CN103908357A - Artificial skeletal structure - Google Patents
Artificial skeletal structure Download PDFInfo
- Publication number
- CN103908357A CN103908357A CN201410139523.4A CN201410139523A CN103908357A CN 103908357 A CN103908357 A CN 103908357A CN 201410139523 A CN201410139523 A CN 201410139523A CN 103908357 A CN103908357 A CN 103908357A
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- China
- Prior art keywords
- artificial skelecton
- artificial
- skelecton
- skeleton
- along
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
The invention provides an artificial skeletal structure which can lower elasticity modulus of an artificial skeleton made of biological titanium alloy to enable the artificial skeleton to be more similar to a natural skeleton. The artificial skeletal structure comprises an artificial skeleton body and is characterized in that the artificial skeleton body is internally provided with a plurality of cavities which penetrate through the artificial skeleton in the length direction, and accordingly a hollow structure in the artificial skeleton body is formed.
Description
Technical field
The present invention relates to technical field of bioengineering, be specially a kind of artificial skelecton structure.
Background technology
In metallic biomaterial, the cobalt chromium of the rustless steel of the first generation and the second filial generation or vitallium, because its elastic modelling quantity is high more than natural skeleton, are unfavorable for reproducing and healing of natural skeleton tissue after implantation, and therefore clinical practice is gradually reducing.Biological titanium alloy has obvious superiority compared with the first and second substituting metal biomaterials, for example, ideal bio-compatibility, outstanding corrosion resistance, high fatigue strength, low elastic modulus, therefore titanium alloy is that long-acting or permanent human body is implanted optimal metallic biomaterial.
Although the elastic modelling quantity of biological titanium alloy is far below the first and second substituting metal biomaterials, higher (biological titanium alloy: 50～120GPa still compared with natural skeleton; Bone: 20～30GPa), can make biological titanium alloy and natural skeleton more approaching if therefore can further reduce the elastic modelling quantity of biological titanium alloy, thereby meet the application of artificial skelecton in biological engineering.At present, there is the artificial skelecton of manufacturing by adopting the foam metals such as titanium foam or titanium foam alloy, because elastic modelling quantity and the natural skeleton of foam metal material are more approaching, especially the foam hole existing in foam metal also has great significance to the healing that promotes tissue, but the foam hole in its artificial skelecton of the artificial skelecton of being made up of foam metal material mostly is monomer closing structure, between each hole, cannot connect, thereby the body fluid after causing this artificial skelecton to implant in skeleton or bone marrow can not permeate and flow, thereby be unfavorable for that artificial skelecton is combined with the growth of natural skeleton, also be unfavorable for the recovery of skeletal function, in addition, adopt at present foam metal to manufacture the complex process of artificial skelecton, the processing technique complexity of foam metal on the one hand, mostly foam metal is to be processed into artificial skelecton by the form of hot investment casting on the other hand, and usually cause manufacturing and designing in advance different bone shape molds because individual variation, implantation position are different in actual applications, thereby cause the manufacturing cost of artificial skelecton high, the manufacturing cycle is long.
Summary of the invention
For the problems referred to above, the invention provides a kind of artificial skelecton structure, its can solve because of the artificial skelecton inner pore of existing foam metal material manufacture cannot connect the artificial skelecton causing and implant after body fluid or bone marrow can not permeate and mobile problem, itself and natural skeleton are more approaching, are conducive to artificial skelecton and are combined with the growth of natural skeleton.
Its technical scheme is such, and it comprises artificial skelecton body, it is characterized in that: described artificial skelecton body interior has some cavitys that connect along its length described artificial skelecton body, thereby forms the intrinsic hollow structure of described artificial skelecton.
It is further characterized in that:
Described some cavitys are radially uniformly distributed along artificial skelecton body, and described cavity is 10%～90% along artificial skelecton body distribution density radially;
Described some cavitys along artificial skelecton body radially from inside to outside by by dredging to close transition profile gradually.
It is further characterised in that:
Described cavity is skeleton hole, and described some skeleton holes all connect described artificial skelecton body along bone length direction and form hollow structure;
Described some skeleton holes are along described artificial skelecton body length direction layered distribution;
The complete stacked perforation of described skeleton hole of described adjacent layer, the hollow structure of formation tubular;
The local intersecting of described skeleton hole of described adjacent layer, the webbed hollow structure of shape.
Its further feature be also:
The intrinsic hollow structure of described artificial skelecton is made up of the three-dimensional rack structure of some inside hollow outs that adjoin each other, thereby described some three-dimensional rack structures adjoin each other and the cavity of adjacent described three-dimensional rack inside configuration hollow out interpenetrated form the cavity that connects described artificial skelecton body.
Described cavity is built-in with medicine.
