CN103800023B - A kind of two flatbed imaging device based on continuous crystal - Google Patents
A kind of two flatbed imaging device based on continuous crystal Download PDFInfo
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- CN103800023B CN103800023B CN201410056890.8A CN201410056890A CN103800023B CN 103800023 B CN103800023 B CN 103800023B CN 201410056890 A CN201410056890 A CN 201410056890A CN 103800023 B CN103800023 B CN 103800023B
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- continuous crystal
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Abstract
The invention discloses a kind of two flatbed imaging device based on continuous crystal, comprise two detecting modules, described detecting module comprises continuous crystal, photoelectric conversion part and array read-out electronics system, described photoelectric conversion part is adjacent to described continuous crystal, and described array read-out electronics system is connected with described photoelectric conversion part.The present invention adopts two slab construction, and detecting module of the present invention adopts continuous crystal, effectively solves effect of depth, and there is not detection dead band, is conducive to improving detection efficient and detectivity, thus improves precision and the reliability of imaging.
Description
Technical field
The present invention relates to molecular imaging field, be specifically related to two flatbed imaging device.
Background technology
Nucleus medical image technology can reflect the metabolic characteristics of people's in-vivo tissue organ by the mode of image, by early diagnosis can be carried out to a series of major diseases such as tumor, cardiovascular disease, nervous system disease to the analysis of these metabolic characteristicss, be the pith of medical image, there are bright prospects.
In tumor disease diagnosis, in diagnosis, play important function based on X-ray or ultrasonic Diagnostic technique and procedure, significantly improved Diagnosis and Treat effect.But the diagnostic imaging of these methods all structure based pathological changes, in canceration type and by stages, qualitative etc. in effect poor, be also difficult to meet early diagnosis requirement to picture quality during soft-tissue imaging.MRI soft-tissue imaging can obtain good contrast effect, but imaging specificity is lower, easily cause fail to pinpoint a disease in diagnosis, mistaken diagnosis.Biomedical research shows, before recurring structure pathological changes, it functionally there occurs pathological changes to human organ, molecular image diagnostic device based on positron emission tomography can carry out imaging to metabolic function change, therefore can be more early stage diagnose tumor disease, improves Diagnosis and Treat effect further.
At present for the PET(functional metabolism video picture of tumor disease diagnosis) imaging device mainly comprises polygonized structure and two slab construction.Polygonized structure detection angle is more, does not need to carry out motor control to detector, but application scenarios is more fixing, underaction, and cost is also relatively high.Two slab construction can control the distance between two flat boards, and can rotating acquisition different angles, and imaging mode is flexible and changeable, and application scenarios is also more extensive.But relatively large in detector area, when distance is relatively near, therefore have obvious effect of depth (DOI), effect of depth makes the line of response (LOR) that meets recorded depart from positron-electron annihilation position, finally causes reconstructed image quality to decline.
Texture form for the scintillator detector of PET imaging device comprises crystal strip array and continuous crystal.Crystal strip array can obtain the plan-position of incident γ photon eaily, and reading circuit is relative with location algorithm simple, but cannot provide the depth information of incident γ photon, and spatial resolution is also limited to the size of crystal bar, there is detection dead band.
Summary of the invention
For problems of the prior art, object of the present invention is for providing a kind of high-resolution imaging device.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of two flatbed imaging device based on continuous crystal, comprise two detecting modules, described detecting module comprises continuous crystal, photoelectric conversion part and array read-out electronics system, described photoelectric conversion part is adjacent to described continuous crystal, and described array read-out electronics system is connected with described photoelectric conversion part.
Further, described continuous crystal four sides and upper surface scribble light absorbent.
Further, described continuous crystal is connected by photoconduction or optic grease direct-coupling with described photoelectric conversion part.
Further, described array read-out electronics system is that multichannel reads.
Further, also comprise and meet plate and host computer data handling system, meet plate described in described two detecting modules all pass through and be connected to described host computer data handling system, the described plate that meets judges whether two γ photon signals of detecting module collection described in two take place at the same instant, and then two signals are sent to described host computer data handling system in this way.
Further, described host computer data handling system or described array read-out electronics system comprise position fitting unit, described photoelectric conversion part comprises multiple probe units of array arrangement, described position fitting unit is according to the detected intensity distribution I (m of described each probe unit, n), matching draws active position s (x, the y of the γ photon that extraneous radioactive source is injected and described continuous crystal, z), wherein m and n is the Position Number of probe unit.
