CN103766914A - Semi-bionic extraction method of dietary supplement - Google Patents
Semi-bionic extraction method of dietary supplement Download PDFInfo
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- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 20
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- 239000002994 raw material Substances 0.000 claims abstract description 38
- 238000001471 micro-filtration Methods 0.000 claims abstract description 34
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 34
- 238000001728 nano-filtration Methods 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 16
- 239000000047 product Substances 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 13
- 238000003809 water extraction Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 239000012530 fluid Substances 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 210000004027 cell Anatomy 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 230000003750 conditioning effect Effects 0.000 claims description 24
- 239000006228 supernatant Substances 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 19
- 244000005700 microbiome Species 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 238000000746 purification Methods 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 238000010009 beating Methods 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 6
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- 239000012535 impurity Substances 0.000 claims description 6
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- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims description 4
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 4
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims description 4
- 229940074393 chlorogenic acid Drugs 0.000 claims description 4
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims description 4
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 4
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims description 4
- 235000015203 fruit juice Nutrition 0.000 claims description 4
- 229940094952 green tea extract Drugs 0.000 claims description 4
- 235000020688 green tea extract Nutrition 0.000 claims description 4
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- 235000019698 starch Nutrition 0.000 claims description 4
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- 238000005406 washing Methods 0.000 claims description 4
- 210000005253 yeast cell Anatomy 0.000 claims description 4
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000002378 acidificating effect Effects 0.000 abstract 4
- 239000003513 alkali Substances 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 238000004537 pulping Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000021506 Ipomoea Nutrition 0.000 description 1
- 241000207783 Ipomoea Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- -1 flavone compound Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to a semi-bionic extraction method of a dietary supplement. The semi-bionic extraction method is characterized by comprising the following steps: forming an acidic water extraction production line 1 and an alkaline water extraction production line 2 by two sets of equipment with the same structure; adding a raw material A to an acidic pH regulator a, feeding into the acidic water extraction production line 1, pulping and filtering, carrying out cyclone desanding and microbubble cyclone elution and extraction to break nano-scale microbial cells, carrying out microfiltration, ultrafiltration and nanofiltration, drying in a vacuum scraper blade, and collecting to obtain finished-product dry powder a; and collecting and mixing a raw material B with filtrate obtained in the acidic water extraction process, adding an alkaline pH regulator b, feeding into the alkali water extraction production line 2, repeating the process till finished-product dry powder b is collected, and mixing a material D with the dry powder a and the dry powder b to obtain the dietary supplement obtained by using the semi-bionic extraction method.
Description
Technical field
The present invention relates to a kind of half bionic extraction method that field of fine chemical ， Te Do relates to dietary supplements.
Background technology
FDA Food and Drug Administration's (being called for short FDA) has announced " dietary supplements health and Education Act " (DSHEA), dietary supplements is made to following regulation: a kind of product (but not tobacco) that is intended to complementary diets, it may contain one or more following dietary ingredients, a kind of vitamin, a kind of mineral matter, a kind of draft (herbal medicine) or other plant, a seed amino acid, a kind ofly come the COF of complementary diets or a kind of concentrate, metabolin, composition, extract or the combination product etc. of above composition in order to increase every day total intake.
This more meets traditional Chinese medical science idea, and people take the prepared slices of Chinese crude drugs and form decoction, are that this is different from the pursuit of western medicine and medical practitioners to specific high-purity chemical thing by digesting and assimilating one group to the medicable active material of specific symptoms;
The applicable Bian of this wholesome dietary supplements digests and assimilates the extracting method of environment, i.e. half bionic extraction method with simulation human body;
In " progress of semi-bionic extraction in Chinese medicinal granule preparation " (Luo Lan sea Gap pharmacy 2,010 22.4), introduce semi-bionic extraction advantage;
Patent of invention " a kind of for blood stasis physique composition and preparation method and purposes " (201210349461.2) also discloses a kind of semi-bionic extraction with patent of invention " unit-combination type extracts technique and the device of Effective Component of Chinese Medicine " (200910094225.7).
