CN103357117A - Elastic active particle and implant method thereof - Google Patents
Elastic active particle and implant method thereof Download PDFInfo
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- CN103357117A CN103357117A CN2012101011841A CN201210101184A CN103357117A CN 103357117 A CN103357117 A CN 103357117A CN 2012101011841 A CN2012101011841 A CN 2012101011841A CN 201210101184 A CN201210101184 A CN 201210101184A CN 103357117 A CN103357117 A CN 103357117A
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- elasticity
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- radioactive particle
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Abstract
The invention discloses an elastic active particle and an implant method thereof. The elastic active particle includes an active source. The active source includes a spiral spring made of an elastic medical material and radioisotopes which are capable of treating tumors and attached on the elastic spiral spring. Because the active source of the spiral spring structure has excellent elasticity and is capable of adapting to crooked pipes so that the active particle has excellent flexibility and can be released through complex crooked pipes. Therefore, requirements of tumor conformal implant of the active particle can be met.
Description
Technical field
The present invention relates to a kind of radioactive particle for the treatment of tumor, especially for the treatment tumor can carry out diastrophic elasticity embedded type radioactive particle.
Background technology
By implanting
125The I radioactive particle is treated tumor, has become one of a kind of effective ways for the treatment of of solid tumors at present.Prior art
125The typical structure of I radioactive particle is as follows: will
125I is adsorbed on the silver metal rod of diameter 0.5mm, length 3.5mm, has then adsorbed this
125It is that 0.8mm, length are in the titanium light-wall pipe of 4.5mm that the silver-colored rod of I is encapsulated in external diameter.Because prior art is this
125The I radioactive particle is the cylinder of rigidity, thereby can only put by staight needle type implantation device, needs repeatedly tumor section to be punctured, and could form effective increased radioactivity and covering.There is following shortcoming in this prior art:
1) a radion implant needle can only relate to a direction, a position.But in tumor therapeutic procedure, often need radion is distributed in multi-direction implantation a plurality of positions of tumor, so just needing to implement multichannel puncture particle implants, namely need a plurality of percutaneous puncture points and a plurality of puncture needle tubing and a plurality of puncture nook closing member, the apparatus that uses is more, cloth source and inconvenient operation, the damage that the patient is caused is large, and medical expense is high.
2) tumor, intracranial tumor behind the rib that stops if any skeleton for the tumor of privileged sites or behind the breastbone, and the tumor at the many position of peripheral vessels and intestinal tube such as pancreas tumor etc., the radion implant needle of prior art is difficult to reach desired location, thereby can't implement and operate.
3) can not select and change direction and the position of implantation, so be difficult to be fit to shape of tumor, can't realize that suitable shape is implanted.
For this reason, in the patent applications such as CN 101829393A, disclose a kind of single channel multidirectional tumor conformal shape radioactive particle implantation device, by being arranged on the looper of head, can realize by single channel the implantation of multi-direction multiple location, reduce the use of apparatus, reduced patient's damage.But this new particle implanting device head is looper, i.e. arc pin, this rigid cylindrical build of prior art
125The I radioactive particle is can not be by the bending section of looper, thereby need to the radioactive particle of prior art be improved, and provides a kind of new
125The I radioactive particle.
Summary of the invention
The elasticity radioactive particle, described elasticity radioactive particle contains radioactive source 2.Described radioactive source 2 contains the helical spring 21 that the radiosiotope 22 that can treat tumor and elasticity medical material are made, and radiosiotope 22 is attached on the elastic helix spring 21.
Further, described elasticity medical material is can deform under external force, behind the external force removal, can return to again the medical material of original shape, be selected from: the medical materials such as Ti-Ni marmem, titanium zirconium-niobium alloy, titanium-based amorphous attitude alloy, Zirconium based amorphous alloy, medical stainless steel, medical precious metal material.
Described elastic helix spring 21 is sealing screw springs.
Two ends of described elastic helix spring 21 are provided with the guide head 211 of rounding off.