Further, described position fitting unit adopts solid angle model, and in described photoelectric conversion part, (m, n) individual probe unit is to point source position s(x, y, z) open solid angle and be specially:
Wherein,
be (m, n) individual probe unit to point source position s(x, y, z) open solid angle;
W is the width of each probe unit;
H is the height of each probe unit;
X, y, z is the active position of described γ photon and continuous crystal.
Further, adopt the active position of solid angle model to γ photon and continuous crystal to carry out matching, and introduce normalization factor A in model of fit, and
Compared with prior art, the present invention adopts two slab construction, and detecting module of the present invention adopts continuous crystal in the present invention, effectively solve effect of depth, and there is not detection dead band, be conducive to improving detection efficient and detectivity, thus improve precision and the reliability of imaging.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the present invention is described in further detail:
Fig. 1 is the structural representation of imaging device of the present invention;
Fig. 2 is the photoconduction connection diagram of the first embodiment in imaging device of the present invention;
Fig. 3 is the optic grease coupling schematic diagram of the second embodiment in imaging device of the present invention;
Fig. 4 is that in imaging device of the present invention, probe unit responds schematic diagram to point source.
Detailed description of the invention
The exemplary embodiments embodying feature & benefits of the present invention will describe in detail in the following description.Be understood that the present invention can have various changes in different embodiments, it neither departs from the scope of the present invention, and explanation wherein and accompanying drawing are the use when explain in itself, and is not used to limit the present invention.
As depicted in figs. 1 and 2, imaging device of the present invention comprises two detecting modules, 1, two detecting modules 1 and all meets plate 2 by one and be connected to host computer data handling system 3.Detecting module 1 is fixed in a machinery (not shown) adjustably, comprises the continuous crystal 11, photoelectric conversion part 12 and the array read-out electronics system 13 that are connected successively.
Continuous crystal 11 4 sides and upper surface scribble light absorbent, and adopt polishing to lower surface, the γ photon conversion of 511keV is passage of scintillation light by continuous crystal 11.Crystal type can select LYSO, also can be BGO, LSO, LuAP, LFS, GSO, GYSO, NaI(Tl), CsI(Tl) and LaBr3 etc.; Crystal shape can select cuboid, also can be the geometries such as terrace with edge; Crystal surface treatment mode also can adopt polishing, extinction process, diffuse-reflectance process etc., and the model of fit that different surface treatment modes is selected is also different.
The passage of scintillation light that continuous crystal produces is converted to the signal of telecommunication by photoelectric conversion part 12, obtains the Two dimensional Distribution situation of passage of scintillation light intensity at continuous crystal lower surface.Photoelectric conversion part 12 can be square photomultiplier tube, standard circular photomultiplier tube, multichannel photomultiplier tube, location-sensitive photomultiplier tube, based on the photomultiplier tube of microchannel plate, and avalanche photodiode array etc.
Between continuous crystal 11, photoelectric conversion part 12, adopt optical transmission medium 14 to connect.This optical transmission medium 14 can be that photoconduction 141 as shown in Figure 2 connects, and also can be coupled by optic grease 142 as shown in Figure 3.The optional fiber optic materials of photoconduction 141, concrete selectable from glass, quartz, polystyrene, acrylic acid, polyvinyl-toluene or the liquid core photoconduction etc. remained in minor diameter teflon pipe.
Array read-out electronics system 13 comprises signal and amplifies molding, digitized and network transmission module, and the signal of telecommunication sent by photoelectric conversion part 12 carries out amplification molding and digitized, data to be dealt into meet plate 2 by network transmission module.
Meet plate 2 and judge whether the two γ photon signals that two detecting modules 1 send take place at the same instant, and then two signals are sent to host computer data handling system 3 in this way and resolve; Be two signals as denied not from same example, thus give up.
Host computer data handling system 3 or array read-out electronics system 13 comprise position fitting unit, according to the detected intensity distribution I (m of probe unit each in photoelectric conversion part, and solid angle distributed model n), matching draws the active position s (x of γ photon and continuous crystal, y, z).Fitting formula is:
Wherein, m, n are independent variable, and I is dependent variable, and x, y, z, A are the parameter wanting matching.
be (m, n) individual probe unit to point source position s(x, y, z) open solid angle;
W is the width of each probe unit;
H is the height of each probe unit;
X, y, z is the active position of γ photon and continuous crystal;
A is normalization factor.