The beneficial effect of the artificial skeletal structure of the present invention is: it has some cavitys that connect along its length described artificial skelecton in artificial skelecton body, thereby form the intrinsic hollow structure of artificial skelecton, make artificial skelecton structure and natural skeleton structure more approaching, and the hollow structure of artificial skelecton is conducive to body fluid or the infiltration of bone marrow in artificial skelecton and flows, and then be conducive to after artificial skelecton is implanted be combined with the growth of natural skeleton, be conducive to afterwards the recovery of skeletal function; In addition, the radial distribution of the some cavitys in artificial skelecton can be to be uniformly distributed, also can be direction from inside to outside by by dredging to close transition profile gradually, thereby guarantee that artificial skeletal structure can meet the requirement of different natural skeleton density, make artificial skelecton structure and the natural skeleton structure of combination to be grown more be tending towards approaching, be more conducive to afterwards the recovery of skeletal function; In addition, the cavity in artificial skelecton, can directly be made up of skeleton hole, also can be made up of the three-dimensional rack structure of inner hollow out, thereby meet the requirement of different artificial skelecton structures; Skeleton hole is built-in with medicine in addition, and after artificial skelecton implants, medicine can be along with the infiltration of body fluid in skeleton or bone marrow and the mobile effect of playing local sustained release administration.
Accompanying drawing explanation
Fig. 1 is the sectional schematic diagram of the artificial skeletal structure of the present invention;
Fig. 2 is that in the present invention, skeleton hole is regular hexagon and radially equally distributed tubular hollow structure schematic diagram;
Fig. 3 is that in the present invention, skeleton hole is regular hexagon and radially equally distributed netted hollow structure schematic diagram;
Fig. 4 is that in the present invention, skeleton hole is the schematic perspective view of regular hexagon and radially equally distributed netted hollow structure;
Fig. 5 is that in the present invention, skeleton hole is equilateral triangle and radially equally distributed tubular hollow structure schematic diagram;
Fig. 6 is that in the present invention, skeleton hole is equilateral triangle and radially equally distributed netted hollow structure schematic diagram;
Fig. 7 for skeleton hole in the present invention be the schematic perspective view of equilateral triangle and radially equally distributed netted hollow structure;
Fig. 8 is the three-dimensional rack structural cavities schematic diagram being formed by some regular octahedron three-dimensional rack structures adjacency in the present invention;
Fig. 9 is the three-dimensional rack structural cavities schematic diagram being formed by some granatohedron three-dimensional rack structures adjacency in the present invention;
Figure 10 is single granatohedron three-dimensional rack structural representation in Fig. 9;
Figure 11 be in the present invention some skeleton holes 2 on the sagittal plane of artificial skelecton body from inside to outside by by close to dredging the schematic diagram of transition profile gradually.
The specific embodiment
The artificial skeletal structure of the present invention comprises artificial skelecton body 1, and artificial skelecton body 1 inside has some cavitys that connect along its length artificial skelecton, thereby forms the intrinsic hollow structure of described artificial skelecton.
See Fig. 1, some cavitys are made up of some skeleton holes 2, and some skeleton holes all connect described artificial skelecton body along bone length direction and form hollow structure; Some skeleton holes 2 are uniformly distributed on the sagittal plane of artificial skelecton body, and the density of skeleton hole 2 is 10%～90%; Some skeleton holes 2 also can, from inside to outside by by dredging to close transition profile gradually, be shown in Figure 11 on the sagittal plane of artificial skelecton body; Skeleton hole 2 is built-in with medicine; Some skeleton holes are along artificial skelecton body length direction layered distribution, wherein when the complete stacked perforation of skeleton hole of adjacent layer, form the hollow structure of tubular, see Fig. 2 and Fig. 4; When the local intersecting of skeleton hole of adjacent layer, the webbed hollow structure of shape, is shown in Fig. 3, Fig. 4, Fig. 6 and Fig. 7;
The intrinsic hollow structure of artificial skelecton also can be made up of the three-dimensional rack structure 3 of some inside hollow outs that adjoin each other, thereby the three-dimensional rack structure of some inner hollow outs adjoins each other and the cavity of adjacent three-dimensional rack structure is interpenetrated form the cavity that connects described artificial skelecton body, and the three-dimensional rack structure of inner hollow out can adopt regular octahedron supporting structure (see figure 8) or granatohedron supporting structure (seeing Fig. 9, Figure 10).
The method that artificial skelecton structure of the present invention is printed by 3D can make, and it does not need to manufacture and design in advance bone shape mold to adopt 3D to print manufacture artificial skelecton, thereby manufactures fast, and low cost of manufacture, is applicable to the principle customizing in real time in artificial skelecton application process.
Claims (9)
1. an artificial skelecton structure, it comprises artificial skelecton body, it is characterized in that: described artificial skelecton body interior has some cavitys that connect along its length described artificial skelecton body, thereby forms the intrinsic hollow structure of described artificial skelecton.
2. a kind of artificial skelecton structure according to claim 1, is characterized in that: described some cavitys are radially uniformly distributed along artificial skelecton body, described cavity is 10%～90% along the density of described artificial skelecton body distribution radially.
3. a kind of artificial skelecton structure according to claim 1, is characterized in that: described some cavitys along described artificial skelecton body radially from inside to outside by by dredging to close transition profile gradually.
4. according to arbitrary described a kind of artificial skelecton structure in claim 1,2 or 3, it is characterized in that: described cavity is skeleton hole, described some skeleton holes all connect described artificial skelecton body along bone length direction and form hollow structure.