In addition, described elasticity radioactive particle also contains elastic housing 1, described elastic housing 1 adopts elasticity medical metal material or elasticity medical macromolecular materials to make, described elastic housing 1 contains body 11 and sealing 10, described radioactive source 2 places in the body 11, seal 10 sealed tube bodies, radioactive source 2 is sealed in the elastic housing 1.
Further, the body 11 of described elastic housing 1 is the light-wall pipe that adopts elasticity medical metal material or elasticity medical macromolecular materials to make.
The body 11 of described elastic housing 1 is to have elastic thin-wall corrugated tube.
Described radiosiotope 22 is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169.
The present invention also provides the method for implantation of elasticity radioactive particle, and described method for implantation is to be that the particle implantation device of arc looper discharges with the present invention's elasticity radioactive particle by head.
The invention discloses a kind of elasticity radioactive particle, described elasticity radioactive particle contains radioactive source 2, described radioactive source 2 contains the helical spring 21 that the radiosiotope 22 that can treat tumor and elasticity medical material are made, and radiosiotope 22 is attached on the elastic helix spring 21.Because helical spring structure radioactive source 2 has good elasticity, can adapt to crooked pipeline, so this radioactive particle has good compliance, can discharge by the crooked pipeline of complexity, satisfy the requirement that tumor conformal shape radioactive particle is implanted.
Description of drawings
Fig. 1 is the structural representation of the present invention's solid matter spiral spring type elasticity radioactive particle.
Fig. 2 is the structural representation with the present invention's of thin-walled tubular outer casing elasticity radioactive particle.
Fig. 3 is the structural representation with the present invention's of bellows shell elasticity radioactive particle.
Fig. 4 is that the present invention's elasticity radioactive particle is by the fundamental diagram of the curved bend tune of particle implantation device.
Among the above-mentioned figure: 1 is housing, and 2 is radioactive source, and 4 are the present invention's elasticity radioactive particle, and 5 is the crooked interior pin of implantation device, and 6 is the outer pin of implantation device, and 7 is the inner core push rod of implantation device; 10 are sealing, and 11 is body, and 21 is helical spring, and 22 is radiosiotope, and 111 is the bellows body, and 112 is thin-walled cast body, and 211 is the guide head on the helical spring.
The specific embodiment
Embodiment 1: the present invention's solid matter spiral spring type elasticity radioactive particle
With reference to figure 1, in the present embodiment, the present invention's solid matter spiral spring type elasticity radioactive particle is disclosed, described elasticity radioactive particle contains radioactive source 2, described radioactive source 2 contains the helical spring 21 that the radiosiotope 22 that can treat tumor and elasticity medical material are made, and radiosiotope 22 is attached on the elastic helix spring 21.
Further, described elastic helix spring 21 is sealing screw springs.Be provided with the guide head 211 of rounding off in two ends of described elastic helix spring 21.
Described elasticity medical material is can deform under external force, behind the external force removal, can return to again the medical material of original shape, be selected from: the medical materials such as Ti-Ni marmem, titanium zirconium-niobium alloy, titanium-based amorphous attitude alloy, Zirconium based amorphous alloy, medical stainless steel, medical precious metal material.
Described radiosiotope 22 is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169 etc. can treat the radiosiotope of tumor.
Because the helical spring structure radioactive source 2 of the present invention's solid matter spiral spring type elasticity radioactive particle has good elasticity, can adapt to crooked pipeline, so this radioactive particle has good compliance, can discharge by the crooked pipeline of complexity, satisfy the requirement that tumor conformal shape radioactive particle is implanted.
With reference to figure 4, with the particle with the arc looper, insert the tumor locus that needs to implant radioactive particle, to be with first pin 5 pin 6 interior releases outside linear type in the arc, under the effect of body temperature, bent by pin 5 in the arc of Ti-Ni marmem manufacturing, arrive predetermined particle implant site.Then, promote the inner core push rod 7 of particle implantation device, the elasticity radioactive particle 4 that is preset at the present invention in the pin 5 in the arc is released forward; Under the effect of the thrust of inner core push rod 7, because the present invention's elasticity radioactive particle 4 motion forward is subject to the constraint of the tube wall of pin 5 in the arc, strain occurs in the present invention's elasticity radioactive particle 4, by the crooked segmental arc of pin 5 in the arc, discharges smoothly.After the present invention's elasticity radioactive particle 4 arrives the front end of pin 5 in the arc, keep the inner core push rod 7 of implantation device motionless, discharge in the needle tubing of the pin 5 in the arc of drawing back, the present invention's elasticity radioactive particle 4 pin 5 in the arc of implantation device, be implanted in and subscribe the position.So repeatedly, can implant at predetermined tumor locus other particle according to radioactive particle therapeutic scheme in advance, realize the requirement that tumor conformal shape radioactive particle is implanted.
