノン株式会社 生化学処理装置、ｄｎａ増幅精製装置、該装置を含むｄｎａ検査装置
JP4827483B2 (ja) 2005-10-04 2011-11-30 キヤノン株式会社 核酸試料処理装置
US20070199821A1 (en) 2005-10-05 2007-08-30 Chow Andrea W Automated two-dimensional gel electrophoresis
US7727371B2 (en) 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
WO2007044917A2 (en) 2005-10-11 2007-04-19 Handylab, Inc. Polynucleotide sample preparation device
DE102005049920A1 (de) 2005-10-17 2007-04-19 Manz Automation Ag Roboteranordnung
USD537951S1 (en) 2005-10-21 2007-03-06 Sanyo Electric Co., Ltd. Gene amplification apparatus
USD556914S1 (en) 2005-10-21 2007-12-04 Sanyo Electric Co., Ltd. Gene amplification apparatus
US20070092403A1 (en) 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
DE102005051850A1 (de) 2005-10-28 2007-05-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Vervielfältigung und Detektion von Nukleinsäuren
US20070104617A1 (en) 2005-11-04 2007-05-10 Advanced Biotechnologies Limited Capped tubes
US20070116613A1 (en) 2005-11-23 2007-05-24 Donat Elsener Sample tube and system for storing and providing nucleic acid samples
EP2283923A2 (en) 2005-11-30 2011-02-16 F. Hoffmann-La Roche AG Linear cuvette array without positioning means
WO2007064117A1 (en) 2005-11-30 2007-06-07 Electronics And Telecommunications Research Institute Affinity chromatography microdevice and method for manufacturing the same
JP3899360B2 (ja) 2005-12-19 2007-03-28 オリンパス株式会社 Ｄｎａ増幅装置
JP2007178328A (ja) 2005-12-28 2007-07-12 Shimadzu Corp 反応容器キット及び反応容器処理装置
US20070154895A1 (en) 2005-12-30 2007-07-05 Caliper Life Sciences, Inc. Multi-assay microfluidic chips
EP1966585A2 (en) 2005-12-30 2008-09-10 Caliper Life Sciences, Inc. Integrated dissolution processing and sample transfer system
SG134186A1 (en) 2006-01-12 2007-08-29 Nanyang Polytechnic Smart nano-integrated system assembly
WO2007091530A1 (ja) 2006-02-07 2007-08-16 The Furukawa Electric Co., Ltd. 光検出装置及び測定対象読取装置
US8124033B2 (en) 2006-02-17 2012-02-28 Agency, Science, Technology and Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same
USD538436S1 (en) 2006-03-06 2007-03-13 Steris Inc. Reprocessor for decontaminating medical, dental and veterinary instruments and articles
JP5415253B2 (ja) 2006-03-24 2014-02-12 ハンディラブ・インコーポレーテッド 微小流体サンプルを処理するための一体化システム及びその使用方法
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
USD569526S1 (en) 2006-03-27 2008-05-20 Handylab, Inc. Molecular diagnostic instrument
USD559995S1 (en) 2006-03-27 2008-01-15 Handylab, Inc. Controller cartridge for a diagnostic instrument
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
US8021531B2 (en) 2006-04-14 2011-09-20 Caliper Life Sciences, Inc. Method for modifying the concentration of reactants in a microfluidic device
USD554069S1 (en) 2006-05-03 2007-10-30 Data I/O Corporation Processing apparatus
USD554070S1 (en) 2006-05-03 2007-10-30 Data I/O Corporation Processing apparatus
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
CN101522909A (zh) 2006-05-17 2009-09-02 加利福尼亚技术学院 热循环系统
JP2009540290A (ja) 2006-06-08 2009-11-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Ｄｎａ検出用ミクロ電子工学センサ装置
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US9278321B2 (en) 2006-09-06 2016-03-08 Canon U.S. Life Sciences, Inc. Chip and cartridge design configuration for performing micro-fluidic assays
US8246919B2 (en) 2006-09-21 2012-08-21 Abbott Laboratories Specimen sample rack
US20080095673A1 (en) 2006-10-20 2008-04-24 Lin Xu Microplate with fewer peripheral artifacts
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
KR101422467B1 (ko) 2007-02-08 2014-07-24 삼성전자주식회사 미세유체 칩 내의 형광을 검출하기 위한 시스템 및 형광검출 방법
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
JP2008267950A (ja) 2007-04-19 2008-11-06 Enplas Corp 流体取扱装置
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