Summary of the invention
Task of the present invention is under theory of traditional Chinese medical science is supported, half bionic extraction method of a kind of dietary supplements of more convenient and quicker is provided, it is characterized in that the beater with filter screen 1 identical with two nested structures, hydrocyclone 1, microbubble eddy flow is washed Off extraction equipment 1, Nanometer grade microorganism cell crushing machine 1, micro-filtration filter 1, ultra filtration filter 1, nanofiltration filter 1, vacuum scraper drying machine 1, with the beater 2 with filter screen, hydrocyclone 2, microbubble eddy flow is washed Off extraction equipment 2, Nanometer grade microorganism cell crushing machine 2, micro-filtration filter 2, ultra filtration filter 2, nanofiltration filter 2, vacuum scraper drying machine 2, sequentially form acid water extraction streamline 1 and alkaline water extraction streamline 2 by pipe link,
Raw material completes processing according to following program:
A. add by completing cleaning raw material A the water mixing A that contains acid PH conditioning agent a, must be mixed with the raw material A of acid PH conditioning agent a water;
B. will be mixed with the raw material A of acid PH conditioning agent a water, beater 1 making beating of sending into filter screen is filtered, and removes filter residue a1, receives to obtain filtered fluid b1;
C. filtered fluid b1 is sent into hydrocyclone 1 and separate, remove possibility impurity, receive to obtain supernatant c1;
D. supernatant c1 is sent into microbubble eddy flow and wash Off extraction equipment 1, add water purification dilution, disperse to wash Off, remove lower underflow d1, receive to such an extent that disperse to wash the supernatant e1 of Off;
E. the supernatant e1 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 1, further disperse homogeneously, receive and to obtain further broken clear liquid f1 of cell;
F. by further broken clear liquid f1 of cell, send into micro-filtration filter 1 and filter, remove micro-filtration trapped fluid g1, receive to obtain micro-filtration filtered solution h1;
G. by micro-filtration filtered solution h1, send into ultra filtration filter 1 and filter, remove ultrafiltration trapped fluid i1, receive to such an extent that ultrafiltration filters
Liquid j1;
H. by ultrafiltration filtered solution j1, send into nanofiltration filter 1 and filter, receive to obtain nanofiltration trapped fluid k1, filtration be inorganic salts and water;
I. by nanofiltration trapped fluid k1, send into vacuum scraper drying machine 1 dry, receive to obtain finished product dry powder a;
J. collect and mix filter residue a1 in the above-mentioned b flow process of B, lower underflow d1 in d flow process, in f flow process, micro-filtration is held back
Liquid g1, ultrafiltration trapped fluid i1 in g flow process, forms new raw material B; The new raw material B that completes mixing B is added to the water mixed C that contains alkaline PH conditioning agent b, must be mixed with the new raw material B of alkaline PH conditioning agent b water,
L. the new raw material B of alkaline PH conditioning agent b water will be mixed with; Beater 2 making beating of sending into filter screen are filtered, and remove filter residue a2, receive to obtain filtered fluid b2;
M. filtered fluid b2 is sent into hydrocyclone 2 and separate, remove possibility impurity, receive to obtain supernatant c2;
N. supernatant c2 is sent into microbubble eddy flow and wash Off extraction equipment 2, add water purification dilution, disperse to wash Off, remove lower underflow d2, receive to such an extent that disperse to wash the supernatant e2 of Off;
O. the supernatant e2 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 2, further disperse homogeneously, receive and to obtain further broken clear liquid f2 of cell;
P. by further broken clear liquid f2 of cell, send into micro-filtration filter 2 and filter, remove micro-filtration trapped fluid g2, receive to obtain micro-filtration filtered solution h2;
Q. by micro-filtration filtered solution h2, send into ultra filtration filter 2 and filter, remove ultrafiltration trapped fluid i2, receive to such an extent that ultrafiltration filters
Liquid j2;
S. by ultrafiltration filtered solution j2, send into nanofiltration filter 2 and filter, receive to obtain nanofiltration trapped fluid k2, filtration be inorganic salts and water;
T. by nanofiltration trapped fluid k2, send into vacuum scraper drying machine 2 dry, receive to obtain finished product dry powder b;
V. mix A receive finished product dry powder a with receive to such an extent that finished product dry powder b is the dietary supplements of the present invention's half bionic extraction.