Embodiment 2: with the present invention's of thin-walled tubular outer casing elasticity radioactive particle
With reference to figure 2, the present embodiment is substantially the same manner as Example 1, and its difference is: the radioactive source 2 of the present invention's elasticity radioactive particle is coated fully by housing 1.Described elastic housing 1 adopts elasticity medical metal material or elasticity medical macromolecular materials to make, and described elastic housing 1 contains body 11 and sealing 10, and described radioactive source 2 places in the body 11, seals 10 sealed tube bodies, and radioactive source 2 is sealed in the elastic housing 1.
The body 11 of the elastic housing 1 of the present embodiment is the light-wall pipe that adopts the elasticity medical macromolecular materials to make, and the elasticity medical macromolecular materials are selected from: radiation-resistant medical silica-gel, radiation-resistant medical polyurethane etc. can radiation-resistant medical macromolecular materials.Radiation-resistant medical silica-gel or radiation-resistant medical polyurethane are coated in the outside of the helical spring structure radioactive source 2 with solid matter spiral spring type elasticity radioactive particle, formed elastic clad, namely the tube body at helical spring structure has formed elasticity medical macromolecular materials manufacturing elasticity body 11; Two ends at helical spring structure have formed the sealing 10 that coats helical spring guide head 211; Body 11 and sealing 10 form elastic housing 1, and described elastic housing 1 coats radioactive source 2 fully.
Embodiment 3: with the present invention's of bellows shell elasticity radioactive particle
With reference to figure 3, the present embodiment is substantially the same manner as Example 1, and its difference is: the radioactive source 2 of the present invention's elasticity radioactive particle is coated fully by the elastic shell 1 of bellows.The body 11 of described elastic housing 1 is to have elastic thin-wall corrugated tube, adopt the manufacturing of elasticity medical metal material, the sealing 10 of described elastic housing 1 is the solder joint that laser weld forms, and described radioactive source 2 places in the body 11, seal 10 sealed tube bodies, radioactive source 2 is sealed in the elastic housing 1.
The body 11 of the elastic housing 1 of the present embodiment is the thin-wall corrugated tube that adopts the elasticity medical metal material to make, and the elasticity medical metal material is selected from: the medical metal materials such as Ti-Ni marmem, titanium zirconium-niobium alloy, titanium-based amorphous attitude alloy, Zirconium based amorphous alloy, medical stainless steel, medical precious metal material.
Should be noted that open structure with illustrating can replace with the identical structure of other effect herein, the embodiment that simultaneously the present invention introduces realizes unique structure of the present invention.Although preferential embodiment of the present invention is introduced in this article and is illustrated; but those skilled in the art all know know these embodiment only be illustrate and oneself; those skilled in the art can make countless variations, improvement and replacement; and can not break away from the present invention; therefore, should define protection scope of the present invention according to what the spirit and scope of appending claims of the present invention were come.
Claims (9)
1. elasticity radioactive particle, it is characterized in that: described elasticity radioactive particle contains radioactive source (2), described radioactive source (2) contains the helical spring (21) that the radiosiotope (22) that can treat tumor and elasticity medical material are made, and radiosiotope (22) is attached on the elastic helix spring (21).
2. described elasticity radioactive particle according to claim 1, it is characterized in that: described elasticity medical material is can deform under external force, behind the external force removal, can return to again the medical material of original shape, be selected from: Ti-Ni marmem, titanium zirconium-niobium alloy, titanium-based amorphous attitude alloy, Zirconium based amorphous alloy, medical stainless steel, medical precious metal material.