GB0719193D0 (en) 2007-10-02 2007-11-07 Advanced Biotech Ltd A Vessel
USD632799S1 (en) 2008-05-15 2011-02-15 The Automation Partnership Cell dispenser
AU2009257644B2 (en) 2008-06-09 2015-05-07 Qiagen Gaithersburg, Inc. Magnetic microplate assembly
USD596312S1 (en) 2008-06-13 2009-07-14 Csp Technologies, Inc. Vial rack
USD595423S1 (en) 2008-06-30 2009-06-30 Ge Healthcare Bio-Sciences Ab Magnetic rack
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD598566S1 (en) 2008-08-12 2009-08-18 Diagenode Societe Anonyme Medical instrument for laboratory use
CN102203605B (zh) 2008-08-27 2014-07-23 生命技术公司 处理生物样品的设备和方法
WO2010118541A1 (en) 2009-04-15 2010-10-21 Biocartis Sa OPTICAL DETECTION SYSTEM FOR MONITORING rtPCR REACTION
USD599234S1 (en) 2009-04-28 2009-09-01 Shiseido Co., Ltd. Auto-sampler for chromatograph
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
USD638953S1 (en) 2009-05-12 2011-05-31 Invitrogen Dynal As Laboratory apparatus
WO2010130310A1 (en) 2009-05-15 2010-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pipette head with filter and flushing means
EP2263802A1 (en) 2009-05-25 2010-12-22 F. Hoffmann-La Roche AG System and method for dispensing fluids
WO2010140680A1 (ja) * 2009-06-04 2010-12-09 ユニバーサル・バイオ・リサーチ株式会社 検体検査装置およびその方法
USD628305S1 (en) 2009-07-14 2010-11-30 Medical Research Council Sitting-drop microwell plate for crystalization
US8282895B2 (en) 2009-09-15 2012-10-09 Qiagen Gaithersburg, Inc. Reagent cabinet system
US20110097493A1 (en) 2009-10-27 2011-04-28 Kerr Roger S Fluid distribution manifold including non-parallel non-perpendicular slots
JP2013520643A (ja) 2010-02-22 2013-06-06 フォーティテュード リミテッド マルチウェル・ストリップ
ES2583643T3 (es) 2010-04-01 2016-09-21 F. Hoffmann-La Roche Ag Método implementado por ordenador para operar una celda de trabajo para muestras automatizada
US20110300033A1 (en) * 2010-06-07 2011-12-08 Chemence Medical, Inc. Pipette Holder and Applicator Apparatus
CN103551212B (zh) 2010-07-23 2016-01-20 贝克曼考尔特公司 试剂盒
US20130183769A1 (en) 2010-09-17 2013-07-18 Universal Bio Research Co., Ltd. Cartridge and automatic analysis device
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR102121853B1 (ko) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 일체화된 시약 스트립
JP6420148B2 (ja) 2011-10-14 2018-11-07 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 矩形波サーマルサイクリング
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
USD686749S1 (en) 2012-04-20 2013-07-23 Stratec Biomedical Ag Rack for holding sheaths
USD702854S1 (en) 2012-05-18 2014-04-15 Yoko Nakahana Micro tube array container
USD687567S1 (en) 2012-10-22 2013-08-06 Qiagen Gaithersburg, Inc. Tube strip for automated processing systems
USD710024S1 (en) 2013-03-14 2014-07-29 Bio-Rad Laboratories, Inc. Microplate
EP4129482A1 (en) 2013-03-16 2023-02-08 Leslie Don ROBERTS Self-contained modular analytical cartridge and programmable reagent delivery system
CH709054A1 (de) 2013-12-20 2015-06-30 Tecan Trading Ag Abstandhalter für übereinandergestapelte Pipettenspitzen-Träger.
USD729404S1 (en) 2014-06-02 2015-05-12 Seahorse Bioscience Carrier
USD787008S1 (en) 2015-06-29 2017-05-16 David Hale Shooting target

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143250A (en) * 1995-07-31 2000-11-07 Precision System Science Co., Ltd. Multi-vessel container for testing fluids
US6238626B1 (en) * 1998-04-13 2001-05-29 Matsushita Electric Industrial Co., Ltd. Automatic distribution apparatus and method of distribution
WO2004055522A1 (en) * 2002-12-13 2004-07-01 Innotrac Diagnostics Oy Analyzer and analysing method and a fluid cartridge
CN101802164A (zh) * 2007-07-13 2010-08-11 汉迪实验室公司 用于在多个生物样品上进行核酸提取和诊断测试的集成装置
CN101918581A (zh) * 2007-10-10 2010-12-15 普凯尔德诊断技术有限公司 用于鉴定尿中细菌的系统

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