5. according to arbitrary described a kind of artificial skelecton structure in claim 4, it is characterized in that: described some skeleton holes are along described artificial skelecton body length direction layered distribution.
6. according to arbitrary described a kind of artificial skelecton structure in claim 5, it is characterized in that: the complete stacked perforation of described skeleton hole of described adjacent layer, the hollow structure of formation tubular.
7. according to arbitrary described a kind of artificial skelecton structure in claim 5, it is characterized in that: the local intersecting of described skeleton hole of described adjacent layer, the webbed hollow structure of shape.
8. according to arbitrary described a kind of artificial skelecton structure in claim 1,2 or 3, it is characterized in that: the intrinsic hollow structure of described artificial skelecton is made up of the three-dimensional rack structure of some inside hollow outs that adjoin each other, thereby described some three-dimensional rack structures adjoin each other and the cavity of adjacent described three-dimensional rack structure are interpenetrated form the cavity that connects described artificial skelecton body.
9. a kind of artificial skelecton structure according to claim 1, is characterized in that: described cavity is built-in with medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410139523.4A CN103908357B (en) | 2014-04-09 | 2014-04-09 | Artificial skeletal structure |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410139523.4A CN103908357B (en) | 2014-04-09 | 2014-04-09 | Artificial skeletal structure |
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| CN103908357A true CN103908357A (en) | 2014-07-09 |
| CN103908357B CN103908357B (en) | 2017-01-11 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104207867A (en) * | 2014-08-13 | 2014-12-17 | 中国科学院福建物质结构研究所 | Low-modulus medical implant porous scaffold structure |
| CN105287054A (en) * | 2015-11-06 | 2016-02-03 | 郝明仲 | Honeycomb-like skeleton prosthesis stereo structure and application thereof |
| CN108404222A (en) * | 2018-05-25 | 2018-08-17 | 湖南早晨纳米机器人有限公司 | A kind of POROUS TITANIUM based nano composite material for hard tissue material and preparation method thereof, application |
| CN109172049A (en) * | 2018-09-13 | 2019-01-11 | 浙江工业大学 | A kind of porous network structure orthopaedics based on the connection of laminated sheet bar repairs the designing and manufacturing method and implant of implant |
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| US6206924B1 (en) * | 1999-10-20 | 2001-03-27 | Interpore Cross Internat | Three-dimensional geometric bio-compatible porous engineered structure for use as a bone mass replacement or fusion augmentation device |
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| CN201139625Y (en) * | 2007-12-29 | 2008-10-29 | 北京吉马飞科技发展有限公司 | Tridimensional gridding shaped bone filler |
| US20110014081A1 (en) * | 2004-12-30 | 2011-01-20 | Howmedica Osteonics Corp. | Laser-produced porous structure |
| US20110196495A1 (en) * | 2008-12-18 | 2011-08-11 | 4-Web Spine, Inc. | Implant system and method |
| CN102548509A (en) * | 2009-08-19 | 2012-07-04 | 史密夫和内修有限公司 | Porous implant structures |
| CN103445883A (en) * | 2012-06-04 | 2013-12-18 | 合硕生技股份有限公司 | Medical hollow-out rack implant |
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Patent Citations (7)
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| US6206924B1 (en) * | 1999-10-20 | 2001-03-27 | Interpore Cross Internat | Three-dimensional geometric bio-compatible porous engineered structure for use as a bone mass replacement or fusion augmentation device |
| US20110014081A1 (en) * | 2004-12-30 | 2011-01-20 | Howmedica Osteonics Corp. | Laser-produced porous structure |
| CN101141987A (en) * | 2005-02-23 | 2008-03-12 | Hi-Lex株式会社 | Medical material, artificial tooth root and method of producing material for clinical use |
| CN201139625Y (en) * | 2007-12-29 | 2008-10-29 | 北京吉马飞科技发展有限公司 | Tridimensional gridding shaped bone filler |
| US20110196495A1 (en) * | 2008-12-18 | 2011-08-11 | 4-Web Spine, Inc. | Implant system and method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104207867A (en) * | 2014-08-13 | 2014-12-17 | 中国科学院福建物质结构研究所 | Low-modulus medical implant porous scaffold structure |
| CN105287054A (en) * | 2015-11-06 | 2016-02-03 | 郝明仲 | Honeycomb-like skeleton prosthesis stereo structure and application thereof |
| CN105287054B (en) * | 2015-11-06 | 2017-07-07 | 郝明仲 | The cellular bone prosthesis stereochemical structure of one species and its application |
| CN108404222A (en) * | 2018-05-25 | 2018-08-17 | 湖南早晨纳米机器人有限公司 | A kind of POROUS TITANIUM based nano composite material for hard tissue material and preparation method thereof, application |
| CN109172049A (en) * | 2018-09-13 | 2019-01-11 | 浙江工业大学 | A kind of porous network structure orthopaedics based on the connection of laminated sheet bar repairs the designing and manufacturing method and implant of implant |
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| Publication number | Publication date |
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| CN103908357B (en) | 2017-01-11 |
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