Beneficial effect of the present invention is to simulate human body digestion process, fast and effeciently obtain target extract dietary supplements, pull an oar to imitate by beater and chew, wash Off extraction equipment and Nanometer grade microorganism cell crushing machine imitation peptic digest by microbubble eddy flow, imitate intestinal absorption by membrane filtration; Imitate the pH value of digestive environments by acid PH conditioning agent a and alkaline PH conditioning agent b.
Accompanying drawing explanation
Accompanying drawing 1 is process chart of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing 1, technique of the present invention is described further, but following embodiment is not to Yue Bouquet of the present invention.
Task of the present invention is under theory of traditional Chinese medical science is supported, half bionic extraction method of a kind of dietary supplements of more convenient and quicker is provided, it is characterized in that the beater with filter screen 1 of the fruit juice industry universal identical with two nested structures, the hydrocyclone 1 of starch industry universal, microbubble eddy flow is washed Off extraction equipment 1, No. 201110340615.5 patents of invention " a kind of microbubble eddy flow wash-out extraction equipment and technique " disclose this efficient Off equipment of washing that separates, Nanometer grade microorganism cell crushing machine 1, " research of yeast cells crushing technology " (145 phases were brewageed for by Yao Hong literary composition China) discloses Nanometer grade microorganism cell crushing machine structure and application, micro-filtration filter 1, adopt the ceramic membrane of 30nm, ultra filtration filter 1, what Bian used is that molecular cut off is 10000 film, nanofiltration filter 1, what Bian used is that molecular cut off is 200 film, the vacuum scraper drying machine 1 that pharmaceutical industry is general, the beater with filter screen 2 with fruit juice industry universal, the hydrocyclone 2 of starch industry universal, microbubble eddy flow is washed Off extraction equipment 2, No. 201110340615.5 patents of invention " a kind of microbubble eddy flow wash-out extraction equipment and technique " disclose this efficient Off equipment of washing that separates, Nanometer grade microorganism cell crushing machine 2, " research of yeast cells crushing technology " (145 phases were brewageed for by Yao Hong literary composition China) discloses Nanometer grade microorganism cell crushing machine structure and application, micro-filtration filter 2, adopt the ceramic membrane of 30nm, ultra filtration filter 2, what Bian used is that molecular cut off is 10000 film, nanofiltration filter 2, what Bian used is that molecular cut off is 200 film, the vacuum scraper drying machine that pharmaceutical industry is general sequentially forms acid water extraction streamline 1 and alkaline water extraction streamline 2 by pipe link,
Raw material completes processing according to following program:
A. add by completing cleaning raw material A the water mixing A that contains acid PH conditioning agent a, must be mixed with the raw material A of acid PH conditioning agent a water, add water be raw material A weight 3-6 doubly, acid PH conditioning agent a is a kind of in hydrochloric acid, acetic acid, citric acid, regulates pH value 2.0-5.0;
B. will be mixed with the raw material A of acid PH conditioning agent a water, beater 1 making beating of sending into filter screen is filtered, and removes filter residue a1, receives to obtain filtered fluid b1;
C. filtered fluid b1 is sent into hydrocyclone 1 and separate, remove possibility impurity, receive to obtain supernatant c1;
D. supernatant c1 is sent into microbubble eddy flow and wash Off extraction equipment 1, add water purification dilution, disperse to wash Off, remove lower underflow d1, receive to such an extent that disperse to wash the supernatant e1 of Off;
Add water purification be original raw material A weight 10-20 doubly;
E. the supernatant e1 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 1, further disperse homogeneously, receive and to obtain further broken clear liquid f1 of cell;
F. by further broken clear liquid f1 of cell, send into micro-filtration filter 1 and filter, remove micro-filtration trapped fluid g1, receive to obtain micro-filtration filtered solution h1;