3. described elasticity radioactive particle according to claim 1, it is characterized in that: described elastic helix spring (21) is the sealing screw spring.
4. described elasticity radioactive particle according to claim 1, it is characterized in that: two ends of described elastic helix spring (21) are provided with the guide head (211) of rounding off.
5. described elasticity radioactive particle according to claim 1, it is characterized in that: described elasticity radioactive particle contains elastic housing (1), described elastic housing (1) adopts elasticity medical metal material or elasticity medical macromolecular materials to make, and described elastic housing (1) contains body (11) and sealing (10); Described radioactive source (2) places in the body (11), sealing (10) sealed tube body, and radioactive source (2) is sealed in the elastic housing (1).
6. described elasticity radioactive particle according to claim 5, it is characterized in that: the body (11) of described elastic housing (1) is the light-wall pipe that adopts elasticity medical metal material or elasticity medical macromolecular materials to make.
7. described elasticity radioactive particle according to claim 6, it is characterized in that: the body (11) of described elastic housing (1) is to have elastic thin-wall corrugated tube.
8. described elasticity radioactive particle according to claim 1, it is characterized in that: described radiosiotope (22) is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169.
9. the method for implantation of elasticity radioactive particle is characterized in that: described elasticity radioactive particle is that the particle implantation device of arc looper discharges by head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101011841A CN103357117A (en) | 2012-04-06 | 2012-04-06 | Elastic active particle and implant method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101011841A CN103357117A (en) | 2012-04-06 | 2012-04-06 | Elastic active particle and implant method thereof |
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| CN103357117A true CN103357117A (en) | 2013-10-23 |
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| CN2012101011841A Pending CN103357117A (en) | 2012-04-06 | 2012-04-06 | Elastic active particle and implant method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113995950A (en) * | 2021-12-06 | 2022-02-01 | 新疆医科大学第三附属医院 | Iodine particle stomach tube for radiotherapy of esophageal tumor |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863284A (en) * | 1995-11-13 | 1999-01-26 | Localmed, Inc. | Devices and methods for radiation treatment of an internal body organ |
| US6066083A (en) * | 1998-11-27 | 2000-05-23 | Syntheon Llc | Implantable brachytherapy device having at least partial deactivation capability |
| US6210316B1 (en) * | 1998-08-12 | 2001-04-03 | Syntheon, Llc | Radioactive therapeutic seeds and methods of making the same |
| CN1360511A (en) * | 1999-07-14 | 2002-07-24 | 诺沃斯特公司 | Radioactive source train |
| US7232408B1 (en) * | 1999-06-18 | 2007-06-19 | Aea Technology Qsa Gmbh | Radiation source for endovascular radiation treatment |
| CN202892669U (en) * | 2012-04-06 | 2013-04-24 | 周红 | Elastic radioactive particle |
-
2012
- 2012-04-06 CN CN2012101011841A patent/CN103357117A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863284A (en) * | 1995-11-13 | 1999-01-26 | Localmed, Inc. | Devices and methods for radiation treatment of an internal body organ |
| US6210316B1 (en) * | 1998-08-12 | 2001-04-03 | Syntheon, Llc | Radioactive therapeutic seeds and methods of making the same |
| US6066083A (en) * | 1998-11-27 | 2000-05-23 | Syntheon Llc | Implantable brachytherapy device having at least partial deactivation capability |
| US7232408B1 (en) * | 1999-06-18 | 2007-06-19 | Aea Technology Qsa Gmbh | Radiation source for endovascular radiation treatment |
| CN1360511A (en) * | 1999-07-14 | 2002-07-24 | 诺沃斯特公司 | Radioactive source train |
| CN202892669U (en) * | 2012-04-06 | 2013-04-24 | 周红 | Elastic radioactive particle |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113995950A (en) * | 2021-12-06 | 2022-02-01 | 新疆医科大学第三附属医院 | Iodine particle stomach tube for radiotherapy of esophageal tumor |
| CN113995950B (en) * | 2021-12-06 | 2023-10-24 | 新疆医科大学第三附属医院 | Iodine particle stomach tube for radiotherapy of esophageal tumor |
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Application publication date: 20131023 |
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