CN103884751A - Continuous production method of serial biosensor for blood quick detection - Google Patents
Continuous production method of serial biosensor for blood quick detection Download PDFInfo
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- CN103884751A CN103884751A CN201410158092.6A CN201410158092A CN103884751A CN 103884751 A CN103884751 A CN 103884751A CN 201410158092 A CN201410158092 A CN 201410158092A CN 103884751 A CN103884751 A CN 103884751A
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Abstract
The invention provides a continuous production method of a serial biosensor for blood quick detection, which is characterized by comprising the following steps: 1) electrode printing; 2) siphon film packaging; and 3) sensor cutting, detection and packaging. A roll-to-roll continuous production mode is adopted in each step, thereby overcoming the defects of low efficiency and uncontrollable quality in the traditional uniwafer printing operation, and implementing continuous automatic high-efficiency production of the biosensor. Compared with the traditional manual uniwafer operation production mode, the technique provided by the invention can greatly reduce the quantity of operators and lower the labor cost; the technique greatly enhances the automation level, lowers the labor intensity of the operators, and improves the working environment; the technique reduces the artificial errors on the product by the operators in various steps, and enhances the uniformity and quality of product; and the roll-to-roll continuous production mode greatly enhances the production efficiency and greatly lowers the production cost.
Description
Technical field
The present invention relates to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor.
Background technology
Along with the development of industrialization society and improving constantly of people's biochemistry level, people's living environment, working method and dietary structure all have a very large change.Hypertension, the incidence of disease of high fat of blood and diabetes etc. " metabolic syndrome " presents and increases year by year and towards the development trend becoming younger.Therefore, to the omen in advance of this type of disease, as the variation of the biochemical indicators such as blood sugar, urea, cholesterol, lactic acid, carry out effective, easy, fast and accurately measure, more cause the concern of medical profession.
Portable quick biochemistry detection instrument is because it is easy to carry, simple to operate, blood using amount is few, go out fast the more prevalent use of the outstanding advantages such as result, this type of detecting instrument mostly adopts dry chemical biology sensor as front end detecting head, combines just can carry out field quick detection with the portable apparatus of rear end.On market, the product of comparative maturity has blood glucose meter, lactic acid and dry type whole blood biochemistry analyzing instrument etc. and corresponding all kinds of biochemical indicator chemical biosensor (as blood sugar test paper bar).
At present, on market, existing multiple brand blood sugar examination bar, very similar in structure, production technology is the traditional silk-screened machine monolithic printing operations that adopt also more, not only production efficiency is low, cannot meet the growing market demand, and the quality of production because of human factor be difficult to control.Therefore, if can develop a kind of method of producing for the serialization of blood fast detecting series of biologic sensor, adopt the mode of production of advanced serialization, there are very important using value and market outlook.
Summary of the invention
The invention provides a kind of method of producing for the serialization of blood fast detecting series of biologic sensor, be divided into three road flowing water operations: 1) electrode printing, 2) siphon thin-film package, 3) sensor cutting, detection, packaging, every procedure has all adopted the mode of production of serialization volume to volume, mainly comprises following characteristics step:
1. web-like flexible parent metal is packed into volume to volume printing machine blowing end, base material, successively by after printing machine and dryer, is fixed on volume to volume printing machine rewinding end, together with being attached on web-like double faced adhesive tape;
2. pack the silk screen of predetermined pattern into printing machine, printing slurry is put into slurry tank, and at substrate surface printed electrode, the base material after printing is through oven for drying, pastes, rolling with double faced adhesive tape;
3. base material last process being made unreels, and collects the protection sheet of double faced adhesive tape, encapsulation siphon film, rolling;
4. base material last process being made unreels, and base material is made monolithic test strips through cutting, detection, packaging process successively.
The web-like flexible parent metal of step described in is 1. PET, PS, the macromolecular materials such as PC.
The printing of step described in 1. and dryer can increase in pairs or reduce according to process requirements.
The volume to volume printing machine of step described in 1., adopts the mode of production of serialization, can realize the feeding of volume to volume Automatic continuous, printing, rewinding, and process speed is 0.1-1m/s.
The printing of the electrode of step described in 1., can adopt continous way roll printing or plane screen printer for printing.
The baking oven of step described in 2., selects according to the material of base material, and temperature range is 50-100 DEG C, adopts continuous type drying, and drying rate is consistent with print speed printing speed.