G. by micro-filtration filtered solution h1, send into ultra filtration filter 1 and filter, remove ultrafiltration trapped fluid i1, receive to obtain ultrafiltration filtered solution j1;
H. by ultrafiltration filtered solution j1, send into nanofiltration filter 1 and filter, receive to obtain nanofiltration trapped fluid k1, filtration be inorganic salts and water;
I. by nanofiltration trapped fluid k1, send into vacuum scraper drying machine 1 dry, receive to obtain finished product dry powder a;
J. collect and mix filter residue a1 in the above-mentioned b flow process of B, lower underflow d1 in d flow process, in f flow process, micro-filtration is held back
Liquid g1, ultrafiltration trapped fluid i1 in g flow process, forms new raw material B; The new raw material B that completes mixing B is added to the water mixed C that contains alkaline PH conditioning agent b, must be mixed with the new raw material B of alkaline PH conditioning agent b water;
Add water be new raw material B weight 3-6 doubly, alkaline PH conditioning agent b is a kind of in sodium acid carbonate, NaOH, regulates pH value 7.5-9.0;
L. will be mixed with the new raw material B of alkaline PH conditioning agent b water, beater 2 making beating of sending into filter screen are filtered, and remove filter residue a2, receive to obtain filtered fluid b2;
M. filtered fluid b2 is sent into hydrocyclone 2 and separate, remove possibility impurity, receive to obtain supernatant c2;
N. supernatant c2 is sent into microbubble eddy flow and wash Off extraction equipment 2, add water purification dilution, disperse to wash Off, remove lower underflow d2, receive to such an extent that disperse to wash the supernatant e2 of Off;
Add water purification be original new raw material B weight 10-20 doubly;
O. the supernatant e2 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 2, further disperse homogeneously, receive and to obtain further broken clear liquid f2 of cell;
P. by further broken clear liquid f2 of cell, send into micro-filtration filter 2 and filter, remove micro-filtration trapped fluid g2, receive to obtain micro-filtration filtered solution h2;
Q. by micro-filtration filtered solution h2, send into ultra filtration filter 2 and filter, remove ultrafiltration trapped fluid i2, receive to such an extent that ultrafiltration filters
Liquid j2;
S. by ultrafiltration filtered solution j2, send into nanofiltration filter 2 and filter, receive to obtain nanofiltration trapped fluid k2, filtration be inorganic salts and water;
T. by nanofiltration trapped fluid k2, send into vacuum scraper drying machine 2 dry, receive to obtain finished product dry powder b;
V. mix D receive finished product dry powder a with receive to such an extent that finished product dry powder b is the dietary supplements of the present invention's half bionic extraction.
embodiment 1
Research finds that sweet potato leaves is containing chlorogenic acid 4.45%, flavone compound 9.46%;
Patent of invention " a kind of Folium Ipomoea extract, its preparation method and application " (201110158438.9), patent of invention " a kind of from sweet potato leaves the industrial technology (200910147813.2) of rapid extraction high-purity chlorogenic acid be all doctor trained in Western medicine is theoretical support under, produce as high-purity medicament.
Utilize equipment and technology of the present invention, using the sweet potato leaves that completes cleaning as raw material A, under theory of traditional Chinese medical science is supported, utilize half bionic extraction technology to extract from sweet potato leaves and be rich in chlorogenic acid and chromocor extract, as wholesome dietary supplements or feed addictive.
embodiment 2
Green tea extraction, because of its good health care, has been general dietary supplements;
Patent of invention " has green-tea extract of hypoglycemic activity and preparation method thereof " the traditional aqueous extraction-alcohol precipitation technology of (200810154827.2) Bian, patent of invention " production technology of green-tea extract " (200910154392.6) is traditional alcohol extracting macroporous resin adsorption technique for Bian.
Utilize equipment and technology of the present invention, using the tealeaves that completes cleaning as raw material A, under theory of traditional Chinese medical science is supported, utilize half bionic extraction technology from tealeaves, to extract green-tea extract, as wholesome dietary supplements.