In photoelectric conversion part 12 (m, n) individual probe unit detected intensity for normalization factor and probe unit to point source position open the product of solid angle.
Technical scheme of the present invention is disclosed as above by preferred embodiment.The change that those skilled in the art do when should recognize the scope and spirit of the present invention disclosed in the claim do not departed from appended by the present invention and retouching, within the protection domain all belonging to claim of the present invention.
Claims (5)
1. the two flatbed imaging device based on continuous crystal, it is characterized in that, comprise two detecting modules, meet plate and host computer data handling system, described detecting module comprises continuous crystal, photoelectric conversion part and array read-out electronics system, described photoelectric conversion part is adjacent to described continuous crystal, described array read-out electronics system is connected with described photoelectric conversion part, meet plate described in described two detecting modules all pass through and be connected to described host computer data handling system, the described plate that meets judges whether two γ photon signals of detecting module collection described in two take place at the same instant, then two signals are sent to described host computer data handling system in this way, described host computer data handling system or described array read-out electronics system comprise position fitting unit, described photoelectric conversion part comprises multiple probe units of array arrangement, described position fitting unit is according to the detected intensity distribution I (m of described each probe unit, n), matching draws the active position s (x of the γ photon that extraneous radioactive source is injected and described continuous crystal, y, z), wherein m and n is the Position Number of probe unit, described position fitting unit adopts solid angle model, (m in described photoelectric conversion part, n) individual probe unit is to point source position s (x, y, z) open solid angle and be specially:
Wherein,
be (m, n) individual probe unit to point source position s (x, y, z) open solid angle;
W is the width of each probe unit;
H is the height of each probe unit;
X, y, z is the active position of described γ photon and continuous crystal.
2., as claimed in claim 1 based on two flatbed imaging device of continuous crystal, it is characterized in that, described continuous crystal four sides and upper surface scribble light absorbent.
3., as claimed in claim 1 based on two flatbed imaging device of continuous crystal, it is characterized in that, described continuous crystal is connected by photoconduction or optic grease direct-coupling with described photoelectric conversion part.
4. as claimed in claim 1 based on two flatbed imaging device of continuous crystal, it is characterized in that, described array read-out electronics system is that multichannel reads.
5. as claimed in claim 1 based on two flatbed imaging device of continuous crystal, it is characterized in that, adopt the active position of solid angle model to γ photon and continuous crystal to carry out matching, and introduce normalization factor A in model of fit, and
.
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| CN106597518A (en) * | 2016-12-21 | 2017-04-26 | 中国科学院深圳先进技术研究院 | PET detector, PET imaging system and PET tester |
| CN109924995B (en) * | 2017-12-15 | 2023-06-27 | 深圳先进技术研究院 | Double-ended read-out detector unit and double-ended read-out detector |
| CN110477942B (en) * | 2019-08-20 | 2023-06-23 | 上海联影医疗科技股份有限公司 | PET detector and medical imaging equipment |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203668A (en) * | 1995-10-12 | 1998-12-30 | 阿达克实验室 | Resolution enhancement for dual head gamma camera |
| US6175116B1 (en) * | 1997-06-02 | 2001-01-16 | Picker International, Inc. | Hybrid collimation and coincidence imager for simultaneous positron and single photon imaging |
| CN102655813A (en) * | 2009-10-27 | 2012-09-05 | 华盛顿大学商业中心 | Optical-interface patterning for radiation detector crystals |
| CN103099637A (en) * | 2013-02-21 | 2013-05-15 | 清华大学 | Image reconstruction method for dual panel position-emission tomography (PET) detector |
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| US6946658B2 (en) * | 2002-07-05 | 2005-09-20 | The Washington University | Method and apparatus for increasing spatial resolution of a pet scanner |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203668A (en) * | 1995-10-12 | 1998-12-30 | 阿达克实验室 | Resolution enhancement for dual head gamma camera |
| US6175116B1 (en) * | 1997-06-02 | 2001-01-16 | Picker International, Inc. | Hybrid collimation and coincidence imager for simultaneous positron and single photon imaging |
| CN102655813A (en) * | 2009-10-27 | 2012-09-05 | 华盛顿大学商业中心 | Optical-interface patterning for radiation detector crystals |
| CN103099637A (en) * | 2013-02-21 | 2013-05-15 | 清华大学 | Image reconstruction method for dual panel position-emission tomography (PET) detector |
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