Double faced adhesive tape and the base material electrode of step described in 2. forms micro-reaction zone, fixed electrode reaction area, and the thickness of double faced adhesive tape has determined the height of micro-reaction zone.
The siphon film of step described in 3. and double faced adhesive tape and basal electrode form semiclosed reaction microchamber chamber, and an end opening, is reactant liquor entrance.
The invention provides a kind of method of producing for the serialization of blood fast detecting series of biologic sensor, it is characterized in that, the serialization of blood fast detecting series of biologic sensor is produced and is divided into three road flowing water operations: 1) electrode printing, 2) siphon thin-film package, 3) sensor cutting, detection, packaging.Because every procedure has all adopted the mode of production of serialization volume to volume, overcome that conventional one-piece printing operation efficiency is low, the shortcoming of difficult quality control, realize serialization, robotization, the high efficiency production of biology sensor.Compared with the mode of production of this technique and traditional artificial one-step operation, can reduce greatly operating personnel's quantity, reduce cost of labor; Automatization level significantly improves, and reduces operating personnel's labour intensity, improves work situation; Reduce the personal error that operating personnel cause product in each operation, improved consistance and the product quality of product; The serialization of volume to volume formula is produced and has greatly been improved production efficiency, significantly reduces production costs.
Brief description of the drawings
Fig. 1 is the volume to volume printing schematic diagram that the present invention produces for the serialization of blood fast detecting series of biologic sensor.Wherein, 1 discharging device; 2 Destaticizing devices; 3 roll printings or accurate coating; 4 drying boxes; 5 material collecting devices; 6 paste two-faced adhesive tape apparatus.
Fig. 2 is the siphon thin-film package schematic diagram that the present invention produces for the serialization of blood fast detecting series of biologic sensor.Wherein, 1 discharging device; 2 material collecting devices; 3 receive double faced adhesive tape protection sheet device; 4 paste siphon membrane unit.
Fig. 3 is cutting, detection, the packaging process schematic diagram that the present invention produces for the serialization of blood fast detecting series of biologic sensor.Wherein, 1 discharging device; 2 transfer rate snubber assemblys; 3 optical precision alignment device; 4 online macroscopic examination devices; 5 coiled material Scissoring devices; 6 specification product part flow arrangements; Wrapping paper on 7; 8 times wrapping papers; 9 sheet material Scissoring devices; 10 product cartonnings.
Specific embodiments
The following examples are further described the present invention in connection with Figure of description.
Embodiment is a kind of to be produced for the serialization of blood fast detecting series of biologic sensor, is divided into three road flowing water operations.1) PET coiled material is packed into volume to volume printing machine blowing end, base material by after the first printing machine and dryer and the second printing machine and dryer, is fixed on volume to volume printing machine rewinding end, together with being attached on web-like double faced adhesive tape successively; The silk screen of predetermined pattern is arranged on to volume to volume printing machine, and printing slurry is put into slurry tank, and setting print speed printing speed is 0.5m/s, and oven temperature is 60 DEG C.Print conductive substrates at the first printing machine place, print enzyme working electrode at the second printing machine place, base material, after baking oven is dried successively, is pasted with double faced adhesive tape, rolling.2) base material last process being made unreels, and speed is 0.5m/s, collects the protection sheet of double faced adhesive tape, encapsulates rolling after siphon film simultaneously.3) base material finally second operation work being made unreels, and base material is made monolithic test strips through cutting, detection, packaging process successively.
Claims (10)
1. a method of producing for the serialization of blood fast detecting series of biologic sensor, be divided into three road flowing water operations: 1) electrode printing, 2) siphon thin-film package, 3) sensor cutting, detection, packaging, every procedure has all adopted the mode of production of serialization volume to volume, it is characterized in that comprising following characteristics step:
1. web-like flexible parent metal is packed into volume to volume printing machine blowing end, base material, successively by after printing machine and dryer, is fixed on volume to volume printing machine rewinding end, together with being attached on web-like double faced adhesive tape;
2. pack the silk screen of predetermined pattern into printing machine, printing slurry is put into slurry tank, and at substrate surface printed electrode, the base material after printing is through oven for drying, pastes, rolling with double faced adhesive tape;
3. base material last process being made unreels, and collects the protection sheet of double faced adhesive tape, encapsulation siphon film, rolling;
4. base material last process being made unreels, and base material is made monolithic test strips through cutting, detection, packaging process successively.
2. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the web-like flexible parent metal of step described in is 1. PET, PS, the macromolecular materials such as PC.
3. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the printing of step described in 1. and dryer can increase in pairs or reduce according to process requirements.
4. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the volume to volume printing machine of step described in 1., adopt the mode of production of serialization, can realize the feeding of volume to volume Automatic continuous, printing, rewinding, process speed is 0.1-1m/s.
5. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the printing of the electrode of step described in 1., can adopt continous way roll printing or plane screen printer for printing.
6. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that the baking oven of step described in 2., select according to the material of base material, temperature range is 50-100 DEG C, adopts continuous type drying, and drying rate is consistent with print speed printing speed.
7. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, double faced adhesive tape and the base material electrode of step described in 2. forms micro-reaction zone, fixed electrode reaction area, and the thickness of double faced adhesive tape has determined the height of micro-reaction zone.
8. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the siphon film of step described in 3. and double faced adhesive tape and basal electrode form semiclosed reaction microchamber chamber, and an end opening, is reactant liquor entrance.
9. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, step 4. described adhesive film material, wrapping paper adopts coiled material material loading, realizes automatic continuous production.
10. according to a kind of method of producing for the serialization of blood fast detecting series of biologic sensor claimed in claim 1, it is characterized in that, the serialization of blood fast detecting series of biologic sensor is produced and is divided into three road flowing water operations: 1) electrode printing, 2) siphon thin-film package, 3) sensor cutting, detection, packaging.Because every procedure has all adopted the mode of production of serialization volume to volume.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410158092.6A CN103884751A (en) | 2014-04-18 | 2014-04-18 | Continuous production method of serial biosensor for blood quick detection |
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| CN201410158092.6A CN103884751A (en) | 2014-04-18 | 2014-04-18 | Continuous production method of serial biosensor for blood quick detection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731622A (en) * | 2018-12-30 | 2019-05-10 | 深圳博华仕科技有限公司 | A kind of electrode print of micro-fluidic chip makes device and print makes method |
| CN110665770A (en) * | 2019-11-12 | 2020-01-10 | 徐詹程 | Method for manufacturing multilayer film dry chemical reagent sheet |
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| WO2005010518A1 (en) * | 2003-07-23 | 2005-02-03 | Dexcom, Inc. | Rolled electrode array and its method for manufacture |
| CN1849852A (en) * | 2003-09-09 | 2006-10-18 | At&S奥地利科技及系统技术股份公司 | Thin-film assembly and method for producing said assembly |
| WO2009103339A1 (en) * | 2008-02-21 | 2009-08-27 | Valtion Teknillinen Tutkimuskeskus | Biosensor and a related manufacturing method |
| CN102662522A (en) * | 2012-04-16 | 2012-09-12 | 姜洪波 | Method for manufacturing flexible touch screen and equipment for manufacturing touch electrode coil |
| CN202592917U (en) * | 2012-04-16 | 2012-12-12 | 姜洪波 | Roll-to-roll positioning and combining device |
| CN202758329U (en) * | 2012-04-16 | 2013-02-27 | 姜洪波 | Equipment for preparing touch electrode roll materials for flexible touch screens |
| CN202770473U (en) * | 2012-07-27 | 2013-03-06 | 江苏物联网研究发展中心 | Flexible multi-parameter sensor |
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| CN1429062A (en) * | 2001-12-28 | 2003-07-09 | 精工爱普生株式会社 | Method and device for mfg. printed circuit board |
| WO2005010518A1 (en) * | 2003-07-23 | 2005-02-03 | Dexcom, Inc. | Rolled electrode array and its method for manufacture |
| CN1849852A (en) * | 2003-09-09 | 2006-10-18 | At&S奥地利科技及系统技术股份公司 | Thin-film assembly and method for producing said assembly |
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| CN202758329U (en) * | 2012-04-16 | 2013-02-27 | 姜洪波 | Equipment for preparing touch electrode roll materials for flexible touch screens |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731622A (en) * | 2018-12-30 | 2019-05-10 | 深圳博华仕科技有限公司 | A kind of electrode print of micro-fluidic chip makes device and print makes method |
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| CN110665770A (en) * | 2019-11-12 | 2020-01-10 | 徐詹程 | Method for manufacturing multilayer film dry chemical reagent sheet |
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Application publication date: 20140625 |