Claims (3)
1. half bionic extraction method of a dietary supplements, it is characterized in that the beater with filter screen 1 of the fruit juice industry universal identical with two nested structures, the hydrocyclone 1 of starch industry universal, microbubble eddy flow is washed Off extraction equipment 1, No. 201110340615.5 patents of invention " a kind of microbubble eddy flow wash-out extraction equipment and technique " disclose this efficient Off equipment of washing that separates, Nanometer grade microorganism cell crushing machine 1, " research of yeast cells crushing technology " (145 phases were brewageed for by Yao Hong literary composition China) discloses Nanometer grade microorganism cell crushing machine structure and application, micro-filtration filter 1, adopt the ceramic membrane of 30nm, ultra filtration filter 1, what Bian used is that molecular cut off is 10000 film, nanofiltration filter 1, what Bian used is that molecular cut off is 200 film, the vacuum scraper drying machine 1 that pharmaceutical industry is general, the beater with filter screen 2 with fruit juice industry universal, the hydrocyclone 2 of starch industry universal, microbubble eddy flow is washed Off extraction equipment 2, No. 201110340615.5 patents of invention " a kind of microbubble eddy flow wash-out extraction equipment and technique " disclose this efficient Off equipment of washing that separates, Nanometer grade microorganism cell crushing machine 2, " research of yeast cells crushing technology " (145 phases were brewageed for by Yao Hong literary composition China) discloses Nanometer grade microorganism cell crushing machine structure and application, micro-filtration filter 2, adopt the ceramic membrane of 30nm, ultra filtration filter 2, what Bian used is that molecular cut off is 10000 film, nanofiltration filter 2, what Bian used is that molecular cut off is 200 film, the vacuum scraper drying machine that pharmaceutical industry is general, sequentially form acid water extraction streamline 1 and alkaline water extraction streamline 2 by pipe link,
Raw material completes processing according to following program:
A. add by completing cleaning raw material A the water mixing A that contains acid PH conditioning agent a, must be mixed with the raw material A of acid PH conditioning agent a water; Add water be raw material A weight 3-6 doubly, acid PH conditioning agent a is a kind of in hydrochloric acid, acetic acid, citric acid, regulates pH value 2.0-5.0;
B. the raw material A of acid PH conditioning agent a water will be mixed with; Beater 1 making beating of sending into filter screen is filtered, and removes filter residue a1, receives to obtain filtered fluid b1;
C. filtered fluid b1 is sent into hydrocyclone 1 and separate, remove possibility impurity, receive to obtain supernatant c1;
D. supernatant c1 is sent into microbubble eddy flow and wash Off extraction equipment 1, add water purification dilution, disperse to wash Off, remove lower underflow d1, receive to such an extent that disperse to wash the supernatant e1 of Off;
Add water purification be original raw material A weight 10-20 doubly;
E. the supernatant e1 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 1, further disperse homogeneously, receive and to obtain further broken clear liquid f1 of cell;
F. by further broken clear liquid f1 of cell, send into micro-filtration filter 1 and filter, remove micro-filtration trapped fluid g1, receive to obtain micro-filtration filtered solution h1;
G. by micro-filtration filtered solution h1, send into ultra filtration filter 1 and filter, remove ultrafiltration trapped fluid i1, receive to obtain ultrafiltration filtered solution j1;
H. by ultrafiltration filtered solution j1, send into nanofiltration filter 1 and filter, receive to obtain nanofiltration trapped fluid k1, filtration be inorganic salts and water;
I. by nanofiltration trapped fluid k1, send into vacuum scraper drying machine 1 dry, receive to obtain finished product dry powder a;
J. collect and mix filter residue a1 in the above-mentioned b flow process of B, lower underflow d1 in d flow process, in f flow process, micro-filtration is held back
Liquid g1, ultrafiltration trapped fluid i1 in g flow process, forms new raw material B; Add by completing mixing B new raw material B the water mixed C that contains alkaline PH conditioning agent b, must be mixed with the new raw material B of alkaline PH conditioning agent b water;
Add water be new raw material B weight 3-6 doubly, alkaline PH conditioning agent b is a kind of in sodium acid carbonate, NaOH, regulates pH value 7.5-9.0;
L. will be mixed with the new raw material B of alkaline PH conditioning agent b water, beater 2 making beating of sending into filter screen are filtered, and remove filter residue a2, receive to obtain filtered fluid b2;
M. filtered fluid b2 is sent into hydrocyclone 2 and separate, remove possibility impurity, receive to obtain supernatant c2;
N. supernatant c2 is sent into microbubble eddy flow and wash Off extraction equipment 2, add water purification dilution, disperse to wash Off, remove lower underflow d2, receive to such an extent that disperse to wash the supernatant e2 of Off;
Add water purification be original new raw material B weight 10-20 doubly;
O. the supernatant e2 that disperses to wash Off is sent into and in Nanometer grade microorganism cell crushing machine 2, further disperse homogeneously, receive and to obtain further broken clear liquid f2 of cell;
P. by further broken clear liquid f2 of cell, send into micro-filtration filter 2 and filter, remove micro-filtration trapped fluid g2, receive to obtain micro-filtration filtered solution h2;
Q. by micro-filtration filtered solution h2, send into ultra filtration filter 2 and filter, remove ultrafiltration trapped fluid i2, receive to such an extent that ultrafiltration filters
Liquid j2;
S. by ultrafiltration filtered solution j2, send into nanofiltration filter 2 and filter, receive to obtain nanofiltration trapped fluid k2, filtration be inorganic salts and water;
T. by nanofiltration trapped fluid k2, send into vacuum scraper drying machine 2 dry, receive to obtain finished product dry powder b;
V. mix D receive finished product dry powder a with receive to such an extent that finished product dry powder b is the dietary supplements of the present invention's half bionic extraction.
2. according to right 1, make raw material A by sweet potato leaves, therefrom extract and be rich in chlorogenic acid and chromocor extract, as wholesome dietary supplements.
3. according to right 1, make raw material A with tealeaves, therefrom extract green-tea extract, as wholesome dietary supplements.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861636A (en) * | 2005-05-10 | 2006-11-15 | 上海市农业科学院 | Process for half bionic extracting preparing hedgehogt fungus crude polysaccharose |
| US7167090B1 (en) * | 2004-09-17 | 2007-01-23 | Massachusetts Institute Of Technology | Far-field RF power extraction circuits and systems |
| CN101731600A (en) * | 2008-11-20 | 2010-06-16 | 索绪斌 | Formulation of digestion-aid plant functional beverage and preparation method thereof |
| CN102512458A (en) * | 2011-12-23 | 2012-06-27 | 正源堂（天津）生物科技有限公司 | Semi-bionic extraction method for active components of Cordyceps militaris |
| CN103083937A (en) * | 2011-10-31 | 2013-05-08 | 王钜 | Micro-bubble cyclone elution extraction device and technology |
-
2014
- 2014-01-24 CN CN201410034455.5A patent/CN103766914B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7167090B1 (en) * | 2004-09-17 | 2007-01-23 | Massachusetts Institute Of Technology | Far-field RF power extraction circuits and systems |
| CN1861636A (en) * | 2005-05-10 | 2006-11-15 | 上海市农业科学院 | Process for half bionic extracting preparing hedgehogt fungus crude polysaccharose |
| CN101731600A (en) * | 2008-11-20 | 2010-06-16 | 索绪斌 | Formulation of digestion-aid plant functional beverage and preparation method thereof |
| CN103083937A (en) * | 2011-10-31 | 2013-05-08 | 王钜 | Micro-bubble cyclone elution extraction device and technology |
| CN102512458A (en) * | 2011-12-23 | 2012-06-27 | 正源堂（天津）生物科技有限公司 | Semi-bionic extraction method for active components of Cordyceps militaris |
Non-Patent Citations (3)
| Title |
|---|
| 姚洪文，等: "酵母细胞破碎技术的研究", 《中国酿造》 * |
| 李立，等: "半仿生法提取黄芩苷的研究", 《中成药》 * |
| 陈晓娟，等: "酶法和半仿生法提取杜仲叶中绿原酸和黄酮", 《精细化工》 * |
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Effective date of registration: 20230925 Address after: Room A-35, 4th Floor, Building 14, Innovation Park, No. 3 Keji East Road, Jianping Village, Shangjie Town, Minhou County, Fuzhou City, Fujian Province, 350000 Patentee after: Huanyu Tongzhen Tea Biotechnology (Fuzhou) Co.,Ltd. Address before: The white horse road Tongde road Taijiang District of Fuzhou City, Fujian province 350009 No. 53 bin de Park Building No. 3 Room 305 Patentee before: Hou Mengbin |